Stephen Safe - Publications

Affiliations: 
Texas A & M University, College Station, TX, United States 
Area:
Molecular Biology, Biochemistry
Website:
https://biochemistry.tamu.edu/people/safe-steven/

232 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Shrestha R, Mohankumar K, Jin UH, Martin GG, Safe S. THE HISTONE METHYLTRANSFERASE GENE G9A IS REGULATED BY NUCLEAR RECEPTOR 4A1 (NR4A1) IN ALVEOLAR RHABDOMYOSARCOMA CELLS. Molecular Cancer Therapeutics. PMID 33277444 DOI: 10.1158/1535-7163.MCT-20-0474  0.302
2019 Yoon K, Chen CC, Orr AA, Barreto PN, Tamamis P, Safe S. Activation of COUP-TFI by a Novel Diindolylmethane Derivative. Cells. 8. PMID 30866413 DOI: 10.3390/Cells8030220  0.611
2019 Kasiappan R, Jutooru I, Mohankumar K, Karki K, Lacey A, Safe S. Reactive Oxygen Species (ROS)-inducing Triterpenoid Inhibits Rhabdomyosarcoma Cell and Tumor Growth through Targeting Sp Transcription Factors. Molecular Cancer Research : McR. PMID 30610105 DOI: 10.1158/1541-7786.Mcr-18-1071  0.739
2018 Cheng Y, Imanirad P, Jutooru I, Hedrick E, Jin UH, Rodrigues Hoffman A, Leal de Araujo J, Morpurgo B, Golovko A, Safe S. Role of metastasis-associated lung adenocarcinoma transcript-1 (MALAT-1) in pancreatic cancer. Plos One. 13: e0192264. PMID 29389953 DOI: 10.1371/Journal.Pone.0192264  0.722
2016 Kasiappan R, Jutooru I, Karki K, Hedrick E, Safe SH. Benzylisothiocyanate (BITC) Induces ROS-dependent Repression of STAT3 by Downregulation of Specificity Proteins in Pancreatic Cancer. The Journal of Biological Chemistry. PMID 27875298 DOI: 10.1074/Jbc.M116.746339  0.742
2016 Hedrick E, Cheng Y, Jin UH, Kim K, Safe S. Specificity protein (Sp) transcription factors Sp1, Sp3 and Sp4 are non-oncogene addiction genes in cancer cells. Oncotarget. PMID 26967243 DOI: 10.18632/Oncotarget.7925  0.703
2015 Li X, Pathi SS, Safe S. Sulindac sulfide inhibits colon cancer cell growth and downregulates specificity protein transcription factors. Bmc Cancer. 15: 974. PMID 26673922 DOI: 10.1186/S12885-015-1956-8  0.738
2015 Gandhy SU, Imanirad P, Jin UH, Nair V, Hedrick E, Cheng Y, Corton JC, Kim K, Safe S. Specificity protein (Sp) transcription factors and metformin regulate expression of the long non-coding RNA HULC. Oncotarget. PMID 26317792 DOI: 10.18632/Oncotarget.4560  0.705
2015 Hedrick E, Lee SO, Doddapaneni R, Singh M, Safe S. Nuclear Receptor 4A1 (NR4A1) as a Drug Target for Breast Cancer Chemotherapy. Endocrine-Related Cancer. PMID 26229035 DOI: 10.1530/Erc-15-0063  0.31
2015 Cheng Y, Jutooru I, Chadalapaka G, Corton JC, Safe S. The long non-coding RNA HOTTIP enhances pancreatic cancer cell proliferation, survival and migration. Oncotarget. 6: 10840-52. PMID 25912306 DOI: 10.18632/Oncotarget.3450  0.731
2014 Yang WS, Chadalapaka G, Cho SG, Lee SO, Jin UH, Jutooru I, Choi K, Leung YK, Ho SM, Safe S, Kim K. The transcriptional repressor ZBTB4 regulates EZH2 through a MicroRNA-ZBTB4-specificity protein signaling axis. Neoplasia (New York, N.Y.). 16: 1059-69. PMID 25499219 DOI: 10.1016/J.Neo.2014.09.011  0.803
2014 Lee SO, Li X, Hedrick E, Jin UH, Tjalkens RB, Backos DS, Li L, Zhang Y, Wu Q, Safe S. Diindolylmethane analogs bind NR4A1 and are NR4A1 antagonists in colon cancer cells. Molecular Endocrinology (Baltimore, Md.). 28: 1729-39. PMID 25099012 DOI: 10.1210/Me.2014-1102  0.464
2014 Safe S, Imanirad P, Sreevalsan S, Nair V, Jutooru I. Transcription factor Sp1, also known as specificity protein 1 as a therapeutic target. Expert Opinion On Therapeutic Targets. 18: 759-69. PMID 24793594 DOI: 10.1517/14728222.2014.914173  0.706
2014 Zhang Z, Kim K, Li X, Moreno M, Sharp T, Goodheart MJ, Safe S, Dupuy AJ, Amendt BA. MicroRNA-26b represses colon cancer cell proliferation by inhibiting lymphoid enhancer factor 1 expression. Molecular Cancer Therapeutics. 13: 1942-51. PMID 24785257 DOI: 10.1158/1535-7163.Mct-13-1000  0.702
2014 Jutooru I, Guthrie AS, Chadalapaka G, Pathi S, Kim K, Burghardt R, Jin UH, Safe S. Mechanism of action of phenethylisothiocyanate and other reactive oxygen species-inducing anticancer agents. Molecular and Cellular Biology. 34: 2382-95. PMID 24732804 DOI: 10.1128/Mcb.01602-13  0.79
2014 Pathi S, Li X, Safe S. Tolfenamic acid inhibits colon cancer cell and tumor growth and induces degradation of specificity protein (Sp) transcription factors. Molecular Carcinogenesis. 53: E53-61. PMID 23670891 DOI: 10.1002/Mc.22010  0.772
2013 Nair V, Pathi S, Jutooru I, Sreevalsan S, Basha R, Abdelrahim M, Samudio I, Safe S. Metformin inhibits pancreatic cancer cell and tumor growth and downregulates Sp transcription factors. Carcinogenesis. 34: 2870-9. PMID 23803693 DOI: 10.1093/Carcin/Bgt231  0.821
2013 Noratto GD, Jutooru I, Safe S, Angel-Morales G, Mertens-Talcott SU. The drug resistance suppression induced by curcuminoids in colon cancer SW-480 cells is mediated by reactive oxygen species-induced disruption of the microRNA-27a-ZBTB10-Sp axis. Molecular Nutrition & Food Research. 57: 1638-48. PMID 23471840 DOI: 10.1002/Mnfr.201200609  0.723
2013 Chadalapaka G, Jutooru I, Sreevalsan S, Pathi S, Kim K, Chen C, Crose L, Linardic C, Safe S. Inhibition of rhabdomyosarcoma cell and tumor growth by targeting specificity protein (Sp) transcription factors. International Journal of Cancer. 132: 795-806. PMID 22815231 DOI: 10.1002/Ijc.27730  0.806
2013 Kim K, Jutooru I, Chadalapaka G, Johnson G, Frank J, Burghardt R, Kim S, Safe S. HOTAIR is a negative prognostic factor and exhibits pro-oncogenic activity in pancreatic cancer. Oncogene. 32: 1616-25. PMID 22614017 DOI: 10.1038/Onc.2012.193  0.813
2012 Gandhy SU, Kim K, Larsen L, Rosengren RJ, Safe S. Curcumin and synthetic analogs induce reactive oxygen species and decreases specificity protein (Sp) transcription factors by targeting microRNAs. Bmc Cancer. 12: 564. PMID 23194063 DOI: 10.1186/1471-2407-12-564  0.708
2012 Pathi S, Jutooru I, Chadalapaka G, Nair V, Lee SO, Safe S. Aspirin inhibits colon cancer cell and tumor growth and downregulates specificity protein (Sp) transcription factors. Plos One. 7: e48208. PMID 23110215 DOI: 10.1371/Journal.Pone.0048208  0.817
2012 Kim K, Chadalapaka G, Pathi SS, Jin UH, Lee JS, Park YY, Cho SG, Chintharlapalli S, Safe S. Induction of the transcriptional repressor ZBTB4 in prostate cancer cells by drug-induced targeting of microRNA-17-92/106b-25 clusters. Molecular Cancer Therapeutics. 11: 1852-62. PMID 22752225 DOI: 10.1158/1535-7163.Mct-12-0181  0.803
2012 Safe SH, Prather PL, Brents LK, Chadalapaka G, Jutooru I. Unifying mechanisms of action of the anticancer activities of triterpenoids and synthetic analogs. Anti-Cancer Agents in Medicinal Chemistry. 12: 1211-20. PMID 22583404 DOI: 10.2174/187152012803833099  0.741
2012 Liu X, Jutooru I, Lei P, Kim K, Lee SO, Brents LK, Prather PL, Safe S. Betulinic acid targets YY1 and ErbB2 through cannabinoid receptor-dependent disruption of microRNA-27a:ZBTB10 in breast cancer. Molecular Cancer Therapeutics. 11: 1421-31. PMID 22553354 DOI: 10.1158/1535-7163.Mct-12-0026  0.813
2012 Wilson H, Chadalapaka G, Jutooru I, Sheppard S, Pfent C, Safe S. Effect of Tolfenamic Acid on Canine Cancer Cell Proliferation, Specificity Protein (Sp) Transcription Factors, and Sp-Regulated Proteins in Canine Osteosarcoma, Mammary Carcinoma, and Melanoma Cells Journal of Veterinary Internal Medicine. 26: 977-986. PMID 22536857 DOI: 10.1111/J.1939-1676.2012.00931.X  0.739
2012 Chadalapaka G, Jutooru I, Safe S. Celastrol decreases specificity proteins (Sp) and fibroblast growth factor receptor-3 (FGFR3) in bladder cancer cells. Carcinogenesis. 33: 886-94. PMID 22334592 DOI: 10.1093/Carcin/Bgs102  0.73
2012 Park YY, Kim K, Kim SB, Hennessy BT, Kim SM, Park ES, Lim JY, Li J, Lu Y, Gonzalez-Angulo AM, Jeong W, Mills GB, Safe S, Lee JS. Reconstruction of nuclear receptor network reveals that NR2E3 is a novel upstream regulator of ESR1 in breast cancer. Embo Molecular Medicine. 4: 52-67. PMID 22174013 DOI: 10.1002/Emmm.201100187  0.698
2012 Lee SO, Andey T, Jin UH, Kim K, Singh M, Sachdeva M, Safe S. The nuclear receptor TR3 regulates mTORC1 signaling in lung cancer cells expressing wild-type p53. Oncogene. 31: 3265-76. PMID 22081070 DOI: 10.1038/Onc.2011.504  0.706
2012 Zhang S, Kim K, Jin UH, Pfent C, Cao H, Amendt B, Liu X, Wilson-Robles H, Safe S. Aryl hydrocarbon receptor agonists induce microRNA-335 expression and inhibit lung metastasis of estrogen receptor negative breast cancer cells. Molecular Cancer Therapeutics. 11: 108-18. PMID 22034498 DOI: 10.1158/1535-7163.Mct-11-0548  0.713
2012 Kim K, Chadalapaka G, Lee SO, Yamada D, Sastre-Garau X, Defossez PA, Park YY, Lee JS, Safe S. Identification of oncogenic microRNA-17-92/ZBTB4/specificity protein axis in breast cancer. Oncogene. 31: 1034-44. PMID 21765466 DOI: 10.1038/Onc.2011.296  0.678
2012 Kim K, Safe S. Abstract 203: Hotair, a long non-coding RNA, exhibits pro-oncogenic activity in pancreatic cancer Cancer Research. 72: 203-203. DOI: 10.1158/1538-7445.Am2012-203  0.648
2011 Pathi SS, Lei P, Sreevalsan S, Chadalapaka G, Jutooru I, Safe S. Pharmacologic doses of ascorbic acid repress specificity protein (Sp) transcription factors and Sp-regulated genes in colon cancer cells. Nutrition and Cancer. 63: 1133-42. PMID 21919647 DOI: 10.1080/01635581.2011.605984  0.823
2011 Chintharlapalli S, Papineni S, Lei P, Pathi S, Safe S. Betulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and -independent downregulation of specificity proteins (Sp) transcription factors. Bmc Cancer. 11: 371. PMID 21864401 DOI: 10.1186/1471-2407-11-371  0.811
2011 Yoon K, Lee SO, Cho SD, Kim K, Khan S, Safe S. Activation of nuclear TR3 (NR4A1) by a diindolylmethane analog induces apoptosis and proapoptotic genes in pancreatic cancer cells and tumors. Carcinogenesis. 32: 836-42. PMID 21362629 DOI: 10.1093/Carcin/Bgr040  0.783
2011 Abdelbaqi K, Lack N, Guns ET, Kotha L, Safe S, Sanderson JT. Antiandrogenic and growth inhibitory effects of ring-substituted analogs of 3,3'-diindolylmethane (ring-DIMs) in hormone-responsive LNCaP human prostate cancer cells. The Prostate. 71: 1401-12. PMID 21321979 DOI: 10.1002/Pros.21356  0.792
2011 Chintharlapalli S, Papineni S, Lee SO, Lei P, Jin UH, Sherman SI, Santarpia L, Safe S. Inhibition of pituitary tumor-transforming gene-1 in thyroid cancer cells by drugs that decrease specificity proteins. Molecular Carcinogenesis. 50: 655-67. PMID 21268135 DOI: 10.1002/Mc.20738  0.805
2011 Lee SO, Li X, Khan S, Safe S. Targeting NR4A1 (TR3) in cancer cells and tumors. Expert Opinion On Therapeutic Targets. 15: 195-206. PMID 21204731 DOI: 10.1517/14728222.2011.547481  0.571
2011 Kim K, Burghardt R, Barhoumi R, Lee SO, Liu X, Safe S. MDM2 regulates estrogen receptor α and estrogen responsiveness in breast cancer cells. Journal of Molecular Endocrinology. 46: 67-79. PMID 21169420 DOI: 10.1677/Jme-10-0110  0.686
2011 Pathi SS, Jutooru I, Chadalapaka G, Sreevalsan S, Anand S, Thatcher GR, Safe S. GT-094, a NO-NSAID, inhibits colon cancer cell growth by activation of a reactive oxygen species-microRNA-27a: ZBTB10-specificity protein pathway. Molecular Cancer Research : McR. 9: 195-202. PMID 21156786 DOI: 10.1158/1541-7786.Mcr-10-0363  0.821
2011 Lee S, Andey T, Jin U, Kim K, Singh M, Safe S. Abstract 4009: Regulation of mTOR pathway by the orphan nuclear receptor NR4A1 (TR3/Nur77) in non-small cell lung cancer: Role of TR3 in AMPK activation Cellular and Molecular Biology. 71: 4009-4009. DOI: 10.1158/1538-7445.Am2011-4009  0.648
2010 Vanderlaag K, Su Y, Frankel AE, Burghardt RC, Barhoumi R, Chadalapaka G, Jutooru I, Safe S. 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induce autophagic cell death in estrogen receptor negative breast cancer. Bmc Cancer. 10: 669. PMID 21129193 DOI: 10.1186/1471-2407-10-669  0.739
2010 Lee SO, Abdelrahim M, Yoon K, Chintharlapalli S, Papineni S, Kim K, Wang H, Safe S. Inactivation of the orphan nuclear receptor TR3/Nur77 inhibits pancreatic cancer cell and tumor growth. Cancer Research. 70: 6824-36. PMID 20660371 DOI: 10.1158/0008-5472.Can-10-1992  0.817
2010 Jutooru I, Chadalapaka G, Lei P, Safe S. Inhibition of NFkappaB and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein down-regulation. The Journal of Biological Chemistry. 285: 25332-44. PMID 20538607 DOI: 10.1074/Jbc.M109.095240  0.747
2010 Jutooru I, Chadalapaka G, Abdelrahim M, Basha MR, Samudio I, Konopleva M, Andreeff M, Safe S. Methyl 2-cyano-3,12-dioxooleana-1,9-dien-28-oate decreases specificity protein transcription factors and inhibits pancreatic tumor growth: role of microRNA-27a. Molecular Pharmacology. 78: 226-36. PMID 20488920 DOI: 10.1124/Mol.110.064451  0.81
2010 Jutooru I, Chadalapaka G, Sreevalsan S, Lei P, Barhoumi R, Burghardt R, Safe S. Arsenic trioxide downregulates specificity protein (Sp) transcription factors and inhibits bladder cancer cell and tumor growth. Experimental Cell Research. 316: 2174-88. PMID 20435036 DOI: 10.1016/J.Yexcr.2010.04.027  0.743
2010 Chadalapaka G, Jutooru I, Burghardt R, Safe S. Drugs that target specificity proteins downregulate epidermal growth factor receptor in bladder cancer cells. Molecular Cancer Research : McR. 8: 739-50. PMID 20407012 DOI: 10.1158/1541-7786.Mcr-09-0493  0.73
2010 Li X, Mertens-Talcott SU, Zhang S, Kim K, Ball J, Safe S. MicroRNA-27a Indirectly Regulates Estrogen Receptor {alpha} Expression and Hormone Responsiveness in MCF-7 Breast Cancer Cells. Endocrinology. 151: 2462-73. PMID 20382698 DOI: 10.1210/En.2009-1150  0.696
2010 Cho SD, Lee SO, Chintharlapalli S, Abdelrahim M, Khan S, Yoon K, Kamat AM, Safe S. Activation of nerve growth factor-induced B alpha by methylene-substituted diindolylmethanes in bladder cancer cells induces apoptosis and inhibits tumor growth. Molecular Pharmacology. 77: 396-404. PMID 20023005 DOI: 10.1124/Mol.109.061143  0.768
2010 Choi KH, Kim HK, Kim JH, Choi ES, Shin JA, Lee SO, Chintharlapalli S, Safe S, Abdelrahim M, Kong G, Choi HS, Jung JY, Cho HT, Cho NP, Cho SD. The p38 MAPK pathway is critical for 5,5'-dibromodiindolylmethane-induced apoptosis to prevent oral squamous carcinoma cells. European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (Ecp). 19: 153-9. PMID 19949342 DOI: 10.1097/Cej.0B013E328333D088  0.673
2010 Guo J, Chintharlapalli S, Lee SO, Cho SD, Lei P, Papineni S, Safe S. Peroxisome proliferator-activated receptor gamma-dependent activity of indole ring-substituted 1,1-bis(3'-indolyl)-1-(p-biphenyl)methanes in cancer cells. Cancer Chemotherapy and Pharmacology. 66: 141-50. PMID 19823826 DOI: 10.1007/S00280-009-1144-0  0.789
2009 Sreevalsan S, Jutooru I, Chadalapaka G, Walker M, Safe S. 1,1-Bis(3'-indolyl)-1-(p-bromophenyl)methane and related compounds repress survivin and decrease gamma-radiation-induced survivin in colon and pancreatic cancer cells. International Journal of Oncology. 35: 1191-9. PMID 19787275 DOI: 10.3892/Ijo_00000436  0.736
2009 Lee SO, Chintharlapalli S, Liu S, Papineni S, Cho SD, Yoon K, Safe S. p21 expression is induced by activation of nuclear nerve growth factor-induced Balpha (Nur77) in pancreatic cancer cells. Molecular Cancer Research : McR. 7: 1169-78. PMID 19584258 DOI: 10.1158/1541-7786.Mcr-08-0473  0.814
2009 Chintharlapalli S, Papineni S, Abdelrahim M, Abudayyeh A, Jutooru I, Chadalapaka G, Wu F, Mertens-Talcott S, Vanderlaag K, Cho SD, Smith R, Safe S. Oncogenic microRNA-27a is a target for anticancer agent methyl 2-cyano-3,11-dioxo-18beta-olean-1,12-dien-30-oate in colon cancer cells. International Journal of Cancer. 125: 1965-74. PMID 19582879 DOI: 10.1002/Ijc.24530  0.811
2009 Zhang S, Lei P, Liu X, Li X, Walker K, Kotha L, Rowlands C, Safe S. The aryl hydrocarbon receptor as a target for estrogen receptor-negative breast cancer chemotherapy. Endocrine-Related Cancer. 16: 835-44. PMID 19447902 DOI: 10.1677/Erc-09-0054  0.831
2009 Papineni S, Chintharlapalli S, Abdelrahim M, Lee SO, Burghardt R, Abudayyeh A, Baker C, Herrera L, Safe S. Tolfenamic acid inhibits esophageal cancer through repression of specificity proteins and c-Met. Carcinogenesis. 30: 1193-201. PMID 19406933 DOI: 10.1093/Carcin/Bgp092  0.814
2009 Jutooru I, Chadalapaka G, Chintharlapalli S, Papineni S, Safe S. Induction of apoptosis and nonsteroidal anti-inflammatory drug-activated gene 1 in pancreatic cancer cells by a glycyrrhetinic acid derivative. Molecular Carcinogenesis. 48: 692-702. PMID 19125423 DOI: 10.1002/Mc.20518  0.819
2008 Inamoto T, Papineni S, Chintharlapalli S, Cho SD, Safe S, Kamat AM. 1,1-Bis(3'-indolyl)-1-(p-chlorophenyl)methane activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth. Molecular Cancer Therapeutics. 7: 3825-33. PMID 19074857 DOI: 10.1158/1535-7163.Mct-08-0730  0.808
2008 Safe S, Kim K, Kim K. Non-classical genomic estrogen receptor (ER)/specificity protein and ER/activating protein-1 signaling pathways. Journal of Molecular Endocrinology. 41: 263-75. PMID 18772268 DOI: 10.1677/Jme-08-0103  0.679
2008 Cho SD, Chintharlapalli S, Abdelrahim M, Papineni S, Liu S, Guo J, Lei P, Abudayyeh A, Safe S. 5,5'-Dibromo-bis(3'-indolyl)methane induces Kruppel-like factor 4 and p21 in colon cancer cells. Molecular Cancer Therapeutics. 7: 2109-20. PMID 18645021 DOI: 10.1158/1535-7163.Mct-07-2311  0.796
2008 Wu F, Xu R, Kim K, Martin J, Safe S. In vivo profiling of estrogen receptor/specificity protein-dependent transactivation. Endocrinology. 149: 5696-705. PMID 18635651 DOI: 10.1210/En.2008-0720  0.71
2008 Chadalapaka G, Jutooru I, Chintharlapalli S, Papineni S, Smith R, Li X, Safe S. Curcumin decreases specificity protein expression in bladder cancer cells. Cancer Research. 68: 5345-54. PMID 18593936 DOI: 10.1158/0008-5472.Can-07-6805  0.818
2008 Safe S, Papineni S, Chintharlapalli S. Cancer chemotherapy with indole-3-carbinol, bis(3'-indolyl)methane and synthetic analogs. Cancer Letters. 269: 326-38. PMID 18501502 DOI: 10.1016/J.Canlet.2008.04.021  0.815
2008 Lei P, Abdelrahim M, Cho SD, Liu S, Chintharlapalli S, Safe S. 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit colon cancer cell and tumor growth through activation of c-jun N-terminal kinase. Carcinogenesis. 29: 1139-47. PMID 18460448 DOI: 10.1093/Carcin/Bgn103  0.677
2008 Wu F, Khan S, Wu Q, Barhoumi R, Burghardt R, Safe S. Ligand structure-dependent activation of estrogen receptor alpha/Sp by estrogens and xenoestrogens. The Journal of Steroid Biochemistry and Molecular Biology. 110: 104-15. PMID 18400491 DOI: 10.1016/J.Jsbmb.2008.02.008  0.675
2008 Chadalapaka G, Jutooru I, McAlees A, Stefanac T, Safe S. Structure-dependent inhibition of bladder and pancreatic cancer cell growth by 2-substituted glycyrrhetinic and ursolic acid derivatives. Bioorganic & Medicinal Chemistry Letters. 18: 2633-9. PMID 18359628 DOI: 10.1016/J.Bmcl.2008.03.031  0.723
2008 Hong J, Samudio I, Chintharlapalli S, Safe S. 1,1-bis(3'-indolyl)-1-(p-substituted phenyl)methanes decrease mitochondrial membrane potential and induce apoptosis in endometrial and other cancer cell lines. Molecular Carcinogenesis. 47: 492-507. PMID 18085536 DOI: 10.1002/Mc.20407  0.751
2008 Zhang S, Rowlands C, Safe S. Ligand-dependent interactions of the Ah receptor with coactivators in a mammalian two-hybrid assay. Toxicology and Applied Pharmacology. 227: 196-206. PMID 18048071 DOI: 10.1016/J.Taap.2007.10.019  0.327
2008 York M, Abdelrahim M, Chintharlapalli S, Lucero SD, Safe S. 1,1-bis(3'-indolyl)-1-(p-substitutedphenyl)methanes induce apoptosis and inhibit renal cell carcinoma growth. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 13: 6743-52. PMID 18006776 DOI: 10.1158/1078-0432.Ccr-07-0967  0.605
2008 Higgins KJ, Liu S, Abdelrahim M, Vanderlaag K, Liu X, Porter W, Metz R, Safe S. Vascular endothelial growth factor receptor-2 expression is down-regulated by 17beta-estradiol in MCF-7 breast cancer cells by estrogen receptor alpha/Sp proteins. Molecular Endocrinology (Baltimore, Md.). 22: 388-402. PMID 18006642 DOI: 10.1210/Me.2007-0319  0.82
2008 Papineni S, Chintharlapalli S, Safe S. Methyl 2-cyano-3,11-dioxo-18 beta-olean-1,12-dien-30-oate is a peroxisome proliferator-activated receptor-gamma agonist that induces receptor-independent apoptosis in LNCaP prostate cancer cells. Molecular Pharmacology. 73: 553-65. PMID 17989348 DOI: 10.1124/Mol.107.041285  0.796
2008 Cho SD, Lei P, Abdelrahim M, Yoon K, Liu S, Guo J, Papineni S, Chintharlapalli S, Safe S. 1,1-bis(3'-indolyl)-1-(p-methoxyphenyl)methane activates Nur77-independent proapoptotic responses in colon cancer cells. Molecular Carcinogenesis. 47: 252-63. PMID 17957723 DOI: 10.1002/Mc.20378  0.803
2008 Vanderlaag K, Su Y, Frankel AE, Grage H, Smith R, Khan S, Safe S. 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit proliferation of estrogen receptor-negative breast cancer cells by activation of multiple pathways. Breast Cancer Research and Treatment. 109: 273-83. PMID 17624585 DOI: 10.1007/S10549-007-9648-Y  0.622
2007 Mertens-Talcott SU, Chintharlapalli S, Li X, Safe S. The oncogenic microRNA-27a targets genes that regulate specificity protein transcription factors and the G2-M checkpoint in MDA-MB-231 breast cancer cells. Cancer Research. 67: 11001-11. PMID 18006846 DOI: 10.1158/0008-5472.Can-07-2416  0.671
2007 Khan S, Wu F, Liu S, Wu Q, Safe S. Role of specificity protein transcription factors in estrogen-induced gene expression in MCF-7 breast cancer cells. Journal of Molecular Endocrinology. 39: 289-304. PMID 17909268 DOI: 10.1677/Jme-07-0043  0.661
2007 Su Y, Vanderlaag K, Ireland C, Ortiz J, Grage H, Safe S, Frankel AE. 1,1-Bis(3'-indolyl)-1-(p-biphenyl)methane inhibits basal-like breast cancer growth in athymic nude mice. Breast Cancer Research : Bcr. 9: R56. PMID 17764562 DOI: 10.1186/Bcr1761  0.811
2007 Chintharlapalli S, Papineni S, Liu S, Jutooru I, Chadalapaka G, Cho SD, Murthy RS, You Y, Safe S. 2-cyano-lup-1-en-3-oxo-20-oic acid, a cyano derivative of betulinic acid, activates peroxisome proliferator-activated receptor gamma in colon and pancreatic cancer cells. Carcinogenesis. 28: 2337-46. PMID 17724373 DOI: 10.1093/Carcin/Bgm189  0.818
2007 Khan S, Liu S, Stoner M, Safe S. Cobaltous chloride and hypoxia inhibit aryl hydrocarbon receptor-mediated responses in breast cancer cells Toxicology and Applied Pharmacology. 223: 28-38. PMID 17599377 DOI: 10.1016/J.Taap.2007.05.010  0.82
2007 Reddivari L, Vanamala J, Chintharlapalli S, Safe SH, Miller JC. Anthocyanin fraction from potato extracts is cytotoxic to prostate cancer cells through activation of caspase-dependent and caspase-independent pathways. Carcinogenesis. 28: 2227-35. PMID 17522067 DOI: 10.1093/Carcin/Bgm117  0.605
2007 Chintharlapalli S, Papineni S, Jutooru I, McAlees A, Safe S. Structure-dependent activity of glycyrrhetinic acid derivatives as peroxisome proliferator-activated receptor {gamma} agonists in colon cancer cells. Molecular Cancer Therapeutics. 6: 1588-98. PMID 17513608 DOI: 10.1158/1535-7163.Mct-07-0022  0.824
2007 Chintharlapalli S, Papineni S, Ramaiah SK, Safe S. Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors. Cancer Research. 67: 2816-23. PMID 17363604 DOI: 10.1158/0008-5472.Can-06-3735  0.796
2007 Cho SD, Yoon K, Chintharlapalli S, Abdelrahim M, Lei P, Hamilton S, Khan S, Ramaiah SK, Safe S. Nur77 agonists induce proapoptotic genes and responses in colon cancer cells through nuclear receptor-dependent and nuclear receptor-independent pathways. Cancer Research. 67: 674-83. PMID 17234778 DOI: 10.1158/0008-5472.Can-06-2907  0.766
2007 Chintharlapalli S, Papineni S, Safe S. 1,1-bis(3'-indolyl)-1-(p-substitutedphenyl)methanes inhibit growth, induce apoptosis, and decrease the androgen receptor in LNCaP prostate cancer cells through peroxisome proliferator-activated receptor gamma-independent pathways. Molecular Pharmacology. 71: 558-69. PMID 17093136 DOI: 10.1124/Mol.106.028696  0.801
2006 Liu S, Abdelrahim M, Khan S, Ariazi E, Jordan VC, Safe S. Aryl hydrocarbon receptor agonists directly activate estrogen receptor alpha in MCF-7 breast cancer cells. Biological Chemistry. 387: 1209-13. PMID 16972788 DOI: 10.1515/Bc.2006.149  0.603
2006 Safe S, Papineni S. The role of xenoestrogenic compounds in the development of breast cancer. Trends in Pharmacological Sciences. 27: 447-54. PMID 16822555 DOI: 10.1016/J.Tips.2006.06.006  0.694
2006 Khan S, Konstantinov A, Chittim B, McAlees A, Yeo B, Safe S. Structure-dependent Ah receptor agonist activities of chlorinated biphenylenes. Toxicology in Vitro : An International Journal Published in Association With Bibra. 20: 1234-7. PMID 16759834 DOI: 10.1016/J.Tiv.2006.04.003  0.518
2006 Chintharlapalli S, Papineni S, Safe S. 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes inhibit colon cancer cell and tumor growth through PPARgamma-dependent and PPARgamma-independent pathways. Molecular Cancer Therapeutics. 5: 1362-70. PMID 16731770 DOI: 10.1158/1535-7163.Mct-06-0002  0.812
2006 Higgins KJ, Abdelrahim M, Liu S, Yoon K, Safe S. Regulation of vascular endothelial growth factor receptor-2 expression in pancreatic cancer cells by Sp proteins. Biochemical and Biophysical Research Communications. 345: 292-301. PMID 16678129 DOI: 10.1016/J.Bbrc.2006.04.111  0.8
2006 Khan S, Barhoumi R, Burghardt R, Liu S, Kim K, Safe S. Molecular mechanism of inhibitory aryl hydrocarbon receptor-estrogen receptor/Sp1 cross talk in breast cancer cells. Molecular Endocrinology (Baltimore, Md.). 20: 2199-214. PMID 16675542 DOI: 10.1210/Me.2006-0100  0.787
2006 Ru Lee W, Chen CC, Liu S, Safe S. 17beta-estradiol (E2) induces cdc25A gene expression in breast cancer cells by genomic and non-genomic pathways. Journal of Cellular Biochemistry. 99: 209-20. PMID 16598773 DOI: 10.1002/Jcb.20902  0.604
2006 Higgins KJ, Liu S, Abdelrahim M, Yoon K, Vanderlaag K, Porter W, Metz RP, Safe S. Vascular endothelial growth factor receptor-2 expression is induced by 17beta-estradiol in ZR-75 breast cancer cells by estrogen receptor alpha/Sp proteins. Endocrinology. 147: 3285-95. PMID 16574784 DOI: 10.1210/En.2006-0081  0.815
2006 Abdelrahim M, Ariazi E, Kim K, Khan S, Barhoumi R, Burghardt R, Liu S, Hill D, Finnell R, Wlodarczyk B, Jordan VC, Safe S. 3-Methylcholanthrene and other aryl hydrocarbon receptor agonists directly activate estrogen receptor alpha. Cancer Research. 66: 2459-67. PMID 16489053 DOI: 10.1158/0008-5472.Can-05-3132  0.771
2006 Kassouf W, Chintharlapalli S, Abdelrahim M, Nelkin G, Safe S, Kamat AM. Inhibition of bladder tumor growth by 1,1-bis(3'-indolyl)-1-(p-substitutedphenyl)methanes: a new class of peroxisome proliferator-activated receptor gamma agonists. Cancer Research. 66: 412-8. PMID 16397256 DOI: 10.1158/0008-5472.Can-05-2755  0.605
2006 Samudio I, Konopleva M, Safe S, McQueen T, Andreeff M. Guggulsterones induce apoptosis and differentiation in acute myeloid leukemia: identification of isomer-specific antileukemic activities of the pregnadienedione structure. Molecular Cancer Therapeutics. 4: 1982-92. PMID 16373713 DOI: 10.1158/1535-7163.Mct-05-0247  0.551
2006 Abdelrahim M, Newman K, Vanderlaag K, Samudio I, Safe S. 3,3'-diindolylmethane (DIM) and its derivatives induce apoptosis in pancreatic cancer cells through endoplasmic reticulum stress-dependent upregulation of DR5. Carcinogenesis. 27: 717-28. PMID 16332727 DOI: 10.1093/Carcin/Bgi270  0.631
2005 Calabrò P, Samudio I, Safe SH, Willerson JT, Yeh ET. Inhibition of tumor-necrosis-factor-alpha induced endothelial cell activation by a new class of PPAR-gamma agonists. An in vitro study showing receptor-independent effects. Journal of Vascular Research. 42: 509-16. PMID 16155367 DOI: 10.1159/000088260  0.602
2005 Chintharlapalli S, Papineni S, Baek SJ, Liu S, Safe S. 1,1-Bis(3'-indolyl)-1-(p-substitutedphenyl)methanes are peroxisome proliferator-activated receptor gamma agonists but decrease HCT-116 colon cancer cell survival through receptor-independent activation of early growth response-1 and nonsteroidal anti-inflammatory drug-activated gene-1. Molecular Pharmacology. 68: 1782-92. PMID 16155208 DOI: 10.1124/Mol.105.017046  0.814
2005 Samudio I, Konopleva M, Hail N, Shi YX, McQueen T, Hsu T, Evans R, Honda T, Gribble GW, Sporn M, Gilbert HF, Safe S, Andreeff M. 2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) directly targets mitochondrial glutathione to induce apoptosis in pancreatic cancer. The Journal of Biological Chemistry. 280: 36273-82. PMID 16118208 DOI: 10.1074/Jbc.M507518200  0.603
2005 Vanderlaag K, Samudio I, Burghardt R, Barhoumi R, Safe S. Inhibition of breast cancer cell growth and induction of cell death by 1,1-bis(3'-indolyl)methane (DIM) and 5,5'-dibromoDIM. Cancer Letters. 236: 198-212. PMID 16051428 DOI: 10.1016/J.Canlet.2005.05.036  0.551
2005 Chintharlapalli S, Burghardt R, Papineni S, Ramaiah S, Yoon K, Safe S. Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathways. The Journal of Biological Chemistry. 280: 24903-14. PMID 15871945 DOI: 10.1074/Jbc.M500107200  0.816
2005 Contractor R, Samudio IJ, Estrov Z, Harris D, McCubrey JA, Safe SH, Andreeff M, Konopleva M. A novel ring-substituted diindolylmethane,1,1-bis[3'-(5-methoxyindolyl)]-1-(p-t-butylphenyl) methane, inhibits extracellular signal-regulated kinase activation and induces apoptosis in acute myelogenous leukemia. Cancer Research. 65: 2890-8. PMID 15805291 DOI: 10.1158/0008-5472.Can-04-3781  0.621
2005 Chintharlapalli S, Papineni S, Konopleva M, Andreef M, Samudio I, Safe S. 2-Cyano-3,12-dioxoolean-1,9-dien-28-oic acid and related compounds inhibit growth of colon cancer cells through peroxisome proliferator-activated receptor gamma-dependent and -independent pathways. Molecular Pharmacology. 68: 119-28. PMID 15798084 DOI: 10.1124/Mol.105.011437  0.827
2005 Kim K, Barhoumi R, Burghardt R, Safe S. Analysis of estrogen receptor alpha-Sp1 interactions in breast cancer cells by fluorescence resonance energy transfer. Molecular Endocrinology (Baltimore, Md.). 19: 843-54. PMID 15637147 DOI: 10.1210/Me.2004-0326  0.712
2005 Lee JE, Kim K, Sacchettini JC, Smith CV, Safe S. DRIP150 coactivation of estrogen receptor alpha in ZR-75 breast cancer cells is independent of LXXLL motifs. The Journal of Biological Chemistry. 280: 8819-30. PMID 15625066 DOI: 10.1074/Jbc.M413184200  0.697
2005 Samudio I, Konopleva M, Safe S, Andreeff M. Guggulsterones Induce Apoptosis and Differentiation in AML: Identification of Isomer-Specific Antileukemic Activities of the Pregnanedienedione Structure. Blood. 106: 4466-4466. DOI: 10.1182/Blood.V106.11.4466.4466  0.551
2005 Kassouf W, Safe S, Abdelrahim M, Chintharlapalli S, Nelkin GM, Kamat AM. 778: Activity of Novel Agonists of Peroxisome Proliferator-Activated Receptor Gamma (Ppargamma) Against Human Transitional Cell Tumors Journal of Urology. 173: 211-211. DOI: 10.1016/S0022-5347(18)34947-4  0.605
2004 Wu Q, Burghardt R, Safe S. Vitamin D-interacting protein 205 (DRIP205) coactivation of estrogen receptor alpha (ERalpha) involves multiple domains of both proteins. The Journal of Biological Chemistry. 279: 53602-12. PMID 15471764 DOI: 10.1074/Jbc.M409778200  0.423
2004 Chen CC, Lee WR, Safe S. Egr-1 is activated by 17beta-estradiol in MCF-7 cells by mitogen-activated protein kinase-dependent phosphorylation of ELK-1. Journal of Cellular Biochemistry. 93: 1063-74. PMID 15449318 DOI: 10.1002/Jcb.20257  0.822
2004 Hong J, Samudio I, Liu S, Abdelrahim M, Safe S. Peroxisome proliferator-activated receptor gamma-dependent activation of p21 in Panc-28 pancreatic cancer cells involves Sp1 and Sp4 proteins. Endocrinology. 145: 5774-85. PMID 15345676 DOI: 10.1210/En.2004-0686  0.551
2004 Chintharlapalli S, Smith R, Samudio I, Zhang W, Safe S. 1,1-Bis(3'-indolyl)-1-(p-substitutedphenyl)methanes induce peroxisome proliferator-activated receptor gamma-mediated growth inhibition, transactivation, and differentiation markers in colon cancer cells. Cancer Research. 64: 5994-6001. PMID 15342379 DOI: 10.1158/0008-5472.Can-04-0399  0.723
2004 Li X, Qin C, Burghardt R, Safe S. Hormonal regulation of lactate dehydrogenase-A through activation of protein kinase C pathways in MCF-7 breast cancer cells. Biochemical and Biophysical Research Communications. 320: 625-34. PMID 15240094 DOI: 10.1016/J.Bbrc.2004.05.205  0.721
2004 Qin C, Samudio I, Ngwenya S, Safe S. Estrogen-dependent regulation of ornithine decarboxylase in breast cancer cells through activation of nongenomic cAMP-dependent pathways. Molecular Carcinogenesis. 40: 160-70. PMID 15224348 DOI: 10.1002/Mc.20030  0.812
2004 Safe S, Kim K. Nuclear receptor-mediated transactivation through interaction with Sp proteins. Progress in Nucleic Acid Research and Molecular Biology. 77: 1-36. PMID 15196889 DOI: 10.1016/S0079-6603(04)77001-4  0.648
2004 Qin C, Morrow D, Stewart J, Spencer K, Porter W, Smith R, Phillips T, Abdelrahim M, Samudio I, Safe S. A new class of peroxisome proliferator-activated receptor gamma (PPARgamma) agonists that inhibit growth of breast cancer cells: 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes. Molecular Cancer Therapeutics. 3: 247-60. PMID 15026545  0.752
2004 Morrow D, Qin C, Smith R, Safe S. Aryl hydrocarbon receptor-mediated inhibition of LNCaP prostate cancer cell growth and hormone-induced transactivation. The Journal of Steroid Biochemistry and Molecular Biology. 88: 27-36. PMID 15026081 DOI: 10.1016/J.Jsbmb.2003.10.005  0.726
2004 Safe S, Wormke M, Samudio I. Mechanisms of inhibitory aryl hydrocarbon receptor-estrogen receptor crosstalk in human breast cancer cells. Journal of Mammary Gland Biology and Neoplasia. 5: 295-306. PMID 14973392 DOI: 10.1023/A:1009550912337  0.777
2004 Stoner M, Wormke M, Saville B, Samudio I, Qin C, Abdelrahim M, Safe S. Estrogen regulation of vascular endothelial growth factor gene expression in ZR-75 breast cancer cells through interaction of estrogen receptor alpha and SP proteins. Oncogene. 23: 1052-63. PMID 14647449 DOI: 10.1038/Sj.Onc.1207201  0.819
2004 Safe S, Wormke M. Inhibitory aryl hydrocarbon receptor-estrogen receptor alpha cross-talk and mechanisms of action. Chemical Research in Toxicology. 16: 807-16. PMID 12870882 DOI: 10.1021/Tx034036R  0.758
2004 Contractor R, Samudio IJ, Estrov Z, Harris D, McCubrey JA, Safe SH, Andreeff M, Konopleva M. A Novel Ring-Substituted Diindolylmethane 1,1-bis [3′-(5-methoxyindolyl)]-1-(p-t-butylphenyl) Methane Abrogates ERK Activation and Induces Apoptosis in Acute Myeloid Leukemia (AML). Blood. 104: 3399-3399. DOI: 10.1182/Blood.V104.11.3399.3399  0.551
2003 Zhang S, Qin C, Safe SH. Flavonoids as aryl hydrocarbon receptor agonists/antagonists: effects of structure and cell context. Environmental Health Perspectives. 111: 1877-82. PMID 14644660 DOI: 10.1289/Ehp.6322  0.743
2003 Khan S, Abdelrahim M, Samudio I, Safe S. Estrogen receptor/Sp1 complexes are required for induction of cad gene expression by 17beta-estradiol in breast cancer cells. Endocrinology. 144: 2325-35. PMID 12746293 DOI: 10.1210/En.2002-0149  0.683
2003 Ngwenya S, Safe S. Cell context-dependent differences in the induction of E2F-1 gene expression by 17 beta-estradiol in MCF-7 and ZR-75 cells. Endocrinology. 144: 1675-85. PMID 12697671 DOI: 10.1210/En.2002-0009  0.776
2003 Qin C, Burghardt R, Smith R, Wormke M, Stewart J, Safe S. Peroxisome proliferator-activated receptor gamma agonists induce proteasome-dependent degradation of cyclin D1 and estrogen receptor alpha in MCF-7 breast cancer cells. Cancer Research. 63: 958-64. PMID 12615709  0.723
2003 Wormke M, Stoner M, Saville B, Walker K, Abdelrahim M, Burghardt R, Safe S. The aryl hydrocarbon receptor mediates degradation of estrogen receptor α through activation of proteasomes Molecular and Cellular Biology. 23: 1843-1855. PMID 12612060 DOI: 10.1128/Mcb.23.6.1843-1855.2003  0.81
2003 Kim K, Thu N, Saville B, Safe S. Domains of estrogen receptor alpha (ERalpha) required for ERalpha/Sp1-mediated activation of GC-rich promoters by estrogens and antiestrogens in breast cancer cells. Molecular Endocrinology (Baltimore, Md.). 17: 804-17. PMID 12576490 DOI: 10.1210/Me.2002-0406  0.696
2003 Vyhlidal C, Li X, Safe S. Estrogen regulation of transferrin gene expression in MCF-7 human breast cancer cells. Journal of Molecular Endocrinology. 29: 305-17. PMID 12459033 DOI: 10.1677/Jme.0.0290305  0.663
2003 Zhang W, Jiang J, Qin C, Pérez LM, Parrish AR, Safe SH, Simanek EE. Triazine Dendrimers for Drug Delivery: Evaluation of Solubilization Properties, Activity in Cell Culture, and In Vivo Toxicity of a Candidate Vehicle Supramolecular Chemistry. 15: 607-616. DOI: 10.1080/10610270310001605197  0.679
2002 Stoner M, Saville B, Wormke M, Dean D, Burghardt R, Safe S. Hypoxia induces proteasome-dependent degradation of estrogen receptor α in ZR-75 breast cancer cells Molecular Endocrinology. 16: 2231-2242. PMID 12351689 DOI: 10.1210/Me.2001-0347  0.812
2002 Qin C, Nguyen T, Stewart J, Samudio I, Burghardt R, Safe S. Estrogen up-regulation of p53 gene expression in MCF-7 breast cancer cells is mediated by calmodulin kinase IV-dependent activation of a nuclear factor kappaB/CCAAT-binding transcription factor-1 complex. Molecular Endocrinology (Baltimore, Md.). 16: 1793-809. PMID 12145335 DOI: 10.1210/Me.2002-0006  0.785
2002 Abdelrahim M, Samudio I, Smith R, Burghardt R, Safe S. Small inhibitory RNA duplexes for Sp1 mRNA block basal and estrogen-induced gene expression and cell cycle progression in MCF-7 breast cancer cells. The Journal of Biological Chemistry. 277: 28815-22. PMID 12052832 DOI: 10.1074/Jbc.M203828200  0.551
2002 Duan R, Xie W, Li X, McDougal A, Safe S. Estrogen regulation of c-fos gene expression through phosphatidylinositol-3-kinase-dependent activation of serum response factor in MCF-7 breast cancer cells. Biochemical and Biophysical Research Communications. 294: 384-94. PMID 12051724 DOI: 10.1016/S0006-291X(02)00499-0  0.796
2002 Safe S, McDougal A. Mechanism of action and development of selective aryl hydrocarbon receptor modulators for treatment of hormone-dependent cancers (Review). International Journal of Oncology. 20: 1123-8. PMID 12011988 DOI: 10.3892/Ijo.20.6.1123  0.808
2002 Wang F, Samudio I, Safe S. Transcriptional activation of rat creatine kinase B by 17beta-estradiol in MCF-7 cells involves an estrogen responsive element and GC-rich sites. Journal of Cellular Biochemistry. 84: 156-72. PMID 11746525 DOI: 10.1002/Jcb.1276  0.551
2002 Saville B, Poukka H, Wormke M, Jänne OA, Palvimo JJ, Stoner M, Samudio I, Safe S. Cooperative coactivation of estrogen receptor α in ZR-75 human breast cancer cells by SNURF and TATA-binding protein Journal of Biological Chemistry. 277: 2485-2497. PMID 11696545 DOI: 10.1074/Jbc.M109021200  0.795
2001 Samudio I, Vyhlidal C, Wang F, Stoner M, Chen I, Kladde M, Barhoumi R, Burghardt R, Safe S. Transcriptional Activation of Deoxyribonucleic Acid Polymerase α Gene Expression in MCF-7 Cells by 17β-Estradiol. Endocrinology. 142: 1000-1008. PMID 28201425 DOI: 10.1210/Endo.142.3.8022  0.808
2001 Stewart DM, Johnson GA, Vyhlidal CA, Burghardt RC, Safe SH, Yu-Lee LY, Bazer FW, Spencer TE. Interferon-τ Activates Multiple Signal Transducer and Activator of Transcription Proteins and Has Complex Effects on Interferon-Responsive Gene Transcription in Ovine Endometrial Epithelial Cells* * This work was supported by NIH Grant HD-32534 (to F.W.B. and T.E.S.) and in part by NIH Grant P30-ES-09106. The publication costs of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact. Endocrinology. 142: 98-107. PMID 28201367 DOI: 10.1210/endo.142.1.7891  0.663
2001 Lee JE, Safe S. Involvement of a post-transcriptional mechanism in the inhibition of CYP1A1 expression by resveratrol in breast cancer cells Biochemical Pharmacology. 62: 1113-1124. PMID 11597580 DOI: 10.1016/S0006-2952(01)00763-8  0.301
2001 Yoon K, Pallaroni L, Stoner M, Gaido K, Safe S. Differential activation of wild-type and variant forms of estrogen receptor α by synthetic and natural estrogenic compounds using a promoter containing three estrogen-responsive elements Journal of Steroid Biochemistry and Molecular Biology. 78: 25-32. PMID 11530281 DOI: 10.1016/S0960-0760(01)00070-X  0.753
2001 McDougal A, Gupta MS, Morrow D, Ramamoorthy K, Lee JE, Safe SH. Methyl-substituted diindolylmethanes as inhibitors of estrogen-induced growth of T47D cells and mammary tumors in rats. Breast Cancer Research and Treatment. 66: 147-57. PMID 11437101 DOI: 10.1023/A:1010608000074  0.806
2001 Castro-Rivera E, Samudio I, Safe S. Estrogen regulation of cyclin D1 gene expression in ZR-75 breast cancer cells involves multiple enhancer elements. The Journal of Biological Chemistry. 276: 30853-61. PMID 11410592 DOI: 10.1074/Jbc.M103339200  0.642
2001 Xie W, Duan R, Safe S. Activation of adenosine deaminase in MCF-7 cells through IGF-estrogen receptor alpha crosstalk. Journal of Molecular Endocrinology. 26: 217-28. PMID 11357058 DOI: 10.1677/Jme.0.0260217  0.533
2001 Qin C, Wilson C, Blancher C, Taylor M, Safe S, Harris AL. Association of ARNT splice variants with estrogen receptor-negative breast cancer, poor induction of vascular endothelial growth factor under hypoxia, and poor prognosis. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 7: 818-23. PMID 11309328  0.717
2001 Porter W, Wang F, Duan R, Qin C, Castro-Rivera E, Kim K, Safe S. Transcriptional activation of heat shock protein 27 gene expression by 17beta-estradiol and modulation by antiestrogens and aryl hydrocarbon receptor agonists. Journal of Molecular Endocrinology. 26: 31-42. PMID 11174852 DOI: 10.1677/Jme.0.0260031  0.829
2001 Wang F, Samudio I, Safe S. Transcriptional activation of cathepsin D gene expression by 17beta-estradiol: mechanism of aryl hydrocarbon receptor-mediated inhibition. Molecular and Cellular Endocrinology. 172: 91-103. PMID 11165043 DOI: 10.1016/S0303-7207(00)00379-8  0.551
2001 Duan R, Xie W, Burghardt RC, Safe S. Estrogen receptor-mediated activation of the serum response element in MCF-7 cells through MAPK-dependent phosphorylation of Elk-1. The Journal of Biological Chemistry. 276: 11590-8. PMID 11145955 DOI: 10.1074/Jbc.M005492200  0.53
2001 Stewart MD, Stewart DM, Johnson GA, Vyhlidal CA, Burghardt RC, Safe SH, Yu-Lee LY, Bazer FW, Spencer TE. Interferon-tau activates multiple signal transducer and activator of transcription proteins and has complex effects on interferon-responsive gene transcription in ovine endometrial epithelial cells. Endocrinology. 142: 98-107. PMID 11145571 DOI: 10.1210/Endo.142.1.7891  0.706
2000 Xie W, Duan R, Chen I, Samudio I, Safe S. Transcriptional Activation of Thymidylate Synthase by 17β-Estradiol in MCF-7 Human Breast Cancer Cells. Endocrinology. 141: 2439-2449. PMID 28201107 DOI: 10.1210/endo.141.7.7538  0.407
2000 Xie W, Barwick JL, Simon CM, Pierce AM, Safe S, Blumberg B, Guzelian PS, Evans RM. Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR. Genes & Development. 14: 3014-23. PMID 11114890 DOI: 10.1101/Gad.846800  0.469
2000 Lee JE, Safe S. 3′, 4′-Dimethoxyflavone as an aryl hydrocarbon receptor antagonist in human breast cancer cells Toxicological Sciences. 58: 235-242. PMID 11099636 DOI: 10.1093/Toxsci/58.2.235  0.335
2000 Wormke M, Stoner M, Saville B, Safe S. Crosstalk between estrogen receptor alpha and the aryl hydrocarbon receptor in breast cancer cells involves unidirectional activation of proteasomes. Febs Letters. 478: 109-12. PMID 10922479 DOI: 10.1016/S0014-5793(00)01830-5  0.777
2000 Xie W, Duan R, Chen I, Samudio I, Safe S. Transcriptional activation of thymidylate synthase by 17beta-estradiol in MCF-7 human breast cancer cells. Endocrinology. 141: 2439-49. PMID 10875244 DOI: 10.1210/Endo.141.7.7538  0.706
2000 Vyhlidal C, Samudio I, Kladde MP, Safe S. Transcriptional activation of transforming growth factor alpha by estradiol: requirement for both a GC-rich site and an estrogen response element half-site. Journal of Molecular Endocrinology. 24: 329-38. PMID 10828826 DOI: 10.1677/Jme.0.0240329  0.753
2000 Wormke M, Castro-Rivera E, Chen I, Safe S. Estrogen and aryl hydrocarbon receptor expression and crosstalk in human Ishikawa endometrial cancer cells. The Journal of Steroid Biochemistry and Molecular Biology. 72: 197-207. PMID 10822009 DOI: 10.1016/S0960-0760(00)00030-3  0.814
2000 Stoner M, Wang F, Wormke M, Nguyen T, Samudio I, Vyhlidal C, Marme D, Finkenzeller G, Safe S. Inhibition of vascular endothelial growth factor expression in HEC1A endometrial cancer cells through interactions of estrogen receptor alpha and Sp3 proteins. The Journal of Biological Chemistry. 275: 22769-79. PMID 10816575 DOI: 10.1074/Jbc.M002188200  0.775
2000 McDougal A, Sethi Gupta M, Ramamoorthy K, Sun G, Safe SH. Inhibition of carcinogen-induced rat mammary tumor growth and other estrogen-dependent responses by symmetrical dihalo-substituted analogs of diindolylmethane. Cancer Letters. 151: 169-79. PMID 10738111 DOI: 10.1016/S0304-3835(99)00406-1  0.814
2000 Saville B, Wormke M, Wang F, Nguyen T, Enmark E, Kuiper G, Gustafsson J, Safe S. Ligand-, Cell-, and Estrogen Receptor Subtype (α/β)-dependent Activation at GC-rich (Sp1) Promoter Elements Journal of Biological Chemistry. 275: 5379-5387. PMID 10681512 DOI: 10.1074/Jbc.275.8.5379  0.794
1999 Qin C, Singh P, Safe S. Transcriptional Activation of Insulin-Like Growth Factor-Binding Protein-4 by 17β-Estradiol in MCF-7 Cells: Role of Estrogen Receptor-Sp1 Complexes. Endocrinology. 140: 2501-2508. PMID 28200910 DOI: 10.1210/endo.140.6.6751  0.672
1999 Xie W, Duan R, Safe S. Estrogen Induces Adenosine Deaminase Gene Expression in MCF-7 Human Breast Cancer Cells: Role of Estrogen Receptor-Sp1 Interactions* *This work was supported by the National Institutes of Health (Grant CA-76636), the Welch Foundation, and the Texas Agricultural Experiment Station. Endocrinology. 140: 219-227. PMID 28200731 DOI: 10.1210/endo.140.1.6394  0.407
1999 Safe S, Qin C, McDougal A. Development of selective aryl hydrocarbon receptor modulators for treatment of breast cancer. Expert Opinion On Investigational Drugs. 8: 1385-96. PMID 15992156 DOI: 10.1517/13543784.8.9.1385  0.823
1999 Dong L, Wang W, Wang F, Stoner M, Reed JC, Harigai M, Samudio I, Kladde MP, Vyhlidal C, Safe S. Mechanisms of transcriptional activation of bcl-2 gene expression by 17beta-estradiol in breast cancer cells. The Journal of Biological Chemistry. 274: 32099-107. PMID 10542244 DOI: 10.1074/Jbc.274.45.32099  0.778
1999 Duan R, Porter W, Samudio I, Vyhlidal C, Kladde M, Safe S. Transcriptional activation of c-fos protooncogene by 17beta-estradiol: mechanism of aryl hydrocarbon receptor-mediated inhibition. Molecular Endocrinology (Baltimore, Md.). 13: 1511-21. PMID 10478842 DOI: 10.1210/Mend.13.9.0338  0.753
1999 Castro-Rivera E, Wormke M, Safe S. Estrogen and aryl hydrocarbon responsiveness of ECC-1 endometrial cancer cells. Molecular and Cellular Endocrinology. 150: 11-21. PMID 10411295 DOI: 10.1016/S0303-7207(99)00041-6  0.806
1999 Qin C, Singh P, Safe S. Transcriptional activation of insulin-like growth factor-binding protein-4 by 17beta-estradiol in MCF-7 cells: role of estrogen receptor-Sp1 complexes. Endocrinology. 140: 2501-8. PMID 10342835 DOI: 10.1210/Endo.140.6.6751  0.732
1999 Ramamoorthy K, Gupta MS, Sun G, McDougal A, Safe SH. 3,3'4,4'-Tetrachlorobiphenyl exhibits antiestrogenic and antitumorigenic activity in the rodent uterus and mammary cells and in human breast cancer cells. Carcinogenesis. 20: 115-23. PMID 9934858 DOI: 10.1093/Carcin/20.1.115  0.825
1999 Xie W, Duan R, Safe S. Estrogen induces adenosine deaminase gene expression in MCF-7 human breast cancer cells: role of estrogen receptor-Sp1 interactions. Endocrinology. 140: 219-27. PMID 9886828 DOI: 10.1210/Endo.140.1.6394  0.501
1998 Gupta M, McDougal A, Safe S. Estrogenic and antiestrogenic activities of 16alpha- and 2-hydroxy metabolites of 17beta-estradiol in MCF-7 and T47D human breast cancer cells. The Journal of Steroid Biochemistry and Molecular Biology. 67: 413-9. PMID 10030690 DOI: 10.1016/S0960-0760(98)00135-6  0.798
1998 Safe S, Wang F, Porter W, Duan R, McDougal A. Ah receptor agonists as endocrine disruptors: antiestrogenic activity and mechanisms. Toxicology Letters. 102: 343-7. PMID 10022276 DOI: 10.1016/S0378-4274(98)00331-2  0.809
1998 Chen I, McDougal A, Wang F, Safe S. Aryl hydrocarbon receptor-mediated antiestrogenic and antitumorigenic activity of diindolylmethane. Carcinogenesis. 19: 1631-9. PMID 9771935 DOI: 10.1093/Carcin/19.9.1631  0.815
1998 Sun G, Porter W, Safe S. Estrogen-induced retinoic acid receptor alpha 1 gene expression: role of estrogen receptor-Sp1 complex. Molecular Endocrinology (Baltimore, Md.). 12: 882-90. PMID 9626663 DOI: 10.1210/Mend.12.6.0125  0.533
1998 McDougal A, Safe S. Induction of 16alpha-/2-hydroxyestrone metabolite ratios in MCF-7 cells by pesticides, carcinogens, and antiestrogens does not predict mammary carcinogens. Environmental Health Perspectives. 106: 203-6. PMID 9494123 DOI: 10.1289/Ehp.98106203  0.779
1997 McDougal A, Wilson C, Safe S. Induction of estradiol 2-hydroxylase activity in MCF-7 human breast cancer cells by pesticides and carcinogens. Environmental Toxicology and Pharmacology. 3: 195-9. PMID 21781778 DOI: 10.1016/S1382-6689(97)00013-6  0.798
1997 McDougal A, Wilson C, Safe S. Inhibition of 7,12-dimethylbenz[a]anthracene-induced rat mammary tumor growth by aryl hydrocarbon receptor agonists. Cancer Letters. 120: 53-63. PMID 9570386 DOI: 10.1016/S0304-3835(97)00299-1  0.79
1997 Hoivik D, Willett K, Wilson C, Safe S. Estrogen does not inhibit 2,3,7,8-tetrachlorodibenzo-p-dioxinmediated effects in MCF-7 and Hepa 1c1c7 cells Journal of Biological Chemistry. 272: 30270-30274. PMID 9374512 DOI: 10.1074/Jbc.272.48.30270  0.309
1997 Fielden MR, Chen I, Chittim B, Safe SH, Zacharewski TR. Examination of the estrogenicity of 2,4,6,2',6'-pentachlorobiphenyl (PCB 104), its hydroxylated metabolite 2,4,6,2',6'-pentachloro-4-biphenylol (HO-PCB 104), and a further chlorinated derivative, 2,4,6,2',4',6'-hexachlorobiphenyl (PCB 155). Environmental Health Perspectives. 105: 1238-48. PMID 9370515  0.769
1997 Ramamoorthy K, Vyhlidal C, Wang F, Chen I, Safe S, McDonnell DP, Leonard LS, Gaido KW. Additive estrogenic activities of a binary mixture of 2',4',6'-trichloro- and 2',3',4',5'-tetrachloro-4-biphenylol. Toxicology and Applied Pharmacology. 147: 93-100. PMID 9356311 DOI: 10.1006/Taap.1997.8281  0.663
1997 Wilson CL, Thomsen J, Hoivik DJ, Wormke MT, Stanker L, Holtzapple C, Safe SH. Aryl hydrocarbon (Ah) nonresponsiveness in estrogen receptor-negative MDA-MB-231 cells is associated with expression of a variant arnt protein. Archives of Biochemistry and Biophysics. 346: 65-73. PMID 9328285 DOI: 10.1006/Abbi.1997.0289  0.812
1997 Sun G, Safe S. Antiestrogenic activities of alternate-substituted polychlorinated dibenzofurans in MCF-7 human breast cancer cells. Cancer Chemotherapy and Pharmacology. 40: 239-44. PMID 9219508 DOI: 10.1007/S002800050653  0.546
1997 Gillesby BE, Stanostefano M, Porter W, Safe S, Wu ZF, Zacharewski TR. Identification of a motif within the 5' regulatory region of pS2 which is responsible for AP-1 binding and TCDD-mediated suppression Biochemistry. 36: 6080-6089. PMID 9166778 DOI: 10.1021/Bi962131B  0.619
1997 Nodland KI, Wormke M, Safe S. Inhibition of estrogen-induced activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the MCF-7 human breast cancer and other cell lines transfected with vitellogenin A2 gene promoter constructs. Archives of Biochemistry and Biophysics. 338: 67-72. PMID 9015389 DOI: 10.1006/Abbi.1996.9806  0.758
1997 Fielden MR, Chen I, Chittim B, Safe SH, Zacharewski TR. Examination of the Estrogenicity of 2,4,6,2 prime ,6 prime -Pentachlorobiphenyl (PCB 104), Its Hydroxylated Metabolite 2,4,6,2 prime ,6 prime -Pentachloro-4-Biphenylol (HO-PCB 104), and a Further Chlorinated Derivative, 2,4,6,2 prime ,4 prime ,6 prime -Hexachlorobiphenyl (PCB 155) Environmental Health Perspectives. 105: 1238. DOI: 10.2307/3433904  0.719
1997 Safe SH, McDougal A. Environmental factors and breast cancer Endocrine Related Cancer. 4: 113-123. DOI: 10.1677/Erc.0.0040113  0.752
1996 Lu YF, Sun G, Wang X, Safe S. Inhibition of prolactin receptor gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin in MCF-7 human breast cancer cells. Archives of Biochemistry and Biophysics. 332: 35-40. PMID 8806706 DOI: 10.1006/Abbi.1996.0313  0.549
1995 Xiaohong Wang, Thomsen JS, Santostefano M, Rosengren R, Safe S, Perdew GH. Comparative properties of the nuclear aryl hydrocarbon (Ah) receptor complex from several human cell lines European Journal of Pharmacology: Environmental Toxicology And. 293: 191-205. PMID 8666036 DOI: 10.1016/0926-6917(95)00017-8  0.306
1995 Safe S, Krishnan V. Chlorinated hydrocarbons: estrogens and antiestrogens Toxicology Letters. 82: 731-736. PMID 8597135 DOI: 10.1016/0378-4274(95)03591-5  0.319
1995 Safe S, Krishnan V. Cellular and molecular biology of aryl hydrocarbon (Ah) receptor-mediated gene expression Archives of Toxicology. Supplement. Archiv Fur Toxikologie. Supplement. 17: 99-115. PMID 7786196 DOI: 10.1007/978-3-642-79451-3_8  0.314
1994 Liu H, Wormke M, Safe SH, Bjeldanes LF. Indolo[3,2-b]carbazole: a dietary-derived factor that exhibits both antiestrogenic and estrogenic activity. Journal of the National Cancer Institute. 86: 1758-65. PMID 7966413 DOI: 10.1093/Jnci/86.23.1758  0.758
1993 Moore M, Narasimhan TR, Steinberg MA, Wang X, Safe S. Potentiation of CYP1A1 gene expression in MCF-7 human breast cancer cells cotreated with 2,3,7,8-tetrachlorodibenzo-p-dioxin and 12-O-tetradecanoylphorbol-13-acetate. Archives of Biochemistry and Biophysics. 305: 483-8. PMID 8396892 DOI: 10.1006/Abbi.1993.1451  0.3
1993 Arellano LO, Wang X, Safe S. Effects of cycloheximide on the induction of CYP1A1 gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in three human breast cancer cell lines. Carcinogenesis. 14: 219-22. PMID 8382112 DOI: 10.1093/Carcin/14.2.219  0.31
1992 Safe S, Biegel L, Harris M, Narasimhan TR, Lui H, Fernandez P. Inhibition of estrogen- and growth factor-induced proliferation of human breast cancer cell lines by TCDD: characterization and mechanistic studies Chemosphere. 25: 83-86. DOI: 10.1016/0045-6535(92)90485-A  0.301
1992 Liu H, Chinnah A, Kemp M, Safe S. Possible interrelationship between TCDD and interleukin-1 as antiproliferative agents in human breast cancer cells Chemosphere. 25: 951-954. DOI: 10.1016/0045-6535(92)90090-E  0.321
1991 Safe S, Astroff B, Harris M, Zacharewski T, Dickerson R, Romkes M, Biegel L. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds as antioestrogens: characterization and mechanism of action. Pharmacology & Toxicology. 69: 400-9. PMID 1766914 DOI: 10.1111/J.1600-0773.1991.Tb01321.X  0.341
1990 Bunce NJ, Landers JP, Schneider UA, Safe SH, Zacharewski TR. Chlorinated trans stilbenes: Competitive binding to the ah receptor, induction of cytochrome p-450 monooxygenase activity and partial 2, 3, 7, 8-TCDD antagonism Toxicological & Environmental Chemistry. 28: 217-229. DOI: 10.1080/02772249009357605  0.585
1989 Harris M, Piskorska-Pliszczynska J, Zacharewski T, Romkes M, Safe S. Structure-dependent induction of aryl hydrocarbon hydroxylase in human breast cancer cell lines and characterization of the Ah receptor. Cancer Research. 49: 4531-5. PMID 2545344  0.313
1988 Parkinson A, Thomas PE, Ryan DE, Levin W, Fujita T, Safe S. Induction of rat liver microsomal cytochrome P-450 isozymes and epoxide hydrolase by a series of 4'-substituted-2,3,4,5-tetrachlorobiphenyls. Toxicology. 53: 289-300. PMID 3145631 DOI: 10.1016/0300-483X(88)90221-1  0.563
1988 Halvorson MR, Safe SH, Parkinson A, Phillips TD. Aflatoxin B1 hydroxylation by the pregnenolone-16 alpha-carbonitrile-inducible form of rat liver microsomal cytochrome P-450. Carcinogenesis. 9: 2103-8. PMID 3141079 DOI: 10.1093/carcin/9.11.2103  0.512
1988 Astroff B, Zacharewski T, Safe S, Arlotto MP, Parkinson A, Thomas P, Levin W. 6-Methyl-1,3,8-trichlorodibenzofuran as a 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonist: inhibition of the induction of rat cytochrome P-450 isozymes and related monooxygenase activities. Molecular Pharmacology. 33: 231-6. PMID 2828916  0.581
1985 Shepherd EC, Phillips TD, Irvin TR, Safe SH, Robertson LW. Aflatoxin B1 metabolism in the rat: polyhalogenated biphenyl enhanced conversion to aflatoxin M1. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 14: 741-50. PMID 6097059 DOI: 10.3109/00498258409151472  0.44
1985 Halvorson MR, Phillips TD, Safe SH, Robertson LW. Metabolism of aflatoxin B1 by rat hepatic microsomes induced by polyhalogenated biphenyl congeners. Applied and Environmental Microbiology. 49: 882-6. PMID 2988440 DOI: 10.1128/Aem.49.4.882-886.1985  0.44
1985 Safe S, Bandiera S, Sawyer T, Robertson L, Safe L, Parkinson A, Thomas PE, Ryan DE, Reik LM, Levin W, Denomme MA, Fujita T. PCBs: Structure-Function Relationships and Mechanism of Action Environmental Health Perspectives. 60: 47. DOI: 10.2307/3429944  0.644
1984 Robertson LW, Parkinson A, Bandiera S, Lambert I, Merrill J, Safe SH. PCBs and PBBs: biologic and toxic effects on C57BL/6J and DBA/2J inbred mice. Toxicology. 31: 191-206. PMID 6330936 DOI: 10.1016/0300-483x(84)90101-x  0.659
1984 Robertson LW, Safe SH, Parkinson A, Pellizzari E, Pochini C, Mullin MD. Synthesis and identification of highly toxic polybrominated biphenyls in the fire retardant Firemaster BP-6 Journal of Agricultural and Food Chemistry. 32: 1107-1111. DOI: 10.1021/Jf00125A045  0.629
1983 Parkinson A, Robertson LW, Safe S. Binding of metyrapone to dithionite-reduced cytochrome P-450 from rats treated with xenobiotics. Biochemical Pharmacology. 31: 3489-94. PMID 7150369 DOI: 10.1016/0006-2952(82)90631-1  0.629
1983 Campbell MA, Bandiera S, Robertson L, Parkinson A, Safe S. Hepta-, hexa-, tetra- and dichloronaphthalene congeners as inducers of hepatic microsomal drug-metabolizing enzymes. Toxicology. 26: 193-205. PMID 6857695 DOI: 10.1016/0300-483X(83)90081-1  0.673
1983 Parkinson A, Thomas PE, Ryan DE, Reik LM, Safe SH, Robertson LW, Levin W. Differential time course of induction of rat liver microsomal cytochrome P-450 isozymes and epoxide hydrolase by Aroclor 1254. Archives of Biochemistry and Biophysics. 225: 203-15. PMID 6412631 DOI: 10.1016/0003-9861(83)90024-3  0.629
1983 Parkinson A, Robertson LW, Safe SH. Induction of rat hepatic microsomal cytochrome P-450 by 2,3',4,4',5,5'-hexachlorobiphenyl. Biochemical Pharmacology. 32: 2269-79. PMID 6409119 DOI: 10.1016/0006-2952(83)90237-X  0.629
1983 Andres J, Lambert I, Robertson L, Bandiera S, Sawyer T, Lovering S, Safe S. The comparative biologic and toxic potencies of polychlorinated biphenyls and polybrominated biphenyls. Toxicology and Applied Pharmacology. 70: 204-15. PMID 6312630 DOI: 10.1016/0041-008X(83)90096-0  0.44
1983 Robertson LW, Andres JL, Safe SH, Lovering SL. Toxicity of 3,3',4,4'- and 2,2',5,5'-tetrabromobiphenyl: correlation of activity with aryl hydrocarbon hydroxylase induction and lack of protection by antioxidants. Journal of Toxicology and Environmental Health. 11: 81-91. PMID 6298436 DOI: 10.1080/15287398309530322  0.44
1983 Robertson LW, Parkinson A, Campbell MA, Safe S. Polybrominated biphenyls as aryl hydrocarbon hydroxylase inducers: structure-activity correlations. Chemico-Biological Interactions. 42: 53-66. PMID 6295646 DOI: 10.1016/0009-2797(82)90141-7  0.629
1983 Robertson LW, Chittim B, Safe SH, Mullin MD, Pochini CM. Photodecomposition of a commercial polybrominated biphenyl (PBB) fire retardant: high-resolution gas chromatographic analysis Journal of Agricultural and Food Chemistry. 31: 454-457. DOI: 10.1021/Jf00116A071  0.44
1982 Parkinson A, Robertson LW, Safe S. Further characterization and applications of the 4-chlorobiphenyl hydroxylase assay. Advances in Experimental Medicine and Biology. 753-9. PMID 7344491 DOI: 10.1007/978-1-4757-0674-1_57  0.653
1982 Parkinson A, Safe S. The cytochrome P-450-mediated metabolism of biphenyl and the 4-halobiphenyls. Advances in Experimental Medicine and Biology. 745-52. PMID 7344490 DOI: 10.1007/978-1-4757-0674-1_56  0.512
1982 Bandiera S, Sawyer T, Campbell MA, Robertson L, Safe S. Halogenated biphenyls as AHH inducers: effects of different halogen substituents. Life Sciences. 31: 517-25. PMID 7132565 DOI: 10.1016/0024-3205(82)90479-9  0.44
1982 Parkinson A, Safe S. Cytochrome P-450-mediated metabolism of biphenyl and the 4-halobiphenyls. Biochemical Pharmacology. 31: 1849-56. PMID 7104016 DOI: 10.1016/0006-2952(82)90487-7  0.512
1982 Parkinson A, Robertson L, Uhlig L, Campbell MA, Safe S. 2,3,4,4'-Pentachlorobiphenyl: differential effects on C57BL/6J and DBA/2J inbred mice. Biochemical Pharmacology. 31: 2830-3. PMID 6814446 DOI: 10.1016/0006-2952(82)90143-5  0.629
1982 Safe S, Robertson LW, Safe L, Parkinson A, Bandiera S, Sawyer T, Campbell MA. Halogenated biphenyls: molecular toxicology. Canadian Journal of Physiology and Pharmacology. 60: 1057-64. PMID 6812934 DOI: 10.1139/Y82-151  0.682
1981 Parkinson A, Copp L, Safe S. The utility of the microsomal 4-chlorobiphenyl hydroxylase enzyme assay in distinguishing between phenobarbitone- and 3-methylcholanthrene-induced microsomal monooxygenases. Analytical Biochemistry. 105: 65-73. PMID 7446991 DOI: 10.1016/0003-2697(80)90424-8  0.56
1981 Campbell MA, Bandiera S, Robertson L, Parkinson A, Safe S. Octachloronaphthalene induction of hepatic microsomal aryl hydrocarbon hydroxylase activity in the immature male rat. Toxicology. 22: 123-32. PMID 7324072 DOI: 10.1016/0300-483X(81)90112-8  0.661
1981 Parkinson A, Robertson LW, Safe S. Hepatic microsomal enzyme induction by 2,2', 3,3', 4,4'- and 2,2', 3', 4,4', 5-hexachlorobiphenyl. Life Sciences. 27: 2333-7. PMID 6782406 DOI: 10.1016/0024-3205(80)90502-0  0.652
1981 Parkinson A, Robertson LW, Safe L, Safe S. Polychlorinated biphenyls as inducers of hepatic microsomal enzymes: effects of di-ortho substitution. Chemico-Biological Interactions. 35: 1-12. PMID 6781768 DOI: 10.1016/0009-2797(81)90059-4  0.629
1981 Robertson LW, Parkinson A, Chittim B, Bandiera S, Sawyer TW, Safe S. Aryl hydrocarbon hydroxylase (AHH) induction by polybrominated biphenyls (PBBs): enchancement by photolysis. Toxicology. 22: 103-14. PMID 6275573 DOI: 10.1016/0300-483X(81)90110-4  0.666
1981 Robertson L, Parkinson A, Safe S. Induction of drug-metabolizing enzymes by fractionated commercial polybrominated biphenyls (PBBs). Toxicology and Applied Pharmacology. 57: 254-62. PMID 6261418 DOI: 10.1016/0041-008X(81)90287-8  0.66
1981 Robertson LW, Parkinson A, Bandiera S, Safe S. Potent induction of rat liver microsomal, drug-metabolizing enzymes by 2,3,3',4,4',5-hexabromobiphenyl, a component of fireMaster. Chemico-Biological Interactions. 35: 13-24. PMID 6258818 DOI: 10.1016/0009-2797(81)90060-0  0.629
1981 Safe S, Robertson L, Safe L, Parkinson A, Campbell M, Sawyer T, Bandiera S. POLYCHLORINATED BIPHENYLS (PCBs) AS INDUCERS OF THE HEPATIC MICROSOMAL DRUG-METABOLIZING ENZYMES - EFFECTS OF STRUCTURE ON ACTIVITY Drug Metabolism and Drug Interactions. 3. DOI: 10.1515/Dmdi.1981.3.4.255  0.629
1981 Parkinson A, Safe S. Aryl hydrocarbon hydroxylase induction and its relationship to the toxicity of halogenated aryl hydrocarbons Toxicological & Environmental Chemistry. 4: 1-46. DOI: 10.1080/02772248109356957  0.512
1980 Parkinson A, Robertson LW, Safe S. Reconstituted human breast milk PCBs as potent inducers of aryl hydrocarbon hydroxylase. Biochemical and Biophysical Research Communications. 96: 882-9. PMID 6775632 DOI: 10.1016/0006-291X(80)91438-2  0.67
1980 Parkinson A, Robertson L, Safe L, Safe S. Polychlorinated biphenyls as inducers of hepatic microsomal enzymes: structure-activity rules. Chemico-Biological Interactions. 30: 271-85. PMID 6769597 DOI: 10.1016/0009-2797(80)90050-2  0.629
1980 Parkinson A, Cockerline R, Safe S. Induction of both 3-methylcholanthrene- and phenobarbitone-type microsomal enzyme activity by a single polychlorinated biphenyl isomer. Biochemical Pharmacology. 29: 259-62. PMID 6767483 DOI: 10.1016/0006-2952(80)90339-1  0.512
1980 Parkinson A, Cockerline R, Safe S. Polychlorinated biphenyl isomers and congeners as inducers of both 3-methylcholanthrene- and phenobarbitone-type microsomal enzyme activity. Chemico-Biological Interactions. 29: 277-89. PMID 6766814 DOI: 10.1016/0009-2797(80)90147-7  0.512
1980 Robertson LW, Parkinson A, Safe S. Induction of both cytochromes P-450 and P-448 by 2,3',4,4',5-pentabromobiphenyl, a component of fireMaster. Biochemical and Biophysical Research Communications. 92: 175-82. PMID 6243934 DOI: 10.1016/0006-291X(80)91536-3  0.667
1980 Parkinson A, Copp L, Safe S. 4-Chlorobiphenyl Hydroxylase: A Monooxygenase Preferentially Induced By 3-Methylcholanthrene Microsomes, Drug Oxidations and Chemical Carcinogenesis. 977-980. DOI: 10.1016/B978-0-12-187702-6.50077-3  0.537
1980 Parkinson A, Cockerline R, Robertson L, Safe S. Induction Of Cytochrome P-448 And P-450 By Pcb Isomers And Congeners Microsomes, Drug Oxidations and Chemical Carcinogenesis. 579-582. DOI: 10.1016/B978-0-12-187701-9.50113-3  0.57
1979 Parkinson A, Safe S. The detection of enzyme induction by rat liver microsomes prepared by isoelectric precipitation. The Journal of Pharmacy and Pharmacology. 31: 444-7. PMID 38312 DOI: 10.1111/J.2042-7158.1979.Tb13550.X  0.512
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