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Astrid M. Kral, Ph.D. - Publications

Affiliations: 
2000 University of Pennsylvania, Philadelphia, PA, United States 
Area:
Biochemistry
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29 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Kopinja J, Sevilla RS, Levitan D, Dai D, Vanko A, Spooner E, Ware C, Forget R, Hu K, Kral A, Spacciapoli P, Kennan R, Jayaraman L, Pucci V, Perera S, et al. A Brain Penetrant Mutant IDH1 Inhibitor Provides In Vivo Survival Benefit. Scientific Reports. 7: 13853. PMID 29062039 DOI: 10.1038/S41598-017-14065-W  0.335
2016 O'Neil J, Benita Y, Feldman I, Chenard M, Roberts B, Liu Y, Li J, Kral A, Lejnine S, Loboda A, Arthur W, Cristescu R, Haines BB, Winter C, Zhang T, et al. An unbiased oncology compound screen to identify novel combination strategies. Molecular Cancer Therapeutics. PMID 26983881 DOI: 10.1158/1535-7163.Mct-15-0843  0.34
2014 Methot JL, Hoffman DM, Witter DJ, Stanton MG, Harrington P, Hamblett C, Siliphaivanh P, Wilson K, Hubbs J, Heidebrecht R, Kral AM, Ozerova N, Fleming JC, Wang H, Szewczak AA, et al. Delayed and Prolonged Histone Hyperacetylation with a Selective HDAC1/HDAC2 Inhibitor. Acs Medicinal Chemistry Letters. 5: 340-5. PMID 24900838 DOI: 10.1021/Ml4004233  0.4
2014 Kral AM, Ozerova N, Close J, Jung J, Chenard M, Fleming J, Haines BB, Harrington P, Maclean J, Miller TA, Secrist P, Wang H, Heidebrecht RW. Divergent kinetics differentiate the mechanism of action of two HDAC inhibitors. Biochemistry. 53: 725-34. PMID 24450491 DOI: 10.1021/Bi400936H  0.404
2013 Newbold A, Matthews GM, Bots M, Cluse LA, Clarke CJ, Banks KM, Cullinane C, Bolden JE, Christiansen AJ, Dickins RA, Miccolo C, Chiocca S, Kral AM, Ozerova ND, Miller TA, et al. Molecular and biologic analysis of histone deacetylase inhibitors with diverse specificities. Molecular Cancer Therapeutics. 12: 2709-21. PMID 24092806 DOI: 10.1158/1535-7163.Mct-13-0626  0.398
2010 Methot JL, Chenard M, Joshua C, Jonathan C, Dahlberg W, Fleming J, Hamblett C, Julie H, Harrington P, Harsch A, Heidebrecht R, Hughes B, Jung J, Kenific C, Kral A, et al. Abstract 5433: Prolonged histone hyperacetylation with a novel class of HDAC1/2 selective inhibitors Cancer Research. 70: 5433-5433. DOI: 10.1158/1538-7445.Am10-5433  0.404
2009 Heidebrecht RW, Chenard M, Close J, Dahlberg WK, Fleming J, Grimm JB, Hamill JE, Harsch A, Haines BB, Hughes B, Kral AM, Middleton RE, Mushti C, Ozerova N, Szewczak AA, et al. Exploring the pharmacokinetic properties of phosphorus-containing selective HDAC 1 and 2 inhibitors (SHI-1:2). Bioorganic & Medicinal Chemistry Letters. 19: 2053-8. PMID 19268585 DOI: 10.1016/J.Bmcl.2009.02.009  0.393
2009 Kattar SD, Surdi LM, Zabierek A, Methot JL, Middleton RE, Hughes B, Szewczak AA, Dahlberg WK, Kral AM, Ozerova N, Fleming JC, Wang H, Secrist P, Harsch A, Hamill JE, et al. Parallel medicinal chemistry approaches to selective HDAC1/HDAC2 inhibitor (SHI-1:2) optimization. Bioorganic & Medicinal Chemistry Letters. 19: 1168-72. PMID 19138845 DOI: 10.1016/J.Bmcl.2008.12.083  0.334
2008 Lee AY, Paweletz CP, Pollock RM, Settlage RE, Cruz JC, Secrist JP, Miller TA, Stanton MG, Kral AM, Ozerova ND, Meng F, Yates NA, Richon V, Hendrickson RC. Quantitative analysis of histone deacetylase-1 selective histone modifications by differential mass spectrometry. Journal of Proteome Research. 7: 5177-86. PMID 19367703 DOI: 10.1021/Pr800510P  0.382
2008 Methot JL, Hamblett CL, Mampreian DM, Jung J, Harsch A, Szewczak AA, Dahlberg WK, Middleton RE, Hughes B, Fleming JC, Wang H, Kral AM, Ozerova N, Cruz JC, Haines B, et al. SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2). Bioorganic & Medicinal Chemistry Letters. 18: 6104-9. PMID 18951790 DOI: 10.1016/J.Bmcl.2008.10.052  0.386
2008 Wilson KJ, Witter DJ, Grimm JB, Siliphaivanh P, Otte KM, Kral AM, Fleming JC, Harsch A, Hamill JE, Cruz JC, Chenard M, Szewczak AA, Middleton RE, Hughes BL, Dahlberg WK, et al. Phenylglycine and phenylalanine derivatives as potent and selective HDAC1 inhibitors (SHI-1). Bioorganic & Medicinal Chemistry Letters. 18: 1859-63. PMID 18304810 DOI: 10.1016/J.Bmcl.2008.02.012  0.318
2008 Wu Z, Robinson RG, Fu S, Barnett SF, Defeo-Jones D, Jones RE, Kral AM, Huber HE, Kohl NE, Hartman GD, Bilodeau MT. Rapid assembly of diverse and potent allosteric Akt inhibitors. Bioorganic & Medicinal Chemistry Letters. 18: 2211-4. PMID 18296048 DOI: 10.1016/J.Bmcl.2007.10.023  0.358
2008 Hartnett JC, Barnett SF, Bilodeau MT, Defeo-Jones D, Hartman GD, Huber HE, Jones RE, Kral AM, Robinson RG, Wu Z. Optimization of 2,3,5-trisubstituted pyridine derivatives as potent allosteric Akt1 and Akt2 inhibitors. Bioorganic & Medicinal Chemistry Letters. 18: 2194-7. PMID 18294842 DOI: 10.1016/J.Bmcl.2007.12.040  0.35
2008 Wu Z, Hartnett JC, Neilson LA, Robinson RG, Fu S, Barnett SF, Defeo-Jones D, Jones RE, Kral AM, Huber HE, Hartman GD, Bilodeau MT. Development of pyridopyrimidines as potent Akt1/2 inhibitors. Bioorganic & Medicinal Chemistry Letters. 18: 1274-9. PMID 18249537 DOI: 10.1016/J.Bmcl.2008.01.054  0.324
2008 Methot JL, Chakravarty PK, Chenard M, Close J, Cruz JC, Dahlberg WK, Fleming J, Hamblett CL, Hamill JE, Harrington P, Harsch A, Heidebrecht R, Hughes B, Jung J, Kenific CM, ... Kral AM, et al. Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2). Bioorganic & Medicinal Chemistry Letters. 18: 973-8. PMID 18182289 DOI: 10.1016/J.Bmcl.2007.12.031  0.375
2008 Witter DJ, Harrington P, Wilson KJ, Chenard M, Fleming JC, Haines B, Kral AM, Secrist JP, Miller TA. Optimization of biaryl Selective HDAC1&2 Inhibitors (SHI-1:2). Bioorganic & Medicinal Chemistry Letters. 18: 726-31. PMID 18060775 DOI: 10.1016/J.Bmcl.2007.11.047  0.394
2008 Hubbs JL, Zhou H, Kral AM, Fleming JC, Dahlberg WK, Hughes BL, Middleton RE, Szewczak AA, Secrist JP, Miller TA. Amino acid derivatives as histone deacetylase inhibitors. Bioorganic & Medicinal Chemistry Letters. 18: 34-8. PMID 18042381 DOI: 10.1016/J.Bmcl.2007.11.017  0.398
2007 Hamblett CL, Methot JL, Mampreian DM, Sloman DL, Stanton MG, Kral AM, Fleming JC, Cruz JC, Chenard M, Ozerova N, Hitz AM, Wang H, Deshmukh SV, Nazef N, Harsch A, et al. The discovery of 6-amino nicotinamides as potent and selective histone deacetylase inhibitors. Bioorganic & Medicinal Chemistry Letters. 17: 5300-9. PMID 17761416 DOI: 10.1016/J.Bmcl.2007.08.023  0.385
2007 Siliphaivanh P, Harrington P, Witter DJ, Otte K, Tempest P, Kattar S, Kral AM, Fleming JC, Deshmukh SV, Harsch A, Secrist PJ, Miller TA. Design of novel histone deacetylase inhibitors. Bioorganic & Medicinal Chemistry Letters. 17: 4619-24. PMID 17555962 DOI: 10.1016/J.Bmcl.2007.05.080  0.381
2005 Barnett SF, Defeo-Jones D, Fu S, Hancock PJ, Haskell KM, Jones RE, Kahana JA, Kral AM, Leander K, Lee LL, Malinowski J, McAvoy EM, Nahas DD, Robinson RG, Huber HE. Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors. The Biochemical Journal. 385: 399-408. PMID 15456405 DOI: 10.1042/Bj20041140  0.366
2001 Lobell RB, Omer CA, Abrams MT, Bhimnathwala HG, Brucker MJ, Buser CA, Davide JP, deSolms SJ, Dinsmore CJ, Ellis-Hutchings MS, Kral AM, Liu D, Lumma WC, Machotka SV, Rands E, et al. Evaluation of farnesyl:protein transferase and geranylgeranyl:protein transferase inhibitor combinations in preclinical models. Cancer Research. 61: 8758-68. PMID 11751396  0.626
2001 Long SB, Hancock PJ, Kral AM, Hellinga HW, Beese LS. The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics. Proceedings of the National Academy of Sciences of the United States of America. 98: 12948-53. PMID 11687658 DOI: 10.1073/Pnas.241407898  0.452
2000 Omer CA, Chen Z, Diehl RE, Conner MW, Chen HY, Trumbauer ME, Gopal-Truter S, Seeburger G, Bhimnathwala H, Abrams MT, Davide JP, Ellis MS, Gibbs JB, Greenberg I, Koblan KS, ... Kral AM, et al. Mouse mammary tumor virus-Ki-rasB transgenic mice develop mammary carcinomas that can be growth-inhibited by a farnesyl:protein transferase inhibitor. Cancer Research. 60: 2680-8. PMID 10825141  0.626
1999 Omer CA, Miller PJ, Diehl RE, Kral AM. Identification of Tcf4 residues involved in high-affinity beta-catenin binding. Biochemical and Biophysical Research Communications. 256: 584-90. PMID 10080941 DOI: 10.1006/Bbrc.1999.0379  0.61
1997 Kral AM, Diehl RE, deSolms SJ, Williams TM, Kohl NE, Omer CA. Mutational analysis of conserved residues of the beta-subunit of human farnesyl:protein transferase. The Journal of Biological Chemistry. 272: 27319-23. PMID 9341181 DOI: 10.1074/Jbc.272.43.27319  0.638
1996 Williams TM, Ciccarone TM, MacTough SC, Bock RL, Conner MW, Davide JP, Hamilton K, Koblan KS, Kohl NE, Kral AM, Mosser SD, Omer CA, Pompliano DL, Rands E, Schaber MD, et al. 2-substituted piperazines as constrained amino acids. Application to the synthesis of potent, non carboxylic acid inhibitors of farnesyltransferase. Journal of Medicinal Chemistry. 39: 1345-8. PMID 8691462 DOI: 10.1021/Jm9508090  0.598
1995 Kohl NE, Omer CA, Davide JP, Hamilton K, Koblan KS, Kral AM, Miller PJ, Mosser SD, O'neill TJ, Rands E, Schaber MD, Gibbs JB, Oliff A, Conner MW, Anthony NJ, et al. Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice Nature Medicine. 1: 792-797. PMID 7585182 DOI: 10.1038/nm0895-792  0.618
1995 Omer CA, Diehl RE, Kral AM. Bacterial expression and purification of human protein prenyltransferases using epitope-tagged, translationally coupled systems. Methods in Enzymology. 250: 3-12. PMID 7544423 DOI: 10.1016/0076-6879(95)50057-X  0.609
1993 Omer CA, Kral AM, Diehl RE, Prendergast GC, Powers S, Allen CM, Gibbs JB, Kohl NE. Characterization of recombinant human farnesyl-protein transferase: cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases. Biochemistry. 32: 5167-76. PMID 8494894 DOI: 10.1021/Bi00070A028  0.632
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