| Year |
Citation |
Score |
| 2015 |
Jiao C, Summerlin M, Bruzik KS, Hanakahi L. Synthesis of Biotinylated Inositol Hexakisphosphate To Study DNA Double-Strand Break Repair and Affinity Capture of IP6-Binding Proteins. Biochemistry. 54: 6312-22. PMID 26397942 DOI: 10.1021/acs.biochem.5b00642 |
1 |
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| 2015 |
Desai R, Savechenkov PY, Zolkowska D, Ge RL, Rogawski MA, Bruzik KS, Forman SA, Raines DE, Miller KW. Contrasting actions of a convulsant barbiturate and its anti-convulsant enantiomer on the α1β3γ2L GABAA receptor account for their in vivo effects. The Journal of Physiology. PMID 26378885 DOI: 10.1113/JP270971 |
1 |
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| 2015 |
Jayakar SS, Zhou X, Savechenkov PY, Chiara DC, Desai R, Bruzik KS, Miller KW, Cohen JB. Positive and Negative Allosteric Modulation of an α1β3γ2 γ-Aminobutyric acid Type A (GABAA) Receptor by Binding to a Site in the Transmembrane Domain at the γ+-β- Interface. The Journal of Biological Chemistry. PMID 26229099 DOI: 10.1074/jbc.M115.672006 |
1 |
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| 2014 |
Jayakar SS, Zhou X, Chiara DC, Dostalova Z, Savechenkov PY, Bruzik KS, Dailey WP, Miller KW, Eckenhoff RG, Cohen JB. Multiple propofol-binding sites in a γ-aminobutyric acid type A receptor (GABAAR) identified using a photoreactive propofol analog. The Journal of Biological Chemistry. 289: 27456-68. PMID 25086038 DOI: 10.1074/jbc.M114.581728 |
1 |
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| 2014 |
Hamouda AK, Stewart DS, Chiara DC, Savechenkov PY, Bruzik KS, Cohen JB. Identifying barbiturate binding sites in a nicotinic acetylcholine receptor with [3H]allyl m-trifluoromethyldiazirine mephobarbital, a photoreactive barbiturate. Molecular Pharmacology. 85: 735-46. PMID 24563544 DOI: 10.1124/mol.113.090985 |
1 |
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| 2013 |
Chiara DC, Jayakar SS, Zhou X, Zhang X, Savechenkov PY, Bruzik KS, Miller KW, Cohen JB. Specificity of intersubunit general anesthetic-binding sites in the transmembrane domain of the human α1β3γ2 γ-aminobutyric acid type A (GABAA) receptor. The Journal of Biological Chemistry. 288: 19343-57. PMID 23677991 DOI: 10.1074/jbc.M113.479725 |
1 |
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| 2012 |
Shanmugasundararaj S, Das J, Sandberg WS, Zhou X, Wang D, Messing RO, Bruzik KS, Stehle T, Miller KW. Structural and functional characterization of an anesthetic binding site in the second cysteine-rich domain of protein kinase Cδ*. Biophysical Journal. 103: 2331-40. PMID 23283232 DOI: 10.1016/j.bpj.2012.10.034 |
1 |
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| 2012 |
Yue L, Pawlowski M, Dellal SS, Xie A, Feng F, Otis TS, Bruzik KS, Qian H, Pepperberg DR. Robust photoregulation of GABA(A) receptors by allosteric modulation with a propofol analogue. Nature Communications. 3: 1095. PMID 23033071 DOI: 10.1038/ncomms2094 |
1 |
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| 2012 |
Savechenkov PY, Zhang X, Chiara DC, Stewart DS, Ge R, Zhou X, Raines DE, Cohen JB, Forman SA, Miller KW, Bruzik KS. Allyl m-trifluoromethyldiazirine mephobarbital: an unusually potent enantioselective and photoreactive barbiturate general anesthetic. Journal of Medicinal Chemistry. 55: 6554-65. PMID 22734650 DOI: 10.1021/jm300631e |
1 |
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| 2011 |
Stewart DS, Savechenkov PY, Dostalova Z, Chiara DC, Ge R, Raines DE, Cohen JB, Forman SA, Bruzik KS, Miller KW. p-(4-Azipentyl)propofol: a potent photoreactive general anesthetic derivative of propofol. Journal of Medicinal Chemistry. 54: 8124-35. PMID 22029276 DOI: 10.1021/jm200943f |
1 |
|
| 2011 |
Yue L, Xie A, Bruzik KS, Frølund B, Qian H, Pepperberg DR. Potentiating action of propofol at GABAA receptors of retinal bipolar cells. Investigative Ophthalmology & Visual Science. 52: 2497-509. PMID 21071744 DOI: 10.1167/iovs.10-5991 |
1 |
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| 2010 |
Bai C, Zhao L, Tsai MD, Bruzik KS. Unique catalytic mechanism of phosphatidylinositol-specific phospholipase C from Streptomyces antibioticus. Journal of the American Chemical Society. 132: 1210-1. PMID 20052980 DOI: 10.1021/ja908285h |
1 |
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| 2010 |
Mihai C, Yue X, Zhao L, Kravchuk A, Tsai MD, Bruzik KS. Nonhydrolyzable analogs of phosphatidylinositol as ligands of phospholipases C New Journal of Chemistry. 34: 925-933. DOI: 10.1039/b9nj00629j |
1 |
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| 2009 |
Bai C, Zhao L, Rebecchi M, Tsai MD, Bruzik KS. Trans-cyclization of phosphatidylinositol catalyzed by phospholipase C from Streptomyces antibioticus. Journal of the American Chemical Society. 131: 8362-3. PMID 19492832 DOI: 10.1021/ja902326u |
1 |
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| 2007 |
Liu Y, Mihai C, Kubiak RJ, Rebecchi M, Bruzik KS. Phosphorothiolate analogues of phosphatidylinositols as assay substrates for phospholipase C. Chembiochem : a European Journal of Chemical Biology. 8: 1430-9. PMID 17659518 DOI: 10.1002/cbic.200700061 |
1 |
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| 2006 |
Stahelin RV, Karathanassis D, Bruzik KS, Waterfield MD, Bravo J, Williams RL, Cho W. Structural and membrane binding analysis of the Phox homology domain of phosphoinositide 3-kinase-C2alpha. The Journal of Biological Chemistry. 281: 39396-406. PMID 17038310 DOI: 10.1074/jbc.M607079200 |
1 |
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| 2004 |
Stahelin RV, Ananthanarayanan B, Blatner NR, Singh S, Bruzik KS, Murray D, Cho W. Mechanism of membrane binding of the phospholipase D1 PX domain. The Journal of Biological Chemistry. 279: 54918-26. PMID 15475361 DOI: 10.1074/jbc.M407798200 |
1 |
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| 2003 |
Liu Y, Bruzik KS, Ananthanarayanan B, Cho W. New aspects of formation of 1,2-cyclic phosphates by phospholipase C-delta1. Bioorganic & Medicinal Chemistry. 11: 2471-5. PMID 12735994 DOI: 10.1016/S0968-0896(03)00150-0 |
1 |
|
| 2003 |
Mihai C, Kravchuk AV, Tsai MD, Bruzik KS. Application of Brønsted-type LFER in the study of the phospholipase C mechanism. Journal of the American Chemical Society. 125: 3236-42. PMID 12630878 DOI: 10.1021/ja029362s |
1 |
|
| 2003 |
Kravchuk AV, Zhao L, Bruzik KS, Tsai MD. Engineering a catalytic metal binding site into a calcium-independent phosphatidylinositol-specific phospholipase C leads to enhanced stereoselectivity. Biochemistry. 42: 2422-30. PMID 12600209 DOI: 10.1021/bi0271953 |
1 |
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| 2003 |
Kubiak RJ, Bruzik KS. Comprehensive and uniform synthesis of all naturally occurring phosphorylated phosphatidylinositols. The Journal of Organic Chemistry. 68: 960-8. PMID 12558421 DOI: 10.1021/jo0206418 |
1 |
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| 2003 |
Stahelin RV, Burian A, Bruzik KS, Murray D, Cho W. Membrane binding mechanisms of the PX domains of NADPH oxidase p40phox and p47phox. The Journal of Biological Chemistry. 278: 14469-79. PMID 12556460 DOI: 10.1074/jbc.M212579200 |
1 |
|
| 2003 |
Zhao L, Liu Y, Bruzik KS, Tsai MD. A novel calcium-dependent bacterial phosphatidylinositol-specific phospholipase C displaying unprecedented magnitudes of thio effect, inverse thio effect, and stereoselectivity. Journal of the American Chemical Society. 125: 22-3. PMID 12515492 DOI: 10.1021/ja029019n |
1 |
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| 2002 |
Stahelin RV, Long F, Diraviyam K, Bruzik KS, Murray D, Cho W. Phosphatidylinositol 3-phosphate induces the membrane penetration of the FYVE domains of Vps27p and Hrs. The Journal of Biological Chemistry. 277: 26379-88. PMID 12006563 DOI: 10.1074/jbc.M201106200 |
1 |
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| 2001 |
Kravchuk AV, Zhao L, Kubiak RJ, Bruzik KS, Tsai MD. Mechanism of phosphatidylinositol-specific phospholipase C: origin of unusually high nonbridging thio effects. Biochemistry. 40: 5433-9. PMID 11331007 |
1 |
|
| 2001 |
Kubiak RJ, Yue X, Hondal RJ, Mihai C, Tsai MD, Bruzik KS. Involvement of the Arg-Asp-His catalytic triad in enzymatic cleavage of the phosphodiester bond. Biochemistry. 40: 5422-32. PMID 11331006 DOI: 10.1021/bi002371y |
1 |
|
| 2000 |
Hengge AC, Bruzik KS, Tobin AE, Cleland WW, Tsai MD. Kinetic Isotope Effects and Stereochemical Studies on a Ribonuclease Model: Hydrolysis Reactions of Uridine 3'-Nitrophenyl Phosphate. Bioorganic Chemistry. 28: 119-133. PMID 10915550 DOI: 10.1006/bioo.2000.1170 |
1 |
|
| 1999 |
Kubiak RJ, Hondal RJ, Yue X, Tsai MD, Bruzik KS. Identification of a novel catalytic triad with dual functions in enzymatic cleavage of the P-O bond Journal of the American Chemical Society. 121: 488-489. DOI: 10.1021/ja9834677 |
1 |
|
| 1999 |
Hondal RJ, Zhao Z, Kravchuk AV, Liao H, Riddle SR, Bruzik KS, Tsai MD. Mechanism of phosphatidylinositol-specific phospholipase C revealed by protein engineering and phosphorothioate analogs of phosphatidylinositol Acs Symposium Series. 718: 109-120. |
1 |
|
| 1998 |
Hondal RJ, Zhao Z, Kravchuk AV, Liao H, Riddle SR, Yue X, Bruzik KS, Tsai MD. Mechanism of phosphatidylinositol-specific phospholipase C: A unified view of the mechanism of catalysis Biochemistry. 37: 4568-4580. PMID 9521777 DOI: 10.1021/bi972646i |
1 |
|
| 1997 |
Hondal RJ, Riddle SR, Kravchuk AV, Zhao Z, Liao H, Bruzik KS, Tsai MD. Phosphatidylinositol-specific phospholipase C: Kinetic and stereochemical evidence for an interaction between arginine-69 and the phosphate group of phosphatidylinositol Biochemistry. 36: 6633-6642. PMID 9184143 DOI: 10.1021/bi962866g |
1 |
|
| 1997 |
Ho MW, Shears SB, Bruzik KS, Duszyk M, French AS. Ins(3,4,5,6)P4 specifically inhibits a receptor-mediated Ca2+-dependent Cl- current in CFPAC-1 cells. The American Journal of Physiology. 272: C1160-8. PMID 9142840 |
1 |
|
| 1997 |
Hondal RJ, Zhao Z, Riddle SR, Kravchuk AV, Liao H, Bruzik KS, Tsai MD. Phosphatidylinositol-specific phospholipase C. 3. Elucidation of the catalytic mechanism and comparison with ribonuclease A Journal of the American Chemical Society. 119: 9933-9934. DOI: 10.1021/ja9714402 |
1 |
|
| 1997 |
Hondal RJ, Bruzik KS, Zhao Z, Tsai MD. Mechanism of phosphatidylinositol-phospholipase C. 2. Reversal of a thio effect by site-directed mutagenesis [17] Journal of the American Chemical Society. 119: 5477-5478. DOI: 10.1021/ja964217y |
1 |
|
| 1997 |
Mihai C, Mataka J, Riddle S, Tsai MD, Bruzik KS. Synthesis of enantiomerically pure phosphorothiolate assay substrate for phosphatidylinositol-specific phospholipase C Bioorganic and Medicinal Chemistry Letters. 7: 1235-1238. DOI: 10.1016/S0960-894X(97)00197-2 |
1 |
|
| 1996 |
Xie W, Kaetzel MA, Bruzik KS, Dedman JR, Shears SB, Nelson DJ. Inositol 3,4,5,6-tetrakisphosphate inhibits the calmodulin-dependent protein kinase H-activated chloride conductance in T84 colonic epithelial cells Journal of Biological Chemistry. 271: 14092-14097. PMID 8662902 DOI: 10.1074/jbc.271.24.14092 |
1 |
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| 1994 |
Bruzik KS, Hakeem AA, Tsai MD. Are D- and L-chiro-phosphoinositides substrates of phosphatidylinositol-specific phospholipase C? Biochemistry. 33: 8367-8374. PMID 8031771 |
1 |
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| 1994 |
Bruzik KS, Tsai MD. Toward the mechanism of phosphoinositide-specific phospholipases C. Bioorganic & Medicinal Chemistry. 2: 49-72. PMID 7922124 |
1 |
|
| 1992 |
Bruzik KS, Morocho AM, Jhon DY, Rhee SG, Tsai MD. Phospholipids chiral at phosphorus. Stereochemical mechanism for the formation of inositol 1-phosphate catalyzed by phosphatidylinositol-specific phospholipase C. Biochemistry. 31: 5183-93. PMID 1318746 |
1 |
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| 1991 |
Bruzik KS, Tsai MD. Phospholipase stereospecificity at phosphorus. Methods in Enzymology. 197: 258-69. PMID 1646930 |
1 |
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| 1987 |
Bruzik KS, Tsai MD. A calorimetric study of the thermotropic behavior of pure sphingomyelin diastereomers. Biochemistry. 26: 5364-8. PMID 3676257 |
1 |
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| 1983 |
Bruzik K, Jiang RT, Tsai MD. Phospholipids chiral at phosphorus. Preparation and spectral properties of chiral thiophospholipids. Biochemistry. 22: 2478-86. PMID 6688028 DOI: 10.1021/bi00279a026 |
0.36 |
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