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Kimberley A. Lentz, Ph.D. - Publications

Affiliations: 
2000 University of Maryland School of Medicine, Baltimore, MD, United States 
Area:
Pharmacy, Pharmaceutical Chemistry
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29 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Guarino VR, Olson RE, Everlof JG, Wang N, McDonald I, Haskell R, Clarke W, Lentz KA. An amide-based sulfenamide prodrug of gamma secretase inhibitor BMS-708163 delivers parent drug from an oral conventional solid dosage form in male beagle dog. Bioorganic & Medicinal Chemistry Letters. 126856. PMID 31870650 DOI: 10.1016/J.Bmcl.2019.126856  0.384
2019 Boy KM, Guernon JM, Zuev DS, Xu L, Zhang Y, Shi J, Marcin LR, Higgins MA, Wu YJ, Krishnananthan S, Li J, Trehan A, Smith D, Toyn JH, Meredith JE, ... ... Lentz KA, et al. Identification and Preclinical Evaluation of the Bicyclic Pyrimidine γ-Secretase Modulator BMS-932481. Acs Medicinal Chemistry Letters. 10: 312-317. PMID 30891132 DOI: 10.1021/Acsmedchemlett.8B00541  0.356
2018 Onorato JM, Xu C, Chen XQ, Rose AV, Generaux C, Lentz K, Shipkova P, Arthur S, Hennan JK, Haskell R, Myers MC, Lawrence RM, Finlay HJ, Basso M, Bostwick J, et al. Linking (Pyr)apelin-13 pharmacokinetics to efficacy: Stabilization and measurement of a high clearance peptide in rodents. Analytical Biochemistry. PMID 30605634 DOI: 10.1016/J.Ab.2018.12.022  0.329
2017 Narang AS, Balakrishnan A, Morrison J, Li J, Wang J, Gu H, Taylor K, Santone K, Ehrmann J, Beyer S, Lu X, Ketner R, Pizzano J, Orcutt T, Shields E, ... ... Lentz K, et al. Role of Regional Absorption and Gastrointestinal Motility on Variability in Oral Drug Absorption of a Model Drug. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V. PMID 28455207 DOI: 10.1016/J.Ejpb.2017.04.026  0.354
2017 Martinez MN, Mistry B, Lukacova V, Lentz KA, Polli JE, Hoag SW, Dowling T, Kona R, Fahmy RM. Exploring Canine-Human Differences in Product Performance. Part II: Use of Modeling and Simulation to Explore the Impact of Formulation on Ciprofloxacin In Vivo Absorption and Dissolution in Dogs. The Aaps Journal. PMID 28265981 DOI: 10.1208/S12248-017-0055-Y  0.537
2016 Soares HD, Gasior M, Toyn JH, Wang JS, Hong Q, Berisha F, Furlong MT, Raybon J, Lentz KA, Sweeney F, Zheng N, Akinsanya B, Berman RM, Thompson LA, Olson RE, et al. The Gamma Secretase Modulator, BMS-932481, Modulates Aβ Peptides in the Plasma and CSF of Healthy Volunteers. The Journal of Pharmacology and Experimental Therapeutics. PMID 27189973 DOI: 10.1124/Jpet.116.232256  0.311
2016 Ahuja VT, Hartz RA, Molski TF, Mattson GK, Lentz KA, Grace JE, Lodge NJ, Bronson JJ, Macor JE. Synthesis and evaluation of carbamate and aryl ether substituted pyrazinones as corticotropin releasing factor-1 (CRF1) receptor antagonists. Bioorganic & Medicinal Chemistry Letters. PMID 27020524 DOI: 10.1016/J.Bmcl.2016.03.067  0.318
2015 Boy KM, Guernon JM, Wu YJ, Zhang Y, Shi J, Zhai W, Zhu S, Gerritz SW, Toyn JH, Meredith JE, Barten DM, Burton CR, Albright CF, Good AC, Grace JE, ... Lentz KA, et al. Macrocyclic prolinyl acyl guanidines as inhibitors of β-secretase (BACE). Bioorganic & Medicinal Chemistry Letters. PMID 26497283 DOI: 10.1016/J.Bmcl.2015.10.031  0.336
2015 Baumgart BR, Van Vleet TR, Simic D, Salcedo TW, Lentz K, Donegan M, Davies MH, Bunch RT, Sanderson TP, Lange RW. D-α-tocopheryl polyethylene glycol 1000 succinate-containing vehicles provide no detectable chemoprotection from oxidative damage. Journal of Applied Toxicology : Jat. 35: 791-8. PMID 25348750 DOI: 10.1002/Jat.3072  0.328
2014 Toyn JH, Thompson LA, Lentz KA, Meredith JE, Burton CR, Sankaranararyanan S, Guss V, Hall T, Iben LG, Krause CM, Krause R, Lin XA, Pierdomenico M, Polson C, Robertson AS, et al. Identification and Preclinical Pharmacology of the γ-Secretase Modulator BMS-869780. International Journal of Alzheimer's Disease. 2014: 431858. PMID 25097793 DOI: 10.1155/2014/431858  0.354
2014 Hu S, Huang Y, Wu YJ, He H, Grant-Young KA, Bertekap RL, Whiterock V, Brassil P, Lentz K, Sivaprakasam P, Langley DR, Westphal RS, Scola PM. Structure activity relationship studies of 3-arylsulfonyl-pyrido[1,2-a]pyrimidin-4-imines as potent 5-HT₆ antagonists. Bioorganic & Medicinal Chemistry. 22: 1782-90. PMID 24495863 DOI: 10.1016/J.Bmc.2014.01.003  0.36
2013 Vivian D, Cheng K, Khurana S, Xu S, Whiterock V, Witter D, Lentz KA, Santone KS, Raufman JP, Polli JE. Design and characterization of a novel fluorinated magnetic resonance imaging agent for functional analysis of bile Acid transporter activity. Pharmaceutical Research. 30: 1240-51. PMID 23319170 DOI: 10.1007/S11095-012-0963-6  0.595
2013 Albright CF, Dockens RC, Meredith JE, Olson RE, Slemmon R, Lentz KA, Wang JS, Denton RR, Pilcher G, Rhyne PW, Raybon JJ, Barten DM, Burton C, Toyn JH, Sankaranarayanan S, et al. Pharmacodynamics of selective inhibition of γ-secretase by avagacestat. The Journal of Pharmacology and Experimental Therapeutics. 344: 686-95. PMID 23275065 DOI: 10.1124/Jpet.112.199356  0.33
2012 Luo G, Chen L, Conway CM, Denton R, Keavy D, Gulianello M, Huang Y, Kostich W, Lentz KA, Mercer SE, Schartman R, Signor L, Browning M, Macor JE, Dubowchik GM. Discovery of BMS-846372, a Potent and Orally Active Human CGRP Receptor Antagonist for the Treatment of Migraine. Acs Medicinal Chemistry Letters. 3: 337-41. PMID 24900474 DOI: 10.1021/Ml300021S  0.392
2012 Luo G, Chen L, Conway CM, Denton R, Keavy D, Signor L, Kostich W, Lentz KA, Santone KS, Schartman R, Browning M, Tong G, Houston JG, Dubowchik GM, Macor JE. Discovery of (5S,6S,9R)-5-amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate (BMS-927711): an oral calcitonin gene-related peptide (CGRP) antagonist in clinical trials for treating migraine. Journal of Medicinal Chemistry. 55: 10644-51. PMID 23153230 DOI: 10.1021/Jm3013147  0.349
2012 Gerritz SW, Zhai W, Shi S, Zhu S, Toyn JH, Meredith JE, Iben LG, Burton CR, Albright CF, Good AC, Tebben AJ, Muckelbauer JK, Camac DM, Metzler W, Cook LS, ... ... Lentz KA, et al. Acyl guanidine inhibitors of β-secretase (BACE-1): optimization of a micromolar hit to a nanomolar lead via iterative solid- and solution-phase library synthesis. Journal of Medicinal Chemistry. 55: 9208-23. PMID 23030502 DOI: 10.1021/Jm300931Y  0.335
2012 Whiterock VJ, Morgan DG, Lentz KA, Orcutt TL, Sinz MW. Phenacetin pharmacokinetics in CYP1A2-deficient beagle dogs Drug Metabolism and Disposition. 40: 228-231. PMID 22074769 DOI: 10.1124/Dmd.111.041848  0.308
2011 Thompson LA, Shi J, Decicco CP, Tebben AJ, Olson RE, Boy KM, Guernon JM, Good AC, Liauw A, Zheng C, Copeland RA, Combs AP, Trainor GL, Camac DM, Muckelbauer JK, ... Lentz KA, et al. Synthesis and in vivo evaluation of cyclic diaminopropane BACE-1 inhibitors. Bioorganic & Medicinal Chemistry Letters. 21: 6909-15. PMID 21974952 DOI: 10.1016/J.Bmcl.2011.06.116  0.342
2011 Boy KM, Guernon JM, Shi J, Toyn JH, Meredith JE, Barten DM, Burton CR, Albright CF, Marcinkeviciene J, Good AC, Tebben AJ, Muckelbauer JK, Camac DM, Lentz KA, Bronson JJ, et al. Monosubstituted γ-lactam and conformationally constrained 1,3-diaminopropan-2-ol transition-state isostere inhibitors of β-secretase (BACE). Bioorganic & Medicinal Chemistry Letters. 21: 6916-24. PMID 21782431 DOI: 10.1016/J.Bmcl.2011.06.109  0.332
2011 Marcin LR, Higgins MA, Zusi FC, Zhang Y, Dee MF, Parker MF, Muckelbauer JK, Camac DM, Morin PE, Ramamurthy V, Tebben AJ, Lentz KA, Grace JE, Marcinkeviciene JA, Kopcho LM, et al. Synthesis and SAR of indole-and 7-azaindole-1,3-dicarboxamide hydroxyethylamine inhibitors of BACE-1. Bioorganic & Medicinal Chemistry Letters. 21: 537-41. PMID 21078556 DOI: 10.1016/J.Bmcl.2010.10.079  0.363
2010 Gillman KW, Starrett JE, Parker MF, Xie K, Bronson JJ, Marcin LR, McElhone KE, Bergstrom CP, Mate RA, Williams R, Meredith JE, Burton CR, Barten DM, Toyn JH, Roberts SB, ... Lentz KA, et al. Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor. Acs Medicinal Chemistry Letters. 1: 120-4. PMID 24900185 DOI: 10.1021/Ml1000239  0.382
2009 Hartz RA, Ahuja VT, Zhuo X, Mattson RJ, Denhart DJ, Deskus JA, Vrudhula VM, Pan S, Ditta JL, Shu YZ, Grace JE, Lentz KA, Lelas S, Li YW, Molski TF, et al. A strategy to minimize reactive metabolite formation: discovery of (S)-4-(1-cyclopropyl-2-methoxyethyl)-6-[6-(difluoromethoxy)-2,5-dimethylpyridin-3-ylamino]-5-oxo-4,5-dihydropyrazine-2-carbonitrile as a potent, orally bioavailable corticotropin-releasing factor-1 receptor antagonist. Journal of Medicinal Chemistry. 52: 7653-68. PMID 19954247 DOI: 10.1021/Jm900716V  0.399
2009 Hartz RA, Ahuja VT, Arvanitis AG, Rafalski M, Yue EW, Denhart DJ, Schmitz WD, Ditta JL, Deskus JA, Brenner AB, Hobbs FW, Payne J, Lelas S, Li YW, Molski TF, ... ... Lentz KA, et al. Synthesis, structure-activity relationships, and in vivo evaluation of N3-phenylpyrazinones as novel corticotropin-releasing factor-1 (CRF1) receptor antagonists. Journal of Medicinal Chemistry. 52: 4173-91. PMID 19552437 DOI: 10.1021/Jm900301Y  0.356
2009 Hartz RA, Ahuja VT, Rafalski M, Schmitz WD, Brenner AB, Denhart DJ, Ditta JL, Deskus JA, Yue EW, Arvanitis AG, Lelas S, Li YW, Molski TF, Wong H, Grace JE, ... Lentz KA, et al. In vitro intrinsic clearance-based optimization of N3-phenylpyrazinones as corticotropin-releasing factor-1 (CRF1) receptor antagonists. Journal of Medicinal Chemistry. 52: 4161-72. PMID 19552436 DOI: 10.1021/Jm900302Q  0.361
2008 Lentz KA. Current methods for predicting human food effect. The Aaps Journal. 10: 282-8. PMID 18500565 DOI: 10.1208/S12248-008-9025-8  0.311
2008 Meredith JE, Thompson LA, Toyn JH, Marcin L, Barten DM, Marcinkeviciene J, Kopcho L, Kim Y, Lin A, Guss V, Burton C, Iben L, Polson C, Cantone J, Ford M, ... ... Lentz KA, et al. P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice. The Journal of Pharmacology and Experimental Therapeutics. 326: 502-13. PMID 18499745 DOI: 10.1124/Jpet.108.138974  0.313
2004 Tolle-Sander S, Lentz KA, Maeda DY, Coop A, Polli JE. Increased acyclovir oral bioavailability via a bile acid conjugate. Molecular Pharmaceutics. 1: 40-8. PMID 15832499 DOI: 10.1021/Mp034010T  0.565
2000 Lentz KA, Polli JW, Wring SA, Humphreys JE, Polli JE. Influence of passive permeability on apparent P-glycoprotein kinetics. Pharmaceutical Research. 17: 1456-60. PMID 11303953 DOI: 10.1023/A:1007692622216  0.472
2000 Lentz KA, Hayashi J, Lucisano LJ, Polli JE. Development of a more rapid, reduced serum culture system for Caco-2 monolayers and application to the biopharmaceutics classification system. International Journal of Pharmaceutics. 200: 41-51. PMID 10845684 DOI: 10.1016/S0378-5173(00)00334-3  0.482
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