Matthew D. Troutman, Ph.D. - Publications

Affiliations: 
2002 University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Pharmacy, Pharmacology

32 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Zhang H, Liu C, Hua W, Ghislain LP, Liu J, Aschenbrenner L, Noell S, Dirico KJ, Lanyon LF, Steppan CM, West M, Arnold DW, Covey TR, Datwani SS, Troutman MD. Acoustic Ejection Mass Spectrometry for High-Throughput Analysis. Analytical Chemistry. PMID 34320311 DOI: 10.1021/acs.analchem.1c01137  0.01
2020 DiRico KJ, Hua W, Liu C, Tucker JW, Ratnayake AS, Flanagan ME, Troutman MD, Noe MC, Zhang H. Ultra-High-Throughput Acoustic Droplet Ejection-Open Port Interface-Mass Spectrometry for Parallel Medicinal Chemistry. Acs Medicinal Chemistry Letters. 11: 1101-1110. PMID 32550988 DOI: 10.1021/Acsmedchemlett.0C00066  1
2020 DiRico KJ, Hua W, Liu C, Tucker JW, Ratnayake AS, Flanagan ME, Troutman MD, Noe MC, Zhang H. Ultra-High-Throughput Acoustic Droplet Ejection-Open Port Interface-Mass Spectrometry for Parallel Medicinal Chemistry Acs Medicinal Chemistry Letters. 11: 1101-1110. DOI: 10.1021/acsmedchemlett.0c00066  0.01
2019 Trapa PE, Troutman MD, Lau TY, Wager TT, Maurer TS, Patel NC, West MA, Umland JP, Carlo AA, Feng B, Liras JL. In vitro-In vivo extrapolation of key transporter activity at the blood-brain barrier. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 30683809 DOI: 10.1124/dmd.118.083279  1
2013 Fu C, Di L, Han X, Soderstrom C, Snyder M, Troutman MD, Obach RS, Zhang H. Aldehyde oxidase 1 (AOX1) in human liver cytosols: quantitative characterization of AOX1 expression level and activity relationship. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 1797-804. PMID 23857892 DOI: 10.1124/Dmd.113.053082  1
2013 Zelesky V, Schneider R, Janiszewski J, Zamora I, Ferguson J, Troutman M. Software automation tools for increased throughput metabolic soft-spot identification in early drug discovery. Bioanalysis. 5: 1165-79. PMID 23721441 DOI: 10.4155/bio.13.89  1
2013 Chen J, Rong F, Shan B, Chen Y, Li Y, Yu H, Chen L, Kuang T, Li S, Du J, Ai C, Li J, Li X, Shi C, Jiang Z, ... ... Troutman M, et al. Synthesis of 12-membered macrocyclic templates and library analogs for PPI Tetrahedron Letters. 54: 3298-3301. DOI: 10.1016/j.tetlet.2013.04.058  1
2012 Di L, Keefer C, Scott DO, Strelevitz TJ, Chang G, Bi YA, Lai Y, Duckworth J, Fenner K, Troutman MD, Obach RS. Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design. European Journal of Medicinal Chemistry. 57: 441-8. PMID 22840492 DOI: 10.1016/j.ejmech.2012.06.043  1
2012 Janiszewski J, Schneider R, Kapinos B, West M, Funk C, Federico J, Umland J, Piotrowski M, Mitchell W, Zhang H, Zelesky V, Gobey J, Whalen K, Liston T, Troutman M. Development of a high-speed, multiplexed sample-delivery instrument for LC-MS/MS bioanalysis. Bioanalysis. 4: 1039-56. PMID 22612685 DOI: 10.4155/Bio.12.87  1
2011 Di L, Whitney-Pickett C, Umland JP, Zhang H, Zhang X, Gebhard DF, Lai Y, Federico JJ, Davidson RE, Smith R, Reyner EL, Lee C, Feng B, Rotter C, Varma MV, ... ... Troutman MD, et al. Development of a new permeability assay using low-efflux MDCKII cells. Journal of Pharmaceutical Sciences. 100: 4974-85. PMID 21766308 DOI: 10.1002/jps.22674  1
2011 Di L, Umland JP, Chang G, Huang Y, Lin Z, Scott DO, Troutman MD, Liston TE. Species independence in brain tissue binding using brain homogenates. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 39: 1270-7. PMID 21474681 DOI: 10.1124/dmd.111.038778  1
2010 Wager TT, Chandrasekaran RY, Hou X, Troutman MD, Verhoest PR, Villalobos A, Will Y. Defining desirable central nervous system drug space through the alignment of molecular properties, in vitro ADME, and safety attributes. Acs Chemical Neuroscience. 1: 420-34. PMID 22778836 DOI: 10.1021/cn100007x  1
2010 Varma MV, Obach RS, Rotter C, Miller HR, Chang G, Steyn SJ, El-Kattan A, Troutman MD. Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of Medicinal Chemistry. 53: 1098-108. PMID 20070106 DOI: 10.1021/jm901371v  1
2010 Cook JA, Feng B, Fenner KS, Kempshall S, Liu R, Rotter C, Smith DA, Troutman MD, Ullah M, Lee CA. Refining the in vitro and in vivo critical parameters for P-glycoprotein, [I]/IC50 and [I2]/IC50, that allow for the exclusion of drug candidates from clinical digoxin interaction studies. Molecular Pharmaceutics. 7: 398-411. PMID 20025245 DOI: 10.1021/mp900174z  1
2009 Varma MV, Feng B, Obach RS, Troutman MD, Chupka J, Miller HR, El-Kattan A. Physicochemical determinants of human renal clearance. Journal of Medicinal Chemistry. 52: 4844-52. PMID 19445515 DOI: 10.1021/jm900403j  1
2009 Kalgutkar AS, Frederick KS, Chupka J, Feng B, Kempshall S, Mireles RJ, Fenner KS, Troutman MD. N-(3,4-dimethoxyphenethyl)-4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2[1H]-yl)-6,7-dimethoxyquinazolin-2-amine (CP-100,356) as a "chemical knock-out equivalent" to assess the impact of efflux transporters on oral drug absorption in the rat. Journal of Pharmaceutical Sciences. 98: 4914-27. PMID 19373887 DOI: 10.1002/jps.21756  1
2009 Merzlikine A, Rotter C, Rago B, Poe J, Christoffersen C, Thomas VH, Troutman M, El-Kattan A. Effect of chitosan glutamate, carbomer 974P, and EDTA on the in vitro Caco-2 permeability and oral pharmacokinetic profile of acyclovir in rats. Drug Development and Industrial Pharmacy. 35: 1082-91. PMID 19294548 DOI: 10.1080/03639040902774156  1
2009 Zhou L, Schmidt K, Nelson FR, Zelesky V, Troutman MD, Feng B. The effect of breast cancer resistance protein and P-glycoprotein on the brain penetration of flavopiridol, imatinib mesylate (Gleevec), prazosin, and 2-methoxy-3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)propanoic acid (PF-407288) in mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 946-55. PMID 19225039 DOI: 10.1124/dmd.108.024489  1
2009 Fenner KS, Troutman MD, Kempshall S, Cook JA, Ware JA, Smith DA, Lee CA. Drug-drug interactions mediated through P-glycoprotein: clinical relevance and in vitro-in vivo correlation using digoxin as a probe drug. Clinical Pharmacology and Therapeutics. 85: 173-81. PMID 18987624 DOI: 10.1038/clpt.2008.195  1
2008 Hop CE, Cole MJ, Davidson RE, Duignan DB, Federico J, Janiszewski JS, Jenkins K, Krueger S, Lebowitz R, Liston TE, Mitchell W, Snyder M, Steyn SJ, Soglia JR, Taylor C, Troutman MD, et al. High throughput ADME screening: practical considerations, impact on the portfolio and enabler of in silico ADME models. Current Drug Metabolism. 9: 847-53. PMID 18991580 DOI: 10.2174/138920008786485092  1
2008 Faessel HM, Burstein AH, Troutman MD, Willavize SA, Rohrbacher KD, Clark DJ. Lack of a pharmacokinetic interaction between a new smoking cessation therapy, varenicline, and digoxin in adult smokers. European Journal of Clinical Pharmacology. 64: 1101-9. PMID 18661125 DOI: 10.1007/s00228-008-0530-6  1
2008 Gao H, Yao L, Mathieu HW, Zhang Y, Maurer TS, Troutman MD, Scott DO, Ruggeri RB, Lin J. In silico modeling of nonspecific binding to human liver microsomes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 2130-5. PMID 18606744 DOI: 10.1124/dmd.107.020131  1
2008 Joelsson D, Moravec P, Troutman M, Pigeon J, DePhillips P. Optimizing ELISAs for precision and robustness using laboratory automation and statistical design of experiments Journal of Immunological Methods. 337: 35-41. PMID 18572188 DOI: 10.1016/j.jim.2008.05.012  1
2008 Feng B, Mills JB, Davidson RE, Mireles RJ, Janiszewski JS, Troutman MD, de Morais SM. In vitro P-glycoprotein assays to predict the in vivo interactions of P-glycoprotein with drugs in the central nervous system. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 268-75. PMID 17962372 DOI: 10.1124/dmd.107.017434  1
2008 Stoner CL, Troutman MD, Laverty CE. Pharmacokinetics and ADME optimization in drug discovery Cancer Drug Design and Discovery. 131-153. DOI: 10.1016/B978-012369448-5.50009-4  1
2007 Singleton DH, Boyd H, Steidl-Nichols JV, Deacon M, Groot MJ, Price D, Nettleton DO, Wallace NK, Troutman MD, Williams C, Boyd JG. Fluorescently labeled analogues of dofetilide as high-affinity fluorescence polarization ligands for the human ether-a-go-go-related gene (hERG) channel. Journal of Medicinal Chemistry. 50: 2931-41. PMID 17536794 DOI: 10.1021/jm0700565  1
2006 Knight B, Troutman M, Thakker DR. Deconvoluting the effects of P-glycoprotein on intestinal CYP3A: a major challenge. Current Opinion in Pharmacology. 6: 528-32. PMID 16899406 DOI: 10.1016/J.Coph.2006.04.009  1
2005 Doran A, Obach RS, Smith BJ, Hosea NA, Becker S, Callegari E, Chen C, Chen X, Choo E, Cianfrogna J, Cox LM, Gibbs JP, Gibbs MA, Hatch H, Hop CE, ... ... Troutman M, et al. The impact of P-glycoprotein on the disposition of drugs targeted for indications of the central nervous system: evaluation using the MDR1A/1B knockout mouse model. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 33: 165-74. PMID 15502009 DOI: 10.1124/Dmd.104.001230  1
2003 Troutman MD, Thakker DR. Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium. Pharmaceutical Research. 20: 1210-24. PMID 12948019 DOI: 10.1023/A:1025001131513  1
2003 Troutman MD, Thakker DR. Efflux ratio cannot assess P-glycoprotein-mediated attenuation of absorptive transport: asymmetric effect of P-glycoprotein on absorptive and secretory transport across Caco-2 cell monolayers. Pharmaceutical Research. 20: 1200-9. PMID 12948018 DOI: 10.1023/A:1025049014674  1
2003 Troutman MD, Thakker DR. Rhodamine 123 requires carrier-mediated influx for its activity as a P-glycoprotein substrate in Caco-2 cells. Pharmaceutical Research. 20: 1192-9. PMID 12948017 DOI: 10.1023/A:1025096930604  1
2002 Ward PD, Klein RR, Troutman MD, Desai S, Thakker DR. Phospholipase C-gamma modulates epithelial tight junction permeability through hyperphosphorylation of tight junction proteins. The Journal of Biological Chemistry. 277: 35760-5. PMID 12101180 DOI: 10.1074/Jbc.M203134200  1
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