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Jonathan A. Doorn, Ph.D. - Publications

Affiliations: 
2001 University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
Toxicology, Public Health, Environmental Sciences
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39 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Anderson DG, Florang VR, Schamp JH, Buettner GR, Doorn JA. Antioxidant-Mediated Modulation of Protein Reactivity for 3,4 Dihydroxyphenylacetaldehyde, a Toxic Dopamine Metabolite. Chemical Research in Toxicology. PMID 27268734 DOI: 10.1021/acs.chemrestox.5b00528  0.36
2014 Doorn JA, Florang VR, Schamp JH, Vanle BC. Aldehyde dehydrogenase inhibition generates a reactive dopamine metabolite autotoxic to dopamine neurons. Parkinsonism & Related Disorders. 20: S73-5. PMID 24262193 DOI: 10.1016/S1353-8020(13)70019-1  0.36
2013 Monroy CA, Doorn JA, Roman DL. Modification and functional inhibition of regulator of G-protein signaling 4 (RGS4) by 4-hydroxy-2-nonenal. Chemical Research in Toxicology. 26: 1832-9. PMID 24229325 DOI: 10.1021/tx400212q  0.36
2013 Allen EMG, Florang VR, Davenport LL, Jinsmaa Y, Doorn JA. Cellular localization of dieldrin and structure-activity relationship of dieldrin analogues in dopaminergic cells Chemical Research in Toxicology. 26: 1043-1054. PMID 23763672 DOI: 10.1021/tx300458b  0.36
2013 Vermeer LM, Higgins CA, Roman DL, Doorn JA. Real-time monitoring of tyrosine hydroxylase activity using a plate reader assay. Analytical Biochemistry. 432: 11-5. PMID 23010244 DOI: 10.1016/j.ab.2012.09.005  0.36
2013 Doorn JA, Anderson DG, Florang VR, Vermeer LMM, Eckert LL. 3,4-Dihydroxyphenylacetaldehyde is an Autotoxic and Protein-Reactive Intermediate of Dopamine Catabolism Catecholamine Research in the 21st Century: Abstracts and Graphical Abstracts, 10th International Catecholamine Symposium, 2012. 121-122. DOI: 10.1016/B978-0-12-800044-1.00104-5  0.36
2012 Vermeer LM, Florang VR, Doorn JA. Catechol and aldehyde moieties of 3,4-dihydroxyphenylacetaldehyde contribute to tyrosine hydroxylase inhibition and neurotoxicity. Brain Research. 1474: 100-9. PMID 22877852 DOI: 10.1016/j.brainres.2012.07.048  0.36
2012 Dean ED, Mexas LM, Cápiro NL, McKeon JE, DeLong MR, Pennell KD, Doorn JA, Tangpricha V, Miller GW, Evatt ML. 25-Hydroxyvitamin D depletion does not exacerbate MPTP-induced dopamine neuron damage in mice. Plos One. 7: e39227. PMID 22768297 DOI: 10.1371/journal.pone.0039227  0.36
2012 Higgins CA, Vermeer LM, Doorn JA, Roman DL. Expression and purification of recombinant human tyrosine hydroxylase as a fusion protein in Escherichia coli. Protein Expression and Purification. 84: 219-23. PMID 22659380 DOI: 10.1016/j.pep.2012.05.007  0.36
2011 Anderson DG, Mariappan SV, Buettner GR, Doorn JA. Oxidation of 3,4-dihydroxyphenylacetaldehyde, a toxic dopaminergic metabolite, to a semiquinone radical and an ortho-quinone. The Journal of Biological Chemistry. 286: 26978-86. PMID 21642436 DOI: 10.1074/jbc.M111.249532  0.36
2011 Mexas LM, Florang VR, Doorn JA. Inhibition and covalent modification of tyrosine hydroxylase by 3,4-dihydroxyphenylacetaldehyde, a toxic dopamine metabolite. Neurotoxicology. 32: 471-7. PMID 21514317 DOI: 10.1016/j.neuro.2011.03.013  0.36
2011 Jinsmaa Y, Florang VR, Rees JN, Mexas LM, Eckert LL, Allen EM, Anderson DG, Doorn JA. Dopamine-derived biological reactive intermediates and protein modifications: Implications for Parkinson's disease. Chemico-Biological Interactions. 192: 118-21. PMID 21238438 DOI: 10.1016/j.cbi.2011.01.006  0.36
2010 Allen EM, Anderson DG, Florang VR, Khanna M, Hurley TD, Doorn JA. Relative inhibitory potency of molinate and metabolites with aldehyde dehydrogenase 2: implications for the mechanism of enzyme inhibition. Chemical Research in Toxicology. 23: 1843-50. PMID 20954713 DOI: 10.1021/tx100317q  0.36
2010 Doorn JA. Dopamine Catabolism and Parkinson's Disease: Role of a Reactive Aldehyde Intermediate Endogenous Toxins: Targets For Disease Treatment and Prevention. 715-731. DOI: 10.1002/9783527628100.ch29  0.36
2009 Roberts RA, Laskin DL, Smith CV, Robertson FM, Allen EM, Doorn JA, Slikker W. Nitrative and oxidative stress in toxicology and disease. Toxicological Sciences : An Official Journal of the Society of Toxicology. 112: 4-16. PMID 19656995 DOI: 10.1093/toxsci/kfp179  0.36
2009 Gall AJ, Joshi B, Best J, Florang VR, Doorn JA, Blumberg MS. Developmental emergence of power-law wake behavior depends upon the functional integrity of the locus coeruleus. Sleep. 32: 920-6. PMID 19639755  0.36
2009 Rees JN, Florang VR, Eckert LL, Doorn JA. Protein reactivity of 3,4-dihydroxyphenylacetaldehyde, a toxic dopamine metabolite, is dependent on both the aldehyde and the catechol. Chemical Research in Toxicology. 22: 1256-63. PMID 19537779 DOI: 10.1021/tx9000557  0.36
2009 Stewart BJ, Roede JR, Doorn JA, Petersen DR. Lipid aldehyde-mediated cross-linking of apolipoprotein B-100 inhibits secretion from HepG2 cells. Biochimica Et Biophysica Acta. 1791: 772-80. PMID 19393338 DOI: 10.1016/j.bbalip.2009.04.004  0.36
2009 Jinsmaa Y, Florang VR, Rees JN, Anderson DG, Strack S, Doorn JA. Products of oxidative stress inhibit aldehyde oxidation and reduction pathways in dopamine catabolism yielding elevated levels of a reactive intermediate. Chemical Research in Toxicology. 22: 835-41. PMID 19388687 DOI: 10.1021/tx800405v  0.36
2008 Roede JR, Carbone DL, Doorn JA, Kirichenko OV, Reigan P, Petersen DR. In vitro and in silico characterization of peroxiredoxin 6 modified by 4-hydroxynonenal and 4-oxononenal. Chemical Research in Toxicology. 21: 2289-99. PMID 19548352 DOI: 10.1021/tx800244u  0.36
2007 Sampey BP, Carbone DL, Doorn JA, Drechsel DA, Petersen DR. 4-Hydroxy-2-nonenal adduction of extracellular signal-regulated kinase (Erk) and the inhibition of hepatocyte Erk-Est-like protein-1-activating protein-1 signal transduction. Molecular Pharmacology. 71: 871-83. PMID 17164404 DOI: 10.1124/mol.106.029686  0.36
2007 Florang VR, Rees JN, Brogden NK, Anderson DG, Hurley TD, Doorn JA. Inhibition of the oxidative metabolism of 3,4-dihydroxyphenylacetaldehyde, a reactive intermediate of dopamine metabolism, by 4-hydroxy-2-nonenal. Neurotoxicology. 28: 76-82. PMID 16956664 DOI: 10.1016/j.neuro.2006.07.018  0.36
2006 Doorn JA, Hurley TD, Petersen DR. Inhibition of human mitochondrial aldehyde dehydrogenase by 4-hydroxynon-2-enal and 4-oxonon-2-enal. Chemical Research in Toxicology. 19: 102-10. PMID 16411662 DOI: 10.1021/tx0501839  0.36
2005 Carbone DL, Doorn JA, Kiebler Z, Petersen DR. Cysteine modification by lipid peroxidation products inhibits protein disulfide isomerase. Chemical Research in Toxicology. 18: 1324-31. PMID 16097806 DOI: 10.1021/tx050078z  0.36
2005 Carbone DL, Doorn JA, Kiebler Z, Ickes BR, Petersen DR. Modification of heat shock protein 90 by 4-hydroxynonenal in a rat model of chronic alcoholic liver disease. The Journal of Pharmacology and Experimental Therapeutics. 315: 8-15. PMID 15951401 DOI: 10.1124/jpet.105.088088  0.36
2004 Carbone DL, Doorn JA, Kiebler Z, Sampey BP, Petersen DR. Inhibition of Hsp72-mediated protein refolding by 4-hydroxy-2-nonenal. Chemical Research in Toxicology. 17: 1459-67. PMID 15540944 DOI: 10.1021/tx049838g  0.36
2004 Doorn JA, Maser E, Blum A, Claffey DJ, Petersen DR. Human carbonyl reductase catalyzes reduction of 4-oxonon-2-enal. Biochemistry. 43: 13106-14. PMID 15476404 DOI: 10.1021/bi049136q  0.36
2004 Carbone DL, Doorn JA, Petersen DR. 4-Hydroxynonenal regulates 26S proteasomal degradation of alcohol dehydrogenase. Free Radical Biology & Medicine. 37: 1430-9. PMID 15454282 DOI: 10.1016/j.freeradbiomed.2004.07.016  0.36
2004 Petersen DR, Doorn JA. Reactions of 4-hydroxynonenal with proteins and cellular targets. Free Radical Biology & Medicine. 37: 937-45. PMID 15336309 DOI: 10.1016/j.freeradbiomed.2004.06.012  0.36
2003 Doorn JA, Srivastava SK, Petersen DR. Aldose reductase catalyzes reduction of the lipid peroxidation product 4-oxonon-2-enal. Chemical Research in Toxicology. 16: 1418-23. PMID 14615967 DOI: 10.1021/tx0300378  0.36
2003 Doorn JA, Thompson CM, Christner RB, Richardson RJ. Stereoselective inactivation of Torpedo californica acetylcholinesterase by isomalathion: inhibitory reactions with (1R)- and (1S)-isomers proceed by different mechanisms. Chemical Research in Toxicology. 16: 958-65. PMID 12924923 DOI: 10.1021/tx030026e  0.36
2003 Reichard JF, Doorn JA, Simon F, Taylor MS, Petersen DR. Characterization of multidrug resistance-associated protein 2 in the hepatocellular disposition of 4-hydroxynonenal. Archives of Biochemistry and Biophysics. 411: 243-50. PMID 12623073 DOI: 10.1016/S0003-9861(03)00002-X  0.36
2003 Doorn JA, Petersen DR. Covalent adduction of nucleophilic amino acids by 4-hydroxynonenal and 4-oxononenal. Chemico-Biological Interactions. 143: 93-100. PMID 12604193 DOI: 10.1016/S0009-2797(02)00178-3  0.36
2002 Doorn JA, Petersen DR. Covalent modification of amino acid nucleophiles by the lipid peroxidation products 4-hydroxy-2-nonenal and 4-oxo-2-nonenal. Chemical Research in Toxicology. 15: 1445-50. PMID 12437335 DOI: 10.1021/tx025590o  0.36
2001 Doorn JA, Schall M, Gage DA, Talley TT, Thompson CM, Richardson RJ. Identification of butyrylcholinesterase adducts after inhibition with isomalathion using mass spectrometry: difference in mechanism between (1R)- and (1S)-stereoisomers. Toxicology and Applied Pharmacology. 176: 73-80. PMID 11601883 DOI: 10.1006/taap.2001.9279  0.36
2001 Doorn JA, Talley TT, Thompson CM, Richardson RJ. Probing the active sites of butyrylcholinesterase and cholesterol esterase with isomalathion: conserved stereoselective inactivation of serine hydrolases structurally related to acetylcholinesterase. Chemical Research in Toxicology. 14: 807-13. PMID 11453726 DOI: 10.1021/tx015501s  0.36
2000 Doorn JA, Gage DA, Schall M, Talley TT, Thompson CM, Richardson RJ. Inhibition of acetylcholinesterase by (1S,3S)-isomalathion proceeds with loss of thiomethyl: kinetic and mass spectral evidence for an unexpected primary leaving group. Chemical Research in Toxicology. 13: 1313-20. PMID 11123973 DOI: 10.1021/tx000184v  0.36
1999 Billecke SS, Primo-Parmo SL, Dunlop CS, Doorn JA, La Du BN, Broomfield CA. Characterization of a soluble mouse liver enzyme capable of hydrolyzing diisopropyl phosphorofluoridate Chemico-Biological Interactions. 119: 251-256. PMID 10421459 DOI: 10.1016/S0009-2797(99)00034-4  0.36
1999 Doorn JA, Sorenson RC, Billecke SS, Hsu C, La Du BN. Evidence that several conserved histidine residues are required for hydrolytic activity of human paraoxonase/arylesterase. Chemico-Biological Interactions. 119: 235-41. PMID 10421457 DOI: 10.1016/S0009-2797(99)00032-0  0.36
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