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Dennis E. Discher, Ph.D. - Publications

Affiliations: 
Chemical & Biomolecular Engineering University of Pennsylvania, Philadelphia, PA, United States 
Area:
cell biophysics and polymer engineering
Website:
http://www.seas.upenn.edu/~discher/index.html

258 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Pfeifer CR, Vashisth M, Xia Y, Discher DE. Nuclear failure, DNA damage, and cell cycle disruption after migration through small pores: a brief review. Essays in Biochemistry. PMID 31366473 DOI: 10.1042/EBC20190007  0.32
2019 Pfeifer CR, Discher DE. Pulling the Roof Down on Anchored Nuclei. Developmental Cell. 50: 130-131. PMID 31336096 DOI: 10.1016/j.devcel.2019.07.003  0.32
2019 Xia Y, Pfeifer CR, Zhu K, Irianto J, Liu D, Pannell K, Chen EJ, Dooling LJ, Tobin MP, Wang M, Ivanovska IL, Smith LR, Greenberg RA, Discher DE. Rescue of DNA damage after constricted migration reveals a mechano-regulated threshold for cell cycle. The Journal of Cell Biology. PMID 31239284 DOI: 10.1083/jcb.201811100  0.76
2019 Smith LR, Irianto J, Xia Y, Pfeifer CR, Discher DE. Constricted migration modulates stem cell differentiation. Molecular Biology of the Cell. mbcE19020090. PMID 31188712 DOI: 10.1091/mbc.E19-02-0090  0.76
2019 Cho S, Vashisth M, Abbas A, Majkut S, Vogel K, Xia Y, Ivanovska IL, Irianto J, Tewari M, Zhu K, Tichy ED, Mourkioti F, Tang HY, Greenberg RA, Prosser BL, ... Discher DE, et al. Mechanosensing by the Lamina Protects against Nuclear Rupture, DNA Damage, and Cell-Cycle Arrest. Developmental Cell. PMID 31105008 DOI: 10.1016/j.devcel.2019.04.020  0.76
2018 Engler AJ, Discher DE. Rationally engineered advances in cancer research. Apl Bioengineering. 2: 031601. PMID 31069310 DOI: 10.1063/1.5056176  1
2018 Xia Y, Cho S, Vashisth M, Ivanovska IL, Dingal PCDP, Discher DE. Manipulating the mechanics of extracellular matrix to study effects on the nucleus and its structure. Methods (San Diego, Calif.). PMID 30593865 DOI: 10.1016/j.ymeth.2018.12.009  0.76
2018 Novikova EA, Raab M, Discher DE, Storm C. Erratum: Persistence-Driven Durotaxis: Generic, Directed Motility in Rigidity Gradients [Phys. Rev. Lett. 118, 078103 (2017)]. Physical Review Letters. 121: 159901. PMID 30362797 DOI: 10.1103/PhysRevLett.121.159901  0.92
2018 Xia Y, Ivanovska IL, Zhu K, Smith L, Irianto J, Pfeifer CR, Alvey CM, Ji J, Liu D, Cho S, Bennett RR, Liu AJ, Greenberg RA, Discher DE. Nuclear rupture at sites of high curvature compromises retention of DNA repair factors. The Journal of Cell Biology. PMID 30171044 DOI: 10.1083/jcb.201711161  0.76
2018 Chakraborty K, Vijayan K, Brown AEX, Discher DE, Loverde SM. Glassy worm-like micelles in solvent and shear mediated shape transitions. Soft Matter. PMID 29744515 DOI: 10.1039/c8sm00080h  0.96
2018 Pfeifer CR, Xia Y, Zhu K, Liu D, Irianto J, García VMM, Millán LMS, Niese B, Harding S, Deviri D, Greenberg RA, Discher DE. Constricted migration increases DNA damage and independently represses cell cycle. Molecular Biology of the Cell. mbcE18020079. PMID 29742017 DOI: 10.1091/mbc.E18-02-0079  0.76
2018 Cho S, Abbas A, Irianto J, Ivanovska I, Xia Y, Tewari M, Discher DE. Progerin phosphorylation in interphase is lower and less mechanosensitive than lamin-A,C in iPS-derived mesenchymal stem cells. Nucleus (Austin, Tex.). 1-32. PMID 29619860 DOI: 10.1080/19491034.2018.1460185  0.76
2018 Nair P, Alvey C, Jin X, Irianto J, Ivanovska I, Discher DE. Filomicelles deliver a chemo-differentiation combination of Paclitaxel and Retinoic Acid that durably represses carcinomas in liver to prolong survival. Bioconjugate Chemistry. PMID 29451777 DOI: 10.1021/acs.bioconjchem.7b00816  0.76
2017 Pfeifer CR, Alvey CM, Irianto J, Discher DE. Genome variation across cancers scales with tissue stiffness - an invasion-mutation mechanism and implications for immune cell infiltration. Current Opinion in Systems Biology. 2: 103-114. PMID 29082336 DOI: 10.1016/j.coisb.2017.04.005  0.76
2017 Buxboim A, Irianto J, Swift J, Athirasala A, Shin JW, Rehfeldt F, Discher DE. Coordinated increase of nuclear tension and lamin-A with matrix stiffness out-competes Lamin-B Receptor which favors soft tissue phenotypes. Molecular Biology of the Cell. PMID 28931598 DOI: 10.1091/mbc.E17-06-0393  0.76
2017 Deviri D, Discher DE, Safran SA. Rupture Dynamics and Chromatin Herniation in Deformed Nuclei. Biophysical Journal. 113: 1060-1071. PMID 28877489 DOI: 10.1016/j.bpj.2017.07.014  0.36
2017 Harding SM, Benci JL, Irianto J, Discher DE, Minn AJ, Greenberg RA. Mitotic progression following DNA damage enables pattern recognition within micronuclei. Nature. PMID 28759889 DOI: 10.1038/nature23470  0.76
2017 Alvey CM, Spinler KR, Irianto J, Pfeifer CR, Hayes B, Xia Y, Cho S, Dingal PCPD, Hsu J, Smith L, Tewari M, Discher DE. SIRPA-Inhibited, Marrow-Derived Macrophages Engorge, Accumulate, and Differentiate in Antibody-Targeted Regression of Solid Tumors. Current Biology : Cb. PMID 28669759 DOI: 10.1016/j.cub.2017.06.005  0.76
2017 Bennett RR, Pfeifer CR, Irianto J, Xia Y, Discher DE, Liu AJ. Elastic-Fluid Model for DNA Damage and Mutation from Nuclear Fluid Segregation Due to Cell Migration. Biophysical Journal. 112: 2271-2279. PMID 28591600 DOI: 10.1016/j.bpj.2017.04.037  0.76
2017 Ivanovska IL, Swift J, Spinler K, Dingal D, Cho S, Discher DE. Cross-linked matrix rigidity and soluble retinoids synergize in nuclear lamina regulation of stem cell differentiation. Molecular Biology of the Cell. PMID 28566555 DOI: 10.1091/mbc.E17-01-0010  0.76
2017 Mahmud A, Harada T, Rajagopal K, Christian DA, Nair P, Murphy R, Discher DE. Spray stability of self-assembled filaments for delivery. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 28549950 DOI: 10.1016/j.jconrel.2017.05.026  0.76
2017 Irianto J, Xia Y, Pfeifer CR, Greenberg RA, Discher DE. As a Nucleus Enters a Small Pore, Chromatin Stretches and Maintains Integrity, Even with DNA Breaks. Biophysical Journal. 112: 446-449. PMID 28341535 DOI: 10.1016/j.bpj.2016.09.047  0.76
2017 Novikova EA, Raab M, Discher DE, Storm C. Persistence-Driven Durotaxis: Generic, Directed Motility in Rigidity Gradients. Physical Review Letters. 118: 078103. PMID 28256894 DOI: 10.1103/PhysRevLett.118.078103  0.92
2017 Cho S, Irianto J, Discher DE. Mechanosensing by the nucleus: From pathways to scaling relationships. The Journal of Cell Biology. PMID 28043971 DOI: 10.1083/jcb.201610042  0.76
2016 Sosale NG, Ivanovska II, Tsai RK, Swift J, Hsu JW, Alvey CM, Zoltick PW, Discher DE. "Marker of Self" CD47 on lentiviral vectors decreases macrophage-mediated clearance and increases delivery to SIRPA-expressing lung carcinoma tumors. Molecular Therapy. Methods & Clinical Development. 3: 16080. PMID 28053997 DOI: 10.1038/mtm.2016.80  0.76
2016 Irianto J, Xia Y, Pfeifer CR, Athirasala A, Ji J, Alvey C, Tewari M, Bennett RR, Harding SM, Liu AJ, Greenberg RA, Discher DE. DNA Damage Follows Repair Factor Depletion and Portends Genome Variation in Cancer Cells after Pore Migration. Current Biology : Cb. PMID 27989676 DOI: 10.1016/j.cub.2016.11.049  0.76
2016 Raab M, Discher DE. Matrix rigidity regulates the microtubule network polarization in migration. Cytoskeleton (Hoboken, N.J.). PMID 27935261 DOI: 10.1002/cm.21349  0.92
2016 Irianto J, Pfeifer CR, Bennett RR, Xia Y, Ivanovska IL, Liu AJ, Greenberg RA, Discher DE. Nuclear constriction segregates mobile nuclear proteins away from chromatin. Molecular Biology of the Cell. PMID 27798234 DOI: 10.1091/mbc.E16-06-0428  0.76
2016 Irianto J, Pfeifer CR, Ivanovska IL, Swift J, Discher DE. Nuclear lamins in cancer. Cellular and Molecular Bioengineering. 9: 258-267. PMID 27570565 DOI: 10.1007/s12195-016-0437-8  0.76
2016 Weinkopff T, Konradt C, Christian DA, Discher DE, Hunter CA, Scott P. Leishmania major Infection-Induced VEGF-A/VEGFR-2 Signaling Promotes Lymphangiogenesis That Controls Disease. Journal of Immunology (Baltimore, Md. : 1950). PMID 27474074 DOI: 10.4049/jimmunol.1600717  0.32
2016 Chiou KK, Rocks JW, Chen CY, Cho S, Merkus KE, Rajaratnam A, Robison P, Tewari M, Vogel K, Majkut SF, Prosser BL, Discher DE, Liu AJ. Mechanical signaling coordinates the embryonic heartbeat. Proceedings of the National Academy of Sciences of the United States of America. PMID 27457951 DOI: 10.1073/pnas.1520428113  0.72
2016 Irianto J, Pfeifer CR, Xia Y, Discher DE. SnapShot: Mechanosensing Matrix. Cell. 165: 1820-1820.e1. PMID 27315485 DOI: 10.1016/j.cell.2016.06.002  0.76
2016 Nair PR, Karthick SA, Spinler KR, Vakili MR, Lavasanifar A, Discher DE. Filomicelles from aromatic diblock copolymers increase paclitaxel-induced tumor cell death and aneuploidy compared with aliphatic copolymers. Nanomedicine (London, England). PMID 27177319 DOI: 10.2217/nnm-2016-0007  0.76
2016 Chin L, Xia Y, Discher DE, Janmey PA. Mechanotransduction in cancer Current Opinion in Chemical Engineering. 11: 77-84. DOI: 10.1016/j.coche.2016.01.011  0.4
2015 Discher DE, Ney PA. The reason sickle reticulocytes expose PS. Blood. 126: 1737-8. PMID 26450953 DOI: 10.1182/blood-2015-08-665117  1
2015 Sosale NG, Spinler KR, Alvey C, Discher DE. Macrophage engulfment of a cell or nanoparticle is regulated by unavoidable opsonization, a species-specific 'Marker of Self' CD47, and target physical properties. Current Opinion in Immunology. 35: 107-112. PMID 26172292 DOI: 10.1016/j.coi.2015.06.013  1
2015 Dingal PC, Bradshaw AM, Cho S, Raab M, Buxboim A, Swift J, Discher DE. Fractal heterogeneity in minimal matrix models of scars modulates stiff-niche stem-cell responses via nuclear exit of a mechanorepressor. Nature Materials. PMID 26168347 DOI: 10.1038/nmat4350  1
2015 Ivanovska IL, Shin JW, Swift J, Discher DE. Stem cell mechanobiology: diverse lessons from bone marrow. Trends in Cell Biology. PMID 26045259 DOI: 10.1016/j.tcb.2015.04.003  1
2015 Shin JW, Discher DE. Blood and immune cell engineering: Cytoskeletal contractility and nuclear rheology impact cell lineage and localization: Biophysical regulation of hematopoietic differentiation and trafficking. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 37: 633-42. PMID 25810145 DOI: 10.1002/bies.201400166  1
2015 Dasbiswas K, Majkut S, Discher DE, Safran SA. Substrate stiffness-modulated registry phase correlations in cardiomyocytes map structural order to coherent beating. Nature Communications. 6: 6085. PMID 25597833 DOI: 10.1038/ncomms7085  1
2015 Sosale NG, Rouhiparkouhi T, Bradshaw AM, Dimova R, Lipowsky R, Discher DE. Cell rigidity and shape override CD47's "self"-signaling in phagocytosis by hyperactivating myosin-II. Blood. 125: 542-52. PMID 25411427 DOI: 10.1182/blood-2014-06-585299  1
2015 Spinler KR, Shin JW, Lambert MP, Discher DE. Myosin-II repression favors pre/proplatelets but shear activation generates platelets and fails in macrothrombocytopenia. Blood. 125: 525-33. PMID 25395423 DOI: 10.1182/blood-2014-05-576462  1
2014 Dingal PC, Wells RG, Discher DE. Simple insoluble cues specify stem cell differentiation. Proceedings of the National Academy of Sciences of the United States of America. 111: 18104-5. PMID 25512554 DOI: 10.1073/pnas.1421562112  1
2014 Dingal PC, Discher DE. Systems mechanobiology: tension-inhibited protein turnover is sufficient to physically control gene circuits. Biophysical Journal. 107: 2734-43. PMID 25468352 DOI: 10.1016/j.bpj.2014.10.042  1
2014 Nair PR, Discher DE. 23. From stealthy, controlled release polymersomes to cylinder-shaped 'filomicelles' for imaging and delivery: Original research article: Self-porating polymersomes of PEG-PLA and PEG-PCL: hydrolysis-triggered controlled release vesicles, 2004. Journal of Controlled Release : Official Journal of the Controlled Release Society. 190: 72-4. PMID 25356496 DOI: 10.1016/j.jconrel.2014.07.035  1
2014 Buxboim A, Swift J, Irianto J, Spinler KR, Dingal PC, Athirasala A, Kao YR, Cho S, Harada T, Shin JW, Discher DE. Matrix elasticity regulates lamin-A,C phosphorylation and turnover with feedback to actomyosin. Current Biology : Cb. 24: 1909-17. PMID 25127216 DOI: 10.1016/j.cub.2014.07.001  1
2014 Swift J, Discher DE. The nuclear lamina is mechano-responsive to ECM elasticity in mature tissue. Journal of Cell Science. 127: 3005-15. PMID 24963133 DOI: 10.1242/jcs.149203  1
2014 Oltra NS, Nair P, Discher DE. From stealthy polymersomes and filomicelles to "self" Peptide-nanoparticles for cancer therapy. Annual Review of Chemical and Biomolecular Engineering. 5: 281-99. PMID 24910917 DOI: 10.1146/annurev-chembioeng-060713-040447  1
2014 Dingal PC, Discher DE. Combining insoluble and soluble factors to steer stem cell fate. Nature Materials. 13: 532-7. PMID 24845982 DOI: 10.1038/nmat3997  1
2014 Majkut S, Dingal PC, Discher DE. Stress sensitivity and mechanotransduction during heart development. Current Biology : Cb. 24: R495-501. PMID 24845682 DOI: 10.1016/j.cub.2014.04.027  1
2014 Dingal PC, Discher DE. Material control of stem cell differentiation: challenges in nano-characterization. Current Opinion in Biotechnology. 28: 46-50. PMID 24832074 DOI: 10.1016/j.copbio.2013.11.003  1
2014 Harada T, Swift J, Irianto J, Shin JW, Spinler KR, Athirasala A, Diegmiller R, Dingal PC, Ivanovska IL, Discher DE. Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival. The Journal of Cell Biology. 204: 669-82. PMID 24567359 DOI: 10.1083/jcb.201308029  1
2014 Shin JW, Buxboim A, Spinler KR, Swift J, Christian DA, Hunter CA, Léon C, Gachet C, Dingal PC, Ivanovska IL, Rehfeldt F, Chasis JA, Discher DE. Contractile forces sustain and polarize hematopoiesis from stem and progenitor cells. Cell Stem Cell. 14: 81-93. PMID 24268694 DOI: 10.1016/j.stem.2013.10.009  1
2014 Harada T, Swift J, Irianto J, Shin JW, Spinler KR, Athirasala A, Diegmiller R, Dingal PCDP, Ivanovska IL, Discher DE. Nuclear lamin stiffness is a barrier to 3D-migration, but softness can limit survival Proceedings of the Ieee Annual Northeast Bioengineering Conference, Nebec. 2014. DOI: 10.1109/NEBEC.2014.6972810  1
2014 Buxboim A, Swift J, Ivanovska IL, Irianto J, Discher DE. How deeply cells feel? Proceedings of the Ieee Annual Northeast Bioengineering Conference, Nebec. 2014. DOI: 10.1109/NEBEC.2014.6972744  1
2014 Peppas NA, Duncan R, Wnek GE, Hoffman AS, Gao GH, Kim SW, Lee DS, Hadjiargyrou M, Touitou E, Ainbinder D, Mumper R, Rolland A, Niidome T, Labhasetwar V, Liu S, ... ... Discher D, et al. Highly cited research articles in Journal of Controlled Release: Commentaries and perspectives by authors Journal of Controlled Release. 190: 29-74. DOI: 10.1016/S0168-3659(14)00482-9  1
2013 Swift J, Harada T, Buxboim A, Shin JW, Tang HY, Speicher DW, Discher DE. Label-free mass spectrometry exploits dozens of detected peptides to quantify lamins in wildtype and knockdown cells. Nucleus (Austin, Tex.). 4: 450-9. PMID 24448480 DOI: 10.4161/nucl.27413  1
2013 Majkut S, Idema T, Swift J, Krieger C, Liu A, Discher DE. Heart-specific stiffening in early embryos parallels matrix and myosin expression to optimize beating. Current Biology : Cb. 23: 2434-9. PMID 24268417 DOI: 10.1016/j.cub.2013.10.057  1
2013 Shin JW, Spinler KR, Swift J, Chasis JA, Mohandas N, Discher DE. Lamins regulate cell trafficking and lineage maturation of adult human hematopoietic cells. Proceedings of the National Academy of Sciences of the United States of America. 110: 18892-7. PMID 24191023 DOI: 10.1073/pnas.1304996110  1
2013 Swift J, Ivanovska IL, Buxboim A, Harada T, Dingal PC, Pinter J, Pajerowski JD, Spinler KR, Shin JW, Tewari M, Rehfeldt F, Speicher DW, Discher DE. Nuclear lamin-A scales with tissue stiffness and enhances matrix-directed differentiation. Science (New York, N.Y.). 341: 1240104. PMID 23990565 DOI: 10.1126/science.1240104  1
2013 Suzuki A, Shin JW, Wang Y, Min SH, Poncz M, Choi JK, Discher DE, Carpenter CL, Lian L, Zhao L, Wang Y, Abrams CS. RhoA is essential for maintaining normal megakaryocyte ploidy and platelet generation. Plos One. 8: e69315. PMID 23935982 DOI: 10.1371/journal.pone.0069315  1
2013 Shin JW, Swift J, Ivanovska I, Spinler KR, Buxboim A, Discher DE. Mechanobiology of bone marrow stem cells: from myosin-II forces to compliance of matrix and nucleus in cell forms and fates. Differentiation; Research in Biological Diversity. 86: 77-86. PMID 23790394 DOI: 10.1016/j.diff.2013.05.001  1
2013 Irianto J, Swift J, Martins RP, McPhail GD, Knight MM, Discher DE, Lee DA. Osmotic challenge drives rapid and reversible chromatin condensation in chondrocytes. Biophysical Journal. 104: 759-69. PMID 23442954 DOI: 10.1016/j.bpj.2013.01.006  1
2013 Rodriguez PL, Harada T, Christian DA, Pantano DA, Tsai RK, Discher DE. Minimal "Self" peptides that inhibit phagocytic clearance and enhance delivery of nanoparticles. Science (New York, N.Y.). 339: 971-5. PMID 23430657 DOI: 10.1126/science.1229568  1
2013 Rouhiparkouhi T, Weikl TR, Discher DE, Lipowsky R. Adhesion-induced phase behavior of two-component membranes and vesicles. International Journal of Molecular Sciences. 14: 2203-29. PMID 23340655 DOI: 10.3390/ijms14012203  1
2013 Spinler K, Tian A, Christian DA, Pantano DA, Baumgart T, Discher DE. Dynamic domains in polymersomes: mixtures of polyanionic and neutral diblocks respond more rapidly to changes in calcium than to pH. Langmuir : the Acs Journal of Surfaces and Colloids. 29: 7499-508. PMID 23327600 DOI: 10.1021/la304602e  1
2013 Baumann BC, Kao GD, Mahmud A, Harada T, Swift J, Chapman C, Xu X, Discher DE, Dorsey JF. Enhancing the efficacy of drug-loaded nanocarriers against brain tumors by targeted radiation therapy. Oncotarget. 4: 64-79. PMID 23296073  1
2013 Oltra NS, Swift J, Mahmud A, Rajagopal K, Loverde SM, Discher DE. Filomicelles in nanomedicine-from flexible, fragmentable, and ligand-targetable drug carrier designs to combination therapy for brain tumors Journal of Materials Chemistry B. 1: 5177-5185. DOI: 10.1039/c3tb20431f  1
2013 Shinoda W, Discher DE, Klein ML, Loverde SM. Probing the structure of PEGylated-lipid assemblies by coarse-grained molecular dynamics Soft Matter. 9: 11549-11556. DOI: 10.1039/c3sm52290c  1
2013 Lipowsky R, Rouhiparkouhi T, Discher DE, Weikl TR. Domain formation in cholesterol-phospholipid membranes exposed to adhesive surfaces or environments Soft Matter. 9: 8438-8453. DOI: 10.1039/c3sm50712b  1
2013 Sancho Oltra N, Loverde SM, Harada T, Mahmud A, Rajagopal K, Discher DE. Polymersomes and filomicelles Fundamentals of Pharmaceutical Nanoscience. 183-210. DOI: 10.1007/978-1-4614-9164-4_8  0.4
2012 Raab M, Swift J, Dingal PC, Shah P, Shin JW, Discher DE. Crawling from soft to stiff matrix polarizes the cytoskeleton and phosphoregulates myosin-II heavy chain. The Journal of Cell Biology. 199: 669-83. PMID 23128239 DOI: 10.1083/jcb.201205056  1
2012 Ma Z, Discher DE, Finkel TH. Mechanical force in T cell receptor signal initiation. Frontiers in Immunology. 3: 217. PMID 22833746 DOI: 10.3389/fimmu.2012.00217  1
2012 Shin JW, Discher DE. Cell culture: Soft gels select tumorigenic cells. Nature Materials. 11: 662-3. PMID 22825018 DOI: 10.1038/nmat3388  1
2012 Majkut SF, Discher DE. Cardiomyocytes from late embryos and neonates do optimal work and striate best on substrates with tissue-level elasticity: metrics and mathematics. Biomechanics and Modeling in Mechanobiology. 11: 1219-25. PMID 22752667 DOI: 10.1007/s10237-012-0413-8  1
2012 Sosale N, Discher DE. Marker-of-self becomes marker-of-senescence. Blood. 119: 5343-4. PMID 22679336 DOI: 10.1182/blood-2012-04-418608  1
2012 Swift J, Discher DE. Subcellular organization: change of phase in partitioning the cellular milieu. Current Biology : Cb. 22: R188-90. PMID 22440801 DOI: 10.1016/j.cub.2012.02.008  1
2012 Rehfeldt F, Brown AE, Raab M, Cai S, Zajac AL, Zemel A, Discher DE. Hyaluronic acid matrices show matrix stiffness in 2D and 3D dictates cytoskeletal order and myosin-II phosphorylation within stem cells. Integrative Biology : Quantitative Biosciences From Nano to Macro. 4: 422-30. PMID 22344328 DOI: 10.1039/c2ib00150k  1
2012 Loverde SM, Klein ML, Discher DE. Nanoparticle shape improves delivery: rational coarse grain molecular dynamics (rCG-MD) of taxol in worm-like PEG-PCL micelles. Advanced Materials (Deerfield Beach, Fla.). 24: 3823-30. PMID 22105885 DOI: 10.1002/adma.201103192  1
2012 Raab MD, Swift J, Discher DE. Matrices engineered with gradients in rigidity guide stem cell migration and polarize the cytoskeleton 2012 38th Annual Northeast Bioengineering Conference, Nebec 2012. 303-304. DOI: 10.1109/NEBC.2012.6207085  1
2012 Raab MD, Swift J, Discher DE. Matrices engineered with gradients in rigidity guide stem cell migration and polarize the cytoskeleton 2012 38th Annual Northeast Bioengineering Conference, Nebec 2012. 303-304. DOI: 10.1109/NEBC.2012.6207085  0.76
2012 Spinler K, Shin JW, Discher DE. Platelet generation under shear force modulated by site-specific phosphorylation of myosin-IIA heavy chain 2012 38th Annual Northeast Bioengineering Conference, Nebec 2012. 217-218. DOI: 10.1109/NEBC.2012.6207041  1
2012 Spinler K, Shin JW, Discher DE. Platelet generation under shear force modulated by site-specific phosphorylation of myosin-IIA heavy chain 2012 38th Annual Northeast Bioengineering Conference, Nebec 2012. 217-218. DOI: 10.1109/NEBC.2012.6207041  0.76
2012 Oltra NS, Loverde SM, Harada T, Mahmud A, Rajagopal K, Discher DE. Degradable poly(ethylene oxide)-blockpolycaprolactone worm-like micelles: From phase transitions and molecular simulation to persistent circulation and shrinking tumors Acs Symposium Series. 1114: 255-285. DOI: 10.1021/bk-2012-1114.ch016  1
2012 Oltra NS, Loverde SM, Harada T, Mahmud A, Rajagopal K, Discher DE. Degradable poly(ethylene oxide)-blockpolycaprolactone worm-like micelles: From phase transitions and molecular simulation to persistent circulation and shrinking tumors Acs Symposium Series. 1114: 255-285. DOI: 10.1021/bk-2012-1114.ch016  0.76
2012 Buxboim A, Discher DE. Mechanical Interactions between Cells and Tissues Polymer Science: a Comprehensive Reference, 10 Volume Set. 9: 201-209. DOI: 10.1016/B978-0-444-53349-4.00242-9  1
2012 Buxboim A, Discher DE. Mechanical Interactions between Cells and Tissues Polymer Science: a Comprehensive Reference, 10 Volume Set. 9: 201-209. DOI: 10.1016/B978-0-444-53349-4.00242-9  0.32
2011 Ellenbroek WG, Wang YH, Christian DA, Discher DE, Janmey PA, Liu AJ. Divalent cation-dependent formation of electrostatic PIP2 clusters in lipid monolayers. Biophysical Journal. 101: 2178-84. PMID 22067156 DOI: 10.1016/j.bpj.2011.09.039  1
2011 Shuvaev VV, Ilies MA, Simone E, Zaitsev S, Kim Y, Cai S, Mahmud A, Dziubla T, Muro S, Discher DE, Muzykantov VR. Endothelial targeting of antibody-decorated polymeric filomicelles. Acs Nano. 5: 6991-9. PMID 21838300 DOI: 10.1021/nn2015453  1
2011 Mahmud A, Discher DE. Lung vascular targeting through inhalation delivery: insight from filamentous viruses and other shapes. Iubmb Life. 63: 607-12. PMID 21721102 DOI: 10.1002/iub.481  1
2011 Yoo JW, Irvine DJ, Discher DE, Mitragotri S. Bio-inspired, bioengineered and biomimetic drug delivery carriers. Nature Reviews. Drug Discovery. 10: 521-35. PMID 21720407 DOI: 10.1038/nrd3499  1
2011 Shin JW, Swift J, Spinler KR, Discher DE. Myosin-II inhibition and soft 2D matrix maximize multinucleation and cellular projections typical of platelet-producing megakaryocytes. Proceedings of the National Academy of Sciences of the United States of America. 108: 11458-63. PMID 21709232 DOI: 10.1073/pnas.1017474108  1
2011 Friedrich BM, Buxboim A, Discher DE, Safran SA. Striated acto-myosin fibers can reorganize and register in response to elastic interactions with the matrix. Biophysical Journal. 100: 2706-15. PMID 21641316 DOI: 10.1016/j.bpj.2011.04.050  1
2011 Krieger CC, An X, Tang HY, Mohandas N, Speicher DW, Discher DE. Cysteine shotgun-mass spectrometry (CS-MS) reveals dynamic sequence of protein structure changes within mutant and stressed cells. Proceedings of the National Academy of Sciences of the United States of America. 108: 8269-74. PMID 21527722 DOI: 10.1073/pnas.1018887108  1
2011 Pantano DA, Klein ML, Discher DE, Moore PB. Morphologies of charged diblock copolymers simulated with a neutral coarse-grained model. The Journal of Physical Chemistry. B. 115: 4689-95. PMID 21462939 DOI: 10.1021/jp201085c  0.44
2011 Stachelek SJ, Finley MJ, Alferiev IS, Wang F, Tsai RK, Eckells EC, Tomczyk N, Connolly JM, Discher DE, Eckmann DM, Levy RJ. The effect of CD47 modified polymer surfaces on inflammatory cell attachment and activation. Biomaterials. 32: 4317-26. PMID 21429575 DOI: 10.1016/j.biomaterials.2011.02.053  1
2011 Harada T, Discher DE. Materials science: Bubble wrap of cell-like aggregates. Nature. 471: 172-3. PMID 21390121 DOI: 10.1038/471172a  1
2011 Purohit PK, Litvinov RI, Brown AE, Discher DE, Weisel JW. Protein unfolding accounts for the unusual mechanical behavior of fibrin networks. Acta Biomaterialia. 7: 2374-83. PMID 21342665 DOI: 10.1016/j.actbio.2011.02.026  1
2011 Sen S, Tewari M, Zajac A, Barton E, Sweeney HL, Discher DE. Upregulation of paxillin and focal adhesion signaling follows Dystroglycan Complex deletions and promotes a hypertensive state of differentiation. European Journal of Cell Biology. 90: 249-60. PMID 20663583 DOI: 10.1016/j.ejcb.2010.06.005  1
2011 Pantano DA, Moore PB, Klein ML, Discher DE. Raft registration across bilayers in a molecularly detailed model Soft Matter. 7: 8182-8191. DOI: 10.1039/c1sm05490b  1
2011 Pantano DA, Moore PB, Klein ML, Discher DE. Raft registration across bilayers in a molecularly detailed model Soft Matter. 7: 8182-8191. DOI: 10.1039/c1sm05490b  0.44
2011 Loverde SM, Pantano DA, Christian DA, Mahmud A, Klein ML, Discher DE. Curvature, rigidity, and pattern formation in functional polymer micelles and vesicles-From dynamic visualization to molecular simulation Current Opinion in Solid State and Materials Science. 15: 277-284. DOI: 10.1016/j.cossms.2011.06.003  1
2011 Loverde SM, Pantano DA, Christian DA, Mahmud A, Klein ML, Discher DE. Curvature, rigidity, and pattern formation in functional polymer micelles and vesicles-From dynamic visualization to molecular simulation Current Opinion in Solid State and Materials Science. 15: 277-284. DOI: 10.1016/j.cossms.2011.06.003  0.64
2011 Discher DE, Ivanovska I, Buxboim A. Matrix elasticity directs stem cell fates - How deeply can cells feel? Ifmbe Proceedings. 30: 21-22. DOI: 10.1007/978-3-642-19044-5_6  1
2011 Discher DE, Ivanovska I, Buxboim A. Matrix elasticity directs stem cell fates - How deeply can cells feel? Ifmbe Proceedings. 30: 21-22. DOI: 10.1007/978-3-642-19044-5_6  0.32
2010 Christian DA, Garbuzenko OB, Minko T, Discher DE. Polymer Vesicles with a Red Cell-like Surface Charge: Microvascular Imaging and in vivo Tracking with Near-Infrared Fluorescence. Macromolecular Rapid Communications. 31: 135-41. PMID 21590885 DOI: 10.1002/marc.200900589  1
2010 Rajagopal K, Mahmud A, Christian DA, Pajerowski JD, Brown AE, Loverde SM, Discher DE. Curvature-coupled hydration of Semicrystalline Polymer Amphiphiles yields flexible Worm Micelles but favors rigid Vesicles: polycaprolactone-based block copolymers. Macromolecules. 43: 9736-9746. PMID 21499509 DOI: 10.1021/ma101316w  1
2010 Raab M, Shin JW, Discher DE. Matrix elasticity in vitro controls muscle stem cell fate in vivo. Stem Cell Research & Therapy. 1: 38. PMID 21144011 DOI: 10.1186/scrt38  1
2010 Krieger CC, Bhasin N, Tewari M, Brown AE, Safer D, Sweeney HL, Discher DE. Exon-skipped dystrophins for treatment of Duchenne muscular dystrophy: mass spectrometry mapping of most exons and cooperative domain designs based on single molecule mechanics. Cytoskeleton (Hoboken, N.J.). 67: 796-807. PMID 20886611 DOI: 10.1002/cm.20489  1
2010 Ivanovska I, Swift J, Harada T, Pajerowski JD, Discher DE. Physical plasticity of the nucleus and its manipulation. Methods in Cell Biology. 98: 207-20. PMID 20816236 DOI: 10.1016/S0091-679X(10)98009-6  1
2010 Buxboim A, Discher DE. Stem cells feel the difference. Nature Methods. 7: 695-7. PMID 20805798 DOI: 10.1038/nmeth0910-695  1
2010 Loverde SM, Ortiz V, Kamien RD, Klein ML, Discher DE. Curvature-driven molecular demixing in the budding and breakup of mixed component Worm-like Micelles. Soft Matter. 6: 1419-1425. PMID 20668645 DOI: 10.1039/b919581e  1
2010 Zemel A, Rehfeldt F, Brown AE, Discher DE, Safran SA. Optimal matrix rigidity for stress fiber polarization in stem cells. Nature Physics. 6: 468-473. PMID 20563235 DOI: 10.1038/nphys1613  1
2010 Zemel A, Rehfeldt F, Brown AE, Discher DE, Safran SA. Cell shape, spreading symmetry and the polarization of stress-fibers in cells. Journal of Physics. Condensed Matter : An Institute of Physics Journal. 22: 194110. PMID 20458358 DOI: 10.1088/0953-8984/22/19/194110  1
2010 Buxboim A, Rajagopal K, Brown AE, Discher DE. How deeply cells feel: methods for thin gels. Journal of Physics. Condensed Matter : An Institute of Physics Journal. 22: 194116. PMID 20454525 DOI: 10.1088/0953-8984/22/19/194116  1
2010 Chaudhuri T, Rehfeldt F, Sweeney HL, Discher DE. Preparation of collagen-coated gels that maximize in vitro myogenesis of stem cells by matching the lateral elasticity of in vivo muscle. Methods in Molecular Biology (Clifton, N.J.). 621: 185-202. PMID 20405368 DOI: 10.1007/978-1-60761-063-2_13  1
2010 Tsai RK, Rodriguez PL, Discher DE. Self inhibition of phagocytosis: the affinity of 'marker of self' CD47 for SIRPalpha dictates potency of inhibition but only at low expression levels. Blood Cells, Molecules & Diseases. 45: 67-74. PMID 20299253 DOI: 10.1016/j.bcmd.2010.02.016  1
2010 Buxboim A, Ivanovska IL, Discher DE. Matrix elasticity, cytoskeletal forces and physics of the nucleus: how deeply do cells 'feel' outside and in? Journal of Cell Science. 123: 297-308. PMID 20130138 DOI: 10.1242/jcs.041186  1
2010 Rajagopal K, Christian DA, Harada T, Tian A, Discher DE. Polymersomes and wormlike micelles made fluorescent by direct modifications of block copolymer amphiphiles International Journal of Polymer Science. 2010. DOI: 10.1155/2010/379286  1
2010 Rajagopal K, Christian DA, Harada T, Tian A, Discher DE. Polymersomes and wormlike micelles made fluorescent by direct modifications of block copolymer amphiphiles International Journal of Polymer Science. 2010. DOI: 10.1155/2010/379286  0.76
2010 Cai S, Christian DA, Tewari M, Minko T, Discher DE. Anti-cancer polymersomes Rsc Nanoscience and Nanotechnology. 300-312.  1
2010 Cai S, Christian DA, Tewari M, Minko T, Discher DE. Anti-cancer polymersomes Rsc Nanoscience and Nanotechnology. 300-312.  0.72
2010 Thomas WE, Discher DE, Prasad Shastri V. Mechanical regulation of cells by materials and tissues Mrs Bulletin. 35: 578-583.  1
2009 Sen S, Engler AJ, Discher DE. Matrix strains induced by cells: Computing how far cells can feel. Cellular and Molecular Bioengineering. 2: 39-48. PMID 20582230 DOI: 10.1007/s12195-009-0052-z  1
2009 Discher DE. The Foldome in cellular force transduction. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 2009: 3341-2. PMID 19964073 DOI: 10.1109/IEMBS.2009.5333197  1
2009 Brown AE, Discher DE. Conformational changes and signaling in cell and matrix physics. Current Biology : Cb. 19: R781-9. PMID 19906580 DOI: 10.1016/j.cub.2009.06.054  1
2009 Christian DA, Tian A, Ellenbroek WG, Levental I, Rajagopal K, Janmey PA, Liu AJ, Baumgart T, Discher DE. Spotted vesicles, striped micelles and Janus assemblies induced by ligand binding. Nature Materials. 8: 843-9. PMID 19734886 DOI: 10.1038/nmat2512  1
2009 Brown AE, Litvinov RI, Discher DE, Purohit PK, Weisel JW. Multiscale mechanics of fibrin polymer: gel stretching with protein unfolding and loss of water. Science (New York, N.Y.). 325: 741-4. PMID 19661428 DOI: 10.1126/science.1172484  1
2009 Levental I, Christian DA, Wang YH, Madara JJ, Discher DE, Janmey PA. Calcium-dependent lateral organization in phosphatidylinositol 4,5-bisphosphate (PIP2)- and cholesterol-containing monolayers. Biochemistry. 48: 8241-8. PMID 19630438 DOI: 10.1021/bi9007879  1
2009 Tenney RM, Discher DE. Stem cells, microenvironment mechanics, and growth factor activation. Current Opinion in Cell Biology. 21: 630-5. PMID 19615877 DOI: 10.1016/j.ceb.2009.06.003  1
2009 Discher DE, Mooney DJ, Zandstra PW. Growth factors, matrices, and forces combine and control stem cells. Science (New York, N.Y.). 324: 1673-7. PMID 19556500 DOI: 10.1126/science.1171643  1
2009 Simone EA, Dziubla TD, Discher DE, Muzykantov VR. Filamentous polymer nanocarriers of tunable stiffness that encapsulate the therapeutic enzyme catalase. Biomacromolecules. 10: 1324-30. PMID 19385657 DOI: 10.1021/bm900189x  1
2009 Brown AE, Hategan A, Safer D, Goldman YE, Discher DE. Cross-correlated TIRF/AFM reveals asymmetric distribution of force-generating heads along self-assembled, "synthetic" myosin filaments. Biophysical Journal. 96: 1952-60. PMID 19254555 DOI: 10.1016/j.bpj.2008.11.032  1
2009 Christian DA, Cai S, Garbuzenko OB, Harada T, Zajac AL, Minko T, Discher DE. Flexible filaments for in vivo imaging and delivery: persistent circulation of filomicelles opens the dosage window for sustained tumor shrinkage. Molecular Pharmaceutics. 6: 1343-52. PMID 19249859 DOI: 10.1021/mp900022m  1
2009 Kim Y, Tewari M, Pajerowski JD, Cai S, Sen S, Williams JH, Williams J, Sirsi SR, Sirsi S, Lutz GJ, Lutz G, Discher DE. Polymersome delivery of siRNA and antisense oligonucleotides. Journal of Controlled Release : Official Journal of the Controlled Release Society. 134: 132-40. PMID 19084037 DOI: 10.1016/j.jconrel.2008.10.020  1
2009 Christian DA, Cai S, Bowen DM, Kim Y, Pajerowski JD, Discher DE. Polymersome carriers: from self-assembly to siRNA and protein therapeutics. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft FüR Pharmazeutische Verfahrenstechnik E.V. 71: 463-74. PMID 18977437 DOI: 10.1016/j.ejpb.2008.09.025  1
2009 Tong R, Christian DA, Tang L, Cabral H, Baker JR, Kataoka K, Discher DE, Cheng J. Nanopolymeric therapeutics Mrs Bulletin. 34: 422-431.  1
2009 Tong R, Christian DA, Tang L, Cabral H, Baker JR, Kataoka K, Discher DE, Cheng J. Nanopolymeric therapeutics Mrs Bulletin. 34: 422-431.  0.64
2008 Engler AJ, Carag-Krieger C, Johnson CP, Raab M, Tang HY, Speicher DW, Sanger JW, Sanger JM, Discher DE. Embryonic cardiomyocytes beat best on a matrix with heart-like elasticity: scar-like rigidity inhibits beating. Journal of Cell Science. 121: 3794-802. PMID 18957515 DOI: 10.1242/jcs.029678  1
2008 Zajac AL, Discher DE. Cell differentiation through tissue elasticity-coupled, myosin-driven remodeling. Current Opinion in Cell Biology. 20: 609-15. PMID 18926907 DOI: 10.1016/j.ceb.2008.09.006  1
2008 Tsai R, Rodriguez P, Discher DE. Cys shotgun labeling of macrophages adhering to and engulfing Ig-opsonized cells. Transfusion Clinique Et Biologique : Journal De La SociéTé FrançAise De Transfusion Sanguine. 15: 58-61. PMID 18499497 DOI: 10.1016/j.tracli.2008.04.011  1
2008 Wells RG, Discher DE. Matrix elasticity, cytoskeletal tension, and TGF-beta: the insoluble and soluble meet. Science Signaling. 1: pe13. PMID 18334714 DOI: 10.1126/stke.110pe13  1
2008 Tsai RK, Discher DE. Inhibition of "self" engulfment through deactivation of myosin-II at the phagocytic synapse between human cells. The Journal of Cell Biology. 180: 989-1003. PMID 18332220 DOI: 10.1083/jcb.200708043  1
2008 Börner HG, Smarsly BM, Hentschel J, Rank A, Schubert R, Geng Y, Discher DE, Hellweg T, Brandt A. Organization of self-assembled peptide-polymer nanofibers in solution Macromolecules. 41: 1430-1437. DOI: 10.1021/ma0714060  1
2008 Harada T, Rajagopal K, Discher DE. Cell uptake of morphologically distinct polymer micelles Aiche Annual Meeting, Conference Proceedings 1
2008 Harada T, Rajagopal K, Discher DE. Cell uptake of morphologically distinct polymer micelles Aiche Annual Meeting, Conference Proceedings 0.76
2008 Rajagopal K, Discher DE. Reductively degradeable polymeric assemblies constructed from polyethyleneoxide-S-S-polycaprolactone diblock copolymer for applications in drug delivery Aiche Annual Meeting, Conference Proceedings 1
2008 Rajagopal K, Discher DE. Reductively degradeable polymeric assemblies constructed from polyethyleneoxide-S-S-polycaprolactone diblock copolymer for applications in drug delivery Aiche Annual Meeting, Conference Proceedings 0.4
2008 Discher DE. Getting around the innate immune response - Nanoscale insights into shape, flexibility, and the 'marker of Self' system Aiche Annual Meeting, Conference Proceedings 1
2008 Rajagopal K, Pajerowski JD, Discher DE. Supramolecular morphologies from polyethyleneoxide-B-polycaprolactone diblock copolymers and effect of nanoscale confinement on polycaprolactone crystallization Aiche Annual Meeting, Conference Proceedings 1
2008 Rajagopal K, Pajerowski JD, Discher DE. Supramolecular morphologies from polyethyleneoxide-B-polycaprolactone diblock copolymers and effect of nanoscale confinement on polycaprolactone crystallization Aiche Annual Meeting, Conference Proceedings 1
2008 Christian DA, Bowen DM, Dunn RJ, Discher DE. Anionic nano-polymersomes for enhanced circulation kinetics in vivo Aiche Annual Meeting, Conference Proceedings 1
2008 Vijayan K, Brown AE, Rajagopal K, Discher DE. Glassy worms: From rheology to solvent tuned flexibility and nano-molded rods Aiche Annual Meeting, Conference Proceedings 1
2008 Pajerowski JD, Rajagopal K, Discher DE. Solution studies of protein folding using a site-specific probe of cysteine accessibility Aiche Annual Meeting, Conference Proceedings 1
2008 Christian DA, Rajagopal K, Srinivas G, Klein ML, Discher DE. Nanoparticle incorporation and aggregation in block copolymer worm-like micelles Aiche Annual Meeting, Conference Proceedings 1
2008 Christian DA, Rajagopal K, Srinivas G, Klein ML, Discher DE. Nanoparticle incorporation and aggregation in block copolymer worm-like micelles Aiche Annual Meeting, Conference Proceedings 0.64
2008 Raab M, Rajagopal K, Rehfeldt F, Tewari M, Wang C, Discher DE. Elastic niches and capillaries tuned for 3D matrix control of mesenchymal stem cell differentiation Aiche Annual Meeting, Conference Proceedings 1
2008 Raab M, Rajagopal K, Rehfeldt F, Tewari M, Wang C, Discher DE. Elastic niches and capillaries tuned for 3D matrix control of mesenchymal stem cell differentiation Aiche Annual Meeting, Conference Proceedings 0.92
2008 Tsai R, Rodriguez P, Discher DE. 'Marker of Self' proteins on synthetics- Exploiting the body's own system of distinguishing foreign from self Aiche Annual Meeting, Conference Proceedings 1
2007 Discher DE, Ortiz V, Srinivas G, Klein ML, Kim Y, Christian D, Cai S, Photos P, Ahmed F. Emerging Applications of Polymersomes in Delivery: from Molecular Dynamics to Shrinkage of Tumors. Progress in Polymer Science. 32: 838-857. PMID 24692840 DOI: 10.1016/j.progpolymsci.2007.05.011  1
2007 Geng Y, Dalhaimer P, Cai S, Tsai R, Tewari M, Minko T, Discher DE. Shape effects of filaments versus spherical particles in flow and drug delivery. Nature Nanotechnology. 2: 249-55. PMID 18654271 DOI: 10.1038/nnano.2007.70  1
2007 Engler AJ, Sweeney HL, Discher DE, Schwarzbauer JE. Extracellular matrix elasticity directs stem cell differentiation. Journal of Musculoskeletal & Neuronal Interactions. 7: 335. PMID 18094500  1
2007 Simone EA, Dziubla TD, Colon-Gonzalez F, Discher DE, Muzykantov VR. Effect of polymer amphiphilicity on loading of a therapeutic enzyme into protective filamentous and spherical polymer nanocarriers. Biomacromolecules. 8: 3914-21. PMID 18038999 DOI: 10.1021/bm700888h  1
2007 Rehfeldt F, Engler AJ, Eckhardt A, Ahmed F, Discher DE. Cell responses to the mechanochemical microenvironment--implications for regenerative medicine and drug delivery. Advanced Drug Delivery Reviews. 59: 1329-39. PMID 17900747 DOI: 10.1016/j.addr.2007.08.007  1
2007 Pajerowski JD, Dahl KN, Zhong FL, Sammak PJ, Discher DE. Physical plasticity of the nucleus in stem cell differentiation. Proceedings of the National Academy of Sciences of the United States of America. 104: 15619-24. PMID 17893336 DOI: 10.1073/pnas.0702576104  1
2007 Picart C, Discher DE. Materials science: embedded shells decalcified. Nature. 448: 879-80. PMID 17713523 DOI: 10.1038/448879a  1
2007 Johnson CP, Tang HY, Carag C, Speicher DW, Discher DE. Forced unfolding of proteins within cells. Science (New York, N.Y.). 317: 663-6. PMID 17673662 DOI: 10.1126/science.1139857  1
2007 Engler AJ, Rehfeldt F, Sen S, Discher DE. Microtissue elasticity: measurements by atomic force microscopy and its influence on cell differentiation. Methods in Cell Biology. 83: 521-45. PMID 17613323 DOI: 10.1016/S0091-679X(07)83022-6  1
2007 Lammerding J, Dahl KN, Discher DE, Kamm RD. Nuclear mechanics and methods. Methods in Cell Biology. 83: 269-94. PMID 17613312 DOI: 10.1016/S0091-679X(07)83011-1  1
2007 Frey MT, Engler A, Discher DE, Lee J, Wang YL. Microscopic methods for measuring the elasticity of gel substrates for cell culture: microspheres, microindenters, and atomic force microscopy. Methods in Cell Biology. 83: 47-65. PMID 17613304 DOI: 10.1016/S0091-679X(07)83003-2  1
2007 Cai S, Vijayan K, Cheng D, Lima EM, Discher DE. Micelles of different morphologies--advantages of worm-like filomicelles of PEO-PCL in paclitaxel delivery. Pharmaceutical Research. 24: 2099-109. PMID 17564817 DOI: 10.1007/s11095-007-9335-z  1
2007 Johnson CP, Gaetani M, Ortiz V, Bhasin N, Harper S, Gallagher PG, Speicher DW, Discher DE. Pathogenic proline mutation in the linker between spectrin repeats: disease caused by spectrin unfolding. Blood. 109: 3538-43. PMID 17192394 DOI: 10.1182/blood-2006-07-038588  1
2007 Brown AE, Litvinov RI, Discher DE, Weisel JW. Forced unfolding of coiled-coils in fibrinogen by single-molecule AFM. Biophysical Journal. 92: L39-41. PMID 17172299 DOI: 10.1529/biophysj.106.101261  1
2007 Subramanian S, Boder ET, Discher DE. Phylogenetic divergence of CD47 interactions with human signal regulatory protein alpha reveals locus of species specificity. Implications for the binding site. The Journal of Biological Chemistry. 282: 1805-18. PMID 17098740 DOI: 10.1074/jbc.M603923200  1
2007 Photos PJ, Bermudez H, Aranda-Espinoza H, Shillcock J, Discher DE. Nuclear pores and membrane holes: Generic models for confined chains and entropic barriers in pore stabilization Soft Matter. 3: 364-371. DOI: 10.1039/b611412c  1
2007 Rehfeldt F, Discher DE. Biophysics: Cell dipoles feel their way Nature Physics. 3: 592-593. DOI: 10.1038/nphys712  1
2007 Dalhaimer P, Discher DE, Lubensky TC. Crosslinked actin networks show liquid crystal elastomer behaviour, including soft-mode elasticity Nature Physics. 3: 354-360. DOI: 10.1038/nphys567  1
2007 Wang YL, Discher DE. Preface Methods in Cell Biology. 83: XIX-XX. DOI: 10.1016/S0091-679X(07)83026-3  1
2007 Discher DE, Dalhaimer P. Soft filaments circulate longer than spherical particles - Shape effects in flow and drug delivery Proceedings of the Asme Summer Bioengineering Conference 2007, Sbc 2007. 125-126.  1
2007 Discher DE, Johnson C. Alternative splicing for mechanical resilience - The softening effect of filamin's hinge Proceedings of the Asme Summer Bioengineering Conference 2007, Sbc 2007. 789-790.  1
2006 Kim Y, Tewari M, Pajeroski DJ, Sen S, Jason W, Sirsi S, Lutz G, Discher DE. Efficient nuclear delivery and nuclear body localization of antisense oligo-nucleotides using degradable polymersomes. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 1: 4350-3. PMID 17947079 DOI: 10.1109/IEMBS.2006.259861  1
2006 Geng Y, Discher DE, Justynska J, Schlaad H. Grafting short peptides onto polybutadiene-block-poly(ethylene oxide): a platform for self-assembling hybrid amphiphiles. Angewandte Chemie (International Ed. in English). 45: 7578-81. PMID 17054301 DOI: 10.1002/anie.200602739  1
2006 Ahmed F, Pakunlu RI, Brannan A, Bates F, Minko T, Discher DE. Biodegradable polymersomes loaded with both paclitaxel and doxorubicin permeate and shrink tumors, inducing apoptosis in proportion to accumulated drug. Journal of Controlled Release : Official Journal of the Controlled Release Society. 116: 150-8. PMID 16942814 DOI: 10.1016/j.jconrel.2006.07.012  1
2006 Engler AJ, Sen S, Sweeney HL, Discher DE. Matrix elasticity directs stem cell lineage specification. Cell. 126: 677-89. PMID 16923388 DOI: 10.1016/j.cell.2006.06.044  1
2006 Discher DE, Ahmed F. Polymersomes. Annual Review of Biomedical Engineering. 8: 323-41. PMID 16834559 DOI: 10.1146/annurev.bioeng.8.061505.095838  1
2006 Ahmed F, Pakunlu RI, Srinivas G, Brannan A, Bates F, Klein ML, Minko T, Discher DE. Shrinkage of a rapidly growing tumor by drug-loaded polymersomes: pH-triggered release through copolymer degradation. Molecular Pharmaceutics. 3: 340-50. PMID 16749866 DOI: 10.1021/mp050103u  1
2006 Subramanian S, Tsai R, Sen S, Dahl KN, Discher DE. Membrane mobility and clustering of Integrin Associated Protein (IAP, CD47)--major differences between mouse and man and implications for signaling. Blood Cells, Molecules & Diseases. 36: 364-72. PMID 16697668 DOI: 10.1016/j.bcmd.2006.01.012  1
2006 Discher DE, Bhasin N, Johnson CP. Covalent chemistry on distended proteins. Proceedings of the National Academy of Sciences of the United States of America. 103: 7533-4. PMID 16682625 DOI: 10.1073/pnas.0602388103  1
2006 Brown AG, Leite RS, Engler AJ, Discher DE, Strauss JF. A hemoglobin fragment found in cervicovaginal fluid from women in labor potentiates the action of agents that promote contraction of smooth muscle cells. Peptides. 27: 1794-800. PMID 16621150 DOI: 10.1016/j.peptides.2006.03.015  1
2006 Subramanian S, Tsai R, Discher DE. The 'metabolon,' CD47, and the 'phagocytic synapse': molecular co-localization and species divergence. Transfusion Clinique Et Biologique : Journal De La SociéTé FrançAise De Transfusion Sanguine. 13: 31-8. PMID 16581280 DOI: 10.1016/j.tracli.2006.02.009  1
2006 Berry MF, Engler AJ, Woo YJ, Pirolli TJ, Bish LT, Jayasankar V, Morine KJ, Gardner TJ, Discher DE, Sweeney HL. Mesenchymal stem cell injection after myocardial infarction improves myocardial compliance. American Journal of Physiology. Heart and Circulatory Physiology. 290: H2196-203. PMID 16473959 DOI: 10.1152/ajpheart.01017.2005  1
2006 Subramanian S, Parthasarathy R, Sen S, Boder ET, Discher DE. Species- and cell type-specific interactions between CD47 and human SIRPalpha. Blood. 107: 2548-56. PMID 16291597 DOI: 10.1182/blood-2005-04-1463  1
2006 Parthasarathy R, Subramanian S, Boder ET, Discher DE. Post-translational regulation of expression and conformation of an immunoglobulin domain in yeast surface display. Biotechnology and Bioengineering. 93: 159-68. PMID 16161151 DOI: 10.1002/bit.20684  1
2006 Ahmed F, Photos PJ, Discher DE. Polymersomes as viral capsid mimics Drug Development Research. 67: 4-14. DOI: 10.1163/157006606775569622  1
2006 Geng Y, Discher DE. Visualization of degradable worm micelle breakdown in relation to drug release Polymer. 47: 2519-2525. DOI: 10.1016/j.polymer.2005.11.093  1
2006 Vijayan K, Discher DE. Block copolymer worm micelles in dilution: Mechanochemical metrics of robustness as a basis for novel linear assemblies Journal of Polymer Science, Part B: Polymer Physics. 44: 3431-3433. DOI: 10.1002/polb.21001  1
2006 Ortiz V, Nielsen SO, Klein ML, Discher DE. Computer simulation of aqueous block copolymer assemblies: Length scales and methods Journal of Polymer Science, Part B: Polymer Physics. 44: 1907-1918. DOI: 10.1002/polb.20836  1
2006 Qin S, Geng Y, Discher DE, Yang S. Temperature-controlled assembly and release from polymer vesicles of poly(ethylene oxide)-block-poly(N-isopropylacrylamide) Advanced Materials. 18: 2905-2909. DOI: 10.1002/adma.200601019  1
2006 Geng Y, Discher DE. Degradable poly(ethylene oxide)-block-polycaprolactone worm micelles Acs Symposium Series. 939: 168-182.  1
2005 Kim Y, Dalhaimer P, Christian DA, Discher DE. Polymeric worm micelles as nano-carriers for drug delivery. Nanotechnology. 16: S484-91. PMID 21727469 DOI: 10.1088/0957-4484/16/7/024  1
2005 Ortiz V, Nielsen SO, Discher DE, Klein ML, Lipowsky R, Shillcock J. Dissipative particle dynamics simulations of polymersomes. The Journal of Physical Chemistry. B. 109: 17708-14. PMID 16853266 DOI: 10.1021/jp0512762  1
2005 Vijayan K, Discher DE, Lal J, Janmey P, Goulian M. Interactions of membrane-active peptides with thick, neutral, nonzwitterionic bilayers. The Journal of Physical Chemistry. B. 109: 14356-64. PMID 16852806 DOI: 10.1021/jp050060x  1
2005 Geng Y, Ahmed F, Bhasin N, Discher DE. Visualizing worm micelle dynamics and phase transitions of a charged diblock copolymer in water. The Journal of Physical Chemistry. B. 109: 3772-9. PMID 16851424 DOI: 10.1021/jp0459559  1
2005 Srinivas G, Discher DE, Klein ML. Key roles for chain flexibility in block copolymer membranes that contain pores or make tubes. Nano Letters. 5: 2343-9. PMID 16351175 DOI: 10.1021/nl051515x  1
2005 Discher DE, Janmey P, Wang YL. Tissue cells feel and respond to the stiffness of their substrate. Science (New York, N.Y.). 310: 1139-43. PMID 16293750 DOI: 10.1126/science.1116995  1
2005 Geng Y, Discher DE. Hydrolytic degradation of poly(ethylene oxide)-block-polycaprolactone worm micelles. Journal of the American Chemical Society. 127: 12780-1. PMID 16159254 DOI: 10.1021/ja053902e  1
2005 Bhasin N, Law R, Liao G, Safer D, Ellmer J, Discher BM, Sweeney HL, Discher DE. Molecular extensibility of mini-dystrophins and a dystrophin rod construct. Journal of Molecular Biology. 352: 795-806. PMID 16139300 DOI: 10.1016/j.jmb.2005.07.064  1
2005 Sen S, Subramanian S, Discher DE. Indentation and adhesive probing of a cell membrane with AFM: theoretical model and experiments. Biophysical Journal. 89: 3203-13. PMID 16113121 DOI: 10.1529/biophysj.105.063826  1
2005 Dahl KN, Engler AJ, Pajerowski JD, Discher DE. Power-law rheology of isolated nuclei with deformation mapping of nuclear substructures. Biophysical Journal. 89: 2855-64. PMID 16055543 DOI: 10.1529/biophysj.105.062554  1
2005 Ortiz V, Nielsen SO, Klein ML, Discher DE. Unfolding a linker between helical repeats. Journal of Molecular Biology. 349: 638-47. PMID 15896349 DOI: 10.1016/j.jmb.2005.03.086  1
2005 Griffin MA, Feng H, Tewari M, Acosta P, Kawana M, Sweeney HL, Discher DE. gamma-Sarcoglycan deficiency increases cell contractility, apoptosis and MAPK pathway activation but does not affect adhesion. Journal of Cell Science. 118: 1405-16. PMID 15769854 DOI: 10.1242/jcs.01717  1
2005 Dalhaimer P, Wagner OI, Leterrier JF, Janmey PA, Aranda-Espinoza H, Discher DE. Flexibility transitions and looped adsorption of wormlike chains Journal of Polymer Science, Part B: Polymer Physics. 43: 280-286. DOI: 10.1002/polb.20332  1
2005 Subramanian S, Boder ET, Discher DE. Pleiotropic responses mediated by Cd47-Sirp□ binding: Adhesion as a common link Aiche Annual Meeting, Conference Proceedings. 8764.  1
2005 Ahmed F, Subramanian S, Tewari M, Discher DE. Targeting Cd47 as an apoptotic trigger of human lung carcinoma tumors Aiche Annual Meeting, Conference Proceedings. 9139.  1
2005 Engler AJ, Eckhardt A, Richert L, Picart C, Discher DE. Determining molecular length scales: Correlating cell spreading on nano-thin gels and films and tissue elasticity Proceedings of the 2005 Summer Bioengineering Conference. 2005: 471-472.  1
2005 Engler AJ, Berry MF, Sweeney HL, Discher DE. Substrate stiffness directs mesenchymal stem cell differentiation Proceedings of the 2005 Summer Bioengineering Conference. 2005: 311-312.  1
2005 Engler A, Discher DE. Substrate softness directs differentiation of human stem cells Aiche Annual Meeting, Conference Proceedings. 8828.  1
2005 Ahmed F, Srinivas G, Brannan A, Klein ML, Bates FS, Discher DE. Breaking down endolysosomal barriers for drug delivery with degradable polymersomes Aiche Annual Meeting, Conference Proceedings. 14294.  1
2005 Vijayan K, Discher DE. Electric field manipulation of charged cylindrical block copolymer micelles Aiche Annual Meeting, Conference Proceedings. 13944.  1
2005 Dalhaimer P, Geng Y, Photos PJ, Fyfe B, Tewari M, Discher DE. Long-circulating cylinder micelles demonstrate strong effects of morphology on biological transport Aiche Annual Meeting, Conference Proceedings. 14256.  1
2005 Ahmed F, Pakunlu RI, Srinivas G, Klein ML, Minko T, Discher DE. Degradable polymersomes that create new pathways for anti-cancer drugs Aiche Annual Meeting, Conference Proceedings. 14292.  1
2005 Ortiz V, Nielsen SO, Klein ML, Discher DE. Multiscale simulation studies on mechanisms of poration for hydrolytically degradable diblock copolymer membranes Aiche Annual Meeting, Conference Proceedings. 10686.  1
2004 Pata V, Ahmed F, Discher DE, Dant N. Membrane solubilization by detergent: resistance conferred by thickness. Langmuir : the Acs Journal of Surfaces and Colloids. 20: 3888-93. PMID 15969375 DOI: 10.1021/la035734e  1
2004 Bermúdez H, Hammer DA, Discher DE. Effect of bilayer thickness on membrane bending rigidity. Langmuir : the Acs Journal of Surfaces and Colloids. 20: 540-3. PMID 15773070 DOI: 10.1021/la035497f  1
2004 Griffin MA, Sen S, Sweeney HL, Discher DE. Adhesion-contractile balance in myocyte differentiation. Journal of Cell Science. 117: 5855-63. PMID 15522893 DOI: 10.1242/jcs.01496  1
2004 Janmey PA, Discher DE. Developmental biology: holding it together in the eye. Nature. 431: 635-6. PMID 15470408 DOI: 10.1038/431635a  1
2004 Engler AJ, Griffin MA, Sen S, Bönnemann CG, Sweeney HL, Discher DE. Myotubes differentiate optimally on substrates with tissue-like stiffness: pathological implications for soft or stiff microenvironments. The Journal of Cell Biology. 166: 877-87. PMID 15364962 DOI: 10.1083/jcb.200405004  1
2004 Richert L, Engler AJ, Discher DE, Picart C. Elasticity of native and cross-linked polyelectrolyte multilayer films. Biomacromolecules. 5: 1908-16. PMID 15360305 DOI: 10.1021/bm0498023  1
2004 Dalhaimer P, Engler AJ, Parthasarathy R, Discher DE. Targeted worm micelles. Biomacromolecules. 5: 1714-9. PMID 15360279 DOI: 10.1021/bm049884v  1
2004 Hategan A, Sengupta K, Kahn S, Sackmann E, Discher DE. Topographical pattern dynamics in passive adhesion of cell membranes Biophysical Journal. 87: 3547-3560. PMID 15339814 DOI: 10.1529/biophysj.104.041475  1
2004 Dahl KN, Kahn SM, Wilson KL, Discher DE. The nuclear envelope lamina network has elasticity and a compressibility limit suggestive of a molecular shock absorber. Journal of Cell Science. 117: 4779-86. PMID 15331638 DOI: 10.1242/jcs.01357  1
2004 Bhasin N, Carl P, Harper S, Feng G, Lu H, Speicher DW, Discher DE. Chemistry on a single protein, vascular cell adhesion molecule-1, during forced unfolding. The Journal of Biological Chemistry. 279: 45865-74. PMID 15308645 DOI: 10.1074/jbc.M404103200  1
2004 Srinivas G, Discher DE, Klein ML. Self-assembly and properties of diblock copolymers by coarse-grain molecular dynamics. Nature Materials. 3: 638-44. PMID 15300242 DOI: 10.1038/nmat1185  1
2004 Discher DE, Kamien RD. Towards precision micelles Nature. 430: 519-520. PMID 15282592 DOI: 10.1038/430519a  1
2004 Dogic Z, Zhang J, Lau AWC, Aranda-Espinoza H, Dalhaimer P, Discher DE, Janmey PA, Kamien RD, Lubensky TC, Yodh AG. Elongation and fluctuations of semiflexible polymers in a nematic solvent Physical Review Letters. 92: 125503-1. PMID 15089684 DOI: 10.1103/PhysRevLett.92.125503  1
2004 Ahmed F, Discher DE. Self-porating polymersomes of PEG-PLA and PEG-PCL: hydrolysis-triggered controlled release vesicles. Journal of Controlled Release : Official Journal of the Controlled Release Society. 96: 37-53. PMID 15063028 DOI: 10.1016/j.jconrel.2003.12.021  1
2004 Law R, Harper S, Speicher DW, Discher DE. Influence of lateral association on forced unfolding of antiparallel spectrin heterodimers. The Journal of Biological Chemistry. 279: 16410-6. PMID 14761982 DOI: 10.1074/jbc.M313107200  0.56
2004 Griffin MA, Engler AJ, Barber TA, Healy KE, Sweeney HL, Discher DE. Patterning, prestress, and peeling dynamics of myocytes. Biophysical Journal. 86: 1209-22. PMID 14747355 DOI: 10.1016/S0006-3495(04)74195-8  1
2004 Dahl KN, Parthasarathy R, Westhoff CM, Layton DM, Discher DE. Protein 4.2 is critical to CD47-membrane skeleton attachment in human red cells. Blood. 103: 1131-6. PMID 14551146 DOI: 10.1182/blood-2003-04-1331  1
2004 Srinivas G, Shelley JC, Nielsen SO, Discher DE, Klein ML. Simulation of diblock copolymer self-assembly, using a coarse-grain model Journal of Physical Chemistry B. 108: 8153-8160. DOI: 10.1021/jp037842f  1
2004 Engler AJ, Richert L, Wong JY, Picart C, Discher DE. Surface probe measurements of the elasticity of sectioned tissue, thin gels and polyelectrolyte multilayer films: Correlations between substrate stiffness and cell adhesion Surface Science. 570: 142-154. DOI: 10.1016/j.susc.2004.06.179  1
2003 Law R, Liao G, Harper S, Yang G, Speicher DW, Discher DE. Pathway shifts and thermal softening in temperature-coupled forced unfolding of spectrin domains. Biophysical Journal. 85: 3286-93. PMID 14581229 DOI: 10.1016/S0006-3495(03)74747-X  1
2003 Hategan A, Law R, Kahn S, Discher DE. Adhesively-tensed cell membranes: lysis kinetics and atomic force microscopy probing. Biophysical Journal. 85: 2746-59. PMID 14507737 DOI: 10.1016/S0006-3495(03)74697-9  1
2003 Photos PJ, Bacakova L, Discher B, Bates FS, Discher DE. Polymer vesicles in vivo: correlations with PEG molecular weight. Journal of Controlled Release : Official Journal of the Controlled Release Society. 90: 323-34. PMID 12880699 DOI: 10.1016/S0168-3659(03)00201-3  1
2003 Law R, Carl P, Harper S, Dalhaimer P, Speicher DW, Discher DE. Cooperativity in forced unfolding of tandem spectrin repeats. Biophysical Journal. 84: 533-44. PMID 12524305 DOI: 10.1016/S0006-3495(03)74872-3  1
2003 Dahl KN, Westhoff CM, Discher DE. Fractional attachment of CD47 (IAP) to the erythrocyte cytoskeleton and visual colocalization with Rh protein complexes. Blood. 101: 1194-9. PMID 12393442 DOI: 10.1182/blood-2002-04-1187  1
2002 Aranda-Espinoza H, Carl P, Leterrier JF, Janmey P, Discher DE. Domain unfolding in neurofilament sidearms: effects of phosphorylation and ATP. Febs Letters. 531: 397-401. PMID 12435582 DOI: 10.1016/S0014-5793(02)03515-9  1
2002 Discher DE, Eisenberg A. Polymer vesicles. Science (New York, N.Y.). 297: 967-73. PMID 12169723 DOI: 10.1126/science.1074972  1
2001 Aranda-Espinoza H, Bermudez H, Bates FS, Discher DE. Electromechanical limits of polymersomes. Physical Review Letters. 87: 208301. PMID 11690515  1
2001 Lee JC, Bermudez H, Discher BM, Sheehan MA, Won YY, Bates FS, Discher DE. Preparation, stability, and in vitro performance of vesicles made with diblock copolymers. Biotechnology and Bioengineering. 73: 135-45. PMID 11255161 DOI: 10.1002/bit.1045  1
2000 Picart C, Dalhaimer P, Discher DE. Actin protofilament orientation in deformation of the erythrocyte membrane skeleton. Biophysical Journal. 79: 2987-3000. PMID 11106606 DOI: 10.1016/S0006-3495(00)76535-0  0.64
1999 Picart C, Discher DE. Actin protofilament orientation at the erythrocyte membrane. Biophysical Journal. 77: 865-78. PMID 10423432 DOI: 10.1016/S0006-3495(99)76938-9  0.4
1999 Discher BM, Won YY, Ege DS, Lee JC, Bates FS, Discher DE, Hammer DA. Polymersomes: tough vesicles made from diblock copolymers. Science (New York, N.Y.). 284: 1143-6. PMID 10325219 DOI: 10.1126/science.284.5417.1143  1
1999 Ra HJ, Picart C, Feng H, Sweeney HL, Discher DE. Muscle cell peeling from micropatterned collagen: direct probing of focal and molecular properties of matrix adhesion. Journal of Cell Science. 112: 1425-36. PMID 10212137  1
1996 Discher DE, Mohandas N. Kinematics of red cell aspiration by fluorescence-imaged microdeformation. Biophysical Journal. 71: 1680-94. PMID 8889146 DOI: 10.1016/S0006-3495(96)79424-9  0.48
1995 Schischmanoff PO, Winardi R, Discher DE, Parra MK, Bicknese SE, Witkowska HE, Conboy JG, Mohandas N. Defining of the minimal domain of protein 4.1 involved in spectrin-actin binding. The Journal of Biological Chemistry. 270: 21243-50. PMID 7673158  0.48
1995 Discher DE, Winardi R, Schischmanoff PO, Parra M, Conboy JG, Mohandas N. Mechanochemistry of protein 4.1's spectrin-actin-binding domain: ternary complex interactions, membrane binding, network integration, structural strengthening. The Journal of Cell Biology. 130: 897-907. PMID 7642705  0.48
1994 Discher DE, Mohandas N, Evans EA. Molecular maps of red cell deformation: hidden elasticity and in situ connectivity. Science (New York, N.Y.). 266: 1032-5. PMID 7973655  1
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