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Sheng-Xiang Lin - Publications

Affiliations: 
Universite Laval (Canada) 
Area:
Animal Physiology Biology, Biochemistry
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53 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Zhang WF, Li T, Lin SX. Meta-Analysis of steroid-converting enzymes and related receptors in prostate cancer suggesting novel combined therapies. The Journal of Steroid Biochemistry and Molecular Biology. 105559. PMID 31783154 DOI: 10.1016/j.jsbmb.2019.105559  0.36
2019 Liu WJ, Zhao G, Zhang CY, Yang CQ, Zeng XB, Li J, Zhu K, Zhao SQ, Lu HM, Yin DC, Lin SX. Comparison of the roles of estrogens and androgens in breast cancer and prostate cancer. Journal of Cellular Biochemistry. PMID 31693255 DOI: 10.1002/jcb.29515  0.48
2019 Zhang CY, Calvo EL, Yang CQ, Liu J, Sang XY, Lin SX. Transcriptome of 17β-hydroxysteroid dehydrogenase type 2 plays both hormone-dependent and hormone-independent roles in MCF-7 breast cancer cells. The Journal of Steroid Biochemistry and Molecular Biology. 105471. PMID 31513846 DOI: 10.1016/j.jsbmb.2019.105471  0.48
2019 Tchernof A, Lin SX, Luu-The V, Simard J. The Passing of Dr. Fernand Labrie (1937-2019): The legacy of excellence in science. The Journal of Steroid Biochemistry and Molecular Biology. PMID 30779933 DOI: 10.1016/j.jsbmb.2019.02.005  0.32
2019 Li T, Stephen P, Zhu DW, Shi R, Lin SX. Crystal structures of human 17β-hydroxysteroid dehydrogenase type 1 complexed with estrone and NADP reveal the mechanism of substrate inhibition. The Febs Journal. PMID 30768851 DOI: 10.1111/febs.14784  0.52
2019 Ran Q, Xiang Y, Stephen P, Wu C, Li T, Lin SX, Li Z. CRIF1-CDK2 Interface Inhibitors: An Unprecedented Strategy for Modulation of Cell Radiosensitivity. Journal of the American Chemical Society. PMID 30653304 DOI: 10.1021/jacs.8b10207  0.36
2019 Li T, Zhang W, Hao J, Sun M, Lin SX. Cold-active extracellular lipase: Expression in Sf9 insect cells, purification, and catalysis. Biotechnology Reports (Amsterdam, Netherlands). 21: e00295. PMID 30568889 DOI: 10.1016/j.btre.2018.e00295  0.36
2018 Li T, Maltais R, Poirier D, Lin SX. Combined Biophysical Chemistry Reveals the Finding of a New Covalent Inhibitor with a Low-Reactive Alkyl Halide. The Journal of Physical Chemistry Letters. PMID 30148957 DOI: 10.1021/acs.jpclett.8b02225  0.36
2018 Hsiao YF, Tsai PJ, Chen HS, Lin SX, Hung CC, Lee CH, Chen YH, Chen YF, Yu IA, Chen YC. Highly Efficient Coherent Optical Memory Based on Electromagnetically Induced Transparency. Physical Review Letters. 120: 183602. PMID 29775362 DOI: 10.1103/PhysRevLett.120.183602  0.72
2018 Stephen P, Ye S, Zhou M, Song J, Zhang R, Wang ED, Giegé R, Lin SX. Structure of Escherichia coli arginyl-tRNA synthetase in complex with tRNA: pivotal role of the D-loop. Journal of Molecular Biology. PMID 29678554 DOI: 10.1016/j.jmb.2018.04.011  0.6
2016 Aka JA, Calvo EL, Lin SX. Genomic data on breast cancer transcript profile modulation by 17beta-hydroxysteroid dehydrogenase type 1 and 17-beta-estradiol. Data in Brief. 9: 1000-1012. PMID 27900352 DOI: 10.1016/j.dib.2016.11.010  0.44
2016 Aka JA, Calvo EL, Lin SX. Estradiol-independent modulation of breast cancer transcript profile by 17beta-hydroxysteroid dehydrogenase type 1. Molecular and Cellular Endocrinology. PMID 27544780 DOI: 10.1016/j.mce.2016.08.026  0.44
2016 He W, Gauri M, Li T, Wang R, Lin SX. Current knowledge of the multifunctional 17β-hydroxysteroid dehydrogenase type 1 (HSD17B1). Gene. PMID 27102893 DOI: 10.1016/j.gene.2016.04.031  0.36
2016 Zhang B, Hu XJ, Wang XQ, Thériault JF, Zhu DW, Shang P, Labrie F, Lin SX. Human 3α-HSD3: Structural clues of 5α-DHT reverse binding and enzyme down-regulation decreasing MCF7 cell growth. The Biochemical Journal. PMID 26929402 DOI: 10.1042/BCJ20160083  0.48
2015 Zhang CY, Wang WQ, Chen J, Lin SX. Reductive 17beta-hydroxysteroid dehydrogenases which synthesize estradiol and inactivate dihydrotestosterone constitute major and concerted players in ER+ breast cancer cells. The Journal of Steroid Biochemistry and Molecular Biology. 150: 24-34. PMID 25257817 DOI: 10.1016/j.jsbmb.2014.09.017  0.44
2014 Zhang B, Zhu DW, Hu XJ, Zhou M, Shang P, Lin SX. Human 3-alpha hydroxysteroid dehydrogenase type 3 (3α-HSD3): the V54L mutation restricting the steroid alternative binding and enhancing the 20α-HSD activity. The Journal of Steroid Biochemistry and Molecular Biology. 141: 135-43. PMID 24434280 DOI: 10.1016/j.jsbmb.2014.01.003  0.6
2013 Shi R, Chen ZY, Zhu DW, Li C, Shan Y, Xu G, Lin SX. Crystal structures of human muscle fructose-1,6-bisphosphatase: novel quaternary states, enhanced AMP affinity, and allosteric signal transmission pathway. Plos One. 8: e71242. PMID 24086250 DOI: 10.1371/journal.pone.0071242  0.52
2013 Lambert AA, Azzi A, Lin SX, Allaire G, St-Gelais KP, Tremblay MJ, Gilbert C. Dendritic cell immunoreceptor is a new target for anti-AIDS drug development: identification of DCIR/HIV-1 inhibitors. Plos One. 8: e67873. PMID 23874461 DOI: 10.1371/journal.pone.0067873  0.48
2012 Zhang CY, Chen J, Yin DC, Lin SX. The contribution of 17beta-hydroxysteroid dehydrogenase type 1 to the estradiol-estrone ratio in estrogen-sensitive breast cancer cells. Plos One. 7: e29835. PMID 22253796 DOI: 10.1371/journal.pone.0029835  0.48
2011 Zhang SC, Sun M, Li T, Wang QH, Hao JH, Han Y, Hu XJ, Zhou M, Lin SX. Structure analysis of a new psychrophilic marine protease. Plos One. 6: e26939. PMID 22132082 DOI: 10.1371/journal.pone.0026939  0.6
2011 Gilbert C, Azzi A, Goyette N, Lin SX, Boivin G. Recombinant phenotyping of cytomegalovirus UL54 mutations that emerged during cell passages in the presence of either ganciclovir or foscarnet. Antimicrobial Agents and Chemotherapy. 55: 4019-27. PMID 21709106 DOI: 10.1128/AAC.00334-11  0.48
2011 Zhang CY, Mazumdar M, Zhu DW, Yin DC, Lin SX. Analysis and statistics of crystallisation success increase by composition modification of protein and precipitant mixing ratio. Protein and Peptide Letters. 18: 991-6. PMID 21592082  0.48
2010 Lin SX, Chen J, Mazumdar M, Poirier D, Wang C, Azzi A, Zhou M. Molecular therapy of breast cancer: progress and future directions. Nature Reviews. Endocrinology. 6: 485-93. PMID 20644568 DOI: 10.1038/nrendo.2010.92  0.6
2010 Martin M, Azzi A, Lin SX, Boivin G. Opposite effect of two cytomegalovirus DNA polymerase mutations on replicative capacity and polymerase activity. Antiviral Therapy. 15: 579-86. PMID 20587851 DOI: 10.3851/IMP1565  0.48
2009 Mazumdar M, Fournier D, Zhu DW, Cadot C, Poirier D, Lin SX. Binary and ternary crystal structure analyses of a novel inhibitor with 17beta-HSD type 1: a lead compound for breast cancer therapy. The Biochemical Journal. 424: 357-66. PMID 19929851 DOI: 10.1042/BJ20091020  0.48
2009 Bao R, Zhou CZ, Jiang C, Lin SX, Chi CW, Chen Y. The ternary structure of the double-headed arrowhead protease inhibitor API-A complexed with two trypsins reveals a novel reactive site conformation. The Journal of Biological Chemistry. 284: 26676-84. PMID 19640842 DOI: 10.1074/jbc.M109.022095  0.44
2009 Azzi A, Wang T, Zhu DW, Zou YS, Liu WY, Lin SX. Crystal structure of native cinnamomin isoform III and its comparison with other ribosome inactivating proteins. Proteins. 74: 250-5. PMID 18837036 DOI: 10.1002/prot.22251  0.48
2007 Azzi A, Lin SX. Structure function analysis of west nile virus RNA dependent RNA polymerase: molecular model and implications for drug design. Medicinal Chemistry (ShāRiqah (United Arab Emirates)). 3: 455-9. PMID 17897070  0.48
2007 Qiu W, Zhou M, Mazumdar M, Azzi A, Ghanmi D, Luu-The V, Labrie F, Lin SX. Structure-based inhibitor design for an enzyme that binds different steroids: a potent inhibitor for human type 5 17beta-hydroxysteroid dehydrogenase. The Journal of Biological Chemistry. 282: 8368-79. PMID 17166832 DOI: 10.1074/jbc.M606784200  0.6
2006 Shi R, Azzi A, Gilbert C, Boivin G, Lin SX. Three-dimensional modeling of cytomegalovirus DNA polymerase and preliminary analysis of drug resistance. Proteins. 64: 301-7. PMID 16705640 DOI: 10.1002/prot.21005  0.52
2006 Poirier D, Chang HJ, Azzi A, Boivin RP, Lin SX. Estrone and estradiol C-16 derivatives as inhibitors of type 1 17beta-hydroxysteroid dehydrogenase. Molecular and Cellular Endocrinology. 248: 236-8. PMID 16337735 DOI: 10.1016/j.mce.2005.10.017  0.6
2005 Poirier D, Boivin RP, Tremblay MR, Bérubé M, Qiu W, Lin SX. Estradiol-adenosine hybrid compounds designed to inhibit type 1 17beta-hydroxysteroid dehydrogenase. Journal of Medicinal Chemistry. 48: 8134-47. PMID 16366595 DOI: 10.1021/jm058235e  0.6
2004 Qiu W, Shi R, Lu ML, Zhou M, Roy PH, Lapointe J, Lin SX. Crystal structure of chloramphenicol acetyltransferase B2 encoded by the multiresistance transposon Tn2424. Proteins. 57: 858-61. PMID 15390264 DOI: 10.1002/prot.20250  0.6
2004 Azzi A, Lin SX. Human SARS-coronavirus RNA-dependent RNA polymerase: activity determinants and nucleoside analogue inhibitors. Proteins. 57: 12-4. PMID 15326590 DOI: 10.1002/prot.20194  0.48
2004 Qiu W, Zhou M, Labrie F, Lin SX. Crystal structures of the multispecific 17beta-hydroxysteroid dehydrogenase type 5: critical androgen regulation in human peripheral tissues. Molecular Endocrinology (Baltimore, Md.). 18: 1798-807. PMID 15087468 DOI: 10.1210/me.2004-0032  0.6
2004 Shi R, Lin SX. Cofactor hydrogen bonding onto the protein main chain is conserved in the short chain dehydrogenase/reductase family and contributes to nicotinamide orientation. The Journal of Biological Chemistry. 279: 16778-85. PMID 14966133 DOI: 10.1074/jbc.M313156200  0.52
2004 Chang HJ, Shi R, Rehse P, Lin SX. Identifying androsterone (ADT) as a cognate substrate for human dehydroepiandrosterone sulfotransferase (DHEA-ST) important for steroid homeostasis: structure of the enzyme-ADT complex. The Journal of Biological Chemistry. 279: 2689-96. PMID 14573603 DOI: 10.1074/jbc.M310446200  0.6
2003 Nahoum V, Gangloff A, Shi R, Lin SX. How estrogen-specific proteins discriminate estrogens from androgens: a common steroid binding site architecture. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 1334-6. PMID 12759331 DOI: 10.1096/fj.02-0524fje  0.72
2003 Labrie F, Luu-The V, Labrie C, Bélanger A, Simard J, Lin SX, Pelletier G. Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone. Endocrine Reviews. 24: 152-82. PMID 12700178 DOI: 10.1210/er.2001-0031  0.32
2003 Gangloff A, Shi R, Nahoum V, Lin SX. Pseudo-symmetry of C19 steroids, alternative binding orientations, and multispecificity in human estrogenic 17beta-hydroxysteroid dehydrogenase. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 274-6. PMID 12490543 DOI: 10.1096/fj.02-0397fje  0.72
2002 Qiu W, Campbell RL, Gangloff A, Dupuis P, Boivin RP, Tremblay MR, Poirier D, Lin SX. A concerted, rational design of type 1 17beta-hydroxysteroid dehydrogenase inhibitors: estradiol-adenosine hybrids with high affinity. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 16: 1829-31. PMID 12223444 DOI: 10.1096/fj.02-0026fje  0.72
2002 Zhou M, Qiu W, Chang HJ, Gangloff A, Lin SX. Purification, crystallization and preliminary X-ray diffraction results of human 17beta-hydroxysteroid dehydrogenase type 5. Acta Crystallographica. Section D, Biological Crystallography. 58: 1048-50. PMID 12037313  0.72
2002 Rehse PH, Zhou M, Lin SX. Crystal structure of human dehydroepiandrosterone sulphotransferase in complex with substrate. The Biochemical Journal. 364: 165-71. PMID 11988089  0.6
2002 Lu ML, Huang YW, Lin SX. Purification, reconstitution, and steady-state kinetics of the trans-membrane 17 beta-hydroxysteroid dehydrogenase 2. The Journal of Biological Chemistry. 277: 22123-30. PMID 11940569 DOI: 10.1074/jbc.M111726200  0.72
2001 Huang YW, Pineau I, Chang HJ, Azzi A, Bellemare V, Laberge S, Lin SX. Critical residues for the specificity of cofactors and substrates in human estrogenic 17beta-hydroxysteroid dehydrogenase 1: variants designed from the three-dimensional structure of the enzyme. Molecular Endocrinology (Baltimore, Md.). 15: 2010-20. PMID 11682630 DOI: 10.1210/mend.15.11.0730  0.72
2001 Zhou M, Rehse P, Chang HJ, Luu-The V, Lin SX. Crystallization and preliminary crystallographic results of apo and complex forms of human dehydroepiandrosterone sulfotransferase. Acta Crystallographica. Section D, Biological Crystallography. 57: 1630-3. PMID 11679728  0.6
2001 Nahoum V, Gangloff A, Legrand P, Zhu DW, Cantin L, Zhorov BS, Luu-The V, Labrie F, Breton R, Lin SX. Structure of the human 3alpha-hydroxysteroid dehydrogenase type 3 in complex with testosterone and NADP at 1.25-A resolution. The Journal of Biological Chemistry. 276: 42091-8. PMID 11514561 DOI: 10.1074/jbc.M105610200  0.72
2001 Chang HJ, Zhou M, Lin SX. Human dehydroepiandrosterone sulfotransferase: purification and characterization of a recombinant protein. The Journal of Steroid Biochemistry and Molecular Biology. 77: 159-65. PMID 11377982  0.6
2001 Gangloff A, Garneau A, Huang YW, Yang F, Lin SX. Human oestrogenic 17beta-hydroxysteroid dehydrogenase specificity: enzyme regulation through an NADPH-dependent substrate inhibition towards the highly specific oestrone reduction. The Biochemical Journal. 356: 269-76. PMID 11336660  0.72
2000 Lin SX, Han Q, Azzi A, Zhu D, Gangloff A, Campbell RL. 3D-structure of human estrogenic 17beta-HSD1: binding with various steroids. The Journal of Steroid Biochemistry and Molecular Biology. 73: 183. PMID 10925218  0.72
2000 Huang YW, Lu ML, Qi H, Lin SX. Membrane-bound human 3beta-hydroxysteroid dehydrogenase: overexpression with His-tag using a baculovirus system and single-step purification. Protein Expression and Purification. 18: 169-74. PMID 10686147 DOI: 10.1006/prep.1999.1180  0.72
2000 Han Q, Campbell RL, Gangloff A, Huang YW, Lin SX. Dehydroepiandrosterone and dihydrotestosterone recognition by human estrogenic 17beta-hydroxysteroid dehydrogenase. C-18/c-19 steroid discrimination and enzyme-induced strain. The Journal of Biological Chemistry. 275: 1105-11. PMID 10625652  0.72
1999 Lin SX, Han Q, Azzi A, Zhu DW, Gangloff A, Campbell RL, Gongloff A. 3D-structure of human estrogenic 17beta-HSD1: binding with various steroids. The Journal of Steroid Biochemistry and Molecular Biology. 69: 425-9. PMID 10419021  0.72
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