Rabindranauth-Romel Somwar, Ph.D. - Publications

2002 University of Toronto, Toronto, ON, Canada 
Cell Biology, Molecular Biology

40 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Shukla NN, Somwar R, Smith RS, Ambati SR, Munoz S, Merchant MS, D'Arcy P, Wang X, Kobos R, Antczak C, Binder B, Shum D, Radu C, Yang G, Taylor BS, et al. Proteasome addiction defined in Ewing's sarcoma is effectively targeted by a novel class of 19S proteasome inhibitors. Cancer Research. PMID 27256563 DOI: 10.1158/0008-5472.CAN-16-1040  0.76
2016 Drilon A, Bergagnini I, Delasos L, Sabari J, Woo K, Plodkowski A, Wang L, Hellmann M, Joubert P, Sima C, Smith R, Somwar R, Rekhtman N, Ladanyi M, Riely GJ, et al. Clinical Outcomes with Pemetrexed-Based Systemic Therapies in RET-rearranged Lung Cancers. Annals of Oncology : Official Journal of the European Society For Medical Oncology / Esmo. PMID 27056998 DOI: 10.1093/annonc/mdw163  0.76
2015 Drilon A, Somwar R, Wagner JP, Vellore NA, Eide CA, Zabriskie MS, Arcila ME, Hechtman JF, Wang L, Smith RS, Kris MG, Riely GJ, Druker BJ, O'Hare T, Ladanyi M, et al. A novel crizotinib-resistant solvent-front mutation responsive to cabozantinib therapy in a patient with ROS1-rearranged lung cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 26673800 DOI: 10.1158/1078-0432.CCR-15-2013  0.76
2013 Zhu J, Larman HB, Gao G, Somwar R, Zhang Z, Laserson U, Ciccia A, Pavlova N, Church G, Zhang W, Kesari S, Elledge SJ. Protein interaction discovery using parallel analysis of translated ORFs (PLATO). Nature Biotechnology. 31: 331-4. PMID 23503679 DOI: 10.1038/nbt.2539  0.76
2012 Dunphy MP, Zanzonico P, Veach D, Somwar R, Pillarsetty N, Lewis J, Larson S. Dosimetry of 18F-labeled tyrosine kinase inhibitor SKI-249380, a dasatinib-tracer for PET imaging. Molecular Imaging and Biology : Mib : the Official Publication of the Academy of Molecular Imaging. 14: 25-31. PMID 21161687 DOI: 10.1007/s11307-010-0462-2  0.76
2011 Somwar R, Erdjument-Bromage H, Larsson E, Shum D, Lockwood WW, Yang G, Sander C, Ouerfelli O, Tempst PJ, Djaballah H, Varmus HE. Superoxide dismutase 1 (SOD1) is a target for a small molecule identified in a screen for inhibitors of the growth of lung adenocarcinoma cell lines. Proceedings of the National Academy of Sciences of the United States of America. 108: 16375-80. PMID 21930909 DOI: 10.1073/pnas.1113554108  0.76
2011 Chmielecki J, Foo J, Oxnard GR, Hutchinson K, Ohashi K, Somwar R, Wang L, Amato KR, Arcila M, Sos ML, Socci ND, Viale A, de Stanchina E, Ginsberg MS, Thomas RK, et al. Optimization of dosing for EGFR-mutant non-small cell lung cancer with evolutionary cancer modeling. Science Translational Medicine. 3: 90ra59. PMID 21734175 DOI: 10.1126/scitranslmed.3002356  0.76
2011 Somwar R, Roberts CT, Varlamov O. Live-cell imaging demonstrates rapid cargo exchange between lipid droplets in adipocytes. Febs Letters. 585: 1946-50. PMID 21575639 DOI: 10.1016/j.febslet.2011.05.016  0.76
2010 Varlamov O, Somwar R, Cornea A, Kievit P, Grove KL, Roberts CT. Single-cell analysis of insulin-regulated fatty acid uptake in adipocytes. American Journal of Physiology. Endocrinology and Metabolism. 299: E486-96. PMID 20570821 DOI: 10.1152/ajpendo.00330.2010  0.76
2009 Somwar R, Shum D, Djaballah H, Varmus H. Identification and preliminary characterization of novel small molecules that inhibit growth of human lung adenocarcinoma cells Journal of Biomolecular Screening. 14: 1176-1184. PMID 19887599 DOI: 10.1177/1087057109350919  0.76
2009 Chitale D, Gong Y, Taylor BS, Broderick S, Brennan C, Somwar R, Golas B, Wang L, Motoi N, Szoke J, Reinersman JM, Major J, Sander C, Seshan VE, Zakowski MF, et al. An integrated genomic analysis of lung cancer reveals loss of DUSP4 in EGFR-mutant tumors. Oncogene. 28: 2773-83. PMID 19525976 DOI: 10.1038/onc.2009.135  0.76
2007 Gong Y, Somwar R, Politi K, Balak M, Chmielecki J, Jiang X, Pao W. Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas. Plos Medicine. 4: e294. PMID 17927446 DOI: 10.1371/journal.pmed.0040294  0.76
2006 Balak MN, Gong Y, Riely GJ, Somwar R, Li AR, Zakowski MF, Chiang A, Yang G, Ouerfelli O, Kris MG, Ladanyi M, Miller VA, Pao W. Novel D761Y and common secondary T790M mutations in epidermal growth factor receptor-mutant lung adenocarcinomas with acquired resistance to kinase inhibitors. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 12: 6494-501. PMID 17085664 DOI: 10.1158/1078-0432.CCR-06-1570  0.76
2005 Pao W, Miller VA, Politi KA, Riely GJ, Somwar R, Zakowski MF, Kris MG, Varmus H. Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain Plos Medicine. 2: 0225-0235. PMID 15737014 DOI: 10.1371/journal.pmed.0020073  0.76
2005 Ceddia RB, Somwar R, Maida A, Fang X, Bikopoulos G, Sweeney G. Globular adiponectin increases GLUT4 translocation and glucose uptake but reduces glycogen synthesis in rat skeletal muscle cells. Diabetologia. 48: 132-9. PMID 15619075 DOI: 10.1007/s00125-004-1609-y  0.76
2005 Somwar R, Fang X, Sweeney G. Models of type 2 diabetes Drug Discovery Today: Disease Models. 2: 183-189. DOI: 10.1016/j.ddmod.2005.08.011  0.76
2005 Politi KA, Riely GJ, Somwar R, Zakowski MF, Kris MG. Second mutations in EGFR provide clues to acquired resistance to Iressa and Tarceva Cancer Biology and Therapy. 4.  0.76
2004 Sweeney G, Garg RR, Ceddia RB, Li D, Ishiki M, Somwar R, Foster LJ, Neilsen PO, Prestwich GD, Rudich A, Klip A. Intracellular delivery of phosphatidylinositol (3,4,5)-trisphosphate causes incorporation of glucose transporter 4 into the plasma membrane of muscle and fat cells without increasing glucose uptake. The Journal of Biological Chemistry. 279: 32233-42. PMID 15166230 DOI: 10.1074/jbc.M402897200  0.76
2003 Niu W, Huang C, Nawaz Z, Levy M, Somwar R, Li D, Bilan PJ, Klip A. Maturation of the regulation of GLUT4 activity by p38 MAPK during L6 cell myogenesis. The Journal of Biological Chemistry. 278: 17953-62. PMID 12637564 DOI: 10.1074/jbc.M211136200  0.76
2002 Furtado LM, Somwar R, Sweeney G, Niu W, Klip A. Activation of the glucose transporter GLUT4 by insulin. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 80: 569-78. PMID 12440698 DOI: 10.1139/o02-156  0.76
2002 Somwar R, Koterski S, Sweeney G, Sciotti R, Djuric S, Berg C, Trevillyan J, Scherer PE, Rondinone CM, Klip A. A dominant-negative p38 MAPK mutant and novel selective inhibitors of p38 MAPK reduce insulin-stimulated glucose uptake in 3T3-L1 adipocytes without affecting GLUT4 translocation. The Journal of Biological Chemistry. 277: 50386-95. PMID 12393894 DOI: 10.1074/jbc.M205277200  0.76
2002 Huang C, Somwar R, Patel N, Niu W, Török D, Klip A. Sustained exposure of L6 myotubes to high glucose and insulin decreases insulin-stimulated GLUT4 translocation but upregulates GLUT4 activity. Diabetes. 51: 2090-8. PMID 12086937  0.76
2001 Somwar R, Kim DY, Sweeney G, Huang C, Niu W, Lador C, Ramlal T, Klip A. GLUT4 translocation precedes the stimulation of glucose uptake by insulin in muscle cells: potential activation of GLUT4 via p38 mitogen-activated protein kinase. The Biochemical Journal. 359: 639-49. PMID 11672439 DOI: 10.1042/0264-6021:3590639  0.76
2001 Sweeney G, Keen J, Somwar R, Konrad D, Garg R, Klip A. High leptin levels acutely inhibit insulin-stimulated glucose uptake without affecting glucose transporter 4 translocation in l6 rat skeletal muscle cells. Endocrinology. 142: 4806-12. PMID 11606447 DOI: 10.1210/endo.142.11.8496  0.76
2001 Somwar R, Niu W, Kim DY, Sweeney G, Randhawa VK, Huang C, Ramlal T, Klip A. Differential effects of phosphatidylinositol 3-kinase inhibition on intracellular signals regulating GLUT4 translocation and glucose transport. The Journal of Biological Chemistry. 276: 46079-87. PMID 11598141 DOI: 10.1074/jbc.M109093200  0.76
2001 Konrad D, Somwar R, Sweeney G, Yaworsky K, Hayashi M, Ramlal T, Klip A. The antihyperglycemic drug alpha-lipoic acid stimulates glucose uptake via both GLUT4 translocation and GLUT4 activation: potential role of p38 mitogen-activated protein kinase in GLUT4 activation. Diabetes. 50: 1464-71. PMID 11375349  0.76
2000 Somwar R, Perreault M, Kapur S, Taha C, Sweeney G, Ramlal T, Kim DY, Keen J, Côte CH, Klip A, Marette A. Activation of p38 mitogen-activated protein kinase alpha and beta by insulin and contraction in rat skeletal muscle: potential role in the stimulation of glucose transport. Diabetes. 49: 1794-800. PMID 11078445 DOI: 10.2337/diabetes.49.11.1794  0.76
2000 Yaworsky K, Somwar R, Ramlal T, Tritschler HJ, Klip A. Engagement of the insulin-sensitive pathway in the stimulation of glucose transport by alpha-lipoic acid in 3T3-L1 adipocytes. Diabetologia. 43: 294-303. PMID 10768090 DOI: 10.1007/s001250050047  0.76
1999 Yusta B, Somwar R, Wang F, Munroe D, Grinstein S, Klip A, Drucker DJ. Identification of glucagon-like peptide-2 (GLP-2)-activated signaling pathways in baby hamster kidney fibroblasts expressing the rat GLP-2 receptor. The Journal of Biological Chemistry. 274: 30459-67. PMID 10521425 DOI: 10.1074/jbc.274.43.30459  0.76
1999 Wang Q, Somwar R, Bilan PJ, Liu Z, Jin J, Woodgett JR, Klip A. Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts. Molecular and Cellular Biology. 19: 4008-18. PMID 10330141 DOI: 10.1128/MCB.19.6.4008  0.76
1999 Sweeney G, Somwar R, Ramlal T, Volchuk A, Ueyama A, Klip A. An inhibitor of p38 mitogen-activated protein kinase prevents insulin-stimulated glucose transport but not glucose transporter translocation in 3T3-L1 adipocytes and L6 myotubes. The Journal of Biological Chemistry. 274: 10071-8. PMID 10187787 DOI: 10.1074/jbc.274.15.10071  0.76
1998 Khayat ZA, Tsakiridis T, Ueyama A, Somwar R, Ebina Y, Klip A. Rapid stimulation of glucose transport by mitochondrial uncoupling depends in part on cytosolic Ca2+ and cPKC. The American Journal of Physiology. 275: C1487-97. PMID 9843710  0.76
1998 Sweeney G, Somwar R, Ramlal T, Martin-Vasallo P, Klip A. Insulin stimulation of K+ uptake in 3T3-L1 fibroblasts involves phosphatidylinositol 3-kinase and protein kinase C-zeta. Diabetologia. 41: 1199-204. PMID 9794108 DOI: 10.1007/s001250051052  0.76
1998 Tsakiridis T, Bergman A, Somwar R, Taha C, Aktories K, Cruz TF, Klip A, Downey GP. Actin filaments facilitate insulin activation of the src and collagen homologous/mitogen-activated protein kinase pathway leading to DNA synthesis and c-fos expression. The Journal of Biological Chemistry. 273: 28322-31. PMID 9774456 DOI: 10.1074/jbc.273.43.28322  0.76
1998 Somwar R, Sumitani S, Taha C, Sweeney G, Klip A. Temporal activation of p70 S6 kinase and Akt1 by insulin: PI 3-kinase-dependent and -independent mechanisms. The American Journal of Physiology. 275: E618-25. PMID 9755080  0.76
1998 Ewart HS, Somwar R, Klip A. Dexamethasone stimulates the expression of GLUT1 and GLUT4 proteins via different signalling pathways in L6 skeletal muscle cells. Febs Letters. 425: 179-83. PMID 9541032  0.76
1998 Somwar R, Sweeney G, Ramlal T, Klip A. Stimulation of glucose and amino acid transport and activation of the insulin signaling pathways by insulin lispro in L6 skeletal muscle cells. Clinical Therapeutics. 20: 125-40. PMID 9522110 DOI: 10.1016/S0149-2918(98)80040-4  0.76
1998 Ewart HS, Somwar R, Klip A. Dexamethasone stimulates the expression of GLUT1 and GLUT4 proteins via different signalling pathways in L6 skeletal muscle cells. Febs Letters. 421: 120-4. PMID 9468291 DOI: 10.1016/S0014-5793(97)01549-4  0.76
1997 Sumitani S, Ramlal T, Somwar R, Keller SR, Klip A. Insulin regulation and selective segregation with glucose transporter-4 of the membrane aminopeptidase vp165 in rat skeletal muscle cells. Endocrinology. 138: 1029-34. PMID 9048605 DOI: 10.1210/endo.138.3.5010  0.76
1996 Ramlal T, Ewart HS, Somwar R, Deems RO, Valentin MA, Young DA, Klip A. Muscle subcellular localization and recruitment by insulin of glucose transporters and Na+-K+-ATPase subunits in transgenic mice overexpressing the GLUT4 glucose transporter. Diabetes. 45: 1516-23. PMID 8866555 DOI: 10.2337/diab.45.11.1516  0.76
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