Edgar Young, Ph.D. - Publications

Molecular Biology and Biochemistry Simon Fraser University, Burnaby, British Columbia, Canada 
biophysics of ion channels

18 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Magee KEA, Madden Z, Young EC. HCN Channel C-Terminal Region Speeds Activation Rates Independently of Autoinhibition Journal of Membrane Biology. DOI: 10.1007/s00232-015-9816-7  1
2013 Young EC. Will the real single HCN channel please stand up? Biophysical Journal. 105: 1549-50. PMID 24094395 DOI: 10.1016/j.bpj.2013.08.028  1
2013 Bovero E, Magee KEA, Young EC, Menon C. Dispersion of silver nanoparticles into polymer matrix dry adhesives to achieve antibacterial properties, increased adhesion, and optical absorption Macromolecular Reaction Engineering. 7: 624-631. DOI: 10.1002/mren.201300110  1
2011 Wong WF, Chan KS, Michaleski MS, Haesler A, Young EC. Ligand-binding domain subregions contributing to bimodal agonism in cyclic nucleotide-gated channels. The Journal of General Physiology. 137: 591-603. PMID 21624949 DOI: 10.1085/jgp.201010560  1
2011 Wicks NL, Wong T, Sun J, Madden Z, Young EC. Cytoplasmic cAMP-sensing domain of hyperpolarization-activated cation (HCN) channels uses two structurally distinct mechanisms to regulate voltage gating. Proceedings of the National Academy of Sciences of the United States of America. 108: 609-14. PMID 21187420 DOI: 10.1073/pnas.1012750108  1
2010 Young EC. Ion channels regulated by direct binding of cyclic nucleotides Handbook of Cell Signaling, 2/E. 1: 225-231. DOI: 10.1016/B978-0-12-374145-5.00034-6  1
2009 Chan KS, Young EC. Bimodal agonism in heteromeric cyclic nucleotide-gated channels. Channels (Austin, Tex.). 3: 427-36. PMID 19823021  1
2009 Wicks NL, Chan KS, Madden Z, Santoro B, Young EC. Sensitivity of HCN channel deactivation to cAMP is amplified by an S4 mutation combined with activation mode shift. PflüGers Archiv : European Journal of Physiology. 458: 877-89. PMID 19544068 DOI: 10.1007/s00424-009-0687-6  1
2004 Zhou L, Olivier NB, Yao H, Young EC, Siegelbaum SA. A conserved tripeptide in CNG and HCN channels regulates ligand gating by controlling C-terminal oligomerization. Neuron. 44: 823-34. PMID 15572113 DOI: 10.1016/j.neuron.2004.11.012  1
2004 Young EC, Krougliak N. Distinct structural determinants of efficacy and sensitivity in the ligand-binding domain of cyclic nucleotide-gated channels. The Journal of Biological Chemistry. 279: 3553-62. PMID 14594805 DOI: 10.1074/jbc.M310545200  1
2003 Zagotta WN, Olivier NB, Black KD, Young EC, Olson R, Gouaux E. Structural basis for modulation and agonist specificity of HCN pacemaker channels. Nature. 425: 200-5. PMID 12968185 DOI: 10.1038/nature01922  1
2001 Young EC, Sciubba DM, Siegelbaum SA. Efficient coupling of ligand binding to channel opening by the binding domain of a modulatory (beta) subunit of the olfactory cyclic nucleotide-gated channel. The Journal of General Physiology. 118: 523-46. PMID 11696610 DOI: 10.1085/jgp.118.5.523  1
1999 Paoletti P, Young EC, Siegelbaum SA. C-Linker of cyclic nucleotide-gated channels controls coupling of ligand binding to channel gating. The Journal of General Physiology. 113: 17-34. PMID 9874685 DOI: 10.1085/jgp.113.1.17  1
1998 Young EC, Mahtani HK, Gelles J. One-headed kinesin derivatives move by a nonprocessive, low-duty ratio mechanism unlike that of two-headed kinesin. Biochemistry. 37: 3467-79. PMID 9521668 DOI: 10.1021/bi972172n  0.88
1997 Hua W, Young EC, Fleming ML, Gelles J. Coupling of kinesin steps to ATP hydrolysis. Nature. 388: 390-3. PMID 9237758 DOI: 10.1038/41118  0.88
1995 Young EC, Berliner E, Mahtani HK, Perez-Ramirez B, Gelles J. Subunit interactions in dimeric kinesin heavy chain derivatives that lack the kinesin rod. The Journal of Biological Chemistry. 270: 3926-31. PMID 7876139 DOI: 10.1074/jbc.270.8.3926  0.88
1995 Berliner E, Young EC, Anderson K, Mahtani HK, Gelles J. Failure of a single-headed kinesin to track parallel to microtubule protofilaments. Nature. 373: 718-21. PMID 7854458 DOI: 10.1038/373718a0  0.88
1995 Gelles J, Berliner E, Young EC, Mahtani HK, Perez-Ramirez B, Anderson K. Structural and functional features of one- and two-headed biotinated kinesin derivatives. Biophysical Journal. 68: 276S-281S; discussio. PMID 7787090  0.88
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