Chris Dealwis - Publications

The University of Tennessee 

29 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Ahmad MF, Alam I, Huff SE, Pink J, Flanagan SA, Shewach D, Misko TA, Oleinick NL, Harte WE, Viswanathan R, Harris ME, Dealwis CG. Potent competitive inhibition of human ribonucleotide reductase by a nonnucleoside small molecule. Proceedings of the National Academy of Sciences of the United States of America. PMID 28716944 DOI: 10.1073/pnas.1620220114  0.44
2016 Knappenberger AJ, Mohammed FA, Viswanathan R, Dealwis CG, Harris ME. Nucleoside analog triphosphates allosterically regulate human ribonucleotide reductase and identify chemical determinants that drive substrate specificity. Biochemistry. PMID 27634056 DOI: 10.1021/acs.biochem.6b00594  0.44
2016 Misko TA, Wijerathna SR, Radivoyevitch T, Berdis AJ, Ahmad MF, Harris ME, Dealwis CG. Inhibition of yeast ribonucleotide reductase by Sml1 depends on the allosteric state of the enzyme. Febs Letters. PMID 27155231 DOI: 10.1002/1873-3468.12207  0.44
2015 Ahmad MF, Huff SE, Pink J, Alam I, Zhang A, Perry K, Harris ME, Misko T, Porwal SK, Oleinick NL, Miyagi M, Viswanathan R, Dealwis CG. Identification of non-nucleoside human ribonucleotide reductase modulators. Journal of Medicinal Chemistry. PMID 26488902 DOI: 10.1021/acs.jmedchem.5b00929  0.44
2014 Wan Q, Bennett BC, Wilson MA, Kovalevsky A, Langan P, Howell EE, Dealwis C. Toward resolving the catalytic mechanism of dihydrofolate reductase using neutron and ultrahigh-resolution X-ray crystallography. Proceedings of the National Academy of Sciences of the United States of America. 111: 18225-30. PMID 25453083 DOI: 10.1073/pnas.1415856111  0.44
2014 Wan Q, Kovalevsky AY, Wilson MA, Bennett BC, Langan P, Dealwis C. Preliminary joint X-ray and neutron protein crystallographic studies of ecDHFR complexed with folate and NADP+. Acta Crystallographica. Section F, Structural Biology Communications. 70: 814-8. PMID 24915100 DOI: 10.1107/S2053230X1400942X  0.44
2013 Ahmad MF, Dealwis CG. The structural basis for the allosteric regulation of ribonucleotide reductase. Progress in Molecular Biology and Translational Science. 117: 389-410. PMID 23663976 DOI: 10.1016/B978-0-12-386931-9.00014-3  0.44
2012 Ahmad MF, Wan Q, Jha S, Motea E, Berdis A, Dealwis C. Evaluating the therapeutic potential of a non-natural nucleotide that inhibits human ribonucleotide reductase. Molecular Cancer Therapeutics. 11: 2077-86. PMID 22933704 DOI: 10.1158/1535-7163.MCT-12-0199  0.44
2012 Ahmad MF, Kaushal PS, Wan Q, Wijerathna SR, An X, Huang M, Dealwis CG. Role of arginine 293 and glutamine 288 in communication between catalytic and allosteric sites in yeast ribonucleotide reductase. Journal of Molecular Biology. 419: 315-29. PMID 22465672 DOI: 10.1016/j.jmb.2012.03.014  0.44
2011 Wijerathna SR, Ahmad MF, Xu H, Fairman JW, Zhang A, Kaushal PS, Wan Q, Kiser J, Dealwis CG. Targeting the Large Subunit of Human Ribonucleotide Reductase for Cancer Chemotherapy. Pharmaceuticals (Basel, Switzerland). 4: 1328-1354. PMID 23115527 DOI: 10.3390/ph4101328  0.52
2011 Wan Q, Ahmad MF, Fairman J, Gorzelle B, de la Fuente M, Dealwis C, Maguire ME. X-ray crystallography and isothermal titration calorimetry studies of the Salmonella zinc transporter ZntB. Structure (London, England : 1993). 19: 700-10. PMID 21565704 DOI: 10.1016/j.str.2011.02.011  0.44
2011 Miyagi M, Wan Q, Ahmad MF, Gokulrangan G, Tomechko SE, Bennett B, Dealwis C. Histidine hydrogen-deuterium exchange mass spectrometry for probing the microenvironment of histidine residues in dihydrofolate reductase. Plos One. 6: e17055. PMID 21359214 DOI: 10.1371/journal.pone.0017055  0.44
2011 Fairman JW, Wijerathna SR, Ahmad MF, Xu H, Nakano R, Jha S, Prendergast J, Welin RM, Flodin S, Roos A, Nordlund P, Li Z, Walz T, Dealwis CG. Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization. Nature Structural & Molecular Biology. 18: 316-22. PMID 21336276 DOI: 10.1038/nsmb.2007  0.52
2009 Sun D, Xu H, Wijerathna SR, Dealwis C, Lee RE. Structure-Based Design, Synthesis, and Evaluation of 2'-(2-Hydroxyethyl)-2'-deoxyadenosine and the 5'-Diphosphate Derivative as Ribonucleotide Reductase Inhibitors. Chemmedchem. 4: 1649-56. PMID 19681093 DOI: 10.1002/cmdc.200900236  0.52
2009 Bennett BC, Wan Q, Ahmad MF, Langan P, Dealwis CG. X-ray structure of the ternary MTX.NADPH complex of the anthrax dihydrofolate reductase: a pharmacophore for dual-site inhibitor design. Journal of Structural Biology. 166: 162-71. PMID 19374017  0.44
2008 Xu H, Fairman JW, Wijerathna SR, Kreischer NR, LaMacchia J, Helmbrecht E, Cooperman BS, Dealwis C. The structural basis for peptidomimetic inhibition of eukaryotic ribonucleotide reductase: a conformationally flexible pharmacophore. Journal of Medicinal Chemistry. 51: 4653-9. PMID 18610997 DOI: 10.1021/jm800350u  0.52
2008 Bennett BC, Gardberg AS, Blair MD, Dealwis CG. On the determinants of amide backbone exchange in proteins: a neutron crystallographic comparative study. Acta Crystallographica. Section D, Biological Crystallography. 764-83. PMID 18566512 DOI: 10.1107/S0907444908012845  0.44
2008 Langan P, Fisher Z, Kovalevsky A, Mustyakimov M, Sutcliffe Valone A, Unkefer C, Waltman MJ, Coates L, Adams PD, Afonine PV, Bennett B, Dealwis C, Schoenborn BP. Protein structures by spallation neutron crystallography. Journal of Synchrotron Radiation. 15: 215-8. PMID 18421142 DOI: 10.1107/S0909049508000824  0.44
2007 Gardberg AS, Dice LT, Ou S, Rich RL, Helmbrecht E, Ko J, Wetzel R, Myszka DG, Patterson PH, Dealwis C. Molecular basis for passive immunotherapy of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 104: 15659-64. PMID 17895381 DOI: 10.1073/pnas.0705888104  0.56
2007 Bennett BC, Xu H, Simmerman RF, Lee RE, Dealwis CG. Crystal structure of the anthrax drug target, Bacillus anthracis dihydrofolate reductase. Journal of Medicinal Chemistry. 50: 4374-81. PMID 17696333 DOI: 10.1021/jm070319v  0.52
2006 Bennett B, Langan P, Coates L, Mustyakimov M, Schoenborn B, Howell EE, Dealwis C. Neutron diffraction studies of Escherichia coli dihydrofolate reductase complexed with methotrexate. Proceedings of the National Academy of Sciences of the United States of America. 103: 18493-8. PMID 17130456 DOI: 10.1073/pnas.0604977103  0.44
2006 Xu H, Faber C, Uchiki T, Racca J, Dealwis C. Structures of eukaryotic ribonucleotide reductase I define gemcitabine diphosphate binding and subunit assembly. Proceedings of the National Academy of Sciences of the United States of America. 103: 4028-33. PMID 16537480 DOI: 10.1073/pnas.0600440103  0.56
2006 Xu H, Faber C, Uchiki T, Fairman JW, Racca J, Dealwis C. Structures of eukaryotic ribonucleotide reductase I provide insights into dNTP regulation. Proceedings of the National Academy of Sciences of the United States of America. 103: 4022-7. PMID 16537479 DOI: 10.1073/pnas.0600443103  0.56
2005 Bennett BC, Meilleur F, Myles DA, Howell EE, Dealwis CG. Preliminary neutron diffraction studies of Escherichia coli dihydrofolate reductase bound to the anticancer drug methotrexate. Acta Crystallographica. Section D, Biological Crystallography. 61: 574-9. PMID 15858267 DOI: 10.1107/S0907444905004804  0.44
2005 Sharp JS, Guo JT, Uchiki T, Xu Y, Dealwis C, Hettich RL. Photochemical surface mapping of C14S-Sml1p for constrained computational modeling of protein structure. Analytical Biochemistry. 340: 201-12. PMID 15840492 DOI: 10.1016/j.ab.2005.02.005  0.56
2004 Wall JS, Gupta V, Wilkerson M, Schell M, Loris R, Adams P, Solomon A, Stevens F, Dealwis C. Structural basis of light chain amyloidogenicity: comparison of the thermodynamic properties, fibrillogenic potential and tertiary structural features of four Vlambda6 proteins. Journal of Molecular Recognition : Jmr. 17: 323-31. PMID 15227639 DOI: 10.1002/jmr.681  0.56
2004 Gupta V, Peterson CB, Dice LT, Uchiki T, Racca J, Guo JT, Xu Y, Hettich R, Zhao X, Rothstein R, Dealwis CG. Sml1p is a dimer in solution: characterization of denaturation and renaturation of recombinant Sml1p. Biochemistry. 43: 8568-78. PMID 15222768 DOI: 10.1021/bi0361721  0.56
2004 Uchiki T, Dice LT, Hettich RL, Dealwis C. Identification of phosphorylation sites on the yeast ribonucleotide reductase inhibitor Sml1. The Journal of Biological Chemistry. 279: 11293-303. PMID 14684746 DOI: 10.1074/jbc.M309751200  0.56
2002 Uchiki T, Hettich R, Gupta V, Dealwis C. Characterization of monomeric and dimeric forms of recombinant Sml1p-histag protein by electrospray mass spectrometry. Analytical Biochemistry. 301: 35-48. PMID 11811965 DOI: 10.1006/abio.2001.5492  0.56
Show low-probability matches.