Lester F. Lau, PhD - Publications

Affiliations: 
1983-1986 Molecular Biology and Genetics Johns Hopkins University of School of Medicine 
 1986-1989 Molecular Biology Northwestern University, Evanston, IL 
 1989- Biochemistry and Molecular Genetics University of Illinois at Chicago, Health Sciences Center, Chicago, IL 60612, United States 
Area:
Cell Biology, Genetics, Biochemistry
Website:
https://bcmg.com.uic.edu/faculty/lau_lester.html

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Year Citation  Score
2022 Cheng N, Kim KH, Lau LF. Analysis of CCN Functions in Liver Regeneration After Partial Hepatectomy. Methods in Molecular Biology (Clifton, N.J.). 2582: 209-221. PMID 36370352 DOI: 10.1007/978-1-0716-2744-0_14  0.767
2022 Kim KH, Cheng N, Lau LF. Cellular communication network factor 1-stimulated liver macrophage efferocytosis drives hepatic stellate cell activation and liver fibrosis. Hepatology Communications. PMID 35929736 DOI: 10.1002/hep4.2057  0.804
2022 Cheng N, Kim KH, Lau LF. Senescent hepatic stellate cells promote liver regeneration through IL-6 and ligands of CXCR2. Jci Insight. 7. PMID 35708907 DOI: 10.1172/jci.insight.158207  0.801
2022 Espinoza I, Yang L, Steen TV, Vellon L, Cuyàs E, Verdura S, Lau L, Menendez JA, Lupu R. Binding of the angiogenic/senescence inducer CCN1/CYR61 to integrin αβ drives endocrine resistance in breast cancer cells. Aging. 14: 1200-1213. PMID 35148282 DOI: 10.18632/aging.203882  0.3
2020 Jun JI, Lau LF. CCN1 is an opsonin for bacterial clearance and a direct activator of Toll-like receptor signaling. Nature Communications. 11: 1242. PMID 32144270 DOI: 10.1038/S41467-020-15075-5  0.498
2020 Wu J, Tian WJ, Liu Y, Wang HJ, Zheng J, Wang X, Pan H, Li J, Luo J, Yang X, Lau LF, Ghashghaei HT, Shen Q. Ependyma-expressed CCN1 restricts the size of the neural stem cell pool in the adult ventricular-subventricular zone. The Embo Journal. e101679. PMID 32009252 DOI: 10.15252/Embj.2019101679  0.305
2018 Kim KH, Won JH, Cheng N, Lau LF. The matricellular protein CCN1 in tissue injury repair. Journal of Cell Communication and Signaling. PMID 29357009 DOI: 10.1007/S12079-018-0450-X  0.785
2018 Jun JI, Lau LF. Resolution of organ fibrosis. The Journal of Clinical Investigation. 128: 97-107. PMID 29293097 DOI: 10.1172/Jci93563  0.509
2017 Vaidya R, Zambrano R, Hummler JK, Luo S, Duncan MR, Young K, Lau LF, Wu S. Recombinant CCN1 prevents hyperoxia-induced lung injury in neonatal rats. Pediatric Research. PMID 28700567 DOI: 10.1038/Pr.2017.160  0.304
2017 Lee S, Elaskandrany M, Lau LF, Lazzaro D, Grant MB, Chaqour B. Interplay between CCN1 and Wnt5a in endothelial cells and pericytes determines the angiogenic outcome in a model of ischemic retinopathy. Scientific Reports. 7: 1405. PMID 28469167 DOI: 10.1038/S41598-017-01585-8  0.468
2017 Monzon RI, Kim KH, Lau LF. Construction and Analysis of an Allelic Series of Ccn1 Knockin Mice. Methods in Molecular Biology (Clifton, N.J.). 1489: 361-376. PMID 27734389 DOI: 10.1007/978-1-4939-6430-7_30  0.775
2016 Jun JI, Lau LF. CCN2 induces cellular senescence in fibroblasts. Journal of Cell Communication and Signaling. PMID 27752926 DOI: 10.1007/S12079-016-0359-1  0.581
2016 Lau LF. Cell surface receptors for CCN proteins. Journal of Cell Communication and Signaling. PMID 27098435 DOI: 10.1007/S12079-016-0324-Z  0.362
2015 Kim KH, Lau LF. CCN1 in hepatobiliary injury repair. Oncotarget. 6: 34053-4. PMID 26474457 DOI: 10.18632/Oncotarget.6079  0.549
2015 Jun JI, Kim KH, Lau LF. The matricellular protein CCN1 mediates neutrophil efferocytosis in cutaneous wound healing. Nature Communications. 6: 7386. PMID 26077348 DOI: 10.1038/Ncomms8386  0.591
2015 Chen CC, Kim KH, Lau LF. The matricellular protein CCN1 suppresses hepatocarcinogenesis by inhibiting compensatory proliferation. Oncogene. PMID 26028023 DOI: 10.1038/Onc.2015.190  0.613
2015 Chintala H, Krupska I, Yan L, Lau L, Grant M, Chaqour B. The matricellular protein CCN1 controls retinal angiogenesis by targeting VEGF, Src homology 2 domain phosphatase-1 and Notch signaling Development (Cambridge). 142: 2364-2374. PMID 26002917 DOI: 10.1242/Dev.121913  0.417
2015 Kim KH, Chen CC, Alpini G, Lau LF. CCN1 induces hepatic ductular reaction through integrin αvβ₅-mediated activation of NF-κB. The Journal of Clinical Investigation. 125: 1886-900. PMID 25822023 DOI: 10.1172/Jci79327  0.649
2015 Choi JS, Kim KH, Lau LF. The matricellular protein CCN1 promotes mucosal healing in murine colitis through IL-6. Mucosal Immunology. PMID 25807183 DOI: 10.1038/Mi.2015.19  0.354
2014 Zhao Y, Li Q, Katzenellenbogen BS, Lau LF, Taylor RN, Bagchi IC, Bagchi MK. Estrogen-induced CCN1 is critical for establishment of endometriosis-like lesions in mice. Molecular Endocrinology (Baltimore, Md.). 28: 1934-47. PMID 25321413 DOI: 10.1210/Me.2014-1080  0.346
2014 Zhao X, Ding EY, Yu OM, Xiang SY, Tan-Sah VP, Yung BS, Hedgpeth J, Neubig RR, Lau LF, Brown JH, Miyamoto S. Induction of the matricellular protein CCN1 through RhoA and MRTF-A contributes to ischemic cardioprotection. Journal of Molecular and Cellular Cardiology. 75: 152-61. PMID 25106095 DOI: 10.1016/J.Yjmcc.2014.07.017  0.396
2013 Choi J, Lin A, Shrier E, Lau LF, Grant MB, Chaqour B. Degradome products of the matricellular protein CCN1 as modulators of pathological angiogenesis in the retina. The Journal of Biological Chemistry. 288: 23075-89. PMID 23798676 DOI: 10.1074/Jbc.M113.475418  0.439
2013 Kim KH, Chen CC, Monzon RI, Lau LF. Matricellular protein CCN1 promotes regression of liver fibrosis through induction of cellular senescence in hepatic myofibroblasts. Molecular and Cellular Biology. 33: 2078-90. PMID 23508104 DOI: 10.1128/Mcb.00049-13  0.782
2013 Zemans RL, McClendon J, Aschner Y, Briones N, Young SK, Lau LF, Kahn M, Downey GP. Role of β-catenin-regulated CCN matricellular proteins in epithelial repair after inflammatory lung injury. American Journal of Physiology. Lung Cellular and Molecular Physiology. 304: L415-27. PMID 23316072 DOI: 10.1152/Ajplung.00180.2012  0.337
2012 Lau LF. CCN1 and CCN2: blood brothers in angiogenic action. Journal of Cell Communication and Signaling. 6: 121-3. PMID 22833463 DOI: 10.1007/S12079-012-0169-Z  0.42
2012 Juric V, Chen CC, Lau LF. TNFα-induced apoptosis enabled by CCN1/CYR61: pathways of reactive oxygen species generation and cytochrome c release. Plos One. 7: e31303. PMID 22363611 DOI: 10.1371/Journal.Pone.0031303  0.809
2011 Jun JI, Lau LF. Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets. Nature Reviews. Drug Discovery. 10: 945-63. PMID 22129992 DOI: 10.1038/Nrd3599  0.501
2011 Lau LF. CCN1/CYR61: the very model of a modern matricellular protein. Cellular and Molecular Life Sciences : Cmls. 68: 3149-63. PMID 21805345 DOI: 10.1007/S00018-011-0778-3  0.48
2011 Park HJ, Gusarova G, Wang Z, Carr JR, Li J, Kim KH, Qiu J, Park YD, Williamson PR, Hay N, Tyner AL, Lau LF, Costa RH, Raychaudhuri P. Deregulation of FoxM1b leads to tumour metastasis. Embo Molecular Medicine. 3: 21-34. PMID 21204266 DOI: 10.1002/Emmm.201000107  0.48
2011 Chen CC, Juric V, Lau LF. The extracellular matrix protein CCN1 dictates TNFα and FasL cytotoxicity in vivo. Advances in Experimental Medicine and Biology. 691: 595-603. PMID 21153366 DOI: 10.1007/978-1-4419-6612-4_63  0.822
2010 Jun JI, Lau LF. Cellular senescence controls fibrosis in wound healing. Aging. 2: 627-31. PMID 20930261  0.442
2010 Jun JI, Lau LF. The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing. Nature Cell Biology. 12: 676-85. PMID 20526329 DOI: 10.1038/Ncb2070  0.589
2010 Petrovic V, Costa RH, Lau LF, Raychaudhuri P, Tyner AL. Negative regulation of the oncogenic transcription factor FoxM1 by thiazolidinediones and mithramycin. Cancer Biology & Therapy. 9: 1008-16. PMID 20372080 DOI: 10.4161/Cbt.9.12.11710  0.432
2010 Bai T, Chen CC, Lau LF. Matricellular protein CCN1 activates a proinflammatory genetic program in murine macrophages. Journal of Immunology (Baltimore, Md. : 1950). 184: 3223-32. PMID 20164416 DOI: 10.4049/Jimmunol.0902792  0.682
2010 Chen CC, Lau LF. Deadly liaisons: fatal attraction between CCN matricellular proteins and the tumor necrosis factor family of cytokines. Journal of Cell Communication and Signaling. 4: 63-9. PMID 19898959 DOI: 10.1007/S12079-009-0080-4  0.663
2010 Jun JI, Lau LF. Erratum: The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing (Nature Cell Biology (2010) 12 DOI: 10.1038/ncb2070) Nature Cell Biology. 12. DOI: 10.1038/Ncb1210-1249  0.421
2009 Chen YJ, Dominguez-Brauer C, Wang Z, Asara JM, Costa RH, Tyner AL, Lau LF, Raychaudhuri P. A conserved phosphorylation site within the forkhead domain of FoxM1B is required for its activation by cyclin-CDK1. The Journal of Biological Chemistry. 284: 30695-707. PMID 19737929 DOI: 10.1074/Jbc.M109.007997  0.371
2009 Park HJ, Carr JR, Wang Z, Nogueira V, Hay N, Tyner AL, Lau LF, Costa RH, Raychaudhuri P. FoxM1, a critical regulator of oxidative stress during oncogenesis. The Embo Journal. 28: 2908-18. PMID 19696738 DOI: 10.1038/Emboj.2009.239  0.377
2009 Katsube K, Ichikawa S, Katsuki Y, Kihara T, Terai M, Lau LF, Tamamura Y, Takeda S, Umezawa A, Sakamoto K, Yamaguchi A. CCN3 and bone marrow cells. Journal of Cell Communication and Signaling. 3: 135-45. PMID 19626464 DOI: 10.1007/S12079-009-0059-1  0.323
2009 Franzen CA, Chen CC, Todorović V, Juric V, Monzon RI, Lau LF. Matrix protein CCN1 is critical for prostate carcinoma cell proliferation and TRAIL-induced apoptosis. Molecular Cancer Research : McR. 7: 1045-55. PMID 19584265 DOI: 10.1158/1541-7786.Mcr-09-0017  0.787
2009 Hanna M, Liu H, Amir J, Sun Y, Morris SW, Siddiqui MA, Lau LF, Chaqour B. Mechanical regulation of the proangiogenic factor CCN1/CYR61 gene requires the combined activities of MRTF-A and CREB-binding protein histone acetyltransferase. The Journal of Biological Chemistry. 284: 23125-36. PMID 19542562 DOI: 10.1074/Jbc.M109.019059  0.422
2009 Juric V, Chen CC, Lau LF. Fas-mediated apoptosis is regulated by the extracellular matrix protein CCN1 (CYR61) in vitro and in vivo. Molecular and Cellular Biology. 29: 3266-79. PMID 19364818 DOI: 10.1128/Mcb.00064-09  0.822
2009 Chen CC, Lau LF. Functions and mechanisms of action of CCN matricellular proteins. The International Journal of Biochemistry & Cell Biology. 41: 771-83. PMID 18775791 DOI: 10.1016/J.Biocel.2008.07.025  0.676
2008 Park HJ, Costa RH, Lau LF, Tyner AL, Raychaudhuri P. Anaphase-promoting complex/cyclosome-CDH1-mediated proteolysis of the forkhead box M1 transcription factor is critical for regulated entry into S phase. Molecular and Cellular Biology. 28: 5162-71. PMID 18573889 DOI: 10.1128/Mcb.00387-08  0.341
2008 Pestov DG, Lapik YR, Lau LF. Assays for ribosomal RNA processing and ribosome assembly. Current Protocols in Cell Biology / Editorial Board, Juan S. Bonifacino ... [Et Al.]. Unit 22.11. PMID 18551418 DOI: 10.1002/0471143030.Cb2211S39  0.786
2008 Wang IC, Chen YJ, Hughes DE, Ackerson T, Major ML, Kalinichenko VV, Costa RH, Raychaudhuri P, Tyner AL, Lau LF. FoxM1 regulates transcription of JNK1 to promote the G1/S transition and tumor cell invasiveness. The Journal of Biological Chemistry. 283: 20770-8. PMID 18524773 DOI: 10.1074/Jbc.M709892200  0.425
2008 Petrovic V, Costa RH, Lau LF, Raychaudhuri P, Tyner AL. FoxM1 regulates growth factor-induced expression of kinase-interacting stathmin (KIS) to promote cell cycle progression. The Journal of Biological Chemistry. 283: 453-60. PMID 17984092 DOI: 10.1074/Jbc.M705792200  0.407
2008 Park HJ, Wang Z, Costa RH, Tyner A, Lau LF, Raychaudhuri P. An N-terminal inhibitory domain modulates activity of FoxM1 during cell cycle. Oncogene. 27: 1696-704. PMID 17891172 DOI: 10.1038/Sj.Onc.1210814  0.367
2007 Lapik YR, Misra JM, Lau LF, Pestov DG. Restricting conformational flexibility of the switch II region creates a dominant-inhibitory phenotype in Obg GTPase Nog1. Molecular and Cellular Biology. 27: 7735-44. PMID 17785438 DOI: 10.1128/Mcb.01161-07  0.788
2007 Chen CC, Young JL, Monzon RI, Chen N, Todorović V, Lau LF. Cytotoxicity of TNFalpha is regulated by integrin-mediated matrix signaling. The Embo Journal. 26: 1257-67. PMID 17318182 DOI: 10.1038/Sj.Emboj.7601596  0.801
2006 Mo FE, Lau LF. The matricellular protein CCN1 is essential for cardiac development. Circulation Research. 99: 961-9. PMID 17023674 DOI: 10.1161/01.Res.0000248426.35019.89  0.778
2005 Todorovic V, Chen CC, Hay N, Lau LF. The matrix protein CCN1 (CYR61) induces apoptosis in fibroblasts. The Journal of Cell Biology. 171: 559-68. PMID 16275757 DOI: 10.1083/Jcb.200504015  0.658
2005 Zhang W, Swanson R, Izaguirre G, Xiong Y, Lau LF, Olson ST. The heparin-binding site of antithrombin is crucial for antiangiogenic activity. Blood. 106: 1621-8. PMID 15905187 DOI: 10.1182/Blood-2005-02-0547  0.4
2005 Lin CG, Chen CC, Leu SJ, Grzeszkiewicz TM, Lau LF. Integrin-dependent functions of the angiogenic inducer NOV (CCN3): implication in wound healing. The Journal of Biological Chemistry. 280: 8229-37. PMID 15611078 DOI: 10.1074/Jbc.M404903200  0.805
2004 Leu SJ, Chen N, Chen CC, Todorovic V, Bai T, Juric V, Liu Y, Yan G, Lam SC, Lau LF. Targeted mutagenesis of the angiogenic protein CCN1 (CYR61). Selective inactivation of integrin alpha6beta1-heparan sulfate proteoglycan coreceptor-mediated cellular functions. The Journal of Biological Chemistry. 279: 44177-87. PMID 15322081 DOI: 10.1074/Jbc.M407850200  0.782
2004 Chen N, Leu SJ, Todorovic V, Lam SC, Lau LF. Identification of a novel integrin alphavbeta3 binding site in CCN1 (CYR61) critical for pro-angiogenic activities in vascular endothelial cells. The Journal of Biological Chemistry. 279: 44166-76. PMID 15308622 DOI: 10.1074/Jbc.M406813200  0.815
2004 Lapik YR, Fernandes CJ, Lau LF, Pestov DG. Physical and functional interaction between Pes1 and Bop1 in mammalian ribosome biogenesis. Molecular Cell. 15: 17-29. PMID 15225545 DOI: 10.1016/J.Molcel.2004.05.020  0.793
2004 Zhang W, Chuang YJ, Swanson R, Li J, Seo K, Leung L, Lau LF, Olson ST. Antiangiogenic antithrombin down-regulates the expression of the proangiogenic heparan sulfate proteoglycan, perlecan, in endothelial cells. Blood. 103: 1185-91. PMID 14563633 DOI: 10.1182/Blood-2003-08-2920  0.47
2003 Leu SJ, Liu Y, Chen N, Chen CC, Lam SC, Lau LF. Identification of a novel integrin alpha 6 beta 1 binding site in the angiogenic inducer CCN1 (CYR61). The Journal of Biological Chemistry. 278: 33801-8. PMID 12826661 DOI: 10.1074/Jbc.M305862200  0.8
2003 Schober JM, Lau LF, Ugarova TP, Lam SC. Identification of a novel integrin alphaMbeta2 binding site in CCN1 (CYR61), a matricellular protein expressed in healing wounds and atherosclerotic lesions. The Journal of Biological Chemistry. 278: 25808-15. PMID 12736251 DOI: 10.1074/Jbc.M301534200  0.407
2003 Latinkic BV, Mercurio S, Bennett B, Hirst EM, Xu Q, Lau LF, Mohun TJ, Smith JC. Xenopus Cyr61 regulates gastrulation movements and modulates Wnt signalling. Development (Cambridge, England). 130: 2429-41. PMID 12702657 DOI: 10.1242/Dev.00449  0.451
2003 Lin CG, Leu SJ, Chen N, Tebeau CM, Lin SX, Yeung CY, Lau LF. CCN3 (NOV) is a novel angiogenic regulator of the CCN protein family. The Journal of Biological Chemistry. 278: 24200-8. PMID 12695522 DOI: 10.1074/Jbc.M302028200  0.825
2003 Brigstock DR, Goldschmeding R, Katsube KI, Lam SC, Lau LF, Lyons K, Naus C, Perbal B, Riser B, Takigawa M, Yeger H. Proposal for a unified CCN nomenclature. Molecular Pathology : Mp. 56: 127-8. PMID 12665631 DOI: 10.1136/Mp.56.2.127  0.384
2003 Kim KH, Min YK, Baik JH, Lau LF, Chaqour B, Chung KC. Expression of angiogenic factor Cyr61 during neuronal cell death via the activation of c-Jun N-terminal kinase and serum response factor. The Journal of Biological Chemistry. 278: 13847-54. PMID 12576482 DOI: 10.1074/jbc.M210128200  0.345
2002 Grzeszkiewicz TM, Lindner V, Chen N, Lam SC, Lau LF. The Angiogenic Factor Cysteine-Rich 61 (CYR61, CCN1) Supports Vascular Smooth Muscle Cell Adhesion and Stimulates Chemotaxis through Integrin α6β1 and Cell Surface Heparan Sulfate Proteoglycans. Endocrinology. 143: 1441-1450. PMID 28201606 DOI: 10.1210/endo.143.4.8731  0.789
2002 Mo FE, Muntean AG, Chen CC, Stolz DB, Watkins SC, Lau LF. CYR61 (CCN1) is essential for placental development and vascular integrity. Molecular and Cellular Biology. 22: 8709-20. PMID 12446788 DOI: 10.1128/Mcb.22.24.8709-8720.2002  0.823
2002 Leu SJ, Lam SC, Lau LF. Pro-angiogenic activities of CYR61 (CCN1) mediated through integrins alphavbeta3 and alpha6beta1 in human umbilical vein endothelial cells. The Journal of Biological Chemistry. 277: 46248-55. PMID 12364323 DOI: 10.1074/Jbc.M209288200  0.836
2002 Strezoska Z, Pestov DG, Lau LF. Functional inactivation of the mouse nucleolar protein Bop1 inhibits multiple steps in pre-rRNA processing and blocks cell cycle progression. The Journal of Biological Chemistry. 277: 29617-25. PMID 12048210 DOI: 10.1074/Jbc.M204381200  0.804
2002 Schober JM, Chen N, Grzeszkiewicz TM, Jovanovic I, Emeson EE, Ugarova TP, Ye RD, Lau LF, Lam SC. Identification of integrin alpha(M)beta(2) as an adhesion receptor on peripheral blood monocytes for Cyr61 (CCN1) and connective tissue growth factor (CCN2): immediate-early gene products expressed in atherosclerotic lesions. Blood. 99: 4457-65. PMID 12036876 DOI: 10.1182/Blood.V99.12.4457  0.821
2002 Grzeszkiewicz TM, Lindner V, Chen N, Lam SC, Lau LF. The angiogenic factor cysteine-rich 61 (CYR61, CCN1) supports vascular smooth muscle cell adhesion and stimulates chemotaxis through integrin alpha(6)beta(1) and cell surface heparan sulfate proteoglycans. Endocrinology. 143: 1441-50. PMID 11897702 DOI: 10.1210/Endo.143.4.8731  0.823
2002 Stocco CO, Lau LF, Gibori G. A calcium/calmodulin-dependent activation of ERK1/2 mediates JunD phosphorylation and induction of nur77 and 20alpha-hsd genes by prostaglandin F2alpha in ovarian cells. The Journal of Biological Chemistry. 277: 3293-302. PMID 11719525 DOI: 10.1074/Jbc.M110936200  0.402
2001 Chen CC, Mo FE, Lau LF. The angiogenic factor Cyr61 activates a genetic program for wound healing in human skin fibroblasts. The Journal of Biological Chemistry. 276: 47329-37. PMID 11584015 DOI: 10.1074/Jbc.M107666200  0.838
2001 Pestov DG, Stockelman MG, Strezoska Z, Lau LF. ERB1, the yeast homolog of mammalian Bop1, is an essential gene required for maturation of the 25S and 5.8S ribosomal RNAs. Nucleic Acids Research. 29: 3621-30. PMID 11522832 DOI: 10.1093/Nar/29.17.3621  0.344
2001 Pestov DG, Strezoska Z, Lau LF. Evidence of p53-dependent cross-talk between ribosome biogenesis and the cell cycle: effects of nucleolar protein Bop1 on G(1)/S transition. Molecular and Cellular Biology. 21: 4246-55. PMID 11390653 DOI: 10.1128/Mcb.21.13.4246-4255.2001  0.422
2001 Latinkic BV, Mo FE, Greenspan JA, Copeland NG, Gilbert DJ, Jenkins NA, Ross SR, Lau LF. Promoter function of the angiogenic inducer Cyr61gene in transgenic mice: tissue specificity, inducibility during wound healing, and role of the serum response element. Endocrinology. 142: 2549-57. PMID 11356704 DOI: 10.1210/Endo.142.6.8208  0.807
2001 Grzeszkiewicz TM, Kirschling DJ, Chen N, Lau LF. CYR61 stimulates human skin fibroblast migration through Integrin alpha vbeta 5 and enhances mitogenesis through integrin alpha vbeta 3, independent of its carboxyl-terminal domain. The Journal of Biological Chemistry. 276: 21943-50. PMID 11287419 DOI: 10.1074/Jbc.M100978200  0.814
2001 Chen CC, Chen N, Lau LF. The angiogenic factors Cyr61 and connective tissue growth factor induce adhesive signaling in primary human skin fibroblasts. The Journal of Biological Chemistry. 276: 10443-52. PMID 11120741 DOI: 10.1074/Jbc.M008087200  0.845
2000 Stocco CO, Zhong L, Sugimoto Y, Ichikawa A, Lau LF, Gibori G. Prostaglandin F2alpha-induced expression of 20alpha-hydroxysteroid dehydrogenase involves the transcription factor NUR77. The Journal of Biological Chemistry. 275: 37202-11. PMID 10973968 DOI: 10.1074/Jbc.M006016200  0.38
2000 Chung KC, Kim SM, Rhang S, Lau LF, Gomes I, Ahn YS. Expression of immediate early gene pip92 during anisomycin-induced cell death is mediated by the JNK- and p38-dependent activation of Elk1. European Journal of Biochemistry / Febs. 267: 4676-84. PMID 10903500 DOI: 10.1046/J.1432-1327.2000.01517.X  0.406
2000 Strezoska Z, Pestov DG, Lau LF. Bop1 is a mouse WD40 repeat nucleolar protein involved in 28S and 5. 8S RRNA processing and 60S ribosome biogenesis. Molecular and Cellular Biology. 20: 5516-28. PMID 10891491 DOI: 10.1128/Mcb.20.15.5516-5528.2000  0.409
2000 Chen N, Chen CC, Lau LF. Adhesion of human skin fibroblasts to Cyr61 is mediated through integrin alpha 6beta 1 and cell surface heparan sulfate proteoglycans. The Journal of Biological Chemistry. 275: 24953-61. PMID 10821835 DOI: 10.1074/Jbc.M003040200  0.839
2000 Li Y, Lau LF. IPTG-inducible episomal expression system for exogenous genes in primate cells. Biotechniques. 28: 577-81. PMID 10723574 DOI: 10.2144/00283Cr04  0.425
1999 Jedsadayanmata A, Chen CC, Kireeva ML, Lau LF, Lam SC. Activation-dependent adhesion of human platelets to Cyr61 and Fisp12/mouse connective tissue growth factor is mediated through integrin alpha(IIb)beta(3). The Journal of Biological Chemistry. 274: 24321-7. PMID 10446209 DOI: 10.1074/Jbc.274.34.24321  0.65
1999 Babic AM, Chen CC, Lau LF. Fisp12/mouse connective tissue growth factor mediates endothelial cell adhesion and migration through integrin alphavbeta3, promotes endothelial cell survival, and induces angiogenesis in vivo. Molecular and Cellular Biology. 19: 2958-66. PMID 10082563 DOI: 10.1128/Mcb.19.4.2958  0.679
1999 Pestov DG, Polonskaia M, Lau LF. Flow cytometric analysis of the cell cycle in transfected cells without cell fixation. Biotechniques. 26: 102-6. PMID 9894598 DOI: 10.2144/99261St04  0.346
1998 Pestov DG, Grzeszkiewicz TM, Lau LF. Isolation of growth suppressors from a cDNA expression library. Oncogene. 17: 3187-97. PMID 9872334 DOI: 10.1038/Sj.Onc.1202260  0.784
1998 Babic AM, Kireeva ML, Kolesnikova TV, Lau LF. CYR61, a product of a growth factor-inducible immediate early gene, promotes angiogenesis and tumor growth. Proceedings of the National Academy of Sciences of the United States of America. 95: 6355-60. PMID 9600969 DOI: 10.1073/Pnas.95.11.6355  0.495
1998 Chung KC, Gomes I, Wang D, Lau LF, Rosner MR. Raf and fibroblast growth factor phosphorylate Elk1 and activate the serum response element of the immediate early gene pip92 by mitogen-activated protein kinase-independent as well as -dependent signaling pathways. Molecular and Cellular Biology. 18: 2272-81. PMID 9528798 DOI: 10.1128/Mcb.18.4.2272  0.365
1998 Kolesnikova TV, Lau LF. Human CYR61-mediated enhancement of bFGF-induced DNA synthesis in human umbilical vein endothelial cells. Oncogene. 16: 747-54. PMID 9488038 DOI: 10.1038/Sj.Onc.1201572  0.477
1998 Kireeva ML, Lam SC, Lau LF. Adhesion of human umbilical vein endothelial cells to the immediate-early gene product Cyr61 is mediated through integrin alphavbeta3. The Journal of Biological Chemistry. 273: 3090-6. PMID 9446626 DOI: 10.1074/Jbc.273.5.3090  0.457
1997 Wong M, Kireeva ML, Kolesnikova TV, Lau LF. Cyr61, product of a growth factor-inducible immediate-early gene, regulates chondrogenesis in mouse limb bud mesenchymal cells. Developmental Biology. 192: 492-508. PMID 9441684 DOI: 10.1006/Dbio.1997.8766  0.482
1997 Li Y, Lau LF. Adrenocorticotropic hormone regulates the activities of the orphan nuclear receptor Nur77 through modulation of phosphorylation. Endocrinology. 138: 4138-46. PMID 9322922 DOI: 10.1210/Endo.138.10.5464  0.373
1997 Shiyanov P, Hayes S, Chen N, Pestov DG, Lau LF, Raychaudhuri P. p27Kip1 induces an accumulation of the repressor complexes of E2F and inhibits expression of the E2F-regulated genes. Molecular Biology of the Cell. 8: 1815-27. PMID 9307976 DOI: 10.1091/Mbc.8.9.1815  0.786
1997 Kireeva ML, Latinkić BV, Kolesnikova TV, Chen CC, Yang GP, Abler AS, Lau LF. Cyr61 and Fisp12 are both ECM-associated signaling molecules: activities, metabolism, and localization during development. Experimental Cell Research. 233: 63-77. PMID 9184077 DOI: 10.1006/Excr.1997.3548  0.672
1996 Kireeva ML, MO FE, Yang GP, Lau LF. Cyr61, a product of a growth factor-inducible immediate-early gene, promotes cell proliferation, migration, and adhesion. Molecular and Cellular Biology. 16: 1326-34. PMID 8657105 DOI: 10.1128/Mcb.16.4.1326  0.812
1995 Yazdanbakhsh K, Choi JW, Li Y, Lau LF, Choi Y. Cyclosporin A blocks apoptosis by inhibiting the DNA binding activity of the transcription factor Nur77. Proceedings of the National Academy of Sciences of the United States of America. 92: 437-41. PMID 7831306 DOI: 10.1073/Pnas.92.2.437  0.307
1994 Davis IJ, Lau LF. Endocrine and neurogenic regulation of the orphan nuclear receptors Nur77 and Nurr-1 in the adrenal glands. Molecular and Cellular Biology. 14: 3469-83. PMID 8164692 DOI: 10.1128/Mcb.14.5.3469  0.42
1994 Yoon JK, Lau LF. Involvement of JunD in transcriptional activation of the orphan receptor gene nur77 by nerve growth factor and membrane depolarization in PC12 cells. Molecular and Cellular Biology. 14: 7731-43. PMID 7969116 DOI: 10.1128/Mcb.14.12.7731  0.37
1994 Wu J, Lau LF, Sturgill TW. Rapid deactivation of MAP kinase in PC12 cells occurs independently of induction of phosphatase MKP-1. Febs Letters. 353: 9-12. PMID 7926031 DOI: 10.1016/0014-5793(94)01000-5  0.314
1994 Pestov DG, Lau LF. Genetic selection of growth-inhibitory sequences in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America. 91: 12549-53. PMID 7809075 DOI: 10.1073/Pnas.91.26.12549  0.363
1993 Williams GT, Lau LF. Activation of the inducible orphan receptor gene nur77 by serum growth factors: dissociation of immediate-early and delayed-early responses. Molecular and Cellular Biology. 13: 6124-36. PMID 8413214 DOI: 10.1128/Mcb.13.10.6124  0.392
1993 Charles CH, Sun H, Lau LF, Tonks NK. The growth factor-inducible immediate-early gene 3CH134 encodes a protein-tyrosine-phosphatase. Proceedings of the National Academy of Sciences of the United States of America. 90: 5292-6. PMID 8389479 DOI: 10.1073/Pnas.90.11.5292  0.314
1993 Davis IJ, Hazel TG, Chen RH, Blenis J, Lau LF. Functional domains and phosphorylation of the orphan receptor Nur77. Molecular Endocrinology (Baltimore, Md.). 7: 953-64. PMID 8232315 DOI: 10.1210/Mend.7.8.8232315  0.721
1993 Sun H, Charles CH, Lau LF, Tonks NK. MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo. Cell. 75: 487-93. PMID 8221888 DOI: 10.1016/0092-8674(93)90383-2  0.3
1991 Latinkic BV, O'Brien TP, Lau LF. Promoter function and structure of the growth factor-inducible immediate early gene cyr61. Nucleic Acids Research. 19: 3261-7. PMID 2062642 DOI: 10.1093/Nar/19.12.3261  0.412
1991 Christy BA, Sanders LK, Lau LF, Copeland NG, Jenkins NA, Nathans D. An Id-related helix-loop-helix protein encoded by a growth factor-inducible gene. Proceedings of the National Academy of Sciences of the United States of America. 88: 1815-9. PMID 2000388 DOI: 10.1073/Pnas.88.5.1815  0.662
1991 Davis IJ, Hazel TG, Lau LF. Transcriptional activation by Nur77, a growth factor-inducible member of the steroid hormone receptor superfamily. Molecular Endocrinology (Baltimore, Md.). 5: 854-9. PMID 1922099 DOI: 10.1210/Mend-5-6-854  0.739
1991 Devary Y, Gottlieb RA, Lau LF, Karin M. Rapid and preferential activation of the c-jun gene during the mammalian UV response. Molecular and Cellular Biology. 11: 2804-11. PMID 1901948 DOI: 10.1128/Mcb.11.5.2804  0.334
1991 Hazel TG, Misra R, Davis IJ, Greenberg ME, Lau LF. Nur77 is differentially modified in PC12 cells upon membrane depolarization and growth factor treatment. Molecular and Cellular Biology. 11: 3239-46. PMID 1645447 DOI: 10.1128/Mcb.11.6.3239  0.738
1990 O'Brien TP, Yang GP, Sanders L, Lau LF. Expression of cyr61, a growth factor-inducible immediate-early gene. Molecular and Cellular Biology. 10: 3569-77. PMID 2355916 DOI: 10.1128/Mcb.10.7.3569  0.397
1990 Charles CH, Simske JS, O'Brien TP, Lau LF. Pip92: a short-lived, growth factor-inducible protein in BALB/c 3T3 and PC12 cells. Molecular and Cellular Biology. 10: 6769-74. PMID 2247083 DOI: 10.1128/Mcb.10.12.6769  0.429
1990 DuBois RN, McLane MW, Ryder K, Lau LF, Nathans D. A growth factor-inducible nuclear protein with a novel cysteine/histidine repetitive sequence. The Journal of Biological Chemistry. 265: 19185-91. PMID 1699942  0.645
1989 Hartzell S, Ryder K, Lanahan A, Lau LF, Nathan D. A growth factor-responsive gene of murine BALB/c 3T3 cells encodes a protein homologous to human tissue factor. Molecular and Cellular Biology. 9: 2567-73. PMID 2761539 DOI: 10.1128/MCB.9.6.2567  0.34
1989 Bartel DP, Sheng M, Lau LF, Greenberg ME. Growth factors and membrane depolarization activate distinct programs of early response gene expression: dissociation of fos and jun induction. Genes & Development. 3: 304-13. PMID 2498163 DOI: 10.1101/Gad.3.3.304  0.369
1988 Ryder K, Lau LF, Nathans D. A gene activated by growth factors is related to the oncogene v-jun. Proceedings of the National Academy of Sciences of the United States of America. 85: 1487-91. PMID 3422745 DOI: 10.1073/Pnas.85.5.1487  0.635
1988 Hazel TG, Nathans D, Lau LF. A gene inducible by serum growth factors encodes a member of the steroid and thyroid hormone receptor superfamily. Proceedings of the National Academy of Sciences of the United States of America. 85: 8444-8. PMID 3186734 DOI: 10.1073/Pnas.85.22.8444  0.799
1988 Nathans D, Lau LF, Christy B, Hartzell S, Nakabeppu Y, Ryder K. Genomic response to growth factors. Cold Spring Harbor Symposia On Quantitative Biology. 53: 893-900. PMID 3151190 DOI: 10.1101/Sqb.1988.053.01.102  0.562
1988 Christy BA, Lau LF, Nathans D. A gene activated in mouse 3T3 cells by serum growth factors encodes a protein with "zinc finger" sequences. Proceedings of the National Academy of Sciences of the United States of America. 85: 7857-61. PMID 3141919 DOI: 10.1073/Pnas.85.21.7857  0.641
1987 Lau LF, Nathans D. Expression of a set of growth-related immediate early genes in BALB/c 3T3 cells: coordinate regulation with c-fos or c-myc. Proceedings of the National Academy of Sciences of the United States of America. 84: 1182-6. PMID 3469660 DOI: 10.1073/Pnas.84.5.1182  0.622
1985 Lau LF, Nathans D. Identification of a set of genes expressed during the G0/G1 transition of cultured mouse cells. The Embo Journal. 4: 3145-51. PMID 3841511 DOI: 10.1002/J.1460-2075.1985.Tb04057.X  0.602
1985 Grayhack EJ, Yang XJ, Lau LF, Roberts JW. Phage lambda gene Q antiterminator recognizes RNA polymerase near the promoter and accelerates it through a pause site. Cell. 42: 259-69. PMID 2990726 DOI: 10.1016/S0092-8674(85)80121-5  0.464
1984 Lau LF, Roberts JW, Wu R, Georges F, Narang SA. A potential stem-loop structure and the sequence CAAUCAA in the transcript are insufficient to signal rho-dependent transcription termination at lambda tR1. Nucleic Acids Research. 12: 1287-99. PMID 6320123 DOI: 10.1093/Nar/12.2.1287  0.596
1982 Lau LF, Roberts JW, Wu R. Transcription terminates at lambda tR1 in three clusters. Proceedings of the National Academy of Sciences of the United States of America. 79: 6171-5. PMID 6216477 DOI: 10.1073/Pnas.79.20.6171  0.626
1979 Rothstein RJ, Lau LF, Bahl CP, Narang SA, Wu R. Synthetic adaptors for cloning DNA. Methods in Enzymology. 68: 98-109. PMID 232227 DOI: 10.1016/0076-6879(79)68009-6  0.396
Low-probability matches (unlikely to be authored by this person)
1996 Latinkić BV, Zeremski M, Lau LF. Elk-1 can recruit SRF to form a ternary complex upon the serum response element. Nucleic Acids Research. 24: 1345-51. PMID 8614640 DOI: 10.1093/Nar/24.7.1345  0.3
1999 Lau LF, Lam SC. The CCN family of angiogenic regulators: the integrin connection. Experimental Cell Research. 248: 44-57. PMID 10094812 DOI: 10.1006/Excr.1999.4456  0.299
2003 Henning D, So RB, Jin R, Lau LF, Valdez BC. Silencing of RNA helicase II/Gualpha inhibits mammalian ribosomal RNA production. The Journal of Biological Chemistry. 278: 52307-14. PMID 14559904 DOI: 10.1074/Jbc.M310846200  0.291
2019 Feng T, Meng J, Kou S, Jiang Z, Huang X, Lu Z, Zhao H, Lau LF, Zhou B, Zhang H. CCN1-Induced Cellular Senescence Promotes Heart Regeneration. Circulation. 139: 2495-2498. PMID 31107624 DOI: 10.1161/Circulationaha.119.039530  0.29
2001 Grotendorst GR, Lau LF, Perbal B. CCN proteins are distinct from, and should not be considered members of, the insulin-like growth factor-binding protein superfamily. The Journal of Clinical Endocrinology and Metabolism. 86: 944-5. PMID 11158072 DOI: 10.1210/Jcem.86.2.7241-1  0.287
2014 Perbal B, Trackman P, Castellot J, Brigstock D, Takigawa M, Lau L, Leask A. Report on the 7th international workshop on the CCN family of genes: October 16-19, 2013-Nice, France Journal of Cell Communication and Signaling. 8: 71-76. DOI: 10.1007/S12079-014-0227-9  0.281
1998 Hwang LH, Lau LF, Smith DL, Mistrot CA, Hardwick KG, Hwang ES, Amon A, Murray AW. Budding yeast Cdc20: a target of the spindle checkpoint. Science (New York, N.Y.). 279: 1041-4. PMID 9461437 DOI: 10.1126/Science.279.5353.1041  0.241
2005 Jin Y, Kim HP, Ifedigbo E, Lau LF, Choi AM. Cyr61 protects against hyperoxia-induced cell death via Akt pathway in pulmonary epithelial cells. American Journal of Respiratory Cell and Molecular Biology. 33: 297-302. PMID 15961723 DOI: 10.1165/rcmb.2005-0144OC  0.239
2018 Yeger H, Brigstock D, Fisher G, Lau L, Leask A, Perbal B. Report on the 9th international workshop on the CCN family of genes, November 2-7, 2017, Saint-Malo, France. Journal of Cell Communication and Signaling. PMID 29926396 DOI: 10.1007/S12079-018-0472-4  0.236
2016 Perbal B, Lau L, Lyons K, Kubota S, Yeger H, Fisher G. Report on the 8th international workshop on the CCN family of genes - Nice November 3-8, 2015. Journal of Cell Communication and Signaling. 10: 77-86. PMID 26920000 DOI: 10.1007/S12079-016-0317-Y  0.231
2020 Todoric J, Di Caro G, Reibe S, Henstridge DC, Green CR, Vrbanac A, Ceteci F, Conche C, McNulty R, Shalapour S, Taniguchi K, Meikle PJ, Watrous JD, Moranchel R, Najhawan M, ... ... Lau LF, et al. Fructose stimulated de novo lipogenesis is promoted by inflammation. Nature Metabolism. PMID 32839596 DOI: 10.1038/s42255-020-0261-2  0.216
2006 Raychaudhuri P, Lau LF, Grayson DR, Kaplan J. Robert H. Costa: In Memoriam (1957-2006) Cancer Research. 66: 11515-11515. DOI: 10.1158/0008-5472.Can-06-3887  0.209
2006 Raychaudhuri P, Lau LF, Grayson D, Kaplan J. Robert H. Costa: 1957-2006. Hepatology (Baltimore, Md.). 44: 1364. PMID 17058235 DOI: 10.1002/Hep.21410  0.191
1988 Schweinfest CW, Fujiwara S, Lau LF, Papas TS. c-myc can induce expression of G0/G1 transition genes. Molecular and Cellular Biology. 8: 3080-7. PMID 3211137 DOI: 10.1128/MCB.8.8.3080  0.186
1985 Lau LF, Roberts JW. Rho-dependent transcription termination at lambda R1 requires upstream sequences. The Journal of Biological Chemistry. 260: 574-84. PMID 2981220  0.184
2022 Chaqour B, Grant MB, Lau LF, Wang B, Urbanski MM, Melendez-Vasquez CV. Atomic Force Microscopy-Based Measurements of Retinal Microvessel Stiffness in Mice with Endothelial-Specific Deletion of CCN1. Methods in Molecular Biology (Clifton, N.J.). 2582: 323-334. PMID 36370360 DOI: 10.1007/978-1-0716-2744-0_22  0.178
1983 Lau LF, Roberts JW, Wu R. RNA polymerase pausing and transcript release at the lambda tR1 terminator in vitro. The Journal of Biological Chemistry. 258: 9391-7. PMID 6308007  0.164
2015 Kaur S, Wershil BK, Kagalwalla A, Amsden K, Laffey KG, Wechsler JB, Lau LF, Ackerman SJ. Su1107 Loss of Expression of the Matricellular Protein CCN1 in Eosinophilic Esophagitis: Implications for Disease Pathogenesis Gastroenterology. 148: S-409-S-410. DOI: 10.1016/S0016-5085(15)31378-0  0.148
1990 Lau LF. Growth factors and growth control. Current Opinion in Cell Biology. 2: 280-4. PMID 2163660 DOI: 10.1016/0955-0674(90)90020-F  0.131
2023 Attramadal H, Banerjee SK, Chaqour B, Fisher G, Lau L, Perbal B, Smith U, Yeger H. Report on the 11th international workshop on the CCN family of genes, Nice, October 20-24, 2022. Journal of Cell Communication and Signaling. 1-5. PMID 36790605 DOI: 10.1007/s12079-023-00731-4  0.099
2013 Huang Y, Li T, Eatherton A, Mitchell WL, Rong N, Ye L, Yang XJ, Jin S, Ding Y, Zhang J, Li Y, Wu Y, Jin Y, Sang Y, Cheng Z, ... ... Lau LF, et al. Orally bioavailable and brain-penetrant pyridazine and pyridine-derived γ-secretase modulators reduced amyloidogenic Aβ peptides in vivo. Neuropharmacology. 70: 278-86. PMID 23485401 DOI: 10.1016/j.neuropharm.2013.02.003  0.094
2001 Ayer-Lelievre C, Brigstock D, Lau L, Pennica D, Perbal B, Yeger H. Report and abstracts on the first international workshop on the CCN family of genes. Molecular Pathology : Mp. 54: 105-20. PMID 11322166 DOI: 10.1136/mp.54.2.105  0.093
2005 Brigstock D, Lau L, Perbal B. Report and abstracts of the 3rd International Workshop on the CCN Family of Genes. St Malo, France, 20-23 October 2004. Journal of Clinical Pathology. 58: 463-78. PMID 15858115 DOI: 10.1136/jcp.2005.025759  0.091
2003 Perbal B, Brigstock DR, Lau LF. Report on the second international workshop on the CCN family of genes. Molecular Pathology : Mp. 56: 80-5. PMID 12665625 DOI: 10.1136/mp.56.2.80  0.084
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