Sonia M. Najjar - Publications

1994- Medical College of Ohio, Toledo, OH, United States 
Pharmacology, Biochemistry

47 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Ghanem SS, Muturi HT, DeAngelis AM, Hu J, Kulkarni RN, Heinrich G, Najjar SM. Age-dependent insulin resistance in male mice with null deletion of the carcinoembryonic antigen-related cell adhesion molecule 2 gene. Diabetologia. PMID 28567513 DOI: 10.1007/s00125-017-4307-2  0.36
2017 Heinrich G, Muturi HT, Rezaei K, Al-Share QY, DeAngelis AM, Bowman TA, Ghadieh HE, Ghanem SS, Zhang D, Garofalo RS, Yin L, Najjar SM. Reduced Hepatic Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 Level in Obesity. Frontiers in Endocrinology. 8: 54. PMID 28396653 DOI: 10.3389/fendo.2017.00054  0.36
2017 Heinrich G, Ghadieh HE, Ghanem SS, Muturi HT, Rezaei K, Al-Share QY, Bowman TA, Zhang D, Garofalo RS, Yin L, Najjar SM. Loss of Hepatic CEACAM1: A Unifying Mechanism Linking Insulin Resistance to Obesity and Non-Alcoholic Fatty Liver Disease. Frontiers in Endocrinology. 8: 8. PMID 28184213 DOI: 10.3389/fendo.2017.00008  0.36
2016 Russo L, Ghadieh HE, Ghanem SS, Al-Share QY, Smiley ZN, Gatto-Weis C, Esakov EL, McInerney MF, Heinrich G, Tong X, Yin L, Najjar SM. Role for hepatic CEACAM1 in regulating fatty acid metabolism along the adipocyte-hepatocyte axis. Journal of Lipid Research. PMID 27777319 DOI: 10.1194/jlr.M072066  0.36
2016 Ramakrishnan SK, Khuder SS, Al-Share QY, Russo L, Abdallah SL, Patel PR, Heinrich G, Muturi HT, Mopidevi BR, Oyarce AM, Shah YM, Sanchez ER, Najjar SM. PPAR alpha Activation Reduces Hepatic CEACAM1 Expression to Regulate Fatty Acid Oxidation during Fasting-refeeding Transition. The Journal of Biological Chemistry. PMID 26846848 DOI: 10.1074/jbc.M116.714014  0.36
2015 Ghanem SS, Heinrich G, Lester SG, Pfeiffer V, Bhattacharya S, Patel PR, DeAngelis AM, Dai T, Ramakrishnan SK, Smiley ZN, Jung DY, Lee Y, Kitamura T, Ergun S, Kulkarni RN, ... ... Najjar SM, et al. Increased Glucose-induced Secretion of Glucagon-like Peptide-1 in Mice Lacking the Carcino-Embryonic Antigen-related Cell Adhesion Molecule 2. The Journal of Biological Chemistry. PMID 26586918 DOI: 10.1074/jbc.M115.692582  0.36
2015 Li C, Culver SA, Quadri S, Ledford KL, Al-Share QY, Ghadieh HE, Najjar SM, Siragy HM. High-fat diet amplifies renal renin angiotensin system expression, blood pressure elevation, and renal dysfunction caused by Ceacam1 null deletion. American Journal of Physiology. Endocrinology and Metabolism. 309: E802-10. PMID 26374765 DOI: 10.1152/ajpendo.00158.2015  0.36
2015 Lester SG, Russo L, Ghanem SS, Khuder SS, DeAngelis AM, Esakov EL, Bowman TA, Heinrich G, Al-Share QY, McInerney MF, Philbrick WM, Najjar SM. Hepatic CEACAM1 Over-Expression Protects Against Diet-Induced Fibrosis and Inflammation in White Adipose Tissue. Frontiers in Endocrinology. 6: 116. PMID 26284027 DOI: 10.3389/fendo.2015.00116  0.36
2015 Balasubramanian P, Varde PA, Abdallah SL, Najjar SM, MohanKumar PS, MohanKumar SM. Differential effects of prenatal stress on metabolic programming in diet-induced obese and dietary-resistant rats. American Journal of Physiology. Endocrinology and Metabolism. 309: E582-8. PMID 26219866 DOI: 10.1152/ajpendo.00167.2015  0.36
2015 Ghadieh HE, Smiley ZN, Kopfman MW, Najjar MG, Hake MJ, Najjar SM. Chlorogenic acid/chromium supplement rescues diet-induced insulin resistance and obesity in mice. Nutrition & Metabolism. 12: 19. PMID 26045713 DOI: 10.1186/s12986-015-0014-5  0.36
2015 Al-Share QY, DeAngelis AM, Lester SG, Bowman TA, Ramakrishnan SK, Abdallah SL, Russo L, Patel PR, Kaw MK, Raphael CK, Kim AJ, Heinrich G, Lee AD, Kim JK, Kulkarni RN, ... ... Najjar SM, et al. Forced Hepatic Overexpression of CEACAM1 Curtails Diet-Induced Insulin Resistance. Diabetes. 64: 2780-90. PMID 25972571 DOI: 10.2337/db14-1772  0.36
2015 Liu J, Ramakrishnan SK, Khuder SS, Kaw MK, Muturi HT, Lester SG, Lee SJ, Fedorova LV, Kim AJ, Mohamed IE, Gatto-Weis C, Eisenmann KM, Conran PB, Najjar SM. High-calorie diet exacerbates prostate neoplasia in mice with haploinsufficiency of Pten tumor suppressor gene. Molecular Metabolism. 4: 186-98. PMID 25737954 DOI: 10.1016/j.molmet.2014.12.011  0.36
2014 Alshahrani MM, Yang E, Yip J, Ghanem SS, Abdallah SL, deAngelis AM, O'Malley CJ, Moheimani F, Najjar SM, Jackson DE. CEACAM2 negatively regulates hemi (ITAM-bearing) GPVI and CLEC-2 pathways and thrombus growth in vitro and in vivo. Blood. 124: 2431-41. PMID 25085348 DOI: 10.1182/blood-2014-04-569707  0.36
2014 Stechschulte LA, Hinds TD, Ghanem SS, Shou W, Najjar SM, Sanchez ER. FKBP51 reciprocally regulates GRα and PPARγ activation via the Akt-p38 pathway. Molecular Endocrinology (Baltimore, Md.). 28: 1254-64. PMID 24933248 DOI: 10.1210/me.2014-1023  0.36
2014 Stechschulte LA, Hinds TD, Khuder SS, Shou W, Najjar SM, Sanchez ER. FKBP51 controls cellular adipogenesis through p38 kinase-mediated phosphorylation of GRα and PPARγ. Molecular Endocrinology (Baltimore, Md.). 28: 1265-75. PMID 24933247 DOI: 10.1210/me.2014-1022  0.36
2014 Pereira S, Park E, Mori Y, Haber CA, Han P, Uchida T, Stavar L, Oprescu AI, Koulajian K, Ivovic A, Yu Z, Li D, Bowman TA, Dewald J, El-Benna J, ... ... Najjar SM, et al. FFA-induced hepatic insulin resistance in vivo is mediated by PKCδ, NADPH oxidase, and oxidative stress. American Journal of Physiology. Endocrinology and Metabolism. 307: E34-46. PMID 24824652 DOI: 10.1152/ajpendo.00436.2013  0.36
2014 Kim JH, Meyers MS, Khuder SS, Abdallah SL, Muturi HT, Russo L, Tate CR, Hevener AL, Najjar SM, Leloup C, Mauvais-Jarvis F. Tissue-selective estrogen complexes with bazedoxifene prevent metabolic dysfunction in female mice. Molecular Metabolism. 3: 177-90. PMID 24634829 DOI: 10.1016/j.molmet.2013.12.009  0.36
2013 Najjar SM, Ledford KJ, Abdallah SL, Paus A, Russo L, Kaw MK, Ramakrishnan SK, Muturi HT, Raphael CK, Lester SG, Heinrich G, Pierre SV, Benndorf R, Kleff V, Jaffa AA, et al. Ceacam1 deletion causes vascular alterations in large vessels. American Journal of Physiology. Endocrinology and Metabolism. 305: E519-29. PMID 23800882 DOI: 10.1152/ajpendo.00266.2013  0.36
2012 Friedman TC, Sinha-Hikim I, Parveen M, Najjar SM, Liu Y, Mangubat M, Shin CS, Lyzlov A, Ivey R, Shaheen M, French SW, Sinha-Hikim AP. Additive effects of nicotine and high-fat diet on hepatic steatosis in male mice. Endocrinology. 153: 5809-20. PMID 23093702 DOI: 10.1210/en.2012-1750  0.36
2012 Chen XY, Gu XT, Saiyin H, Wan B, Zhang YJ, Li J, Wang YL, Gao R, Wang YF, Dong WP, Najjar SM, Zhang CY, Ding HF, Liu JO, Yu L. Brain-selective kinase 2 (BRSK2) phosphorylation on PCTAIRE1 negatively regulates glucose-stimulated insulin secretion in pancreatic β-cells. The Journal of Biological Chemistry. 287: 30368-75. PMID 22798068 DOI: 10.1074/jbc.M112.375618  0.36
2011 Hinds TD, Stechschulte LA, Cash HA, Whisler D, Banerjee A, Yong W, Khuder SS, Kaw MK, Shou W, Najjar SM, Sanchez ER. Protein phosphatase 5 mediates lipid metabolism through reciprocal control of glucocorticoid receptor and peroxisome proliferator-activated receptor-γ (PPARγ). The Journal of Biological Chemistry. 286: 42911-22. PMID 21994940 DOI: 10.1074/jbc.M111.311662  0.36
2011 Tiano JP, Delghingaro-Augusto V, Le May C, Liu S, Kaw MK, Khuder SS, Latour MG, Bhatt SA, Korach KS, Najjar SM, Prentki M, Mauvais-Jarvis F. Estrogen receptor activation reduces lipid synthesis in pancreatic islets and prevents β cell failure in rodent models of type 2 diabetes. The Journal of Clinical Investigation. 121: 3331-42. PMID 21747171 DOI: 10.1172/JCI44564  0.36
2011 Wuescher L, Angevine K, Hinds T, Ramakrishnan S, Najjar SM, Mensah-Osman EJ. Insulin regulates menin expression, cytoplasmic localization, and interaction with FOXO1. American Journal of Physiology. Endocrinology and Metabolism. 301: E474-83. PMID 21693693 DOI: 10.1152/ajpendo.00022.2011  0.36
2010 Bowman TA, Ramakrishnan SK, Kaw M, Lee SJ, Patel PR, Golla VK, Bourey RE, Haram PM, Koch LG, Britton SL, Wisløff U, Lee AD, Najjar SM. Caloric restriction reverses hepatic insulin resistance and steatosis in rats with low aerobic capacity. Endocrinology. 151: 5157-64. PMID 20861239 DOI: 10.1210/en.2010-0176  0.36
2010 Hinds TD, Ramakrishnan S, Cash HA, Stechschulte LA, Heinrich G, Najjar SM, Sanchez ER. Discovery of glucocorticoid receptor-beta in mice with a role in metabolism. Molecular Endocrinology (Baltimore, Md.). 24: 1715-27. PMID 20660300 DOI: 10.1210/me.2009-0411  0.36
2010 Warrier M, Hinds TD, Ledford KJ, Cash HA, Patel PR, Bowman TA, Stechschulte LA, Yong W, Shou W, Najjar SM, Sanchez ER. Susceptibility to diet-induced hepatic steatosis and glucocorticoid resistance in FK506-binding protein 52-deficient mice. Endocrinology. 151: 3225-36. PMID 20427484 DOI: 10.1210/en.2009-1158  0.36
2010 Heinrich G, Ghosh S, Deangelis AM, Schroeder-Gloeckler JM, Patel PR, Castaneda TR, Jeffers S, Lee AD, Jung DY, Zhang Z, Opland DM, Myers MG, Kim JK, Najjar SM. Carcinoembryonic antigen-related cell adhesion molecule 2 controls energy balance and peripheral insulin action in mice. Gastroenterology. 139: 644-52, 652.e1. PMID 20381490 DOI: 10.1053/j.gastro.2010.03.056  0.36
2009 Gayen JR, Saberi M, Schenk S, Biswas N, Vaingankar SM, Cheung WW, Najjar SM, O'Connor DT, Bandyopadhyay G, Mahata SK. A novel pathway of insulin sensitivity in chromogranin A null mice: a crucial role for pancreastatin in glucose homeostasis. The Journal of Biological Chemistry. 284: 28498-509. PMID 19706599 DOI: 10.1074/jbc.M109.020636  0.36
2009 Haram PM, Kemi OJ, Lee SJ, Bendheim MØ, Al-Share QY, Waldum HL, Gilligan LJ, Koch LG, Britton SL, Najjar SM, Wisløff U. Aerobic interval training vs. continuous moderate exercise in the metabolic syndrome of rats artificially selected for low aerobic capacity. Cardiovascular Research. 81: 723-32. PMID 19047339 DOI: 10.1093/cvr/cvn332  0.36
2008 Lee SJ, Heinrich G, Fedorova L, Al-Share QY, Ledford KJ, Fernstrom MA, McInerney MF, Erickson SK, Gatto-Weis C, Najjar SM. Development of nonalcoholic steatohepatitis in insulin-resistant liver-specific S503A carcinoembryonic antigen-related cell adhesion molecule 1 mutant mice. Gastroenterology. 135: 2084-95. PMID 18848945 DOI: 10.1053/j.gastro.2008.08.007  0.36
2008 Tjønna AE, Lee SJ, Rognmo Ø, Stølen TO, Bye A, Haram PM, Loennechen JP, Al-Share QY, Skogvoll E, Slørdahl SA, Kemi OJ, Najjar SM, Wisløff U. Aerobic interval training versus continuous moderate exercise as a treatment for the metabolic syndrome: a pilot study. Circulation. 118: 346-54. PMID 18606913 DOI: 10.1161/CIRCULATIONAHA.108.772822  0.36
2008 DeAngelis AM, Heinrich G, Dai T, Bowman TA, Patel PR, Lee SJ, Hong EG, Jung DY, Assmann A, Kulkarni RN, Kim JK, Najjar SM. Carcinoembryonic antigen-related cell adhesion molecule 1: a link between insulin and lipid metabolism. Diabetes. 57: 2296-303. PMID 18544705 DOI: 10.2337/db08-0379  0.36
2008 Bye A, Sørhaug S, Ceci M, Høydal MA, Stølen T, Heinrich G, Tjønna AE, Najjar SM, Nilsen OG, Catalucci D, Grimaldi S, Contu R, Steinshamn S, Condorelli G, Smith GL, et al. Carbon monoxide levels experienced by heavy smokers impair aerobic capacity and cardiac contractility and induce pathological hypertrophy. Inhalation Toxicology. 20: 635-46. PMID 18464052 DOI: 10.1080/08958370701883821  0.36
2006 Nagaishi T, Pao L, Lin SH, Iijima H, Kaser A, Qiao SW, Chen Z, Glickman J, Najjar SM, Nakajima A, Neel BG, Blumberg RS. SHP1 Phosphatase-Dependent T Cell Inhibition by CEACAM1 Adhesion Molecule Isoforms Immunity. 25: 769-781. PMID 17081782 DOI: 10.1016/j.immuni.2006.08.026  0.36
2005 Najjar SM, Yang Y, Fernström MA, Lee SJ, Deangelis AM, Rjaily GA, Al-Share QY, Dai T, Miller TA, Ratnam S, Ruch RJ, Smith S, Lin SH, Beauchemin N, Oyarce AM. Insulin acutely decreases hepatic fatty acid synthase activity. Cell Metabolism. 2: 43-53. PMID 16054098 DOI: 10.1016/j.cmet.2005.06.001  0.36
2004 McInerney MF, Najjar SM, Brickley D, Lutzke M, Abou-Rjaily GA, Reifsnyder P, Haskell BD, Flurkey K, Zhang YJ, Pietropaolo SL, Pietropaolo M, Byers JP, Leiter EH. Anti-insulin receptor autoantibodies are not required for type 2 diabetes pathogenesis in NZL/Lt mice, a New Zealand obese (NZO)-derived mouse strain. Experimental Diabesity Research. 5: 177-85. PMID 15512785 DOI: 10.1080/15438600490478029  0.36
2004 Abou-Rjaily GA, Lee SJ, May D, Al-Share QY, Deangelis AM, Ruch RJ, Neumaier M, Kalthoff H, Lin SH, Najjar SM. CEACAM1 modulates epidermal growth factor receptor--mediated cell proliferation. The Journal of Clinical Investigation. 114: 944-52. PMID 15467833 DOI: 10.1172/JCI21786  0.36
2004 Dai T, Abou-Rjaily GA, Al-Share' QY, Yang Y, Fernström MA, Deangelis AM, Lee AD, Sweetman L, Amato A, Pasquali M, Lopaschuk GD, Erickson SK, Najjar SM. Interaction between altered insulin and lipid metabolism in CEACAM1-inactive transgenic mice. The Journal of Biological Chemistry. 279: 45155-61. PMID 15316023 DOI: 10.1074/jbc.M404764200  0.36
2004 Phan D, Cheng CJ, Galfione M, Vakar-Lopez F, Tunstead J, Thompson NE, Burgess RR, Najjar SM, Yu-Lee LY, Lin SH. Identification of Sp2 as a transcriptional repressor of carcinoembryonic antigen-related cell adhesion molecule 1 in tumorigenesis. Cancer Research. 64: 3072-8. PMID 15126343 DOI: 10.1158/0008-5472.CAN-03-3730  0.36
2002 Northcott CA, Poy MN, Najjar SM, Watts SW. Phosphoinositide 3-kinase mediates enhanced spontaneous and agonist-induced contraction in aorta of deoxycorticosterone acetate-salt hypertensive rats. Circulation Research. 91: 360-9. PMID 12193470 DOI: 10.1161/01.RES.0000030861.13850.F1  0.36
2002 Poy MN, Yang Y, Rezaei K, Fernström MA, Lee AD, Kido Y, Erickson SK, Najjar SM. CEACAM1 regulates insulin clearance in liver. Nature Genetics. 30: 270-6. PMID 11850617 DOI: 10.1038/ng840  0.36
2002 Poy MN, Ruch RJ, Fernstrom MA, Okabayashi Y, Najjar SM. Shc and CEACAM1 interact to regulate the mitogenic action of insulin. The Journal of Biological Chemistry. 277: 1076-84. PMID 11694516 DOI: 10.1074/jbc.M108415200  0.36
2001 Han E, Phan D, Lo P, Poy MN, Behringer R, Najjar SM, Lin SH. Differences in tissue-specific and embryonic expression of mouse Ceacam1 and Ceacam2 genes. The Biochemical Journal. 355: 417-23. PMID 11284729  0.36
2000 Soni P, Lakkis M, Poy MN, Fernström MA, Najjar SM. The differential effects of pp120 (Ceacam 1) on the mitogenic action of insulin and insulin-like growth factor 1 are regulated by the nonconserved tyrosine 1316 in the insulin receptor. Molecular and Cellular Biology. 20: 3896-905. PMID 10805733  0.36
1999 Choice CV, Poy MN, Formisano P, Najjar SM. Comparison of the intracellular trafficking of two alternatively spliced isoforms of pp120, a substrate of the insulin receptor tyrosine kinase. Journal of Cellular Biochemistry. 76: 133-42. PMID 10581007 DOI: 10.1002/(SICI)1097-4644(20000101)76:1<133::AID-JCB13>3.0.CO;2-B  0.36
1998 Choice CV, Howard MJ, Poy MN, Hankin MH, Najjar SM. Insulin stimulates pp120 endocytosis in cells co-expressing insulin receptors. The Journal of Biological Chemistry. 273: 22194-200. PMID 9712832 DOI: 10.1074/jbc.273.35.22194  0.36
1998 Najjar SM, Choice CV, Soni P, Whitman CM, Poy MN. Effect of pp120 on receptor-mediated insulin endocytosis is regulated by the juxtamembrane domain of the insulin receptor. The Journal of Biological Chemistry. 273: 12923-8. PMID 9582324 DOI: 10.1074/jbc.273.21.12923  0.36
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