Year |
Citation |
Score |
2012 |
Di L, Keefer C, Scott DO, Strelevitz TJ, Chang G, Bi YA, Lai Y, Duckworth J, Fenner K, Troutman MD, Obach RS. Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design. European Journal of Medicinal Chemistry. 57: 441-8. PMID 22840492 DOI: 10.1016/j.ejmech.2012.06.043 |
0.32 |
|
2011 |
Di L, Whitney-Pickett C, Umland JP, Zhang H, Zhang X, Gebhard DF, Lai Y, Federico JJ, Davidson RE, Smith R, Reyner EL, Lee C, Feng B, Rotter C, Varma MV, ... ... Troutman MD, et al. Development of a new permeability assay using low-efflux MDCKII cells. Journal of Pharmaceutical Sciences. 100: 4974-85. PMID 21766308 DOI: 10.1002/jps.22674 |
0.341 |
|
2010 |
Cook JA, Feng B, Fenner KS, Kempshall S, Liu R, Rotter C, Smith DA, Troutman MD, Ullah M, Lee CA. Refining the in vitro and in vivo critical parameters for P-glycoprotein, [I]/IC50 and [I2]/IC50, that allow for the exclusion of drug candidates from clinical digoxin interaction studies. Molecular Pharmaceutics. 7: 398-411. PMID 20025245 DOI: 10.1021/mp900174z |
0.336 |
|
2009 |
Kalgutkar AS, Frederick KS, Chupka J, Feng B, Kempshall S, Mireles RJ, Fenner KS, Troutman MD. N-(3,4-dimethoxyphenethyl)-4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2[1H]-yl)-6,7-dimethoxyquinazolin-2-amine (CP-100,356) as a "chemical knock-out equivalent" to assess the impact of efflux transporters on oral drug absorption in the rat. Journal of Pharmaceutical Sciences. 98: 4914-27. PMID 19373887 DOI: 10.1002/jps.21756 |
0.32 |
|
2009 |
Merzlikine A, Rotter C, Rago B, Poe J, Christoffersen C, Thomas VH, Troutman M, El-Kattan A. Effect of chitosan glutamate, carbomer 974P, and EDTA on the in vitro Caco-2 permeability and oral pharmacokinetic profile of acyclovir in rats. Drug Development and Industrial Pharmacy. 35: 1082-91. PMID 19294548 DOI: 10.1080/03639040902774156 |
0.342 |
|
2009 |
Fenner KS, Troutman MD, Kempshall S, Cook JA, Ware JA, Smith DA, Lee CA. Drug-drug interactions mediated through P-glycoprotein: clinical relevance and in vitro-in vivo correlation using digoxin as a probe drug. Clinical Pharmacology and Therapeutics. 85: 173-81. PMID 18987624 DOI: 10.1038/clpt.2008.195 |
0.333 |
|
2008 |
Feng B, Mills JB, Davidson RE, Mireles RJ, Janiszewski JS, Troutman MD, de Morais SM. In vitro P-glycoprotein assays to predict the in vivo interactions of P-glycoprotein with drugs in the central nervous system. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 268-75. PMID 17962372 DOI: 10.1124/dmd.107.017434 |
0.402 |
|
2006 |
Knight B, Troutman M, Thakker DR. Deconvoluting the effects of P-glycoprotein on intestinal CYP3A: a major challenge. Current Opinion in Pharmacology. 6: 528-32. PMID 16899406 DOI: 10.1016/J.Coph.2006.04.009 |
0.53 |
|
2005 |
Doran A, Obach RS, Smith BJ, Hosea NA, Becker S, Callegari E, Chen C, Chen X, Choo E, Cianfrogna J, Cox LM, Gibbs JP, Gibbs MA, Hatch H, Hop CE, ... ... Troutman M, et al. The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 33: 165-74. PMID 15502009 DOI: 10.1124/Dmd.104.001230 |
0.355 |
|
2003 |
Troutman MD, Thakker DR. Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium. Pharmaceutical Research. 20: 1210-24. PMID 12948019 DOI: 10.1023/A:1025001131513 |
0.641 |
|
2003 |
Troutman MD, Thakker DR. Efflux ratio cannot assess P-glycoprotein-mediated attenuation of absorptive transport: asymmetric effect of P-glycoprotein on absorptive and secretory transport across Caco-2 cell monolayers. Pharmaceutical Research. 20: 1200-9. PMID 12948018 DOI: 10.1023/A:1025049014674 |
0.655 |
|
2003 |
Troutman MD, Thakker DR. Rhodamine 123 requires carrier-mediated influx for its activity as a P-glycoprotein substrate in Caco-2 cells. Pharmaceutical Research. 20: 1192-9. PMID 12948017 DOI: 10.1023/A:1025096930604 |
0.603 |
|
2002 |
Ward PD, Klein RR, Troutman MD, Desai S, Thakker DR. Phospholipase C-gamma modulates epithelial tight junction permeability through hyperphosphorylation of tight junction proteins. The Journal of Biological Chemistry. 277: 35760-5. PMID 12101180 DOI: 10.1074/Jbc.M203134200 |
0.526 |
|
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