Martha H. Stipanuk - Publications

Affiliations: 
Cornell University, Ithaca, NY, United States 
Area:
Nutrition, Biochemistry

55 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Mazor KM, Dong L, Mao Y, Swanda RV, Qian SB, Stipanuk MH. Effects of single amino acid deficiency on mRNA translation are markedly different for methionine versus leucine. Scientific Reports. 8: 8076. PMID 29795412 DOI: 10.1038/s41598-018-26254-2  0.4
2018 Asano A, Roman HB, Hirschberger LL, Ushiyama A, Nelson JL, Hinchman MM, Stipanuk MH, Travis AJ. Cysteine dioxygenase is essential for mouse sperm osmoadaptation and male fertility. The Febs Journal. PMID 29604178 DOI: 10.1111/febs.14449  0.72
2017 Stipanuk MH, Jurkowska H, Niewiadomski J, Mazor KM, Roman HB, Hirschberger LL. Identification of Taurine-Responsive Genes in Murine Liver Using the Cdo1-Null Mouse Model. Advances in Experimental Medicine and Biology. 975: 475-495. PMID 28849476 DOI: 10.1007/978-94-024-1079-2_38  0.72
2016 Mazor KM, Stipanuk MH. GCN2- and eIF2α-phosphorylation-independent, but ATF4-dependent, induction of CARE-containing genes in methionine-deficient cells. Amino Acids. PMID 27613409 DOI: 10.1007/s00726-016-2318-9  0.4
2016 Driggers CM, Kean KM, Hirschberger LL, Cooley RB, Stipanuk MH, Karplus PA. Structure-based insights into the role of the Cys-Tyr crosslink and inhibitor-recognition by Mammalian Cysteine Dioxygenase. Journal of Molecular Biology. PMID 27477048 DOI: 10.1016/j.jmb.2016.07.012  0.72
2016 Niewiadomski J, Zhou JQ, Roman HB, Liu X, Hirschberger LL, Locasale JW, Stipanuk MH. Effects of a block in cysteine catabolism on energy balance and fat metabolism in mice. Annals of the New York Academy of Sciences. 1363: 99-115. PMID 26995761 DOI: 10.1111/nyas.13021  0.72
2015 Jurkowska H, Niewiadomski J, Hirschberger LL, Roman HB, Mazor KM, Liu X, Locasale JW, Park E, Stipanuk MH. Downregulation of hepatic betaine:homocysteine methyltransferase (BHMT) expression in taurine-deficient mice is reversed by taurine supplementation in vivo. Amino Acids. PMID 26481005 DOI: 10.1007/s00726-015-2108-9  0.72
2015 Stipanuk MH, Jurkowska H, Roman HB, Niewiadomski J, Hirschberger LL. Insights into Taurine Synthesis and Function Based on Studies with Cysteine Dioxygenase (CDO1) Knockout Mice. Advances in Experimental Medicine and Biology. 803: 29-39. PMID 25833485 DOI: 10.1007/978-3-319-15126-7_3  0.72
2015 Jurkowska H, Stipanuk MH, Hirschberger LL, Roman HB. Propargylglycine inhibits hypotaurine/taurine synthesis and elevates cystathionine and homocysteine concentrations in primary mouse hepatocytes. Amino Acids. 47: 1215-23. PMID 25772816 DOI: 10.1007/s00726-015-1948-7  0.72
2014 Ables GP, Brown-Borg HM, Buffenstein R, Church CD, Elshorbagy AK, Gladyshev VN, Huang TH, Miller RA, Mitchell JR, Richie JP, Rogina B, Stipanuk MH, Orentreich DS, Orentreich N. The first international mini-symposium on methionine restriction and lifespan. Frontiers in Genetics. 5: 122. PMID 24847356 DOI: 10.3389/fgene.2014.00122  0.48
2014 Jurkowska H, Roman HB, Hirschberger LL, Sasakura K, Nagano T, Hanaoka K, Krijt J, Stipanuk MH. Primary hepatocytes from mice lacking cysteine dioxygenase show increased cysteine concentrations and higher rates of metabolism of cysteine to hydrogen sulfide and thiosulfate. Amino Acids. 46: 1353-65. PMID 24609271 DOI: 10.1007/s00726-014-1700-8  0.48
2014 Sikalidis AK, Mazor KM, Lee JI, Roman HB, Hirschberger LL, Stipanuk MH. Upregulation of capacity for glutathione synthesis in response to amino acid deprivation: regulation of glutamate-cysteine ligase subunits. Amino Acids. 46: 1285-96. PMID 24557597 DOI: 10.1007/s00726-014-1687-1  1
2014 Kerr TA, Matsumoto Y, Matsumoto H, Xie Y, Hirschberger LL, Stipanuk MH, Anakk S, Moore DD, Watanabe M, Kennedy S, Davidson NO. Cysteine sulfinic acid decarboxylase regulation: A role for farnesoid X receptor and small heterodimer partner in murine hepatic taurine metabolism. Hepatology Research : the Official Journal of the Japan Society of Hepatology. 44: E218-28. PMID 24033844 DOI: 10.1111/hepr.12230  0.48
2013 Sikalidis AK, Mazor KM, Kang M, Liu H, Stipanuk MH. Total 4EBP1 Is Elevated in Liver of Rats in Response to Low Sulfur Amino Acid Intake. Journal of Amino Acids. 2013: 864757. PMID 24089634 DOI: 10.1155/2013/864757  1
2013 Driggers CM, Cooley RB, Sankaran B, Hirschberger LL, Stipanuk MH, Karplus PA. Cysteine dioxygenase structures from pH4 to 9: consistent cys-persulfenate formation at intermediate pH and a Cys-bound enzyme at higher pH. Journal of Molecular Biology. 425: 3121-36. PMID 23747973 DOI: 10.1016/j.jmb.2013.05.028  0.48
2013 Roman HB, Hirschberger LL, Krijt J, Valli A, Kožich V, Stipanuk MH. The cysteine dioxgenase knockout mouse: altered cysteine metabolism in nonhepatic tissues leads to excess H2S/HS(-) production and evidence of pancreatic and lung toxicity. Antioxidants & Redox Signaling. 19: 1321-36. PMID 23350603 DOI: 10.1089/ars.2012.5010  0.72
2012 Ueki I, Roman HB, Hirschberger LL, Junior C, Stipanuk MH. Extrahepatic tissues compensate for loss of hepatic taurine synthesis in mice with liver-specific knockout of cysteine dioxygenase. American Journal of Physiology. Endocrinology and Metabolism. 302: E1292-9. PMID 22414809 DOI: 10.1152/ajpendo.00589.2011  0.72
2011 Ueki I, Roman HB, Valli A, Fieselmann K, Lam J, Peters R, Hirschberger LL, Stipanuk MH. Knockout of the murine cysteine dioxygenase gene results in severe impairment in ability to synthesize taurine and an increased catabolism of cysteine to hydrogen sulfide. American Journal of Physiology. Endocrinology and Metabolism. 301: E668-84. PMID 21693692 DOI: 10.1152/ajpendo.00151.2011  0.72
2011 Sikalidis AK, Lee JI, Stipanuk MH. Gene expression and integrated stress response in HepG2/C3A cells cultured in amino acid deficient medium. Amino Acids. 41: 159-71. PMID 20361218 DOI: 10.1007/s00726-010-0571-x  1
2011 Stipanuk MH, Simmons CR, Karplus PA, Dominy JE. Thiol dioxygenases: unique families of cupin proteins. Amino Acids. 41: 91-102. PMID 20195658 DOI: 10.1007/s00726-010-0518-2  0.48
2011 Stipanuk MH, Ueki I. Dealing with methionine/homocysteine sulfur: cysteine metabolism to taurine and inorganic sulfur. Journal of Inherited Metabolic Disease. 34: 17-32. PMID 20162368 DOI: 10.1007/s10545-009-9006-9  0.56
2010 Sikalidis AK, Stipanuk MH. Growing rats respond to a sulfur amino acid-deficient diet by phosphorylation of the alpha subunit of eukaryotic initiation factor 2 heterotrimeric complex and induction of adaptive components of the integrated stress response. The Journal of Nutrition. 140: 1080-5. PMID 20357079 DOI: 10.3945/jn.109.120428  1
2009 Ueki I, Stipanuk MH. 3T3-L1 adipocytes and rat adipose tissue have a high capacity for taurine synthesis by the cysteine dioxygenase/cysteinesulfinate decarboxylase and cysteamine dioxygenase pathways. The Journal of Nutrition. 139: 207-14. PMID 19106324 DOI: 10.3945/jn.108.099085  0.56
2009 Stipanuk MH, Ueki I, Dominy JE, Simmons CR, Hirschberger LL. Cysteine dioxygenase: a robust system for regulation of cellular cysteine levels. Amino Acids. 37: 55-63. PMID 19011731 DOI: 10.1007/s00726-008-0202-y  0.48
2008 Stipanuk MH, Dominy JE, Ueki I, Hirschberger LL. Measurement of Cysteine Dioxygenase Activity and Protein Abundance. Current Protocols in Toxicology / Editorial Board, Mahin D. Maines (Editor-in-Chief) ... [Et Al.]. 38: 6.15.1-6.15.25. PMID 19885389 DOI: 10.1002/0471140856.tx0615s38  0.92
2008 Simmons CR, Krishnamoorthy K, Granett SL, Schuller DJ, Dominy JE, Begley TP, Stipanuk MH, Karplus PA. A putative Fe2+-bound persulfenate intermediate in cysteine dioxygenase. Biochemistry. 47: 11390-2. PMID 18847220 DOI: 10.1021/bi801546n  0.48
2008 Dominy JE, Hwang J, Guo S, Hirschberger LL, Zhang S, Stipanuk MH. Synthesis of amino acid cofactor in cysteine dioxygenase is regulated by substrate and represents a novel post-translational regulation of activity. The Journal of Biological Chemistry. 283: 12188-201. PMID 18308719 DOI: 10.1074/jbc.M800044200  0.92
2008 Lee JI, Dominy JE, Sikalidis AK, Hirschberger LL, Wang W, Stipanuk MH. HepG2/C3A cells respond to cysteine deprivation by induction of the amino acid deprivation/integrated stress response pathway. Physiological Genomics. 33: 218-29. PMID 18285520 DOI: 10.1152/physiolgenomics.00263.2007  1
2007 Ueki I, Stipanuk MH. Enzymes of the taurine biosynthetic pathway are expressed in rat mammary gland. The Journal of Nutrition. 137: 1887-94. PMID 17634260  0.56
2007 Dominy JE, Simmons CR, Hirschberger LL, Hwang J, Coloso RM, Stipanuk MH. Discovery and characterization of a second mammalian thiol dioxygenase, cysteamine dioxygenase. The Journal of Biological Chemistry. 282: 25189-98. PMID 17581819 DOI: 10.1074/jbc.M703089200  0.48
2007 Dominy JE, Hwang J, Stipanuk MH. Overexpression of cysteine dioxygenase reduces intracellular cysteine and glutathione pools in HepG2/C3A cells. American Journal of Physiology. Endocrinology and Metabolism. 293: E62-9. PMID 17327371 DOI: 10.1152/ajpendo.00053.2007  0.92
2006 Dominy JE, Hirschberger LL, Coloso RM, Stipanuk MH. In vivo regulation of cysteine dioxygenase via the ubiquitin-26S proteasome system. Advances in Experimental Medicine and Biology. 583: 37-47. PMID 17153587  0.92
2006 Coloso RM, Hirschberger LL, Dominy JE, Lee JI, Stipanuk MH. Cysteamine dioxygenase: evidence for the physiological conversion of cysteamine to hypotaurine in rat and mouse tissues. Advances in Experimental Medicine and Biology. 583: 25-36. PMID 17153586  0.96
2006 Ko KS, Tôrres CL, Fascetti AJ, Stipanuk MH, Hirschberger L, Rogers QR. Copper deficiency does not lead to taurine deficiency in rats. The Journal of Nutrition. 136: 2502-5. PMID 16988117  0.48
2006 Dominy JE, Simmons CR, Karplus PA, Gehring AM, Stipanuk MH. Identification and characterization of bacterial cysteine dioxygenases: a new route of cysteine degradation for eubacteria. Journal of Bacteriology. 188: 5561-9. PMID 16855246 DOI: 10.1128/JB.00291-06  0.48
2006 Stipanuk MH, Dominy JE, Lee JI, Coloso RM. Mammalian cysteine metabolism: new insights into regulation of cysteine metabolism. The Journal of Nutrition. 136: 1652S-1659S. PMID 16702335  0.96
2006 Stipanuk MH, Dominy JE. Surprising insights that aren't so surprising in the modeling of sulfur amino acid metabolism. Amino Acids. 30: 251-6. PMID 16680556 DOI: 10.1007/s00726-005-0288-4  0.92
2006 Simmons CR, Liu Q, Huang Q, Hao Q, Begley TP, Karplus PA, Stipanuk MH. Crystal structure of mammalian cysteine dioxygenase. A novel mononuclear iron center for cysteine thiol oxidation. The Journal of Biological Chemistry. 281: 18723-33. PMID 16611640 DOI: 10.1074/jbc.M601555200  0.48
2006 Simmons CR, Hirschberger LL, Machi MS, Stipanuk MH. Expression, purification, and kinetic characterization of recombinant rat cysteine dioxygenase, a non-heme metalloenzyme necessary for regulation of cellular cysteine levels. Protein Expression and Purification. 47: 74-81. PMID 16325423 DOI: 10.1016/j.pep.2005.10.025  0.48
2006 Dominy JE, Hirschberger LL, Coloso RM, Stipanuk MH. Regulation of cysteine dioxygenase degradation is mediated by intracellular cysteine levels and the ubiquitin-26 S proteasome system in the living rat. The Biochemical Journal. 394: 267-73. PMID 16262602 DOI: 10.1042/BJ20051510  0.92
2006 Lee JI, Kang J, Stipanuk MH. Differential regulation of glutamate-cysteine ligase subunit expression and increased holoenzyme formation in response to cysteine deprivation. The Biochemical Journal. 393: 181-90. PMID 16137247 DOI: 10.1042/BJ20051111  0.96
2005 Simmons CR, Hao Q, Stipanuk MH. Preparation, crystallization and X-ray diffraction analysis to 1.5 A resolution of rat cysteine dioxygenase, a mononuclear iron enzyme responsible for cysteine thiol oxidation. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 61: 1013-6. PMID 16511222 DOI: 10.1107/S1744309105033737  0.48
2004 Dominy JE, Stipanuk MH. New roles for cysteine and transsulfuration enzymes: production of H2S, a neuromodulator and smooth muscle relaxant. Nutrition Reviews. 62: 348-53. PMID 15497768  0.92
2004 Lee JI, Londono M, Hirschberger LL, Stipanuk MH. Regulation of cysteine dioxygenase and gamma-glutamylcysteine synthetase is associated with hepatic cysteine level. The Journal of Nutritional Biochemistry. 15: 112-22. PMID 14972351 DOI: 10.1016/j.jnutbio.2003.10.005  0.96
2004 Stipanuk MH, Hirschberger LL, Londono MP, Cresenzi CL, Yu AF. The ubiquitin-proteasome system is responsible for cysteine-responsive regulation of cysteine dioxygenase concentration in liver. American Journal of Physiology. Endocrinology and Metabolism. 286: E439-48. PMID 14644768 DOI: 10.1152/ajpendo.00336.2003  0.72
2003 Cresenzi CL, Lee JI, Stipanuk MH. Cysteine is the metabolic signal responsible for dietary regulation of hepatic cysteine dioxygenase and glutamate cysteine ligase in intact rats. The Journal of Nutrition. 133: 2697-702. PMID 12949352  0.96
2002 Stipanuk MH, Londono M, Lee JI, Hu M, Yu AF. Enzymes and metabolites of cysteine metabolism in nonhepatic tissues of rats show little response to changes in dietary protein or sulfur amino acid levels. The Journal of Nutrition. 132: 3369-78. PMID 12421853  0.96
2001 Hirschberger LL, Daval S, Stover PJ, Stipanuk MH. Murine cysteine dioxygenase gene: Structural organization, tissue-specific expression and promoter identification Gene. 277: 153-161. PMID 11602353 DOI: 10.1016/S0378-1119(01)00691-6  0.48
1992 Stipanuk MH, Coloso RM, Garcia RA, Banks MF. Cysteine concentration regulates cysteine metabolism to glutathione, sulfate and taurine in rat hepatocytes. The Journal of Nutrition. 122: 420-7. PMID 1542000 DOI: 10.1093/jn/122.3.420  0.72
1991 Moise NS, Pacioretty LM, Kallfelz FA, Stipanuk MH, King JM, Gilmour RF. Dietary taurine deficiency and dilated cardiomyopathy in the fox. American Heart Journal. 121: 541-7. PMID 1990761 DOI: 10.1016/0002-8703(91)90724-V  0.48
1990 Rao AM, Drake MR, Stipanuk MH. Role of the transsulfuration pathway and of γ-cystathionase activity in the formation of cysteine and sulfate from methionine in rat hepatocytes Journal of Nutrition. 120: 837-845. PMID 2116506 DOI: 10.1093/jn/120.8.837  0.48
1988 Garcia RA, Hirschberger LL, Stipanuk MH. Measurement of cyst(e)amine in physiological samples by high performance liquid chromatography. Analytical Biochemistry. 170: 432-40. PMID 3394941 DOI: 10.1016/0003-2697(88)90655-0  0.72
1986 Rentschler LA, Hirschberger LL, Stipanuk MH. Response of the kitten to dietary taurine depletion: effects on renal reabsorption, bile acid conjugation and activities of enzymes involved in taurine synthesis. Comparative Biochemistry and Physiology. B, Comparative Biochemistry. 84: 319-25. PMID 3743026 DOI: 10.1016/0305-0491(86)90084-2  0.72
1982 Daniels KM, Stipanuk MH. The effect of dietary cysteine level on cysteine metabolism in rats Journal of Nutrition. 112: 2130-2141. PMID 7131091 DOI: 10.1093/jn/112.11.2130  0.48
1982 Stipanuk MH, King KM. Characteristics of the enzymatic capacity for cysteine desulfhydration in cat tissues Comparative Biochemistry and Physiology -- Part B: Biochemistry And. 73: 595-601. PMID 6960976 DOI: 10.1016/0305-0491(82)90081-5  0.48
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