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Chester L. Costales, Ph.D. - Publications

Affiliations: 
2013 Pharmaceutical Sciences University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Pharmacy
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14/26 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Orozco CC, Neuvonen M, Bi YA, Cerny MA, Mathialagan S, Tylaska L, Rago B, Costales C, King-Ahmad A, Niemi M, Rodrigues AD. Characterization of Bile Acid Sulfate Conjugates as Substrates of Human Organic Anion Transporting Polypeptides. Molecular Pharmaceutics. 20: 3020-3032. PMID 37134201 DOI: 10.1021/acs.molpharmaceut.3c00040  0.334
2022 Zhu Y, Binder J, Yurgelonis I, Rai DK, Lazarro S, Costales C, Kobylarz K, McMonagle P, Steppan CM, Aschenbrenner L, Anderson AS, Cardin RD. Generation of a VeroE6 Pgp gene knock out cell line and its use in SARS-CoV-2 antiviral study. Antiviral Research. 208: 105429. PMID 36208677 DOI: 10.1016/j.antiviral.2022.105429  0.317
2021 Costales C, Lin J, Kimoto E, Yamazaki S, Gosset JR, Rodrigues AD, Lazzaro S, West MA, West M, Varma MVS. Quantitative prediction of breast cancer resistant protein (BCRP) mediated drug-drug interactions using physiologically-based pharmacokinetic modeling. Cpt: Pharmacometrics & Systems Pharmacology. PMID 34164937 DOI: 10.1002/psp4.12672  0.304
2020 Luo L, Ramanathan R, Horlbogen L, Mathialagan S, Costales C, Vourvahis M, Holliman CL, Rodrigues AD. A Multiplexed HILIC-MS/HRMS Assay for the Assessment of Transporter Inhibition Biomarkers in Phase I Clinical Trials: Isobutyryl-Carnitine as an Organic Cation Transporter (OCT1) Biomarker. Analytical Chemistry. PMID 32551505 DOI: 10.1021/acs.analchem.0c01144  0.315
2020 Mathialagan S, Bi YA, Costales C, Kalgutkar AS, Rodrigues AD, Varma MVS. Nicotinic acid transport into human liver involves organic anion transporter 2 (SLC22A7). Biochemical Pharmacology. 174: 113829. PMID 32001236 DOI: 10.1016/j.bcp.2020.113829  0.46
2019 Bi YA, Costales C, Mathialagan S, West M, Eatemadpour S, Lazzaro S, Tylaska L, Scialis R, Zhang H, Umland J, Kimoto E, Tess DA, Feng B, Tremaine L, Varma MVS, et al. Quantitative contribution of six major transporters to the hepatic uptake of drugs: 'SLC-phenotyping' using primary human hepatocytes. The Journal of Pharmacology and Experimental Therapeutics. PMID 30975793 DOI: 10.1124/jpet.119.257600  0.368
2018 Kosa RE, Lazzaro S, Bi YA, Tierney B, Gates D, Modi S, Costales C, Rodrigues AD, Tremaine LM, Varma MV. Simultaneous Assessment of Transporter-Mediated Drug-Drug Interactions Using a Probe Drug Cocktail in Cynomolgus Monkey. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 29880631 DOI: 10.1124/dmd.118.081794  0.427
2018 Bi YA, Mathialagan S, Tylaska L, Fu M, Keefer J, Vildhede A, Costales C, Rodrigues AD, Varma M. Organic Anion Transporter 2 mediates hepatic uptake of tolbutamide, a Cytochrome P450 2C9 probe drug. The Journal of Pharmacology and Experimental Therapeutics. PMID 29326367 DOI: 10.1124/jpet.117.245951  0.465
2017 Mathialagan S, Costales C, Tylaska L, Kimoto E, Vildhede A, Johnson J, Johnson N, Sarashina T, Hashizume K, Isringhausen CD, Vermeer LMM, Wolff AR, Rodrigues AD. In Vitro Studies with Two Human Organic Anion Transporters: OAT2 and OAT7. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 1-48. PMID 28945155 DOI: 10.1080/00498254.2017.1384595  0.4
2017 Bi YA, Scialis R, Lazzaro S, Mathialagan S, Kimoto E, Keefer J, Zhang H, Vildhede AM, Costales C, Rodrigues AD, Tremaine LM, Varma MV. Reliable Rate Measurements for Active and Passive Hepatic Uptake Using Plated Human Hepatocytes. The Aaps Journal. PMID 28188574 DOI: 10.1208/s12248-017-0051-2  0.453
2015 Han TK, Proctor WR, Costales CL, Cai H, Everett RS, Thakker DR. Four cation-selective transporters contribute to apical uptake and accumulation of metformin in Caco-2 cell monolayers. The Journal of Pharmacology and Experimental Therapeutics. 352: 519-28. PMID 25563903 DOI: 10.1124/Jpet.114.220350  0.562
2014 Feng B, Varma MV, Costales C, Zhang H, Tremaine L. In vitro and in vivo approaches to characterize transporter-mediated disposition in drug discovery. Expert Opinion On Drug Discovery. 9: 873-90. PMID 24857286 DOI: 10.1517/17460441.2014.922540  0.344
2013 Han TK, Everett RS, Proctor WR, Ng CM, Costales CL, Brouwer KL, Thakker DR. Organic cation transporter 1 (OCT1/mOct1) is localized in the apical membrane of Caco-2 cell monolayers and enterocytes. Molecular Pharmacology. 84: 182-9. PMID 23680637 DOI: 10.1124/Mol.112.084517  0.498
2011 Klein RR, Bourdon DM, Costales CL, Wagner CD, White WL, Williams JD, Hicks SN, Sondek J, Thakker DR. Direct activation of human phospholipase C by its well known inhibitor u73122. The Journal of Biological Chemistry. 286: 12407-16. PMID 21266572 DOI: 10.1074/Jbc.M110.191783  0.467
Low-probability matches (unlikely to be authored by this person)
2021 Kimoto E, Costales C, West MA, Bi YA, Vourvahis M, David Rodrigues A, Varma MVS. Biomarker-Informed Model-Based Risk Assessment of Organic Anion Transporting Polypeptide 1B Mediated Drug-Drug Interactions. Clinical Pharmacology and Therapeutics. PMID 34605015 DOI: 10.1002/cpt.2434  0.299
2023 Lazzaro S, West MA, Eatemadpour S, Feng B, Varma MVS, Rodrigues AD, Temesszentandrási-Ambrus C, Kovács-Hajdu P, Nerada Z, Gáborik Z, Costales C. Translatability of in vitro Inhibition Potency to in vivo P-Glycoprotein Mediated Drug Interaction Risk. Journal of Pharmaceutical Sciences. PMID 36682487 DOI: 10.1016/j.xphs.2023.01.014  0.265
2019 Yamazaki S, Costales C, Lazzaro S, Eatemadpour S, Kimoto E, Varma MV. PBPK Modeling Approach to Predict Rifampin-Mediated Intestinal P-glycoprotein Induction. Cpt: Pharmacometrics & Systems Pharmacology. PMID 31420942 DOI: 10.1002/psp4.12458  0.25
2022 Lin J, Kimoto E, Yamazaki S, Vourvahis M, Bergman A, Rodrigues AD, Costales C, Li R, Varma MVS. Effect of hepatic impairment on OATP1B activity: Quantitative pharmacokinetic analysis of endogenous biomarker and substrate drugs. Clinical Pharmacology and Therapeutics. PMID 36524426 DOI: 10.1002/cpt.2829  0.237
2016 Darwich AS, Margolskee A, Pepin X, Aarons L, Galetin A, Rostami-Hodjegan A, Carlert S, Hammarberg M, Hilgendorf C, Johansson P, Karlsson E, Murphy D, Tannergren C, Thörn H, Yasin M, ... ... Costales C, et al. IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. PMID 27693299 DOI: 10.1016/j.ejps.2016.09.037  0.23
2019 Aleo MD, Shah F, Allen S, Barton HA, Costales C, Lazzaro S, Leung L, Nilson A, Obach RS, Rodrigues AD, Will Y. MOVING BEYOND BINARY PREDICTIONS OF HUMAN DRUG-INDUCED LIVER INJURY (DILI) TOWARDS CONTRASTING RELATIVE RISK POTENTIAL. Chemical Research in Toxicology. PMID 31532188 DOI: 10.1021/Acs.Chemrestox.9B00262  0.216
2018 Yamazaki S, Loi CM, Kimoto E, Costales C, Varma MV. Application of Physiologically Based Pharmacokinetic Modeling in Understanding Bosutinib Drug-Drug Interactions: Importance of Intestinal P-Glycoprotein. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 29739809 DOI: 10.1124/dmd.118.080424  0.212
2017 Bi YA, Scialis RJ, Lazzaro S, Mathialagan S, Kimoto E, Keefer J, Zhang H, Vildhede AM, Costales C, Rodrigues AD, Tremaine LM, Varma MV. Erratum to: Reliable Rate Measurements for Active and Passive Hepatic Uptake Using Plated Human Hepatocytes. The Aaps Journal. PMID 28233243 DOI: 10.1208/s12248-017-0061-0  0.202
2007 Diaz D, Scott A, Carmichael P, Shi W, Costales C. Evaluation of an automated in vitro micronucleus assay in CHO-K1 cells. Mutation Research. 630: 1-13. PMID 17446119 DOI: 10.1016/J.Mrgentox.2007.02.006  0.176
2016 Margolskee A, Darwich AS, Pepin X, Aarons L, Galetin A, Rostami-Hodjegan A, Carlert S, Hammarberg M, Hilgendorf C, Johansson P, Karlsson E, Murphy D, Tannergren C, Thörn H, Yasin M, ... ... Costales C, et al. IMI - Oral Biopharmaceutics Tools project - Evaluation of Bottom-up PBPK Prediction Success Part 2: An Introduction to the Simulation Exercise and Overview of Results. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. PMID 27816631 DOI: 10.1016/j.ejps.2016.10.036  0.151
2020 Neuvonen M, Hirvensalo P, Tornio A, Rago B, West M, Lazzaro S, Mathialagan S, Varma M, Cerny MA, Costales C, Ramanathan R, Rodrigues AD, Niemi M. Identification of Glycochenodeoxycholate 3-O-Glucuronide and Glycodeoxycholate 3-O-Glucuronide as Highly Sensitive and Specific OATP1B1 Biomarkers. Clinical Pharmacology and Therapeutics. PMID 32961594 DOI: 10.1002/cpt.2053  0.126
2006 Mao B, Gozalbes R, Barbosa F, Migeon J, Merrick S, Kamm K, Wong E, Costales C, Shi W, Wu C, Froloff N. QSAR modeling of in vitro inhibition of cytochrome P450 3A4. Journal of Chemical Information and Modeling. 46: 2125-34. PMID 16995743 DOI: 10.1021/ci0600915  0.065
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