Lewis C. Cantley, Ph.D. - Publications

Systems Biology Harvard University, Cambridge, MA, United States 
PI3K and cancer metabolism

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Year Citation  Score
2020 Ngo B, Kim E, Osorio-Vasquez V, Doll S, Bustraan S, Liang RJ, Luengo A, Davidson SM, Ali A, Ferraro GB, Fischer GM, Eskandari R, Kang DS, Ni J, Plasger A, ... ... Cantley LC, et al. Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition. Cancer Discovery. PMID 32571778 DOI: 10.1158/2159-8290.CD-19-1228  1
2020 Liu H, Paddock MN, Wang H, Murphy CJ, Geck RC, Navarro AJ, Wulf GM, Elemento O, Haucke V, Cantley LC, Toker A. The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple Negative Breast Cancer. Cancer Discovery. PMID 32513774 DOI: 10.1158/2159-8290.CD-19-1262  0.6
2020 Manz TD, Sivakumaren SC, Yasgar A, Hall MD, Davis MI, Seo HS, Card JD, Ficarro SB, Shim H, Marto JA, Dhe-Paganon S, Sasaki AT, Boxer MB, Simeonov A, Cantley LC, et al. Structure-Activity Relationship Study of Covalent Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors. Acs Medicinal Chemistry Letters. 11: 346-352. PMID 32184968 DOI: 10.1021/acsmedchemlett.9b00402  0.32
2020 Sivakumaren SC, Shim H, Zhang T, Ferguson FM, Lundquist MR, Browne CM, Seo HS, Paddock MN, Manz TD, Jiang B, Hao MF, Krishnan P, Wang DG, Yang TJ, Kwiatkowski NP, ... ... Cantley LC, et al. Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors. Cell Chemical Biology. PMID 32130941 DOI: 10.1016/j.chembiol.2020.02.003  0.6
2020 Nelson BS, Lin L, Kremer DM, Sousa CM, Cotta-Ramusino C, Myers A, Ramos J, Gao T, Kovalenko I, Wilder-Romans K, Dresser J, Davis M, Lee HJ, Nwosu ZC, Campit S, ... ... Cantley LC, et al. Tissue of origin dictates GOT1 dependence and confers synthetic lethality to radiotherapy. Cancer & Metabolism. 8: 1. PMID 31908776 DOI: 10.1186/s40170-019-0202-2  0.84
2019 Yoshida T, Yamasaki S, Kaneko O, Taoka N, Tomimoto Y, Namatame I, Yahata T, Kuromitsu S, Cantley LC, Lyssiotis CA. A covalent small molecule inhibitor of glutamate-oxaloacetate transaminase 1 impairs pancreatic cancer growth. Biochemical and Biophysical Research Communications. PMID 31787239 DOI: 10.1016/j.bbrc.2019.11.130  0.84
2019 Gomes AP, Ilter D, Low V, Rosenzweig A, Shen ZJ, Schild T, Rivas MA, Er EE, McNally DR, Mutvei AP, Han J, Ou YH, Cavaliere P, Mullarky E, Nagiec M, ... ... Cantley LC, et al. Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization. Cancer Cell. PMID 31564638 DOI: 10.1016/j.ccell.2019.08.006  0.8
2019 Nixon MJ, Formisano L, Mayer IA, Estrada MV, González-Ericsson PI, Isakoff SJ, Forero-Torres A, Won H, Sanders ME, Solit DB, Berger MF, Cantley LC, Winer EP, Arteaga CL, Balko JM. PIK3CA and MAP3K1 alterations imply luminal A status and are associated with clinical benefit from pan-PI3K inhibitor buparlisib and letrozole in ER+ metastatic breast cancer. Npj Breast Cancer. 5: 31. PMID 31552290 DOI: 10.1038/s41523-019-0126-6  0.4
2019 Mullarky E, Xu J, Robin AD, Huggins DJ, Jennings A, Noguchi N, Olland A, Lakshminarasimhan D, Miller M, Tomita D, Michino M, Su T, Zhang G, Stamford AW, Meinke PT, ... ... Cantley LC, et al. Inhibition of 3-phosphoglycerate dehydrogenase (PHGDH) by indole amides abrogates de novo serine synthesis in cancer cells. Bioorganic & Medicinal Chemistry Letters. PMID 31327531 DOI: 10.1016/j.bmcl.2019.07.011  0.8
2019 Li M, Chiang YL, Lyssiotis CA, Teater MR, Hong JY, Shen H, Wang L, Hu J, Jing H, Chen Z, Jain N, Duy C, Mistry SJ, Cerchietti L, Cross JR, ... Cantley LC, et al. Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis. Cancer Cell. 35: 916-931.e9. PMID 31185214 DOI: 10.1016/j.ccell.2019.05.002  0.84
2019 Wang DG, Paddock MN, Lundquist MR, Sun JY, Mashadova O, Amadiume S, Bumpus TW, Hodakoski C, Hopkins BD, Fine M, Hill A, Yang TJ, Baskin JM, Dow LE, Cantley LC. PIP4Ks Suppress Insulin Signaling through a Catalytic-Independent Mechanism. Cell Reports. 27: 1991-2001.e5. PMID 31091439 DOI: 10.1016/j.celrep.2019.04.070  0.6
2019 Ngo B, Van Riper JM, Cantley LC, Yun J. Targeting cancer vulnerabilities with high-dose vitamin C. Nature Reviews. Cancer. PMID 30967651 DOI: 10.1038/s41568-019-0135-7  1
2019 Goncalves MD, Lu C, Tutnauer J, Hartman TE, Hwang SK, Murphy CJ, Pauli C, Morris R, Taylor S, Bosch K, Yang S, Wang Y, Van Riper J, Lekaye HC, Roper J, ... ... Cantley LC, et al. High-fructose corn syrup enhances intestinal tumor growth in mice. Science (New York, N.Y.). 363: 1345-1349. PMID 30898933 DOI: 10.1126/science.aat8515  1
2019 Zheng Y, Ramsamooj S, Li Q, Johnson JL, Yaron TM, Sharra K, Cantley LC. Regulation of folate and methionine metabolism by multisite phosphorylation of human methylenetetrahydrofolate reductase. Scientific Reports. 9: 4190. PMID 30862944 DOI: 10.1038/s41598-019-40950-7  0.36
2019 Paddock MN, Field SJ, Cantley LC. Treating cancer with phosphatidylinositol-3-kinase inhibitors: increasing efficacy and overcoming resistance. Journal of Lipid Research. PMID 30718284 DOI: 10.1194/jlr.S092130  0.68
2018 Zheng Y, Cantley LC. Toward a better understanding of folate metabolism in health and disease. The Journal of Experimental Medicine. PMID 30587505 DOI: 10.1084/jem.20181965  0.36
2018 Zheng Y, Lin TY, Lee G, Paddock MN, Momb J, Cheng Z, Li Q, Fei DL, Stein BD, Ramsamooj S, Zhang G, Blenis J, Cantley LC. Mitochondrial One-Carbon Pathway Supports Cytosolic Folate Integrity in Cancer Cells. Cell. 175: 1546-1560.e17. PMID 30500537 DOI: 10.1016/j.cell.2018.09.041  0.6
2018 Holt MC, Assar Z, Beheshti Zavareh R, Lin L, Anglin J, Mashadova O, Haldar D, Mullarky E, Kremer DM, Cantley LC, Kimmelman AC, Stein AJ, Lairson LL, Lyssiotis CA. Biochemical Characterization and Structure-based Mutational Analysis Provides Insight into Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors. Biochemistry. PMID 30365304 DOI: 10.1021/acs.biochem.8b00914  0.84
2018 Anglin J, Zavareh RB, Sander PN, Haldar D, Mullarky E, Cantley LC, Kimmelman AC, Lyssiotis CA, Lairson LL. Discovery and optimization of aspartate aminotransferase 1 inhibitors to target redox balance in pancreatic ductal adenocarcinoma. Bioorganic & Medicinal Chemistry Letters. PMID 29731362 DOI: 10.1016/j.bmcl.2018.04.061  0.84
2018 Lundquist MR, Goncalves MD, Loughran RM, Possik E, Vijayaraghavan T, Yang A, Pauli C, Ravi A, Verma A, Yang Z, Johnson JL, Wong JCY, Ma Y, Hwang KS, Weinkove D, ... ... Cantley LC, et al. Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy. Molecular Cell. 70: 531-544.e9. PMID 29727621 DOI: 10.1016/j.molcel.2018.03.037  0.48
2018 Bakhoum SF, Ngo B, Laughney AM, Cavallo JA, Murphy CJ, Ly P, Shah P, Sriram RK, Watkins TBK, Taunk NK, Duran M, Pauli C, Shaw C, Chadalavada K, Rajasekhar VK, ... ... Cantley LC, et al. Chromosomal instability drives metastasis through a cytosolic DNA response. Nature. PMID 29342134 DOI: 10.1038/nature25432  1
2017 Liu H, Murphy CJ, Karreth FA, Emdal KB, White FM, Elemento O, Toker A, Wulf GM, Cantley LC. Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple Negative Breast Cancer. Cancer Discovery. PMID 29203461 DOI: 10.1158/2159-8290.CD-17-0679  0.48
2017 Lee G, Zheng Y, Cho S, Jang C, England C, Dempsey JM, Yu Y, Liu X, He L, Cavaliere PM, Chavez A, Zhang E, Isik M, Couvillon A, Dephoure NE, ... ... Cantley LC, et al. Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling. Cell. PMID 29153836 DOI: 10.1016/j.cell.2017.10.037  0.36
2017 Shukla SK, Purohit V, Mehla K, Gunda V, Chaika NV, Vernucci E, King RJ, Abrego J, Goode GD, Dasgupta A, Illies AL, Gebregiworgis T, Dai B, Augustine JJ, Murthy D, ... ... Cantley LC, et al. MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer. Cancer Cell. 32: 392. PMID 28898700 DOI: 10.1016/j.ccell.2017.08.008  0.84
2017 Fruman DA, Chiu H, Hopkins BD, Bagrodia S, Cantley LC, Abraham RT. The PI3K Pathway in Human Disease. Cell. 170: 605-635. PMID 28802037 DOI: 10.1016/j.cell.2017.07.029  0.32
2017 Lee HJ, Jedrychowski MP, Vinayagam A, Wu N, Shyh-Chang N, Hu Y, Min-Wen C, Moore JK, Asara JM, Lyssiotis CA, Perrimon N, Gygi SP, Cantley LC, Kirschner MW. Proteomic and Metabolomic Characterization of a Mammalian Cellular Transition from Quiescence to Proliferation. Cell Reports. 20: 721-736. PMID 28723573 DOI: 10.1016/j.celrep.2017.06.074  0.84
2017 Shukla SK, Purohit V, Mehla K, Gunda V, Chaika NV, Vernucci E, King RJ, Abrego J, Goode GD, Dasgupta A, Illies AL, Gebregiworgis T, Dai B, Augustine JJ, Murthy D, ... ... Cantley LC, et al. MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer. Cancer Cell. 32: 71-87.e7. PMID 28697344 DOI: 10.1016/j.ccell.2017.06.004  0.84
2017 Waldhart AN, Dykstra H, Peck AS, Boguslawski EA, Madaj ZB, Wen J, Veldkamp K, Hollowell M, Zheng B, Cantley LC, McGraw TE, Wu N. Phosphorylation of TXNIP by AKT Mediates Acute Influx of Glucose in Response to Insulin. Cell Reports. 19: 2005-2013. PMID 28591573 DOI: 10.1016/j.celrep.2017.05.041  0.36
2017 Zheng Y, Cantley LC. Membrane Lipids Speak to Histones. Molecular Cell. 66: 163-164. PMID 28431227 DOI: 10.1016/j.molcel.2017.04.001  0.36
2017 Ueki K, Fruman DA, Yballe CM, Fasshauer M, Klein J, Asano T, Cantley LC, Kahn CR. Positive and negative roles of p85α and p85β regulatory subunits of phosphoinositide 3-kinase in insulin signaling. The Journal of Biological Chemistry. 292: 5608. PMID 28363934 DOI: 10.1074/jbc.A117.305602  0.32
2017 Gupta A, Anjomani-Virmouni S, Koundouros N, Dimitriadi M, Choo-Wing R, Valle A, Zheng Y, Chiu YH, Agnihotri S, Zadeh G, Asara JM, Anastasiou D, Arends MJ, Cantley LC, Poulogiannis G. PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation. Molecular Cell. 65: 999-1013.e7. PMID 28306514 DOI: 10.1016/j.molcel.2017.02.019  0.48
2017 Patnaik A, Swanson KD, Csizmadia E, Solanki A, Landon-Brace N, Gehring MP, Helenius K, Olson BM, Pyzer AR, Wang LC, Elemento O, Novak J, Thornley TB, Asara JM, Montaser L, ... ... Cantley LC, et al. Cabozantinib Eradicates Advanced Murine Prostate Cancer by Activating Anti-Tumor Innate Immunity. Cancer Discovery. PMID 28274958 DOI: 10.1158/2159-8290.CD-16-0778  0.48
2017 Mathur D, Stratikopoulos E, Ozturk S, Steinbach N, Pegno S, Schoenfeld S, Yong R, Murty VV, Asara JM, Cantley LC, Parsons R. PTEN Regulates Glutamine Flux to Pyrimidine Synthesis and Sensitivity to Dihydroorotate Dehydrogenase Inhibition. Cancer Discovery. PMID 28255082 DOI: 10.1158/2159-8290.CD-16-0612  0.48
2017 Trousil S, Chen S, Mu C, Shaw FM, Yao Z, Ran Y, Shakuntala T, Merghoub T, Manstein D, Rosen N, Cantley LC, Zippin JH, Zheng B. Phenformin enhances the efficacy of ERK inhibition in NF1-mutant melanoma. The Journal of Investigative Dermatology. PMID 28143781 DOI: 10.1016/j.jid.2017.01.013  0.32
2017 Ravez S, Corbet C, Spillier Q, Dutu A, Robin AD, Mullarky E, Cantley LC, Feron O, Frédérick R. α-Ketothioamide derivatives: a promising tool to interrogate the phosphoglycerate dehydrogenase (PHGDH). Journal of Medicinal Chemistry. PMID 28085281 DOI: 10.1021/acs.jmedchem.6b01166  0.8
2016 Sousa CM, Biancur DE, Wang X, Halbrook CJ, Sherman MH, Zhang L, Kremer D, Hwang RF, Witkiewicz AK, Ying H, Asara JM, Evans RM, Cantley LC, Lyssiotis CA, Kimmelman AC. Erratum: Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion. Nature. PMID 27706144 DOI: 10.1038/nature19851  0.84
2016 Mullarky E, Lairson LL, Cantley LC, Lyssiotis CA. A novel small-molecule inhibitor of 3-phosphoglycerate dehydrogenase. Molecular & Cellular Oncology. 3: e1164280. PMID 27652319 DOI: 10.1080/23723556.2016.1164280  0.84
2016 Lien EC, Lyssiotis CA, Cantley LC. Metabolic Reprogramming by the PI3K-Akt-mTOR Pathway in Cancer. Recent Results in Cancer Research. Fortschritte Der Krebsforschung. ProgrèS Dans Les Recherches Sur Le Cancer. 207: 39-72. PMID 27557534 DOI: 10.1007/978-3-319-42118-6_3  1
2016 Sousa CM, Biancur DE, Wang X, Halbrook CJ, Sherman MH, Zhang L, Kremer D, Hwang RF, Witkiewicz AK, Ying H, Asara JM, Evans RM, Cantley LC, Lyssiotis CA, Kimmelman AC. Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion. Nature. PMID 27509858 DOI: 10.1038/nature19084  0.84
2016 Juvekar A, Hu H, Yadegarynia S, Lyssiotis CA, Ullas S, Lien EC, Bellinger G, Son J, Hok RC, Seth P, Daly MB, Kim B, Scully R, Asara JM, Cantley LC, et al. Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletion. Proceedings of the National Academy of Sciences of the United States of America. PMID 27402769 DOI: 10.1073/pnas.1522223113  1
2016 Shim H, Wu C, Ramsamooj S, Bosch KN, Chen Z, Emerling BM, Yun J, Liu H, Choo-Wing R, Yang Z, Wulf GM, Kuchroo VK, Cantley LC. Deletion of the gene Pip4k2c, a novel phosphatidylinositol kinase, results in hyperactivation of the immune system. Proceedings of the National Academy of Sciences of the United States of America. PMID 27313209 DOI: 10.1073/pnas.1600934113  1
2016 Lien EC, Lyssiotis CA, Juvekar A, Hu H, Asara JM, Cantley LC, Toker A. Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer. Nature Cell Biology. PMID 27088857 DOI: 10.1038/ncb3341  0.52
2016 DeNicola GM, Chen PH, Mullarky E, Sudderth JA, Hu Z, Wu D, Tang H, Xie Y, Asara JM, Huffman KE, Wistuba II, Minna JD, DeBerardinis RJ, Cantley LC. Erratum: NRF2 regulates serine biosynthesis in non-small cell lung cancer. Nature Genetics. 48: 473. PMID 27023779 DOI: 10.1038/ng0329-473a  0.84
2016 Breitkopf SB, Yang X, Begley MJ, Kulkarni M, Chiu YH, Turke AB, Lauriol J, Yuan M, Qi J, Engelman JA, Hong P, Kontaridis MI, Cantley LC, Perrimon N, Asara JM. A Cross-Species Study of PI3K Protein-Protein Interactions Reveals the Direct Interaction of P85 and SHP2. Scientific Reports. 6: 20471. PMID 26839216 DOI: 10.1038/srep20471  0.52
2016 Mullarky E, Lucki NC, Beheshti Zavareh R, Anglin JL, Gomes AP, Nicolay BN, Wong JC, Christen S, Takahashi H, Singh PK, Blenis J, Warren JD, Fendt SM, Asara JM, DeNicola GM, ... ... Cantley LC, et al. Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers. Proceedings of the National Academy of Sciences of the United States of America. PMID 26831078 DOI: 10.1073/pnas.1521548113  1
2016 Hu H, Juvekar A, Lyssiotis CA, Lien EC, Albeck JG, Oh D, Varma G, Hung YP, Ullas S, Lauring J, Seth P, Lundquist MR, Tolan DR, Grant AK, Needleman DJ, ... ... Cantley LC, et al. Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton. Cell. 164: 433-446. PMID 26824656 DOI: 10.1016/j.cell.2015.12.042  0.52
2015 DeNicola GM, Cantley LC. Cancer's Fuel Choice: New Flavors for a Picky Eater. Molecular Cell. 60: 514-23. PMID 26590711 DOI: 10.1016/j.molcel.2015.10.018  1
2015 Begley MJ, Yun CH, Gewinner CA, Asara JM, Johnson JL, Coyle AJ, Eck MJ, Apostolou I, Cantley LC. EGF-receptor specificity for phosphotyrosine-primed substrates provides signal integration with Src. Nature Structural & Molecular Biology. PMID 26551075 DOI: 10.1038/nsmb.3117  0.52
2015 Yun J, Mullarky E, Lu C, Bosch KN, Kavalier A, Rivera K, Roper J, Chio II, Giannopoulou EG, Rago C, Muley A, Asara JM, Paik J, Elemento O, Chen Z, ... ... Cantley LC, et al. Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH. Science (New York, N.Y.). PMID 26541605 DOI: 10.1126/science.aaa5004  1
2015 DeNicola GM, Chen PH, Mullarky E, Sudderth JA, Hu Z, Wu D, Tang H, Xie Y, Asara JM, Huffman KE, Wistuba II, Minna JD, DeBerardinis RJ, Cantley LC. NRF2 regulates serine biosynthesis in non-small cell lung cancer. Nature Genetics. PMID 26482881 DOI: 10.1038/ng.3421  0.52
2015 Chakrabarti G, Moore ZR, Luo X, Ilcheva M, Ali A, Padanad M, Zhou Y, Xie Y, Burma S, Scaglioni PP, Cantley LC, DeBerardinis RJ, Kimmelman AC, Lyssiotis CA, Boothman DA. Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachone. Cancer & Metabolism. 3: 12. PMID 26462257 DOI: 10.1186/s40170-015-0137-1  0.84
2015 Sadanandam A, Wullschleger S, Lyssiotis CA, Grotzinger C, Barbi S, Bersani S, Korner J, Wafy I, Mafficini A, Lawlor RT, Simbolo M, Asara JM, Blaker H, Cantley LC, Wiedenmann B, et al. A cross-species analysis in pancreatic neuroendocrine tumors reveals molecular subtypes with distinctive clinical, metastatic, developmental, and metabolic characteristics. Cancer Discovery. PMID 26446169 DOI: 10.1158/2159-8290.CD-15-0068  0.84
2015 Liu P, Gan W, Chin YR, Ogura K, Guo J, Zhang J, Wang B, Blenis J, Cantley LC, Toker A, Su B, Wei W. PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex. Cancer Discovery. 5: 1194-209. PMID 26293922 DOI: 10.1158/2159-8290.CD-15-0460  0.8
2015 Douris N, Melman T, Pecherer JM, Pissios P, Flier JS, Cantley LC, Locasale JW, Maratos-Flier E. Adaptive changes in amino acid metabolism permit normal longevity in mice consuming a low-carbohydrate ketogenic diet. Biochimica Et Biophysica Acta. 1852: 2056-65. PMID 26170063 DOI: 10.1016/j.bbadis.2015.07.009  0.8
2015 Dibble CC, Cantley LC. Regulation of mTORC1 by PI3K signaling. Trends in Cell Biology. 25: 545-55. PMID 26159692 DOI: 10.1016/j.tcb.2015.06.002  0.8
2015 Westin SN, Ju Z, Broaddus RR, Krakstad C, Li J, Pal N, Lu KH, Coleman RL, Hennessy BT, Klempner SJ, Werner HM, Salvesen HB, Cantley LC, Mills GB, Myers AP. PTEN loss is a context-dependent outcome determinant in obese and non-obese endometrioid endometrial cancer patients. Molecular Oncology. PMID 26045339 DOI: 10.1016/j.molonc.2015.04.014  1
2015 Ehrenberger T, Cantley LC, Yaffe MB. Computational prediction of protein-protein interactions. Methods in Molecular Biology (Clifton, N.J.). 1278: 57-75. PMID 25859943 DOI: 10.1007/978-1-4939-2425-7_4  0.52
2015 Wei S, Kozono S, Kats L, Nechama M, Li W, Guarnerio J, Luo M, You MH, Yao Y, Kondo A, Hu H, Bozkurt G, Moerke NJ, Cao S, Reschke M, ... ... Cantley LC, et al. Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer. Nature Medicine. 21: 457-66. PMID 25849135 DOI: 10.1038/nm.3839  1
2015 Chen J, Lee HJ, Wu X, Huo L, Kim SJ, Xu L, Wang Y, He J, Bollu LR, Gao G, Su F, Briggs J, Liu X, Melman T, Asara JM, ... ... Cantley LC, et al. Gain of glucose-independent growth upon metastasis of breast cancer cells to the brain. Cancer Research. 75: 554-65. PMID 25511375 DOI: 10.1158/0008-5472.CAN-14-2268  0.8
2015 Dibble CC, Cantley LC. Regulation of mTORC1 by PI3K signaling Trends in Cell Biology. DOI: 10.1016/j.tcb.2015.06.002  1
2014 Lyssiotis CA, Cantley LC. Acetate fuels the cancer engine. Cell. 159: 1492-4. PMID 25525870 DOI: 10.1016/j.cell.2014.12.009  1
2014 Thorner J, Hunter T, Cantley LC, Sever R. Signal transduction: From the atomic age to the post-genomic era. Cold Spring Harbor Perspectives in Biology. 6: a022913. PMID 25359498 DOI: 10.1101/cshperspect.a022913  1
2014 Wang YH, Israelsen WJ, Lee D, Yu VW, Jeanson NT, Clish CB, Cantley LC, Vander Heiden MG, Scadden DT. Cell-state-specific metabolic dependency in hematopoiesis and leukemogenesis. Cell. 158: 1309-23. PMID 25215489 DOI: 10.1016/j.cell.2014.07.048  1
2014 Viale A, Pettazzoni P, Lyssiotis CA, Ying H, Sánchez N, Marchesini M, Carugo A, Green T, Seth S, Giuliani V, Kost-Alimova M, Muller F, Colla S, Nezi L, Genovese G, ... ... Cantley LC, et al. Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function. Nature. 514: 628-32. PMID 25119024 DOI: 10.1038/nature13611  1
2014 González-Billalabeitia E, Seitzer N, Song SJ, Song MS, Patnaik A, Liu XS, Epping MT, Papa A, Hobbs RM, Chen M, Lunardi A, Ng C, Webster KA, Signoretti S, Loda M, ... ... Cantley LC, et al. Vulnerabilities of PTEN-TP53-deficient prostate cancers to compound PARP-PI3K inhibition. Cancer Discovery. 4: 896-904. PMID 24866151 DOI: 10.1158/2159-8290.CD-13-0230  1
2014 Park SW, Herrema H, Salazar M, Cakir I, Cabi S, Basibuyuk Sahin F, Chiu YH, Cantley LC, Ozcan U. BRD7 regulates XBP1s' activity and glucose homeostasis through its interaction with the regulatory subunits of PI3K. Cell Metabolism. 20: 73-84. PMID 24836559 DOI: 10.1016/j.cmet.2014.04.006  1
2014 Liu P, Begley M, Michowski W, Inuzuka H, Ginzberg M, Gao D, Tsou P, Gan W, Papa A, Kim BM, Wan L, Singh A, Zhai B, Yuan M, Wang Z, ... ... Cantley L, et al. Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus. Nature. 508: 541-5. PMID 24670654 DOI: 10.1038/nature13079  1
2014 Mayer IA, Abramson VG, Isakoff SJ, Forero A, Balko JM, Kuba MG, Sanders ME, Yap JT, Van den Abbeele AD, Li Y, Cantley LC, Winer E, Arteaga CL. Stand up to cancer phase Ib study of pan-phosphoinositide-3-kinase inhibitor buparlisib with letrozole in estrogen receptor-positive/human epidermal growth factor receptor 2-negative metastatic breast cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 32: 1202-9. PMID 24663045 DOI: 10.1200/JCO.2013.54.0518  1
2014 Chiu YH, Lee JY, Cantley LC. BRD7, a tumor suppressor, interacts with p85α and regulates PI3K activity. Molecular Cell. 54: 193-202. PMID 24657164 DOI: 10.1016/j.molcel.2014.02.016  1
2014 Dasgupta T, Croll DH, Owen JA, Vander Heiden MG, Locasale JW, Alon U, Cantley LC, Gunawardena J. A fundamental trade-off in covalent switching and its circumvention by enzyme bifunctionality in glucose homeostasis. The Journal of Biological Chemistry. 289: 13010-25. PMID 24634222 DOI: 10.1074/jbc.M113.546515  1
2014 Fruman DA, Cantley LC. Idelalisib--a PI3Kδ inhibitor for B-cell cancers. The New England Journal of Medicine. 370: 1061-2. PMID 24620870 DOI: 10.1056/NEJMe1400055  1
2014 Menon S, Dibble CC, Talbott G, Hoxhaj G, Valvezan AJ, Takahashi H, Cantley LC, Manning BD. Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome. Cell. 156: 771-85. PMID 24529379 DOI: 10.1016/j.cell.2013.11.049  1
2014 Cantley LC. Cancer, metabolism, fructose, artificial sweeteners, and going cold turkey on sugar. Bmc Biology. 12: 8. PMID 24484968 DOI: 10.1186/1741-7007-12-8  1
2014 Cheng H, Liu P, Zhang F, Xu E, Symonds L, Ohlson CE, Bronson RT, Maira SM, Di Tomaso E, Li J, Myers AP, Cantley LC, Mills GB, Zhao JJ. A genetic mouse model of invasive endometrial cancer driven by concurrent loss of Pten and Lkb1 Is highly responsive to mTOR inhibition. Cancer Research. 74: 15-23. PMID 24322983 DOI: 10.1158/0008-5472.CAN-13-0544  1
2014 Lyssiotis CA, Cantley LC. Targeting metabolic scavenging in pancreatic cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 6-8. PMID 24166909 DOI: 10.1158/1078-0432.CCR-13-2570  1
2013 Klempner SJ, Myers AP, Cantley LC. What a tangled web we weave: emerging resistance mechanisms to inhibition of the phosphoinositide 3-kinase pathway. Cancer Discovery. 3: 1345-54. PMID 24265156 DOI: 10.1158/2159-8290.CD-13-0063  1
2013 Emerling BM, Hurov JB, Poulogiannis G, Tsukazawa KS, Choo-Wing R, Wulf GM, Bell EL, Shim HS, Lamia KA, Rameh LE, Bellinger G, Sasaki AT, Asara JM, Yuan X, Bullock A, ... ... Cantley LC, et al. Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors. Cell. 155: 844-57. PMID 24209622 DOI: 10.1016/j.cell.2013.09.057  1
2013 Shyh-Chang N, Zhu H, Yvanka de Soysa T, Shinoda G, Seligson MT, Tsanov KM, Nguyen L, Asara JM, Cantley LC, Daley GQ. Lin28 enhances tissue repair by reprogramming cellular metabolism. Cell. 155: 778-92. PMID 24209617 DOI: 10.1016/j.cell.2013.09.059  1
2013 Yuan P, Ito K, Perez-Lorenzo R, Del Guzzo C, Lee JH, Shen CH, Bosenberg MW, McMahon M, Cantley LC, Zheng B. Phenformin enhances the therapeutic benefit of BRAF(V600E) inhibition in melanoma. Proceedings of the National Academy of Sciences of the United States of America. 110: 18226-31. PMID 24145418 DOI: 10.1073/pnas.1317577110  1
2013 Israelsen WJ, Dayton TL, Davidson SM, Fiske BP, Hosios AM, Bellinger G, Li J, Yu Y, Sasaki M, Horner JW, Burga LN, Xie J, Jurczak MJ, DePinho RA, Clish CB, ... ... Cantley LC, et al. PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells. Cell. 155: 397-409. PMID 24120138 DOI: 10.1016/j.cell.2013.09.025  1
2013 Lyssiotis CA, Cantley LC. Metabolic syndrome: F stands for fructose and fat. Nature. 502: 181-2. PMID 24108049 DOI: 10.1038/502181a  1
2013 Shen CH, Yuan P, Perez-Lorenzo R, Zhang Y, Lee SX, Ou Y, Asara JM, Cantley LC, Zheng B. Phosphorylation of BRAF by AMPK impairs BRAF-KSR1 association and cell proliferation. Molecular Cell. 52: 161-72. PMID 24095280 DOI: 10.1016/j.molcel.2013.08.044  1
2013 Yeo H, Lyssiotis CA, Zhang Y, Ying H, Asara JM, Cantley LC, Paik JH. FoxO3 coordinates metabolic pathways to maintain redox balance in neural stem cells. The Embo Journal. 32: 2589-602. PMID 24013118 DOI: 10.1038/emboj.2013.186  1
2013 Song SJ, Poliseno L, Song MS, Ala U, Webster K, Ng C, Beringer G, Brikbak NJ, Yuan X, Cantley LC, Richardson AL, Pandolfi PP. MicroRNA-antagonism regulates breast cancer stemness and metastasis via TET-family-dependent chromatin remodeling. Cell. 154: 311-24. PMID 23830207 DOI: 10.1016/j.cell.2013.06.026  1
2013 Lyssiotis CA, Son J, Cantley LC, Kimmelman AC. Pancreatic cancers rely on a novel glutamine metabolism pathway to maintain redox balance. Cell Cycle (Georgetown, Tex.). 12: 1987-8. PMID 23759579 DOI: 10.4161/cc.25307  1
2013 Lunardi A, Ala U, Epping MT, Salmena L, Clohessy JG, Webster KA, Wang G, Mazzucchelli R, Bianconi M, Stack EC, Lis R, Patnaik A, Cantley LC, Bubley G, Cordon-Cardo C, et al. A co-clinical approach identifies mechanisms and potential therapies for androgen deprivation resistance in prostate cancer. Nature Genetics. 45: 747-55. PMID 23727860 DOI: 10.1038/ng.2650  1
2013 Chen S, Jiang X, Gewinner CA, Asara JM, Simon NI, Cai C, Cantley LC, Balk SP. Tyrosine kinase BMX phosphorylates phosphotyrosine-primed motif mediating the activation of multiple receptor tyrosine kinases. Science Signaling. 6: ra40. PMID 23716717 DOI: 10.1126/scisignal.2003936  1
2013 Shyh-Chang N, Daley GQ, Cantley LC. Stem cell metabolism in tissue development and aging. Development (Cambridge, England). 140: 2535-47. PMID 23715547 DOI: 10.1242/dev.091777  1
2013 Liu Y, Marks K, Cowley GS, Carretero J, Liu Q, Nieland TJ, Xu C, Cohoon TJ, Gao P, Zhang Y, Chen Z, Altabef AB, Tchaicha JH, Wang X, Choe S, ... ... Cantley LC, et al. Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1-mutant lung cancer. Cancer Discovery. 3: 870-9. PMID 23715154 DOI: 10.1158/2159-8290.CD-13-0015  1
2013 Fendt SM, Bell EL, Keibler MA, Davidson SM, Wirth GJ, Fiske B, Mayers JR, Schwab M, Bellinger G, Csibi A, Patnaik A, Blouin MJ, Cantley LC, Guarente L, Blenis J, et al. Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism. Cancer Research. 73: 4429-38. PMID 23687346 DOI: 10.1158/0008-5472.CAN-13-0080  1
2013 Shinoda G, Shyh-Chang N, Soysa TY, Zhu H, Seligson MT, Shah SP, Abo-Sido N, Yabuuchi A, Hagan JP, Gregory RI, Asara JM, Cantley LC, Moss EG, Daley GQ. Fetal deficiency of lin28 programs life-long aberrations in growth and glucose metabolism. Stem Cells (Dayton, Ohio). 31: 1563-73. PMID 23666760 DOI: 10.1002/stem.1423  1
2013 Csibi A, Fendt SM, Li C, Poulogiannis G, Choo AY, Chapski DJ, Jeong SM, Dempsey JM, Parkhitko A, Morrison T, Henske EP, Haigis MC, Cantley LC, Stephanopoulos G, Yu J, et al. The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4. Cell. 153: 840-54. PMID 23663782 DOI: 10.1016/j.cell.2013.04.023  1
2013 Bettaieb A, Bakke J, Nagata N, Matsuo K, Xi Y, Liu S, AbouBechara D, Melhem R, Stanhope K, Cummings B, Graham J, Bremer A, Zhang S, Lyssiotis CA, Zhang ZY, ... Cantley LC, et al. Protein tyrosine phosphatase 1B regulates pyruvate kinase M2 tyrosine phosphorylation. The Journal of Biological Chemistry. 288: 17360-71. PMID 23640882 DOI: 10.1074/jbc.M112.441469  1
2013 Hu J, Locasale JW, Bielas JH, O'Sullivan J, Sheahan K, Cantley LC, Vander Heiden MG, Vitkup D. Heterogeneity of tumor-induced gene expression changes in the human metabolic network. Nature Biotechnology. 31: 522-9. PMID 23604282 DOI: 10.1038/nbt.2530  1
2013 Gallop JL, Walrant A, Cantley LC, Kirschner MW. Phosphoinositides and membrane curvature switch the mode of actin polymerization via selective recruitment of toca-1 and Snx9. Proceedings of the National Academy of Sciences of the United States of America. 110: 7193-8. PMID 23589871 DOI: 10.1073/pnas.1305286110  1
2013 Sadanandam A, Lyssiotis CA, Homicsko K, Collisson EA, Gibb WJ, Wullschleger S, Ostos LC, Lannon WA, Grotzinger C, Del Rio M, Lhermitte B, Olshen AB, Wiedenmann B, Cantley LC, Gray JW, et al. A colorectal cancer classification system that associates cellular phenotype and responses to therapy. Nature Medicine. 19: 619-25. PMID 23584089 DOI: 10.1038/nm.3175  1
2013 Son J, Lyssiotis CA, Ying H, Wang X, Hua S, Ligorio M, Perera RM, Ferrone CR, Mullarky E, Shyh-Chang N, Kang Y, Fleming JB, Bardeesy N, Asara JM, Haigis MC, ... ... Cantley LC, et al. Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway. Nature. 496: 101-5. PMID 23535601 DOI: 10.1038/nature12040  1
2013 Wu N, Zheng B, Shaywitz A, Dagon Y, Tower C, Bellinger G, Shen CH, Wen J, Asara J, McGraw TE, Kahn BB, Cantley LC. AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1. Molecular Cell. 49: 1167-75. PMID 23453806 DOI: 10.1016/j.molcel.2013.01.035  1
2013 Carracedo A, Cantley LC, Pandolfi PP. Cancer metabolism: fatty acid oxidation in the limelight. Nature Reviews. Cancer. 13: 227-32. PMID 23446547 DOI: 10.1038/nrc3483  1
2013 Emerling BM, Benes CH, Poulogiannis G, Bell EL, Courtney K, Liu H, Choo-Wing R, Bellinger G, Tsukazawa KS, Brown V, Signoretti S, Soltoff SP, Cantley LC. Identification of CDCP1 as a hypoxia-inducible factor 2α (HIF-2α) target gene that is associated with survival in clear cell renal cell carcinoma patients. Proceedings of the National Academy of Sciences of the United States of America. 110: 3483-8. PMID 23378636 DOI: 10.1073/pnas.1222435110  1
2013 Davis MI, Sasaki AT, Shen M, Emerling BM, Thorne N, Michael S, Pragani R, Boxer M, Sumita K, Takeuchi K, Auld DS, Li Z, Cantley LC, Simeonov A. A homogeneous, high-throughput assay for phosphatidylinositol 5-phosphate 4-kinase with a novel, rapid substrate preparation. Plos One. 8: e54127. PMID 23326584 DOI: 10.1371/journal.pone.0054127  1
2013 Baker R, Lewis SM, Sasaki AT, Wilkerson EM, Locasale JW, Cantley LC, Kuhlman B, Dohlman HG, Campbell SL. Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function. Nature Structural & Molecular Biology. 20: 46-52. PMID 23178454 DOI: 10.1038/nsmb.2430  1
2013 Kim SG, Hoffman GR, Poulogiannis G, Buel GR, Jang YJ, Lee KW, Kim BY, Erikson RL, Cantley LC, Choo AY, Blenis J. Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex. Molecular Cell. 49: 172-85. PMID 23142078 DOI: 10.1016/j.molcel.2012.10.003  1
2013 Shyh-Chang N, Locasale JW, Lyssiotis CA, Zheng Y, Teo RY, Ratanasirintrawoot S, Zhang J, Onder T, Unternaehrer JJ, Zhu H, Asara JM, Daley GQ, Cantley LC. Influence of threonine metabolism on S-adenosylmethionine and histone methylation. Science (New York, N.Y.). 339: 222-6. PMID 23118012 DOI: 10.1126/science.1226603  1
2012 Lyssiotis CA, Cantley LC. SIRT6 puts cancer metabolism in the driver's seat. Cell. 151: 1155-6. PMID 23217699 DOI: 10.1016/j.cell.2012.11.020  1
2012 Yang W, Zheng Y, Xia Y, Ji H, Chen X, Guo F, Lyssiotis CA, Aldape K, Cantley LC, Lu Z. ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect. Nature Cell Biology. 14: 1295-304. PMID 23178880 DOI: 10.1038/ncb2629  1
2012 Quayle SN, Lee JY, Cheung LW, Ding L, Wiedemeyer R, Dewan RW, Huang-Hobbs E, Zhuang L, Wilson RK, Ligon KL, Mills GB, Cantley LC, Chin L. Somatic mutations of PIK3R1 promote gliomagenesis. Plos One. 7: e49466. PMID 23166678 DOI: 10.1371/journal.pone.0049466  1
2012 Das S, Aiba T, Rosenberg M, Hessler K, Xiao C, Quintero PA, Ottaviano FG, Knight AC, Graham EL, Boström P, Morissette MR, del Monte F, Begley MJ, Cantley LC, Ellinor PT, et al. Pathological role of serum- and glucocorticoid-regulated kinase 1 in adverse ventricular remodeling. Circulation. 126: 2208-19. PMID 23019294 DOI: 10.1161/CIRCULATIONAHA.112.115592  1
2012 Kung C, Hixon J, Choe S, Marks K, Gross S, Murphy E, DeLaBarre B, Cianchetta G, Sethumadhavan S, Wang X, Yan S, Gao Y, Fang C, Wei W, Jiang F, ... ... Cantley LC, et al. Small molecule activation of PKM2 in cancer cells induces serine auxotrophy. Chemistry & Biology. 19: 1187-98. PMID 22999886 DOI: 10.1016/j.chembiol.2012.07.021  1
2012 Cantley LC, Dalton WS, DuBois RN, Finn OJ, Futreal PA, Golub TR, Hait WN, Lozano G, Maris JM, Nelson WG, Sawyers CL, Schreiber SL, Spitz MR, Steeg PS. AACR Cancer Progress Report 2012. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: S1-100. PMID 22977188 DOI: 10.1158/1078-0432.CCR-12-2891  1
2012 Myers AP, Cantley LC. Sugar free, cancer free? Nutrition (Burbank, Los Angeles County, Calif.). 28: 1036. PMID 22925542 DOI: 10.1016/j.nut.2012.07.004  1
2012 Anastasiou D, Yu Y, Israelsen WJ, Jiang JK, Boxer MB, Hong BS, Tempel W, Dimov S, Shen M, Jha A, Yang H, Mattaini KR, Metallo CM, Fiske BP, Courtney KD, ... ... Cantley LC, et al. Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Nature Chemical Biology. 8: 839-47. PMID 22922757 DOI: 10.1038/nchembio.1060  1
2012 Juvekar A, Burga LN, Hu H, Lunsford EP, Ibrahim YH, Balmañà J, Rajendran A, Papa A, Spencer K, Lyssiotis CA, Nardella C, Pandolfi PP, Baselga J, Scully R, Asara JM, ... Cantley LC, et al. Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast cancer. Cancer Discovery. 2: 1048-63. PMID 22915751 DOI: 10.1158/2159-8290.CD-11-0336  1
2012 Hutti JE, Porter MA, Cheely AW, Cantley LC, Wang X, Kireev D, Baldwin AS, Janzen WP. Development of a high-throughput assay for identifying inhibitors of TBK1 and IKKε. Plos One. 7: e41494. PMID 22859992 DOI: 10.1371/journal.pone.0041494  1
2012 Dagon Y, Hur E, Zheng B, Wellenstein K, Cantley LC, Kahn BB. p70S6 kinase phosphorylates AMPK on serine 491 to mediate leptin's effect on food intake. Cell Metabolism. 16: 104-12. PMID 22727014 DOI: 10.1016/j.cmet.2012.05.010  1
2012 Shaw RJ, Cantley LC. Cell biology. Ancient sensor for ancient drug. Science (New York, N.Y.). 336: 813-4. PMID 22605741 DOI: 10.1126/science.1223140  1
2012 Cantley LC, Baselga J. Cancer Discovery at one year: the editors' interim analysis. Cancer Discovery. 2: vi. PMID 22585178 DOI: 10.1158/2159-8290.CD-11-0327  1
2012 Marinis JM, Hutti JE, Homer CR, Cobb BA, Cantley LC, McDonald C, Abbott DW. IκB kinase α phosphorylation of TRAF4 downregulates innate immune signaling. Molecular and Cellular Biology. 32: 2479-89. PMID 22547678 DOI: 10.1128/MCB.00106-12  1
2012 Ying H, Kimmelman AC, Lyssiotis CA, Hua S, Chu GC, Fletcher-Sananikone E, Locasale JW, Son J, Zhang H, Coloff JL, Yan H, Wang W, Chen S, Viale A, Zheng H, ... ... Cantley LC, et al. Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell. 149: 656-70. PMID 22541435 DOI: 10.1016/j.cell.2012.01.058  1
2012 Chen Z, Cheng K, Walton Z, Wang Y, Ebi H, Shimamura T, Liu Y, Tupper T, Ouyang J, Li J, Gao P, Woo MS, Xu C, Yanagita M, Altabef A, ... ... Cantley LC, et al. A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response. Nature. 483: 613-7. PMID 22425996 DOI: 10.1038/nature10937  1
2012 Garcia-Cao I, Song MS, Hobbs RM, Laurent G, Giorgi C, de Boer VC, Anastasiou D, Ito K, Sasaki AT, Rameh L, Carracedo A, Vander Heiden MG, Cantley LC, Pinton P, Haigis MC, et al. Systemic elevation of PTEN induces a tumor-suppressive metabolic state. Cell. 149: 49-62. PMID 22401813 DOI: 10.1016/j.cell.2012.02.030  1
2012 Comb WC, Hutti JE, Cogswell P, Cantley LC, Baldwin AS. p85α SH2 domain phosphorylation by IKK promotes feedback inhibition of PI3K and Akt in response to cellular starvation. Molecular Cell. 45: 719-30. PMID 22342344 DOI: 10.1016/j.molcel.2012.01.010  1
2012 Shaw RJ, Cantley LC. Decoding key nodes in the metabolism of cancer cells: sugar & spice and all things nice. F1000 Biology Reports. 4: 2. PMID 22242042 DOI: 10.3410/B4-2  1
2012 Locasale JW, Melman T, Song S, Yang X, Swanson KD, Cantley LC, Wong ET, Asara JM. Metabolomics of human cerebrospinal fluid identifies signatures of malignant glioma. Molecular & Cellular Proteomics : McP. 11: M111.014688. PMID 22240505 DOI: 10.1074/mcp.M111.014688  1
2012 Anastasiou D, Cantley LC. Breathless cancer cells get fat on glutamine. Cell Research. 22: 443-6. PMID 22212478 DOI: 10.1038/cr.2012.5  1
2012 Wang Z, Chatterjee D, Jeon HY, Akerman M, Vander Heiden MG, Cantley LC, Krainer AR. Exon-centric regulation of pyruvate kinase M alternative splicing via mutually exclusive exons. Journal of Molecular Cell Biology. 4: 79-87. PMID 22044881 DOI: 10.1093/jmcb/mjr030  1
2012 Benes CH, Poulogiannis G, Cantley LC, Soltoff SP. The SRC-associated protein CUB Domain-Containing Protein-1 regulates adhesion and motility. Oncogene. 31: 653-63. PMID 21725358 DOI: 10.1038/onc.2011.262  1
2012 Hanai J, Doro N, Sasaki AT, Kobayashi S, Cantley LC, Seth P, Sukhatme VP. Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-kinase (PI3K)/AKT pathways. Journal of Cellular Physiology. 227: 1709-20. PMID 21688263 DOI: 10.1002/jcp.22895  1
2012 Shaw RJ, Cantley LC. Ancient sensor for ancient drug Science. 336: 813-814. DOI: 10.1126/science.122314  1
2012 Lyssiotis CA, Anastasiou D, Locasale JW, Vander Heiden MG, Christofk HR, Cantley LC. Cellular control mechanisms that regulate pyruvate kinase M2 activity and promote cancer growth Biomedical Research. 23: 213-217.  1
2011 Woodroof HI, Pogson JH, Begley M, Cantley LC, Deak M, Campbell DG, van Aalten DM, Whitworth AJ, Alessi DR, Muqit MM. Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations. Open Biology. 1: 110012. PMID 22645651 DOI: 10.1098/rsob.110012  1
2011 Cantley LC, Baselga J. The era of cancer discovery. Cancer Discovery. 1: 1. PMID 22586302 DOI: 10.1158/2159-8274.CD-11-0049  1
2011 Vander Heiden MG, Lunt SY, Dayton TL, Fiske BP, Israelsen WJ, Mattaini KR, Vokes NI, Stephanopoulos G, Cantley LC, Metallo CM, Locasale JW. Metabolic pathway alterations that support cell proliferation. Cold Spring Harbor Symposia On Quantitative Biology. 76: 325-34. PMID 22262476 DOI: 10.1101/sqb.2012.76.010900  1
2011 Shyh-Chang N, Zheng Y, Locasale JW, Cantley LC. Human pluripotent stem cells decouple respiration from energy production. The Embo Journal. 30: 4851-2. PMID 22166995 DOI: 10.1038/emboj.2011.436  1
2011 Wang XS, Shankar S, Dhanasekaran SM, Ateeq B, Sasaki AT, Jing X, Robinson D, Cao Q, Prensner JR, Yocum AK, Wang R, Fries DF, Han B, Asangani IA, Cao X, ... ... Cantley LC, et al. Characterization of KRAS rearrangements in metastatic prostate cancer. Cancer Discovery. 1: 35-43. PMID 22140652 DOI: 10.1158/2159-8274.CD-10-0022  1
2011 Banko MR, Allen JJ, Schaffer BE, Wilker EW, Tsou P, White JL, Villén J, Wang B, Kim SR, Sakamoto K, Gygi SP, Cantley LC, Yaffe MB, Shokat KM, Brunet A. Chemical genetic screen for AMPKα2 substrates uncovers a network of proteins involved in mitosis. Molecular Cell. 44: 878-92. PMID 22137581 DOI: 10.1016/j.molcel.2011.11.005  0.84
2011 Nardella C, Lunardi A, Patnaik A, Cantley LC, Pandolfi PP. The APL paradigm and the "co-clinical trial" project. Cancer Discovery. 1: 108-16. PMID 22116793 DOI: 10.1158/2159-8290.CD-11-0061  1
2011 Locasale JW, Cantley LC. Genetic selection for enhanced serine metabolism in cancer development. Cell Cycle (Georgetown, Tex.). 10: 3812-3. PMID 22064516 DOI: 10.4161/cc.10.22.18224  1
2011 Anastasiou D, Poulogiannis G, Asara JM, Boxer MB, Jiang JK, Shen M, Bellinger G, Sasaki AT, Locasale JW, Auld DS, Thomas CJ, Vander Heiden MG, Cantley LC. Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses. Science (New York, N.Y.). 334: 1278-83. PMID 22052977 DOI: 10.1126/science.1211485  1
2011 Gao D, Inuzuka H, Tan MK, Fukushima H, Locasale JW, Liu P, Wan L, Zhai B, Chin YR, Shaik S, Lyssiotis CA, Gygi SP, Toker A, Cantley LC, Asara JM, et al. mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR. Molecular Cell. 44: 290-303. PMID 22017875 DOI: 10.1016/j.molcel.2011.08.030  1
2011 Ebi H, Corcoran RB, Singh A, Chen Z, Song Y, Lifshits E, Ryan DP, Meyerhardt JA, Benes C, Settleman J, Wong KK, Cantley LC, Engelman JA. Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers. The Journal of Clinical Investigation. 121: 4311-21. PMID 21985784 DOI: 10.1172/JCI57909  1
2011 Cheung LW, Hennessy BT, Li J, Yu S, Myers AP, Djordjevic B, Lu Y, Stemke-Hale K, Dyer MD, Zhang F, Ju Z, Cantley LC, Scherer SE, Liang H, Lu KH, et al. High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability. Cancer Discovery. 1: 170-85. PMID 21984976 DOI: 10.1158/2159-8290.CD-11-0039  1
2011 Locasale JW, Cantley LC. Metabolic flux and the regulation of mammalian cell growth. Cell Metabolism. 14: 443-51. PMID 21982705 DOI: 10.1016/j.cmet.2011.07.014  1
2011 Mullarky E, Mattaini KR, Vander Heiden MG, Cantley LC, Locasale JW. PHGDH amplification and altered glucose metabolism in human melanoma. Pigment Cell & Melanoma Research. 24: 1112-5. PMID 21981974 DOI: 10.1111/j.1755-148X.2011.00919.x  1
2011 Walsh MJ, Brimacombe KR, Veith H, Bougie JM, Daniel T, Leister W, Cantley LC, Israelsen WJ, Vander Heiden MG, Shen M, Auld DS, Thomas CJ, Boxer MB. 2-Oxo-N-aryl-1,2,3,4-tetrahydroquinoline-6-sulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase. Bioorganic & Medicinal Chemistry Letters. 21: 6322-7. PMID 21958545 DOI: 10.1016/j.bmcl.2011.08.114  1
2011 Yi CH, Pan H, Seebacher J, Jang IH, Hyberts SG, Heffron GJ, Vander Heiden MG, Yang R, Li F, Locasale JW, Sharfi H, Zhai B, Rodriguez-Mias R, Luithardt H, Cantley LC, et al. Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival. Cell. 146: 607-20. PMID 21854985 DOI: 10.1016/j.cell.2011.06.050  1
2011 Lee JY, Chiu YH, Asara J, Cantley LC. Inhibition of PI3K binding to activators by serine phosphorylation of PI3K regulatory subunit p85alpha Src homology-2 domains. Proceedings of the National Academy of Sciences of the United States of America. 108: 14157-62. PMID 21825134 DOI: 10.1073/pnas.1107747108  1
2011 Locasale JW, Grassian AR, Melman T, Lyssiotis CA, Mattaini KR, Bass AJ, Heffron G, Metallo CM, Muranen T, Sharfi H, Sasaki AT, Anastasiou D, Mullarky E, Vokes NI, Sasaki M, ... ... Cantley LC, et al. Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nature Genetics. 43: 869-74. PMID 21804546 DOI: 10.1038/ng.890  1
2011 Yang X, Turke AB, Qi J, Song Y, Rexer BN, Miller TW, Jänne PA, Arteaga CL, Cantley LC, Engelman JA, Asara JM. Using tandem mass spectrometry in targeted mode to identify activators of class IA PI3K in cancer. Cancer Research. 71: 5965-75. PMID 21775521 DOI: 10.1158/0008-5472.CAN-11-0445  1
2011 Christofk HR, Wu N, Cantley LC, Asara JM. Proteomic screening method for phosphopeptide motif binding proteins using peptide libraries. Journal of Proteome Research. 10: 4158-64. PMID 21774532 DOI: 10.1021/pr200578n  1
2011 Yu Y, Yoon SO, Poulogiannis G, Yang Q, Ma XM, Villén J, Kubica N, Hoffman GR, Cantley LC, Gygi SP, Blenis J. Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science (New York, N.Y.). 332: 1322-6. PMID 21659605 DOI: 10.1126/science.1199484  1
2011 Bouskila M, Esoof N, Gay L, Fang EH, Deak M, Begley MJ, Cantley LC, Prescott A, Storey KG, Alessi DR. TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development. The Biochemical Journal. 437: 157-67. PMID 21548880 DOI: 10.1042/BJ20110276  1
2011 Saci A, Cantley LC, Carpenter CL. Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size. Molecular Cell. 42: 50-61. PMID 21474067 DOI: 10.1016/j.molcel.2011.03.017  1
2011 Tsou P, Zheng B, Hsu CH, Sasaki AT, Cantley LC. A fluorescent reporter of AMPK activity and cellular energy stress. Cell Metabolism. 13: 476-86. PMID 21459332 DOI: 10.1016/j.cmet.2011.03.006  1
2011 Sasaki AT, Carracedo A, Locasale JW, Anastasiou D, Takeuchi K, Kahoud ER, Haviv S, Asara JM, Pandolfi PP, Cantley LC. Ubiquitination of K-Ras enhances activation and facilitates binding to select downstream effectors. Science Signaling. 4: ra13. PMID 21386094 DOI: 10.1126/scisignal.2001518  1
2011 Yuan TL, Wulf G, Burga L, Cantley LC. Cell-to-cell variability in PI3K protein level regulates PI3K-AKT pathway activity in cell populations. Current Biology : Cb. 21: 173-83. PMID 21256021 DOI: 10.1016/j.cub.2010.12.047  1
2010 Kaneko K, Ueki K, Takahashi N, Hashimoto S, Okamoto M, Awazawa M, Okazaki Y, Ohsugi M, Inabe K, Umehara T, Yoshida M, Kakei M, Kitamura T, Luo J, Kulkarni RN, ... ... Cantley LC, et al. Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanisms. Cell Metabolism. 12: 619-32. PMID 21109194 DOI: 10.1016/j.cmet.2010.11.005  1
2010 Locasale JW, Vander Heiden MG, Cantley LC. Rewiring of glycolysis in cancer cell metabolism. Cell Cycle (Georgetown, Tex.). 9: 4253. PMID 21045562 DOI: 10.4161/cc.9.21.13925  1
2010 Vander Heiden MG, Locasale JW, Swanson KD, Sharfi H, Heffron GJ, Amador-Noguez D, Christofk HR, Wagner G, Rabinowitz JD, Asara JM, Cantley LC. Evidence for an alternative glycolytic pathway in rapidly proliferating cells. Science (New York, N.Y.). 329: 1492-9. PMID 20847263 DOI: 10.1126/science.1188015  1
2010 Myers AP, Cantley LC. Targeting a common collaborator in cancer development. Science Translational Medicine. 2: 48ps45. PMID 20826838 DOI: 10.1126/scitranslmed.3001251  1
2010 Engelman JA, Cantley LC. Chemoprevention meets glucose control. Cancer Prevention Research (Philadelphia, Pa.). 3: 1049-52. PMID 20810671 DOI: 10.1158/1940-6207.CAPR-10-0178  1
2010 Baba Y, Nosho K, Shima K, Meyerhardt JA, Chan AT, Engelman JA, Cantley LC, Loda M, Giovannucci E, Fuchs CS, Ogino S. Prognostic significance of AMP-activated protein kinase expression and modifying effect of MAPK3/1 in colorectal cancer. British Journal of Cancer. 103: 1025-33. PMID 20808308 DOI: 10.1038/sj.bjc.6605846  1
2010 Moritz A, Li Y, Guo A, Villén J, Wang Y, MacNeill J, Kornhauser J, Sprott K, Zhou J, Possemato A, Ren JM, Hornbeck P, Cantley LC, Gygi SP, Rush J, et al. Akt-RSK-S6 kinase signaling networks activated by oncogenic receptor tyrosine kinases. Science Signaling. 3: ra64. PMID 20736484 DOI: 10.1126/scisignal.2000998  1
2010 Poulogiannis G, McIntyre RE, Dimitriadi M, Apps JR, Wilson CH, Ichimura K, Luo F, Cantley LC, Wyllie AH, Adams DJ, Arends MJ. PARK2 deletions occur frequently in sporadic colorectal cancer and accelerate adenoma development in Apc mutant mice. Proceedings of the National Academy of Sciences of the United States of America. 107: 15145-50. PMID 20696900 DOI: 10.1073/pnas.1009941107  1
2010 Locasale JW, Cantley LC. Altered metabolism in cancer. Bmc Biology. 8: 88. PMID 20598111 DOI: 10.1186/1741-7007-8-88  1
2010 Yuan TL, Cantley LC. Introduction. Current Topics in Microbiology and Immunology. 346: 1-7. PMID 20582535 DOI: 10.1007/82_2010_55  1
2010 Dang L, White DW, Gross S, Bennett BD, Bittinger MA, Driggers EM, Fantin VR, Jang HG, Jin S, Keenan MC, Marks KM, Prins RM, Ward PS, Yen KE, Liau LM, ... ... Cantley LC, et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature. 465: 966. PMID 20559394 DOI: 10.1038/nature09132  1
2010 Lee SH, Poulogiannis G, Pyne S, Jia S, Zou L, Signoretti S, Loda M, Cantley LC, Roberts TM. A constitutively activated form of the p110beta isoform of PI3-kinase induces prostatic intraepithelial neoplasia in mice. Proceedings of the National Academy of Sciences of the United States of America. 107: 11002-7. PMID 20534477 DOI: 10.1073/pnas.1005642107  1
2010 Taniguchi CM, Winnay J, Kondo T, Bronson RT, Guimaraes AR, Alemán JO, Luo J, Stephanopoulos G, Weissleder R, Cantley LC, Kahn CR. The phosphoinositide 3-kinase regulatory subunit p85alpha can exert tumor suppressor properties through negative regulation of growth factor signaling. Cancer Research. 70: 5305-15. PMID 20530665 DOI: 10.1158/0008-5472.CAN-09-3399  1
2010 Choo AY, Kim SG, Vander Heiden MG, Mahoney SJ, Vu H, Yoon SO, Cantley LC, Blenis J. Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply. Molecular Cell. 38: 487-99. PMID 20513425 DOI: 10.1016/j.molcel.2010.05.007  1
2010 Leissring MA, Malito E, Hedouin S, Reinstatler L, Sahara T, Abdul-Hay SO, Choudhry S, Maharvi GM, Fauq AH, Huzarska M, May PS, Choi S, Logan TP, Turk BE, Cantley LC, et al. Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin. Plos One. 5: e10504. PMID 20498699 DOI: 10.1371/journal.pone.0010504  1
2010 Jiang JK, Boxer MB, Vander Heiden MG, Shen M, Skoumbourdis AP, Southall N, Veith H, Leister W, Austin CP, Park HW, Inglese J, Cantley LC, Auld DS, Thomas CJ. Evaluation of thieno[3,2-b]pyrrole[3,2-d]pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase. Bioorganic & Medicinal Chemistry Letters. 20: 3387-93. PMID 20451379 DOI: 10.1016/j.bmcl.2010.04.015  1
2010 Clower CV, Chatterjee D, Wang Z, Cantley LC, Vander Heiden MG, Krainer AR. The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism. Proceedings of the National Academy of Sciences of the United States of America. 107: 1894-9. PMID 20133837 DOI: 10.1073/pnas.0914845107  1
2010 Takeuchi H, Takeuchi T, Gao J, Cantley LC, Hirata M. Characterization of PXK as a protein involved in epidermal growth factor receptor trafficking. Molecular and Cellular Biology. 30: 1689-702. PMID 20086096 DOI: 10.1128/MCB.01105-09  1
2010 Boxer MB, Jiang JK, Vander Heiden MG, Shen M, Skoumbourdis AP, Southall N, Veith H, Leister W, Austin CP, Park HW, Inglese J, Cantley LC, Auld DS, Thomas CJ. Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase. Journal of Medicinal Chemistry. 53: 1048-55. PMID 20017496 DOI: 10.1021/jm901577g  1
2010 Wong KK, Engelman JA, Cantley LC. Targeting the PI3K signaling pathway in cancer. Current Opinion in Genetics & Development. 20: 87-90. PMID 20006486 DOI: 10.1016/j.gde.2009.11.002  1
2010 Vander Heiden MG, Christofk HR, Schuman E, Subtelny AO, Sharfi H, Harlow EE, Xian J, Cantley LC. Identification of small molecule inhibitors of pyruvate kinase M2. Biochemical Pharmacology. 79: 1118-24. PMID 20005212 DOI: 10.1016/j.bcp.2009.12.003  1
2010 Shiga K, Takayama K, Futaki S, Hutti JE, Cantley LC, Ueki K, Ono Y, Mukai H. Development of an intracellularly acting inhibitory peptide selective for PKN. The Biochemical Journal. 425: 445-53. PMID 19857203 DOI: 10.1042/BJ20090380  1
2009 Dang L, White DW, Gross S, Bennett BD, Bittinger MA, Driggers EM, Fantin VR, Jang HG, Jin S, Keenan MC, Marks KM, Prins RM, Ward PS, Yen KE, Liau LM, ... ... Cantley LC, et al. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature. 462: 739-44. PMID 19935646 DOI: 10.1038/nature08617  1
2009 Hitosugi T, Kang S, Vander Heiden MG, Chung TW, Elf S, Lythgoe K, Dong S, Lonial S, Wang X, Chen GZ, Xie J, Gu TL, Polakiewicz RD, Roesel JL, Boggon TJ, ... ... Cantley LC, et al. Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth. Science Signaling. 2: ra73. PMID 19920251 DOI: 10.1126/scisignal.2000431  1
2009 Myers AP, Meyerhardt JA, Cantley LC. Getting knit-PI3Ky: PIK3CA mutation status to direct multimodality therapy? Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 6748-50. PMID 19903790 DOI: 10.1158/1078-0432.CCR-09-2305  1
2009 Smith RA, Yuan H, Weissleder R, Cantley LC, Josephson L. A wortmannin-cetuximab as a double drug. Bioconjugate Chemistry. 20: 2185-9. PMID 19883074 DOI: 10.1021/bc900176a  1
2009 Hill JW, Xu Y, Preitner F, Fukuda M, Cho YR, Luo J, Balthasar N, Coppari R, Cantley LC, Kahn BB, Zhao JJ, Elmquist JK. Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis. Endocrinology. 150: 4874-82. PMID 19819947 DOI: 10.1210/en.2009-0454  1
2009 Locasale JW, Cantley LC, Vander Heiden MG. Cancer's insatiable appetite. Nature Biotechnology. 27: 916-7. PMID 19816448 DOI: 10.1038/nbt1009-916  1
2009 Nichols RJ, Dzamko N, Hutti JE, Cantley LC, Deak M, Moran J, Bamborough P, Reith AD, Alessi DR. Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease. The Biochemical Journal. 424: 47-60. PMID 19740074 DOI: 10.1042/BJ20091035  1
2009 Mouta-Bellum C, Kirov A, Miceli-Libby L, Mancini ML, Petrova TV, Liaw L, Prudovsky I, Thorpe PE, Miura N, Cantley LC, Alitalo K, Fruman DA, Vary CP. Organ-specific lymphangiectasia, arrested lymphatic sprouting, and maturation defects resulting from gene-targeting of the PI3K regulatory isoforms p85alpha, p55alpha, and p50alpha. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 238: 2670-9. PMID 19705443 DOI: 10.1002/dvdy.22078  1
2009 Cantley LC. Lewis C. Cantley. Current Biology : Cb. 19: R540-1. PMID 19655422  1
2009 Gewinner C, Wang ZC, Richardson A, Teruya-Feldstein J, Etemadmoghadam D, Bowtell D, Barretina J, Lin WM, Rameh L, Salmena L, Pandolfi PP, Cantley LC. Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling. Cancer Cell. 16: 115-25. PMID 19647222 DOI: 10.1016/j.ccr.2009.06.006  1
2009 Smith A, Blois J, Yuan H, Aikawa E, Ellson C, Figueiredo JL, Weissleder R, Kohler R, Yaffe MB, Cantley LC, Josephson L. The antiproliferative cytostatic effects of a self-activating viridin prodrug. Molecular Cancer Therapeutics. 8: 1666-75. PMID 19509266 DOI: 10.1158/1535-7163.MCT-08-1012  1
2009 Hutti JE, Shen RR, Abbott DW, Zhou AY, Sprott KM, Asara JM, Hahn WC, Cantley LC. Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKepsilon promotes cell transformation. Molecular Cell. 34: 461-72. PMID 19481526 DOI: 10.1016/j.molcel.2009.04.031  1
2009 Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science (New York, N.Y.). 324: 1029-33. PMID 19460998 DOI: 10.1126/science.1160809  1
2009 Schweitzer MH, Zheng W, Organ CL, Avci R, Suo Z, Freimark LM, Lebleu VS, Duncan MB, Vander Heiden MG, Neveu JM, Lane WS, Cottrell JS, Horner JR, Cantley LC, Kalluri R, et al. Biomolecular characterization and protein sequences of the Campanian hadrosaur B. canadensis. Science (New York, N.Y.). 324: 626-31. PMID 19407199 DOI: 10.1126/science.1165069  1
2009 Ogino S, Nosho K, Kirkner GJ, Shima K, Irahara N, Kure S, Chan AT, Engelman JA, Kraft P, Cantley LC, Giovannucci EL, Fuchs CS. PIK3CA mutation is associated with poor prognosis among patients with curatively resected colon cancer Journal of Clinical Oncology. 27: 1477-1484. PMID 19237633 DOI: 10.1200/JCO.2008.18.6544  1
2009 Nicklin P, Bergman P, Zhang B, Triantafellow E, Wang H, Nyfeler B, Yang H, Hild M, Kung C, Wilson C, Myer VE, MacKeigan JP, Porter JA, Wang YK, Cantley LC, et al. Bidirectional transport of amino acids regulates mTOR and autophagy. Cell. 136: 521-34. PMID 19203585 DOI: 10.1016/j.cell.2008.11.044  1
2009 Zheng B, Jeong JH, Asara JM, Yuan YY, Granter SR, Chin L, Cantley LC. Oncogenic B-RAF Negatively Regulates the Tumor Suppressor LKB1 to Promote Melanoma Cell Proliferation Molecular Cell. 33: 237-247. PMID 19187764 DOI: 10.1016/j.molcel.2008.12.026  1
2009 Oak JS, Deane JA, Kharas MG, Luo J, Lane TE, Cantley LC, Fruman DA. Sjögren's syndrome-like disease in mice with T cells lacking class 1A phosphoinositide-3-kinase (Proceedings of the National Academy of Sciences of the United States of America (2009) 103, 45, (16882-16887) 10.1073/pnas. 0607984103) Proceedings of the National Academy of Sciences of the United States of America. 106: 10871. DOI: 10.1073/pnas.0905401106  1
2008 Engelman JA, Chen L, Tan X, Crosby K, Guimaraes AR, Upadhyay R, Maira M, McNamara K, Perera SA, Song Y, Chirieac LR, Kaur R, Lightbown A, Simendinger J, Li T, ... ... Cantley LC, et al. Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. Nature Medicine. 14: 1351-6. PMID 19029981 DOI: 10.1038/nm.1890  1
2008 Yuan TL, Cantley LC. PI3K pathway alterations in cancer: variations on a theme. Oncogene. 27: 5497-510. PMID 18794884 DOI: 10.1038/onc.2008.245  0.8
2008 Shaywitz AJ, Courtney KD, Patnaik A, Cantley LC. PI3K enters beta-testing. Cell Metabolism. 8: 179-81. PMID 18762017 DOI: 10.1016/j.cmet.2008.08.011  1
2008 Carracedo A, Ma L, Teruya-Feldstein J, Rojo F, Salmena L, Alimonti A, Egia A, Sasaki AT, Thomas G, Kozma SC, Papa A, Nardella C, Cantley LC, Baselga J, Pandolfi PP. Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer Journal of Clinical Investigation. 118: 3065-3074. PMID 18725988 DOI: 10.1172/JCI34739  1
2008 Blois J, Yuan H, Smith A, Pacold ME, Weissleder R, Cantley LC, Josephson L. Slow self-activation enhances the potency of viridin prodrugs. Journal of Medicinal Chemistry. 51: 4699-707. PMID 18630894 DOI: 10.1021/jm800374f  1
2008 Yuan TL, Choi HS, Matsui A, Benes C, Lifshits E, Luo J, Frangioni JV, Cantley LC. Class 1A PI3K regulates vessel integrity during development and tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America. 105: 9739-44. PMID 18621722 DOI: 10.1073/pnas.0804123105  1
2008 Engelman JA, Cantley LC. A Sweet New Role for EGFR in Cancer Cancer Cell. 13: 375-376. PMID 18455118 DOI: 10.1016/j.ccr.2008.04.008  1
2008 Organ CL, Schweitzer MH, Zheng W, Freimark LM, Cantley LC, Asara JM. Molecular phylogenetics of mastodon and Tyrannosaurus rex. Science (New York, N.Y.). 320: 499. PMID 18436782 DOI: 10.1126/science.1154284  1
2008 Hill JW, Williams KW, Ye C, Luo J, Balthasar N, Coppari R, Cowley MA, Cantley LC, Lowell BB, Elmquist JK. Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice. The Journal of Clinical Investigation. 118: 1796-805. PMID 18382766 DOI: 10.1172/JCI32964  1
2008 Christofk HR, Vander Heiden MG, Harris MH, Ramanathan A, Gerszten RE, Wei R, Fleming MD, Schreiber SL, Cantley LC. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature. 452: 230-3. PMID 18337823 DOI: 10.1038/nature06734  1
2008 Christofk HR, Vander Heiden MG, Wu N, Asara JM, Cantley LC. Pyruvate kinase M2 is a phosphotyrosine-binding protein Nature. 452: 181-186. PMID 18337815 DOI: 10.1038/nature06667  1
2008 Asara JM, Christofk HR, Freimark LM, Cantley LC. A label-free quantification method by MS/MS TIC compared to SILAC and spectral counting in a proteomics screen Proteomics. 8: 994-999. PMID 18324724 DOI: 10.1002/pmic.200700426  1
2008 Barnes KR, Blois J, Smith A, Yuan H, Reynolds F, Weissleder R, Cantley LC, Josephson L. Fate of a bioactive fluorescent wortmannin derivative in cells. Bioconjugate Chemistry. 19: 130-7. PMID 17988080 DOI: 10.1021/bc7002204  1
2008 Asara JM, Schweitzer MH, Cantley LC, Cottrell JS. Response to comment on "Protein sequences from mastodon and Tyrannosaurus rex revealed by mass spectrometry" Science. 321: 1040c. DOI: 10.1126/science.1157829  1
2007 Asara JM, Garavelli JS, Slatter DA, Schweitzer MH, Freimark LM, Phillips M, Cantley LC. Interpreting sequences from mastodon and T. rex. Science (New York, N.Y.). 317: 1324-5. PMID 17823333 DOI: 10.1126/science.317.5843.1324  1
2007 Hutti JE, Turk BE, Asara JM, Ma A, Cantley LC, Abbott DW. IκB kinase β phosphorylates the K63 deubiquitinase A20 to cause feedback inhibition of the NF-κB pathway Molecular and Cellular Biology. 27: 7451-7461. PMID 17709380 DOI: 10.1128/MCB.01101-07  1
2007 Lee JY, Engelman JA, Cantley LC. PI3K charges ahead Science. 317: 206-207. PMID 17626872 DOI: 10.1126/science.1146073  1
2007 Manning BD, Cantley LC. AKT/PKB signaling: navigating downstream. Cell. 129: 1261-74. PMID 17604717 DOI: 10.1016/j.cell.2007.06.009  1
2007 Abbott DW, Yang Y, Hutti JE, Madhavarapu S, Kelliher MA, Cantley LC. Coordinated regulation of toll-like receptor and NOD2 signaling by K63-linked polyubiquitin chains Molecular and Cellular Biology. 27: 6012-6025. PMID 17562858 DOI: 10.1128/MCB.00270-07  1
2007 Chang JD, Sukhova GK, Libby P, Schvartz E, Lichtenstein AH, Field SJ, Kennedy C, Madhavarapu S, Luo J, Wu D, Cantley LC. Deletion of the phosphoinositide 3-kinase p110gamma gene attenuates murine atherosclerosis. Proceedings of the National Academy of Sciences of the United States of America. 104: 8077-82. PMID 17483449 DOI: 10.1073/pnas.0702663104  1
2007 Engelman JA, Zejnullahu K, Mitsudomi T, Song Y, Hyland C, Park JO, Lindeman N, Gale CM, Zhao X, Christensen J, Kosaka T, Holmes AJ, Rogers AM, Cappuzzo F, Mok T, ... ... Cantley LC, et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science (New York, N.Y.). 316: 1039-43. PMID 17463250 DOI: 10.1126/science.1141478  1
2007 Perry B, Banyard J, McLaughlin ER, Watnick R, Sohn A, Brindley DN, Obata T, Cantley LC, Cohen C, Arbiser JL. AKT1 overexpression in endothelial cells leads to the development of cutaneous vascular malformations in vivo Archives of Dermatology. 143: 504-506. PMID 17438183 DOI: 10.1001/archderm.143.4.504  1
2007 Asara JM, Schweitzer MH, Freimark LM, Phillips M, Cantley LC. Protein sequences from mastodon and Tyrannosaurus rex revealed by mass spectrometry. Science (New York, N.Y.). 316: 280-5. PMID 17431180 DOI: 10.1126/science.1137614  1
2007 Hurov JB, Huang M, White LS, Lennerz J, Choi CS, Cho YR, Kim HJ, Prior JL, Piwnica-Worms D, Cantley LC, Kim JK, Shulman GI, Piwnica-Worms H. Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo. Proceedings of the National Academy of Sciences of the United States of America. 104: 5680-5. PMID 17372192 DOI: 10.1073/pnas.0701179104  1
2007 Holt LJ, Hutti JE, Cantley LC, Morgan DO. Evolution of Ime2 phosphorylation sites on Cdk1 substrates provides a mechanism to limit the effects of the phosphatase Cdc14 in meiosis. Molecular Cell. 25: 689-702. PMID 17349956 DOI: 10.1016/j.molcel.2007.02.012  1
2007 Taniguchi CM, Aleman JO, Ueki K, Luo J, Asano T, Kaneto H, Stephanopoulos G, Cantley LC, Kahn CR. The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance. Molecular and Cellular Biology. 27: 2830-40. PMID 17283057 DOI: 10.1128/MCB.00079-07  1
2007 Zheng B, Cantley LC. Regulation of epithelial tight junction assembly and disassembly by AMP-activated protein kinase Proceedings of the National Academy of Sciences of the United States of America. 104: 819-822. PMID 17204563 DOI: 10.1073/pnas.0610157104  1
2007 Deane JA, Kharas MG, Oak JS, Stiles LN, Luo J, Moore TI, Ji H, Rommel C, Cantley LC, Lane TE, Fruman DA. T-cell function is partially maintained in the absence of class IA phosphoinositide 3-kinase signaling. Blood. 109: 2894-902. PMID 17164340 DOI: 10.1182/blood-2006-07-038620  1
2006 Turk BE, Hutti JE, Cantley LC. Determining protein kinase substrate specificity by parallel solution-phase assay of large numbers of peptide substrates Nature Protocols. 1: 375-379. PMID 17406259 DOI: 10.1038/nprot.2006.57  1
2006 Asara JM, Zhang X, Zheng B, Maroney LA, Christofk HR, Wu N, Cantley LC. In-gel stable isotope labeling for relative quantification using mass spectrometry Nature Protocols. 1: 46-51. PMID 17406210 DOI: 10.1038/nprot.2006.7  1
2006 Oak JS, Deane JA, Kharas MG, Luo J, Lane TE, Cantley LC, Fruman DA. Sjögren's syndrome-like disease in mice with T cells lacking class 1A phosphoinositide-3-kinase. Proceedings of the National Academy of Sciences of the United States of America. 103: 16882-7. PMID 17071741 DOI: 10.1073/pnas.0607984103  1
2006 Engelman JA, Mukohara T, Zejnullahu K, Lifshits E, Borrás AM, Gale CM, Naumov GN, Yeap BY, Jarrell E, Sun J, Tracy S, Zhao X, Heymach JV, Johnson BE, Cantley LC, et al. Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer. The Journal of Clinical Investigation. 116: 2695-706. PMID 16906227 DOI: 10.1172/JCI28656  1
2006 Taniguchi CM, Tran TT, Kondo T, Luo J, Ueki K, Cantley LC, Kahn CR. Phosphoinositide 3-kinase regulatory subunit p85alpha suppresses insulin action via positive regulation of PTEN. Proceedings of the National Academy of Sciences of the United States of America. 103: 12093-7. PMID 16880400 DOI: 10.1073/pnas.0604628103  1
2006 Engelman JA, Cantley LC, Haber D, Settleman J, Bunn P, Johnson B, Heymach J, Goss G, Lynch T. The role of the ErbB family members in non-small cell lung cancers sensitive to epidermal growth factor receptor kinase inhibitors Clinical Cancer Research. 12: 4372s-4376s. PMID 16857813 DOI: 10.1158/1078-0432.CCR-06-0795  1
2006 Engelman JA, Luo J, Cantley LC. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nature Reviews. Genetics. 7: 606-19. PMID 16847462 DOI: 10.1038/nrg1879  1
2006 Shaw RJ, Cantley LC. Ras, PI(3)K and mTOR signalling controls tumour cell growth Nature. 441: 424-430. PMID 16724053 DOI: 10.1038/nature04869  1
2006 Luo J, Sobkiw CL, Hirshman MF, Logsdon MN, Li TQ, Goodyear LJ, Cantley LC. Loss of class IA PI3K signaling in muscle leads to impaired muscle growth, insulin response, and hyperlipidemia. Cell Metabolism. 3: 355-66. PMID 16679293 DOI: 10.1016/j.cmet.2006.04.003  1
2006 Taniguchi CM, Kondo T, Sajan M, Luo J, Bronson R, Asano T, Farese R, Cantley LC, Kahn CR. Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta. Cell Metabolism. 3: 343-53. PMID 16679292 DOI: 10.1016/j.cmet.2006.04.005  1
2006 Turk BE, Lee DH, Yamakoshi Y, Klingenhoff A, Reichenberger E, Wright JT, Simmer JP, Komisarof JA, Cantley LC, Bartlett JD. MMP-20 is predominately a tooth-specific enzyme with a deep catalytic pocket that hydrolyzes type V collagen Biochemistry. 45: 3863-3874. PMID 16548514 DOI: 10.1021/bi052252o  1
2006 Schulze H, Korpal M, Hurov J, Kim SW, Zhang J, Cantley LC, Graf T, Shivdasani RA. Characterization of the megakaryocyte demarcation membrane system and its role in thrombopoiesis Blood. 107: 3868-3875. PMID 16434494 DOI: 10.1182/blood-2005-07-2755  1
2006 Weiner OD, Rentel MC, Ott A, Brown GE, Jedrychowski M, Yaffe MB, Gygi SP, Cantley LC, Bourne HR, Kirschner MW. Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis. Plos Biology. 4: e38. PMID 16417406 DOI: 10.1371/journal.pbio.0040038  1
2006 Asara JM, Zhang X, Zheng B, Christofk HH, Wu N, Cantley LC. In-gel Stable-Isotope Labeling (ISIL): A strategy for mass spectrometry-based relative quantification Journal of Proteome Research. 5: 155-163. PMID 16396506 DOI: 10.1021/pr050334t  1
2005 Isakoff SJ, Engelman JA, Irie HY, Luo J, Brachmann SM, Pearline RV, Cantley LC, Brugge JS. Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells. Cancer Research. 65: 10992-1000. PMID 16322248 DOI: 10.1158/0008-5472.CAN-05-2612  1
2005 Shaw RJ, Lamia KA, Vasquez D, Koo SH, Bardeesy N, Depinho RA, Montminy M, Cantley LC. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science (New York, N.Y.). 310: 1642-6. PMID 16308421 DOI: 10.1126/science.1120781  1
2005 Luo J, McMullen JR, Sobkiw CL, Zhang L, Dorfman AL, Sherwood MC, Logsdon MN, Horner JW, DePinho RA, Izumo S, Cantley LC. Class IA phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophy. Molecular and Cellular Biology. 25: 9491-502. PMID 16227599 DOI: 10.1128/MCB.25.21.9491-9502.2005  1
2005 Gozani O, Field SJ, Ferguson CG, Ewalt M, Mahlke C, Cantley LC, Prestwich GD, Yuan J. Modification of protein sub-nuclear localization by synthetic phosphoinositides: evidence for nuclear phosphoinositide signaling mechanisms. Advances in Enzyme Regulation. 45: 171-85. PMID 16199078 DOI: 10.1016/j.advenzreg.2005.02.010  1
2005 Luo J, Cantley LC. The negative regulation of phosphoinositide 3-kinase signaling by p85 and it's implication in cancer. Cell Cycle (Georgetown, Tex.). 4: 1309-12. PMID 16131837  1
2005 Field SJ, Madson N, Kerr ML, Galbraith KA, Kennedy CE, Tahiliani M, Wilkins A, Cantley LC. PtdIns(4,5)P2 functions at the cleavage furrow during cytokinesis. Current Biology : Cb. 15: 1407-12. PMID 16085494 DOI: 10.1016/j.cub.2005.06.059  1
2005 Luo J, Field SJ, Lee JY, Engelman JA, Cantley LC. The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex. The Journal of Cell Biology. 170: 455-64. PMID 16043515 DOI: 10.1083/jcb.200503088  1
2005 Luo J, Sobkiw CL, Logsdon NM, Watt JM, Signoretti S, O'Connell F, Shin E, Shim Y, Pao L, Neel BG, Depinho RA, Loda M, Cantley LC. Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice by the p85 regulatory subunits of phosphoinositide 3-kinase. Proceedings of the National Academy of Sciences of the United States of America. 102: 10238-43. PMID 16006513 DOI: 10.1073/pnas.0504378102  1
2005 Benes CH, Wu N, Elia AE, Dharia T, Cantley LC, Soltoff SP. The C2 domain of PKCdelta is a phosphotyrosine binding domain. Cell. 121: 271-80. PMID 15851033 DOI: 10.1016/j.cell.2005.02.019  0.36
2005 Brachmann SM, Yballe CM, Innocenti M, Deane JA, Fruman DA, Thomas SM, Cantley LC. Role of phosphoinositide 3-kinase regulatory isoforms in development and actin rearrangement. Molecular and Cellular Biology. 25: 2593-606. PMID 15767666 DOI: 10.1128/MCB.25.7.2593-2606.2005  1
2004 Turk BE, Cantley LC. Peptide libraries: at the crossroads of proteomics and bioinformatics. Drug Discovery Today. 9: S47-52. PMID 23573644  0.8
2004 Hutti JE, Jarrell ET, Chang JD, Abbott DW, Storz P, Toker A, Cantley LC, Turk BE. A rapid method for determining protein kinase phosphorylation specificity. Nature Methods. 1: 27-9. PMID 15782149 DOI: 10.1038/nmeth708  0.8
2004 Mitra P, Zhang Y, Rameh LE, Ivshina MP, McCollum D, Nunnari JJ, Hendricks GM, Kerr ML, Field SJ, Cantley LC, Ross AH. A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast. The Journal of Cell Biology. 166: 205-11. PMID 15249580 DOI: 10.1083/jcb.200404150  1
2004 Williamson AL, Lecchi P, Turk BE, Choe Y, Hotez PJ, McKerrow JH, Cantley LC, Sajid M, Craik CS, Loukas A. A multi-enzyme cascade of hemoglobin proteolysis in the intestine of blood-feeding hookworms. The Journal of Biological Chemistry. 279: 35950-7. PMID 15199048 DOI: 10.1074/jbc.M405842200  1
2004 Lamia KA, Peroni OD, Kim YB, Rameh LE, Kahn BB, Cantley LC. Increased insulin sensitivity and reduced adiposity in phosphatidylinositol 5-phosphate 4-kinase beta-/- mice. Molecular and Cellular Biology. 24: 5080-7. PMID 15143198 DOI: 10.1128/MCB.24.11.5080-5087.2004  1
2004 Turk BE, Cantley LC. Using peptide libraries to identify optimal cleavage motifs for proteolytic enzymes. Methods (San Diego, Calif.). 32: 398-405. PMID 15003602 DOI: 10.1016/j.ymeth.2003.10.003  0.8
2004 Panchal RG, Hermone AR, Nguyen TL, Wong TY, Schwarzenbacher R, Schmidt J, Lane D, McGrath C, Turk BE, Burnett J, Aman MJ, Little S, Sausville EA, Zaharevitz DW, Cantley LC, et al. Identification of small molecule inhibitors of anthrax lethal factor Nature Structural and Molecular Biology. 11: 67-72. PMID 14718925 DOI: 10.1038/nsmb711  1
2004 Turk BE, Wong TY, Schwarzenbacher R, Jarrell ET, Leppla SH, Collier RJ, Liddington RC, Cantley LC. The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor. Nature Structural & Molecular Biology. 11: 60-6. PMID 14718924 DOI: 10.1038/nsmb708  1
2004 Chang JD, Field SJ, Rameh LE, Carpenter CL, Cantley LC. Identification and characterization of a phosphoinositide phosphate kinase homolog. The Journal of Biological Chemistry. 279: 11672-9. PMID 14701839 DOI: 10.1074/jbc.M309721200  0.68
2003 Luo J, Manning BD, Cantley LC. Targeting the PI3K-Akt pathway in human cancer: rationale and promise. Cancer Cell. 4: 257-62. PMID 14585353 DOI: 10.1016/S1535-6108(03)00248-4  1
2003 Elia AE, Rellos P, Haire LF, Chao JW, Ivins FJ, Hoepker K, Mohammad D, Cantley LC, Smerdon SJ, Yaffe MB. The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain. Cell. 115: 83-95. PMID 14532005 DOI: 10.1016/S0092-8674(03)00725-6  1
2003 Martins LM, Turk BE, Cowling V, Borg A, Jarrell ET, Cantley LC, Downward J. Binding specificity and regulation of the serine protease and PDZ domains of HtrA2/Omi. The Journal of Biological Chemistry. 278: 49417-27. PMID 14512424 DOI: 10.1074/jbc.M308659200  1
2003 Ueki K, Fruman DA, Yballe CM, Fasshauer M, Klein J, Asano T, Cantley LC, Kahn CR. Positive and negative roles of p85 alpha and p85 beta regulatory subunits of phosphoinositide 3-kinase in insulin signaling. The Journal of Biological Chemistry. 278: 48453-66. PMID 14504291 DOI: 10.1074/jbc.M305602200  1
2003 Carricaburu V, Lamia KA, Lo E, Favereaux L, Payrastre B, Cantley LC, Rameh LE. The phosphatidylinositol (PI)-5-phosphate 4-kinase type II enzyme controls insulin signaling by regulating PI-3,4,5-trisphosphate degradation. Proceedings of the National Academy of Sciences of the United States of America. 100: 9867-72. PMID 12897244 DOI: 10.1073/pnas.1734038100  1
2003 Gozani O, Karuman P, Jones DR, Ivanov D, Cha J, Lugovskoy AA, Baird CL, Zhu H, Field SJ, Lessnick SL, Villasenor J, Mehrotra B, Chen J, Rao VR, Brugge JS, ... ... Cantley LC, et al. The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor. Cell. 114: 99-111. PMID 12859901 DOI: 10.1016/S0092-8674(03)00480-X  1
2003 Obenauer JC, Cantley LC, Yaffe MB. Scansite 2.0: Proteome-wide prediction of cell signaling interactions using short sequence motifs. Nucleic Acids Research. 31: 3635-41. PMID 12824383 DOI: 10.1093/nar/gkg584  1
2003 Elia AE, Cantley LC, Yaffe MB. Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates. Science (New York, N.Y.). 299: 1228-31. PMID 12595692 DOI: 10.1126/science.1079079  1
2003 Turk BE, Cantley LC. Peptide libraries: at the crossroads of proteomics and bioinformatics. Current Opinion in Chemical Biology. 7: 84-90. PMID 12547431  0.8
2002 Park HI, Turk BE, Gerkema FE, Cantley LC, Sang QX. Peptide substrate specificities and protein cleavage sites of human endometase/matrilysin-2/matrix metalloproteinase-26. The Journal of Biological Chemistry. 277: 35168-75. PMID 12119297 DOI: 10.1074/jbc.M205071200  0.8
2002 Field SJ, Lamia KA, Rameh LE, Cantley LC. Lipid research picks up speed on the slopes of Taos. Developmental Cell. 2: 407-10. PMID 11970891 DOI: 10.1016/S1534-5807(02)00150-8  1
2002 Ueki K, Yballe CM, Brachmann SM, Vicent D, Watt JM, Kahn CR, Cantley LC. Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase. Proceedings of the National Academy of Sciences of the United States of America. 99: 419-24. PMID 11752399 DOI: 10.1073/pnas.012581799  1
2001 Kanai F, Liu H, Field SJ, Akbary H, Matsuo T, Brown GE, Cantley LC, Yaffe MB. The PX domains of p47phox and p40phox bind to lipid products of PI(3)K. Nature Cell Biology. 3: 675-8. PMID 11433300 DOI: 10.1038/35083070  1
2001 Yaffe MB, Leparc GG, Lai J, Obata T, Volinia S, Cantley LC. A motif-based profile scanning approach for genome-wide prediction of signaling pathways. Nature Biotechnology. 19: 348-53. PMID 11283593 DOI: 10.1038/86737  1
2000 Kanai F, Marignani PA, Sarbassova D, Yagi R, Hall RA, Donowitz M, Hisaminato A, Fujiwara T, Ito Y, Cantley LC, Yaffe MB. TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins. The Embo Journal. 19: 6778-91. PMID 11118213 DOI: 10.1093/emboj/19.24.6778  1
2000 Nishikawa K, Sawasdikosol S, Fruman DA, Lai J, Songyang Z, Burakoff SJ, Yaffe MB, Cantley LC. A peptide library approach identifies a specific inhibitor for the ZAP-70 protein tyrosine kinase. Molecular Cell. 6: 969-74. PMID 11090635  1
2000 Yaffe MB, Cantley LC. Mapping specificity determinants for protein-protein association using protein fusions and random peptide libraries. Methods in Enzymology. 328: 157-70. PMID 11075345  1
2000 Fruman DA, Mauvais-Jarvis F, Pollard DA, Yballe CM, Brazil D, Bronson RT, Kahn CR, Cantley LC. Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha. Nature Genetics. 26: 379-82. PMID 11062485 DOI: 10.1038/81715  1
2000 Obata T, Yaffe MB, Leparc GG, Piro ET, Maegawa H, Kashiwagi A, Kikkawa R, Cantley LC. Peptide and protein library screening defines optimal substrate motifs for AKT/PKB. The Journal of Biological Chemistry. 275: 36108-15. PMID 10945990 DOI: 10.1074/jbc.M005497200  1
2000 Shioi T, Kang PM, Douglas PS, Hampe J, Yballe CM, Lawitts J, Cantley LC, Izumo S. The conserved phosphoinositide 3-kinase pathway determines heart size in mice. The Embo Journal. 19: 2537-48. PMID 10835352 DOI: 10.1093/emboj/19.11.2537  1
2000 Bunnell SC, Diehn M, Yaffe MB, Findell PR, Cantley LC, Berg LJ. Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade. The Journal of Biological Chemistry. 275: 2219-30. PMID 10636929 DOI: 10.1074/jbc.275.3.2219  1
1999 Fruman DA, Snapper SB, Yballe CM, Alt FW, Cantley LC. Phosphoinositide 3-kinase knockout mice: role of p85alpha in B cell development and proliferation. Biochemical Society Transactions. 27: 624-9. PMID 10917654  1
1999 Yaffe MB, Cantley LC. Signal transduction. Grabbing phosphoproteins. Nature. 402: 30-1. PMID 10573413 DOI: 10.1038/46925  0.84
1999 Poy F, Yaffe MB, Sayos J, Saxena K, Morra M, Sumegi J, Cantley LC, Terhorst C, Eck MJ. Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition. Molecular Cell. 4: 555-61. PMID 10549287 DOI: 10.1016/S1097-2765(00)80206-3  1
1999 Aramburu J, Yaffe MB, López-Rodríguez C, Cantley LC, Hogan PG, Rao A. Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A. Science (New York, N.Y.). 285: 2129-33. PMID 10497131  0.84
1999 Rittinger K, Budman J, Xu J, Volinia S, Cantley LC, Smerdon SJ, Gamblin SJ, Yaffe MB. Structural analysis of 14-3-3 phosphopeptide complexes identifies a dual role for the nuclear export signal of 14-3-3 in ligand binding. Molecular Cell. 4: 153-66. PMID 10488331  0.84
1999 Fruman DA, Snapper SB, Yballe CM, Davidson L, Yu JY, Alt FW, Cantley LC. Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha. Science (New York, N.Y.). 283: 393-7. PMID 9888855 DOI: 10.1126/science.283.5400.393  1
1998 Parker D, Jhala US, Radhakrishnan I, Yaffe MB, Reyes C, Shulman AI, Cantley LC, Wright PE, Montminy M. Analysis of an activator:coactivator complex reveals an essential role for secondary structure in transcriptional activation. Molecular Cell. 2: 353-9. PMID 9774973 DOI: 10.1016/S1097-2765(00)80279-8  0.84
1997 Yaffe MB, Rittinger K, Volinia S, Caron PR, Aitken A, Leffers H, Gamblin SJ, Smerdon SJ, Cantley LC. The structural basis for 14-3-3:phosphopeptide binding specificity. Cell. 91: 961-71. PMID 9428519  0.84
1997 Yaffe MB, Schutkowski M, Shen M, Zhou XZ, Stukenberg PT, Rahfeld JU, Xu J, Kuang J, Kirschner MW, Fischer G, Cantley LC, Lu KP. Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism. Science (New York, N.Y.). 278: 1957-60. PMID 9395400 DOI: 10.1126/science.278.5345.1957  1
1978 Cantley LC, Resh MD, Guidotti G. Vanadate inhibits the red cell (Na+, K+) ATPase from the cytoplasmic side. Nature. 272: 552-4. PMID 211419 DOI: 10.1038/272552a0  1
1977 Cantley LC, Josephson L, Warner R, Yanagisawa M, Lechene C, Guidotti G. Vanadate is a potent (Na,K)-ATPase inhibitor found in ATP derived from muscle. The Journal of Biological Chemistry. 252: 7421-3. PMID 144127  1
1976 Cantley LC, Hammes GG. Investigation of quercetin binding sites on chloroplast coupling factor 1. Biochemistry. 15: 1-8. PMID 1247500  1
1976 Cantley LC, Hammes GG. Characterization of sulfhydryl groups on chloroplast coupling factor 1 exposed by heat activation. Biochemistry. 15: 9-14. PMID 129152  1
1975 Cantley LC, Hammes GG. Fluorescence energy transfer between ligand binding sites on chloroplast coupling factor 1. Biochemistry. 14: 2976-81. PMID 1148188  1
1975 Cantley LC, Hammes GG. Characterization of nucleotide binding sites on chloroplast coupling factor 1. Biochemistry. 14: 2968-75. PMID 1148187  1
1973 Cantley LC, Hammes GG. Activation of beef heart mitochondrial adenosine triphosphatase by 2,4-dinitrophenol. Biochemistry. 12: 4900-4. PMID 4271561  1
Low-probability matches
2020 Balasuriya N, Davey NE, Johnson JL, Liu H, Biggar KK, Cantley LC, Li SS, O'Donoghue P. Phosphorylation-dependent substrate selectivity of protein kinase B (AKT1). The Journal of Biological Chemistry. PMID 32350110 DOI: 10.1074/jbc.RA119.012425  0.28
2015 Kim JA, Im S, Cantley LC, Kim DW. Suppression of Nkx3.2 by phosphatidylinositol-3-kinase signaling regulates cartilage development by modulating chondrocyte hypertrophy. Cellular Signalling. PMID 26363466 DOI: 10.1016/j.cellsig.2015.09.004  0.28
2019 Xing Y, Lin NU, Maurer MA, Chen H, Mahvash A, Sahin A, Akcakanat A, Li Y, Abramson V, Litton J, Chavez-MacGregor M, Valero V, Piha-Paul SA, Hong D, Do KA, ... ... Cantley LC, et al. Phase II trial of AKT inhibitor MK-2206 in patients with advanced breast cancer who have tumors with PIK3CA or AKT mutations, and/or PTEN loss/PTEN mutation. Breast Cancer Research : Bcr. 21: 78. PMID 31277699 DOI: 10.1186/s13058-019-1154-8  0.24
2019 Konstantinopoulos PA, Barry WT, Birrer M, Westin SN, Cadoo KA, Shapiro GI, Mayer EL, O'Cearbhaill RE, Coleman RL, Kochupurakkal B, Whalen C, Curtis J, Farooq S, Luo W, Eismann J, ... ... Cantley LC, et al. Olaparib and α-specific PI3K inhibitor alpelisib for patients with epithelial ovarian cancer: a dose-escalation and dose-expansion phase 1b trial. The Lancet. Oncology. PMID 30880072 DOI: 10.1016/S1470-2045(18)30905-7  0.24
2019 Hodakoski C, Hopkins BD, Zhang G, Su T, Cheng Z, Morris R, Rhee KY, Goncalves MD, Cantley LC. Rac-Mediated Macropinocytosis of Extracellular Protein Promotes Glucose Independence in Non-Small Cell Lung Cancer. Cancers. 11. PMID 30609754 DOI: 10.3390/cancers11010037  0.24
2018 Browne CM, Jiang B, Ficarro SB, Doctor ZM, Johnson JL, Card JD, Sivakumaren SC, Alexander WM, Yaron T, Murphy CJ, Kwiatkowski NP, Zhang T, Cantley LC, Gray NS, Marto JA. A Chemoproteomic Strategy for Direct and Proteome-wide Covalent Inhibitor Target-site Identification. Journal of the American Chemical Society. PMID 30518210 DOI: 10.1021/jacs.8b07911  0.24
2018 Goncalves MD, Hwang SK, Pauli C, Murphy CJ, Cheng Z, Hopkins BD, Wu D, Loughran RM, Emerling BM, Zhang G, Fearon DT, Cantley LC. Fenofibrate prevents skeletal muscle loss in mice with lung cancer. Proceedings of the National Academy of Sciences of the United States of America. PMID 29311302 DOI: 10.1073/pnas.1714703115  0.24
2017 Pauli C, Hopkins BD, Prandi D, Shaw R, Fedrizzi T, Sboner A, Sailer V, Augello M, Puca L, Rosati R, McNary TJ, Churakova Y, Cheung C, Triscott J, Pisapia D, ... ... Cantley LC, et al. Personalized In Vitro and In Vivo Cancer Models to Guide Precision Medicine. Cancer Discovery. PMID 28331002 DOI: 10.1158/2159-8290.CD-16-1154  0.24
2017 de Oliveira Taveira M, Nabavi S, Wang Y, Tonellato P, Esteva FJ, Cantley LC, Wulf GM. Genomic characteristics of trastuzumab-resistant Her2-positive metastatic breast cancer. Journal of Cancer Research and Clinical Oncology. PMID 28247034 DOI: 10.1007/s00432-017-2358-x  0.24
2020 Manz TD, Sivakumaren SC, Ferguson FM, Zhang T, Yasgar A, Seo HS, Ficarro SB, Card JD, Shim H, Miduturu CV, Simeonov A, Shen M, Marto JA, Dhe-Paganon S, Hall MD, ... Cantley LC, et al. Discovery and Structure-Activity Relationship Study of (Z)-5-Methylenethiazolidin-4-one Derivatives as Potent and Selective Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors. Journal of Medicinal Chemistry. PMID 32298120 DOI: 10.1021/acs.jmedchem.0c00227  0.2
2019 Ferguson FM, Doctor ZM, Ficarro SB, Browne CM, Marto JA, Johnson JL, Yaron TM, Cantley LC, Kim ND, Sim T, Berberich MJ, Kalocsay M, Sorger PK, Gray NS. Discovery of Covalent CDK14 Inhibitors with Pan-TAIRE Family Specificity. Cell Chemical Biology. PMID 30930164 DOI: 10.1016/j.chembiol.2019.02.015  0.2
2018 Lee HS, Lin Z, Chae S, Yoo YS, Kim BG, Lee Y, Johnson JL, Kim YS, Cantley LC, Lee CW, Yu H, Cho H. The chromatin remodeler RSF1 controls centromeric histone modifications to coordinate chromosome segregation. Nature Communications. 9: 3848. PMID 30242288 DOI: 10.1038/s41467-018-06377-w  0.2
2017 Thorpe LM, Spangle JM, Ohlson CE, Cheng H, Roberts TM, Cantley LC, Zhao JJ. PI3K-p110α mediates the oncogenic activity induced by loss of the novel tumor suppressor PI3K-p85α. Proceedings of the National Academy of Sciences of the United States of America. PMID 28630349 DOI: 10.1073/pnas.1704706114  0.2
2016 Wang Y, Begley M, Li Q, Huang HT, Lako A, Eck MJ, Gray NS, Mitchison TJ, Cantley LC, Zhao JJ. Mitotic MELK-eIF4B signaling controls protein synthesis and tumor cell survival. Proceedings of the National Academy of Sciences of the United States of America. PMID 27528663 DOI: 10.1073/pnas.1606862113  0.2
2020 Goncalves MD, Cantley LC. A 'fast'er way to treat breast cancer. Nature Metabolism. 2: 559-560. PMID 32694797 DOI: 10.1038/s42255-020-0225-6  0.16
2020 Han Y, Yang L, Duan X, Duan F, Nilsson-Payant BE, Yaron TM, Wang P, Tang X, Zhang T, Zhao Z, Bram Y, Redmond D, Houghton S, Nguyen D, Xu D, ... ... Cantley LC, et al. Identification of Candidate COVID-19 Therapeutics using hPSC-derived Lung Organoids. Biorxiv : the Preprint Server For Biology. PMID 32511403 DOI: 10.1101/2020.05.05.079095  0.16
2020 Hopkins BD, Goncalves MD, Cantley LC. Insulin-PI3K signalling: an evolutionarily insulated metabolic driver of cancer. Nature Reviews. Endocrinology. PMID 32127696 DOI: 10.1038/s41574-020-0329-9  0.16
2018 Goncalves MD, Hopkins BD, Cantley LC. Phosphatidylinositol 3-Kinase, Growth Disorders, and Cancer. The New England Journal of Medicine. 379: 2052-2062. PMID 30462943 DOI: 10.1056/NEJMra1704560  0.16
2018 Hopkins BD, Pauli C, Du X, Wang DG, Li X, Wu D, Amadiume SC, Goncalves MD, Hodakoski C, Lundquist MR, Bareja R, Ma Y, Harris EM, Sboner A, Beltran H, ... ... Cantley LC, et al. Publisher Correction: Suppression of insulin feedback enhances the efficacy of PI3K inhibitors. Nature. PMID 30158705 DOI: 10.1038/s41586-018-0506-3  0.16
2018 Hopkins BD, Pauli C, Du X, Wang DG, Li X, Wu D, Amadiume SC, Goncalves MD, Hodakoski C, Lundquist MR, Bareja R, Ma Y, Harris EM, Sboner A, Beltran H, ... ... Cantley LC, et al. Suppression of insulin feedback enhances the efficacy of PI3K inhibitors. Nature. PMID 30051890 DOI: 10.1038/s41586-018-0343-4  0.16
2018 Goncalves MD, Cantley LC. A Glycolysis Outsider Steps into the Cancer Spotlight. Cell Metabolism. 28: 3-4. PMID 29972796 DOI: 10.1016/j.cmet.2018.06.017  0.16
2018 DelNero P, Hopkins BD, Cantley LC, Fischbach C. Cancer metabolism gets physical. Science Translational Medicine. 10. PMID 29794058 DOI: 10.1126/scitranslmed.aaq1011  0.16
2016 Hopkins BD, Goncalves MD, Cantley LC. Obesity and Cancer Mechanisms: Cancer Metabolism. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 34: 4277-4283. PMID 27903152 DOI: 10.1200/JCO.2016.67.9712  0.16
2015 Baselga J, Bhardwaj N, Cantley LC, DeMatteo R, DuBois RN, Foti M, Gapstur SM, Hahn WC, Helman LJ, Jensen RA, Paskett ED, Lawrence TS, Lutzker SG, Szabo E. AACR Cancer Progress Report 2015. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 21: S1-S128. PMID 26429991 DOI: 10.1158/1078-0432.CCR-15-1846  0.16
2018 Cohen SB, Bainter W, Johnson JL, Lin TY, Wong JCY, Wallace J, Jones J, Mir F, Qamar F, Cantley LC, Geha RS, Chou J. Human primary immunodeficiency caused by expression of a kinase-dead p110δ mutant. The Journal of Allergy and Clinical Immunology. PMID 30336224 DOI: 10.1016/j.jaci.2018.10.005  0.12
2017 You MH, Kim BM, Chen CH, Begley MJ, Cantley LC, Lee TH. Death-associated protein kinase 1 phosphorylates NDRG2 and induces neuronal cell death. Cell Death and Differentiation. 24: 238-250. PMID 28141794 DOI: 10.1038/cdd.2016.114  0.12
2020 Lee EK, Tan-Wasielewski Z, Aghajanian C, Coleman RL, Curtis J, Hirsch MS, Matulonis UA, Cantley LC, Mills GB, Doyle LA, Liu JF. Results of an abbreviated phase II study of AKT inhibitor MK-2206 in the treatment of recurrent platinum-resistant high grade serous ovarian, fallopian tube, or primary peritoneal carcinoma (NCT 01283035). Gynecologic Oncology Reports. 32: 100546. PMID 32083163 DOI: 10.1016/j.gore.2020.100546  0.08
2019 Stein BD, Calzolari D, Hellberg K, Hu YS, He L, Hung CM, Toyama EQ, Ross DS, Lillemeier BF, Cantley LC, Yates JR, Shaw RJ. Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks. Cell Reports. 29: 3331-3348.e7. PMID 31801093 DOI: 10.1016/j.celrep.2019.10.117  0.08
2019 Myers AP, Konstantinopoulos PA, Barry WT, Luo W, Broaddus RR, Makker V, Drapkin R, Liu J, Doyle A, Horowitz NS, Meric-Bernstam F, Birrer M, Aghajanian C, Coleman RL, Mills GB, ... Cantley LC, et al. Phase II, 2-Stage, 2-Arm, PIK3CA Mutation Stratified Trial of MK-2206 in Recurrent Endometrial Cancer. International Journal of Cancer. PMID 31714586 DOI: 10.1002/ijc.32783  0.08
2017 Croessmann S, Sheehan JH, Lee KM, Sliwoski GR, He J, Nagy RJ, Riddle DA, Mayer IA, Balko JM, Lanman RB, Miller V, Cantley LC, Meiler J, Arteaga CL. PIK3CA C2 domain deletions hyperactivate phosphoinositide 3-kinase (PI3K), generate oncogene dependence and are exquisitely sensitive to PI3Kα inhibitors. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 29284706 DOI: 10.1158/1078-0432.CCR-17-2141  0.08
2020 Robert T, Johnson JL, Guichaoua R, Yaron TM, Bach S, Cantley LC, Colas P. Development of a CDK10/CycM Kinase Screening Assay and Identification of First Small-Molecule Inhibitors. Frontiers in Chemistry. 8: 147. PMID 32175313 DOI: 10.3389/fchem.2020.00147  0.04
2019 Vasan N, Razavi P, Johnson JL, Shao H, Shah H, Antoine A, Ladewig E, Gorelick A, Lin TY, Toska E, Xu G, Kazmi A, Chang MT, Taylor BS, Dickler MN, ... ... Cantley LC, et al. Double mutations in cis increase oncogenicity and sensitivity to PI3Kα inhibitors. Science (New York, N.Y.). 366: 714-723. PMID 31699932 DOI: 10.1126/science.aaw9032  0.04
2019 Liu C, Knudsen GM, Pedley AM, He J, Johnson JL, Yaron TM, Cantley LC, Benkovic SJ. Mapping post-translational modifications of de novo purine biosynthetic enzymes: Implications for pathway regulation. Journal of Proteome Research. PMID 30964683 DOI: 10.1021/acs.jproteome.8b00969  0.04
2018 Carbone M, Amelio I, Affar EB, Brugarolas J, Cannon-Albright LA, Cantley LC, Cavenee WK, Chen Z, Croce CM, Andrea A, Gandara D, Giorgi C, Jia W, Lan Q, Mak TW, et al. Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine. Cell Death and Differentiation. PMID 30323273 DOI: 10.1038/s41418-018-0213-5  0.04
2016 Hodges TR, Ferguson SD, Caruso HG, Kohanbash G, Zhou S, Cloughesy TF, Berger MS, Poste GH, Khasraw M, Ba S, Jiang T, Mikkelson T, Yung WK, de Groot JF, Fine H, ... Cantley LC, et al. Prioritization schema for immunotherapy clinical trials in glioblastoma. Oncoimmunology. 5: e1145332. PMID 27471611 DOI: 10.1080/2162402X.2016.1145332  0.04
2020 Noch EK, Yim I, Milner TA, Cantley LC. Distribution and localization of phosphatidylinositol 5-phosphate, 4-kinase alpha and beta in the brain. The Journal of Comparative Neurology. PMID 32449185 DOI: 10.1002/cne.24956  0.01
2019 Croessmann S, Sheehan JH, Lee KM, Sliwoski G, He J, Nagy R, Riddle D, Mayer IA, Balko JM, Lanman R, Miller VA, Cantley LC, Meiler J, Arteaga CL. Correction: C2 Domain Deletions Hyperactivate Phosphoinositide 3-kinase (PI3K), Generate Oncogene Dependence, and Are Exquisitely Sensitive to PI3Kα Inhibitors. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 25: 1432. PMID 30770491 DOI: 10.1158/1078-0432.CCR-18-4269  0.01
2018 Bakhoum SF, Cantley LC. The Multifaceted Role of Chromosomal Instability in Cancer and Its Microenvironment. Cell. 174: 1347-1360. PMID 30193109 DOI: 10.1016/j.cell.2018.08.027  0.01
2016 Cantley LC. Seeking out the sweet spot in cancer therapeutics: an interview with Lewis Cantley. Disease Models & Mechanisms. 9: 911-6. PMID 27491070 DOI: 10.1242/dmm.026856  0.01
2016 Mayer IA, Abramson V, Formisano L, Balko JM, Estrada MV, Sanders M, Juric D, Solit D, Berger MF, Won H, Li Y, Cantley LC, Winer EP, Arteaga CL. A Phase Ib Study of Alpelisib (BYL719), a PI3Kα-specific Inhibitor, with Letrozole in ER+/HER2-Negative Metastatic Breast Cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 27126994 DOI: 10.1158/1078-0432.CCR-16-0134  0.01
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