Kenneth M. Humphries, Ph.D. - Publications

2000 Case Western Reserve University School of Medicine, Cleveland, OH, United States 
Biochemistry, General Biophysics, Molecular Biology

42 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Zhu S, Batushansky A, Jopkiewicz A, Makosa D, Humphries KM, Van Remmen H, Griffin TM. Sirt5 Deficiency Causes Posttranslational Protein Malonylation and Dysregulated Cellular Metabolism in Chondrocytes Under Obesity Conditions. Cartilage. 1947603521993209. PMID 33567897 DOI: 10.1177/1947603521993209  0.36
2020 Eyster CA, Matsuzaki S, Newhardt MF, Giorgione JR, Humphries KM. Diabetes induced decreases in PKA signaling in cardiomyocytes: The role of insulin. Plos One. 15: e0231806. PMID 32817622 DOI: 10.1371/journal.pone.0231806  0.44
2019 Newhardt MF, Batushansky A, Matsuzaki S, Young ZT, West M, Chin NC, Szweda LI, Kinter M, Humphries KM. Enhancing cardiac glycolysis causes an increase in PDK4 content in response to short term high fat diet. The Journal of Biological Chemistry. PMID 31562244 DOI: 10.1074/jbc.RA119.010371  0.96
2019 Batushansky A, Lopes EBP, Zhu S, Humphries KM, Griffin TM. GC-MS Method for Metabolic Profiling of Mouse Femoral Head Articular Cartilage Reveals Distinct Effects of Tissue Culture and Development. Osteoarthritis and Cartilage. PMID 31136803 DOI: 10.1016/j.joca.2019.05.010  0.36
2019 Batushansky A, Matsuzaki S, Newhardt MF, West MS, Griffin TM, Humphries KM. GC-MS metabolic profiling reveals fructose-2,6-bisphosphate regulates branched chain amino acid metabolism in the heart during fasting. Metabolomics : Official Journal of the Metabolomic Society. 15: 18. PMID 30830475 DOI: 10.1007/s11306-019-1478-5  0.44
2019 Pearsall EA, Cheng R, Matsuzaki S, Zhou K, Ding L, Ahn B, Kinter M, Humphries KM, Quiambao AB, Farjo RA, Ma JX. Neuroprotective effects of PPARα in retinopathy of type 1 diabetes. Plos One. 14: e0208399. PMID 30716067 DOI: 10.1371/journal.pone.0208399  0.6
2019 Ahn B, Ranjit R, Premkumar P, Pharaoh G, Piekarz KM, Matsuzaki S, Claflin DR, Riddle K, Judge J, Bhaskaran S, Satara Natarajan K, Barboza E, Wronowski B, Kinter M, Humphries KM, et al. Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fibre branching. Journal of Cachexia, Sarcopenia and Muscle. PMID 30706998 DOI: 10.1002/jcsm.12375  0.6
2018 Bhaskaran S, Pharaoh G, Ranjit R, Murphy A, Matsuzaki S, Nair BC, Forbes B, Gispert S, Auburger G, Humphries KM, Kinter M, Griffin TM, Deepa SS. Loss of mitochondrial protease ClpP protects mice from diet-induced obesity and insulin resistance. Embo Reports. PMID 29420235 DOI: 10.15252/embr.201745009  0.6
2018 Logan S, Pharaoh GA, Marlin MC, Masser DR, Matsuzaki S, Wronowski B, Yeganeh A, Parks EE, Premkumar P, Farley JA, Owen DB, Humphries KM, Kinter M, Freeman WM, Szweda LI, et al. Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes. Molecular Metabolism. PMID 29398615 DOI: 10.1016/j.molmet.2018.01.013  0.96
2017 Bockus LB, Matsuzaki S, Vadvalkar SS, Young ZT, Giorgione JR, Newhardt MF, Kinter M, Humphries KM. Cardiac Insulin Signaling Regulates Glycolysis Through Phosphofructokinase 2 Content and Activity. Journal of the American Heart Association. 6. PMID 29203581 DOI: 10.1161/JAHA.117.007159  0.6
2017 Pearsall EA, Cheng R, Zhou K, Takahashi Y, Matlock HG, Vadvalkar SS, Shin Y, Fredrick TW, Gantner ML, Meng S, Fu Z, Gong Y, Kinter M, Humphries KM, Szweda LI, et al. PPARα is essential for retinal lipid metabolism and neuronal survival. Bmc Biology. 15: 113. PMID 29183319 DOI: 10.1186/s12915-017-0451-x  0.96
2017 Vadvalkar SS, Matsuzaki S, Eyster CA, Giorgione JR, Bockus LB, Kinter CS, Kinter M, Humphries KM. Decreased Mitochondrial Pyruvate Transport Activity in the Diabetic Heart: Role of MPC2 Acetylation. The Journal of Biological Chemistry. PMID 28154187 DOI: 10.1074/jbc.M116.753509  0.6
2016 Bastian A, Matsuzaki S, Humphries KM, Pharaoh GA, Doshi A, Zaware N, Gangjee A, Ihnat MA. AG311, a small molecule inhibitor of complex I and hypoxia-induced HIF-1α stabilization. Cancer Letters. PMID 27939695 DOI: 10.1016/j.canlet.2016.11.040  0.44
2016 Gurley JM, Ilkayeva O, Jackson RM, Griesel BA, White P, Matsuzaki S, Qaisar R, Van Remmen H, Humphries KM, Newgard CB, Olson AL. Enhanced GLUT4-Dependent Glucose Transport Relieves Nutrient Stress in Obese Mice Through Changes in Lipid and Amino Acid Metabolism. Diabetes. PMID 27679559 DOI: 10.2337/db16-0709  0.44
2016 Fu Y, Kinter M, Hudson J, Humphries KM, Lane RS, White JR, Hakim M, Pan Y, Verdin E, Griffin TM. Aging Promotes SIRT3-dependent Cartilage SOD2 Acetylation and Osteoarthritis. Arthritis & Rheumatology (Hoboken, N.J.). PMID 26866626 DOI: 10.1002/art.39618  0.96
2015 Griffin TM, Humphries KM, Kinter M, Lim HY, Szweda LI. Nutrient sensing and utilization: Getting to the heart of metabolic flexibility. Biochimie. PMID 26476002 DOI: 10.1016/j.biochi.2015.10.013  0.96
2015 Bockus LB, Humphries KM. cAMP-dependent Protein Kinase (PKA) Signaling Is Impaired in the Diabetic Heart. The Journal of Biological Chemistry. 290: 29250-8. PMID 26468277 DOI: 10.1074/jbc.M115.681767  0.96
2015 Fernandes J, Weddle A, Kinter CS, Humphries KM, Mather T, Szweda LI, Kinter M. Lysine Acetylation Activates Mitochondrial Aconitase in the Heart. Biochemistry. 54: 4008-18. PMID 26061789 DOI: 10.1021/acs.biochem.5b00375  0.96
2015 Lane RS, Fu Y, Matsuzaki S, Kinter M, Humphries KM, Griffin TM. Mitochondrial respiration and redox coupling in articular chondrocytes. Arthritis Research & Therapy. 17: 54. PMID 25889867 DOI: 10.1186/s13075-015-0566-9  0.96
2015 Bastian A, Thorpe JE, Disch BC, Bailey-Downs LC, Gangjee A, Devambatla RK, Henthorn J, Humphries KM, Vadvalkar SS, Ihnat MA. A small molecule with anticancer and antimetastatic activities induces rapid mitochondrial-associated necrosis in breast cancer. The Journal of Pharmacology and Experimental Therapeutics. 353: 392-404. PMID 25720766 DOI: 10.1124/jpet.114.220335  0.96
2015 Matsuzaki S, Humphries KM. Selective inhibition of deactivated mitochondrial complex I by biguanides. Biochemistry. 54: 2011-21. PMID 25719498 DOI: 10.1021/bi501473h  0.96
2015 Fernandes J, Weddle A, Kinter CS, Humphries KM, Mather T, Szweda LI, Kinter M. Lysine Acetylation Activates Mitochondrial Aconitase in the Heart Biochemistry. 54: 4008-4018. DOI: 10.1021/acs.biochem.5b00375  0.96
2014 Ding L, Cheng R, Hu Y, Takahashi Y, Jenkins AJ, Keech AC, Humphries KM, Gu X, Elliott MH, Xia X, Ma JX. Peroxisome proliferator-activated receptor α protects capillary pericytes in the retina. The American Journal of Pathology. 184: 2709-20. PMID 25108226 DOI: 10.1016/j.ajpath.2014.06.021  0.96
2013 Vadvalkar SS, Baily CN, Matsuzaki S, West M, Tesiram YA, Humphries KM. Metabolic inflexibility and protein lysine acetylation in heart mitochondria of a chronic model of type 1 diabetes. The Biochemical Journal. 449: 253-61. PMID 23030792 DOI: 10.1042/BJ20121038  0.96
2012 Aurora AB, Mahmoud AI, Luo X, Johnson BA, van Rooij E, Matsuzaki S, Humphries KM, Hill JA, Bassel-Duby R, Sadek HA, Olson EN. MicroRNA-214 protects the mouse heart from ischemic injury by controlling Ca²⁺ overload and cell death. The Journal of Clinical Investigation. 122: 1222-32. PMID 22426211 DOI: 10.1172/JCI59327  0.96
2011 Matsuzaki S, Kotake Y, Humphries KM. Identification of mitochondrial electron transport chain-mediated NADH radical formation by EPR spin-trapping techniques. Biochemistry. 50: 10792-803. PMID 22091587 DOI: 10.1021/bi201714w  0.96
2011 Baily CN, Cason RW, Vadvalkar SS, Matsuzaki S, Humphries KM. Inhibition of mitochondrial respiration by phosphoenolpyruvate. Archives of Biochemistry and Biophysics. 514: 68-74. PMID 21867675 DOI: 10.1016/  0.96
2009 Matsuzaki S, Szweda PA, Szweda LI, Humphries KM. Regulated production of free radicals by the mitochondrial electron transport chain: Cardiac ischemic preconditioning. Advanced Drug Delivery Reviews. 61: 1324-31. PMID 19716389 DOI: 10.1016/j.addr.2009.05.008  0.96
2009 Moser MD, Matsuzaki S, Humphries KM. Inhibition of succinate-linked respiration and complex II activity by hydrogen peroxide. Archives of Biochemistry and Biophysics. 488: 69-75. PMID 19540189 DOI: 10.1016/  0.96
2009 Matsuzaki S, Szweda LI, Humphries KM. Mitochondrial superoxide production and respiratory activity: biphasic response to ischemic duration. Archives of Biochemistry and Biophysics. 484: 87-93. PMID 19467633 DOI: 10.1016/  0.96
2008 Montgomery RL, Potthoff MJ, Haberland M, Qi X, Matsuzaki S, Humphries KM, Richardson JA, Bassel-Duby R, Olson EN. Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice Journal of Clinical Investigation. 118: 3588-3597. PMID 18830415 DOI: 10.1172/JCI35847  0.96
2008 Applegate MA, Humphries KM, Szweda LI. Reversible inhibition of alpha-ketoglutarate dehydrogenase by hydrogen peroxide: glutathionylation and protection of lipoic acid. Biochemistry. 47: 473-8. PMID 18081316 DOI: 10.1021/bi7017464  0.96
2007 Humphries KM, Pennypacker JK, Taylor SS. Redox regulation of cAMP-dependent protein kinase signaling: kinase versus phosphatase inactivation. The Journal of Biological Chemistry. 282: 22072-9. PMID 17548350 DOI: 10.1074/jbc.M702582200  0.96
2006 Humphries KM, Szweda PA, Szweda LI. Aging: a shift from redox regulation to oxidative damage. Free Radical Research. 40: 1239-43. PMID 17090412 DOI: 10.1080/10715760600913184  0.96
2005 Humphries KM, Deal MS, Taylor SS. Enhanced dephosphorylation of cAMP-dependent protein kinase by oxidation and thiol modification. The Journal of Biological Chemistry. 280: 2750-8. PMID 15533936 DOI: 10.1074/jbc.M410242200  0.96
2002 Sadek HA, Humphries KM, Szweda PA, Szweda LI. Selective inactivation of redox-sensitive mitochondrial enzymes during cardiac reperfusion. Archives of Biochemistry and Biophysics. 406: 222-8. PMID 12361710 DOI: 10.1016/S0003-9861(02)00446-0  0.96
2002 Humphries KM, Juliano C, Taylor SS. Regulation of cAMP-dependent protein kinase activity by glutathionylation. The Journal of Biological Chemistry. 277: 43505-11. PMID 12189155 DOI: 10.1074/jbc.M207088200  0.96
2001 Bulteau AL, Lundberg KC, Humphries KM, Sadek HA, Szweda PA, Friguet B, Szweda LI. Oxidative modification and inactivation of the proteasome during coronary occlusion/reperfusion. The Journal of Biological Chemistry. 276: 30057-63. PMID 11375979 DOI: 10.1074/jbc.M100142200  0.96
2000 Sasaki M, Ansari A, Pumford N, van de Water J, Leung PS, Humphries KM, Szweda LI, Nakanuma Y, Roche TE, Coppel RL, Bach JF, Gershwin ME. Comparative immunoreactivity of anti-trifluoroacetyl (TFA) antibody and anti-lipoic acid antibody in primary biliary cirrhosis: searching for a mimic. Journal of Autoimmunity. 15: 51-60. PMID 10936028 DOI: 10.1006/jaut.2000.0390  0.96
1998 Humphries KM, Szweda LI. Selective inactivation of alpha-ketoglutarate dehydrogenase and pyruvate dehydrogenase: reaction of lipoic acid with 4-hydroxy-2-nonenal. Biochemistry. 37: 15835-41. PMID 9843389 DOI: 10.1021/bi981512h  0.96
1998 Humphries KM, Yoo Y, Szweda LI. Inhibition of NADH-linked mitochondrial respiration by 4-hydroxy-2-nonenal. Biochemistry. 37: 552-7. PMID 9425076 DOI: 10.1021/bi971958i  0.96
1997 Humphries KM, Szweda LI. 4-hydroxy-2-nonenal mediated declines in mitochondrial respiration Faseb Journal. 11.  0.96
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