| Year |
Citation |
Score |
| 2016 |
Jarvis C, Han Z, Kalas V, Klein R, Pinkner JS, Ford B, Binkley J, Cusumano CK, Cusumano Z, Mydock-McGrane L, Hultgren SJ, Janetka JW. Antivirulence Isoquinolone Mannosides: Optimization of the Biaryl Aglycone for FimH Lectin Binding Affinity and Efficacy in the Treatment of Chronic UTI. Chemmedchem. PMID 26812660 DOI: 10.1002/Cmdc.201600006 |
0.618 |
|
| 2016 |
Jarvis C, Han Z, Kalas V, Klein R, Pinkner JS, Ford B, Binkley J, Cusumano CK, Cusumano Z, Mydock-McGrane L, Hultgren SJ, Janetka JW. Cover Picture: Antivirulence Isoquinolone Mannosides: Optimization of the Biaryl Aglycone for FimH Lectin Binding Affinity and Efficacy in the Treatment of Chronic UTI (ChemMedChem 4/2016) Chemmedchem. 11: 351-351. DOI: 10.1002/Cmdc.201600045 |
0.498 |
|
| 2012 |
Guiton PS, Cusumano CK, Kline KA, Dodson KW, Han Z, Janetka JW, Henderson JP, Caparon MG, Hultgren SJ. Combinatorial small-molecule therapy prevents uropathogenic Escherichia coli catheter-associated urinary tract infections in mice. Antimicrobial Agents and Chemotherapy. 56: 4738-45. PMID 22733070 DOI: 10.1128/Aac.00447-12 |
0.649 |
|
| 2012 |
Kostakioti M, Hadjifrangiskou M, Cusumano CK, Hannan TJ, Janetka JW, Hultgren SJ. Distinguishing the contribution of type 1 pili from that of other QseB-misregulated factors when QseC is absent during urinary tract infection Infection and Immunity. 80: 2826-2834. PMID 22665375 DOI: 10.1128/Iai.00283-12 |
0.679 |
|
| 2012 |
Han Z, Pinkner JS, Ford B, Chorell E, Crowley JM, Cusumano CK, Campbell S, Henderson JP, Hultgren SJ, Janetka JW. Lead optimization studies on FimH antagonists: discovery of potent and orally bioavailable ortho-substituted biphenyl mannosides. Journal of Medicinal Chemistry. 55: 3945-59. PMID 22449031 DOI: 10.1021/Jm300165M |
0.608 |
|
| 2012 |
Chorell E, Pinkner JS, Bengtsson C, Edvinsson S, Cusumano CK, Rosenbaum E, Johansson LB, Hultgren SJ, Almqvist F. Design and synthesis of fluorescent pilicides and curlicides: bioactive tools to study bacterial virulence mechanisms. Chemistry (Weinheim An Der Bergstrasse, Germany). 18: 4522-32. PMID 22431310 DOI: 10.1002/Chem.201103936 |
0.526 |
|
| 2011 |
Cusumano CK, Pinkner JS, Han Z, Greene SE, Ford BA, Crowley JR, Henderson JP, Janetka JW, Hultgren SJ. Treatment and prevention of urinary tract infection with orally active FimH inhibitors. Science Translational Medicine. 3: 109ra115. PMID 22089451 DOI: 10.1126/Scitranslmed.3003021 |
0.653 |
|
| 2010 |
Han Z, Pinkner JS, Ford B, Obermann R, Nolan W, Wildman SA, Hobbs D, Ellenberger T, Cusumano CK, Hultgren SJ, Janetka JW. Structure-based drug design and optimization of mannoside bacterial FimH antagonists. Journal of Medicinal Chemistry. 53: 4779-92. PMID 20507142 DOI: 10.1021/Jm100438S |
0.618 |
|
| 2010 |
Cusumano CK, Hung CS, Chen SL, Hultgren SJ. Virulence plasmid harbored by uropathogenic Escherichia coli functions in acute stages of pathogenesis. Infection and Immunity. 78: 1457-67. PMID 20123719 DOI: 10.1128/Iai.01260-09 |
0.617 |
|
| 2009 |
Chen SL, Hung CS, Pinkner JS, Walker JN, Cusumano CK, Li Z, Bouckaert J, Gordon JI, Hultgren SJ. Positive selection identifies an in vivo role for FimH during urinary tract infection in addition to mannose binding. Proceedings of the National Academy of Sciences of the United States of America. 106: 22439-44. PMID 20018753 DOI: 10.1073/Pnas.0902179106 |
0.668 |
|
| 2009 |
Cegelski L, Pinkner JS, Hammer ND, Cusumano CK, Hung CS, Chorell E, Aberg V, Walker JN, Seed PC, Almqvist F, Chapman MR, Hultgren SJ. Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation. Nature Chemical Biology. 5: 913-9. PMID 19915538 DOI: 10.1038/Nchembio.242 |
0.669 |
|
| 2009 |
Cusumano CK, Hultgren SJ. Bacterial adhesion--a source of alternate antibiotic targets. Idrugs : the Investigational Drugs Journal. 12: 699-705. PMID 19844856 |
0.521 |
|
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