Year |
Citation |
Score |
2019 |
Wei J, Leit S, Kuai J, Therrien E, Rafi S, Harwood HJ, DeLaBarre B, Tong L. An allosteric mechanism for potent inhibition of human ATP-citrate lyase. Nature. PMID 30944472 DOI: 10.1038/S41586-019-1094-6 |
0.413 |
|
2019 |
Wei J, Leit S, Kuai J, Therrien E, Rafi S, Harwood Jr HJ, DeLaBarre B, Tong L. Cryo-EM structure of human ATP-citrate lyase in complex with a potent inhibitor Acta Crystallographica Section a Foundations and Advances. 75: a371-a371. DOI: 10.1107/S0108767319096387 |
0.305 |
|
2017 |
Kung C, Hixon J, Kosinski PA, Cianchetta G, Histen G, Chen Y, Hill C, Gross S, Si Y, Johnson K, DeLaBarre B, Luo Z, Gu Z, Yao G, Tang H, et al. AG-348 enhances pyruvate kinase activity in red blood cells from patients with pyruvate kinase deficiency. Blood. PMID 28760888 DOI: 10.1182/Blood-2016-11-753525 |
0.304 |
|
2017 |
Yen K, Travins J, Wang F, David MD, Artin E, Straley K, Padyana A, Gross S, DeLaBarre B, Tobin E, Chen Y, Nagaraja R, Choe S, Jin L, Konteatis Z, et al. AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations. Cancer Discovery. PMID 28193778 DOI: 10.1158/2159-8290.Cd-16-1034 |
0.317 |
|
2014 |
Ulanet DB, Couto K, Jha A, Choe S, Wang A, Woo HK, Steadman M, DeLaBarre B, Gross S, Driggers E, Dorsch M, Hurov JB. Mesenchymal phenotype predisposes lung cancer cells to impaired proliferation and redox stress in response to glutaminase inhibition. Plos One. 9: e115144. PMID 25502225 DOI: 10.1371/Journal.Pone.0115144 |
0.316 |
|
2014 |
DeLaBarre B, Hurov J, Cianchetta G, Murray S, Dang L. Action at a distance: allostery and the development of drugs to target cancer cell metabolism. Chemistry & Biology. 21: 1143-61. PMID 25237859 DOI: 10.1016/J.Chembiol.2014.08.007 |
0.319 |
|
2014 |
Davis MI, Gross S, Shen M, Straley KS, Pragani R, Lea WA, Popovici-Muller J, DeLaBarre B, Artin E, Thorne N, Auld DS, Li Z, Dang L, Boxer MB, Simeonov A. Biochemical, cellular, and biophysical characterization of a potent inhibitor of mutant isocitrate dehydrogenase IDH1. The Journal of Biological Chemistry. 289: 13717-25. PMID 24668804 DOI: 10.1074/Jbc.M113.511030 |
0.339 |
|
2014 |
DeLaBarre B, Wang F, Travins J, Gross S, Artin E, Dang L, Biller S, Yen K. Structural Biology of Mutant IDH2 Inhibition Acta Crystallographica Section a Foundations and Advances. 70: C799-C799. DOI: 10.1107/S2053273314092006 |
0.431 |
|
2013 |
Wang F, Travins J, DeLaBarre B, Penard-Lacronique V, Schalm S, Hansen E, Straley K, Kernytsky A, Liu W, Gliser C, Yang H, Gross S, Artin E, Saada V, Mylonas E, et al. Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation. Science (New York, N.Y.). 340: 622-6. PMID 23558173 DOI: 10.1126/Science.1234769 |
0.426 |
|
2013 |
Kung C, Hixon J, Kosinski P, Histen G, Hill C, Si Y, Kernytsky A, Chen Y, DeLaBarre B, Clasquin M, Ho H, Cossor FI, Neufeld EJ, Salituro F, Popovici-Muller J, et al. Small Molecule Activation Of Pyruvate Kinase Normalizes Metabolic Activity In Red Cells From Patients With Pyruvate Kinase Deficiency-Associated Hemolytic Anemia Blood. 122: 2180-2180. DOI: 10.1182/Blood.V122.21.2180.2180 |
0.373 |
|
2013 |
Wang F, Travins J, DeLaBarre B, Penard-Lacronique V, Schalm S, Hansen E, Straley K, Kernytsky A, Liu W, Gliser C, Yang H, Gross S, Artin E, Saada V, Mylonas E, et al. Abstract PL02-04: IDH mutations and tumorigenicity. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-Pl02-04 |
0.333 |
|
2012 |
Kung C, Hixon J, Choe S, Marks K, Gross S, Murphy E, DeLaBarre B, Cianchetta G, Sethumadhavan S, Wang X, Yan S, Gao Y, Fang C, Wei W, Jiang F, et al. Small molecule activation of PKM2 in cancer cells induces serine auxotrophy. Chemistry & Biology. 19: 1187-98. PMID 22999886 DOI: 10.1016/J.Chembiol.2012.07.021 |
0.323 |
|
2012 |
Delabarre B, Hurov J, Gross S. Abstract 3237: XRay structure of human glutaminase in complex with BPTES and analysis of BPTES-resistant mutants Cancer Research. 72: 3237-3237. DOI: 10.1158/1538-7445.Am2012-3237 |
0.38 |
|
2011 |
DeLaBarre B, Gross S, Fang C, Gao Y, Jha A, Jiang F, Song J J, Wei W, Hurov JB. Full-length human glutaminase in complex with an allosteric inhibitor. Biochemistry. 50: 10764-70. PMID 22049910 DOI: 10.1021/Bi201613D |
0.408 |
|
2007 |
Anderson MJ, DeLabarre B, Raghunathan A, Palsson BO, Brunger AT, Quake SR. Crystal structure of a hyperactive Escherichia coli glycerol kinase mutant Gly230 --> Asp obtained using microfluidic crystallization devices. Biochemistry. 46: 5722-31. PMID 17441732 DOI: 10.1021/Bi700096P |
0.408 |
|
2006 |
DeLaBarre B, Christianson JC, Kopito RR, Brunger AT. Central pore residues mediate the p97/VCP activity required for ERAD. Molecular Cell. 22: 451-62. PMID 16713576 DOI: 10.1016/J.Molcel.2006.03.036 |
0.34 |
|
2005 |
DeLaBarre B, Brunger AT. Nucleotide dependent motion and mechanism of action of p97/VCP. Journal of Molecular Biology. 347: 437-52. PMID 15740751 DOI: 10.1016/J.Jmb.2005.01.060 |
0.351 |
|
2003 |
DeLaBarre B, Brunger AT. Complete structure of p97/valosin-containing protein reveals communication between nucleotide domains. Nature Structural Biology. 10: 856-63. PMID 12949490 DOI: 10.1038/Nsb972 |
0.384 |
|
2002 |
Rouiller I, DeLaBarre B, May AP, Weis WI, Brunger AT, Milligan RA, Wilson-Kubalek EM. Conformational changes of the multifunction p97 AAA ATPase during its ATPase cycle. Nature Structural Biology. 9: 950-7. PMID 12434150 DOI: 10.1038/Nsb872 |
0.304 |
|
2000 |
DeLaBarre B, Thompson PR, Wright GD, Berghuis AM. Crystal structures of homoserine dehydrogenase suggest a novel catalytic mechanism for oxidoreductases. Nature Structural Biology. 7: 238-44. PMID 10700284 DOI: 10.1038/73359 |
0.538 |
|
1998 |
DeLaBarre B, Jacques SL, Pratt CE, Ruth DA, Wright GD, Berghuis AM. Crystallization and preliminary X-ray diffraction studies of homoserine dehydrogenase from Saccharomyces cerevisiae. Acta Crystallographica. Section D, Biological Crystallography. 54: 413-5. PMID 9761913 DOI: 10.1107/S0907444997011967 |
0.504 |
|
1996 |
DeLaBarre B, Wright GD, Berghuis AM. Crystallographic studies of homoserine dehydrogenase for the design of novel antifungal agents Acta Crystallographica Section a Foundations of Crystallography. 52: C99-C99. DOI: 10.1107/S0108767396095153 |
0.469 |
|
Show low-probability matches. |