Stephen Safe - Publications

Affiliations: 
Texas A & M University, College Station, TX, United States 
Area:
Molecular Biology, Biochemistry

232 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Jin UH, Karki K, Cheng Y, Michelhaugh SK, Mittal S, Safe S. The aryl hydrocarbon receptor is a tumor suppressor-like gene in glioblastoma. The Journal of Biological Chemistry. PMID 31171720 DOI: 10.1074/jbc.RA119.008882  0.96
2019 Hedrick E, Li X, Cheng Y, Lacey A, Mohankumar K, Zarei M, Safe S. Potent inhibition of breast cancer by bis-indole-derived nuclear receptor 4A1 (NR4A1) antagonists. Breast Cancer Research and Treatment. PMID 31119568 DOI: 10.1007/s10549-019-05279-9  0.88
2019 Li X, Tjalkens RB, Shrestha R, Safe S. Structure-dependent Activation of Gene Expression by Bis-indole and Quinoline-derived Activators of Nuclear Receptor 4A2. Chemical Biology & Drug Design. PMID 31102570 DOI: 10.1111/cbdd.13564  0.76
2019 Mohankumar K, Li X, Sridharan S, Karki K, Safe S. Nuclear receptor 4A1 (NR4A1) antagonists induce ROS-dependent inhibition of mTOR signaling in endometrial cancer. Gynecologic Oncology. PMID 31053403 DOI: 10.1016/j.ygyno.2019.04.678  0.88
2019 Yoon K, Chen CC, Orr AA, Barreto PN, Tamamis P, Safe S. Activation of COUP-TFI by a Novel Diindolylmethane Derivative. Cells. 8. PMID 30866413 DOI: 10.3390/cells8030220  0.84
2019 Kasiappan R, Jutooru I, Mohankumar K, Karki K, Lacey A, Safe S. Reactive Oxygen Species (ROS)-inducing Triterpenoid Inhibits Rhabdomyosarcoma Cell and Tumor Growth through Targeting Sp Transcription Factors. Molecular Cancer Research : McR. PMID 30610105 DOI: 10.1158/1541-7786.MCR-18-1071  0.88
2018 Jung YS, Lee HS, Cho HR, Kim KJ, Kim JH, Safe S, Lee SO. Dual targeting of Nur77 and AMPKα by isoalantolactone inhibits adipogenesis in vitro and decreases body fat mass in vivo. International Journal of Obesity (2005). PMID 30538281 DOI: 10.1038/s41366-018-0276-x  0.96
2018 Wu CS, Wei Q, Wang H, Kim DM, Balderas M, Wu G, Lawler J, Safe S, Guo S, Devaraj S, Chen Z, Sun Y. Protective effects of ghrelin on fasting-induced muscle atrophy in aging mice. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. PMID 30407483 DOI: 10.1093/gerona/gly256  0.88
2018 Lacey A, Hedrick E, Cheng Y, Mohankumar K, Warren M, Safe S. Interleukin-24 (IL-24) Is Suppressed By PAX3-FOXO1 and Is A Novel Therapy For Rhabdomyosarcoma. Molecular Cancer Therapeutics. PMID 30190424 DOI: 10.1158/1535-7163.MCT-18-0118  0.88
2018 Karki K, Harishchandra S, Safe SH. Bortezomib Targets Sp Transcription Factors in Cancer Cells. Molecular Pharmacology. PMID 30115673 DOI: 10.1124/mol.118.112797  0.84
2018 Popichak KA, Hammond SL, Moreno JA, Afzali MF, Backos DS, Slayden RD, Safe S, Tjalkens RB. Compensatory expression of Nur77 and Nurr1 regulates NF-κB-dependent inflammatory signaling in astrocytes. Molecular Pharmacology. PMID 30111648 DOI: 10.1124/mol.118.112631  0.52
2018 Hedrick E, Mohankumar K, Safe S. TGFbeta-induced Lung Cancer Cell Migration is NR4A1-dependent. Molecular Cancer Research : McR. PMID 30072581 DOI: 10.1158/1541-7786.MCR-18-0366  0.88
2018 Afzali MF, Popichak KA, Burton LH, Klochak AL, Wilson WJ, Safe S, Tjalkens RB, Legare ME. A novel diindolylmethane analog, 1,1-bis(3'-indolyl)-1-(p-chlorophenyl) methane, inhibits the tumor necrosis factor-induced inflammatory response in primary murine synovial fibroblasts through a Nurr1-dependent mechanism. Molecular Immunology. 101: 46-54. PMID 29870816 DOI: 10.1016/j.molimm.2018.05.024  0.52
2018 Jin UH, Karki K, Kim SB, Safe S. Inhibition of pancreatic cancer Panc1 cell migration by omeprazole is dependent on aryl hydrocarbon receptor activation of JNK. Biochemical and Biophysical Research Communications. PMID 29758193 DOI: 10.1016/j.bbrc.2018.05.061  0.96
2018 Mohankumar K, Lee J, Wu CS, Sun Y, Safe S. Bis-Indole-Derived NR4A1 Ligands and Metformin Exhibit NR4A1-Dependent Glucose Metabolism and Uptake in C2C12 Cells. Endocrinology. 159: 1950-1963. PMID 29635345 DOI: 10.1210/en.2017-03049  0.88
2018 Hammond SL, Popichak KA, Li X, Hunt LG, Richman EH, Damale P, Chong E, Backos DS, Safe S, Tjalkens RB. The Nurr1 ligand,1,1-bis(3'-indolyl)-1-(p-chlorophenyl)methane, modulates glial reactivity and is neuroprotective in MPTP-induced parkinsonism. The Journal of Pharmacology and Experimental Therapeutics. PMID 29626009 DOI: 10.1124/jpet.117.246389  0.76
2018 Draz H, Goldberg AA, Tomlinson Guns ES, Fazli L, Safe S, Sanderson JT. Autophagy inhibition improves the chemotherapeutic efficacy of cruciferous vegetable-derived diindolymethane in a murine prostate cancer xenograft model. Investigational New Drugs. PMID 29607466 DOI: 10.1007/s10637-018-0595-8  0.52
2018 Jin UH, Park H, Li X, Davidson LA, Allred C, Patil B, Jayaprakasha G, Orr AA, Mao L, Chapkin RS, Jayaraman A, Tamamis P, Safe S. Structure-Dependent Modulation of Aryl Hydrocarbon Receptor-Mediated Activities by Flavones. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 29584932 DOI: 10.1093/toxsci/kfy075  0.96
2018 Safe S, Abbruzzese JL, Abdelrahim M, Hedrick E. Specificity Protein Transcription Factors and Cancer: Opportunities for Drug Development. Cancer Prevention Research (Philadelphia, Pa.). PMID 29545399 DOI: 10.1158/1940-6207.CAPR-17-0407  0.8
2018 Cheng Y, Imanirad P, Jutooru I, Hedrick E, Jin UH, Rodrigues Hoffman A, Leal de Araujo J, Morpurgo B, Golovko A, Safe S. Role of metastasis-associated lung adenocarcinoma transcript-1 (MALAT-1) in pancreatic cancer. Plos One. 13: e0192264. PMID 29389953 DOI: 10.1371/journal.pone.0192264  0.96
2017 Safe S, Naira V, Karki K. Metformin-induced anticancer activities: recent insights. Biological Chemistry. PMID 29272251 DOI: 10.1515/hsz-2017-0271  0.84
2017 Li Y, Wang F, Lu L, Zhu F, Huang S, Nomie K, Zhang L, Yang DT, Huang W, Kahl BS, Safe S, Wang M, Rui L. NR4A1 inhibition synergizes with ibrutinib in killing mantle cell lymphoma cells. Blood Cancer Journal. 7: 632. PMID 29167454 DOI: 10.1038/s41408-017-0005-z  0.68
2017 Draz H, Goldberg AA, Titorenko VI, Guns E, Safe SH, Sanderson JT. Diindolylmethane and its halogenated derivatives induce protective autophagy in human prostate cancer cells via induction of the oncogenic protein AEG-1 and activation of AMP-dependent kinase (AMPK). Cellular Signalling. PMID 28923415 DOI: 10.1016/j.cellsig.2017.09.006  0.52
2017 Jin UH, Cheng Y, Park H, Davidson LA, Callaway ES, Chapkin RS, Jayaraman A, Asante A, Allred C, Weaver EA, Safe S. Short Chain Fatty Acids Enhance Aryl Hydrocarbon (Ah) Responsiveness in Mouse Colonocytes and Caco-2 Human Colon Cancer Cells. Scientific Reports. 7: 10163. PMID 28860561 DOI: 10.1038/s41598-017-10824-x  0.96
2017 Hedrick E, Lee SO, Doddapaneni R, Singh M, Safe S. Correction for Hedrick et al., "NR4A1 Antagonists Inhibit β1-Integrin-Dependent Breast Cancer Cell Migration". Molecular and Cellular Biology. 37. PMID 28847971 DOI: 10.1128/MCB.00197-17  0.96
2017 Lee HS, Safe S, Lee SO. Inactivation of the orphan nuclear receptor NR4A1 contributes to apoptosis induction by fangchinoline in pancreatic cancer cells. Toxicology and Applied Pharmacology. PMID 28754437 DOI: 10.1016/j.taap.2017.07.017  0.96
2017 Kolluri SK, Jin UH, Safe S. Erratum to: Role of the aryl hydrocarbon receptor in carcinogenesis and potential as an anti-cancer drug target. Archives of Toxicology. PMID 28695231 DOI: 10.1007/s00204-017-2026-6  0.96
2017 Hedrick E, Safe S. TGFβ/NR4A1 Inducible Breast Cancer Cell Migration and Epithelial to Mesenchymal Transition is p38α (MAPK14) Dependent. Molecular and Cellular Biology. PMID 28674186 DOI: 10.1128/MCB.00306-17  0.8
2017 Karki K, Hedrick E, Kasiappan R, Jin UH, Safe S. Piperlongumine Induces Reactive Oxygen Species (ROS)-dependent Downregulation of Specificity Protein Transcription Factors. Cancer Prevention Research (Philadelphia, Pa.). PMID 28673967 DOI: 10.1158/1940-6207.CAPR-17-0053  0.96
2017 Kolluri SK, Jin UH, Safe S. Role of the aryl hydrocarbon receptor in carcinogenesis and potential as an anti-cancer drug target. Archives of Toxicology. PMID 28508231 DOI: 10.1007/s00204-017-1981-2  0.96
2017 Safe S, Cheng Y, Jin UH. The Aryl Hydrocarbon Receptor (AhR) as a Drug Target for Cancer Chemotherapy. Current Opinion in Toxicology. 2: 24-29. PMID 28459113 DOI: 10.1016/j.cotox.2017.01.012  0.96
2017 Hedrick E, Lee SO, Safe S. The Nuclear Orphan Receptor NR4A1 Regulates β1-Integrin Expression in Pancreatic and Colon Cancer Cells and Can Be Targeted by NR4A1 Antagonists. Molecular Carcinogenesis. PMID 28418095 DOI: 10.1002/mc.22662  0.96
2017 Taoka R, Jinesh GG, Xue W, Safe S, Kamat AM. CF3DODA-Me induces apoptosis, degrades Sp1, and blocks the transformation phase of the blebbishield emergency program. Apoptosis : An International Journal On Programmed Cell Death. PMID 28283889 DOI: 10.1007/s10495-017-1359-1  0.52
2017 Jin U, Cheng Y, Zhou B, Safe S. The Antineoplastic Activity of Bardoxolone Methyl and a Related Triterpenoid in Leukemia Cells Is Due to Reactive Oxygen Species-Dependent Suppression of cMyc. Molecular Pharmacology. PMID 28275049 DOI: 10.1124/mol.116.106245  0.8
2016 Kasiappan R, Jutooru I, Karki K, Hedrick E, Safe SH. Benzylisothiocyanate (BITC) Induces ROS-dependent Repression of STAT3 by Downregulation of Specificity Proteins in Pancreatic Cancer. The Journal of Biological Chemistry. PMID 27875298 DOI: 10.1074/jbc.M116.746339  0.84
2016 Lacey A, Rodrigues Hoffman A, Safe S. PAX3-FOXO1A expression in rhabdomyosarcoma is driven by the targetable nuclear receptor NR4A1. Cancer Research. PMID 27864345 DOI: 10.1158/0008-5472.CAN-16-1546  0.36
2016 Cheng Y, Jin UH, Davidson LA, Chapkin RS, Jayaraman A, Tamamis P, Orr A, Allred C, Denison MS, Soshilov A, Weaver E, Safe S. Microbial-Derived 1,4-Dihydroxy-2-naphthoic Acid and Related Compounds as Aryl Hydrocarbon Receptor Agonists/Antagonists: Structure-Activity Relationships and Receptor Modeling. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 27837168 DOI: 10.1093/toxsci/kfw230  0.96
2016 Hedrick E, Li X, Safe S. Penfluridol Represses Integrin Expression in Breast Cancer through Induction of Reactive Oxygen Species and Downregulation of Sp Transcription Factors. Molecular Cancer Therapeutics. PMID 27811009 DOI: 10.1158/1535-7163.MCT-16-0451  0.8
2016 Godugu C, Doddapaneni R, Safe SH, Singh M. Novel Diindolylmethane derivatives based NLC formulations to improve the oral Bioavailability and anticancer effects in Triple Negative Breast Cancer. European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V. PMID 27586082 DOI: 10.1016/j.ejpb.2016.08.006  0.56
2016 Boakye CH, Patel K, Patel AR, Faria HA, Zucolotto V, Safe S, Singh M. Lipid-based oral delivery systems for skin deposition of a potential chemopreventive DIM derivative: characterization and evaluation. Drug Delivery and Translational Research. PMID 27405772 DOI: 10.1007/s13346-016-0302-2  0.96
2016 Safe S, Kasiappan R. Natural Products as Mechanism-based Anticancer Agents: Sp Transcription Factors as Targets. Phytotherapy Research : Ptr. PMID 27384261 DOI: 10.1002/ptr.5669  0.56
2016 Moore RW, Fritz WA, Schneider AJ, Lin TM, Branam AM, Safe S, Peterson RE. 2,3,7,8-Tetrachlorodibenzo-p-dioxin has both pro-carcinogenic and anti-carcinogenic effects on neuroendocrine prostate carcinoma formation in TRAMP mice. Toxicology and Applied Pharmacology. PMID 27151233 DOI: 10.1016/j.taap.2016.04.018  0.96
2016 Lacey A, Hedrick E, Li X, Patel K, Doddapaneni R, Singh M, Safe S. Nuclear receptor 4A1 (NR4A1) as a drug target for treating rhabdomyosarcoma (RMS). Oncotarget. PMID 27144436 DOI: 10.18632/oncotarget.9112  0.8
2016 Takeuchi H, Taoka R, Mmeje CO, Jinesh GG, Safe S, Kamat AM. CDODA-Me decreases specificity protein transcription factors and induces apoptosis in bladder cancer cells through induction of reactive oxygen species. Urologic Oncology. PMID 27038699 DOI: 10.1016/j.urolonc.2016.02.025  0.52
2016 Goldberg AA, Draz H, Montes-Grajales D, Olivero-Verbél J, Safe SH, Sanderson JT. Erratum: 3,3'-Diindolylmethane (DIM) and its ring-substituted halogenated analogs (ring-DIMs) induce differential mechanisms of survival and death in androgen-dependent and-independent prostate cancer cells. Genes & Cancer. 7: 59. PMID 27014422  0.52
2016 Boakye CH, Patel K, Doddapaneni R, Bagde A, Chowdhury N, Safe S, Singh M. Ultra-flexible nanocarriers for enhanced topical delivery of a highly lipophilic antioxidative molecule for skin cancer chemoprevention. Colloids and Surfaces. B, Biointerfaces. 143: 156-167. PMID 27003466 DOI: 10.1016/j.colsurfb.2016.03.036  0.96
2016 Hedrick E, Cheng Y, Jin UH, Kim K, Safe S. Specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 are non-oncogene addiction genes in cancer cells. Oncotarget. PMID 26967243 DOI: 10.18632/oncotarget.7925  1
2016 Hedrick E, Lee SO, Doddapaneni R, Singh M, Safe S. NR4A1 Antagonists Inhibit β1-Integrin-Dependent Breast Cancer Cell Migration. Molecular and Cellular Biology. PMID 26929200 DOI: 10.1128/MCB.00912-15  0.96
2016 Ying W, Tseng A, Chang RC, Wang H, Lin YL, Kanameni S, Brehm T, Morin A, Jones B, Splawn T, Criscitiello M, Golding MC, Bazer FW, Safe S, Zhou B. miR-150 regulates obesity-associated insulin resistance by controlling B cell functions. Scientific Reports. 6: 20176. PMID 26833392 DOI: 10.1038/srep20176  0.96
2015 Li X, Pathi SS, Safe S. Sulindac sulfide inhibits colon cancer cell growth and downregulates specificity protein transcription factors. Bmc Cancer. 15: 974. PMID 26673922 DOI: 10.1186/s12885-015-1956-8  0.96
2015 Ying W, Tseng A, Chang RC, Morin A, Brehm T, Triff K, Nair V, Zhuang G, Song H, Kanameni S, Wang H, Golding MC, Bazer FW, Chapkin RS, Safe S, et al. MicroRNA-223 is a crucial mediator of PPARγ-regulated alternative macrophage activation. The Journal of Clinical Investigation. PMID 26436647 DOI: 10.1172/JCI81656  0.96
2015 Hammond SL, Safe S, Tjalkens RB. A novel synthetic activator of Nurr1 induces dopaminergic gene expression and protects against 6-hydroxydopamine neurotoxicity in vitro. Neuroscience Letters. 607: 83-9. PMID 26383113 DOI: 10.1016/j.neulet.2015.09.015  0.96
2015 Gandhy SU, Imanirad P, Jin UH, Nair V, Hedrick E, Cheng Y, Corton JC, Kim K, Safe S. Specificity protein (Sp) transcription factors and metformin regulate expression of the long non-coding RNA HULC. Oncotarget. PMID 26317792 DOI: 10.18632/oncotarget.4560  0.96
2015 Boakye CH, Shah PP, Doddapaneni R, Patel AR, Safe S, Singh M. Enhanced Percutaneous Delivery of 1,1-bis(3'-indolyl)-1-(p-chlorophenyl) Methane for Skin Cancer Chemoprevention. Journal of Biomedical Nanotechnology. 11: 1269-81. PMID 26307849 DOI: 10.1166/jbn.2015.2064  0.96
2015 Hedrick E, Lee SO, Doddapaneni R, Singh M, Safe S. Nuclear Receptor 4A1 (NR4A1) as a Drug Target for Breast Cancer Chemotherapy. Endocrine-Related Cancer. PMID 26229035 DOI: 10.1530/ERC-15-0063  0.96
2015 Riddell N, Jin UH, Safe S, Cheng Y, Chittim B, Konstantinov A, Parette R, Pena-Abaurrea M, Reiner EJ, Poirier D, Stefanac T, McAlees AJ, McCrindle R. Characterization and Biological Potency of Mono- to Tetra-Halogenated Carbazoles. Environmental Science & Technology. 49: 10658-66. PMID 26226543 DOI: 10.1021/acs.est.5b02751  0.96
2015 Hedrick E, Crose L, Linardic CM, Safe S. Histone Deacetylase Inhibitors Inhibit Rhabdomyosarcoma by Reactive Oxygen Species-Dependent Targeting of Specificity Protein Transcription Factors. Molecular Cancer Therapeutics. 14: 2143-53. PMID 26162688 DOI: 10.1158/1535-7163.MCT-15-0148  0.8
2015 Das Gupta S, Sae-Tan S, Wahler J, So JY, Bak MJ, Cheng LC, Lee MJ, Lin Y, Shih WJ, Shull JD, Safe S, Yang CS, Suh N. Dietary γ-Tocopherol Rich Mixture Inhibits Estrogen-Induced Mammary Tumorigenesis by Modulating Estrogen Metabolism, Antioxidant Response and PPARγ. Cancer Prevention Research (Philadelphia, Pa.). PMID 26130252 DOI: 10.1158/1940-6207.CAPR-15-0154  0.96
2015 Goldberg AA, Draz H, Montes-Grajales D, Olivero-Verbél J, Safe SH, Sanderson JT. 3,3'-Diindolylmethane (DIM) and its ring-substituted halogenated analogs (ring-DIMs) induce differential mechanisms of survival and death in androgen-dependent and -independent prostate cancer cells. Genes & Cancer. 6: 265-80. PMID 26124925  0.52
2015 Patel AR, Doddapaneni R, Andey T, Wilson H, Safe S, Singh M. Evaluation of self-emulsified DIM-14 in dogs for oral bioavailability and in Nu/nu mice bearing stem cell lung tumor models for anticancer activity. Journal of Controlled Release : Official Journal of the Controlled Release Society. 213: 18-26. PMID 26079185 DOI: 10.1016/j.jconrel.2015.06.014  0.56
2015 Hedrick E, Lee SO, Kim G, Abdelrahim M, Jin UH, Safe S, Abudayyeh A. Nuclear Receptor 4A1 (NR4A1) as a Drug Target for Renal Cell Adenocarcinoma. Plos One. 10: e0128308. PMID 26035713 DOI: 10.1371/journal.pone.0128308  0.96
2015 Fan YY, Davidson LA, Callaway ES, Wright GA, Safe S, Chapkin RS. A bioassay to measure energy metabolism in mouse colonic crypts, organoids, and sorted stem cells. American Journal of Physiology. Gastrointestinal and Liver Physiology. 309: G1-9. PMID 25977509 DOI: 10.1152/ajpgi.00052.2015  0.96
2015 Safe S, Jin UH, Morpurgo B, Abudayyeh A, Singh M, Tjalkens RB. Nuclear receptor 4A (NR4A) family - orphans no more. The Journal of Steroid Biochemistry and Molecular Biology. PMID 25917081 DOI: 10.1016/j.jsbmb.2015.04.016  0.96
2015 Cheng Y, Jutooru I, Chadalapaka G, Corton JC, Safe S. The long non-coding RNA HOTTIP enhances pancreatic cancer cell proliferation, survival and migration. Oncotarget. 6: 10840-52. PMID 25912306  0.8
2015 Cheng Y, Jin UH, Allred CD, Jayraman A, Chapkin RS, Safe S. Aryl Hydrocarbon Receptor Activity of Tryptophan Metabolites in Young Adult Mouse Colonocytes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 25873348 DOI: 10.1124/dmd.115.063677  0.96
2015 De Miranda BR, Popichak KA, Hammond SL, Jorgensen BA, Phillips AT, Safe S, Tjalkens RB. The Nurr1 Activator 1,1-Bis(3'-Indolyl)-1-(p-Chlorophenyl)Methane Blocks Inflammatory Gene Expression in BV-2 Microglial Cells by Inhibiting Nuclear Factor κB. Molecular Pharmacology. 87: 1021-34. PMID 25858541 DOI: 10.1124/mol.114.095398  0.96
2015 Jin UH, Kim SB, Safe S. Omeprazole Inhibits Pancreatic Cancer Cell Invasion through a Nongenomic Aryl Hydrocarbon Receptor Pathway. Chemical Research in Toxicology. 28: 907-18. PMID 25826687 DOI: 10.1021/tx5005198  0.96
2015 Patel AR, Godugu C, Wilson H, Safe S, Singh M. Evaluation of Spray BIO-Max DIM-P in Dogs for Oral Bioavailability and in Nu/nu Mice Bearing Orthotopic/Metastatic Lung Tumor Models for Anticancer Activity. Pharmaceutical Research. 32: 2292-300. PMID 25576245 DOI: 10.1007/s11095-015-1620-7  0.56
2015 De Miranda BR, Popichak KA, Hammond SL, Miller JA, Safe S, Tjalkens RB. Novel para-phenyl substituted diindolylmethanes protect against MPTP neurotoxicity and suppress glial activation in a mouse model of Parkinson's disease. Toxicological Sciences : An Official Journal of the Society of Toxicology. 143: 360-73. PMID 25406165 DOI: 10.1093/toxsci/kfu236  0.52
2015 Phillips TD, Richardson M, Cheng YS, He L, McDonald TJ, Cizmas LH, Safe SH, Donnelly KC, Wang F, Moorthy B, Zhou GD. Mechanistic relationships between hepatic genotoxicity and carcinogenicity in male B6C3F1 mice treated with polycyclic aromatic hydrocarbon mixtures. Archives of Toxicology. 89: 967-77. PMID 24888377 DOI: 10.1007/s00204-014-1285-8  0.96
2014 Yang WS, Chadalapaka G, Cho SG, Lee SO, Jin UH, Jutooru I, Choi K, Leung YK, Ho SM, Safe S, Kim K. The transcriptional repressor ZBTB4 regulates EZH2 through a MicroRNA-ZBTB4-specificity protein signaling axis. Neoplasia (New York, N.Y.). 16: 1059-69. PMID 25499219 DOI: 10.1016/j.neo.2014.09.011  1
2014 Nair V, Sreevalsan S, Basha R, Abdelrahim M, Abudayyeh A, Rodrigues Hoffman A, Safe S. Mechanism of metformin-dependent inhibition of mammalian target of rapamycin (mTOR) and Ras activity in pancreatic cancer: role of specificity protein (Sp) transcription factors. The Journal of Biological Chemistry. 289: 27692-701. PMID 25143389 DOI: 10.1074/jbc.M114.592576  0.96
2014 Lee SO, Li X, Hedrick E, Jin UH, Tjalkens RB, Backos DS, Li L, Zhang Y, Wu Q, Safe S. Diindolylmethane analogs bind NR4A1 and are NR4A1 antagonists in colon cancer cells. Molecular Endocrinology (Baltimore, Md.). 28: 1729-39. PMID 25099012 DOI: 10.1210/me.2014-1102  0.96
2014 Jin UH, Lee SO, Pfent C, Safe S. The aryl hydrocarbon receptor ligand omeprazole inhibits breast cancer cell invasion and metastasis. Bmc Cancer. 14: 498. PMID 25011475 DOI: 10.1186/1471-2407-14-498  0.96
2014 Ying W, Kanameni S, Chang CA, Nair V, Safe S, Bazer FW, Zhou B. Interferon tau alleviates obesity-induced adipose tissue inflammation and insulin resistance by regulating macrophage polarization. Plos One. 9: e98835. PMID 24905566 DOI: 10.1371/journal.pone.0098835  0.96
2014 Safe S, Imanirad P, Sreevalsan S, Nair V, Jutooru I. Transcription factor Sp1, also known as specificity protein 1 as a therapeutic target. Expert Opinion On Therapeutic Targets. 18: 759-69. PMID 24793594 DOI: 10.1517/14728222.2014.914173  0.6
2014 Zhang Z, Kim K, Li X, Moreno M, Sharp T, Goodheart MJ, Safe S, Dupuy AJ, Amendt BA. MicroRNA-26b represses colon cancer cell proliferation by inhibiting lymphoid enhancer factor 1 expression. Molecular Cancer Therapeutics. 13: 1942-51. PMID 24785257 DOI: 10.1158/1535-7163.MCT-13-1000  0.96
2014 Jutooru I, Guthrie AS, Chadalapaka G, Pathi S, Kim K, Burghardt R, Jin UH, Safe S. Mechanism of action of phenethylisothiocyanate and other reactive oxygen species-inducing anticancer agents. Molecular and Cellular Biology. 34: 2382-95. PMID 24732804 DOI: 10.1128/MCB.01602-13  0.96
2014 Jin UH, Lee SO, Sridharan G, Lee K, Davidson LA, Jayaraman A, Chapkin RS, Alaniz R, Safe S. Microbiome-derived tryptophan metabolites and their aryl hydrocarbon receptor-dependent agonist and antagonist activities. Molecular Pharmacology. 85: 777-88. PMID 24563545 DOI: 10.1124/mol.113.091165  0.96
2014 Lee SO, Jin UH, Kang JH, Kim SB, Guthrie AS, Sreevalsan S, Lee JS, Safe S. The orphan nuclear receptor NR4A1 (Nur77) regulates oxidative and endoplasmic reticulum stress in pancreatic cancer cells. Molecular Cancer Research : McR. 12: 527-38. PMID 24515801 DOI: 10.1158/1541-7786.MCR-13-0567  0.96
2014 Patel AR, Chougule MB, Lim E, Francis KP, Safe S, Singh M. Theranostic tumor homing nanocarriers for the treatment of lung cancer. Nanomedicine : Nanotechnology, Biology, and Medicine. 10: 1053-63. PMID 24355163 DOI: 10.1016/j.nano.2013.12.002  0.96
2014 Safe S, Jin UH, Hedrick E, Reeder A, Lee SO. Minireview: role of orphan nuclear receptors in cancer and potential as drug targets. Molecular Endocrinology (Baltimore, Md.). 28: 157-72. PMID 24295738 DOI: 10.1210/me.2013-1291  0.96
2014 Pathi S, Li X, Safe S. Tolfenamic acid inhibits colon cancer cell and tumor growth and induces degradation of specificity protein (Sp) transcription factors. Molecular Carcinogenesis. 53: E53-61. PMID 23670891 DOI: 10.1002/mc.22010  0.96
2013 Sreevalsan S, Safe S. REACTIVE OXYGEN SPECIES AND COLORECTAL CANCER. Current Colorectal Cancer Reports. 9: 350-357. PMID 25584043 DOI: 10.1007/s11888-013-0190-5  0.52
2013 Sreevalsan S, Safe S. The cannabinoid WIN 55,212-2 decreases specificity protein transcription factors and the oncogenic cap protein eIF4E in colon cancer cells. Molecular Cancer Therapeutics. 12: 2483-93. PMID 24030632 DOI: 10.1158/1535-7163.MCT-13-0486  0.52
2013 Boakye CH, Doddapaneni R, Shah PP, Patel AR, Godugu C, Safe S, Katiyar SK, Singh M. Chemoprevention of skin cancer with 1,1-Bis (3'-indolyl)-1-(aromatic) methane analog through induction of the orphan nuclear receptor, NR4A2 (Nurr1). Plos One. 8: e69519. PMID 23950896 DOI: 10.1371/journal.pone.0069519  0.96
2013 Andey T, Patel A, Jackson T, Safe S, Singh M. 1,1-Bis (3'-indolyl)-1-(p-substitutedphenyl)methane compounds inhibit lung cancer cell and tumor growth in a metastasis model. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 50: 227-41. PMID 23892137 DOI: 10.1016/j.ejps.2013.07.007  0.56
2013 Ying W, Cheruku PS, Bazer FW, Safe SH, Zhou B. Investigation of macrophage polarization using bone marrow derived macrophages. Journal of Visualized Experiments : Jove. PMID 23851980 DOI: 10.3791/50323  0.76
2013 Nair V, Pathi S, Jutooru I, Sreevalsan S, Basha R, Abdelrahim M, Samudio I, Safe S. Metformin inhibits pancreatic cancer cell and tumor growth and downregulates Sp transcription factors. Carcinogenesis. 34: 2870-9. PMID 23803693 DOI: 10.1093/carcin/bgt231  0.96
2013 Safe S, Lee SO, Jin UH. Role of the aryl hydrocarbon receptor in carcinogenesis and potential as a drug target. Toxicological Sciences : An Official Journal of the Society of Toxicology. 135: 1-16. PMID 23771949 DOI: 10.1093/toxsci/kft128  0.96
2013 Bousquet M, Zhuang G, Meng C, Ying W, Cheruku PS, Shie AT, Wang S, Ge G, Wong P, Wang G, Safe S, Zhou B. miR-150 blocks MLL-AF9-associated leukemia through oncogene repression. Molecular Cancer Research : McR. 11: 912-22. PMID 23604034 DOI: 10.1158/1541-7786.MCR-13-0002-T  0.76
2013 Del Follo-Martinez A, Banerjee N, Li X, Safe S, Mertens-Talcott S. Resveratrol and quercetin in combination have anticancer activity in colon cancer cells and repress oncogenic microRNA-27a. Nutrition and Cancer. 65: 494-504. PMID 23530649 DOI: 10.1080/01635581.2012.725194  0.76
2013 van den Berg M, Denison MS, Birnbaum LS, Devito MJ, Fiedler H, Falandysz J, Rose M, Schrenk D, Safe S, Tohyama C, Tritscher A, Tysklind M, Peterson RE. Polybrominated dibenzo-p-dioxins, dibenzofurans, and biphenyls: inclusion in the toxicity equivalency factor concept for dioxin-like compounds. Toxicological Sciences : An Official Journal of the Society of Toxicology. 133: 197-208. PMID 23492812 DOI: 10.1093/toxsci/kft070  0.96
2013 Noratto GD, Jutooru I, Safe S, Angel-Morales G, Mertens-Talcott SU. The drug resistance suppression induced by curcuminoids in colon cancer SW-480 cells is mediated by reactive oxygen species-induced disruption of the microRNA-27a-ZBTB10-Sp axis. Molecular Nutrition & Food Research. 57: 1638-48. PMID 23471840 DOI: 10.1002/mnfr.201200609  0.6
2013 De Miranda BR, Miller JA, Hansen RJ, Lunghofer PJ, Safe S, Gustafson DL, Colagiovanni D, Tjalkens RB. Neuroprotective efficacy and pharmacokinetic behavior of novel anti-inflammatory para-phenyl substituted diindolylmethanes in a mouse model of Parkinson's disease. The Journal of Pharmacology and Experimental Therapeutics. 345: 125-38. PMID 23318470 DOI: 10.1124/jpet.112.201558  0.52
2013 Shin JA, Jung JY, Ryu MH, Safe S, Cho SD. Mithramycin A inhibits myeloid cell leukemia-1 to induce apoptosis in oral squamous cell carcinomas and tumor xenograft through activation of Bax and oligomerization. Molecular Pharmacology. 83: 33-41. PMID 23019217 DOI: 10.1124/mol.112.081364  0.76
2013 Chadalapaka G, Jutooru I, Sreevalsan S, Pathi S, Kim K, Chen C, Crose L, Linardic C, Safe S. Inhibition of rhabdomyosarcoma cell and tumor growth by targeting specificity protein (Sp) transcription factors. International Journal of Cancer. 132: 795-806. PMID 22815231 DOI: 10.1002/ijc.27730  0.96
2013 Kim K, Jutooru I, Chadalapaka G, Johnson G, Frank J, Burghardt R, Kim S, Safe S. HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer. Oncogene. 32: 1616-25. PMID 22614017 DOI: 10.1038/onc.2012.193  1
2013 Mertens-Talcott SU, Noratto GD, Li X, Angel-Morales G, Bertoldi MC, Safe S. Betulinic acid decreases ER-negative breast cancer cell growth in vitro and in vivo: role of Sp transcription factors and microRNA-27a:ZBTB10. Molecular Carcinogenesis. 52: 591-602. PMID 22407812 DOI: 10.1002/mc.21893  0.76
2012 Gandhy SU, Kim K, Larsen L, Rosengren RJ, Safe S. Curcumin and synthetic analogs induce reactive oxygen species and decreases specificity protein (Sp) transcription factors by targeting microRNAs. Bmc Cancer. 12: 564. PMID 23194063 DOI: 10.1186/1471-2407-12-564  1
2012 Pathi S, Jutooru I, Chadalapaka G, Nair V, Lee SO, Safe S. Aspirin inhibits colon cancer cell and tumor growth and downregulates specificity protein (Sp) transcription factors. Plos One. 7: e48208. PMID 23110215 DOI: 10.1371/journal.pone.0048208  0.96
2012 Banerjee N, Talcott S, Safe S, Mertens-Talcott SU. Cytotoxicity of pomegranate polyphenolics in breast cancer cells in vitro and vivo: potential role of miRNA-27a and miRNA-155 in cell survival and inflammation. Breast Cancer Research and Treatment. 136: 21-34. PMID 22941571 DOI: 10.1007/s10549-012-2224-0  0.48
2012 Jin UH, Lee SO, Safe S. Aryl hydrocarbon receptor (AHR)-active pharmaceuticals are selective AHR modulators in MDA-MB-468 and BT474 breast cancer cells. The Journal of Pharmacology and Experimental Therapeutics. 343: 333-41. PMID 22879383 DOI: 10.1124/jpet.112.195339  0.96
2012 Kim K, Chadalapaka G, Pathi SS, Jin UH, Lee JS, Park YY, Cho SG, Chintharlapalli S, Safe S. Induction of the transcriptional repressor ZBTB4 in prostate cancer cells by drug-induced targeting of microRNA-17-92/106b-25 clusters. Molecular Cancer Therapeutics. 11: 1852-62. PMID 22752225 DOI: 10.1158/1535-7163.MCT-12-0181  0.96
2012 Safe SH, Prather PL, Brents LK, Chadalapaka G, Jutooru I. Unifying mechanisms of action of the anticancer activities of triterpenoids and synthetic analogs. Anti-Cancer Agents in Medicinal Chemistry. 12: 1211-20. PMID 22583404  0.68
2012 Zhuang G, Meng C, Guo X, Cheruku PS, Shi L, Xu H, Li H, Wang G, Evans AR, Safe S, Wu C, Zhou B. A novel regulator of macrophage activation: miR-223 in obesity-associated adipose tissue inflammation. Circulation. 125: 2892-903. PMID 22580331 DOI: 10.1161/CIRCULATIONAHA.111.087817  0.76
2012 Liu X, Jutooru I, Lei P, Kim K, Lee SO, Brents LK, Prather PL, Safe S. Betulinic acid targets YY1 and ErbB2 through cannabinoid receptor-dependent disruption of microRNA-27a:ZBTB10 in breast cancer. Molecular Cancer Therapeutics. 11: 1421-31. PMID 22553354 DOI: 10.1158/1535-7163.MCT-12-0026  1
2012 Sankpal UT, Abdelrahim M, Connelly SF, Lee CM, Madero-Visbal R, Colon J, Smith J, Safe S, Maliakal P, Basha R. Small molecule tolfenamic acid inhibits PC-3 cell proliferation and invasion in vitro, and tumor growth in orthotopic mouse model for prostate cancer. The Prostate. 72: 1648-58. PMID 22473873 DOI: 10.1002/pros.22518  0.56
2012 Barchowsky A, Buckley LA, Carlson GP, Fitsanakis VA, Ford SM, Genter MB, Germolec DR, Leavens TL, Lehman-McKeeman LD, Safe SH, Sulentic CE, Eidemiller BJ. The Toxicology Education Summit: building the future of toxicology through education. Toxicological Sciences : An Official Journal of the Society of Toxicology. 127: 331-8. PMID 22461448 DOI: 10.1093/toxsci/kfs111  0.96
2012 Li X, Lee SO, Safe S. Structure-dependent activation of NR4A2 (Nurr1) by 1,1-bis(3'-indolyl)-1-(aromatic)methane analogs in pancreatic cancer cells. Biochemical Pharmacology. 83: 1445-55. PMID 22405837 DOI: 10.1016/j.bcp.2012.02.021  0.96
2012 Patel AR, Spencer SD, Chougule MB, Safe S, Singh M. Pharmacokinetic evaluation and in vitro-in vivo correlation (IVIVC) of novel methylene-substituted 3,3' diindolylmethane (DIM). European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 46: 8-16. PMID 22342559 DOI: 10.1016/j.ejps.2012.01.012  0.96
2012 Chadalapaka G, Jutooru I, Safe S. Celastrol decreases specificity proteins (Sp) and fibroblast growth factor receptor-3 (FGFR3) in bladder cancer cells. Carcinogenesis. 33: 886-94. PMID 22334592 DOI: 10.1093/carcin/bgs102  0.68
2012 Park YY, Kim K, Kim SB, Hennessy BT, Kim SM, Park ES, Lim JY, Li J, Lu Y, Gonzalez-Angulo AM, Jeong W, Mills GB, Safe S, Lee JS. Reconstruction of nuclear receptor network reveals that NR2E3 is a novel upstream regulator of ESR1 in breast cancer. Embo Molecular Medicine. 4: 52-67. PMID 22174013 DOI: 10.1002/emmm.201100187  1
2012 Lee SO, Andey T, Jin UH, Kim K, Singh M, Sachdeva M, Safe S. The nuclear receptor TR3 regulates mTORC1 signaling in lung cancer cells expressing wild-type p53. Oncogene. 31: 3265-76. PMID 22081070 DOI: 10.1038/onc.2011.504  1
2012 Zhang S, Kim K, Jin UH, Pfent C, Cao H, Amendt B, Liu X, Wilson-Robles H, Safe S. Aryl hydrocarbon receptor agonists induce microRNA-335 expression and inhibit lung metastasis of estrogen receptor negative breast cancer cells. Molecular Cancer Therapeutics. 11: 108-18. PMID 22034498 DOI: 10.1158/1535-7163.MCT-11-0548  1
2012 Li Z, Chadalapaka G, Ramesh A, Khoshbouei H, Maguire M, Safe S, Rhoades RE, Clark R, Jules G, McCallister M, Aschner M, Hood DB. PAH particles perturb prenatal processes and phenotypes: protection from deficits in object discrimination afforded by dampening of brain oxidoreductase following in utero exposure to inhaled benzo(a)pyrene. Toxicological Sciences : An Official Journal of the Society of Toxicology. 125: 233-47. PMID 21987461 DOI: 10.1093/toxsci/kfr261  0.96
2012 Kim K, Chadalapaka G, Lee SO, Yamada D, Sastre-Garau X, Defossez PA, Park YY, Lee JS, Safe S. Identification of oncogenic microRNA-17-92/ZBTB4/specificity protein axis in breast cancer. Oncogene. 31: 1034-44. PMID 21765466 DOI: 10.1038/onc.2011.296  1
2012 Maliakal P, Abdelrahim M, Sankpal UT, Maliakal C, Baker CH, Safe S, Herrera LJ, Abudayyeh A, Kaja S, Basha R. Chemopreventive effects of tolfenamic acid against esophageal tumorigenesis in rats. Investigational New Drugs. 30: 853-61. PMID 21197621 DOI: 10.1007/s10637-010-9622-0  0.56
2011 Sreevalsan S, Joseph S, Jutooru I, Chadalapaka G, Safe SH. Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent. Anticancer Research. 31: 3799-807. PMID 22110202  0.68
2011 Pathi SS, Lei P, Sreevalsan S, Chadalapaka G, Jutooru I, Safe S. Pharmacologic doses of ascorbic acid repress specificity protein (Sp) transcription factors and Sp-regulated genes in colon cancer cells. Nutrition and Cancer. 63: 1133-42. PMID 21919647 DOI: 10.1080/01635581.2011.605984  0.96
2011 Chintharlapalli S, Papineni S, Lei P, Pathi S, Safe S. Betulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and -independent downregulation of specificity proteins (Sp) transcription factors. Bmc Cancer. 11: 371. PMID 21864401 DOI: 10.1186/1471-2407-11-371  0.96
2011 Shin JA, Shim JH, Choi ES, Leem DH, Kwon KH, Lee SO, Safe S, Cho NP, Cho SD. Chemopreventive effects of synthetic C-substituted diindolylmethanes originating from cruciferous vegetables in human oral cancer cells. European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (Ecp). 20: 417-25. PMID 21597379 DOI: 10.1097/CEJ.0b013e32834473c3  0.96
2011 Barhoumi R, Mouneimne Y, Ramos E, Morisseau C, Hammock BD, Safe S, Parrish AR, Burghardt RC. Multiphoton spectral analysis of benzo[a]pyrene uptake and metabolism in a rat liver cell line. Toxicology and Applied Pharmacology. 253: 45-56. PMID 21420996 DOI: 10.1016/j.taap.2011.03.009  0.96
2011 Yoon K, Lee SO, Cho SD, Kim K, Khan S, Safe S. Activation of nuclear TR3 (NR4A1) by a diindolylmethane analog induces apoptosis and proapoptotic genes in pancreatic cancer cells and tumors. Carcinogenesis. 32: 836-42. PMID 21362629 DOI: 10.1093/carcin/bgr040  1
2011 Abdelbaqi K, Lack N, Guns ET, Kotha L, Safe S, Sanderson JT. Antiandrogenic and growth inhibitory effects of ring-substituted analogs of 3,3'-diindolylmethane (ring-DIMs) in hormone-responsive LNCaP human prostate cancer cells. The Prostate. 71: 1401-12. PMID 21321979 DOI: 10.1002/pros.21356  0.52
2011 Chintharlapalli S, Papineni S, Lee SO, Lei P, Jin UH, Sherman SI, Santarpia L, Safe S. Inhibition of pituitary tumor-transforming gene-1 in thyroid cancer cells by drugs that decrease specificity proteins. Molecular Carcinogenesis. 50: 655-67. PMID 21268135 DOI: 10.1002/mc.20738  1
2011 Lee SO, Li X, Khan S, Safe S. Targeting NR4A1 (TR3) in cancer cells and tumors. Expert Opinion On Therapeutic Targets. 15: 195-206. PMID 21204731 DOI: 10.1517/14728222.2011.547481  0.96
2011 Basha R, Baker CH, Sankpal UT, Ahmad S, Safe S, Abbruzzese JL, Abdelrahim M. Therapeutic applications of NSAIDS in cancer: special emphasis on tolfenamic acid. Frontiers in Bioscience (Scholar Edition). 3: 797-805. PMID 21196413  0.56
2011 Kim K, Burghardt R, Barhoumi R, Lee SO, Liu X, Safe S. MDM2 regulates estrogen receptor α and estrogen responsiveness in breast cancer cells. Journal of Molecular Endocrinology. 46: 67-79. PMID 21169420 DOI: 10.1677/JME-10-0110  1
2011 Pathi SS, Jutooru I, Chadalapaka G, Sreevalsan S, Anand S, Thatcher GR, Safe S. GT-094, a NO-NSAID, inhibits colon cancer cell growth by activation of a reactive oxygen species-microRNA-27a: ZBTB10-specificity protein pathway. Molecular Cancer Research : McR. 9: 195-202. PMID 21156786 DOI: 10.1158/1541-7786.MCR-10-0363  0.96
2011 Colon J, Basha MR, Madero-Visbal R, Konduri S, Baker CH, Herrera LJ, Safe S, Sheikh-Hamad D, Abudayyeh A, Alvarado B, Abdelrahim M. Tolfenamic acid decreases c-Met expression through Sp proteins degradation and inhibits lung cancer cells growth and tumor formation in orthotopic mice. Investigational New Drugs. 29: 41-51. PMID 19851711 DOI: 10.1007/s10637-009-9331-8  0.56
2010 Vanderlaag K, Su Y, Frankel AE, Burghardt RC, Barhoumi R, Chadalapaka G, Jutooru I, Safe S. 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induce autophagic cell death in estrogen receptor negative breast cancer. Bmc Cancer. 10: 669. PMID 21129193 DOI: 10.1186/1471-2407-10-669  0.96
2010 Ichite N, Chougule M, Patel AR, Jackson T, Safe S, Singh M. Inhalation delivery of a novel diindolylmethane derivative for the treatment of lung cancer. Molecular Cancer Therapeutics. 9: 3003-14. PMID 20978159 DOI: 10.1158/1535-7163.MCT-09-1104  0.56
2010 Lee SO, Abdelrahim M, Yoon K, Chintharlapalli S, Papineni S, Kim K, Wang H, Safe S. Inactivation of the orphan nuclear receptor TR3/Nur77 inhibits pancreatic cancer cell and tumor growth. Cancer Research. 70: 6824-36. PMID 20660371 DOI: 10.1158/0008-5472.CAN-10-1992  1
2010 Roberts RA, Smith RA, Safe S, Szabo C, Tjalkens RB, Robertson FM. Toxicological and pathophysiological roles of reactive oxygen and nitrogen species. Toxicology. 276: 85-94. PMID 20643181 DOI: 10.1016/j.tox.2010.07.009  0.96
2010 Jutooru I, Chadalapaka G, Lei P, Safe S. Inhibition of NFkappaB and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein down-regulation. The Journal of Biological Chemistry. 285: 25332-44. PMID 20538607 DOI: 10.1074/jbc.M109.095240  0.8
2010 Tsao T, Kornblau S, Safe S, Watt JC, Ruvolo V, Chen W, Qiu Y, Coombes KR, Ju Z, Abdelrahim M, Schober W, Ling X, Kardassis D, Meyer C, Schimmer A, et al. Role of peroxisome proliferator-activated receptor-gamma and its coactivator DRIP205 in cellular responses to CDDO (RTA-401) in acute myelogenous leukemia. Cancer Research. 70: 4949-60. PMID 20501850 DOI: 10.1158/0008-5472.CAN-09-1962  0.96
2010 Jutooru I, Chadalapaka G, Abdelrahim M, Basha MR, Samudio I, Konopleva M, Andreeff M, Safe S. Methyl 2-cyano-3,12-dioxooleana-1,9-dien-28-oate decreases specificity protein transcription factors and inhibits pancreatic tumor growth: role of microRNA-27a. Molecular Pharmacology. 78: 226-36. PMID 20488920 DOI: 10.1124/mol.110.064451  0.72
2010 Jutooru I, Chadalapaka G, Sreevalsan S, Lei P, Barhoumi R, Burghardt R, Safe S. Arsenic trioxide downregulates specificity protein (Sp) transcription factors and inhibits bladder cancer cell and tumor growth. Experimental Cell Research. 316: 2174-88. PMID 20435036 DOI: 10.1016/j.yexcr.2010.04.027  0.8
2010 Chadalapaka G, Jutooru I, Burghardt R, Safe S. Drugs that target specificity proteins downregulate epidermal growth factor receptor in bladder cancer cells. Molecular Cancer Research : McR. 8: 739-50. PMID 20407012 DOI: 10.1158/1541-7786.MCR-09-0493  0.76
2010 Li X, Mertens-Talcott SU, Zhang S, Kim K, Ball J, Safe S. MicroRNA-27a Indirectly Regulates Estrogen Receptor {alpha} Expression and Hormone Responsiveness in MCF-7 Breast Cancer Cells. Endocrinology. 151: 2462-73. PMID 20382698 DOI: 10.1210/en.2009-1150  1
2010 Bredfeldt TG, Greathouse KL, Safe SH, Hung MC, Bedford MT, Walker CL. Xenoestrogen-induced regulation of EZH2 and histone methylation via estrogen receptor signaling to PI3K/AKT. Molecular Endocrinology (Baltimore, Md.). 24: 993-1006. PMID 20351197 DOI: 10.1210/me.2009-0438  0.96
2010 Cho SD, Lee SO, Chintharlapalli S, Abdelrahim M, Khan S, Yoon K, Kamat AM, Safe S. Activation of nerve growth factor-induced B alpha by methylene-substituted diindolylmethanes in bladder cancer cells induces apoptosis and inhibits tumor growth. Molecular Pharmacology. 77: 396-404. PMID 20023005 DOI: 10.1124/mol.109.061143  1
2010 Choi KH, Kim HK, Kim JH, Choi ES, Shin JA, Lee SO, Chintharlapalli S, Safe S, Abdelrahim M, Kong G, Choi HS, Jung JY, Cho HT, Cho NP, Cho SD. The p38 MAPK pathway is critical for 5,5'-dibromodiindolylmethane-induced apoptosis to prevent oral squamous carcinoma cells. European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (Ecp). 19: 153-9. PMID 19949342 DOI: 10.1097/CEJ.0b013e328333d088  1
2010 Guo J, Chintharlapalli S, Lee SO, Cho SD, Lei P, Papineni S, Safe S. Peroxisome proliferator-activated receptor gamma-dependent activity of indole ring-substituted 1,1-bis(3'-indolyl)-1-(p-biphenyl)methanes in cancer cells. Cancer Chemotherapy and Pharmacology. 66: 141-50. PMID 19823826 DOI: 10.1007/s00280-009-1144-0  1
2009 Sreevalsan S, Jutooru I, Chadalapaka G, Walker M, Safe S. 1,1-Bis(3'-indolyl)-1-(p-bromophenyl)methane and related compounds repress survivin and decrease gamma-radiation-induced survivin in colon and pancreatic cancer cells. International Journal of Oncology. 35: 1191-9. PMID 19787275  0.68
2009 Lee SO, Chintharlapalli S, Liu S, Papineni S, Cho SD, Yoon K, Safe S. p21 expression is induced by activation of nuclear nerve growth factor-induced Balpha (Nur77) in pancreatic cancer cells. Molecular Cancer Research : McR. 7: 1169-78. PMID 19584258 DOI: 10.1158/1541-7786.MCR-08-0473  1
2009 Chintharlapalli S, Papineni S, Abdelrahim M, Abudayyeh A, Jutooru I, Chadalapaka G, Wu F, Mertens-Talcott S, Vanderlaag K, Cho SD, Smith R, Safe S. Oncogenic microRNA-27a is a target for anticancer agent methyl 2-cyano-3,11-dioxo-18beta-olean-1,12-dien-30-oate in colon cancer cells. International Journal of Cancer. 125: 1965-74. PMID 19582879 DOI: 10.1002/ijc.24530  1
2009 Zhang S, Lei P, Liu X, Li X, Walker K, Kotha L, Rowlands C, Safe S. The aryl hydrocarbon receptor as a target for estrogen receptor-negative breast cancer chemotherapy. Endocrine-Related Cancer. 16: 835-44. PMID 19447902 DOI: 10.1677/ERC-09-0054  0.8
2009 Liu X, Abdelrahim M, Abudayyeh A, Lei P, Safe S. The nonsteroidal anti-inflammatory drug tolfenamic acid inhibits BT474 and SKBR3 breast cancer cell and tumor growth by repressing erbB2 expression. Molecular Cancer Therapeutics. 8: 1207-17. PMID 19435870 DOI: 10.1158/1535-7163.MCT-08-1097  0.8
2009 Papineni S, Chintharlapalli S, Abdelrahim M, Lee SO, Burghardt R, Abudayyeh A, Baker C, Herrera L, Safe S. Tolfenamic acid inhibits esophageal cancer through repression of specificity proteins and c-Met. Carcinogenesis. 30: 1193-201. PMID 19406933 DOI: 10.1093/carcin/bgp092  1
2009 Konduri S, Colon J, Baker CH, Safe S, Abbruzzese JL, Abudayyeh A, Basha MR, Abdelrahim M. Tolfenamic acid enhances pancreatic cancer cell and tumor response to radiation therapy by inhibiting survivin protein expression. Molecular Cancer Therapeutics. 8: 533-42. PMID 19258429 DOI: 10.1158/1535-7163.MCT-08-0405  0.56
2009 Barhoumi R, Catania JM, Parrish AR, Awooda I, Tiffany-Castiglioni E, Safe S, Burghardt RC. Multiphoton spectral analysis of benzo[a]pyrene uptake and metabolism in breast epithelial cell lines. The Journal of Toxicological Sciences. 34: 13-25. PMID 19182432 DOI: JST.JSTAGE/jts/34.13  0.96
2009 Fritz WA, Lin TM, Safe S, Moore RW, Peterson RE. The selective aryl hydrocarbon receptor modulator 6-methyl-1,3,8-trichlorodibenzofuran inhibits prostate tumor metastasis in TRAMP mice. Biochemical Pharmacology. 77: 1151-60. PMID 19166822 DOI: 10.1016/j.bcp.2008.12.015  0.96
2009 Ichite N, Chougule MB, Jackson T, Fulzele SV, Safe S, Singh M. Enhancement of docetaxel anticancer activity by a novel diindolylmethane compound in human non-small cell lung cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 543-52. PMID 19147759 DOI: 10.1158/1078-0432.CCR-08-1558  0.56
2009 Jutooru I, Chadalapaka G, Chintharlapalli S, Papineni S, Safe S. Induction of apoptosis and nonsteroidal anti-inflammatory drug-activated gene 1 in pancreatic cancer cells by a glycyrrhetinic acid derivative. Molecular Carcinogenesis. 48: 692-702. PMID 19125423 DOI: 10.1002/mc.20518  1
2009 Wu F, Ivanov I, Xu R, Safe S. Role of SP transcription factors in hormone-dependent modulation of genes in MCF-7 breast cancer cells: microarray and RNA interference studies. Journal of Molecular Endocrinology. 42: 19-33. PMID 18952783 DOI: 10.1677/JME-08-0088  0.52
2009 Carbone DL, Popichak KA, Moreno JA, Safe S, Tjalkens RB. Suppression of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced nitric-oxide synthase 2 expression in astrocytes by a novel diindolylmethane analog protects striatal neurons against apoptosis. Molecular Pharmacology. 75: 35-43. PMID 18840677 DOI: 10.1124/mol.108.050781  0.52
2008 Inamoto T, Papineni S, Chintharlapalli S, Cho SD, Safe S, Kamat AM. 1,1-Bis(3'-indolyl)-1-(p-chlorophenyl)methane activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth. Molecular Cancer Therapeutics. 7: 3825-33. PMID 19074857 DOI: 10.1158/1535-7163.MCT-08-0730  1
2008 Lee SH, Bahn JH, Choi CK, Whitlock NC, English AE, Safe S, Baek SJ. ESE-1/EGR-1 pathway plays a role in tolfenamic acid-induced apoptosis in colorectal cancer cells. Molecular Cancer Therapeutics. 7: 3739-50. PMID 19074849 DOI: 10.1158/1535-7163.MCT-08-0548  0.8
2008 Lei P, Abdelrahim M, Cho SD, Liu X, Liu X, Safe S. Structure-dependent activation of endoplasmic reticulum stress-mediated apoptosis in pancreatic cancer by 1,1-bis(3'-indoly)-1-(p-substituted phenyl)methanes. Molecular Cancer Therapeutics. 7: 3363-72. PMID 18852139 DOI: 10.1158/1535-7163.MCT-08-0439  0.8
2008 Safe S, Kim K, Kim K. Non-classical genomic estrogen receptor (ER)/specificity protein and ER/activating protein-1 signaling pathways. Journal of Molecular Endocrinology. 41: 263-75. PMID 18772268 DOI: 10.1677/JME-08-0103  1
2008 Cho SD, Chintharlapalli S, Abdelrahim M, Papineni S, Liu S, Guo J, Lei P, Abudayyeh A, Safe S. 5,5'-Dibromo-bis(3'-indolyl)methane induces Kruppel-like factor 4 and p21 in colon cancer cells. Molecular Cancer Therapeutics. 7: 2109-20. PMID 18645021 DOI: 10.1158/1535-7163.MCT-07-2311  1
2008 Wu F, Xu R, Kim K, Martin J, Safe S. In vivo profiling of estrogen receptor/specificity protein-dependent transactivation. Endocrinology. 149: 5696-705. PMID 18635651 DOI: 10.1210/en.2008-0720  1
2008 Chadalapaka G, Jutooru I, Chintharlapalli S, Papineni S, Smith R, Li X, Safe S. Curcumin decreases specificity protein expression in bladder cancer cells. Cancer Research. 68: 5345-54. PMID 18593936 DOI: 10.1158/0008-5472.CAN-07-6805  1
2008 Safe S, Papineni S, Chintharlapalli S. Cancer chemotherapy with indole-3-carbinol, bis(3'-indolyl)methane and synthetic analogs. Cancer Letters. 269: 326-38. PMID 18501502 DOI: 10.1016/j.canlet.2008.04.021  1
2008 Lei P, Abdelrahim M, Cho SD, Liu S, Chintharlapalli S, Safe S. 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit colon cancer cell and tumor growth through activation of c-jun N-terminal kinase. Carcinogenesis. 29: 1139-47. PMID 18460448 DOI: 10.1093/carcin/bgn103  1
2008 Wu F, Khan S, Wu Q, Barhoumi R, Burghardt R, Safe S. Ligand structure-dependent activation of estrogen receptor alpha/Sp by estrogens and xenoestrogens. The Journal of Steroid Biochemistry and Molecular Biology. 110: 104-15. PMID 18400491 DOI: 10.1016/j.jsbmb.2008.02.008  0.76
2008 Chadalapaka G, Jutooru I, McAlees A, Stefanac T, Safe S. Structure-dependent inhibition of bladder and pancreatic cancer cell growth by 2-substituted glycyrrhetinic and ursolic acid derivatives. Bioorganic & Medicinal Chemistry Letters. 18: 2633-9. PMID 18359628 DOI: 10.1016/j.bmcl.2008.03.031  0.68
2008 Hong J, Samudio I, Chintharlapalli S, Safe S. 1,1-bis(3'-indolyl)-1-(p-substituted phenyl)methanes decrease mitochondrial membrane potential and induce apoptosis in endometrial and other cancer cell lines. Molecular Carcinogenesis. 47: 492-507. PMID 18085536 DOI: 10.1002/mc.20407  1
2008 Zhang S, Rowlands C, Safe S. Ligand-dependent interactions of the Ah receptor with coactivators in a mammalian two-hybrid assay. Toxicology and Applied Pharmacology. 227: 196-206. PMID 18048071 DOI: 10.1016/j.taap.2007.10.019  0.56
2008 Tjalkens RB, Liu X, Mohl B, Wright T, Moreno JA, Carbone DL, Safe S. The peroxisome proliferator-activated receptor-gamma agonist 1,1-bis(3'-indolyl)-1-(p-trifluoromethylphenyl)methane suppresses manganese-induced production of nitric oxide in astrocytes and inhibits apoptosis in cocultured PC12 cells. Journal of Neuroscience Research. 86: 618-29. PMID 18041089 DOI: 10.1002/jnr.21524  0.56
2008 Higgins KJ, Liu S, Abdelrahim M, Vanderlaag K, Liu X, Porter W, Metz R, Safe S. Vascular endothelial growth factor receptor-2 expression is down-regulated by 17beta-estradiol in MCF-7 breast cancer cells by estrogen receptor alpha/Sp proteins. Molecular Endocrinology (Baltimore, Md.). 22: 388-402. PMID 18006642 DOI: 10.1210/me.2007-0319  0.76
2008 Papineni S, Chintharlapalli S, Safe S. Methyl 2-cyano-3,11-dioxo-18 beta-olean-1,12-dien-30-oate is a peroxisome proliferator-activated receptor-gamma agonist that induces receptor-independent apoptosis in LNCaP prostate cancer cells. Molecular Pharmacology. 73: 553-65. PMID 17989348 DOI: 10.1124/mol.107.041285  1
2008 Cho SD, Lei P, Abdelrahim M, Yoon K, Liu S, Guo J, Papineni S, Chintharlapalli S, Safe S. 1,1-bis(3'-indolyl)-1-(p-methoxyphenyl)methane activates Nur77-independent proapoptotic responses in colon cancer cells. Molecular Carcinogenesis. 47: 252-63. PMID 17957723 DOI: 10.1002/mc.20378  1
2007 Mertens-Talcott SU, Chintharlapalli S, Li X, Safe S. The oncogenic microRNA-27a targets genes that regulate specificity protein transcription factors and the G2-M checkpoint in MDA-MB-231 breast cancer cells. Cancer Research. 67: 11001-11. PMID 18006846 DOI: 10.1158/0008-5472.CAN-07-2416  1
2007 Khan S, Wu F, Liu S, Wu Q, Safe S. Role of specificity protein transcription factors in estrogen-induced gene expression in MCF-7 breast cancer cells. Journal of Molecular Endocrinology. 39: 289-304. PMID 17909268 DOI: 10.1677/JME-07-0043  0.76
2007 Chintharlapalli S, Papineni S, Liu S, Jutooru I, Chadalapaka G, Cho SD, Murthy RS, You Y, Safe S. 2-cyano-lup-1-en-3-oxo-20-oic acid, a cyano derivative of betulinic acid, activates peroxisome proliferator-activated receptor gamma in colon and pancreatic cancer cells. Carcinogenesis. 28: 2337-46. PMID 17724373 DOI: 10.1093/carcin/bgm189  0.96
2007 Chintharlapalli S, Papineni S, Jutooru I, McAlees A, Safe S. Structure-dependent activity of glycyrrhetinic acid derivatives as peroxisome proliferator-activated receptor {gamma} agonists in colon cancer cells. Molecular Cancer Therapeutics. 6: 1588-98. PMID 17513608 DOI: 10.1158/1535-7163.MCT-07-0022  1
2007 Chintharlapalli S, Papineni S, Ramaiah SK, Safe S. Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors. Cancer Research. 67: 2816-23. PMID 17363604 DOI: 10.1158/0008-5472.CAN-06-3735  1
2007 Chintharlapalli S, Papineni S, Safe S. 1,1-bis(3'-indolyl)-1-(p-substitutedphenyl)methanes inhibit growth, induce apoptosis, and decrease the androgen receptor in LNCaP prostate cancer cells through peroxisome proliferator-activated receptor gamma-independent pathways. Molecular Pharmacology. 71: 558-69. PMID 17093136 DOI: 10.1124/mol.106.028696  1
2006 Safe S, Papineni S. The role of xenoestrogenic compounds in the development of breast cancer. Trends in Pharmacological Sciences. 27: 447-54. PMID 16822555 DOI: 10.1016/j.tips.2006.06.006  1
2006 Chintharlapalli S, Papineni S, Safe S. 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit colon cancer cell and tumor growth through PPARgamma-dependent and PPARgamma-independent pathways. Molecular Cancer Therapeutics. 5: 1362-70. PMID 16731770 DOI: 10.1158/1535-7163.MCT-06-0002  1
2006 Higgins KJ, Abdelrahim M, Liu S, Yoon K, Safe S. Regulation of vascular endothelial growth factor receptor-2 expression in pancreatic cancer cells by Sp proteins. Biochemical and Biophysical Research Communications. 345: 292-301. PMID 16678129 DOI: 10.1016/j.bbrc.2006.04.111  0.76
2006 Khan S, Barhoumi R, Burghardt R, Liu S, Kim K, Safe S. Molecular mechanism of inhibitory aryl hydrocarbon receptor-estrogen receptor/Sp1 cross talk in breast cancer cells. Molecular Endocrinology (Baltimore, Md.). 20: 2199-214. PMID 16675542 DOI: 10.1210/me.2006-0100  1
2006 Ru Lee W, Chen CC, Liu S, Safe S. 17beta-estradiol (E2) induces cdc25A gene expression in breast cancer cells by genomic and non-genomic pathways. Journal of Cellular Biochemistry. 99: 209-20. PMID 16598773 DOI: 10.1002/jcb.20902  0.84
2006 Higgins KJ, Liu S, Abdelrahim M, Yoon K, Vanderlaag K, Porter W, Metz RP, Safe S. Vascular endothelial growth factor receptor-2 expression is induced by 17beta-estradiol in ZR-75 breast cancer cells by estrogen receptor alpha/Sp proteins. Endocrinology. 147: 3285-95. PMID 16574784 DOI: 10.1210/en.2006-0081  0.76
2006 Abdelrahim M, Ariazi E, Kim K, Khan S, Barhoumi R, Burghardt R, Liu S, Hill D, Finnell R, Wlodarczyk B, Jordan VC, Safe S. 3-Methylcholanthrene and other aryl hydrocarbon receptor agonists directly activate estrogen receptor alpha. Cancer Research. 66: 2459-67. PMID 16489053 DOI: 10.1158/0008-5472.CAN-05-3132  1
2005 Chintharlapalli S, Papineni S, Baek SJ, Liu S, Safe S. 1,1-Bis(3'-indolyl)-1-(p-substitutedphenyl)methanes are peroxisome proliferator-activated receptor gamma agonists but decrease HCT-116 colon cancer cell survival through receptor-independent activation of early growth response-1 and nonsteroidal anti-inflammatory drug-activated gene-1. Molecular Pharmacology. 68: 1782-92. PMID 16155208 DOI: 10.1124/mol.105.017046  1
2005 Chintharlapalli S, Burghardt R, Papineni S, Ramaiah S, Yoon K, Safe S. Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways. The Journal of Biological Chemistry. 280: 24903-14. PMID 15871945 DOI: 10.1074/jbc.M500107200  1
2005 Contractor R, Samudio IJ, Estrov Z, Harris D, McCubrey JA, Safe SH, Andreeff M, Konopleva M. A novel ring-substituted diindolylmethane,1,1-bis[3'-(5-methoxyindolyl)]-1-(p-t-butylphenyl) methane, inhibits extracellular signal-regulated kinase activation and induces apoptosis in acute myelogenous leukemia. Cancer Research. 65: 2890-8. PMID 15805291 DOI: 10.1158/0008-5472.CAN-04-3781  0.44
2005 Chintharlapalli S, Papineni S, Konopleva M, Andreef M, Samudio I, Safe S. 2-Cyano-3,12-dioxoolean-1,9-dien-28-oic acid and related compounds inhibit growth of colon cancer cells through peroxisome proliferator-activated receptor gamma-dependent and -independent pathways. Molecular Pharmacology. 68: 119-28. PMID 15798084 DOI: 10.1124/mol.105.011437  1
2005 Kim K, Barhoumi R, Burghardt R, Safe S. Analysis of estrogen receptor alpha-Sp1 interactions in breast cancer cells by fluorescence resonance energy transfer. Molecular Endocrinology (Baltimore, Md.). 19: 843-54. PMID 15637147 DOI: 10.1210/me.2004-0326  1
2005 Lee JE, Kim K, Sacchettini JC, Smith CV, Safe S. DRIP150 coactivation of estrogen receptor alpha in ZR-75 breast cancer cells is independent of LXXLL motifs. The Journal of Biological Chemistry. 280: 8819-30. PMID 15625066 DOI: 10.1074/jbc.M413184200  1
2004 Wu Q, Burghardt R, Safe S. Vitamin D-interacting protein 205 (DRIP205) coactivation of estrogen receptor alpha (ERalpha) involves multiple domains of both proteins. The Journal of Biological Chemistry. 279: 53602-12. PMID 15471764 DOI: 10.1074/jbc.M409778200  0.76
2004 Chen CC, Lee WR, Safe S. Egr-1 is activated by 17beta-estradiol in MCF-7 cells by mitogen-activated protein kinase-dependent phosphorylation of ELK-1. Journal of Cellular Biochemistry. 93: 1063-74. PMID 15449318 DOI: 10.1002/jcb.20257  0.84
2004 Li X, Qin C, Burghardt R, Safe S. Hormonal regulation of lactate dehydrogenase-A through activation of protein kinase C pathways in MCF-7 breast cancer cells. Biochemical and Biophysical Research Communications. 320: 625-34. PMID 15240094 DOI: 10.1016/j.bbrc.2004.05.205  0.76
2004 Qin C, Samudio I, Ngwenya S, Safe S. Estrogen-dependent regulation of ornithine decarboxylase in breast cancer cells through activation of nongenomic cAMP-dependent pathways. Molecular Carcinogenesis. 40: 160-70. PMID 15224348 DOI: 10.1002/mc.20030  0.72
2004 Safe S, Kim K. Nuclear receptor-mediated transactivation through interaction with Sp proteins. Progress in Nucleic Acid Research and Molecular Biology. 77: 1-36. PMID 15196889 DOI: 10.1016/S0079-6603(04)77001-4  1
2004 Qin C, Morrow D, Stewart J, Spencer K, Porter W, Smith R, Phillips T, Abdelrahim M, Samudio I, Safe S. A new class of peroxisome proliferator-activated receptor gamma (PPARgamma) agonists that inhibit growth of breast cancer cells: 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes. Molecular Cancer Therapeutics. 3: 247-60. PMID 15026545  0.72
2004 Morrow D, Qin C, Smith R, Safe S. Aryl hydrocarbon receptor-mediated inhibition of LNCaP prostate cancer cell growth and hormone-induced transactivation. The Journal of Steroid Biochemistry and Molecular Biology. 88: 27-36. PMID 15026081 DOI: 10.1016/j.jsbmb.2003.10.005  0.64
2004 Stoner M, Wormke M, Saville B, Samudio I, Qin C, Abdelrahim M, Safe S. Estrogen regulation of vascular endothelial growth factor gene expression in ZR-75 breast cancer cells through interaction of estrogen receptor alpha and SP proteins. Oncogene. 23: 1052-63. PMID 14647449 DOI: 10.1038/sj.onc.1207201  0.96
2003 Zhang S, Qin C, Safe SH. Flavonoids as aryl hydrocarbon receptor agonists/antagonists: effects of structure and cell context. Environmental Health Perspectives. 111: 1877-82. PMID 14644660  0.64
2003 Castro-Rivera E, Safe S. 17 beta-estradiol- and 4-hydroxytamoxifen-induced transactivation in breast, endometrial and liver cancer cells is dependent on ER-subtype, cell and promoter context. The Journal of Steroid Biochemistry and Molecular Biology. 84: 23-31. PMID 12648521  0.52
2003 Qin C, Burghardt R, Smith R, Wormke M, Stewart J, Safe S. Peroxisome proliferator-activated receptor gamma agonists induce proteasome-dependent degradation of cyclin D1 and estrogen receptor alpha in MCF-7 breast cancer cells. Cancer Research. 63: 958-64. PMID 12615709  0.76
2003 Kim K, Thu N, Saville B, Safe S. Domains of estrogen receptor alpha (ERalpha) required for ERalpha/Sp1-mediated activation of GC-rich promoters by estrogens and antiestrogens in breast cancer cells. Molecular Endocrinology (Baltimore, Md.). 17: 804-17. PMID 12576490 DOI: 10.1210/me.2002-0406  1
2002 Qin C, Nguyen T, Stewart J, Samudio I, Burghardt R, Safe S. Estrogen up-regulation of p53 gene expression in MCF-7 breast cancer cells is mediated by calmodulin kinase IV-dependent activation of a nuclear factor kappaB/CCAAT-binding transcription factor-1 complex. Molecular Endocrinology (Baltimore, Md.). 16: 1793-809. PMID 12145335 DOI: 10.1210/me.2002-0006  0.76
2002 Duan R, Xie W, Li X, McDougal A, Safe S. Estrogen regulation of c-fos gene expression through phosphatidylinositol-3-kinase-dependent activation of serum response factor in MCF-7 breast cancer cells. Biochemical and Biophysical Research Communications. 294: 384-94. PMID 12051724 DOI: 10.1016/S0006-291X(02)00499-0  0.76
2001 Stewart DM, Johnson GA, Vyhlidal CA, Burghardt RC, Safe SH, Yu-Lee LY, Bazer FW, Spencer TE. Interferon-τ Activates Multiple Signal Transducer and Activator of Transcription Proteins and Has Complex Effects on Interferon-Responsive Gene Transcription in Ovine Endometrial Epithelial Cells* * This work was supported by NIH Grant HD-32534 (to F.W.B. and T.E.S.) and in part by NIH Grant P30-ES-09106. The publication costs of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact. Endocrinology. 142: 98-107. PMID 28201367 DOI: 10.1210/endo.142.1.7891  0.4
2001 Castro-Rivera E, Samudio I, Safe S. Estrogen regulation of cyclin D1 gene expression in ZR-75 breast cancer cells involves multiple enhancer elements. The Journal of Biological Chemistry. 276: 30853-61. PMID 11410592 DOI: 10.1074/jbc.M103339200  0.72
2001 Xie W, Duan R, Safe S. Activation of adenosine deaminase in MCF-7 cells through IGF-estrogen receptor alpha crosstalk. Journal of Molecular Endocrinology. 26: 217-28. PMID 11357058 DOI: 10.1677/jme.0.0260217  0.96
2001 Qin C, Wilson C, Blancher C, Taylor M, Safe S, Harris AL. Association of ARNT splice variants with estrogen receptor-negative breast cancer, poor induction of vascular endothelial growth factor under hypoxia, and poor prognosis. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 7: 818-23. PMID 11309328  0.64
2001 Porter W, Wang F, Duan R, Qin C, Castro-Rivera E, Kim K, Safe S. Transcriptional activation of heat shock protein 27 gene expression by 17beta-estradiol and modulation by antiestrogens and aryl hydrocarbon receptor agonists. Journal of Molecular Endocrinology. 26: 31-42. PMID 11174852  1
2001 Duan R, Xie W, Burghardt RC, Safe S. Estrogen receptor-mediated activation of the serum response element in MCF-7 cells through MAPK-dependent phosphorylation of Elk-1. The Journal of Biological Chemistry. 276: 11590-8. PMID 11145955 DOI: 10.1074/jbc.M005492200  0.72
2001 Stewart MD, Stewart DM, Johnson GA, Vyhlidal CA, Burghardt RC, Safe SH, Yu-Lee LY, Bazer FW, Spencer TE. Interferon-tau activates multiple signal transducer and activator of transcription proteins and has complex effects on interferon-responsive gene transcription in ovine endometrial epithelial cells. Endocrinology. 142: 98-107. PMID 11145571 DOI: 10.1210/endo.142.1.7891  0.4
2000 Xie W, Duan R, Chen I, Samudio I, Safe S. Transcriptional Activation of Thymidylate Synthase by 17β-Estradiol in MCF-7 Human Breast Cancer Cells. Endocrinology. 141: 2439-2449. PMID 28201107 DOI: 10.1210/endo.141.7.7538  0.72
2000 Xie W, Barwick JL, Simon CM, Pierce AM, Safe S, Blumberg B, Guzelian PS, Evans RM. Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR. Genes & Development. 14: 3014-23. PMID 11114890  0.72
2000 Xie W, Duan R, Chen I, Samudio I, Safe S. Transcriptional activation of thymidylate synthase by 17beta-estradiol in MCF-7 human breast cancer cells. Endocrinology. 141: 2439-49. PMID 10875244 DOI: 10.1210/endo.141.7.7538  0.72
2000 Wormke M, Castro-Rivera E, Chen I, Safe S. Estrogen and aryl hydrocarbon receptor expression and crosstalk in human Ishikawa endometrial cancer cells. The Journal of Steroid Biochemistry and Molecular Biology. 72: 197-207. PMID 10822009  0.72
2000 McDougal A, Sethi Gupta M, Ramamoorthy K, Sun G, Safe SH. Inhibition of carcinogen-induced rat mammary tumor growth and other estrogen-dependent responses by symmetrical dihalo-substituted analogs of diindolylmethane. Cancer Letters. 151: 169-79. PMID 10738111  1
1999 Qin C, Singh P, Safe S. Transcriptional Activation of Insulin-Like Growth Factor-Binding Protein-4 by 17β-Estradiol in MCF-7 Cells: Role of Estrogen Receptor-Sp1 Complexes. Endocrinology. 140: 2501-2508. PMID 28200910 DOI: 10.1210/endo.140.6.6751  0.64
1999 Xie W, Duan R, Safe S. Estrogen Induces Adenosine Deaminase Gene Expression in MCF-7 Human Breast Cancer Cells: Role of Estrogen Receptor-Sp1 Interactions* *This work was supported by the National Institutes of Health (Grant CA-76636), the Welch Foundation, and the Texas Agricultural Experiment Station. Endocrinology. 140: 219-227. PMID 28200731 DOI: 10.1210/endo.140.1.6394  0.72
1999 Safe S, Qin C, McDougal A. Development of selective aryl hydrocarbon receptor modulators for treatment of breast cancer. Expert Opinion On Investigational Drugs. 8: 1385-96. PMID 15992156 DOI: 10.1517/13543784.8.9.1385  0.64
1999 Castro-Rivera E, Wormke M, Safe S. Estrogen and aryl hydrocarbon responsiveness of ECC-1 endometrial cancer cells. Molecular and Cellular Endocrinology. 150: 11-21. PMID 10411295  0.52
1999 Qin C, Singh P, Safe S. Transcriptional activation of insulin-like growth factor-binding protein-4 by 17beta-estradiol in MCF-7 cells: role of estrogen receptor-Sp1 complexes. Endocrinology. 140: 2501-8. PMID 10342835 DOI: 10.1210/endo.140.6.6751  0.64
1999 Ramamoorthy K, Gupta MS, Sun G, McDougal A, Safe SH. 3,3'4,4'-Tetrachlorobiphenyl exhibits antiestrogenic and antitumorigenic activity in the rodent uterus and mammary cells and in human breast cancer cells. Carcinogenesis. 20: 115-23. PMID 9934858  1
1999 Xie W, Duan R, Safe S. Estrogen induces adenosine deaminase gene expression in MCF-7 human breast cancer cells: role of estrogen receptor-Sp1 interactions. Endocrinology. 140: 219-27. PMID 9886828 DOI: 10.1210/endo.140.1.6394  0.72
1998 Sun G, Porter W, Safe S. Estrogen-induced retinoic acid receptor alpha 1 gene expression: role of estrogen receptor-Sp1 complex. Molecular Endocrinology (Baltimore, Md.). 12: 882-90. PMID 9626663 DOI: 10.1210/mend.12.6.0125  1
1998 Castro-Rivera E, Safe S. Estrogen- and antiestrogen-responsiveness of HEC1A endometrial adenocarcinoma cells in culture. The Journal of Steroid Biochemistry and Molecular Biology. 64: 287-95. PMID 9618030  0.52
1997 Wilson CL, Thomsen J, Hoivik DJ, Wormke MT, Stanker L, Holtzapple C, Safe SH. Aryl hydrocarbon (Ah) nonresponsiveness in estrogen receptor-negative MDA-MB-231 cells is associated with expression of a variant arnt protein. Archives of Biochemistry and Biophysics. 346: 65-73. PMID 9328285 DOI: 10.1006/abbi.1997.0289  0.4
1997 Sun G, Safe S. Antiestrogenic activities of alternate-substituted polychlorinated dibenzofurans in MCF-7 human breast cancer cells. Cancer Chemotherapy and Pharmacology. 40: 239-44. PMID 9219508 DOI: 10.1007/s002800050653  1
1996 Lu YF, Sun G, Wang X, Safe S. Inhibition of prolactin receptor gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin in MCF-7 human breast cancer cells. Archives of Biochemistry and Biophysics. 332: 35-40. PMID 8806706 DOI: 10.1006/abbi.1996.0313  1
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