Vadivel Ganapathy - Publications

Affiliations: 
Medical College of Georgia, Augusta, GA, United States 
Area:
Molecular Biology, Biochemistry

127 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Chaudhary K, Chilakala A, Ananth S, Mandala A, Veeranan-Karmegam R, Powell FL, Ganapathy V, Gnana-Prakasam JP. Renal Iron Accelerates the Progression of Diabetic Nephropathy in HFE (High Fe-iron) Gene Knockout Mouse Model of Iron Overload. American Journal of Physiology. Renal Physiology. PMID 31188032 DOI: 10.1152/ajprenal.00184.2019  0.36
2019 Ogura J, Sato T, Higuchi K, Bhutia YD, Babu E, Masuda M, Miyauchi S, Rueda R, Pereira SL, Ganapathy V. Transport Mechanisms for the Nutritional Supplement β-Hydroxy-β-Methylbutyrate (HMB) in Mammalian Cells. Pharmaceutical Research. 36: 84. PMID 30997560 DOI: 10.1007/s11095-019-2626-3  0.48
2018 Sugio K, Inoda D, Masuda M, Azumaya I, Sasaki S, Shimono K, Ganapathy V, Miyauchi S. Transport of 2,4-dichloro phenoxyacetic acid by human Na-coupled monocarboxylate transporter 1 (hSMCT1, SLC5A8). Drug Metabolism and Pharmacokinetics. PMID 30583944 DOI: 10.1016/j.dmpk.2018.10.004  0.48
2018 Ogura J, Babu E, Miyauchi S, Ramachandran S, Nemeth E, Bhutia YD, Ganapathy V. Retraction Note: Identification of a novel Na-coupled Fe-citrate transport system, distinct from mammalian INDY, for uptake of citrate in mammalian cells. Scientific Reports. 8: 11021. PMID 30018353 DOI: 10.1038/s41598-018-28645-x  0.48
2018 Chaudhary K, Promsote W, Ananth S, Veeranan-Karmegam R, Tawfik A, Arjunan P, Martin P, Smith SB, Thangaraju M, Kisselev O, Ganapathy V, Gnana-Prakasam JP. Iron Overload Accelerates the Progression of Diabetic Retinopathy in Association with Increased Retinal Renin Expression. Scientific Reports. 8: 3025. PMID 29445185 DOI: 10.1038/s41598-018-21276-2  0.48
2018 Ogura J, Babu E, Miyauchi S, Ramachandran S, Nemeth E, Bhutia YD, Ganapathy V. Identification of a novel Na+-coupled Fe3+-citrate transport system, distinct from mammalian INDY, for uptake of citrate in mammalian cells. Scientific Reports. 8: 2519. PMID 29410496 DOI: 10.1038/s41598-018-20620-w  0.48
2018 Ranganathan P, Shanmugam A, Swafford D, Suryawanshi A, Bhattacharjee P, Hussein MS, Koni PA, Prasad PD, Kurago ZB, Thangaraju M, Ganapathy V, Manicassamy S. GPR81, a Cell-Surface Receptor for Lactate, Regulates Intestinal Homeostasis and Protects Mice from Experimental Colitis. Journal of Immunology (Baltimore, Md. : 1950). PMID 29386257 DOI: 10.4049/jimmunol.1700604  0.36
2017 Zhu X, Hu T, Ho MH, Wang Y, Yu M, Patel N, Pi W, Choi JH, Xu H, Kutlar F, Ganapathy V, Kutlar A, Tuan D. Hydroxyurea differentially modulates activator and repressors of γ-globin gene in erythroblasts of responsive and non-responsive patients with sickle cell disease in correlation with Index of Hydroxyurea Responsiveness. Haematologica. PMID 28971909 DOI: 10.3324/haematol.2017.175646  0.32
2017 Ogura J, Miyauchi S, Shimono K, Yang S, Gonchigar S, Ganapathy V, Bhutia YD. Carbidopa is an activator of aryl hydrocarbon receptor with potential for cancer therapy. The Biochemical Journal. 474: 3391-3402. PMID 28963435 DOI: 10.1042/BCJ20170583  0.48
2016 Promsote W, Powell FL, Veean S, Thounaojam M, Markand S, Saul A, Gutsaeva D, Bartoli M, Smith SB, Ganapathy V, Martin P. Oral monomethylfumarate therapy ameliorates retinopathy in a humanized mouse model of sickle cell disease. Antioxidants & Redox Signaling. PMID 27393735 DOI: 10.1089/ars.2016.6638  0.48
2016 Pathania R, Ramachandran S, Mariappan G, Thakur P, Shi H, Choi JH, Manicassamy S, Kolhe R, Prasad PD, Sharma S, Lokeshwar BL, Ganapathy V, Thangaraju M. Combined inhibition of DNMT and HDAC blocks the tumorigenicity of cancer stem-like cells and attenuates mammary tumor growth. Cancer Research. PMID 27197203 DOI: 10.1158/0008-5472.CAN-15-2249  0.36
2016 Arjunan P, Gnanaprakasam JP, Ananth S, Romej MA, Rajalakshmi VK, Prasad PD, Martin PM, Gurusamy M, Thangaraju M, Bhutia YD, Ganapathy V. Increased Retinal Expression of the Pro-Angiogenic Receptor GPR91 via BMP6 in a Mouse Model of Juvenile Hemochromatosis. Investigative Ophthalmology & Visual Science. 57: 1612-9. PMID 27046124 DOI: 10.1167/iovs.15-17437  0.36
2015 Bhutia YD, Ganapathy V. Glutamine transporters in mammalian cells and their functions in physiology and cancer. Biochimica Et Biophysica Acta. PMID 26724577 DOI: 10.1016/j.bbamcr.2015.12.017  0.48
2015 Shanmugam AK, Mysona BA, Wang J, Zhao J, Tawfik A, Sanders A, Markand S, Zorrilla E, Ganapathy V, Bollinger KE, Smith SB. Progesterone Receptor Membrane Component 1 (PGRMC1) Expression in Murine Retina. Current Eye Research. 1-8. PMID 26642738 DOI: 10.3109/02713683.2015.1085579  0.48
2015 Bhutia YD, Ganapathy V. Short, but Smart: SCFAs Train T Cells in the Gut to Fight Autoimmunity in the Brain. Immunity. 43: 629-31. PMID 26488813 DOI: 10.1016/j.immuni.2015.09.014  0.48
2015 Babu E, Bhutia YD, Ramachandran S, Gnanaprakasam JP, Prasad PD, Thangaraju M, Ganapathy V. Deletion of the amino acid transporter Slc6a14 suppresses tumour growth in spontaneous mouse models of breast cancer. The Biochemical Journal. 469: 17-23. PMID 26173258 DOI: 10.1042/BJ20150437  0.36
2015 Babu E, Bhutia YD, Ramachandran S, Gnana-Prakasam JP, Prasad PD, Thangaraju M, Ganapathy V. Deletion of the amino acid transporter Slc6a14 suppresses tumor growth in spontaneous mouse models of breast cancer. The Biochemical Journal. PMID 25967569 DOI: 10.1042/BJ20150437  0.48
2015 Wang J, Shanmugam A, Markand S, Zorrilla E, Ganapathy V, Smith SB. Sigma 1 receptor regulates the oxidative stress response in primary retinal Müller glial cells via NRF2 signaling and system xc(-), the Na(+)-independent glutamate-cystine exchanger. Free Radical Biology & Medicine. 86: 25-36. PMID 25920363 DOI: 10.1016/j.freeradbiomed.2015.04.009  0.48
2015 Pathania R, Ramachandran S, Elangovan S, Padia R, Yang P, Cinghu S, Veeranan-Karmegam R, Arjunan P, Gnana-Prakasam JP, Sadanand F, Pei L, Chang CS, Choi JH, Shi H, Manicassamy S, ... ... Ganapathy V, et al. DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis. Nature Communications. 6: 6910. PMID 25908435 DOI: 10.1038/ncomms7910  0.48
2015 Bhutia YD, Babu E, Ramachandran S, Ganapathy V. Amino Acid transporters in cancer and their relevance to "glutamine addiction": novel targets for the design of a new class of anticancer drugs. Cancer Research. 75: 1782-8. PMID 25855379 DOI: 10.1158/0008-5472.CAN-14-3745  0.48
2015 Markand S, Saul A, Roon P, Prasad P, Martin P, Rozen R, Ganapathy V, Smith SB. Retinal Ganglion Cell Loss and Mild Vasculopathy in Methylene Tetrahydrofolate Reductase (Mthfr)-Deficient Mice: A Model of Mild Hyperhomocysteinemia. Investigative Ophthalmology & Visual Science. 56: 2684-95. PMID 25766590 DOI: 10.1167/iovs.14-16190  0.48
2015 Bardhan K, Paschall AV, Yang D, Chen MR, Simon PS, Bhutia YD, Martin PM, Thangaraju M, Browning DD, Ganapathy V, Heaton CM, Gu K, Lee JR, Liu K. IFNγ Induces DNA Methylation-Silenced GPR109A Expression via pSTAT1/p300 and H3K18 Acetylation in Colon Cancer. Cancer Immunology Research. 3: 795-805. PMID 25735954 DOI: 10.1158/2326-6066.CIR-14-0164  0.48
2015 Gopal E, Babu E, Ramachandran S, Bhutia YD, Prasad PD, Ganapathy V. Species-specific influence of lithium on the activity of SLC13A5 (NaCT): lithium-induced activation is specific for the transporter in primates. The Journal of Pharmacology and Experimental Therapeutics. 353: 17-26. PMID 25617245 DOI: 10.1124/jpet.114.221523  0.48
2014 Shanmugam A, Wang J, Markand S, Perry RL, Tawfik A, Zorrilla E, Ganapathy V, Smith SB. Sigma receptor 1 activation attenuates release of inflammatory cytokines MIP1γ, MIP2, MIP3α, and IL12 (p40/p70) by retinal Müller glial cells. Journal of Neurochemistry. PMID 25439327 DOI: 10.1111/jnc.13002  0.48
2014 Tawfik A, Markand S, Al-Shabrawey M, Mayo JN, Reynolds J, Bearden SE, Ganapathy V, Smith SB. Alterations of retinal vasculature in cystathionine-β-synthase heterozygous mice: a model of mild to moderate hyperhomocysteinemia. The American Journal of Pathology. 184: 2573-85. PMID 25016930 DOI: 10.1016/j.ajpath.2014.05.018  0.48
2014 Promsote W, Makala L, Li B, Smith SB, Singh N, Ganapathy V, Pace BS, Martin PM. Monomethylfumarate induces γ-globin expression and fetal hemoglobin production in cultured human retinal pigment epithelial (RPE) and erythroid cells, and in intact retina. Investigative Ophthalmology & Visual Science. 55: 5382-93. PMID 24825111 DOI: 10.1167/iovs.14-14179  0.48
2014 Tawfik A, Gnana-Prakasam JP, Smith SB, Ganapathy V. Deletion of hemojuvelin, an iron-regulatory protein, in mice results in abnormal angiogenesis and vasculogenesis in retina along with reactive gliosis. Investigative Ophthalmology & Visual Science. 55: 3616-25. PMID 24812553 DOI: 10.1167/iovs.13-13677  0.48
2014 Gnana-Prakasam JP, Baldowski RB, Ananth S, Martin PM, Smith SB, Ganapathy V. Retinal expression of the serine protease matriptase-2 (Tmprss6) and its role in retinal iron homeostasis. Molecular Vision. 20: 561-74. PMID 24791141  0.48
2014 Ha Y, Shanmugam AK, Markand S, Zorrilla E, Ganapathy V, Smith SB. Sigma receptor 1 modulates ER stress and Bcl2 in murine retina. Cell and Tissue Research. 356: 15-27. PMID 24469320 DOI: 10.1007/s00441-013-1774-8  0.48
2014 Ananth S, Gnana-Prakasam JP, Bhutia YD, Veeranan-Karmegam R, Martin PM, Smith SB, Ganapathy V. Regulation of the cholesterol efflux transporters ABCA1 and ABCG1 in retina in hemochromatosis and by the endogenous siderophore 2,5-dihydroxybenzoic acid. Biochimica Et Biophysica Acta. 1842: 603-12. PMID 24462739 DOI: 10.1016/j.bbadis.2014.01.010  0.48
2014 Promsote W, Veeranan-Karmegam R, Ananth S, Shen D, Chan CC, Lambert NA, Ganapathy V, Martin PM. L-2-oxothiazolidine-4-carboxylic acid attenuates oxidative stress and inflammation in retinal pigment epithelium. Molecular Vision. 20: 73-88. PMID 24426777  0.48
2014 Singh N, Gurav A, Sivaprakasam S, Brady E, Padia R, Shi H, Thangaraju M, Prasad PD, Manicassamy S, Munn DH, Lee JR, Offermanns S, Ganapathy V. Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis. Immunity. 40: 128-39. PMID 24412617 DOI: 10.1016/j.immuni.2013.12.007  0.48
2014 Blackburn AR, Hamrick MW, Chutkan N, Sangani R, Waller JL, Corpe R, Prasad PD, Isales CM, Ganapathy V, Fulzele S. Comparative analysis of sodium coupled vitamin C transporter 2 in human osteoarthritis grade 1 and grade 3 tissues. Bmc Musculoskeletal Disorders. 15: 9. PMID 24401033 DOI: 10.1186/1471-2474-15-9  0.48
2014 Elangovan S, Pathania R, Ramachandran S, Ananth S, Padia RN, Lan L, Singh N, Martin PM, Hawthorn L, Prasad PD, Ganapathy V, Thangaraju M. The niacin/butyrate receptor GPR109A suppresses mammary tumorigenesis by inhibiting cell survival. Cancer Research. 74: 1166-78. PMID 24371223 DOI: 10.1158/0008-5472.CAN-13-1451  0.36
2013 Peden AS, Mac P, Fei YJ, Castro C, Jiang G, Murfitt KJ, Miska EA, Griffin JL, Ganapathy V, Jorgensen EM. Betaine acts on a ligand-gated ion channel in the nervous system of the nematode C. elegans. Nature Neuroscience. 16: 1794-801. PMID 24212673 DOI: 10.1038/nn.3575  0.48
2013 Ganapathy V, Thangaraju M, Prasad PD, Martin PM, Singh N. Transporters and receptors for short-chain fatty acids as the molecular link between colonic bacteria and the host. Current Opinion in Pharmacology. 13: 869-74. PMID 23978504 DOI: 10.1016/j.coph.2013.08.006  0.48
2013 Elangovan S, Pathania R, Ramachandran S, Ananth S, Padia RN, Srinivas SR, Babu E, Hawthorn L, Schoenlein PV, Boettger T, Smith SB, Prasad PD, Ganapathy V, Thangaraju M. Molecular mechanism of SLC5A8 inactivation in breast cancer. Molecular and Cellular Biology. 33: 3920-35. PMID 23918800 DOI: 10.1128/MCB.01702-12  0.48
2013 Sreekumar PG, Chothe P, Sharma KK, Baid R, Kompella U, Spee C, Kannan N, Manh C, Ryan SJ, Ganapathy V, Kannan R, Hinton DR. Antiapoptotic properties of α-crystallin-derived peptide chaperones and characterization of their uptake transporters in human RPE cells. Investigative Ophthalmology & Visual Science. 54: 2787-98. PMID 23532520 DOI: 10.1167/iovs.12-11571  0.48
2013 Markand S, Tawfik A, Ha Y, Gnana-Prakasam J, Sonne S, Ganapathy V, Sen N, Xian M, Smith SB. Cystathionine beta synthase expression in mouse retina. Current Eye Research. 38: 597-604. PMID 23470016 DOI: 10.3109/02713683.2013.774024  0.48
2013 Chothe PP, Chutkan N, Sangani R, Wenger KH, Prasad PD, Thangaraju M, Hamrick MW, Isales CM, Ganapathy V, Fulzele S. Sodium-coupled vitamin C transporter (SVCT2): expression, function, and regulation in intervertebral disc cells. The Spine Journal : Official Journal of the North American Spine Society. 13: 549-57. PMID 23415019 DOI: 10.1016/j.spinee.2013.01.022  0.48
2013 Tawfik A, Al-Shabrawey M, Roon P, Sonne S, Covar JA, Matragoon S, Ganapathy PS, Atherton SS, El-Remessy A, Ganapathy V, Smith SB. Alterations of retinal vasculature in cystathionine-Beta-synthase mutant mice, a model of hyperhomocysteinemia. Investigative Ophthalmology & Visual Science. 54: 939-49. PMID 23307965 DOI: 10.1167/iovs.12-10536  0.48
2013 Gnana-Prakasam JP, Veeranan-Karmegam R, Coothankandaswamy V, Reddy SK, Martin PM, Thangaraju M, Smith SB, Ganapathy V. Loss of Hfe leads to progression of tumor phenotype in primary retinal pigment epithelial cells. Investigative Ophthalmology & Visual Science. 54: 63-71. PMID 23169885 DOI: 10.1167/iovs.12-10312  0.48
2013 Coothankandaswamy V, Elangovan S, Singh N, Prasad PD, Thangaraju M, Ganapathy V. The plasma membrane transporter SLC5A8 suppresses tumour progression through depletion of survivin without involving its transport function. The Biochemical Journal. 450: 169-78. PMID 23167260 DOI: 10.1042/BJ20121248  0.48
2013 Fulzele S, Chothe P, Sangani R, Chutkan N, Hamrick M, Bhattacharyya M, Prasad PD, Zakhary I, Bowser M, Isales C, Ganapathy V. Sodium-dependent vitamin C transporter SVCT2: expression and function in bone marrow stromal cells and in osteogenesis. Stem Cell Research. 10: 36-47. PMID 23089627 DOI: 10.1016/j.scr.2012.08.004  0.48
2013 Shekhawat PS, Sonne S, Carter AL, Matern D, Ganapathy V. Enzymes involved in L-carnitine biosynthesis are expressed by small intestinal enterocytes in mice: implications for gut health. Journal of Crohn's & Colitis. 7: e197-205. PMID 22999781 DOI: 10.1016/j.crohns.2012.08.011  0.48
2013 Lewerenz J, Hewett SJ, Huang Y, Lambros M, Gout PW, Kalivas PW, Massie A, Smolders I, Methner A, Pergande M, Smith SB, Ganapathy V, Maher P. The cystine/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities. Antioxidants & Redox Signaling. 18: 522-55. PMID 22667998 DOI: 10.1089/ars.2011.4391  0.48
2012 Ha Y, Saul A, Tawfik A, Zorrilla EP, Ganapathy V, Smith SB. Diabetes accelerates retinal ganglion cell dysfunction in mice lacking sigma receptor 1. Molecular Vision. 18: 2860-70. PMID 23233788  0.48
2012 Sonne S, Shekhawat PS, Matern D, Ganapathy V, Ignatowicz L. Carnitine deficiency in OCTN2-/- newborn mice leads to a severe gut and immune phenotype with widespread atrophy, apoptosis and a pro-inflammatory response. Plos One. 7: e47729. PMID 23112839 DOI: 10.1371/journal.pone.0047729  0.36
2012 Liu F, Bardhan K, Yang D, Thangaraju M, Ganapathy V, Waller JL, Liles GB, Lee JR, Liu K. NF-κB directly regulates Fas transcription to modulate Fas-mediated apoptosis and tumor suppression. The Journal of Biological Chemistry. 287: 25530-40. PMID 22669972 DOI: 10.1074/jbc.M112.356279  0.48
2012 Zimmerman MA, Singh N, Martin PM, Thangaraju M, Ganapathy V, Waller JL, Shi H, Robertson KD, Munn DH, Liu K. Butyrate suppresses colonic inflammation through HDAC1-dependent Fas upregulation and Fas-mediated apoptosis of T cells. American Journal of Physiology. Gastrointestinal and Liver Physiology. 302: G1405-15. PMID 22517765 DOI: 10.1152/ajpgi.00543.2011  0.48
2012 Helm J, Coppola D, Ganapathy V, Lloyd M, Centeno BA, Chen DT, Malafa MP, Park JY. SLC5A8 nuclear translocation and loss of expression are associated with poor outcome in pancreatic ductal adenocarcinoma. Pancreas. 41: 904-9. PMID 22450368 DOI: 10.1097/MPA.0b013e31823f429f  0.48
2012 Gambhir D, Ananth S, Veeranan-Karmegam R, Elangovan S, Hester S, Jennings E, Offermanns S, Nussbaum JJ, Smith SB, Thangaraju M, Ganapathy V, Martin PM. GPR109A as an anti-inflammatory receptor in retinal pigment epithelial cells and its relevance to diabetic retinopathy. Investigative Ophthalmology & Visual Science. 53: 2208-17. PMID 22427566 DOI: 10.1167/iovs.11-8447  0.48
2012 Bozard BR, Chothe PP, Tawfik A, Williams C, Fulzele S, Prasad PD, Martin PM, Ganapathy V, Smith SB. Regulation of proton-coupled folate transporter in retinal Müller cells by the antipsoriatic drug monomethylfumarate. Glia. 60: 333-42. PMID 22072423 DOI: 10.1002/glia.22266  0.48
2012 Gnana-Prakasam JP, Tawfik A, Romej M, Ananth S, Martin PM, Smith SB, Ganapathy V. Iron-mediated retinal degeneration in haemojuvelin-knockout mice. The Biochemical Journal. 441: 599-608. PMID 21943374 DOI: 10.1042/BJ20111148  0.48
2012 Ananth S, Thakkar SV, Gnana-Prakasam JP, Martin PM, Ganapathy PS, Smith SB, Ganapathy V. Transport of the synthetic opioid peptide DADLE ([D-Ala2,D-Leu5]-enkephalin) in neuronal cells. Journal of Pharmaceutical Sciences. 101: 154-63. PMID 21905028 DOI: 10.1002/jps.22733  0.48
2011 Gnana-Prakasam JP, Reddy SK, Veeranan-Karmegam R, Smith SB, Martin PM, Ganapathy V. Polarized distribution of heme transporters in retinal pigment epithelium and their regulation in the iron-overload disease hemochromatosis. Investigative Ophthalmology & Visual Science. 52: 9279-86. PMID 22058337 DOI: 10.1167/iovs.11-8264  0.48
2011 Elangovan S, Ramachandran S, Venkatesan N, Ananth S, Gnana-Prakasam JP, Martin PM, Browning DD, Schoenlein PV, Prasad PD, Ganapathy V, Thangaraju M. SIRT1 is essential for oncogenic signaling by estrogen/estrogen receptor α in breast cancer. Cancer Research. 71: 6654-64. PMID 21920899 DOI: 10.1158/0008-5472.CAN-11-1446  0.48
2011 Ha Y, Saul A, Tawfik A, Williams C, Bollinger K, Smith R, Tachikawa M, Zorrilla E, Ganapathy V, Smith SB. Late-onset inner retinal dysfunction in mice lacking sigma receptor 1 (σR1). Investigative Ophthalmology & Visual Science. 52: 7749-60. PMID 21862648 DOI: 10.1167/iovs.11-8169  0.48
2011 Karunakaran S, Ramachandran S, Coothankandaswamy V, Elangovan S, Babu E, Periyasamy-Thandavan S, Gurav A, Gnanaprakasam JP, Singh N, Schoenlein PV, Prasad PD, Thangaraju M, Ganapathy V. SLC6A14 (ATB0,+) protein, a highly concentrative and broad specific amino acid transporter, is a novel and effective drug target for treatment of estrogen receptor-positive breast cancer. The Journal of Biological Chemistry. 286: 31830-8. PMID 21771784 DOI: 10.1074/jbc.M111.229518  0.48
2011 Tachikawa M, Murakami K, Martin PM, Hosoya K, Ganapathy V. Retinal transfer of nicotinate by H+ -monocarboxylate transporter at the inner blood-retinal barrier. Microvascular Research. 82: 385-90. PMID 21741392 DOI: 10.1016/j.mvr.2011.06.009  0.36
2011 Babu E, Ananth S, Veeranan-Karmegam R, Coothankandaswamy V, Smith SB, Boettger T, Ganapathy V, Martin PM. Transport via SLC5A8 (SMCT1) is obligatory for 2-oxothiazolidine-4-carboxylate to enhance glutathione production in retinal pigment epithelial cells. Investigative Ophthalmology & Visual Science. 52: 5749-57. PMID 21508099 DOI: 10.1167/iovs.10-6825  0.48
2011 Li HM, Zhang M, Xu ST, Li DZ, Zhu LY, Peng SW, Chen GQ, Martin PM, Ganapathy V, Wei CJ. Nicotinic acid inhibits glucose-stimulated insulin secretion via the G protein-coupled receptor PUMA-G in murine islet β cells. Pancreas. 40: 615-21. PMID 21441844 DOI: 10.1097/MPA.0b013e31820b4b23  0.36
2011 Gnana-Prakasam JP, Ananth S, Prasad PD, Zhang M, Atherton SS, Martin PM, Smith SB, Ganapathy V. Expression and iron-dependent regulation of succinate receptor GPR91 in retinal pigment epithelium. Investigative Ophthalmology & Visual Science. 52: 3751-8. PMID 21357408 DOI: 10.1167/iovs.10-6722  0.48
2011 Chothe PP, Gnana-Prakasam JP, Ananth S, Martin PM, Kannan R, Hinton DR, Smith SB, Ganapathy V. Transport of hepcidin, an iron-regulatory peptide hormone, into retinal pigment epithelial cells via oligopeptide transporters and its relevance to iron homeostasis. Biochemical and Biophysical Research Communications. 405: 244-9. PMID 21219868 DOI: 10.1016/j.bbrc.2011.01.018  0.48
2011 Ganapathy V. Drugs of abuse and human placenta. Life Sciences. 88: 926-30. PMID 20932493 DOI: 10.1016/j.lfs.2010.09.015  0.48
2011 Ha Y, Dun Y, Thangaraju M, Duplantier J, Dong Z, Liu K, Ganapathy V, Smith SB. Sigma receptor 1 modulates endoplasmic reticulum stress in retinal neurons. Investigative Ophthalmology & Visual Science. 52: 527-40. PMID 20811050 DOI: 10.1167/iovs.10-5731  0.48
2010 Li Y, Zhang M, Chen H, Dong Z, Ganapathy V, Thangaraju M, Huang S. Ratio of miR-196s to HOXC8 messenger RNA correlates with breast cancer cell migration and metastasis Cancer Research. 70: 7894-7904. PMID 20736365 DOI: 10.1158/0008-5472.CAN-10-1675  0.48
2010 Singh N, Thangaraju M, Prasad PD, Martin PM, Lambert NA, Boettger T, Offermanns S, Ganapathy V. Blockade of dendritic cell development by bacterial fermentation products butyrate and propionate through a transporter (Slc5a8)-dependent inhibition of histone deacetylases. The Journal of Biological Chemistry. 285: 27601-8. PMID 20601425 DOI: 10.1074/jbc.M110.102947  0.48
2010 Mazurek MP, Prasad PD, Gopal E, Fraser SP, Bolt L, Rizaner N, Palmer CP, Foster CS, Palmieri F, Ganapathy V, Stühmer W, Djamgoz MB, Mycielska ME. Molecular origin of plasma membrane citrate transporter in human prostate epithelial cells. Embo Reports. 11: 431-7. PMID 20448665 DOI: 10.1038/embor.2010.51  0.48
2010 Gnana-Prakasam JP, Martin PM, Smith SB, Ganapathy V. Expression and function of iron-regulatory proteins in retina. Iubmb Life. 62: 363-70. PMID 20408179 DOI: 10.1002/iub.326  0.48
2010 Becker HM, Mohebbi N, Perna A, Ganapathy V, Capasso G, Wagner CA. Localization of members of MCT monocarboxylate transporter family Slc16 in the kidney and regulation during metabolic acidosis. American Journal of Physiology. Renal Physiology. 299: F141-54. PMID 20392797 DOI: 10.1152/ajprenal.00488.2009  0.48
2010 Miyauchi S, Gopal E, Babu E, Srinivas SR, Kubo Y, Umapathy NS, Thakkar SV, Ganapathy V, Prasad PD. Sodium-coupled electrogenic transport of pyroglutamate (5-oxoproline) via SLC5A8, a monocarboxylate transporter. Biochimica Et Biophysica Acta. 1798: 1164-71. PMID 20211600 DOI: 10.1016/j.bbamem.2010.03.002  0.48
2010 Ananth S, Zhuang L, Gopal E, Itagaki S, Ellappan B, Smith SB, Ganapathy V, Martin P. Diclofenac-induced stimulation of SMCT1 (SLC5A8) in a heterologous expression system: a RPE specific phenomenon. Biochemical and Biophysical Research Communications. 394: 75-80. PMID 20178774 DOI: 10.1016/j.bbrc.2010.02.109  0.48
2010 Periyasamy-Thandavan S, Jackson WH, Samaddar JS, Erickson B, Barrett JR, Raney L, Gopal E, Ganapathy V, Hill WD, Bhalla KN, Schoenlein PV. Bortezomib blocks the catabolic process of autophagy via a cathepsin-dependent mechanism, affects endoplasmic reticulum stress and induces caspase-dependent cell death in antiestrogen-sensitive and resistant ER+ breast cancer cells. Autophagy. 6: 19-35. PMID 20110775 DOI: 10.4161/auto.6.1.10323  0.48
2010 Bozard BR, Ganapathy PS, Duplantier J, Mysona B, Ha Y, Roon P, Smith R, Goldman ID, Prasad P, Martin PM, Ganapathy V, Smith SB. Molecular and biochemical characterization of folate transport proteins in retinal Müller cells. Investigative Ophthalmology & Visual Science. 51: 3226-35. PMID 20053979 DOI: 10.1167/iovs.09-4833  0.48
2010 Chothe PP, Thakkar SV, Gnana-Prakasam JP, Ananth S, Hinton DR, Kannan R, Smith SB, Martin PM, Ganapathy V. Identification of a novel sodium-coupled oligopeptide transporter (SOPT2) in mouse and human retinal pigment epithelial cells. Investigative Ophthalmology & Visual Science. 51: 413-20. PMID 19643969 DOI: 10.1167/iovs.09-4048  0.48
2009 Gnana-Prakasam JP, Thangaraju M, Liu K, Ha Y, Martin PM, Smith SB, Ganapathy V. Absence of iron-regulatory protein Hfe results in hyperproliferation of retinal pigment epithelium: role of cystine/glutamate exchanger. The Biochemical Journal. 424: 243-52. PMID 19715555 DOI: 10.1042/BJ20090424  0.48
2009 Thangaraju M, Karunakaran SK, Itagaki S, Gopal E, Elangovan S, Prasad PD, Ganapathy V. Transport by SLC5A8 with subsequent inhibition of histone deacetylase 1 (HDAC1) and HDAC3 underlies the antitumor activity of 3-bromopyruvate. Cancer. 115: 4655-66. PMID 19637353 DOI: 10.1002/cncr.24532  0.48
2009 Thangaraju M, Cresci GA, Liu K, Ananth S, Gnanaprakasam JP, Browning DD, Mellinger JD, Smith SB, Digby GJ, Lambert NA, Prasad PD, Ganapathy V. GPR109A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon. Cancer Research. 69: 2826-32. PMID 19276343 DOI: 10.1158/0008-5472.CAN-08-4466  0.48
2009 Martin PM, Ananth S, Cresci G, Roon P, Smith S, Ganapathy V. Expression and localization of GPR109A (PUMA-G/HM74A) mRNA and protein in mammalian retinal pigment epithelium. Molecular Vision. 15: 362-72. PMID 19223991  0.36
2009 Gnana-Prakasam JP, Zhang M, Martin PM, Atherton SS, Smith SB, Ganapathy V. Expression of the iron-regulatory protein haemojuvelin in retina and its regulation during cytomegalovirus infection. The Biochemical Journal. 419: 533-43. PMID 19191760 DOI: 10.1042/BJ20082240  0.48
2009 Mysona B, Dun Y, Duplantier J, Ganapathy V, Smith SB. Effects of hyperglycemia and oxidative stress on the glutamate transporters GLAST and system xc- in mouse retinal Müller glial cells. Cell and Tissue Research. 335: 477-88. PMID 19156441 DOI: 10.1007/s00441-008-0742-1  0.48
2009 Ganapathy V. A traffic signal for heterodimeric amino acid transporters to transfer from the ER to the Golgi. The Biochemical Journal. 417: e9-11. PMID 19099537 DOI: 10.1042/BJ20082246  0.48
2009 Ganapathy V, Thangaraju M, Prasad PD. Nutrient transporters in cancer: relevance to Warburg hypothesis and beyond. Pharmacology & Therapeutics. 121: 29-40. PMID 18992769 DOI: 10.1016/j.pharmthera.2008.09.005  0.36
2009 Thangaraju M, Carswell KN, Prasad PD, Ganapathy V. Colon cancer cells maintain low levels of pyruvate to avoid cell death caused by inhibition of HDAC1/HDAC3. The Biochemical Journal. 417: 379-89. PMID 18789002 DOI: 10.1042/BJ20081132  0.36
2009 Ananth S, Karunakaran S, Martin PM, Nagineni CN, Hooks JJ, Smith SB, Prasad PD, Ganapathy V. Functional identification of a novel transport system for endogenous and synthetic opioid peptides in the rabbit conjunctival epithelial cell line CJVE. Pharmaceutical Research. 26: 1226-35. PMID 18781380 DOI: 10.1007/s11095-008-9709-x  0.48
2008 Thakkar SV, Miyauchi S, Prasad PD, Ganapathy V. Stimulation of Na+/Cl--coupled opioid peptide transport system in SK-N-SH cells by L-kyotorphin, an endogenous substrate for H+-coupled peptide transporter PEPT2. Drug Metabolism and Pharmacokinetics. 23: 254-62. PMID 18762712 DOI: JST.JSTAGE/dmpk/23.254  0.48
2008 Umapathy NS, Dun Y, Martin PM, Duplantier JN, Roon P, Prasad P, Smith SB, Ganapathy V. Expression and function of system N glutamine transporters (SN1/SN2 or SNAT3/SNAT5) in retinal ganglion cells. Investigative Ophthalmology & Visual Science. 49: 5151-60. PMID 18689705 DOI: 10.1167/iovs.08-2245  0.48
2008 Thangaraju M, Cresci G, Itagaki S, Mellinger J, Browning DD, Berger FG, Prasad PD, Ganapathy V. Sodium-coupled transport of the short chain fatty acid butyrate by SLC5A8 and its relevance to colon cancer. Journal of Gastrointestinal Surgery : Official Journal of the Society For Surgery of the Alimentary Tract. 12: 1773-81; discussion . PMID 18661192 DOI: 10.1007/s11605-008-0573-0  0.36
2008 Karunakaran S, Umapathy NS, Thangaraju M, Hatanaka T, Itagaki S, Munn DH, Prasad PD, Ganapathy V. Interaction of tryptophan derivatives with SLC6A14 (ATB0,+) reveals the potential of the transporter as a drug target for cancer chemotherapy. The Biochemical Journal. 414: 343-55. PMID 18522536 DOI: 10.1042/BJ20080622  0.48
2008 Smith SB, Duplantier J, Dun Y, Mysona B, Roon P, Martin PM, Ganapathy V. In vivo protection against retinal neurodegeneration by sigma receptor 1 ligand (+)-pentazocine. Investigative Ophthalmology & Visual Science. 49: 4154-61. PMID 18469181 DOI: 10.1167/iovs.08-1824  0.48
2008 Ganapathy V, Thangaraju M, Gopal E, Martin PM, Itagaki S, Miyauchi S, Prasad PD. Sodium-coupled monocarboxylate transporters in normal tissues and in cancer. The Aaps Journal. 10: 193-9. PMID 18446519 DOI: 10.1208/s12248-008-9022-y  0.48
2008 Kozlowski DJ, Chen Z, Zhuang L, Fei YJ, Navarre S, Ganapathy V. Molecular characterization and expression pattern of taurine transporter in zebrafish during embryogenesis. Life Sciences. 82: 1004-11. PMID 18407297 DOI: 10.1016/j.lfs.2008.02.015  0.48
2008 Talukder JR, Kekuda R, Saha P, Prasad PD, Ganapathy V, Sundaram U. Functional characterization, localization, and molecular identification of rabbit intestinal N-amino acid transporter. American Journal of Physiology. Gastrointestinal and Liver Physiology. 294: G1301-10. PMID 18388187 DOI: 10.1152/ajpgi.00578.2007  0.36
2008 Gnana-Prakasam JP, Martin PM, Mysona BA, Roon P, Smith SB, Ganapathy V. Hepcidin expression in mouse retina and its regulation via lipopolysaccharide/Toll-like receptor-4 pathway independent of Hfe. The Biochemical Journal. 411: 79-88. PMID 18042040 DOI: 10.1042/BJ20071377  0.48
2008 Dun Y, Duplantier J, Roon P, Martin PM, Ganapathy V, Smith SB. Serine racemase expression and D-serine content are developmentally regulated in neuronal ganglion cells of the retina. Journal of Neurochemistry. 104: 970-8. PMID 17976164 DOI: 10.1111/j.1471-4159.2007.05015.x  0.48
2007 Umapathy NS, Gnana-Prakasam JP, Martin PM, Mysona B, Dun Y, Smith SB, Ganapathy V, Prasad PD. Cloning and functional characterization of the proton-coupled electrogenic folate transporter and analysis of its expression in retinal cell types. Investigative Ophthalmology & Visual Science. 48: 5299-305. PMID 17962486 DOI: 10.1167/iovs.07-0288  0.48
2007 Dun Y, Thangaraju M, Prasad P, Ganapathy V, Smith SB. Prevention of excitotoxicity in primary retinal ganglion cells by (+)-pentazocine, a sigma receptor-1 specific ligand. Investigative Ophthalmology & Visual Science. 48: 4785-94. PMID 17898305 DOI: 10.1167/iovs.07-0343  0.48
2007 Shekhawat PS, Srinivas SR, Matern D, Bennett MJ, Boriack R, George V, Xu H, Prasad PD, Roon P, Ganapathy V. Spontaneous development of intestinal and colonic atrophy and inflammation in the carnitine-deficient jvs (OCTN2(-/-)) mice. Molecular Genetics and Metabolism. 92: 315-24. PMID 17884651 DOI: 10.1016/j.ymgme.2007.08.002  0.36
2007 Srinivas SR, Prasad PD, Umapathy NS, Ganapathy V, Shekhawat PS. Transport of butyryl-L-carnitine, a potential prodrug, via the carnitine transporter OCTN2 and the amino acid transporter ATB(0,+). American Journal of Physiology. Gastrointestinal and Liver Physiology. 293: G1046-53. PMID 17855766 DOI: 10.1152/ajpgi.00233.2007  0.36
2007 Gopal E, Umapathy NS, Martin PM, Ananth S, Gnana-Prakasam JP, Becker H, Wagner CA, Ganapathy V, Prasad PD. Cloning and functional characterization of human SMCT2 (SLC5A12) and expression pattern of the transporter in kidney. Biochimica Et Biophysica Acta. 1768: 2690-7. PMID 17692818 DOI: 10.1016/j.bbamem.2007.06.031  0.48
2007 Martin PM, Dun Y, Mysona B, Ananth S, Roon P, Smith SB, Ganapathy V. Expression of the sodium-coupled monocarboxylate transporters SMCT1 (SLC5A8) and SMCT2 (SLC5A12) in retina. Investigative Ophthalmology & Visual Science. 48: 3356-63. PMID 17591909 DOI: 10.1167/iovs.06-0888  0.48
2007 Takekuma Y, Kakiuchi H, Yamazaki K, Miyauchi S, Kikukawa T, Kamo N, Ganapathy V, Sugawara M. Difference between pharmacokinetics of mycophenolic acid (MPA) in rats and that in humans is caused by different affinities of MRP2 to a glucuronized form. Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society For Pharmaceutical Sciences, SociéTé Canadienne Des Sciences Pharmaceutiques. 10: 71-85. PMID 17498396  0.48
2007 Makrides V, Bauer R, Weber W, Wester HJ, Fischer S, Hinz R, Huggel K, Opfermann T, Herzau M, Ganapathy V, Verrey F, Brust P. Preferred transport of O-(2-[18F]fluoroethyl)-D-tyrosine (D-FET) into the porcine brain. Brain Research. 1147: 25-33. PMID 17343835 DOI: 10.1016/j.brainres.2007.02.008  0.48
2007 Miyauchi S, Gopal E, Thakkar SV, Ichikawa S, Prasad PD, Ganapathy V. Differential modulation of sodium- and chloride-dependent opioid peptide transport system by small nonopioid peptides and free amino acids Journal of Pharmacology and Experimental Therapeutics. 321: 257-264. PMID 17259448 DOI: 10.1124/jpet.106.116806  0.48
2007 Gopal E, Miyauchi S, Martin PM, Ananth S, Roon P, Smith SB, Ganapathy V. Transport of nicotinate and structurally related compounds by human SMCT1 (SLC5A8) and its relevance to drug transport in the mammalian intestinal tract. Pharmaceutical Research. 24: 575-84. PMID 17245649 DOI: 10.1007/s11095-006-9176-1  0.48
2007 Seki A, Miyauchi S, Hayashi S, Kikukawa T, Kubo M, Demura M, Ganapathy V, Kamo N. Heterologous expression of Pharaonis halorhodopsin in Xenopus laevis oocytes and electrophysiological characterization of its light-driven Cl- pump activity. Biophysical Journal. 92: 2559-69. PMID 17208978 DOI: 10.1529/biophysj.106.093153  0.48
2007 Gopal E, Miyauchi S, Martin PM, Ananth S, Srinivas SR, Smith SB, Prasad PD, Ganapathy V. Expression and functional features of NaCT, a sodium-coupled citrate transporter, in human and rat livers and cell lines. American Journal of Physiology. Gastrointestinal and Liver Physiology. 292: G402-8. PMID 16973915 DOI: 10.1152/ajpgi.00371.2006  0.48
2006 Thangaraju M, Gopal E, Martin PM, Ananth S, Smith SB, Prasad PD, Sterneck E, Ganapathy V. SLC5A8 triggers tumor cell apoptosis through pyruvate-dependent inhibition of histone deacetylases. Cancer Research. 66: 11560-4. PMID 17178845 DOI: 10.1158/0008-5472.CAN-06-1950  0.48
2006 Jiang G, Mysona B, Dun Y, Gnana-Prakasam JP, Pabla N, Li W, Dong Z, Ganapathy V, Smith SB. Expression, subcellular localization, and regulation of sigma receptor in retinal muller cells. Investigative Ophthalmology & Visual Science. 47: 5576-82. PMID 17122151 DOI: 10.1167/iovs.06-0608  0.48
2006 Martin PM, Gnana-Prakasam JP, Roon P, Smith RG, Smith SB, Ganapathy V. Expression and polarized localization of the hemochromatosis gene product HFE in retinal pigment epithelium. Investigative Ophthalmology & Visual Science. 47: 4238-44. PMID 17003411 DOI: 10.1167/iovs.06-0026  0.48
2006 Jansson N, Pettersson J, Haafiz A, Ericsson A, Palmberg I, Tranberg M, Ganapathy V, Powell TL, Jansson T. Down-regulation of placental transport of amino acids precedes the development of intrauterine growth restriction in rats fed a low protein diet. The Journal of Physiology. 576: 935-46. PMID 16916910 DOI: 10.1113/jphysiol.2006.116509  0.48
2006 Thangaraju M, Ananth S, Martin PM, Roon P, Smith SB, Sterneck E, Prasad PD, Ganapathy V. c/ebpdelta Null mouse as a model for the double knock-out of slc5a8 and slc5a12 in kidney. The Journal of Biological Chemistry. 281: 26769-73. PMID 16873376 DOI: 10.1074/jbc.C600189200  0.48
2006 Gupta N, Martin PM, Miyauchi S, Ananth S, Herdman AV, Martindale RG, Podolsky R, Ganapathy V. Down-regulation of BCRP/ABCG2 in colorectal and cervical cancer. Biochemical and Biophysical Research Communications. 343: 571-7. PMID 16554028 DOI: 10.1016/j.bbrc.2006.02.172  0.48
2006 Hu H, Endres CJ, Chang C, Umapathy NS, Lee EW, Fei YJ, Itagaki S, Swaan PW, Ganapathy V, Unadkat JD. Electrophysiological characterization and modeling of the structure activity relationship of the human concentrative nucleoside transporter 3 (hCNT3). Molecular Pharmacology. 69: 1542-53. PMID 16446384 DOI: 10.1124/mol.105.018945  0.48
2006 Gupta N, Martin PM, Prasad PD, Ganapathy V. SLC5A8 (SMCT1)-mediated transport of butyrate forms the basis for the tumor suppressive function of the transporter. Life Sciences. 78: 2419-25. PMID 16375929 DOI: 10.1016/j.lfs.2005.10.028  0.36
2006 Hou Y, Gupta N, Schoenlein P, Wong E, Martindale R, Ganapathy V, Browning D. An anti-tumor role for cGMP-dependent protein kinase. Cancer Letters. 240: 60-8. PMID 16256267 DOI: 10.1016/j.canlet.2005.08.035  0.36
2006 Gupta N, Prasad PD, Ghamande S, Moore-Martin P, Herdman AV, Martindale RG, Podolsky R, Mager S, Ganapathy ME, Ganapathy V. Up-regulation of the amino acid transporter ATB(0,+) (SLC6A14) in carcinoma of the cervix. Gynecologic Oncology. 100: 8-13. PMID 16168467 DOI: 10.1016/j.ygyno.2005.08.016  0.48
2005 Gupta N, Miyauchi S, Martindale RG, Herdman AV, Podolsky R, Miyake K, Mager S, Prasad PD, Ganapathy ME, Ganapathy V. Upregulation of the amino acid transporter ATB0,+ (SLC6A14) in colorectal cancer and metastasis in humans. Biochimica Et Biophysica Acta. 1741: 215-23. PMID 15905073 DOI: 10.1016/j.bbadis.2005.04.002  0.48
2005 Jiang G, Zhuang L, Miyauchi S, Miyake K, Fei YJ, Ganapathy V. A Na+/Cl- -coupled GABA transporter, GAT-1, from Caenorhabditis elegans: structural and functional features, specific expression in GABA-ergic neurons, and involvement in muscle function. The Journal of Biological Chemistry. 280: 2065-77. PMID 15542610 DOI: 10.1074/jbc.M408470200  0.48
2004 George RL, Huang W, Naggar HA, Smith SB, Ganapathy V. Transport of N-acetylaspartate via murine sodium/dicarboxylate cotransporter NaDC3 and expression of this transporter and aspartoacylase II in ocular tissues in mouse. Biochimica Et Biophysica Acta. 1690: 63-9. PMID 15337171 DOI: 10.1016/j.bbadis.2004.05.009  0.48
2004 Bridges CC, Hu H, Miyauchi S, Siddaramappa UN, Ganapathy ME, Ignatowicz L, Maddox DM, Smith SB, Ganapathy V. Induction of cystine-glutamate transporter xc- by human immunodeficiency virus type 1 transactivator protein tat in retinal pigment epithelium. Investigative Ophthalmology & Visual Science. 45: 2906-14. PMID 15326101 DOI: 10.1167/iovs.03-1355  0.48
2003 Hu H, Miyauchi S, Bridges CC, Smith SB, Ganapathy V. Identification of a novel Na+- and Cl--coupled transport system for endogenous opioid peptides in retinal pigment epithelium and induction of the transport system by HIV-1 Tat. The Biochemical Journal. 375: 17-22. PMID 12924983 DOI: 10.1042/BJ20031059  0.48
2001 Friedrich A, George RL, Bridges CC, Prasad PD, Ganapathy V. Transport of choline and its relationship to the expression of the organic cation transporters in a rat brain microvessel endothelial cell line (RBE4). Biochimica Et Biophysica Acta. 1512: 299-307. PMID 11406107 DOI: 10.1016/S0005-2736(01)00333-9  0.48
2000 Wu X, George RL, Huang W, Wang H, Conway SJ, Leibach FH, Ganapathy V. Structural and functional characteristics and tissue distribution pattern of rat OCTN1, an organic cation transporter, cloned from placenta. Biochimica Et Biophysica Acta. 1466: 315-27. PMID 10825452 DOI: 10.1016/S0005-2736(00)00189-9  0.48
2000 Rajan DP, Huang W, Kekuda R, George RL, Wang J, Conway SJ, Devoe LD, Leibach FH, Prasad PD, Ganapathy V. Differential influence of the 4F2 heavy chain and the protein related to b(0,+) amino acid transport on substrate affinity of the heteromeric b(0,+) amino acid transporter. The Journal of Biological Chemistry. 275: 14331-5. PMID 10799513 DOI: 10.1074/jbc.275.19.14331  0.48
1999 George RL, Wu X, Huang W, Fei YJ, Leibach FH, Ganapathy V. Molecular cloning and functional characterization of a polyspecific organic anion transporter from Caenorhabditis elegans. The Journal of Pharmacology and Experimental Therapeutics. 291: 596-603. PMID 10525077  0.48
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