Marcos E. Milla - Publications

Affiliations: 
University of Pennsylvania, Philadelphia, PA, United States 
Area:
Biochemistry

34 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Myagmar BE, Ismaili T, Swigart P, Raghunathan A, Baker AJ, Sahdeo S, Blevitt JM, Milla ME, Simpson PC. Coupling to Gq Signaling Is Required for Cardioprotection by an Alpha-1A-Adrenergic Receptor Agonist. Circulation Research. PMID 31426700 DOI: 10.1161/CIRCRESAHA.118.314416  1
2017 Blevitt JM, Hack MD, Herman KL, Jackson PF, Krawczuk PJ, Lebsack AD, Liu AX, Mirzadegan T, Nelen MI, Patrick AN, Steinbacher S, Milla ME, Lumb KJ. Structural Basis of Small-Molecule Aggregate Induced Inhibition of a Protein-Protein Interaction. Journal of Medicinal Chemistry. PMID 28300404 DOI: 10.1021/Acs.Jmedchem.6B01836  1
2016 Wong E, Cohen T, Romi E, Levin M, Peleg Y, Arad U, Yaron A, Milla ME, Sagi I. Harnessing the natural inhibitory domain to control TNFα Converting Enzyme (TACE) activity in vivo. Scientific Reports. 6: 35598. PMID 27982031 DOI: 10.1038/Srep35598  1
2016 Blevitt JM, Hack MD, Herman K, Chang L, Keith JM, Mirzadegan T, Rao NL, Lebsack AD, Milla ME. A Single Amino Acid Difference between Mouse and Human 5-lipoxygenase Activating Protein (FLAP) Explains the Speciation and Differential Pharmacology of Novel FLAP Inhibitors. The Journal of Biological Chemistry. PMID 27129215 DOI: 10.1074/jbc.M116.725325  1
2015 Song J, Liu X, Zhu J, Tootoonchi M, Keith JM, Meduna SP, Dvorak CA, Eccles W, Krawczuk PJ, Blevitt JM, Wu J, Rao NL, Lebsack AD, Milla ME. Polypharmacology of Small-Molecule Modulators of the 5-Lipoxygenase Activating Protein (FLAP) Observed via a High-throughput Lipidomics Platform. Journal of Biomolecular Screening. PMID 26442913 DOI: 10.1177/1087057115607815  1
2015 Song J, Liu X, Rao TS, Chang L, Meehan MJ, Blevitt JM, Wu J, Dorrestein PC, Milla ME. Phenotyping Drug Polypharmacology via Eicosanoid Profiling of Blood. Journal of Lipid Research. PMID 26022804 DOI: 10.1194/Jlr.M058677  1
2015 Rex EB, Kim S, Wiener J, Rao NL, Milla ME, DiSepio D. Phenotypic Approaches to Identify Inhibitors of B Cell Activation. Journal of Biomolecular Screening. 20: 876-86. PMID 25948491 DOI: 10.1177/1087057115585724  0.24
2015 Copik AJ, Baldys A, Nguyen K, Sahdeo S, Ho H, Kosaka A, Dietrich PJ, Fitch B, Raymond JR, Ford AP, Button D, Milla ME. Isoproterenol acts as a biased agonist of the alpha-1A-adrenoceptor that selectively activates the MAPK/ERK pathway. Plos One. 10: e0115701. PMID 25606852 DOI: 10.1371/journal.pone.0115701  1
2015 Rex EB, Kim S, Wiener J, Rao NL, Milla ME, Disepio D. Phenotypic approaches to identify inhibitors of B cell activation Journal of Biomolecular Screening. 20: 876-886. DOI: 10.1177/1087057115585724  1
2014 Soroosh P, Wu J, Xue X, Song J, Sutton SW, Sablad M, Yu J, Nelen MI, Liu X, Castro G, Luna R, Crawford S, Banie H, Dandridge RA, Deng X, ... ... Milla ME, et al. Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiation. Proceedings of the National Academy of Sciences of the United States of America. 111: 12163-8. PMID 25092323 DOI: 10.1073/pnas.1322807111  1
2014 Sahdeo S, Wallace T, Hirakawa R, Knoflach F, Bertrand D, Maag H, Misner D, Tombaugh GC, Santarelli L, Brameld K, Milla ME, Button DC. Characterization of RO5126946, a Novel α7 nicotinic acetylcholine receptor-positive allosteric modulator. The Journal of Pharmacology and Experimental Therapeutics. 350: 455-68. PMID 24917542 DOI: 10.1124/Jpet.113.210963  1
2013 Song J, Liu X, Wu J, Meehan MJ, Blevitt JM, Dorrestein PC, Milla ME. A highly efficient, high-throughput lipidomics platform for the quantitative detection of eicosanoids in human whole blood. Analytical Biochemistry. 433: 181-8. PMID 23103340 DOI: 10.1016/J.Ab.2012.10.022  1
2012 Rath CM, Alexandrov T, Higginbottom SK, Song J, Milla ME, Fischbach MA, Sonnenburg JL, Dorrestein PC. Molecular analysis of model gut microbiotas by imaging mass spectrometry and nanodesorption electrospray ionization reveals dietary metabolite transformations. Analytical Chemistry. 84: 9259-67. PMID 23009651 DOI: 10.1021/Ac302039U  1
2010 Gever JR, Soto R, Henningsen RA, Martin RS, Hackos DH, Panicker S, Rubas W, Oglesby IB, Dillon MP, Milla ME, Burnstock G, Ford AP. AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist. British Journal of Pharmacology. 160: 1387-98. PMID 20590629 DOI: 10.1111/J.1476-5381.2010.00796.X  1
2009 Copik AJ, Ma C, Kosaka A, Sahdeo S, Trane A, Ho H, Dietrich PS, Yu H, Ford AP, Button D, Milla ME. Facilitatory interplay in alpha 1a and beta 2 adrenoceptor function reveals a non-Gq signaling mode: implications for diversification of intracellular signal transduction. Molecular Pharmacology. 75: 713-28. PMID 19109357 DOI: 10.1124/mol.108.050765  1
2008 Kim ML, Zhang B, Mills IP, Milla ME, Brunden KR, Lee VM. Effects of TNFalpha-converting enzyme inhibition on amyloid beta production and APP processing in vitro and in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 12052-61. PMID 19005070 DOI: 10.1523/Jneurosci.2913-08.2008  1
2008 Martin RS, Henningsen RA, Suen A, Apparsundaram S, Leung B, Jia Z, Kondru RK, Milla ME. Kinetic and thermodynamic assessment of binding of serotonin transporter inhibitors. The Journal of Pharmacology and Experimental Therapeutics. 327: 991-1000. PMID 18801948 DOI: 10.1124/Jpet.108.142307  1
2008 Apparsundaram S, Stockdale DJ, Henningsen RA, Milla ME, Martin RS. Antidepressants targeting the serotonin reuptake transporter act via a competitive mechanism. The Journal of Pharmacology and Experimental Therapeutics. 327: 982-90. PMID 18801947 DOI: 10.1124/jpet.108.142315  1
2008 Gonzales PE, Galli JD, Milla ME. Identification of key sequence determinants for the inhibitory function of the prodomain of TACE. Biochemistry. 47: 9911-9. PMID 18707126 DOI: 10.1021/Bi801049V  1
2008 Sagi I, Milla ME. Application of structural dynamic approaches provide novel insights into the enzymatic mechanism of the tumor necrosis factor-alpha-converting enzyme. Analytical Biochemistry. 372: 1-10. PMID 17963710 DOI: 10.1016/J.Ab.2007.07.037  1
2007 Solomon A, Akabayov B, Frenkel A, Milla ME, Sagi I. Key feature of the catalytic cycle of TNF-alpha converting enzyme involves communication between distal protein sites and the enzyme catalytic core. Proceedings of the National Academy of Sciences of the United States of America. 104: 4931-6. PMID 17360351 DOI: 10.1073/Pnas.0700066104  1
2007 Zhu L, Bergmeier W, Wu J, Jiang H, Stalker TJ, Cieslak M, Fan R, Boumsell L, Kumanogoh A, Kikutani H, Tamagnone L, Wagner DD, Milla ME, Brass LF. Regulated surface expression and shedding support a dual role for semaphorin 4D in platelet responses to vascular injury. Proceedings of the National Academy of Sciences of the United States of America. 104: 1621-6. PMID 17244710 DOI: 10.1073/Pnas.0606344104  1
2006 Milla ME, Gonzales PE, Leonard JD. The TACE zymogen: re-examining the role of the cysteine switch. Cell Biochemistry and Biophysics. 44: 342-8. PMID 16679521 DOI: 10.1385/Cbb:44:3:342  1
2005 Schneeweis LA, Willard D, Milla ME. Functional dissection of osteoprotegerin and its interaction with receptor activator of NF-kappaB ligand. The Journal of Biological Chemistry. 280: 41155-64. PMID 16215261 DOI: 10.1074/jbc.M506366200  0.01
2005 Leonard JD, Lin F, Milla ME. Chaperone-like properties of the prodomain of TNFalpha-converting enzyme (TACE) and the functional role of its cysteine switch. The Biochemical Journal. 387: 797-805. PMID 15581423 DOI: 10.1042/BJ20041727  1
2004 Solomon A, Rosenblum G, Gonzales PE, Leonard JD, Mobashery S, Milla ME, Sagi I. Pronounced diversity in electronic and chemical properties between the catalytic zinc sites of tumor necrosis factor-α-converting enzyme and matrix metalloproteinases despite their high structural similarity Journal of Biological Chemistry. 279: 31646-31654. PMID 15102849 DOI: 10.1074/Jbc.M401310200  1
2004 Gonzales PE, Solomon A, Miller AB, Leesnitzer MA, Sagi I, Milla ME. Inhibition of the tumor necrosis factor-alpha-converting enzyme by its pro domain. The Journal of Biological Chemistry. 279: 31638-45. PMID 15100227 DOI: 10.1074/Jbc.M401311200  1
2003 Hinkle CL, Mohan MJ, Lin P, Yeung N, Rasmussen F, Milla ME, Moss ML. Multiple metalloproteinases process protransforming growth factor-alpha (proTGF-alpha). Biochemistry. 42: 2127-36. PMID 12590602 DOI: 10.1021/Bi026709V  1
2002 Mohan MJ, Seaton T, Mitchell J, Howe A, Blackburn K, Burkhart W, Moyer M, Patel I, Waitt GM, Becherer JD, Moss ML, Milla ME. The tumor necrosis factor-alpha converting enzyme (TACE): a unique metalloproteinase with highly defined substrate selectivity. Biochemistry. 41: 9462-9. PMID 12135369 DOI: 10.1021/Bi0260132  1
2000 Skovronsky DM, Moore DB, Milla ME, Doms RW, Lee VM. Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network. The Journal of Biological Chemistry. 275: 2568-75. PMID 10644715 DOI: 10.1074/Jbc.275.4.2568  1
1999 Milla ME, Leesnitzer MA, Moss ML, Clay WC, Carter HL, Miller AB, Su JL, Lambert MH, Willard DH, Sheeley DM, Kost TA, Burkhart W, Moyer M, Blackburn RK, Pahel GL, et al. Specific sequence elements are required for the expression of functional tumor necrosis factor-alpha-converting enzyme (TACE). The Journal of Biological Chemistry. 274: 30563-70. PMID 10521439 DOI: 10.1074/jbc.274.43.30563  1
1996 Sauer RT, Milla ME, Waldburger CD, Brown BM, Schildbach JF. Sequence determinants of folding and stability for the P22 Arc repressor dimer Faseb Journal. 10: 42-48. PMID 8566546 DOI: 10.1096/Fasebj.10.1.8566546  1
1995 Milla ME, Sauer RT. Critical side-chain interactions at a subunit interface in the Arc repressor dimer Biochemistry. 34: 3344-3351. PMID 7880830 DOI: 10.1021/Bi00010A025  1
1995 Milla ME, Brown BM, Waldburger CD, Sauer RT. P22 Arc repressor: Transition state properties inferred from mutational effects on the rates of protein unfolding and refolding Biochemistry. 34: 13914-13919. PMID 7577986 DOI: 10.1021/Bi00042A024  1
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