Michael C. Edler, Ph.D. - Publications

Affiliations: 
2003 University of Utah, Salt Lake City, UT 
Area:
Pharmacology, Toxicology

16 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2010 Kong Y, Wang K, Edler MC, Hamel E, Mooberry SL, Paige MA, Brown ML. A boronic acid chalcone analog of combretastatin A-4 as a potent anti-proliferation agent. Bioorganic & Medicinal Chemistry. 18: 971-7. PMID 20006519 DOI: 10.1016/J.Bmc.2009.11.003  0.36
2009 La Regina G, Sarkar T, Bai R, Edler MC, Saletti R, Coluccia A, Piscitelli F, Minelli L, Gatti V, Mazzoccoli C, Palermo V, Mazzoni C, Falcone C, Scovassi AI, Giansanti V, et al. New arylthioindoles and related bioisosteres at the sulfur bridging group. 4. Synthesis, tubulin polymerization, cell growth inhibition, and molecular modeling studies Journal of Medicinal Chemistry. 52: 7512-7527. PMID 19601594 DOI: 10.1021/jm900016t  0.36
2009 Edler MC, Yang G, Katherine Jung M, Bai R, Bornmann WG, Hamel E. Demonstration of microtubule-like structures formed with (-)-rhazinilam from purified tubulin outside of cells and a simple tubulin-based assay for evaluation of analog activity Archives of Biochemistry and Biophysics. 487: 98-104. PMID 19497297 DOI: 10.1016/j.abb.2009.05.014  0.36
2009 Bai R, Edler MC, Bonate PL, Copeland TD, Pettit GR, Ludueña RF, Hamel E. Intracellular activation and deactivation of tasidotin, an analog of dolastatin 15: correlation with cytotoxicity. Molecular Pharmacology. 75: 218-26. PMID 18927208 DOI: 10.1124/Mol.108.051110  0.36
2007 Shin Y, Fournier JH, Brückner A, Madiraju C, Balachandran R, Raccor BS, Edler MC, Hamel E, Sikorski RP, Vogt A, Day BW, Curran DP. Synthesis and biological evaluation of (-)-dictyostatin and stereoisomers. Tetrahedron. 63: 8537-8562. PMID 18728696 DOI: 10.1016/J.Tet.2007.05.033  0.36
2007 La Regina G, Edler MC, Brancale A, Kandil S, Coluccia A, Piscitelli F, Hamel E, De Martino G, Matesanz R, Díaz JF, Scovassi AI, Prosperi E, Lavecchia A, Novellino E, Artico M, et al. Arylthioindole inhibitors of tubulin polymerization. 3. Biological evaluation, structure-activity relationships and molecular modeling studies. Journal of Medicinal Chemistry. 50: 2865-74. PMID 17497841 DOI: 10.1021/Jm061479U  0.36
2007 Buey RM, Calvo E, Barasoain I, Pineda O, Edler MC, Matesanz R, Cerezo G, Vanderwal CD, Day BW, Sorensen EJ, López JA, Andreu JM, Hamel E, Díaz JF. Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites. Nature Chemical Biology. 3: 117-25. PMID 17206139 DOI: 10.1038/Nchembio853  0.36
2006 De Martino G, Edler MC, La Regina G, Coluccia A, Barbera MC, Barrow D, Nicholson RI, Chiosis G, Brancale A, Hamel E, Artico M, Silvestri R. New arylthioindoles: potent inhibitors of tubulin polymerization. 2. Structure-activity relationships and molecular modeling studies. Journal of Medicinal Chemistry. 49: 947-54. PMID 16451061 DOI: 10.1021/Jm050809S  0.36
2005 Madiraju C, Edler MC, Hamel E, Raccor BS, Balachandran R, Zhu G, Giuliano KA, Vogt A, Shin Y, Fournier JH, Fukui Y, Brückner AM, Curran DP, Day BW. Tubulin assembly, taxoid site binding, and cellular effects of the microtubule-stabilizing agent dictyostatin. Biochemistry. 44: 15053-63. PMID 16274252 DOI: 10.1021/Bi050685L  0.36
2005 Kong Y, Grembecka J, Edler MC, Hamel E, Mooberry SL, Sabat M, Rieger J, Brown ML. Structure-based discovery of a boronic acid bioisostere of combretastatin A-4. Chemistry & Biology. 12: 1007-14. PMID 16183025 DOI: 10.1016/J.Chembiol.2005.06.016  0.36
2005 Edler MC, Buey RM, Gussio R, Marcus AI, Vanderwal CD, Sorensen EJ, Díaz JF, Giannakakou P, Hamel E. Cyclostreptin (FR182877), an antitumor tubulin-polymerizing agent deficient in enhancing tubulin assembly despite its high affinity for the taxoid site. Biochemistry. 44: 11525-38. PMID 16114889 DOI: 10.1021/Bi050660M  0.36
2005 Shin Y, Fournier JH, Balachandran R, Madiraju C, Raccor BS, Zhu G, Edler MC, Hamel E, Day BW, Curran DP. Synthesis and biological evaluation of (-)-16-normethyldictyostatin: a potent analogue of (-)-dictyostatin. Organic Letters. 7: 2873-6. PMID 15987158 DOI: 10.1021/Ol050808U  0.36
2004 De Martino G, La Regina G, Coluccia A, Edler MC, Barbera MC, Brancale A, Wilcox E, Hamel E, Artico M, Silvestri R. Arylthioindoles, potent inhibitors of tubulin polymerization. Journal of Medicinal Chemistry. 47: 6120-3. PMID 15566282 DOI: 10.1021/Jm049360D  0.36
2004 Raffa D, Edler MC, Daidone G, Maggio B, Merikech M, Merickech M, Plescia S, Schillaci D, Bai R, Hamel E. Synthesis, cytotoxicity, and inhibitory effects on tubulin polymerization of a new 3-heterocyclo substituted 2-styrylquinazolinones. European Journal of Medicinal Chemistry. 39: 299-304. PMID 15072839 DOI: 10.1016/J.Ejmech.2003.12.009  0.36
2003 Chevallier C, Richardson AD, Edler MC, Hamel E, Harper MK, Ireland CM. A new cytotoxic and tubulin-interactive milnamide derivative from a marine sponge Cymbastela sp. Organic Letters. 5: 3737-9. PMID 14507218 DOI: 10.1021/Ol035476C  0.36
2002 Edler MC, Fernandez AM, Lassota P, Ireland CM, Barrows LR. Inhibition of tubulin polymerization by vitilevuamide, a bicyclic marine peptide, at a site distinct from colchicine, the vinca alkaloids, and dolastatin 10. Biochemical Pharmacology. 63: 707-15. PMID 11992639 DOI: 10.1016/S0006-2952(01)00898-X  0.36
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