Sandra B. Gabelli, Ph.D. - Publications

Medicine, Oncology, Biophysics and Biophysical Chemistry Johns Hopkins University School of Medicine, Baltimore, MD, United States 
PI3K, Nudix, Sodium Voltage Gated Channels, FPPS, structural biology

68 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Miller MS, Douglass J, Hwang MS, Skora AD, Murphy M, Papadopoulos N, Kinzler KW, Vogelstein B, Zhou S, Gabelli SB. An engineered antibody fragment targeting mutant β-catenin via Major Histocompatibility Complex I neoantigen presentation. The Journal of Biological Chemistry. PMID 31690625 DOI: 10.1074/jbc.RA119.010251  0.88
2019 Thirawatananond P, McPherson RL, Malhi J, Nathan S, Lambrecht MJ, Brichacek M, Hergenrother PJ, Leung AKL, Gabelli SB. Structural analyses of NudT16-ADP-ribose complexes direct rational design of mutants with improved processing of poly(ADP-ribosyl)ated proteins. Scientific Reports. 9: 5940. PMID 30976021 DOI: 10.1038/s41598-019-39491-w  0.72
2019 Yoder JB, Ben-Johny M, Farinelli F, Srinivasan L, Shoemaker SR, Tomaselli GF, Gabelli SB, Amzel LM. Ca-dependent regulation of sodium channels Na1.4 and Na1.5 is controlled by the post-IQ motif. Nature Communications. 10: 1514. PMID 30944319 DOI: 10.1038/s41467-019-09570-7  1
2019 Miller MS, Thompson PE, Gabelli SB. Structural Determinants of Isoform Selectivity in PI3K Inhibitors. Biomolecules. 9. PMID 30813656 DOI: 10.3390/biom9030082  0.8
2019 Miller MS, Maheshwari S, Shi W, Gao Y, Chu N, Soares AS, Cole PA, Amzel LM, Fuchs MR, Jakoncic J, Gabelli SB. Getting the Most Out of Your Crystals: Data Collection at the New High-Flux, Microfocus MX Beamlines at NSLS-II. Molecules (Basel, Switzerland). 24. PMID 30704096 DOI: 10.3390/molecules24030496  1
2018 Maheshwari S, Shimokawa C, Rudzka K, Kline CD, Eipper BA, Mains RE, Gabelli SB, Blackburn N, Amzel LM. Effects of copper occupancy on the conformational landscape of peptidylglycine α-hydroxylating monooxygenase. Communications Biology. 1: 74. PMID 30271955 DOI: 10.1038/s42003-018-0082-y  1
2018 Chu N, Salguero AL, Liu AZ, Chen Z, Dempsey DR, Ficarro SB, Alexander WM, Marto JA, Li Y, Amzel LM, Gabelli SB, Cole PA. Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis. Cell. PMID 30078705 DOI: 10.1016/j.cell.2018.07.003  1
2018 Banerjee R, Yoder JB, Yue DT, Amzel LM, Tomaselli GF, Gabelli SB, Ben-Johny M. Bilobal architecture is a requirement for calmodulin signaling to Ca1.3 channels. Proceedings of the National Academy of Sciences of the United States of America. PMID 29531055 DOI: 10.1073/pnas.1716381115  1
2018 Shumar SA, Kerr EW, Geldenhuys WJ, Montgomery GE, Fagone P, Thirawatananond P, Saavedra H, Gabelli SB, Leonardi R. Nudt19 is a renal CoA diphosphohydrolase with biochemical and regulatory properties that are distinct from the hepatic Nudt7 isoform. The Journal of Biological Chemistry. PMID 29378847 DOI: 10.1074/jbc.RA117.001358  0.72
2017 Nakamura H, Lee AA, Afshar AS, Watanabe S, Rho E, Razavi S, Suarez A, Lin YC, Tanigawa M, Huang B, DeRose R, Bobb D, Hong W, Gabelli SB, Goutsias J, et al. Intracellular production of hydrogels and synthetic RNA granules by multivalent molecular interactions. Nature Materials. PMID 29115293 DOI: 10.1038/nmat5006  0.64
2017 Chatterjee S, Lesniak WG, Miller MS, Lisok A, Sikorska E, Wharram B, Kumar D, Gabrielson M, Pomper MG, Gabelli SB, Nimmagadda S. Corrigendum to "Rapid PD-L1 detection in tumors with PET using a highly specific peptide" [Biochemical and Biophysical Research Communications 483/1 (2017) 258-263]. Biochemical and Biophysical Research Communications. PMID 28801167 DOI: 10.1016/j.bbrc.2017.08.001  0.8
2017 Maheshwari S, Miller MS, O'Meally R, Cole RN, Amzel LM, Gabelli SB. Kinetic and structural analyses reveal residues in phosphoinositide 3-kinase α that are critical for catalysis and substrate recognition. The Journal of Biological Chemistry. PMID 28676499 DOI: 10.1074/jbc.M116.772426  1
2017 Chen Z, Jiang H, Xu W, Li X, Dempsey DR, Zhang X, Devreotes P, Wolberger C, Amzel LM, Gabelli SB, Cole PA. A Tunable Brake for HECT Ubiquitin Ligases. Molecular Cell. 66: 345-357.e6. PMID 28475870 DOI: 10.1016/j.molcel.2017.03.020  1
2017 Miller MS, Maheshwari S, McRobb FM, Kinzler KW, Amzel LM, Vogelstein B, Gabelli SB. Identification of allosteric binding sites for PI3Kα oncogenic mutant specific inhibitor design. Bioorganic & Medicinal Chemistry. PMID 28129991 DOI: 10.1016/j.bmc.2017.01.012  1
2016 Chatterjee S, Lesniak WG, Miller MS, Lisok A, Sikorska E, Wharram B, Kumar D, Gabrielson M, Pomper MG, Gabelli SB, Nimmagadda S. Rapid PD-L1 detection in tumors with PET using a highly specific peptide. Biochemical and Biophysical Research Communications. PMID 28025143 DOI: 10.1016/j.bbrc.2016.12.156  0.8
2016 O'Handley SF, Thirawatananond P, Kang LW, Cunningham JE, Leyva JA, Amzel LM, Gabelli SB. Kinetic and mutational studies of the adenosine diphosphate ribose hydrolase from Mycobacterium tuberculosis. Journal of Bioenergetics and Biomembranes. PMID 27683242 DOI: 10.1007/s10863-016-9681-9  1
2015 Daniels CM, Thirawatananond P, Ong SE, Gabelli SB, Leung AK. Nudix hydrolases degrade protein-conjugated ADP-ribose. Scientific Reports. 5: 18271. PMID 26669448 DOI: 10.1038/srep18271  1
2015 de la Peña AH, Suarez A, Duong-Ly KC, Schoeffield AJ, Pizarro-Dupuy MA, Zarr M, Pineiro SA, Amzel LM, Gabelli SB. Structural and Enzymatic Characterization of a Nucleoside Diphosphate Sugar Hydrolase from Bdellovibrio bacteriovorus. Plos One. 10: e0141716. PMID 26524597 DOI: 10.1371/journal.pone.0141716  1
2015 Gabelli SB, Yoder JB, Tomaselli GF, Amzel LM. Calmodulin and Ca(2+) control of voltage gated Na(+) channels. Channels (Austin, Tex.). 0. PMID 26218606 DOI: 10.1080/19336950.2015.1075677  0.64
2015 Skora AD, Douglass J, Hwang MS, Tam AJ, Blosser RL, Gabelli SB, Cao J, Diaz LA, Papadopoulos N, Kinzler KW, Vogelstein B, Zhou S. Generation of MANAbodies specific to HLA-restricted epitopes encoded by somatically mutated genes. Proceedings of the National Academy of Sciences of the United States of America. PMID 26216968 DOI: 10.1073/pnas.1511996112  1
2015 Echeverria I, Liu Y, Gabelli SB, Amzel LM. Oncogenic mutations weaken the interactions that stabilize the p110α-p85α heterodimer in phosphatidylinositol 3-kinase α. The Febs Journal. 282: 3528-42. PMID 26122737 DOI: 10.1111/febs.13365  1
2015 Duong-Ly KC, Gabelli SB. Affinity Purification of a Recombinant Protein Expressed as a Fusion with the Maltose-Binding Protein (MBP) Tag. Methods in Enzymology. 559: 17-26. PMID 26096500 DOI: 10.1016/bs.mie.2014.11.004  1
2015 Wolff KA, de la Peña AH, Nguyen HT, Pham TH, Amzel LM, Gabelli SB, Nguyen L. A redox regulatory system critical for mycobacterial survival in macrophages and biofilm development. Plos Pathogens. 11: e1004839. PMID 25884716 DOI: 10.1371/journal.ppat.1004839  1
2014 Gabelli SB, Boto A, Kuhns VH, Bianchet MA, Farinelli F, Aripirala S, Yoder J, Jakoncic J, Tomaselli GF, Amzel LM. Regulation of the NaV1.5 cytoplasmic domain by calmodulin. Nature Communications. 5: 5126. PMID 25370050 DOI: 10.1038/ncomms6126  1
2014 Gabelli SB, Echeverria I, Alexander M, Duong-Ly KC, Chaves-Moreira D, Brower ET, Vogelstein B, Amzel LM. Activation of PI3Kα by physiological effectors and by oncogenic mutations: structural and dynamic effects. Biophysical Reviews. 6: 89-95. PMID 25309634 DOI: 10.1007/s12551-013-0131-1  1
2014 Miller MS, Schmidt-Kittler O, Bolduc DM, Brower ET, Chaves-Moreira D, Allaire M, Kinzler KW, Jennings IG, Thompson PE, Cole PA, Amzel LM, Vogelstein B, Gabelli SB. Structural basis of nSH2 regulation and lipid binding in PI3Kα. Oncotarget. 5: 5198-208. PMID 25105564  1
2014 Duong-Ly KC, Gabelli SB. Explanatory chapter: troubleshooting protein expression: what to do when the protein is not soluble. Methods in Enzymology. 541: 231-47. PMID 24674075 DOI: 10.1016/B978-0-12-420119-4.00018-5  1
2014 Duong-Ly KC, Gabelli SB. Explanatory chapter: troubleshooting recombinant protein expression: general. Methods in Enzymology. 541: 209-29. PMID 24674074 DOI: 10.1016/B978-0-12-420119-4.00017-3  1
2014 Duong-Ly KC, Gabelli SB. Gel filtration chromatography (size exclusion chromatography) of proteins. Methods in Enzymology. 541: 105-14. PMID 24674066 DOI: 10.1016/B978-0-12-420119-4.00009-4  1
2014 Duong-Ly KC, Gabelli SB. Using ion exchange chromatography to purify a recombinantly expressed protein. Methods in Enzymology. 541: 95-103. PMID 24674065 DOI: 10.1016/B978-0-12-420119-4.00008-2  1
2014 Duong-Ly KC, Gabelli SB. Salting out of proteins using ammonium sulfate precipitation. Methods in Enzymology. 541: 85-94. PMID 24674064 DOI: 10.1016/B978-0-12-420119-4.00007-0  1
2014 Aripirala S, Gonzalez-Pacanowska D, Oldfield E, Kaiser M, Amzel LM, Gabelli SB. Structural and thermodynamic basis of the inhibition of Leishmania major farnesyl diphosphate synthase by nitrogen-containing bisphosphonates. Acta Crystallographica. Section D, Biological Crystallography. 70: 802-10. PMID 24598749 DOI: 10.1107/S1399004713033221  1
2013 Bolduc D, Rahdar M, Tu-Sekine B, Sivakumaren SC, Raben D, Amzel LM, Devreotes P, Gabelli SB, Cole P. Phosphorylation-mediated PTEN conformational closure and deactivation revealed with protein semisynthesis. Elife. 2: e00691. PMID 23853711 DOI: 10.7554/eLife.00691  1
2013 Duong-Ly KC, Woo HN, Dunn CA, Xu W, Babič A, Bessman MJ, Amzel LM, Gabelli SB. A UDP-X diphosphatase from Streptococcus pneumoniae hydrolyzes precursors of peptidoglycan biosynthesis. Plos One. 8: e64241. PMID 23691178 DOI: 10.1371/journal.pone.0064241  1
2013 Zhang F, Bhat S, Gabelli SB, Chen X, Miller MS, Nacev BA, Cheng YL, Meyers DJ, Tenney K, Shim JS, Crews P, Amzel LM, Ma D, Liu JO. Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells Journal of Medicinal Chemistry. 56: 3996-4016. PMID 23634668 DOI: 10.1021/jm400227z  1
2013 Zhang P, Yang X, Zhang F, Gabelli SB, Wang R, Zhang Y, Bhat S, Chen X, Furlani M, Amzel LM, Liu JO, Ma D. Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1. Bioorganic & Medicinal Chemistry. 21: 2600-17. PMID 23507151 DOI: 10.1016/j.bmc.2013.02.023  1
2012 Aripirala S, Szajnman SH, Jakoncic J, Rodriguez JB, Docampo R, Gabelli SB, Amzel LM. Design, synthesis, calorimetry, and crystallographic analysis of 2-alkylaminoethyl-1,1-bisphosphonates as inhibitors of Trypanosoma cruzi farnesyl diphosphate synthase. Journal of Medicinal Chemistry. 55: 6445-54. PMID 22715997 DOI: 10.1021/jm300425y  1
2011 Boto AN, Xu W, Jakoncic J, Pannuri A, Romeo T, Bessman MJ, Gabelli SB, Amzel LM. Structural studies of the Nudix GDP-mannose hydrolase from E. coli reveals a new motif for mannose recognition. Proteins. 79: 2455-66. PMID 21638333 DOI: 10.1002/prot.23069  1
2011 Duong-Ly KC, Gabelli SB, Xu W, Dunn CA, Schoeffield AJ, Bessman MJ, Amzel LM. The Nudix hydrolase CDP-chase, a CDP-choline pyrophosphatase, is an asymmetric dimer with two distinct enzymatic activities. Journal of Bacteriology. 193: 3175-85. PMID 21531795 DOI: 10.1128/JB.00089-11  1
2011 Gabelli SB, Duong-Ly KC, Brower ET, Amzel LM. Capitalizing on tumor genotyping: towards the design of mutation specific inhibitors of phosphoinsitide-3-kinase. Advances in Enzyme Regulation. 51: 273-9. PMID 21035489 DOI: 10.1016/j.advenzreg.2010.09.013  1
2010 Schmidt-Kittler O, Zhu J, Yang J, Liu G, Hendricks W, Lengauer C, Gabelli SB, Kinzler KW, Vogelstein B, Huso DL, Zhou S. PI3Kα inhibitors that inhibit metastasis. Oncotarget. 1: 339-348. PMID 21179398  1
2010 Messing SA, Gabelli SB, Echeverria I, Vogel JT, Guan JC, Tan BC, Klee HJ, McCarty DR, Amzel LM. Structural insights into maize viviparous14, a key enzyme in the biosynthesis of the phytohormone abscisic acid. The Plant Cell. 22: 2970-80. PMID 20884803 DOI: 10.1105/tpc.110.074815  1
2010 Mohan S, Tse CM, Gabelli SB, Sarker R, Cha B, Fahie K, Nadella M, Zachos NC, Tu-Sekine B, Raben D, Amzel LM, Donowitz M. NHE3 activity is dependent on direct phosphoinositide binding at the N terminus of its intracellular cytosolic region. The Journal of Biological Chemistry. 285: 34566-78. PMID 20736165 DOI: 10.1074/jbc.M110.165712  1
2010 Gabelli SB, Huang CH, Mandelker D, Schmidt-Kittler O, Vogelstein B, Amzel LM. Structural effects of oncogenic PI3Kα mutations Current Topics in Microbiology and Immunology. 347: 43-53. PMID 20593314 DOI: 10.1007/82-2010-53  1
2010 Barrila J, Gabelli SB, Bacha U, Amzel LM, Freire E. Mutation of Asn28 disrupts the dimerization and enzymatic activity of SARS 3CL(pro) . Biochemistry. 49: 4308-17. PMID 20420403 DOI: 10.1021/bi1002585  1
2010 Gabelli SB, Mandelker D, Schmidt-Kittler O, Vogelstein B, Amzel LM. Somatic mutations in PI3Kα: Structural basis for enzyme activation and drug design Biochimica Et Biophysica Acta - Proteins and Proteomics. 1804: 533-540. PMID 19962457 DOI: 10.1016/j.bbapap.2009.11.020  1
2010 Huang CH, Gabelli SB, Oldfield E, Amzel LM. Binding of nitrogen-containing bisphosphonates (N-BPs) to the Trypanosoma cruzi farnesyl diphosphate synthase homodimer. Proteins. 78: 888-99. PMID 19876942 DOI: 10.1002/prot.22614  1
2009 Mandelker D, Gabelli SB, Schmidt-Kittler O, Zhu J, Cheong I, Huang CH, Kinzler KW, Vogelstein B, Amzel LM. A frequent kinase domain mutation that changes the interaction between PI3Kα and the membrane Proceedings of the National Academy of Sciences of the United States of America. 106: 16996-17001. PMID 19805105 DOI: 10.1073/pnas.0908444106  1
2009 Messing SA, Gabelli SB, Liu Q, Celesnik H, Belasco JG, Piñeiro SA, Amzel LM. Structure and biological function of the RNA pyrophosphohydrolase BdRppH from Bdellovibrio bacteriovorus. Structure (London, England : 1993). 17: 472-81. PMID 19278661 DOI: 10.1016/j.str.2008.12.022  1
2008 Steyert SR, Messing SA, Amzel LM, Gabelli SB, Piñeiro SA. Identification of Bdellovibrio bacteriovorus HD100 Bd0714 as a Nudix dGTPase. Journal of Bacteriology. 190: 8215-9. PMID 18931106 DOI: 10.1128/JB.01009-08  1
2008 Amzel LM, Huang CH, Mandelker D, Lengauer C, Gabelli SB, Vogelstein B. Structural comparisons of class I phosphoinositide 3-kinases Nature Reviews Cancer. 8: 665-669. PMID 18633356 DOI: 10.1038/nrc2443  1
2008 Bacha U, Barrila J, Gabelli SB, Kiso Y, Mario Amzel L, Freire E. Development of broad-spectrum halomethyl ketone inhibitors against coronavirus main protease 3CL(pro). Chemical Biology & Drug Design. 72: 34-49. PMID 18611220 DOI: 10.1111/j.1747-0285.2008.00679.x  1
2008 Huang CH, Mandelker D, Gabelli SB, Amzel LM. Insights into the oncogenic effects of PIK3CA mutations from the structure of p110alpha/p85alpha. Cell Cycle (Georgetown, Tex.). 7: 1151-6. PMID 18418043  1
2007 Huang CH, Mandelker D, Schmidt-Kittler O, Samuels Y, Velculescu VE, Kinzler KW, Vogelstein B, Gabelli SB, Amzel LM. The structure of a human p110α/p85α complex elucidates the effects of oncogenic PI3Kα mutations Science. 318: 1744-1748. PMID 18079394 DOI: 10.1126/science.1150799  1
2007 Gabelli SB, Bianchet MA, Xu W, Dunn CA, Niu ZD, Amzel LM, Bessman MJ. Structure and function of the E. coli dihydroneopterin triphosphate pyrophosphatase: a Nudix enzyme involved in folate biosynthesis. Structure (London, England : 1993). 15: 1014-22. PMID 17698004 DOI: 10.1016/j.str.2007.06.018  1
2006 Gabelli SB, Azurmendi HF, Bianchet MA, Amzel LM, Mildvan AS. X-ray, NMR, and mutational studies of the catalytic cycle of the GDP-mannose mannosyl hydrolase reaction. Biochemistry. 45: 11290-303. PMID 16981689 DOI: 10.1021/bi061239g  1
2006 Gabelli SB, McLellan JS, Montalvetti A, Oldfield E, Docampo R, Amzel LM. Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: implications for drug design. Proteins. 62: 80-8. PMID 16288456 DOI: 10.1002/prot.20754  1
2006 Mildvan AS, Xia Z, Azurmendi HF, Legler PM, Balfour MR, Lairson LL, Withers SG, Gabelli SB, Bianchet MA, Amzel LM. Hydrogen bonding in the mechanism of GDP-mannose mannosyl hydrolase Journal of Molecular Structure. 790: 160-167. DOI: 10.1016/j.molstruc.2005.09.024  1
2005 Nadella M, Bianchet MA, Gabelli SB, Barrila J, Amzel LM. Structure and activity of the axon guidance protein MICAL. Proceedings of the National Academy of Sciences of the United States of America. 102: 16830-5. PMID 16275926 DOI: 10.1073/pnas.0504838102  1
2005 Coblitz B, Shikano S, Wu M, Gabelli SB, Cockrell LM, Spieker M, Hanyu Y, Fu H, Amzel LM, Li M. C-terminal recognition by 14-3-3 proteins for surface expression of membrane receptors. The Journal of Biological Chemistry. 280: 36263-72. PMID 16123035 DOI: 10.1074/jbc.M507559200  1
2005 Xia Z, Azurmendi HF, Lairson LL, Withers SG, Gabelli SB, Bianchet MA, Amzel LM, Mildvan AS. Mutational, structural, and kinetic evidence for a dissociative mechanism in the GDP-mannose mannosyl hydrolase reaction. Biochemistry. 44: 8989-97. PMID 15966723 DOI: 10.1021/bi050583v  1
2005 Mildvan AS, Xia Z, Azurmendi HF, Saraswat V, Legler PM, Massiah MA, Gabelli SB, Bianchet MA, Kang LW, Amzel LM. Structures and mechanisms of Nudix hydrolases. Archives of Biochemistry and Biophysics. 433: 129-43. PMID 15581572 DOI: 10.1016/  1
2004 Gabelli SB, Bianchet MA, Azurmendi HF, Xia Z, Sarawat V, Mildvan AS, Amzel LM. Structure and mechanism of GDP-mannose glycosyl hydrolase, a Nudix enzyme that cleaves at carbon instead of phosphorus. Structure (London, England : 1993). 12: 927-35. PMID 15274914 DOI: 10.1016/j.str.2004.03.028  1
2003 Kang LW, Gabelli SB, Cunningham JE, O'Handley SF, Amzel LM. Structure and mechanism of MT-ADPRase, a nudix hydrolase from Mycobacterium tuberculosis. Structure (London, England : 1993). 11: 1015-23. PMID 12906832 DOI: 10.1016/S0969-2126(03)00154-0  1
2003 Kang LW, Gabelli SB, Bianchet MA, Xu WL, Bessman MJ, Amzel LM. Structure of a coenzyme A pyrophosphatase from Deinococcus radiodurans: a member of the Nudix family. Journal of Bacteriology. 185: 4110-8. PMID 12837785 DOI: 10.1128/JB.185.14.4110-4118.2003  1
2003 Cho HS, Mason K, Ramyar KX, Stanley AM, Gabelli SB, Denney DW, Leahy DJ. Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab. Nature. 421: 756-60. PMID 12610629 DOI: 10.1038/nature01392  1
2002 Gabelli SB, Bianchet MA, Ohnishi Y, Ichikawa Y, Bessman MJ, Amzel LM. Mechanism of the Escherichia coli ADP-ribose pyrophosphatase, a Nudix hydrolase. Biochemistry. 41: 9279-85. PMID 12135348 DOI: 10.1021/bi0259296  1
2001 Gabelli SB, Bianchet MA, Bessman MJ, Amzel LM. The structure of ADP-ribose pyrophosphatase reveals the structural basis for the versatility of the Nudix family. Nature Structural Biology. 8: 467-72. PMID 11323725 DOI: 10.1038/87647  1
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