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Paul C. Spiegel, Ph.D. - Publications

Affiliations: 
2004 University of Washington, Seattle, Seattle, WA 
Area:
Molecular Biology, General Biophysics, Animal Physiology Biology
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11 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Childers KC, Avery NG, Estrada Alamo KA, Davulcu O, Haynes RM, Lollar P, Doering CB, Coxon CH, Spiegel PC. Structure of coagulation factor VIII bound to a patient-derived anti-C1 domain antibody inhibitor. Blood. PMID 37192299 DOI: 10.1182/blood.2023020181  0.339
2022 Childers KC, Peters SC, Spiegel PC. Structural insights into blood coagulation factor VIII: Procoagulant complexes, membrane binding, and antibody inhibition. Journal of Thrombosis and Haemostasis : Jth. PMID 35722946 DOI: 10.1111/jth.15793  0.334
2017 Carlson MA, Haddad BG, Weis AJ, Blackwood CS, Shelton CD, Wuerth ME, Walter JD, Spiegel PC. Ribosomal Protein L7/L12 is Required for GTPase Translation Factors EF-G, RF3 and IF2 to Bind in their GTP State to 70S Ribosomes. The Febs Journal. PMID 28342293 DOI: 10.1111/febs.14067  0.499
2015 Brison CM, Mullen SM, Wuerth ME, Podolsky K, Cook M, Herman JA, Walter JD, Meeks SL, Spiegel PC. The 1.7 Å X-ray crystal structure of the porcine factor VIII C2 domain and binding analysis to anti-human C2 domain antibodies and phospholipid surfaces. Plos One. 10: e0122447. PMID 25775247 DOI: 10.1371/journal.pone.0122447  0.32
2008 Shen BW, Spiegel PC, Chang CH, Huh JW, Lee JS, Kim J, Kim YH, Stoddard BL. The tertiary structure and domain organization of coagulation factor VIII. Blood. 111: 1240-7. PMID 17965321 DOI: 10.1182/Blood-2007-08-109918  0.523
2006 Spiegel PC, Chevalier B, Sussman D, Turmel M, Lemieux C, Stoddard BL. The structure of I-CeuI homing endonuclease: Evolving asymmetric DNA recognition from a symmetric protein scaffold. Structure (London, England : 1993). 14: 869-80. PMID 16698548 DOI: 10.1016/J.Str.2006.03.009  0.529
2004 Spiegel PC, Kaiser SM, Simon JA, Stoddard BL. Disruption of protein-membrane binding and identification of small-molecule inhibitors of coagulation factor VIII. Chemistry & Biology. 11: 1413-22. PMID 15489168 DOI: 10.1016/J.Chembiol.2004.08.006  0.525
2004 Spiegel PC, Murphy P, Stoddard BL. Surface-exposed hemophilic mutations across the factor VIII C2 domain have variable effects on stability and binding activities. The Journal of Biological Chemistry. 279: 53691-8. PMID 15471879 DOI: 10.1074/Jbc.M409389200  0.521
2003 Bolduc JM, Spiegel PC, Chatterjee P, Brady KL, Downing ME, Caprara MG, Waring RB, Stoddard BL. Structural and biochemical analyses of DNA and RNA binding by a bifunctional homing endonuclease and group I intron splicing factor. Genes & Development. 17: 2875-88. PMID 14633971 DOI: 10.1101/Gad.1109003  0.585
2002 Spiegel PC, Stoddard BL. Optimization of factor VIII replacement therapy: can structural studies help in evading antibody inhibitors? British Journal of Haematology. 119: 310-22. PMID 12406063 DOI: 10.1046/J.1365-2141.2002.03845.X  0.473
2001 Spiegel PC, Jacquemin M, Saint-Remy JM, Stoddard BL, Pratt KP. Structure of a factor VIII C2 domain-immunoglobulin G4kappa Fab complex: identification of an inhibitory antibody epitope on the surface of factor VIII. Blood. 98: 13-9. PMID 11418455 DOI: 10.1182/Blood.V98.1.13  0.55
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