Kenneth M. Humphries, Ph.D. - Related publications

2000 Case Western Reserve University School of Medicine, Cleveland, OH, United States 
Biochemistry, General Biophysics, Molecular Biology
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50 most relevant papers in past 60 days:
Year Citation  Score
2019 Hunter CA, Kartal F, Koc ZC, Murphy T, Kim JH, Denvir J, Koc EC. Mitochondrial oxidative phosphorylation is impaired in TALLYHO mice, a new obesity and type 2 diabetes animal model. The International Journal of Biochemistry & Cell Biology. 105616. PMID 31542429 DOI: 10.1016/j.biocel.2019.105616   
2019 Roussel D, Boël M, Mortz M, Romestaing C, Duchamp C, Voituron Y. Threshold effect in the HO production of skeletal muscle mitochondria during fasting and refeeding. The Journal of Experimental Biology. 222. PMID 30679239 DOI: 10.1242/jeb.196188   
2019 Alnahdi A, John A, Raza H. Augmentation of Glucotoxicity, Oxidative Stress, Apoptosis and Mitochondrial Dysfunction in HepG2 Cells by Palmitic Acid. Nutrients. 11. PMID 31443411 DOI: 10.3390/nu11091979   
2019 Fontes A, Alemany-Pagès M, Oliveira PJ, Ramalho-Santos J, Zischka H, Azul AM. Antioxidant Versus Pro-Apoptotic Effects of Mushroom-Enriched Diets on Mitochondria in Liver Disease. International Journal of Molecular Sciences. 20. PMID 31426291 DOI: 10.3390/ijms20163987   
2019 Wu M, Liao L, Jiang L, Zhang C, Gao H, Qiao L, Liu S, Shi D. Liver-targeted Nano-MitoPBN normalizes glucose metabolism by improving mitochondrial redox balance. Biomaterials. 222: 119457. PMID 31476661 DOI: 10.1016/j.biomaterials.2019.119457   
2019 Newhardt MF, Batushansky A, Matsuzaki S, Young ZT, West M, Chin NC, Szweda LI, Kinter M, Humphries KM. Enhancing cardiac glycolysis causes an increase in PDK4 content in response to short term high fat diet. The Journal of Biological Chemistry. PMID 31562244 DOI: 10.1074/jbc.RA119.010371   
2019 Wang X, Li S, Liu L, Jian Z, Cui T, Yang Y, Guo S, Yi X, Wang G, Li C, Gao T, Li K. Role of the aryl hydrocarbon receptor signaling pathway in promoting mitochondrial biogenesis against oxidative damage in human melanocytes. Journal of Dermatological Science. PMID 31543430 DOI: 10.1016/j.jdermsci.2019.09.001   
2019 Wang DD, Jin MF, Zhao DJ, Ni H. Reduction of Mitophagy-Related Oxidative Stress and Preservation of Mitochondria Function Using Melatonin Therapy in an HT22 Hippocampal Neuronal Cell Model of Glutamate-Induced Excitotoxicity. Frontiers in Endocrinology. 10: 550. PMID 31440210 DOI: 10.3389/fendo.2019.00550   
2019 Bahhir D, Yalgin C, Ots L, Järvinen S, George J, Naudí A, Krama T, Krams I, Tamm M, Andjelković A, Dufour E, González de Cózar JM, Gerards M, Parhiala M, Pamplona R, et al. Manipulating mtDNA in vivo reprograms metabolism via novel response mechanisms. Plos Genetics. 15: e1008410. PMID 31584940 DOI: 10.1371/journal.pgen.1008410   
2019 Petersen KF, Dufour S, Cline GW, Shulman GI. Regulation of hepatic mitochondrial oxidation by glucose-alanine cycling during starvation in humans. The Journal of Clinical Investigation. PMID 31545298 DOI: 10.1172/JCI129913   
2019 Veloso CD, Belew GD, Ferreira LL, Grilo LFF, Jones JG, Portincasa P, Sardão VA, Oliveira PJ. A Mitochondrial Approach to Cardiovascular Risk and Disease. Current Protein & Peptide Science. PMID 31470786 DOI: 10.2174/1389203720666190830163735   
2019 Roy S, Kim D, Sankaramoorthy A. Mitochondrial Structural Changes in the Pathogenesis of Diabetic Retinopathy. Journal of Clinical Medicine. 8. PMID 31480638 DOI: 10.3390/jcm8091363   
2019 Zheng F, Jia B, Dong F, Liu L, Rasul F, He J, Fu C. Glucose starvation induces mitochondrial fragmentation depending on the dynamin GTPase Dnm1/Drp1 in fission yeast. The Journal of Biological Chemistry. PMID 31562247 DOI: 10.1074/jbc.RA119.010185   
2019 Lee TI, Kao YH, Baigalmaa L, Lee TW, Lu YY, Chen YC, Chao TF, Chen YJ. Sodium hydrosulphide restores tumour necrosis factor-α-induced mitochondrial dysfunction and metabolic dysregulation in HL-1 cells. Journal of Cellular and Molecular Medicine. PMID 31496037 DOI: 10.1111/jcmm.14637   
2019 McMurray F, MacFarlane M, Kim K, Patten DA, Wei-LaPierre L, Fullerton MD, Harper ME. Maternal diet-induced obesity alters muscle mitochondrial function in offspring without changing insulin sensitivity. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201901150R. PMID 31581846 DOI: 10.1096/fj.201901150R   
2019 Wang J, Sun J, Qiao S, Li H, Che T, Wang C, An J. Effects of isoflurane on complex II‑associated mitochondrial respiration and reactive oxygen species production: Roles of nitric oxide and mitochondrial KATP channels. Molecular Medicine Reports. PMID 31545457 DOI: 10.3892/mmr.2019.10658   
2019 Ljubkovic M, Gressette M, Bulat C, Cavar M, Bakovic D, Fabijanic D, Grkovic I, Lemaire C, Marinovic J. Disturbed Fatty Acid Oxidation, Endoplasmic Reticulum Stress and Apoptosis in Left Ventricle of Patients with Type 2 Diabetes Mellitus. Diabetes. PMID 31391173 DOI: 10.2337/db19-0423   
2019 Dai C, Xiao X, Sun F, Zhang Y, Hoyer D, Shen J, Tang S, Velkov T. T-2 toxin neurotoxicity: role of oxidative stress and mitochondrial dysfunction. Archives of Toxicology. PMID 31570981 DOI: 10.1007/s00204-019-02577-5   
2019 Blajszczak CC, Nonn L. Vitamin D regulates prostate cell metabolism via genomic and non-genomic mitochondrial redox-dependent mechanisms. The Journal of Steroid Biochemistry and Molecular Biology. 105484. PMID 31574299 DOI: 10.1016/j.jsbmb.2019.105484   
2019 Wang L, Ren X, Guo W, Wang D, Han L, Feng J. Oxidative Stress and Apoptosis of () Induced by Carabrone. Journal of Agricultural and Food Chemistry. PMID 31453693 DOI: 10.1021/acs.jafc.9b02951   
2019 Zhang R, Hou T, Cheng H, Wang X. NDUFAB1 protects against obesity and insulin resistance by enhancing mitochondrial metabolism. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201901117RR. PMID 31530015 DOI: 10.1096/fj.201901117RR   
2019 Kim EJ, Lee M, Kim DY, Kim KI, Yi JY. Mechanisms of Energy Metabolism in Skeletal Muscle Mitochondria Following Radiation Exposure. Cells. 8. PMID 31438652 DOI: 10.3390/cells8090950   
2019 Hahn A, Zuryn S. Mitochondrial Genome (mtDNA) Mutations that Generate Reactive Oxygen Species. Antioxidants (Basel, Switzerland). 8. PMID 31514455 DOI: 10.3390/antiox8090392   
2019 Lang AL, Krueger AM, Schnegelberger RD, Kaelin BR, Rakutt MJ, Chen L, Arteel GE, Beier JI. Rapamycin attenuates liver injury caused by vinyl chloride metabolite chloroethanol and lipopolysaccharide in mice. Toxicology and Applied Pharmacology. 114745. PMID 31499194 DOI: 10.1016/j.taap.2019.114745   
2019 Cho HY, Kleeberger SR. Mitochondrial biology in airway pathogenesis and the role of NRF2. Archives of Pharmacal Research. PMID 31486024 DOI: 10.1007/s12272-019-01182-5   
2019 Ozkurede U, Miller RA. Improved mitochondrial stress response in long-lived Snell dwarf mice. Aging Cell. e13030. PMID 31423721 DOI: 10.1111/acel.13030   
2019 Kumar V, A AK, Sanawar R, Jaleel A, Santhosh Kumar TR, Kartha CC. Chronic Pressure Overload Results in Deficiency of Mitochondrial Membrane Transporter ABCB7 Which Contributes to Iron Overload, Mitochondrial Dysfunction, Metabolic Shift and Worsens Cardiac Function. Scientific Reports. 9: 13170. PMID 31511561 DOI: 10.1038/s41598-019-49666-0   
2019 Malik AN, Simões ICM, Rosa HS, Khan S, Karkucinska-Wieckowska A, Wieckowski MR. A Diet Induced Maladaptive Increase in Hepatic Mitochondrial DNA Precedes OXPHOS Defects and May Contribute to Non-Alcoholic Fatty Liver Disease. Cells. 8. PMID 31597406 DOI: 10.3390/cells8101222   
2019 Zhao H, Wang Y, Guo M, Fei D, Mu M, Yu H, Xing M. Hepatoprotective effects of zinc (II) via cytochrome P-450/reactive oxygen species and canonical apoptosis pathways after arsenite waterborne exposure in common carp. Chemosphere. 236: 124869. PMID 31549675 DOI: 10.1016/j.chemosphere.2019.124869   
2019 Lee WC, Chau YY, Ng HY, Chen CH, Wang PW, Liou CW, Lin TK, Chen JB. Empagliflozin Protects HK-2 Cells from High Glucose-Mediated Injuries via a Mitochondrial Mechanism. Cells. 8. PMID 31540085 DOI: 10.3390/cells8091085   
2019 Wang W, Wang M, Ruan Y, Tan J, Wang H, Yang T, Li J, Zhou Q. Ginkgolic acids impairs mitochondrial function by decreasing mitochondrial biogenesis and promoting FUNDC1-dependent mitophagy. Journal of Agricultural and Food Chemistry. PMID 31418272 DOI: 10.1021/acs.jafc.9b04178   
2019 Canugovi C, Stevenson MD, Vendrov AE, Hayami T, Robidoux J, Xiao H, Zhang YY, Eitzman DT, Runge MS, Madamanchi NR. Increased mitochondrial NADPH oxidase 4 (NOX4) expression in aging is a causative factor in aortic stiffening. Redox Biology. 26: 101288. PMID 31419754 DOI: 10.1016/j.redox.2019.101288   
2019 Nagasu H, Sogawa Y, Kidokoro K, Itano S, Yamamoto T, Satoh M, Sasaki T, Suzuki T, Yamamoto M, Wigley WC, Proksch JW, Meyer CJ, Kashihara N. Bardoxolone methyl analog attenuates proteinuria-induced tubular damage by modulating mitochondrial function. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201900217R. PMID 31431054 DOI: 10.1096/fj.201900217R   
2019 Ji X, Khdour OM, Hecht SM. Multifunctional radical quenchers as potential therapeutic agents for the treatment of mitochondrial dysfunction. Future Medicinal Chemistry. 11: 1605-1624. PMID 31469329 DOI: 10.4155/fmc-2018-0481   
2019 Nagashima S, Takeda K, Ohno N, Ishido S, Aoki M, Saitoh Y, Takada T, Tokuyama T, Sugiura A, Fukuda T, Matsushita N, Inatome R, Yanagi S. MITOL deletion in the brain impairs mitochondrial structure and ER tethering leading to oxidative stress. Life Science Alliance. 2. PMID 31416892 DOI: 10.26508/lsa.201900308   
2019 Maglioni S, Mello DF, Schiavi A, Meyer JN, Ventura N. Mitochondrial bioenergetic changes during development as an indicator of health-span. Aging. 11: 6535-6554. PMID 31454791 DOI: 10.18632/aging.102208   
2019 Plotnikov EY, Zorov DB. Pros and Cons of Use of Mitochondria-Targeted Antioxidants. Antioxidants (Basel, Switzerland). 8. PMID 31426455 DOI: 10.3390/antiox8080316   
2019 Softic S, Meyer JG, Wang GX, Gupta MK, Batista TM, Lauritzen HPMM, Fujisaka S, Serra D, Herrero L, Willoughby J, Fitzgerald K, Ilkayeva O, Newgard CB, Gibson BW, Schilling B, et al. Dietary Sugars Alter Hepatic Fatty Acid Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins. Cell Metabolism. 30: 735-753.e4. PMID 31577934 DOI: 10.1016/j.cmet.2019.09.003   
2019 Bonezzi F, Piccoli M, Dei Cas M, Paroni R, Mingione A, Monasky MM, Caretti A, Riganti C, Ghidoni R, Pappone C, Anastasia L, Signorelli P. Sphingolipid Synthesis Inhibition by Myriocin Administration Enhances Lipid Consumption and Ameliorates Lipid Response to Myocardial Ischemia Reperfusion Injury. Frontiers in Physiology. 10: 986. PMID 31447688 DOI: 10.3389/fphys.2019.00986   
2019 Xu J, Guan Y, Yu Z, Zhang C, Guan F, Liu F. [Gene knockout technology and its application in the study of the relationship between mitochondrial dynamics and insulin resistance]. Sheng Wu Gong Cheng Xue Bao = Chinese Journal of Biotechnology. 35: 1382-1390. PMID 31441609 DOI: 10.13345/j.cjb.190121   
2019 Xu J, Guan Y, Yu Z, Zhang C, Guan F, Liu F. [Gene knockout technology and its application in the study of the relationship between mitochondrial dynamics and insulin resistance]. Sheng Wu Gong Cheng Xue Bao = Chinese Journal of Biotechnology. 35: 1382-1390. PMID 31441609 DOI: 10.13345/j.cjb.190121   
2019 Li J, Wang PY, Long NA, Zhuang J, Springer DA, Zou J, Lin Y, Bleck CKE, Park JH, Kang JG, Hwang PM. p53 prevents doxorubicin cardiotoxicity independently of its prototypical tumor suppressor activities. Proceedings of the National Academy of Sciences of the United States of America. PMID 31488712 DOI: 10.1073/pnas.1904979116   
2019 Liu K, Jing MJ, Liu C, Yan DY, Ma Z, Wang C, Deng Y, Liu W, Xu B. Effect of Trehalose on Manganese-induced Mitochondrial Dysfunction and Neuronal Cells Damage in Mice. Basic & Clinical Pharmacology & Toxicology. PMID 31483928 DOI: 10.1111/bcpt.13316   
2019 Kim YS, Kim EK, Dong X, Shin WB, Park JS, Kim SJ, Go EA, Byun HG, Park PJ. Antioxidant Activities of Viviparus Contectus Extract Against Tert-Butylhydroperoxide-Induced Oxidative Stress. Advances in Experimental Medicine and Biology. 1155: 611-626. PMID 31468435 DOI: 10.1007/978-981-13-8023-5_55   
2019 Wiersma M, van Marion DMS, Wüst RCI, Houtkooper RH, Zhang D, Groot NMS, Henning RH, Brundel BJJM. Mitochondrial Dysfunction Underlies Cardiomyocyte Remodeling in Experimental and Clinical Atrial Fibrillation. Cells. 8. PMID 31590355 DOI: 10.3390/cells8101202   
2019 Jiang H, Jin J, Duan Y, Xie Z, Li Y, Gao A, Gu M, Zhang X, Peng C, Xia C, Dong T, Li H, Yu L, Tang J, Yang F, et al. Mitochondrial Uncoupling Coordinated With PDH Activation Safely Ameliorates Hyperglycemia Via Promoting Glucose Oxidation. Diabetes. PMID 31471292 DOI: 10.2337/db19-0589   
2019 Liu C, Cui Y, Pi F, Guo Y, Cheng Y, Qian H. Torularhodin Ameliorates Oxidative Activity in Vitro and D-galactose-induced Liver Injury via the Nrf2/HO-1 Signaling Pathway in Vivo. Journal of Agricultural and Food Chemistry. PMID 31431007 DOI: 10.1021/acs.jafc.9b03847   
2019 Liu T, Han Y, Zhou T, Zhang R, Chen H, Chen S, Zhao H. Mechanisms of ROS-induced mitochondria-dependent apoptosis underlying liquid storage of goat spermatozoa. Aging. 11. PMID 31548434 DOI: 10.18632/aging.102295   
2019 Domingues CC, Kundu N, Kropotova Y, Ahmadi N, Sen S. Antioxidant-upregulated mesenchymal stem cells reduce inflammation and improve fatty liver disease in diet-induced obesity. Stem Cell Research & Therapy. 10: 280. PMID 31477174 DOI: 10.1186/s13287-019-1393-8   
2019 Quadri MM, Fatima SS, Che RC, Zhang AH. Mitochondria and Renal Fibrosis. Advances in Experimental Medicine and Biology. 1165: 501-524. PMID 31399982 DOI: 10.1007/978-981-13-8871-2_25