Xiang-Dong Wang - Publications

Affiliations: 
Tufts University, Boston 
Area:
Nutrition, Molecular Biology, Biochemistry

67 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Rakic JM, Liu C, Veeramachaneni S, Wu D, Paul L, Chen O, Ausman L, Wang XD. Modulation of Reverse Cholesterol Transport by Lycopene Is Associated with Its Protective Role Against Cigarette Smoke Induced COPD and Lung Carcinogenesis in Ferrets (OR05-02-19). Current Developments in Nutrition. 3. PMID 31224941 DOI: 10.1093/cdn/nzz029.OR05-02-19  1
2019 Wang XD, Hu KQ, Liu C, McBurney M. Ablation of Sirtuin 1 Deacetylase Activity Induces Pulmonary Emphysema by Inducing Cellular Senescence and Disrupting Circadian Clock in Mice (P01-022-19). Current Developments in Nutrition. 3. PMID 31224297 DOI: 10.1093/cdn/nzz028.P01-022-19  0.48
2019 Lim JY, Liu C, Hu KQ, Smith DE, Wu D, Lamon-Fava S, Ausman L, Wang XD. β-Cryptoxanthin Prevents Non-alcoholic Fatty Liver Disease Through Different Mechanisms Depending on the Presence or Absence of Carotenoid Cleavage Enzymes (FS06-03-192). Current Developments in Nutrition. 3. PMID 31224262 DOI: 10.1093/cdn/nzz029.FS06-03-192  0.48
2019 Lim JY, Liu C, Hu KQ, Smith DE, Wu D, Lamon-Fava S, Ausman LM, Wang XD. Dietary β-Cryptoxanthin Inhibits High-Refined Carbohydrate Diet-Induced Fatty Liver via Differential Protective Mechanisms Depending on Carotenoid Cleavage Enzymes in Male Mice. The Journal of Nutrition. PMID 31212314 DOI: 10.1093/jn/nxz106  0.48
2019 Mustra Rakic J, Liu C, Veeramachaneni S, Wu D, Paul L, Chen CO, Ausman LM, Wang XD. Lycopene Inhibits Smoke-Induced Chronic Obstructive Pulmonary Disease and Lung Carcinogenesis by Modulating Reverse Cholesterol Transport in Ferrets. Cancer Prevention Research (Philadelphia, Pa.). PMID 31177203 DOI: 10.1158/1940-6207.CAPR-19-0063  1
2018 Xia H, Liu C, Li CC, Fu M, Takahashi S, Hu KQ, Aizawa K, Hiroyuki S, Wu G, Zhao L, Wang XD. Dietary Tomato Powder Inhibits High-Fat Diet-Promoted Hepatocellular Carcinoma with Alteration of Gut Microbiota in Mice Lacking Carotenoid Cleavage Enzymes. Cancer Prevention Research (Philadelphia, Pa.). PMID 30446518 DOI: 10.1158/1940-6207.CAPR-18-0188  0.48
2018 Qin DD, Yang YF, Pu ZQ, Liu D, Yu C, Gao P, Chen JC, Zong C, Zhang YC, Li X, Wang XD, Liu YT. NR4A1 retards adipocyte differentiation or maturation via enhancing GATA2 and p53 expression. Journal of Cellular and Molecular Medicine. PMID 30044048 DOI: 10.1111/jcmm.13715  0.4
2018 Lim JY, Liu C, Hu KQ, Smith DE, Wang XD. Ablation of carotenoid cleavage enzymes (BCO1 and BCO2) induced hepatic steatosis by altering the farnesoid X receptor/miR-34a/sirtuin 1 pathway. Archives of Biochemistry and Biophysics. PMID 30006135 DOI: 10.1016/j.abb.2018.07.007  0.48
2018 Qu J, Liu C, Lian HH, Wang XD, Zhi N. Qingfeijianpi therapy for persistent allergic rhinitis: A randomized, positive-controlled clinical trial. Medicine. 97: e10961. PMID 29879045 DOI: 10.1097/MD.0000000000010961  0.48
2018 Cheng J, Miao B, Hu KQ, Fu X, Wang XD. Apo-10'-lycopenoic acid inhibits cancer cell migration and angiogenesis and induces peroxisome proliferator-activated receptor γ. The Journal of Nutritional Biochemistry. 56: 26-34. PMID 29454996 DOI: 10.1016/j.jnutbio.2018.01.003  0.4
2017 Li CC, Liu C, Fu M, Hu KQ, Aizawa K, Takahashi S, Hiroyuki S, Cheng J, von Lintig J, Wang XD. Tomato Powder Inhibits Hepatic Steatosis and Inflammation Potentially Through Restoring SIRT1 Activity and Adiponectin Function Independent of Carotenoid Cleavage Enzymes in Mice. Molecular Nutrition & Food Research. PMID 29266812 DOI: 10.1002/mnfr.201700738  0.48
2017 Cheng J, Liu C, Hu K, Greenberg A, Wu D, Ausman LM, McBurney MW, Wang XD. Ablation of systemic SIRT1 activity promotes nonalcoholic fatty liver disease by affecting liver-mesenteric adipose tissue fatty acid mobilization. Biochimica Et Biophysica Acta. PMID 28789977 DOI: 10.1016/j.bbadis.2017.08.004  0.48
2016 Iskandar AR, Miao B, Li X, Hu KQ, Liu C, Wang XD. β-Cryptoxanthin reduced lung tumor multiplicity and inhibited lung cancer cells motility by down-regulating nicotinic acetylcholine receptor α7 expression. Cancer Prevention Research (Philadelphia, Pa.). PMID 27623933 DOI: 10.1158/1940-6207.CAPR-16-0161  0.48
2016 Aizawa K, Liu C, Tang S, Veeramachaneni S, Hu KQ, Smith DE, Wang XD. Tobacco carcinogen (NNK) induces both lung cancer and non-alcoholic steatohepatitis and hepatocellular carcinomas in ferrets which can be attenuated by lycopene supplementation. International Journal of Cancer. PMID 27116542 DOI: 10.1002/ijc.30161  1
2016 Stice CP, Hussain S, Liu C, Ausman LM, Wang XD, Greenberg AS. Deletion of tumor progression locus 2 attenuates alcohol-induced hepatic inflammation. Hepatobiliary Surgery and Nutrition. 5: 29-37. PMID 26904554 DOI: 10.3978/j.issn.2304-3881.2015.12.11  0.48
2015 Li X, Lian F, Liu C, Hu KQ, Wang XD. Isocaloric Pair-Fed High-Carbohydrate Diet Induced More Hepatic Steatosis and Inflammation than High-Fat Diet Mediated by miR-34a/SIRT1 Axis in Mice. Scientific Reports. 5: 16774. PMID 26608583 DOI: 10.1038/srep16774  1
2015 Li X, Liu C, Ip BC, Hu KQ, Smith DE, Greenberg AS, Wang XD. Tumor progression locus 2 ablation suppressed hepatocellular carcinoma development by inhibiting hepatic inflammation and steatosis in mice. Journal of Experimental & Clinical Cancer Research : Cr. 34: 138. PMID 26560698 DOI: 10.1186/s13046-015-0254-2  1
2015 Rafacho BP, Stice CP, Liu C, Greenberg AS, Ausman LM, Wang XD. Inhibition of diethylnitrosamine-initiated alcohol-promoted hepatic inflammation and precancerous lesions by flavonoid luteolin is associated with increased sirtuin 1 activity in mice. Hepatobiliary Surgery and Nutrition. 4: 124-34. PMID 26005679 DOI: 10.3978/j.issn.2304-3881.2014.08.06  0.48
2015 Ling Y, Jing M, Wang XD. Allosteric therapies for lung cancer. Cancer Metastasis Reviews. 34: 303-12. PMID 25951982 DOI: 10.1007/s10555-015-9567-z  1
2015 Ip BC, Liu C, Lichtenstein AH, von Lintig J, Wang XD. Lycopene and apo-10'-lycopenoic acid have differential mechanisms of protection against hepatic steatosis in β-carotene-9',10'-oxygenase knockout male mice. The Journal of Nutrition. 145: 268-76. PMID 25644347 DOI: 10.3945/jn.114.200238  1
2015 Stice CP, Liu C, Aizawa K, Greenberg AS, Ausman LM, Wang XD. Dietary tomato powder inhibits alcohol-induced hepatic injury by suppressing cytochrome p450 2E1 induction in rodent models. Archives of Biochemistry and Biophysics. 572: 81-8. PMID 25592162 DOI: 10.1016/j.abb.2015.01.004  1
2015 Wang JW, Gong XH, Ding N, Chen XF, Sun L, Tang Z, Yu DH, Yuan ZP, Wang XD, Yu JM. The influence of comorbid chronic diseases and physical activity on quality of life in lung cancer survivors. Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer. 23: 1383-9. PMID 25358644 DOI: 10.1007/s00520-014-2494-7  1
2014 Ip BC, Liu C, Ausman LM, von Lintig J, Wang XD. Lycopene attenuated hepatic tumorigenesis via differential mechanisms depending on carotenoid cleavage enzyme in mice. Cancer Prevention Research (Philadelphia, Pa.). 7: 1219-27. PMID 25293877 DOI: 10.1158/1940-6207.CAPR-14-0154  1
2014 Ip BC, Liu C, Smith DE, Ausman LM, Wang XD. High-refined-carbohydrate and high-fat diets induce comparable hepatic tumorigenesis in male mice. The Journal of Nutrition. 144: 647-53. PMID 24647392 DOI: 10.3945/jn.113.189613  1
2014 Ip BC, Wang XD. Non-alcoholic steatohepatitis and hepatocellular carcinoma: implications for lycopene intervention. Nutrients. 6: 124-62. PMID 24379011 DOI: 10.3390/nu6010124  1
2013 Nascimento AF, Ip BC, Luvizotto RA, Seitz HK, Wang XD. Aggravation of nonalcoholic steatohepatitis by moderate alcohol consumption is associated with decreased SIRT1 activity in rats. Hepatobiliary Surgery and Nutrition. 2: 252-9. PMID 24570955 DOI: 10.3978/j.issn.2304-3881.2013.07.05  0.36
2013 Aizawa K, Liu C, Veeramachaneni S, Hu KQ, Smith DE, Wang XD. Development of ferret as a human lung cancer model by injecting 4-(Nmethyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Lung Cancer (Amsterdam, Netherlands). 82: 390-6. PMID 24396883 DOI: 10.1016/j.lungcan.2013.09.012  1
2013 Melendez-Martinez AJ, Nascimento AF, Wang Y, Liu C, Mao Y, Wang XD. Effect of tomato extract supplementation against high-fat diet-induced hepatic lesions. Hepatobiliary Surgery and Nutrition. 2: 198-208. PMID 24273751  0.48
2013 Ip BC, Hu KQ, Liu C, Smith DE, Obin MS, Ausman LM, Wang XD. Lycopene metabolite, apo-10'-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice. Cancer Prevention Research (Philadelphia, Pa.). 6: 1304-16. PMID 24085778 DOI: 10.1158/1940-6207.CAPR-13-0178  1
2013 Melendez-Martinez AJ, Stinco CM, Liu C, Wang XD. A simple HPLC method for the comprehensive analysis of cis/trans (Z/E) geometrical isomers of carotenoids for nutritional studies. Food Chemistry. 138: 1341-50. PMID 23411252 DOI: 10.1016/j.foodchem.2012.10.067  0.48
2013 Iskandar AR, Liu C, Smith DE, Hu KQ, Choi SW, Ausman LM, Wang XD. β-cryptoxanthin restores nicotine-reduced lung SIRT1 to normal levels and inhibits nicotine-promoted lung tumorigenesis and emphysema in A/J mice. Cancer Prevention Research (Philadelphia, Pa.). 6: 309-20. PMID 23275008 DOI: 10.1158/1940-6207.CAPR-12-0368  1
2012 Ye Q, Lian F, Chavez PR, Chung J, Ling W, Qin H, Seitz HK, Wang XD. Cytochrome P450 2E1 inhibition prevents hepatic carcinogenesis induced by diethylnitrosamine in alcohol-fed rats. Hepatobiliary Surgery and Nutrition. 1: 5-18. PMID 23543859 DOI: 10.3978/j.issn.2304-3881.2012.11.05  1
2012 Chung J, Koo K, Lian F, Hu KQ, Ernst H, Wang XD. Apo-10'-lycopenoic acid, a lycopene metabolite, increases sirtuin 1 mRNA and protein levels and decreases hepatic fat accumulation in ob/ob mice. The Journal of Nutrition. 142: 405-10. PMID 22259190 DOI: 10.3945/jn.111.150052  1
2012 Kim Y, Chongviriyaphan N, Liu C, Russell RM, Wang XD. Combined α-tocopherol and ascorbic acid protects against smoke-induced lung squamous metaplasia in ferrets. Lung Cancer (Amsterdam, Netherlands). 75: 15-23. PMID 21665318 DOI: 10.1016/j.lungcan.2011.05.017  0.48
2011 Chavez PR, Lian F, Chung J, Liu C, Paiva SA, Seitz HK, Wang XD. Long-term ethanol consumption promotes hepatic tumorigenesis but impairs normal hepatocyte proliferation in rats. The Journal of Nutrition. 141: 1049-55. PMID 21490289 DOI: 10.3945/jn.110.136531  1
2011 Nascimento AF, Luvizotto RA, Leopoldo AS, Lima-Leopoldo AP, Seiva FR, Justulin LA, Silva MD, Okoshi K, Wang XD, Cicogna AC. Long-term high-fat diet-induced obesity decreases the cardiac leptin receptor without apparent lipotoxicity. Life Sciences. 88: 1031-8. PMID 21457721 DOI: 10.1016/j.lfs.2011.03.015  0.36
2011 Liu C, Bronson RT, Russell RM, Wang XD. β-Cryptoxanthin supplementation prevents cigarette smoke-induced lung inflammation, oxidative damage, and squamous metaplasia in ferrets. Cancer Prevention Research (Philadelphia, Pa.). 4: 1255-66. PMID 21421799 DOI: 10.1158/1940-6207.CAPR-10-0384  1
2011 Mein JR, Dolnikowski GG, Ernst H, Russell RM, Wang XD. Enzymatic formation of apo-carotenoids from the xanthophyll carotenoids lutein, zeaxanthin and β-cryptoxanthin by ferret carotene-9',10'-monooxygenase. Archives of Biochemistry and Biophysics. 506: 109-21. PMID 21081106 DOI: 10.1016/j.abb.2010.11.005  0.48
2010 Luvizotto RA, Nascimento AF, Veeramachaneni S, Liu C, Wang XD. Chronic alcohol intake upregulates hepatic expression of carotenoid cleavage enzymes and PPAR in rats. The Journal of Nutrition. 140: 1808-14. PMID 20702748 DOI: 10.3945/jn.110.123398  1
2010 Zhang Y, Lian F, Zhu Y, Xia M, Wang Q, Ling W, Wang XD. Cyanidin-3-O-beta-glucoside inhibits LPS-induced expression of inflammatory mediators through decreasing IkappaBalpha phosphorylation in THP-1 cells. Inflammation Research : Official Journal of the European Histamine Research Society ... [Et Al.]. 59: 723-30. PMID 20309718 DOI: 10.1007/s00011-010-0183-7  1
2010 Wang Y, Ausman LM, Greenberg AS, Russell RM, Wang XD. Dietary lycopene and tomato extract supplementations inhibit nonalcoholic steatohepatitis-promoted hepatocarcinogenesis in rats. International Journal of Cancer. Journal International Du Cancer. 126: 1788-96. PMID 19551842 DOI: 10.1002/ijc.24689  1
2009 Chung J, Veeramachaneni S, Liu C, Mernitz H, Russell RM, Wang XD. Vitamin E supplementation does not prevent ethanol-reduced hepatic retinoic acid levels in rats. Nutrition Research (New York, N.Y.). 29: 664-70. PMID 19854382 DOI: 10.1016/j.nutres.2009.09.008  1
2009 Mernitz H, Lian F, Smith DE, Meydani SN, Wang XD. Fish oil supplementation inhibits NNK-induced lung carcinogenesis in the A/J mouse. Nutrition and Cancer. 61: 663-9. PMID 19838940 DOI: 10.1080/01635580902825589  1
2009 Veeramachaneni S, Wang XD. Carotenoids and lung cancer prevention. Frontiers in Bioscience (Scholar Edition). 1: 258-74. PMID 19482701  1
2009 Liu C, Wang XD, Mucci L, Gaziano JM, Zhang SM. Modulation of lung molecular biomarkers by beta-carotene in the Physicians' Health Study. Cancer. 115: 1049-58. PMID 19142877 DOI: 10.1002/cncr.24061  0.48
2009 Wang Y, Ausman LM, Greenberg AS, Russell RM, Wang XD. Nonalcoholic steatohepatitis induced by a high-fat diet promotes diethylnitrosamine-initiated early hepatocarcinogenesis in rats. International Journal of Cancer. Journal International Du Cancer. 124: 540-6. PMID 19004024 DOI: 10.1002/ijc.23995  1
2008 Fu X, Wang XD, Mernitz H, Wallin R, Shea MK, Booth SL. 9-Cis retinoic acid reduces 1alpha,25-dihydroxycholecalciferol-induced renal calcification by altering vitamin K-dependent gamma-carboxylation of matrix gamma-carboxyglutamic acid protein in A/J male mice. The Journal of Nutrition. 138: 2337-41. PMID 19022954 DOI: 10.3945/jn.108.093724  0.48
2008 Mein JR, Lian F, Wang XD. Biological activity of lycopene metabolites: implications for cancer prevention. Nutrition Reviews. 66: 667-83. PMID 19019036 DOI: 10.1111/j.1753-4887.2008.00120.x  1
2008 Wang Y, Ausman LM, Russell RM, Greenberg AS, Wang XD. Increased apoptosis in high-fat diet-induced nonalcoholic steatohepatitis in rats is associated with c-Jun NH2-terminal kinase activation and elevated proapoptotic Bax. The Journal of Nutrition. 138: 1866-71. PMID 18806094  1
2008 Veeramachaneni S, Ausman LM, Choi SW, Russell RM, Wang XD. High dose lycopene supplementation increases hepatic cytochrome P4502E1 protein and inflammation in alcohol-fed rats. The Journal of Nutrition. 138: 1329-35. PMID 18567756  1
2008 Lian F, Wang XD. Enzymatic metabolites of lycopene induce Nrf2-mediated expression of phase II detoxifying/antioxidant enzymes in human bronchial epithelial cells. International Journal of Cancer. 123: 1262-8. PMID 18566994 DOI: 10.1002/ijc.23696  1
2007 Lian F, Smith DE, Ernst H, Russell RM, Wang XD. Apo-10'-lycopenoic acid inhibits lung cancer cell growth in vitro, and suppresses lung tumorigenesis in the A/J mouse model in vivo. Carcinogenesis. 28: 1567-74. PMID 17420169 DOI: 10.1093/carcin/bgm076  1
2007 Kim Y, Lian F, Yeum KJ, Chongviriyaphan N, Choi SW, Russell RM, Wang XD. The effects of combined antioxidant (beta-carotene, alpha-tocopherol and ascorbic acid) supplementation on antioxidant capacity, DNA single-strand breaks and levels of insulin-like growth factor-1/IGF-binding protein 3 in the ferret model of lung cancer. International Journal of Cancer. Journal International Du Cancer. 120: 1847-54. PMID 17278094 DOI: 10.1002/ijc.22320  1
2007 Mernitz H, Smith DE, Wood RJ, Russell RM, Wang XD. Inhibition of lung carcinogenesis by 1alpha,25-dihydroxyvitamin D3 and 9-cis retinoic acid in the A/J mouse model: evidence of retinoid mitigation of vitamin D toxicity. International Journal of Cancer. Journal International Du Cancer. 120: 1402-9. PMID 17205520 DOI: 10.1002/ijc.22462  0.48
2006 Lian F, Hu KQ, Russell RM, Wang XD. Beta-cryptoxanthin suppresses the growth of immortalized human bronchial epithelial cells and non-small-cell lung cancer cells and up-regulates retinoic acid receptor beta expression. International Journal of Cancer. 119: 2084-9. PMID 16841329 DOI: 10.1002/ijc.22111  1
2006 Hu KQ, Liu C, Ernst H, Krinsky NI, Russell RM, Wang XD. The biochemical characterization of ferret carotene-9',10'-monooxygenase catalyzing cleavage of carotenoids in vitro and in vivo. The Journal of Biological Chemistry. 281: 19327-38. PMID 16672231 DOI: 10.1074/jbc.M512095200  0.48
2006 Mernitz H, Smith DE, Zhu AX, Wang XD. 9-cis-Retinoic acid inhibition of lung carcinogenesis in the A/J mouse model is accompanied by increased expression of RAR-beta but no change in cyclooxygenase-2. Cancer Letters. 244: 101-8. PMID 16413115 DOI: 10.1016/j.canlet.2005.12.001  0.48
2006 Kim Y, Chongviriyaphan N, Liu C, Russell RM, Wang XD. Combined antioxidant (beta-carotene, alpha-tocopherol and ascorbic acid) supplementation increases the levels of lung retinoic acid and inhibits the activation of mitogen-activated protein kinase in the ferret lung cancer model. Carcinogenesis. 27: 1410-9. PMID 16401635 DOI: 10.1093/carcin/bgi340  0.48
2006 Liu C, Russell RM, Wang XD. Lycopene supplementation prevents smoke-induced changes in p53, p53 phosphorylation, cell proliferation, and apoptosis in the gastric mucosa of ferrets. The Journal of Nutrition. 136: 106-11. PMID 16365067  0.48
2006 Kim Y, Liu XS, Liu C, Smith DE, Russell RM, Wang XD. Induction of pulmonary neoplasia in the smoke-exposed ferret by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK): a model for human lung cancer. Cancer Letters. 234: 209-19. PMID 15894421 DOI: 10.1016/j.canlet.2005.03.052  0.48
2005 Dan Z, Popov Y, Patsenker E, Preimel D, Liu C, Wang XD, Seitz HK, Schuppan D, Stickel F. Hepatotoxicity of alcohol-induced polar retinol metabolites involves apoptosis via loss of mitochondrial membrane potential. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 19: 845-7. PMID 15731294 DOI: 10.1096/fj.04-2809fje  0.48
2004 Lian F, Chung J, Russell RM, Wang XD. Alcohol-reduced plasma IGF-I levels and hepatic IGF-I expression can be partially restored by retinoic acid supplementation in rats. The Journal of Nutrition. 134: 2953-6. PMID 15514258  1
2004 Liu C, Russell RM, Wang XD. Low dose beta-carotene supplementation of ferrets attenuates smoke-induced lung phosphorylation of JNK, p38 MAPK, and p53 proteins. The Journal of Nutrition. 134: 2705-10. PMID 15465770  0.48
2004 Liu C, Russell RM, Smith DE, Bronson RT, Milbury PE, Furukawa S, Wang XD, Blumberg JB. The effect of dietary glutathione and coenzyme Q10 on the prevention and treatment of inflammatory bowel disease in mice. International Journal For Vitamin and Nutrition Research. Internationale Zeitschrift FüR Vitamin- Und ErnäHrungsforschung. Journal International De Vitaminologie Et De Nutrition. 74: 74-85. PMID 15060903 DOI: 10.1024/0300-9831.74.1.74  0.48
2004 Prakash P, Liu C, Hu KQ, Krinsky NI, Russell RM, Wang XD. Beta-carotene and beta-apo-14'-carotenoic acid prevent the reduction of retinoic acid receptor beta in benzo[a]pyrene-treated normal human bronchial epithelial cells. The Journal of Nutrition. 134: 667-73. PMID 14988465  0.48
2004 Liu C, Russell RM, Wang XD. Alpha-tocopherol and ascorbic acid decrease the production of beta-apo-carotenals and increase the formation of retinoids from beta-carotene in the lung tissues of cigarette smoke-exposed ferrets in vitro. The Journal of Nutrition. 134: 426-30. PMID 14747683  0.48
2003 Liu C, Lian F, Smith DE, Russell RM, Wang XD. Lycopene supplementation inhibits lung squamous metaplasia and induces apoptosis via up-regulating insulin-like growth factor-binding protein 3 in cigarette smoke-exposed ferrets. Cancer Research. 63: 3138-44. PMID 12810641  1
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