Curt M. Horvath - Publications

Icahn School of Medicine at Mount Sinai, New York, NY, United States 
Molecular Biology, Cell Biology, Biochemistry

62 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Parisien JP, Lenoir JJ, Mandhana R, Rodriguez KR, Qian K, Bruns AM, Horvath CM. RNA sensor LGP2 inhibits TRAF ubiquitin ligase to negatively regulate innate immune signaling. Embo Reports. PMID 29661858 DOI: 10.15252/embr.201745176  0.8
2015 Gale M, Horvath CM. Editorial overview: Antiviral strategies. Current Opinion in Virology. 12: v-vii. PMID 26004174 DOI: 10.1016/j.coviro.2015.05.001  1
2015 Bruns AM, Horvath CM. LGP2 synergy with MDA5 in RLR-mediated RNA recognition and antiviral signaling. Cytokine. 74: 198-206. PMID 25794939 DOI: 10.1016/j.cyto.2015.02.010  1
2015 Horvath CM. A serpin takes a bite out of the flu. Cell Host & Microbe. 17: 283-4. PMID 25766286 DOI: 10.1016/j.chom.2015.02.018  1
2014 Tell RW, Horvath CM. Bioinformatic analysis reveals a pattern of STAT3-associated gene expression specific to basal-like breast cancers in human tumors. Proceedings of the National Academy of Sciences of the United States of America. 111: 12787-92. PMID 25139989 DOI: 10.1073/pnas.1404881111  1
2014 Bruns AM, Leser GP, Lamb RA, Horvath CM. The innate immune sensor LGP2 activates antiviral signaling by regulating MDA5-RNA interaction and filament assembly. Molecular Cell. 55: 771-81. PMID 25127512 DOI: 10.1016/j.molcel.2014.07.003  1
2014 Bruns AM, Horvath CM. Antiviral RNA recognition and assembly by RLR family innate immune sensors. Cytokine & Growth Factor Reviews. 25: 507-12. PMID 25081315 DOI: 10.1016/j.cytogfr.2014.07.006  1
2014 Rodriguez KR, Bruns AM, Horvath CM. MDA5 and LGP2: accomplices and antagonists of antiviral signal transduction. Journal of Virology. 88: 8194-200. PMID 24850739 DOI: 10.1128/JVI.00640-14  1
2014 Rodriguez KR, Horvath CM. Paramyxovirus V protein interaction with the antiviral sensor LGP2 disrupts MDA5 signaling enhancement but is not relevant to LGP2-mediated RLR signaling inhibition. Journal of Virology. 88: 8180-8. PMID 24829334 DOI: 10.1128/JVI.00737-14  1
2014 Freaney JE, Zhang Q, Yigit E, Kim R, Widom J, Wang JP, Horvath CM. High-density nucleosome occupancy map of human chromosome 9p21-22 reveals chromatin organization of the type I interferon gene cluster. Journal of Interferon & Cytokine Research : the Official Journal of the International Society For Interferon and Cytokine Research. 34: 676-85. PMID 24673249 DOI: 10.1089/jir.2013.0118  1
2013 Buggele WA, Krause KE, Horvath CM. Small RNA profiling of influenza A virus-infected cells identifies miR-449b as a regulator of histone deacetylase 1 and interferon beta. Plos One. 8: e76560. PMID 24086750 DOI: 10.1371/journal.pone.0076560  1
2013 Buggele WA, Horvath CM. MicroRNA profiling of Sendai virus-infected A549 cells identifies miR-203 as an interferon-inducible regulator of IFIT1/ISG56. Journal of Virology. 87: 9260-70. PMID 23785202 DOI: 10.1128/JVI.01064-13  1
2013 Light WH, Freaney J, Sood V, Thompson A, D'Urso A, Horvath CM, Brickner JH. A conserved role for human Nup98 in altering chromatin structure and promoting epigenetic transcriptional memory. Plos Biology. 11: e1001524. PMID 23555195 DOI: 10.1371/journal.pbio.1001524  1
2013 Parisien JP, Horvath CM. Detection of activated STAT proteins. Methods in Molecular Biology (Clifton, N.J.). 967: 135-45. PMID 23296726 DOI: 10.1007/978-1-62703-242-1_9  1
2013 Rodriguez KR, Horvath CM. Amino acid requirements for MDA5 and LGP2 recognition by paramyxovirus V proteins: a single arginine distinguishes MDA5 from RIG-I. Journal of Virology. 87: 2974-8. PMID 23269789 DOI: 10.1128/JVI.02843-12  1
2013 Bruns AM, Pollpeter D, Hadizadeh N, Myong S, Marko JF, Horvath CM. ATP hydrolysis enhances RNA recognition and antiviral signal transduction by the innate immune sensor, laboratory of genetics and physiology 2 (LGP2). The Journal of Biological Chemistry. 288: 938-46. PMID 23184951 DOI: 10.1074/jbc.M112.424416  1
2012 Buggele WA, Johnson KE, Horvath CM. Influenza A virus infection of human respiratory cells induces primary microRNA expression. The Journal of Biological Chemistry. 287: 31027-40. PMID 22822053 DOI: 10.1074/jbc.M112.387670  1
2012 Bruns AM, Horvath CM. Activation of RIG-I-like receptor signal transduction. Critical Reviews in Biochemistry and Molecular Biology. 47: 194-206. PMID 22066529 DOI: 10.3109/10409238.2011.630974  1
2011 Pollpeter D, Komuro A, Barber GN, Horvath CM. Impaired cellular responses to cytosolic DNA or infection with Listeria monocytogenes and vaccinia virus in the absence of the murine LGP2 protein. Plos One. 6: e18842. PMID 21533147 DOI: 10.1371/journal.pone.0018842  1
2010 Ramachandran A, Horvath CM. Dissociation of paramyxovirus interferon evasion activities: universal and virus-specific requirements for conserved V protein amino acids in MDA5 interference. Journal of Virology. 84: 11152-63. PMID 20719949 DOI: 10.1128/JVI.01375-10  1
2009 Massich MD, Giljohann DA, Seferos DS, Ludlow LE, Horvath CM, Mirkin CA. Regulating immune response using polyvalent nucleic acid-gold nanoparticle conjugates. Molecular Pharmaceutics. 6: 1934-40. PMID 19810673 DOI: 10.1021/mp900172m  1
2009 Ramachandran A, Horvath CM. Paramyxovirus disruption of interferon signal transduction: STATus report. Journal of Interferon & Cytokine Research : the Official Journal of the International Society For Interferon and Cytokine Research. 29: 531-7. PMID 19694544 DOI: 10.1089/jir.2009.0070  1
2009 Parisien JP, Bamming D, Komuro A, Ramachandran A, Rodriguez JJ, Barber G, Wojahn RD, Horvath CM. A shared interface mediates paramyxovirus interference with antiviral RNA helicases MDA5 and LGP2. Journal of Virology. 83: 7252-60. PMID 19403670 DOI: 10.1128/JVI.00153-09  1
2009 Puri M, Lemon K, Duprex WP, Rima BK, Horvath CM. A point mutation, E95D, in the mumps virus V protein disengages STAT3 targeting from STAT1 targeting. Journal of Virology. 83: 6347-56. PMID 19386700 DOI: 10.1128/JVI.00596-09  1
2009 Bamming D, Horvath CM. Regulation of signal transduction by enzymatically inactive antiviral RNA helicase proteins MDA5, RIG-I, and LGP2. The Journal of Biological Chemistry. 284: 9700-12. PMID 19211564 DOI: 10.1074/jbc.M807365200  1
2008 Komuro A, Bamming D, Horvath CM. Negative regulation of cytoplasmic RNA-mediated antiviral signaling. Cytokine. 43: 350-8. PMID 18703349 DOI: 10.1016/j.cyto.2008.07.011  1
2008 Friedman CS, O'Donnell MA, Legarda-Addison D, Ng A, Cárdenas WB, Yount JS, Moran TM, Basler CF, Komuro A, Horvath CM, Xavier R, Ting AT. The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response. Embo Reports. 9: 930-6. PMID 18636086 DOI: 10.1038/embor.2008.136  1
2008 Ramachandran A, Parisien JP, Horvath CM. STAT2 is a primary target for measles virus V protein-mediated alpha/beta interferon signaling inhibition. Journal of Virology. 82: 8330-8. PMID 18579593 DOI: 10.1128/JVI.00831-08  1
2008 Ludlow LE, Lo MK, Rodriguez JJ, Rota PA, Horvath CM. Henipavirus V protein association with Polo-like kinase reveals functional overlap with STAT1 binding and interferon evasion. Journal of Virology. 82: 6259-71. PMID 18417573 DOI: 10.1128/JVI.00409-08  1
2008 Lu LL, Puri M, Horvath CM, Sen GC. Select paramyxoviral V proteins inhibit IRF3 activation by acting as alternative substrates for inhibitor of kappaB kinase epsilon (IKKe)/TBK1. The Journal of Biological Chemistry. 283: 14269-76. PMID 18362155 DOI: 10.1074/jbc.M710089200  1
2008 Kraus TA, Garza L, Horvath CM. Enabled interferon signaling evasion in an immune-competent transgenic mouse model of parainfluenza virus 5 infection. Virology. 371: 196-205. PMID 17964629 DOI: 10.1016/j.virol.2007.10.001  1
2006 Komuro A, Horvath CM. RNA- and virus-independent inhibition of antiviral signaling by RNA helicase LGP2. Journal of Virology. 80: 12332-42. PMID 17020950 DOI: 10.1128/JVI.01325-06  1
2006 Yount JS, Kraus TA, Horvath CM, Moran TM, López CB. A novel role for viral-defective interfering particles in enhancing dendritic cell maturation. Journal of Immunology (Baltimore, Md. : 1950). 177: 4503-13. PMID 16982887  1
2006 Cruz CD, Palosaari H, Parisien JP, Devaux P, Cattaneo R, Ouchi T, Horvath CM. Measles virus V protein inhibits p53 family member p73. Journal of Virology. 80: 5644-50. PMID 16699046 DOI: 10.1128/JVI.02400-05  1
2006 Nusinzon I, Horvath CM. Positive and negative regulation of the innate antiviral response and beta interferon gene expression by deacetylation. Molecular and Cellular Biology. 26: 3106-13. PMID 16581785 DOI: 10.1128/MCB.26.8.3106-3113.2006  1
2006 Gu W, Nusinzon I, Smith RD, Horvath CM, Silverman RB. Carbonyl- and sulfur-containing analogs of suberoylanilide hydroxamic acid: Potent inhibition of histone deacetylases. Bioorganic & Medicinal Chemistry. 14: 3320-9. PMID 16434199 DOI: 10.1016/j.bmc.2005.12.047  1
2005 Nusinzon I, Horvath CM. Unexpected roles for deacetylation in interferon- and cytokine-induced transcription. Journal of Interferon & Cytokine Research : the Official Journal of the International Society For Interferon and Cytokine Research. 25: 745-8. PMID 16375602 DOI: 10.1089/jir.2005.25.745  1
2005 Nusinzon I, Horvath CM. Histone deacetylases as transcriptional activators? Role reversal in inducible gene regulation. Science's Stke : Signal Transduction Knowledge Environment. 2005: re11. PMID 16091625 DOI: 10.1126/stke.2962005re11  1
2005 Ulane CM, Kentsis A, Cruz CD, Parisien JP, Schneider KL, Horvath CM. Composition and assembly of STAT-targeting ubiquitin ligase complexes: paramyxovirus V protein carboxyl terminus is an oligomerization domain. Journal of Virology. 79: 10180-9. PMID 16051811 DOI: 10.1128/JVI.79.16.10180-10189.2005  1
2004 Horvath CM. Weapons of STAT destruction. Interferon evasion by paramyxovirus V protein. European Journal of Biochemistry / Febs. 271: 4621-8. PMID 15606749 DOI: 10.1111/j.1432-1033.2004.04425.x  1
2004 Horvath CM. The Jak-STAT pathway stimulated by interleukin 6. Science's Stke : Signal Transduction Knowledge Environment. 2004: tr9. PMID 15561981 DOI: 10.1126/stke.2602004tr9  1
2004 Horvath CM. The Jak-STAT pathway stimulated by interferon gamma. Science's Stke : Signal Transduction Knowledge Environment. 2004: tr8. PMID 15561980 DOI: 10.1126/stke.2602004tr8  1
2004 Horvath CM. The Jak-STAT pathway stimulated by interferon alpha or interferon beta. Science's Stke : Signal Transduction Knowledge Environment. 2004: tr10. PMID 15561979 DOI: 10.1126/stke.2602004tr10  1
2004 Rodriguez JJ, Horvath CM. Host evasion by emerging paramyxoviruses: Hendra virus and Nipah virus v proteins inhibit interferon signaling. Viral Immunology. 17: 210-9. PMID 15279700 DOI: 10.1089/0882824041310568  1
2004 Rodriguez JJ, Cruz CD, Horvath CM. Identification of the nuclear export signal and STAT-binding domains of the Nipah virus V protein reveals mechanisms underlying interferon evasion. Journal of Virology. 78: 5358-67. PMID 15113915 DOI: 10.1128/JVI.78.10.5358-5367.2004  1
2004 Horvath CM. Silencing STATs: lessons from paramyxovirus interferon evasion. Cytokine & Growth Factor Reviews. 15: 117-27. PMID 15110796 DOI: 10.1016/j.cytogfr.2004.02.003  1
2003 Nusinzon I, Horvath CM. Interferon-stimulated transcription and innate antiviral immunity require deacetylase activity and histone deacetylase 1. Proceedings of the National Academy of Sciences of the United States of America. 100: 14742-7. PMID 14645718 DOI: 10.1073/pnas.2433987100  1
2003 Rodriguez JJ, Wang LF, Horvath CM. Hendra virus V protein inhibits interferon signaling by preventing STAT1 and STAT2 nuclear accumulation. Journal of Virology. 77: 11842-5. PMID 14557668 DOI: 10.1128/JVI.77.21.11842-11845.2003  1
2003 Palosaari H, Parisien JP, Rodriguez JJ, Ulane CM, Horvath CM. STAT protein interference and suppression of cytokine signal transduction by measles virus V protein. Journal of Virology. 77: 7635-44. PMID 12805463 DOI: 10.1128/JVI.77.13.7635-7644.2003  1
2003 Rogers RS, Horvath CM, Matunis MJ. SUMO modification of STAT1 and its role in PIAS-mediated inhibition of gene activation. The Journal of Biological Chemistry. 278: 30091-7. PMID 12764129 DOI: 10.1074/jbc.M301344200  1
2003 Ulane CM, Rodriguez JJ, Parisien JP, Horvath CM. STAT3 ubiquitylation and degradation by mumps virus suppress cytokine and oncogene signaling. Journal of Virology. 77: 6385-93. PMID 12743296 DOI: 10.1128/JVI.77.11.6385-6393.2003  1
2003 Kraus TA, Lau JF, Parisien JP, Horvath CM. A hybrid IRF9-STAT2 protein recapitulates interferon-stimulated gene expression and antiviral response. The Journal of Biological Chemistry. 278: 13033-8. PMID 12574168 DOI: 10.1074/jbc.M212972200  1
2003 Lau JF, Nusinzon I, Burakov D, Freedman LP, Horvath CM. Role of metazoan mediator proteins in interferon-responsive transcription. Molecular and Cellular Biology. 23: 620-8. PMID 12509459 DOI: 10.1128/MCB.23.2.620-628.2003  1
2002 Ulane CM, Horvath CM. Paramyxoviruses SV5 and HPIV2 assemble STAT protein ubiquitin ligase complexes from cellular components. Virology. 304: 160-6. PMID 12504558 DOI: 10.1006/viro.2002.1773  1
2002 Rodriguez JJ, Parisien JP, Horvath CM. Nipah virus V protein evades alpha and gamma interferons by preventing STAT1 and STAT2 activation and nuclear accumulation. Journal of Virology. 76: 11476-83. PMID 12388709 DOI: 10.1128/JVI.76.22.11476-11483.2002  1
2002 Parisien JP, Lau JF, Horvath CM. STAT2 acts as a host range determinant for species-specific paramyxovirus interferon antagonism and simian virus 5 replication. Journal of Virology. 76: 6435-41. PMID 12050355 DOI: 10.1128/JVI.76.13.6435-6441.2002  1
2002 Aaronson DS, Horvath CM. A road map for those who don't know JAK-STAT. Science (New York, N.Y.). 296: 1653-5. PMID 12040185 DOI: 10.1126/science.1071545  1
2002 Lau JF, Horvath CM. Mechanisms of Type I interferon cell signaling and STAT-mediated transcriptional responses. The Mount Sinai Journal of Medicine, New York. 69: 156-68. PMID 12035075  1
2002 Parisien JP, Lau JF, Rodriguez JJ, Ulane CM, Horvath CM. Selective STAT protein degradation induced by paramyxoviruses requires both STAT1 and STAT2 but is independent of alpha/beta interferon signal transduction. Journal of Virology. 76: 4190-8. PMID 11932384 DOI: 10.1128/JVI.76.9.4190-4198.2002  1
2002 Salvatore M, Basler CF, Parisien JP, Horvath CM, Bourmakina S, Zheng H, Muster T, Palese P, García-Sastre A. Effects of influenza A virus NS1 protein on protein expression: the NS1 protein enhances translation and is not required for shutoff of host protein synthesis. Journal of Virology. 76: 1206-12. PMID 11773396  1
2001 Parisien JP, Lau JF, Rodriguez JJ, Sullivan BM, Moscona A, Parks GD, Lamb RA, Horvath CM. The V protein of human parainfluenza virus 2 antagonizes type I interferon responses by destabilizing signal transducer and activator of transcription 2. Virology. 283: 230-9. PMID 11336548 DOI: 10.1006/viro.2001.0856  1
2000 Lau JF, Parisien JP, Horvath CM. Interferon regulatory factor subcellular localization is determined by a bipartite nuclear localization signal in the DNA-binding domain and interaction with cytoplasmic retention factors. Proceedings of the National Academy of Sciences of the United States of America. 97: 7278-83. PMID 10860992 DOI: 10.1073/pnas.97.13.7278  1
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