| Year |
Citation |
Score |
| 2019 |
Lickteig B, Wimalasena VK, Wimalasena K. MPP+ Scaffold Containing Lipophilic Compounds are Potent Complex I Inhibitors and Selective Dopaminergic Toxins. Acs Chemical Neuroscience. PMID 30929447 DOI: 10.1021/Acschemneuro.9B00184 |
0.337 |
|
| 2016 |
Kadigamuwa CC, Mapa MS, Wimalasena K. Lipophilic Cationic Cyanines Are Potent Complex I Inhibitors and Specific in Vitro Dopaminergic Toxins with Mechanistic Similarities to Both Rotenone and MPP(.) Chemical Research in Toxicology. PMID 27510327 DOI: 10.1021/Acs.Chemrestox.6B00138 |
0.31 |
|
| 2008 |
Wimalasena DS, Perera RP, Heyen BJ, Balasooriya IS, Wimalasena K. Vesicular monoamine transporter substrate/inhibitor activity of MPTP/MPP+ derivatives: a structure-activity study. Journal of Medicinal Chemistry. 51: 760-8. PMID 18220329 DOI: 10.1021/Jm070875P |
0.347 |
|
| 2008 |
Bhakta MN, Olabisi A, Wimalasena K, Wilks A. Catalytic turnover dependent modification of the Pseudomonas aeruginosa heme oxygenase (pa-HO) by 5,6-O-isopropyledine-2-O-allyl-ascorbic acid. Journal of Inorganic Biochemistry. 102: 251-9. PMID 17923157 DOI: 10.1016/J.Jinorgbio.2007.08.007 |
0.734 |
|
| 2007 |
Samms WC, Perera RP, Wimalasena DS, Wimalasena K. Perturbation of dopamine metabolism by 3-amino-2-(4'-halophenyl)propenes leads to increased oxidative stress and apoptotic SH-SY5Y cell death. Molecular Pharmacology. 72: 744-52. PMID 17576792 DOI: 10.1124/Mol.107.035873 |
0.346 |
|
| 2007 |
Wimalasena DS, Wiese TJ, Wimalasena K. Copper ions disrupt dopamine metabolism via inhibition of V-H+-ATPase: a possible contributing factor to neurotoxicity. Journal of Neurochemistry. 101: 313-26. PMID 17217412 DOI: 10.1111/J.1471-4159.2006.04362.X |
0.307 |
|
| 2005 |
Olabisi AO, Mahindaratne MP, Wimalasena K. A convenient entry to C2- and C3-substituted gulono-gamma-lactone derivatives from L-ascorbic acid. The Journal of Organic Chemistry. 70: 6782-9. PMID 16095297 DOI: 10.1021/Jo0508550 |
0.755 |
|
| 2005 |
Bhakta M, Hollenberg PF, Wimalasena K. Evidence for a hydrogen abstraction mechanism in P450-catalyzed N-dealkylations. Chemical Communications (Cambridge, England). 265-7. PMID 15724207 DOI: 10.1039/B412221F |
0.743 |
|
| 2005 |
Bhakta MN, Hollenberg PF, Wimalasena K. P(450)/NADPH/O(2)- and P(450)/PhIO-catalyzed N-dealkylations are mechanistically distinct. Journal of the American Chemical Society. 127: 1376-7. PMID 15686361 DOI: 10.1021/Ja0436143 |
0.77 |
|
| 2005 |
Bhakta MN, Wimalasena K. A Mechanistic Comparison between Cytochrome P450- and Chloroperoxidase-CatalyzedN-Dealkylation ofN,N-Dialkyl Anilines European Journal of Organic Chemistry. 2005: 4801-4805. DOI: 10.1002/Ejoc.200500333 |
0.766 |
|
| 2004 |
Olabisi AO, Wimalasena K. Rational approach to selective and direct 2-O-alkylation of 5,6-O-isopropylidine-L-ascorbic acid. The Journal of Organic Chemistry. 69: 7026-32. PMID 15471448 DOI: 10.1002/CHIN.200507213 |
0.769 |
|
| 2004 |
Wimalasena DS, Wimalasena K. Kinetic evidence for channeling of dopamine between monoamine transporter and membranous dopamine-beta-monooxygenase in chromaffin granule ghosts. The Journal of Biological Chemistry. 279: 15298-304. PMID 14732710 DOI: 10.1074/Jbc.M313325200 |
0.318 |
|
| 2003 |
Perera RP, Wimalasena DS, Wimalasena K. Characterization of a series of 3-amino-2-phenylpropene derivatives as novel bovine chromaffin vesicular monoamine transporter inhibitors. Journal of Medicinal Chemistry. 46: 2599-605. PMID 12801224 DOI: 10.1021/Jm030004P |
0.336 |
|
| 2003 |
Wanduragala S, Wimalasena DS, Haines DC, Kahol PK, Wimalasena K. pH-induced alteration and oxidative destruction of heme in purified chromaffin granule cytochrome b(561): implications for the oxidative stress in catecholaminergic neurons. Biochemistry. 42: 3617-26. PMID 12653566 DOI: 10.1021/Bi0206661 |
0.704 |
|
| 2002 |
Dharmasena SP, Wimalasena DS, Wimalasena K. A slow-tight binding inhibitor of dopamine beta-monooxygenase: a transition state analogue for the product release step. Biochemistry. 41: 12414-20. PMID 12369831 DOI: 10.1021/Bi0262606 |
0.34 |
|
| 2002 |
Wimalasena DS, Jayatillake SP, Haines DC, Wimalasena K. Plausible molecular mechanism for activation by fumarate and electron transfer of the dopamine beta-mono-oxygenase reaction. The Biochemical Journal. 367: 77-85. PMID 12038965 DOI: 10.1042/Bj20020216 |
0.738 |
|
| 2002 |
Bhakta MN, Wimalasena K. Microsomal P450-catalyzed N-dealkylation of N,N-dialkylanilines: evidence for a C(alpha)-H abstraction mechanism. Journal of the American Chemical Society. 124: 1844-5. PMID 11866584 DOI: 10.1021/Ja011041D |
0.741 |
|
| 2001 |
Wimalasena K, Wickman H, Mahindaratne M. Autocatalytic Radical Ring Opening ofN-Cyclopropyl-N-phenylamines Under Aerobic Conditions − Exclusive Formation of the Unknown Oxygen Adducts,N-(1,2-Dioxolan-3-yl)-N-phenylamines European Journal of Organic Chemistry. 2001: 3811-3817. DOI: 10.1002/1099-0690(200110)2001:20<3811::Aid-Ejoc3811>3.0.Co;2-6 |
0.367 |
|
| 1999 |
Wimalasena K, Alliston KR. Mode of substrate interaction and energetics of carbon-oxygen bond formation of the dopamine beta-monooxygenase reaction. Biochemistry. 38: 14916-26. PMID 10555974 DOI: 10.1021/Bi990703X |
0.378 |
|
| 1998 |
Mahindaratne MPD, Wimalasena K. Detailed Characterization ofp-Toluenesulfonic Acid Monohydrate as a Convenient, Recoverable, Safe, and Selective Catalyst for Alkylation of the Aromatic Nucleus The Journal of Organic Chemistry. 63: 2858-2866. DOI: 10.1021/Jo971832R |
0.35 |
|
| 1997 |
Wimalasena K, Wimalasena DS, Dharmasena S, Haines DC, Alliston KR. Chiral multisubstrate inhibitors of dopamine beta-monooxygenase: evidence for dual modes of interaction. Biochemistry. 36: 7144-53. PMID 9188714 DOI: 10.1021/bi963048r |
0.707 |
|
| 1996 |
Wimalasena K, Dharmasena S, Wimalasena DS, Hughbanks-Wheaton DK. Reduction of dopamine beta-monooxygenase. A unified model for apparent negative cooperativity and fumarate activation. The Journal of Biological Chemistry. 271: 26032-43. PMID 8824243 DOI: 10.1074/Jbc.271.42.26032 |
0.418 |
|
| 1996 |
Wimalasena K, Haines DC. A general progress curve method for the kinetic analysis of suicide enzyme inhibitors. Analytical Biochemistry. 234: 175-82. PMID 8714595 DOI: 10.1006/Abio.1996.0069 |
0.695 |
|
| 1995 |
Wimalasena K, Wimalasena DS. The reduction of membrane-bound dopamine beta-monooxygenase in resealed chromaffin granule ghosts. Is intragranular ascorbic acid a mediator for extragranular reducing equivalents? The Journal of Biological Chemistry. 270: 27516-24. PMID 7499210 DOI: 10.1074/Jbc.270.46.27516 |
0.313 |
|
| 1995 |
Wimalasena K, May SW. Ascorbic acid mediated N-dealkylation and N-deoxygenation of N,N'-dimethylaniline N-oxide Journal of the American Chemical Society. 117: 2381-2386. DOI: 10.1021/Ja00114A001 |
0.604 |
|
| 1995 |
Wimalasena K, Alliston KR. 1-(2-Aminoethyl)-1,4-cyclohexadiene: A Probe To Examine the Chemistry and Energetics Of The C-H Bond Cleavage in Dopamine .beta.-Monooxygenase Catalysis Journal of the American Chemical Society. 117: 1220-1224. DOI: 10.1021/Ja00109A005 |
0.314 |
|
| 1994 |
Wimalasena K, Dharmasena S, Wimalasena DS. Ascorbate based novel high affinity alternate reductants and competitive inhibitors of dopamine beta-monooxygenase. Biochemical and Biophysical Research Communications. 200: 113-9. PMID 8166679 DOI: 10.1006/Bbrc.1994.1422 |
0.404 |
|
| 1994 |
Wimalasena K, Dharmasena S. Substrate specificity of ascorbate oxidase: unexpected similarity to the reduction site of dopamine beta-monooxygenase. Biochemical and Biophysical Research Communications. 203: 1471-6. PMID 7945293 DOI: 10.1006/Bbrc.1994.2350 |
0.407 |
|
| 1994 |
Wimalasena K, Haines DC. Nucleophilic Substitution Reactions of Phenacyl Bromide Oxime: Effect of the Solvent and the Basicity of the Nucleophile The Journal of Organic Chemistry. 59: 6472-6475. DOI: 10.1021/Jo00100A062 |
0.712 |
|
| 1994 |
Wimalasena K, Mahindaratne MPD. Chemistry of L-Ascorbic Acid: Regioselective and Stereocontrolled 2-C- and 3-C-Allylation via Thermal Claisen Rearrangement The Journal of Organic Chemistry. 59: 3427-3432. DOI: 10.1021/Jo00091A036 |
0.387 |
|
| 1993 |
Wimalasena K, Dharmasena S. Continuous spectrophotometric assay for ascorbate oxidase based on a novel chromophoric substrate, 2-aminoascorbic acid. Analytical Biochemistry. 210: 58-62. PMID 8489025 DOI: 10.1006/Abio.1993.1150 |
0.417 |
|
| 1991 |
Wimalasena K, Wimalasena DS. N,N,N',N'-tetramethyl-1,4-phenylenediamine: a facile electron donor and chromophoric substrate for dopamine beta-monooxygenase. Biochemical and Biophysical Research Communications. 175: 920-7. PMID 2025264 DOI: 10.1016/0006-291X(91)91653-T |
0.427 |
|
| 1991 |
Wimalasena K, Wimalasena DS. Continuous spectrophotometric assays for dopamine beta-monooxygenase based on two novel electron donors: N,N-dimethyl-1,4-phenylenediamine and 2-aminoascorbic acid. Analytical Biochemistry. 197: 353-61. PMID 1785690 DOI: 10.1016/0003-2697(91)90404-H |
0.408 |
|
| 1989 |
Wimalasena K, Herman HH, May SW. Effects of dopamine beta-monooxygenase substrate analogs on ascorbate levels and norepinephrine synthesis in adrenal chromaffin granule ghosts. The Journal of Biological Chemistry. 264: 124-30. PMID 2909510 |
0.565 |
|
| 1989 |
Wimalasena K, May SW. Dopamine .beta.-monooxygenase-catalyzed aromatization of 1-(2-aminoethyl)-1,4-cyclohexadiene: redirection of specificity and evidence for a hydrogen-atom-transfer mechanism Journal of the American Chemical Society. 111: 2729-2731. DOI: 10.1021/Ja00189A065 |
0.584 |
|
| 1989 |
WIMALASENA K, MAY SW. ChemInform Abstract: Dopamine β-Monooxygenase Catalyzed Aromatization of 1-(2-Aminoethyl)-1,4-cyclohexadiene: Redirection of Specificity and Evidence for a Hydrogen Atom Transfer Mechanism. Cheminform. 20. DOI: 10.1002/chin.198929076 |
0.531 |
|
| 1988 |
May SW, Wimalasena K, Herman HH, Fowler LC, Ciccarello MC, Pollock SH. Novel antihypertensives targeted at dopamine beta-monooxygenase: turnover-dependent cofactor depletion by phenyl aminoethyl selenide. Journal of Medicinal Chemistry. 31: 1066-8. PMID 3373481 DOI: 10.1021/Jm00401A003 |
0.557 |
|
| 1988 |
Herman HH, Wimalasena K, Fowler LC, Beard CA, May SW. Demonstration of the ascorbate dependence of membrane-bound dopamine beta-monooxygenase in adrenal chromaffin granule ghosts. The Journal of Biological Chemistry. 263: 666-72. PMID 3335518 |
0.536 |
|
| 1987 |
Wimalasena K, May SW. Mechanistic studies on dopamine .beta.-monooxygenase catalysis: N-dealkylation and mechanism-based inhibition by benzylic-nitrogen-containing compounds. Evidence for a single-electron-transfer mechanism Journal of the American Chemical Society. 109: 4036-4046. DOI: 10.1021/Ja00247A033 |
0.613 |
|
| 1987 |
WIMALASENA K, MAY SW. ChemInform Abstract: Mechanistic Studies on Dopamine β-Monooxygenase Catalysis: N-Dealkylation and Mechanism-Based Inhibition by Benzylic-Nitrogen-Containing Compounds. Evidence for a Single-Electron-Transfer Mechanism. Cheminform. 18. DOI: 10.1002/chin.198743348 |
0.565 |
|
| 1985 |
Padgette SR, Wimalasena K, Herman HH, Sirimanne SR, May SW. Olefin oxygenation and N-dealkylation by dopamine beta-monooxygenase: catalysis and mechanism-based inhibition. Biochemistry. 24: 5826-39. PMID 4084493 DOI: 10.1021/Bi00342A021 |
0.665 |
|
| 1985 |
KATOPODIS AG, WIMALASENA K, LEE J, MAY SW. ChemInform Abstract: MECHANISTIC STUDIES ON NON-HEME IRON MONOOXYGENASE CATALYSIS: EPOXIDATION, ALDEHYDE FORMATION AND DEMETHYLATION BY THE Ω-HYDROXYLATION SYSTEM OF PSEUDOMONAS OLEOVORANS Chemischer Informationsdienst. 16. DOI: 10.1002/Chin.198515102 |
0.531 |
|
| 1984 |
Katopodis AG, Wimalasena K, Lee J, May SW. Mechanistic studies on non-heme iron monooxygenase catalysis: epoxidation, aldehyde formation and demethylation by the .omega.-hydroxylation system of Pseudomonas oleovorans Journal of the American Chemical Society. 106: 7928-7935. DOI: 10.1021/Ja00337A049 |
0.57 |
|
| 1984 |
May SW, Lee LG, Katopodis AG, Kuo JY, Wimalasena K, Thowsen JR. Rubredoxin from Pseudomonas oleovorans: effects of selective chemical modification and metal substitution Biochemistry. 23: 2187-2192. DOI: 10.1021/Bi00305A013 |
0.526 |
|
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