| Year |
Citation |
Score |
| 2022 |
Marei I, Ahmetaj-Shala B, Triggle CR. Biofunctionalization of cardiovascular stents to induce endothelialization: Implications for in- stent thrombosis in diabetes. Frontiers in Pharmacology. 13: 982185. PMID 36299902 DOI: 10.3389/fphar.2022.982185 |
0.312 |
|
| 2022 |
Triggle CR, Marei I, Ye K, Ding H, Anderson TJ, Hollenberg MD, Hill MA. Repurposing Metformin for Vascular Disease. Current Medicinal Chemistry. PMID 35909294 DOI: 10.2174/0929867329666220729154615 |
0.516 |
|
| 2022 |
Triggle CR, Mohammed I, Bshesh K, Marei I, Ye K, Ding H, MacDonald R, Hollenberg MD, Hill MA. Metformin: Is it a drug for all reasons and diseases? Metabolism: Clinical and Experimental. 155223. PMID 35640743 DOI: 10.1016/j.metabol.2022.155223 |
0.468 |
|
| 2022 |
Marei I, Abu Samaan T, Al-Quradaghi MA, Farah AA, Mahmud SH, Ding H, Triggle CR. 3D Tissue-Engineered Vascular Drug Screening Platforms: Promise and Considerations. Frontiers in Cardiovascular Medicine. 9: 847554. PMID 35310996 DOI: 10.3389/fcvm.2022.847554 |
0.405 |
|
| 2021 |
Pulakazhi Venu VK, Saifeddine M, Mihara K, Faiza M, Gorobets E, Flewelling AJ, Derksen D, Hirota S, Marei I, Al-Majid D, Motahhary M, Ding H, Triggle CR, Hollenberg MD. Molecular Pharmacology. PMID 34452975 DOI: 10.1124/molpharm.120.000148 |
0.553 |
|
| 2021 |
Mohammed I, Hollenberg MD, Ding H, Triggle CR. A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan. Frontiers in Endocrinology. 12: 718942. PMID 34421827 DOI: 10.3389/fendo.2021.718942 |
0.466 |
|
| 2021 |
Triggle CR, Bansal D, Ding H, Islam MM, Farag EABA, Hadi HA, Sultan AA. A Comprehensive Review of Viral Characteristics, Transmission, Pathophysiology, Immune Response, and Management of SARS-CoV-2 and COVID-19 as a Basis for Controlling the Pandemic. Frontiers in Immunology. 12: 631139. PMID 33717166 DOI: 10.3389/fimmu.2021.631139 |
0.353 |
|
| 2020 |
Sharma O, Sultan AA, Ding H, Triggle CR. A Review of the Progress and Challenges of Developing a Vaccine for COVID-19. Frontiers in Immunology. 11: 585354. PMID 33163000 DOI: 10.3389/fimmu.2020.585354 |
0.308 |
|
| 2020 |
Triggle CR, Bansal D, Farag EABA, Ding H, Sultan AA. COVID-19: Learning from Lessons To Guide Treatment and Prevention Interventions. Msphere. 5. PMID 32404514 DOI: 10.1128/mSphere.00317-20 |
0.354 |
|
| 2020 |
Triggle CR, Ding H, Marei I, Anderson TJ, Hollenberg MD. Why the endothelium? The endothelium as a target to reduce diabetes-associated vascular disease.' Canadian Journal of Physiology and Pharmacology. PMID 32150686 DOI: 10.1139/Cjpp-2019-0677 |
0.548 |
|
| 2019 |
Mathews Samuel S, Satheesh NJ, Ghosh S, Büsselberg D, Majeed Y, Ding H, Triggle CR. Treatment with a Combination of Metformin and 2-Deoxyglucose Upregulates Thrombospondin-1 in Microvascular Endothelial Cells: Implications in Anti-Angiogenic Cancer Therapy. Cancers. 11. PMID 31698699 DOI: 10.3390/Cancers11111737 |
0.46 |
|
| 2019 |
Majeed Y, Upadhyay R, Alhousseiny S, Taha T, Musthak A, Shaheen Y, Jameel M, Triggle CR, Ding H. Potent and PPARα-independent anti-proliferative action of the hypolipidemic drug fenofibrate in VEGF-dependent angiosarcomas in vitro. Scientific Reports. 9: 6316. PMID 31004117 DOI: 10.1038/S41598-019-42838-Y |
0.452 |
|
| 2019 |
Pulakazhi Venu VK, El-Daly M, Saifeddine M, Hirota SA, Ding H, Triggle CR, Hollenberg MD. Minimizing Hyperglycemia-Induced Vascular Endothelial Dysfunction by Inhibiting Endothelial Sodium-Glucose Cotransporter 2 and Attenuating Oxidative Stress: Implications for Treating Individuals With Type 2 Diabetes. Canadian Journal of Diabetes. PMID 30930073 DOI: 10.1016/J.Jcjd.2019.01.005 |
0.583 |
|
| 2019 |
Geng L, Liao B, Jin L, Huang Z, Triggle CR, Ding H, Zhang J, Huang Y, Lin Z, Xu A. Exercise Alleviates Obesity-Induced Metabolic Dysfunction via Enhancing FGF21 Sensitivity in Adipose Tissues. Cell Reports. 26: 2738-2752.e4. PMID 30840894 DOI: 10.1016/J.Celrep.2019.02.014 |
0.36 |
|
| 2018 |
Ding H, Ye K, Triggle CR. Impact of currently used anti-diabetic drugs on myoendothelial communication. Current Opinion in Pharmacology. 45: 1-7. PMID 30502742 DOI: 10.1016/J.Coph.2018.11.002 |
0.58 |
|
| 2018 |
El-Daly M, Venu VKP, Saifeddine M, Mihara K, Kang S, Fedak PWM, Alston LA, Hirota SA, Ding H, Triggle CR, Hollenberg MD. Hyperglycaemic impairment of PAR2-mediated vasodilation: Prevention by inhibition of aortic endothelial sodium-glucose-co-Transporter-2 and minimizing oxidative stress. Vascular Pharmacology. PMID 29908295 DOI: 10.1016/J.Vph.2018.06.006 |
0.556 |
|
| 2018 |
Lemmey HAL, Ye X, Ding H, Triggle CR, Garland CJ, Dora KA. Hyperglycaemia disrupts conducted vasodilation in the resistance vasculature of db/db mice. Vascular Pharmacology. PMID 29339138 DOI: 10.1016/J.Vph.2018.01.002 |
0.505 |
|
| 2017 |
Samuel SM, Ghosh S, Majeed Y, Arunachalam G, Emara MM, Ding H, Triggle CR. Metformin Represses Glucose Starvation Induced Autophagic Response in Microvascular Endothelial Cells and Promotes Cell Death. Biochemical Pharmacology. PMID 28274614 DOI: 10.1016/J.Bcp.2017.03.001 |
0.436 |
|
| 2017 |
Triggle C, Samuel S, Ding H. Metformin: Anti-angiogenic Effects In 2-Deoxyglucose Treated Microvascular Endothelial Cells Via Enhancement Of Thrombospondin-1 Canadian Journal of Diabetes. 41: S82. DOI: 10.1016/J.Jcjd.2017.08.237 |
0.543 |
|
| 2016 |
Triggle C, Arunachalam G, Lakshmanan A, Samuel S, Ghosh S, Ding H. Anti-Ageing Effects of Metformin on the Vascular Endothelium Canadian Journal of Diabetes. 40: S70-S71. DOI: 10.1016/J.Jcjd.2016.08.203 |
0.52 |
|
| 2015 |
Triggle CR, Ding H. Metformin is not just an antihyperglycaemic drug but also has protective effects on the vascular endothelium. Acta Physiologica (Oxford, England). PMID 26680745 DOI: 10.1111/Apha.12644 |
0.592 |
|
| 2015 |
Arunachalam G, Lakshmanan AP, Samuel SM, Triggle C, Ding H. Molecular interplay between microRNA-34a and sirtuin1 in hyperglycaemia-mediated impaired angiogenesis in endothelial cells: Effects of metformin. The Journal of Pharmacology and Experimental Therapeutics. PMID 26582729 DOI: 10.1124/Jpet.115.226894 |
0.415 |
|
| 2015 |
Ghosh S, Lakshmanan AP, Hwang MJ, Kubba H, Mushannen A, Triggle CR, Ding H. Metformin improves endothelial function in aortic tissue and microvascular endothelial cells subjected to diabetic hyperglycaemic conditions. Biochemical Pharmacology. PMID 26467186 DOI: 10.1016/J.Bcp.2015.10.008 |
0.585 |
|
| 2015 |
Kinaan M, Ding H, Triggle CR. Metformin: An Old Drug for the Treatment of Diabetes but a New Drug for the Protection of the Endothelium. Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre. 24: 401-15. PMID 26021280 DOI: 10.1159/000381643 |
0.503 |
|
| 2015 |
Lin Z, Pan X, Wu F, Ye D, Zhang Y, Wang Y, Jin L, Lian Q, Huang Y, Ding H, Triggle C, Wang K, Li X, Xu A. Fibroblast growth factor 21 prevents atherosclerosis by suppression of hepatic sterol regulatory element-binding protein-2 and induction of adiponectin in mice. Circulation. 131: 1861-71. PMID 25794851 DOI: 10.1161/Circulationaha.115.015308 |
0.481 |
|
| 2015 |
Arunachalam G, Upadhyay R, Ding H, Triggle CR. MicroRNA Signature and Cardiovascular Dysfunction. Journal of Cardiovascular Pharmacology. 65: 419-29. PMID 25384197 DOI: 10.1097/Fjc.0000000000000178 |
0.372 |
|
| 2014 |
Triggle CR, Ding H. Cardiovascular impact of drugs used in the treatment of diabetes. Therapeutic Advances in Chronic Disease. 5: 245-68. PMID 25364492 DOI: 10.1177/2040622314546125 |
0.441 |
|
| 2014 |
Liang Q, Zhong L, Zhang J, Wang Y, Bornstein SR, Triggle CR, Ding H, Lam KS, Xu A. FGF21 maintains glucose homeostasis by mediating the cross talk between liver and brain during prolonged fasting. Diabetes. 63: 4064-75. PMID 25024372 DOI: 10.2337/Db14-0541 |
0.366 |
|
| 2014 |
Arunachalam G, Samuel SM, Marei I, Ding H, Triggle CR. Metformin modulates hyperglycaemia-induced endothelial senescence and apoptosis through SIRT1. British Journal of Pharmacology. 171: 523-35. PMID 24372553 DOI: 10.1111/Bph.12496 |
0.602 |
|
| 2012 |
Triggle CR, Samuel SM, Ravishankar S, Marei I, Arunachalam G, Ding H. The endothelium: influencing vascular smooth muscle in many ways. Canadian Journal of Physiology and Pharmacology. 90: 713-38. PMID 22625870 DOI: 10.1139/Y2012-073 |
0.582 |
|
| 2012 |
Basha B, Samuel SM, Triggle CR, Ding H. Endothelial dysfunction in diabetes mellitus: possible involvement of endoplasmic reticulum stress? Experimental Diabetes Research. 2012: 481840. PMID 22474423 DOI: 10.1155/2012/481840 |
0.527 |
|
| 2012 |
Chen X, Li Y, Hollenberg M, Triggle CR, Ding H. The contribution of d-tubocurarine-sensitive and apamin-sensitive K-channels to EDHF-mediated relaxation of mesenteric arteries from eNOS-/- mice. Journal of Cardiovascular Pharmacology. 59: 413-25. PMID 22217882 DOI: 10.1097/Fjc.0B013E318248Acd9 |
0.475 |
|
| 2011 |
Li Y, Mihara K, Saifeddine M, Krawetz A, Lau DC, Li H, Ding H, Triggle CR, Hollenberg MD. Perivascular adipose tissue-derived relaxing factors: release by peptide agonists via proteinase-activated receptor-2 (PAR2) and non-PAR2 mechanisms. British Journal of Pharmacology. 164: 1990-2002. PMID 21615723 DOI: 10.1111/J.1476-5381.2011.01501.X |
0.442 |
|
| 2011 |
Triggle CR, Ding H. The endothelium in compliance and resistance vessels. Frontiers in Bioscience (Scholar Edition). 3: 730-44. PMID 21196408 DOI: 10.2741/S183 |
0.564 |
|
| 2010 |
Triggle CR, Ding H. A review of endothelial dysfunction in diabetes: a focus on the contribution of a dysfunctional eNOS. Journal of the American Society of Hypertension : Jash. 4: 102-15. PMID 20470995 DOI: 10.1016/J.Jash.2010.02.004 |
0.54 |
|
| 2010 |
Ding H, Triggle CR. Endothelial dysfunction in diabetes: multiple targets for treatment. PflüGers Archiv : European Journal of Physiology. 459: 977-94. PMID 20238124 DOI: 10.1007/S00424-010-0807-3 |
0.569 |
|
| 2009 |
Potocnik SJ, McSherry I, Ding H, Murphy TV, Kotecha N, Dora KA, Yuill KH, Triggle CR, Hill MA. Endothelium-dependent vasodilation in myogenically active mouse skeletal muscle arterioles: role of EDH and K(+) channels. Microcirculation (New York, N.Y. : 1994). 16: 377-90; 1 p followin. PMID 19424929 DOI: 10.1080/10739680902804042 |
0.433 |
|
| 2008 |
Ellis A, Cheng ZJ, Li Y, Jiang YF, Yang J, Pannirselvam M, Ding H, Hollenberg MD, Triggle CR. Effects of a Western diet versus high glucose on endothelium-dependent relaxation in murine micro- and macro-vasculature. European Journal of Pharmacology. 601: 111-7. PMID 18996368 DOI: 10.1016/J.Ejphar.2008.10.042 |
0.456 |
|
| 2008 |
Triggle CR. Defying the economists: a decrease in heart rate improves not only cardiac but also endothelial function. British Journal of Pharmacology. 154: 727-8. PMID 18438420 DOI: 10.1038/Bjp.2008.168 |
0.326 |
|
| 2007 |
Cheng ZJ, Jiang YF, Ding H, Severson D, Triggle CR. Vascular dysfunction in type 2 diabetic TallyHo mice: role for an increase in the contribution of PGH2/TxA2 receptor activation and cytochrome p450 products. Canadian Journal of Physiology and Pharmacology. 85: 404-12. PMID 17612649 DOI: 10.1139/y07-010 |
0.487 |
|
| 2007 |
Ding H, Aljofan M, Triggle CR. Oxidative stress and increased eNOS and NADPH oxidase expression in mouse microvessel endothelial cells. Journal of Cellular Physiology. 212: 682-9. PMID 17443690 DOI: 10.1002/Jcp.21063 |
0.466 |
|
| 2007 |
Ceroni L, Ellis A, Wiehler WB, Jiang YF, Ding H, Triggle CR. Calcium-activated potassium channel and connexin expression in small mesenteric arteries from eNOS-deficient (eNOS-/-) and eNOS-expressing (eNOS+/+) mice. European Journal of Pharmacology. 560: 193-200. PMID 17300779 DOI: 10.1016/J.Ejphar.2007.01.018 |
0.466 |
|
| 2007 |
Ng ES, Cheng ZJ, Ellis A, Ding H, Jiang Y, Li Y, Hollenberg MD, Triggle CR. Nitrosothiol stores in vascular tissue: modulation by ultraviolet light, acetylcholine and ionomycin. European Journal of Pharmacology. 560: 183-92. PMID 17292350 DOI: 10.1016/J.Ejphar.2007.01.016 |
0.501 |
|
| 2007 |
Ding H, Hashem M, Triggle C. Increased oxidative stress in the streptozotocin-induced diabetic apoE-deficient mouse: changes in expression of NADPH oxidase subunits and eNOS. European Journal of Pharmacology. 561: 121-8. PMID 17292348 DOI: 10.1016/J.Ejphar.2006.12.034 |
0.58 |
|
| 2007 |
Wilson AM, Swan JD, Ding H, Zhang Y, Whitbourn RJ, Gurry J, Yii M, Wilson AC, Hill M, Triggle C, Best JD, Jenkins AJ. Widespread vascular production of C-reactive protein (CRP) and a relationship between serum CRP, plaque CRP and intimal hypertrophy. Atherosclerosis. 191: 175-81. PMID 16765355 DOI: 10.1016/J.Atherosclerosis.2006.03.034 |
0.503 |
|
| 2006 |
Pannirselvam M, Ding H, Anderson TJ, Triggle CR. Pharmacological characteristics of endothelium-derived hyperpolarizing factor-mediated relaxation of small mesenteric arteries from db/db mice. European Journal of Pharmacology. 551: 98-107. PMID 17027963 DOI: 10.1016/J.Ejphar.2006.08.086 |
0.498 |
|
| 2005 |
Ding H, Triggle CR. Endothelial cell dysfunction and the vascular complications associated with type 2 diabetes: assessing the health of the endothelium. Vascular Health and Risk Management. 1: 55-71. PMID 17319098 DOI: 10.2147/Vhrm.1.1.55.58939 |
0.526 |
|
| 2005 |
Triggle CR, Howarth A, Cheng ZJ, Ding H. Twenty-five years since the discovery of endothelium-derived relaxing factor (EDRF): does a dysfunctional endothelium contribute to the development of type 2 diabetes? Canadian Journal of Physiology and Pharmacology. 83: 681-700. PMID 16333371 DOI: 10.1139/Y05-069 |
0.516 |
|
| 2005 |
Ding H, Hashem M, Wiehler WB, Lau W, Martin J, Reid J, Triggle C. Endothelial dysfunction in the streptozotocin-induced diabetic apoE-deficient mouse. British Journal of Pharmacology. 146: 1110-8. PMID 16231005 DOI: 10.1038/Sj.Bjp.0706417 |
0.591 |
|
| 2005 |
Ding H, Howarth AG, Pannirselvam M, Anderson TJ, Severson DL, Wiehler WB, Triggle CR, Tuana BS. Endothelial dysfunction in Type 2 diabetes correlates with deregulated expression of the tail-anchored membrane protein SLMAP. American Journal of Physiology. Heart and Circulatory Physiology. 289: H206-11. PMID 15764684 DOI: 10.1152/Ajpheart.00037.2005 |
0.587 |
|
| 2005 |
Andrews KL, Pannirselvam M, Anderson TJ, Jenkins AJ, Triggle CR, Hill MA. The vascular endothelium in diabetes: a practical target for drug treatment? Expert Opinion On Therapeutic Targets. 9: 101-17. PMID 15757485 DOI: 10.1517/14728222.9.1.101 |
0.454 |
|
| 2004 |
Triggle CR, Ding H, Anderson TJ, Pannirselvam M. The endothelium in health and disease: A discussion of the contribution of non-nitric oxide endothelium-derived vasoactive mediators to vascular homeostasis in normal vessels and in type II diabetes. Molecular and Cellular Biochemistry. 263: 21-7. PMID 27520662 DOI: 10.1023/B:Mcbi.0000041845.62061.C9 |
0.602 |
|
| 2004 |
McGuire JJ, Hollenberg MD, Bennett BM, Triggle CR. Hyperpolarization of murine small caliber mesenteric arteries by activation of endothelial proteinase-activated receptor 2. Canadian Journal of Physiology and Pharmacology. 82: 1103-12. PMID 15644953 DOI: 10.1139/Y04-121 |
0.305 |
|
| 2004 |
Triggle CR, Ding H, Anderson TJ, Pannirselvam M. The endothelium in health and disease: a discussion of the contribution of non-nitric oxide endothelium-derived vasoactive mediators to vascular homeostasis in normal vessels and in type II diabetes. Molecular and Cellular Biochemistry. 263: 21-7. PMID 15524164 |
0.552 |
|
| 2003 |
Triggle CR, Hollenberg M, Anderson TJ, Ding H, Jiang Y, Ceroni L, Wiehler WB, Ng ES, Ellis A, Andrews K, McGuire JJ, Pannirselvam M. The endothelium in health and disease--a target for therapeutic intervention. Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi. 39: 249-67. PMID 15048017 DOI: 10.1540/Jsmr.39.249 |
0.572 |
|
| 2003 |
Ellis A, Triggle CR. Endothelium-derived reactive oxygen species: their relationship to endothelium-dependent hyperpolarization and vascular tone. Canadian Journal of Physiology and Pharmacology. 81: 1013-28. PMID 14719036 DOI: 10.1139/y03-106 |
0.347 |
|
| 2003 |
Andrews KL, McGuire JJ, Triggle CR. A photosensitive vascular smooth muscle store of nitric oxide in mouse aorta: no dependence on expression of endothelial nitric oxide synthase. British Journal of Pharmacology. 138: 932-40. PMID 12642395 DOI: 10.1038/sj.bjp.0705115 |
0.322 |
|
| 2003 |
Ding H, Triggle CR. Contribution of EDHF and the role of potassium channels in the regulation of vascular tone Drug Development Research. 58: 81-89. DOI: 10.1002/Ddr.10135 |
0.505 |
|
| 2003 |
Pannirselvam M, Anderson TJ, Triggle CR. Endothelial cell dysfunction in type I and II diabetes: The cellular basis for dysfunction Drug Development Research. 58: 28-41. DOI: 10.1002/ddr.10127 |
0.311 |
|
| 2002 |
Andrews KL, Triggle CR, Ellis A. NO and the vasculature: where does it come from and what does it do? Heart Failure Reviews. 7: 423-45. PMID 12379826 DOI: 10.1023/A:1020702215520 |
0.333 |
|
| 2002 |
Triggle CR, Ding H. Endothelium-derived hyperpolarizing factor: is there a novel chemical mediator? Clinical and Experimental Pharmacology & Physiology. 29: 153-60. PMID 11906476 DOI: 10.1046/J.1440-1681.2002.03632.X |
0.565 |
|
| 2001 |
Ding H, Triggle CR. Novel endothelium-derived relaxing factors. Identification of factors and cellular targets. Journal of Pharmacological and Toxicological Methods. 44: 441-52. PMID 11325586 DOI: 10.1016/S1056-8719(00)00127-1 |
0.542 |
|
| 2001 |
Lovren F, Triggle C. Nitric oxide and sodium nitroprusside-induced relaxation of the human umbilical artery. British Journal of Pharmacology. 131: 521-9. PMID 11015303 DOI: 10.1038/Sj.Bjp.0703588 |
0.33 |
|
| 2001 |
Pannirselvam M, Anderson T, Triggle C. Bradykinin-induced endothelium-dependent relaxation of mesenteric arterioles in diabetic (DB/DB -/-) mice is mediated by endothelium-derived hyperpolarizing factor Journal of Molecular and Cellular Cardiology. 33: A174. DOI: 10.1016/S0022-2828(01)90669-8 |
0.321 |
|
| 2001 |
Ding H, Triggle C. Endothelium-dependent hyperpolarization of mesenteric resistance arterioles from endothelial nitric oxide synthase “knockout” mice (Enos-/-) Journal of Molecular and Cellular Cardiology. 33: A165. DOI: 10.1016/S0022-2828(01)90631-5 |
0.302 |
|
| 2000 |
Ding H, Kubes P, Triggle C. Potassium- and acetylcholine-induced vasorelaxation in mice lacking endothelial nitric oxide synthase. British Journal of Pharmacology. 129: 1194-200. PMID 10725268 DOI: 10.1038/Sj.Bjp.0703144 |
0.525 |
|
| 1999 |
Waldron GJ, Ding H, Lovren F, Kubes P, Triggle CR. Acetylcholine-induced relaxation of peripheral arteries isolated from mice lacking endothelial nitric oxide synthase. British Journal of Pharmacology. 128: 653-8. PMID 10516645 DOI: 10.1038/Sj.Bjp.0702858 |
0.47 |
|
| 1995 |
Triggle C, Bevan J. Introduction to Symposium Reviews of the VIIIth International Symposium on Vascular Neuroeffeetor Mechanisms Canadian Journal of Physiology and Pharmacology. 73: 519-520. DOI: 10.1139/Y95-066 |
0.302 |
|
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