Xiongwen Chen, Ph.D. - Publications

Affiliations: 
2003 Temple University, Philadelphia, PA, United States 
Area:
Pathology, Medical Biophysics, Biomedical Engineering

81 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Yang J, Zhang X, Yi L, Yang L, Wang WE, Zeng C, Mi M, Chen X. Hepatic PKA inhibition accelerates the lipid accumulation in liver. Nutrition & Metabolism. 16: 69. PMID 31632452 DOI: 10.1186/s12986-019-0400-5  1
2019 Chen X, Zhang X, Gross S, Houser SR, Soboloff J. Acetylation of SERCA2a, Another Target for Heart Failure Treatment? Circulation Research. 124: 1285-1287. PMID 31021723 DOI: 10.1161/CIRCRESAHA.119.315017  1
2019 Zhang Y, Wang WE, Zhang X, Li Y, Chen B, Liu C, Ai X, Zhang X, Tian Y, Zhang C, Tang M, Szeto C, Hua X, Xie M, Zeng C, ... ... Chen X, et al. Cardiomyocyte PKA Ablation Enhances Basal Contractility While Eliminates Cardiac β-Adrenergic Response Without Adverse Effects on the Heart. Circulation Research. PMID 30982412 DOI: 10.1161/CIRCRESAHA.118.313417  1
2019 Cao T, Liccardo D, LaCanna R, Zhang X, Lu R, Finck BN, Leigh T, Chen X, Drosatos K, Tian Y. Fatty Acid Oxidation Promotes Cardiomyocyte Proliferation Rate but Does Not Change Cardiomyocyte Number in Infant Mice. Frontiers in Cell and Developmental Biology. 7: 42. PMID 30968022 DOI: 10.3389/fcell.2019.00042  1
2019 Luo Z, Niu J, Zhang L, Chen X, Zhang W, Xie B, Du J, Zhu Z, Wu S, Li X. Roots-Enhanced Preferential Flows in Deciduous and Coniferous Forest Soils Revealed by Dual-Tracer Experiments. Journal of Environmental Quality. 48: 136-146. PMID 30640350 DOI: 10.2134/jeq2018.03.0091  1
2019 Yang D, Fu W, Li L, Xia X, Liao Q, Yue R, Chen H, Chen X, An S, Zeng C, Wang WE. Correction: Therapeutic effect of a novel Wnt pathway inhibitor on cardiac regeneration after myocardial infarction. Clinical Science (London, England : 1979). 133: 149. PMID 30635389 DOI: 10.1042/CS20171256_COR  1
2018 Zhang C, Deng Y, Liu Y, Xu Y, Liu Y, Zhang L, Chen X, Xie M, Ge S. Preclinical cardiovascular changes in children with obesity: A real-time 3-dimensional speckle tracking imaging study. Plos One. 13: e0205177. PMID 30308043 DOI: 10.1371/journal.pone.0205177  1
2018 Jiang J, Lan C, Li L, Yang D, Xia X, Liao Q, Fu W, Chen X, An S, Wang WE, Zeng C. A novel porcupine inhibitor blocks WNT pathways and attenuates cardiac hypertrophy. Biochimica Et Biophysica Acta. PMID 30076960 DOI: 10.1016/j.bbadis.2018.07.035  1
2018 Yang X, Yue R, Zhang J, Zhang X, Liu Y, Chen C, Wang X, Luo H, Wang WE, Chen X, Wang HJ, Jose PA, Wang H, Zeng C. Gastrin Protects Against Myocardial Ischemia/Reperfusion Injury via Activation of RISK (Reperfusion Injury Salvage Kinase) and SAFE (Survivor Activating Factor Enhancement) Pathways. Journal of the American Heart Association. 7. PMID 30005556 DOI: 10.1161/JAHA.116.005171  1
2017 Zeng C, Yang D, Fu W, Li L, Xia X, Liao Q, Yue R, Chen H, Chen X, An S, Wang WE. Therapeutic Effect of a Novel Wnt Pathway Inhibitor on Cardiac Regeneration after Myocardial Infarction. Clinical Science (London, England : 1979). PMID 29162747 DOI: 10.1042/CS20171256  1
2017 Toib A, Zhang C, Borghetti G, Zhang X, Wallner M, Yang Y, Troupes C, Kubo H, Sharp T, Feldsott E, Berretta RM, Zalavadia N, Trappanese D, Harper S, Gross P, ... Chen X, et al. Remodeling of Repolarization and Arrhythmia Susceptibility in a Myosin Binding Protein C Knockout Mouse Model. American Journal of Physiology. Heart and Circulatory Physiology. ajpheart.00167.2017. PMID 28646025 DOI: 10.1152/ajpheart.00167.2017  1
2017 Wang WE, Li L, Xia X, Fu W, Liao Q, Lan C, Yang D, Chen H, Yue R, Zeng CS, Zhou L, Zhou B, Duan DD, Chen X, Houser SR, et al. Dedifferentiation, Proliferation and Redifferentiation of Adult Mammalian Cardiomyocytes After Ischemic Injury. Circulation. PMID 28642276 DOI: 10.1161/CIRCULATIONAHA.116.024307  1
2017 Troupes CD, Wallner M, Borghetti G, Zhang C, Mohsin S, von Lewinski D, Berretta RM, Kubo H, Chen X, Soboloff J, Houser SR. Role of STIM1 in Hypertrophy-Related Contractile Dysfunction. Circulation Research. PMID 28592415 DOI: 10.1161/CIRCRESAHA.117.311094  1
2017 Li Z, Li Y, Zhang L, Zhang X, Sullivan R, Ai X, Szeto C, Cai A, Liu L, Xiao W, Li Q, Ge S, Chen X. Reduced Myocardial Reserve in Young X-Linked Muscular Dystrophy Mice Diagnosed by Two-Dimensional Strain Analysis Combined with Stress Echocardiography. Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography. PMID 28511858 DOI: 10.1016/j.echo.2017.03.009  1
2017 Luongo TS, Lambert JP, Gross P, Nwokedi M, Lombardi AA, Shanmughapriya S, Carpenter AC, Kolmetzky D, Gao E, van Berlo JH, Tsai EJ, Molkentin JD, Chen X, Madesh M, Houser SR, et al. The mitochondrial Na(+)/Ca(2+) exchanger is essential for Ca(2+) homeostasis and viability. Nature. PMID 28445457 DOI: 10.1038/nature22082  1
2017 Correll RN, Makarewich CA, Zhang H, Zhang C, Sargent MA, York AJ, Berretta RM, Chen X, Houser SR, Molkentin JD. Caveolae-localized L-type Ca2+ channels do not contribute to function or hypertrophic signalling in the mouse heart. Cardiovascular Research. PMID 28402392 DOI: 10.1093/cvr/cvx046  1
2017 Wang Q, Dong B, Pokiniewski KA, Firrman J, Wu Z, Chin MP, Chen X, Liu L, Xu R, Diao Y, Xiao W. Syngeneic AAV Pseudo-particles Potentiate Gene Transduction of AAV Vectors. Molecular Therapy. Methods & Clinical Development. 4: 149-158. PMID 28345000 DOI: 10.1016/j.omtm.2016.12.004  1
2017 Li YF, Nanayakkara G, Sun Y, Li X, Wang L, Cueto R, Shao Y, Fu H, Johnson C, Cheng J, Chen X, Hu W, Yu J, Choi ET, Wang H, et al. Analyses of caspase-1-regulated transcriptomes in various tissues lead to identification of novel IL-1β-, IL-18- and sirtuin-1-independent pathways. Journal of Hematology & Oncology. 10: 40. PMID 28153032 DOI: 10.1186/s13045-017-0406-2  0.08
2017 Yue R, Fu W, Liao X, Lan C, Liao Q, Li L, Yang D, Xia X, Chen X, Zeng C, Wang WE. Metformin promotes the survival of transplanted cardiosphere-derived cells thereby enhancing their therapeutic effect against myocardial infarction. Stem Cell Research & Therapy. 8: 17. PMID 28129786 DOI: 10.1186/s13287-017-0476-7  1
2017 Cho GS, Lee DI, Tampakakis E, Murphy S, Andersen P, Uosaki H, Chelko S, Chakir K, Hong I, Seo K, Chen HV, Chen X, Basso C, Houser SR, Tomaselli GF, et al. Neonatal Transplantation Confers Maturation of PSC-Derived Cardiomyocytes Conducive to Modeling Cardiomyopathy. Cell Reports. 18: 571-582. PMID 28076798 DOI: 10.1016/j.celrep.2016.12.040  1
2016 Tao L, Bei Y, Chen P, Lei Z, Fu S, Zhang H, Xu J, Che L, Chen X, Sluijter JP, Das S, Cretoiu D, Xu B, Zhong J, Xiao J, et al. Crucial Role of miR-433 in Regulating Cardiac Fibrosis. Theranostics. 6: 2068-2083. PMID 27698941 DOI: 10.7150/thno.15007  1
2016 Chen X, O'Connell TD, Xiang YK. With or Without Langendorff: A New Method for Adult Myocyte Isolation to Be Tested With Time. Circulation Research. 119: 888-90. PMID 27688302 DOI: 10.1161/CIRCRESAHA.116.309734  1
2016 Han Y, Liao X, Gao Z, Yang S, Chen C, Liu Y, Wang WE, Wu G, Chen X, Jose PA, Zhang Y, Zeng C. cTnI Exacerbates Myocardial Ischemia/Reperfusion Injury by Inducing Adhesion of Monocytes to VECs via  TLR4/NF-κB-dependent Pathway. Clinical Science (London, England : 1979). PMID 27682003 DOI: 10.1042/CS20160373  1
2016 Cai Y, Yang Y, Chen X, He D, Zhang X, Wen X, Hu J, Fu C, Qiu D, Jose PA, Zeng C, Zhou L. Circulating "LncPPARδ" From Monocytes as a Novel Biomarker for Coronary Artery Diseases. Medicine. 95: e2360. PMID 26871769 DOI: 10.1097/MD.0000000000002360  1
2016 Gao Z, Han Y, Hu Y, Wu X, Wang Y, Zhang X, Fu J, Zou X, Zhang J, Chen X, Jose PA, Lu X, Zeng C. Targeting HO-1 by Epigallocatechin-3-Gallate Reduces Contrast-Induced Renal Injury via Anti-Oxidative Stress and Anti-Inflammation Pathways. Plos One. 11: e0149032. PMID 26866373 DOI: 10.1371/journal.pone.0149032  1
2016 Cai Y, Yang Y, Chen X, Wu G, Zhang X, Liu Y, Yu J, Wang X, Fu J, Li C, Jose PA, Zeng C, Zhou L. Circulating "lncRNA OTTHUMT00000387022" from Monocytes as a Novel Biomarker for Coronary Artery Disease. Cardiovascular Research. PMID 26857419 DOI: 10.1093/cvr/cvw022  1
2016 Nelson BR, Makarewich CA, Anderson DM, Winders BR, Troupes CD, Wu F, Reese AL, McAnally JR, Chen X, Kavalali ET, Cannon SC, Houser SR, Bassel-Duby R, Olson EN. A peptide encoded by a transcript annotated as long noncoding RNA enhances SERCA activity in muscle. Science (New York, N.Y.). 351: 271-275. PMID 26816378 DOI: 10.1126/science.aad4076  1
2016 Li L, Chen X, Wang WE, Zeng C. How to Improve the Survival of Transplanted Mesenchymal Stem Cell in Ischemic Heart? Stem Cells International. 2016: 9682757. PMID 26681958 DOI: 10.1155/2016/9682757  1
2016 Zhang X, Ai X, Nakayama H, Chen B, Harris DM, Tang M, Xie Y, Szeto C, Li Y, Li Y, Zhang H, Eckhart AD, Koch WJ, Molkentin JD, Chen X. Persistent increases in Ca(2+) influx through Cav1.2 shortens action potential and causes Ca(2+) overload-induced afterdepolarizations and arrhythmias. Basic Research in Cardiology. 111: 4. PMID 26611208 DOI: 10.1007/s00395-015-0523-4  1
2015 Kolpakov MA, Rafiq K, Guo X, Hooshdaran B, Wang T, Vlasenko L, Bashkirova YV, Zhang X, Chen X, Iftikhar S, Libonati JR, Kunapuli SP, Sabri A. Protease-activated receptor 4 deficiency offers cardioprotection after acute ischemia reperfusion injury. Journal of Molecular and Cellular Cardiology. PMID 26643815 DOI: 10.1016/j.yjmcc.2015.11.030  1
2015 Smith SC, Zhang X, Zhang X, Gross P, Starosta T, Mohsin S, Franti M, Gupta P, Hayes D, Myzithras M, Kahn J, Tanner J, Weldon SM, Khalil A, Guo X, ... ... Chen X, et al. GDF11 Does Not Rescue Aging-Related Pathological Hypertrophy. Circulation Research. PMID 26383970 DOI: 10.1161/CIRCRESAHA.115.307527  1
2015 Correll RN, Goonasekera SA, van Berlo JH, Burr AR, Accornero F, Zhang H, Makarewich CA, York AJ, Sargent MA, Chen X, Houser SR, Molkentin JD. STIM1 elevation in the heart results in aberrant Ca(2+) handling and cardiomyopathy. Journal of Molecular and Cellular Cardiology. PMID 26241845 DOI: 10.1016/j.yjmcc.2015.07.032  1
2015 Yang Y, Cai Y, Wu G, Chen X, Liu Y, Wang X, Yu J, Li C, Chen X, Jose PA, Zhou L, Zeng C. Plasma long non-coding RNA, CoroMarker, a novel biomarker for diagnosis of coronary artery disease. Clinical Science (London, England : 1979). 129: 675-85. PMID 26201019 DOI: 10.1042/CS20150121  1
2015 Zhang XQ, Wang J, Song J, Rabinowitz J, Chen X, Houser SR, Peterson BZ, Tucker AL, Feldman AM, Cheung JY. Regulation of L-type calcium channel by phospholemman in cardiac myocytes. Journal of Molecular and Cellular Cardiology. 84: 104-11. PMID 25918050 DOI: 10.1016/j.yjmcc.2015.04.017  1
2015 Isidori AM, Cornacchione M, Barbagallo F, Di Grazia A, Barrios F, Fassina L, Monaco L, Giannetta E, Gianfrilli D, Garofalo S, Zhang X, Chen X, Xiang YK, Lenzi A, Pellegrini M, et al. Inhibition of type 5 phosphodiesterase counteracts β2-adrenergic signalling in beating cardiomyocytes. Cardiovascular Research. 106: 408-20. PMID 25852085 DOI: 10.1093/cvr/cvv123  1
2015 Schumacher SM, Gao E, Zhu W, Chen X, Chuprun JK, Feldman AM, G Tesmer JJ, Koch WJ. Paroxetine-mediated GRK2 inhibition reverses cardiac dysfunction and remodeling after myocardial infarction. Science Translational Medicine. 7: 277ra31. PMID 25739765 DOI: 10.1126/scitranslmed.aaa0154  1
2015 Yue R, Xia X, Jiang J, Yang D, Han Y, Chen X, Cai Y, Li L, Wang WE, Zeng C. Mitochondrial DNA oxidative damage contributes to cardiomyocyte ischemia/reperfusion-injury in rats: cardioprotective role of lycopene. Journal of Cellular Physiology. 230: 2128-41. PMID 25656550 DOI: 10.1002/jcp.24941  1
2014 Doonan PJ, Chandramoorthy HC, Hoffman NE, Zhang X, Cárdenas C, Shanmughapriya S, Rajan S, Vallem S, Chen X, Foskett JK, Cheung JY, Houser SR, Madesh M. LETM1-dependent mitochondrial Ca2+ flux modulates cellular bioenergetics and proliferation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 4936-49. PMID 25077561 DOI: 10.1096/fj.14-256453  1
2014 Makarewich CA, Zhang H, Davis J, Correll RN, Trappanese DM, Hoffman NE, Troupes CD, Berretta RM, Kubo H, Madesh M, Chen X, Gao E, Molkentin JD, Houser SR. Transient receptor potential channels contribute to pathological structural and functional remodeling after myocardial infarction. Circulation Research. 115: 567-80. PMID 25047165 DOI: 10.1161/CIRCRESAHA.115.303831  1
2014 Li Y, Zhang S, Zhang X, Li J, Ai X, Zhang L, Yu D, Ge S, Peng Y, Chen X. Blunted cardiac beta-adrenergic response as an early indication of cardiac dysfunction in Duchenne muscular dystrophy. Cardiovascular Research. 103: 60-71. PMID 24812281 DOI: 10.1093/cvr/cvu119  1
2014 Fu Q, Xu B, Liu Y, Parikh D, Li J, Li Y, Zhang Y, Riehle C, Zhu Y, Rawlings T, Shi Q, Clark RB, Chen X, Abel ED, Xiang YK. Insulin inhibits cardiac contractility by inducing a Gi-biased β2-adrenergic signaling in hearts. Diabetes. 63: 2676-89. PMID 24677713 DOI: 10.2337/db13-1763  1
2013 Li Y, Ge S, Peng Y, Chen X. Inflammation and cardiac dysfunction during sepsis, muscular dystrophy, and myocarditis. Burns & Trauma. 1: 109-21. PMID 27574633 DOI: 10.4103/2321-3868.123072  1
2013 Wang WE, Chen X, Houser SR, Zeng C. Potential of cardiac stem/progenitor cells and induced pluripotent stem cells for cardiac repair in ischaemic heart disease. Clinical Science (London, England : 1979). 125: 319-27. PMID 23746375 DOI: 10.1042/CS20130019  1
2013 Wang F, Gao H, Kubo H, Fan X, Zhang H, Berretta R, Chen X, Sharp T, Starosta T, Makarewich C, Li Y, Molkentin JD, Houser SR. T-type Ca²⁺ channels regulate the exit of cardiac myocytes from the cell cycle after birth. Journal of Molecular and Cellular Cardiology. 62: 122-30. PMID 23743021 DOI: 10.1016/j.yjmcc.2013.05.016  1
2013 Wang WE, Yang D, Li L, Wang W, Peng Y, Chen C, Chen P, Xia X, Wang H, Jiang J, Liao Q, Li Y, Xie G, Huang H, Guo Y, ... ... Chen X, et al. Prolyl hydroxylase domain protein 2 silencing enhances the survival and paracrine function of transplanted adipose-derived stem cells in infarcted myocardium. Circulation Research. 113: 288-300. PMID 23694817 DOI: 10.1161/CIRCRESAHA.113.300929  1
2013 Fu Q, Chen X, Xiang YK. Compartmentalization of β-adrenergic signals in cardiomyocytes. Trends in Cardiovascular Medicine. 23: 250-6. PMID 23528751 DOI: 10.1016/j.tcm.2013.02.001  1
2013 Zhang X, Szeto C, Gao E, Tang M, Jin J, Fu Q, Makarewich C, Ai X, Li Y, Tang A, Wang J, Gao H, Wang F, Ge XJ, Kunapuli SP, ... ... Chen X, et al. Cardiotoxic and cardioprotective features of chronic β-adrenergic signaling. Circulation Research. 112: 498-509. PMID 23104882 DOI: 10.1161/CIRCRESAHA.112.273896  1
2012 Li Y, Wang F, Zhang X, Qi Z, Tang M, Szeto C, Li Y, Zhang H, Chen X. β-Adrenergic stimulation increases Cav3.1 activity in cardiac myocytes through protein kinase A. Plos One. 7: e39965. PMID 22808078 DOI: 10.1371/journal.pone.0039965  1
2012 Raake PW, Zhang X, Vinge LE, Brinks H, Gao E, Jaleel N, Li Y, Tang M, Most P, Dorn GW, Houser SR, Katus HA, Chen X, Koch WJ. Cardiac G-protein-coupled receptor kinase 2 ablation induces a novel Ca2+ handling phenotype resistant to adverse alterations and remodeling after myocardial infarction. Circulation. 125: 2108-18. PMID 22496128 DOI: 10.1161/CIRCULATIONAHA.111.044255  1
2012 Liu S, Li Y, Kim S, Fu Q, Parikh D, Sridhar B, Shi Q, Zhang X, Guan Y, Chen X, Xiang YK. Phosphodiesterases coordinate cAMP propagation induced by two stimulatory G protein-coupled receptors in hearts. Proceedings of the National Academy of Sciences of the United States of America. 109: 6578-83. PMID 22493261 DOI: 10.1073/pnas.1117862109  1
2012 Zhang H, Makarewich CA, Kubo H, Wang W, Duran JM, Li Y, Berretta RM, Koch WJ, Chen X, Gao E, Valdivia HH, Houser SR. Hyperphosphorylation of the cardiac ryanodine receptor at serine 2808 is not involved in cardiac dysfunction after myocardial infarction. Circulation Research. 110: 831-40. PMID 22302785 DOI: 10.1161/CIRCRESAHA.111.255158  1
2012 Goonasekera SA, Hammer K, Auger-Messier M, Bodi I, Chen X, Zhang H, Reiken S, Elrod JW, Correll RN, York AJ, Sargent MA, Hofmann F, Moosmang S, Marks AR, Houser SR, et al. Decreased cardiac L-type Ca²⁺ channel activity induces hypertrophy and heart failure in mice. The Journal of Clinical Investigation. 122: 280-90. PMID 22133878 DOI: 10.1172/JCI58227  1
2011 Li C, Li J, Cai X, Sun H, Jiao J, Bai T, Zhou XW, Chen X, Gill DL, Tang XD. Protein kinase D3 is a pivotal activator of pathological cardiac hypertrophy by selectively increasing the expression of hypertrophic transcription factors. The Journal of Biological Chemistry. 286: 40782-91. PMID 21971046 DOI: 10.1074/jbc.M111.263046  1
2011 Smith ER, Zhang XY, Capo-Chichi CD, Chen X, Xu XX. Increased expression of Syne1/nesprin-1 facilitates nuclear envelope structure changes in embryonic stem cell differentiation. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 240: 2245-55. PMID 21932307 DOI: 10.1002/dvdy.22717  0.01
2011 Li C, Cai X, Sun H, Bai T, Zheng X, Zhou XW, Chen X, Gill DL, Li J, Tang XD. The δA isoform of calmodulin kinase II mediates pathological cardiac hypertrophy by interfering with the HDAC4-MEF2 signaling pathway. Biochemical and Biophysical Research Communications. 409: 125-30. PMID 21554860 DOI: 10.1016/j.bbrc.2011.04.128  1
2011 Angert D, Berretta RM, Kubo H, Zhang H, Chen X, Wang W, Ogorek B, Barbe M, Houser SR. Repair of the injured adult heart involves new myocytes potentially derived from resident cardiac stem cells. Circulation Research. 108: 1226-37. PMID 21454756 DOI: 10.1161/CIRCRESAHA.110.239046  1
2011 Chen X, Nakayama H, Zhang X, Ai X, Harris DM, Tang M, Zhang H, Szeto C, Stockbower K, Berretta RM, Eckhart AD, Koch WJ, Molkentin JD, Houser SR. Calcium influx through Cav1.2 is a proximal signal for pathological cardiomyocyte hypertrophy. Journal of Molecular and Cellular Cardiology. 50: 460-70. PMID 21111744 DOI: 10.1016/j.yjmcc.2010.11.012  1
2010 Zhang H, Chen X, Gao E, MacDonnell SM, Wang W, Kolpakov M, Nakayama H, Zhang X, Jaleel N, Harris DM, Li Y, Tang M, Berretta R, Leri A, Kajstura J, et al. Increasing cardiac contractility after myocardial infarction exacerbates cardiac injury and pump dysfunction Circulation Research. 107: 800-809. PMID 20671241 DOI: 10.1161/CIRCRESAHA.110.219220  1
2010 Tang M, Zhang X, Li Y, Guan Y, Ai X, Szeto C, Nakayama H, Zhang H, Ge S, Molkentin JD, Houser SR, Chen X. Enhanced basal contractility but reduced excitation-contraction coupling efficiency and beta-adrenergic reserve of hearts with increased Cav1.2 activity. American Journal of Physiology. Heart and Circulatory Physiology. 299: H519-28. PMID 20543081 DOI: 10.1152/ajpheart.00265.2010  1
2010 Zhou J, Lal H, Chen X, Shang X, Song J, Li Y, Kerkela R, Doble BW, MacAulay K, DeCaul M, Koch WJ, Farber J, Woodgett J, Gao E, Force T. GSK-3α directly regulates β-adrenergic signaling and the response of the heart to hemodynamic stress in mice Journal of Clinical Investigation. 120: 2280-2291. PMID 20516643 DOI: 10.1172/JCI41407  1
2010 Wang W, Zhang H, Gao H, Kubo H, Berretta RM, Chen X, Houser SR. {beta}1-Adrenergic receptor activation induces mouse cardiac myocyte death through both L-type calcium channel-dependent and -independent pathways. American Journal of Physiology. Heart and Circulatory Physiology. 299: H322-31. PMID 20495143 DOI: 10.1152/ajpheart.00392.2010  1
2009 Nakayama H, Bodi I, Correll RN, Chen X, Lorenz J, Houser SR, Robbins J, Schwartz A, Molkentin JD. alpha1G-dependent T-type Ca2+ current antagonizes cardiac hypertrophy through a NOS3-dependent mechanism in mice. The Journal of Clinical Investigation. 119: 3787-96. PMID 19920353 DOI: 10.1172/JCI39724  1
2009 MacDonnell SM, Weisser-Thomas J, Kubo H, Hanscome M, Liu Q, Jaleel N, Berretta R, Chen X, Brown JH, Sabri AK, Molkentin JD, Houser SR. CaMKII negatively regulates calcineurin-NFAT signaling in cardiac myocytes. Circulation Research. 105: 316-25. PMID 19608982 DOI: 10.1161/CIRCRESAHA.109.194035  1
2009 Liu Q, Chen X, Macdonnell SM, Kranias EG, Lorenz JN, Leitges M, Houser SR, Molkentin JD. Protein kinase C{alpha}, but not PKC{beta} or PKC{gamma}, regulates contractility and heart failure susceptibility: implications for ruboxistaurin as a novel therapeutic approach. Circulation Research. 105: 194-200. PMID 19556521 DOI: 10.1161/CIRCRESAHA.109.195313  1
2009 Harris DM, Chen X, Pesant S, Cohn HI, MacDonnell SM, Boucher M, Vinge LE, Raake P, Moraca SR, Li D, Most P, Houser SR, Koch WJ, Eckhart AD. Inhibition of angiotensin II Gq signaling augments β-adrenergic receptor mediated effects in a renal artery stenosis model of high blood pressure Journal of Molecular and Cellular Cardiology. 46: 100-107. PMID 18930063 DOI: 10.1016/j.yjmcc.2008.09.708  1
2008 Jaleel N, Nakayama H, Chen X, Kubo H, MacDonnell S, Zhang H, Berretta R, Robbins J, Cribbs L, Molkentin JD, Houser SR. Ca2+ influx through T- and L-type Ca2+ channels have different effects on myocyte contractility and induce unique cardiac phenotypes. Circulation Research. 103: 1109-19. PMID 18832749 DOI: 10.1161/CIRCRESAHA.108.185611  1
2008 Muraski JA, Fischer KM, Wu W, Cottage CT, Quijada P, Mason M, Din S, Gude N, Alvarez R, Rota M, Kajstura J, Wang Z, Schaefer E, Chen X, MacDonnel S, et al. Pim-1 kinase antagonizes aspects of myocardial hypertrophy and compensation to pathological pressure overload. Proceedings of the National Academy of Sciences of the United States of America. 105: 13889-94. PMID 18784362 DOI: 10.1073/pnas.0709135105  1
2008 Raake PW, Vinge LE, Gao E, Boucher M, Rengo G, Chen X, Degeorge BR, Matkovich S, Houser SR, Most P, Eckhart AD, Dorn GW, Koch WJ. G protein-coupled receptor kinase 2 ablation in cardiac myocytes before or after myocardial infarction prevents heart failure Circulation Research. 103: 413-422. PMID 18635825 DOI: 10.1161/CIRCRESAHA.107.168336  1
2008 MacDonnell SM, García-Rivas G, Scherman JA, Kubo H, Chen X, Valdivia H, Houser SR. Adrenergic regulation of cardiac contractility does not involve phosphorylation of the cardiac ryanodine receptor at serine 2808. Circulation Research. 102: e65-72. PMID 18388322 DOI: 10.1161/CIRCRESAHA.108.174722  1
2008 Chen X, Zhang X, Harris DM, Piacentino V, Berretta RM, Margulies KB, Houser SR. Reduced effects of BAY K 8644 on L-type Ca2+ current in failing human cardiac myocytes are related to abnormal adrenergic regulation. American Journal of Physiology. Heart and Circulatory Physiology. 294: H2257-67. PMID 18359894 DOI: 10.1152/ajpheart.01335.2007  1
2008 Tzeng HP, Fan J, Vallejo JG, Dong JW, Chen X, Houser SR, Mann DL. Negative inotropic effects of high-mobility group box 1 protein in isolated contracting cardiac myocytes. American Journal of Physiology. Heart and Circulatory Physiology. 294: H1490-6. PMID 18223193 DOI: 10.1152/ajpheart.00910.2007  1
2007 Rota M, Kajstura J, Hosoda T, Bearzi C, Vitale S, Esposito G, Iaffaldano G, Padin-Iruegas ME, Gonzalez A, Rizzi R, Small N, Muraski J, Alvarez R, Chen X, Urbanek K, et al. Bone marrow cells adopt the cardiomyogenic fate in vivo. Proceedings of the National Academy of Sciences of the United States of America. 104: 17783-8. PMID 17965233 DOI: 10.1073/pnas.0706406104  1
2007 MacDonnell SM, Kubo H, Harris DM, Chen X, Berretta R, Barbe MF, Kolwicz S, Reger PO, Eckhart A, Renna BF, Koch WJ, Houser SR, Libonati JR. Calcineurin inhibition normalizes beta-adrenergic responsiveness in the spontaneously hypertensive rat. American Journal of Physiology. Heart and Circulatory Physiology. 293: H3122-9. PMID 17827263 DOI: 10.1152/ajpheart.00687.2007  1
2007 Nakayama H, Chen X, Baines CP, Klevitsky R, Zhang X, Zhang H, Jaleel N, Chua BH, Hewett TE, Robbins J, Houser SR, Molkentin JD. Ca2+- and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure. The Journal of Clinical Investigation. 117: 2431-44. PMID 17694179 DOI: 10.1172/JCI31060  1
2007 Chen X, Wilson RM, Kubo H, Berretta RM, Harris DM, Zhang X, Jaleel N, MacDonnell SM, Bearzi C, Tillmanns J, Trofimova I, Hosoda T, Mosna F, Cribbs L, Leri A, et al. Adolescent feline heart contains a population of small, proliferative ventricular myocytes with immature physiological properties. Circulation Research. 100: 536-44. PMID 17272809 DOI: 10.1161/01.RES.0000259560.39234.99  1
2007 Mills GD, Harris DM, Chen X, Houser SR. Intracellular sodium determines frequency-dependent alterations in contractility in hypertrophied feline ventricular myocytes. American Journal of Physiology. Heart and Circulatory Physiology. 292: H1129-38. PMID 17012360 DOI: 10.1152/ajpheart.00375.2006  1
2006 Funakoshi H, Chan TO, Good JC, Libonati JR, Piuhola J, Chen X, MacDonnell SM, Lee LL, Herrmann DE, Zhang J, Martini J, Palmer TM, Sanbe A, Robbins J, Houser SR, et al. Regulated overexpression of the A1-adenosine receptor in mice results in adverse but reversible changes in cardiac morphology and function. Circulation. 114: 2240-50. PMID 17088462 DOI: 10.1161/CIRCULATIONAHA.106.620211  1
2005 Chen X, Zhang X, Kubo H, Harris DM, Mills GD, Moyer J, Berretta R, Potts ST, Marsh JD, Houser SR. Ca2+ influx-induced sarcoplasmic reticulum Ca2+ overload causes mitochondrial-dependent apoptosis in ventricular myocytes. Circulation Research. 97: 1009-17. PMID 16210547 DOI: 10.1161/01.RES.0000189270.72915.D1  1
2005 Harris DM, Mills GD, Chen X, Kubo H, Berretta RM, Votaw VS, Santana LF, Houser SR. Alterations in early action potential repolarization causes localized failure of sarcoplasmic reticulum Ca2+ release. Circulation Research. 96: 543-50. PMID 15705962 DOI: 10.1161/01.RES.0000158966.58380.37  1
2003 Piacentino V, Weber CR, Chen X, Weisser-Thomas J, Margulies KB, Bers DM, Houser SR. Cellular basis of abnormal calcium transients of failing human ventricular myocytes. Circulation Research. 92: 651-8. PMID 12600875 DOI: 10.1161/01.RES.0000062469.83985.9B  1
2002 Chen X, Piacentino V, Furukawa S, Goldman B, Margulies KB, Houser SR. L-type Ca2+ channel density and regulation are altered in failing human ventricular myocytes and recover after support with mechanical assist devices. Circulation Research. 91: 517-24. PMID 12242270 DOI: 10.1161/01.RES.0000033988.13062.7C  1
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