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Mark Spaller - Publications

Affiliations: 
Wayne State University, Detroit, MI, United States 
Area:
Biochemistry
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31 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Knafo S, Sánchez-Puelles C, Palomer E, Delgado I, Draffin JE, Mingo J, Wahle T, Kaleka K, Mou L, Pereda-Perez I, Klosi E, Faber EB, Chapman HM, Lozano-Montes L, Ortega-Molina A, ... ... Spaller MR, et al. PTEN recruitment controls synaptic and cognitive function in Alzheimer's models. Nature Neuroscience. PMID 26780512 DOI: 10.1038/nn.4225  0.4
2015 Marshall J, Wong KY, Rupasinghe CN, Tiwari R, Zhao X, Berberoglu ED, Sinkler C, Liu J, Lee I, Parang K, Spaller MR, Hüttemann M, Goebel DJ. Inhibition of N-Methyl-D-Aspartate-Induced Retinal Neuronal Death by Polyarginine Peptides is Linked to the Attenuation of Stress-Induced Hyperpolarization of the Inner Mitochondrial Membrane Potential. The Journal of Biological Chemistry. PMID 26100636 DOI: 10.1074/jbc.M115.662791  0.64
2015 Patra CR, Rupasinghe CN, Dutta SK, Bhattacharya S, Wang E, Spaller MR, Mukhopadhyay D. Chemically-Modified Peptides Targeting the PDZ Domain of GIPC as a Therapeutic Approach for Cancer. Acs Chemical Biology. PMID 25756300 DOI: 10.1021/cb500865a  0.64
2014 Bhattacharya S, Pal K, Sharma AK, Dutta SK, Lau JS, Yan IK, Wang E, Elkhanany A, Alkharfy KM, Sanyal A, Patel TC, Chari ST, Spaller MR, Mukhopadhyay D. GAIP interacting protein C-terminus regulates autophagy and exosome biogenesis of pancreatic cancer through metabolic pathways. Plos One. 9: e114409. PMID 25469510 DOI: 10.1371/journal.pone.0114409  0.64
2014 Amacher JF, Zhao R, Spaller MR, Madden DR. Chemically modified peptide scaffolds target the CFTR-associated ligand PDZ domain. Plos One. 9: e103650. PMID 25136860 DOI: 10.1371/journal.pone.0103650  0.64
2014 Pal K, Pletnev AA, Dutta SK, Wang E, Zhao R, Baral A, Yadav VK, Aggarwal S, Krishnaswamy S, Alkharfy KM, Chowdhury S, Spaller MR, Mukhopadhyay D. Inhibition of endoglin-GIPC interaction inhibits pancreatic cancer cell growth. Molecular Cancer Therapeutics. 13: 2264-75. PMID 25125675 DOI: 10.1158/1535-7163.MCT-14-0291  0.64
2013 Yedidi RS, Muhuhi JM, Liu Z, Bencze KZ, Koupparis K, O'Connor CE, Kovari IA, Spaller MR, Kovari LC. Design, synthesis and evaluation of a potent substrate analog inhibitor identified by scanning Ala/Phe mutagenesis, mimicking substrate co-evolution, against multidrug-resistant HIV-1 protease. Biochemical and Biophysical Research Communications. 438: 703-8. PMID 23921229 DOI: 10.1016/j.bbrc.2013.07.117  0.64
2013 Cao C, Rioult-Pedotti MS, Migani P, Yu CJ, Tiwari R, Parang K, Spaller MR, Goebel DJ, Marshall J. Impairment of TrkB-PSD-95 signaling in Angelman syndrome. Plos Biology. 11: e1001478. PMID 23424281 DOI: 10.1371/journal.pbio.1001478  0.64
2013 Kaur M, Rupasinghe CN, Klosi E, Spaller MR, Chow CS. Selection of heptapeptides that bind helix 69 of bacterial 23S ribosomal RNA. Bioorganic & Medicinal Chemistry. 21: 1240-7. PMID 23375098 DOI: 10.1016/j.bmc.2012.12.048  0.64
2012 Patra CR, Rupasinghe CN, Dutta SK, Bhattacharya S, Wang E, Spaller MR, Mukhopadhyay D. Chemically modified peptides targeting the PDZ domain of GIPC as a therapeutic approach for cancer. Acs Chemical Biology. 7: 770-9. PMID 22292614 DOI: 10.1021/cb200536r  0.64
2010 Wang L, Lau JS, Patra CR, Cao Y, Bhattacharya S, Dutta S, Nandy D, Wang E, Rupasinghe CN, Vohra P, Spaller MR, Mukhopadhyay D. RGS-GAIP-interacting protein controls breast cancer progression. Molecular Cancer Research : McR. 8: 1591-600. PMID 21047775 DOI: 10.1158/1541-7786.MCR-10-0209  0.64
2010 Rubini C, Ruzza P, Spaller MR, Siligardi G, Hussain R, Udugamasooriya DG, Bellanda M, Mammi S, Borgogno A, Calderan A, Cesaro L, Brunati AM, Donella-Deana A. Recognition of lysine-rich peptide ligands by murine cortactin SH3 domain: CD, ITC, and NMR studies. Biopolymers. 94: 298-306. PMID 19921743 DOI: 10.1002/bip.21350  0.96
2009 Li M, Duc AC, Klosi E, Pattabiraman S, Spaller MR, Chow CS. Selection of peptides that target the aminoacyl-tRNA site of bacterial 16S ribosomal RNA. Biochemistry. 48: 8299-311. PMID 19645415 DOI: 10.1021/bi900982t  0.64
2009 Muders MH, Vohra PK, Dutta SK, Wang E, Ikeda Y, Wang L, Udugamasooriya DG, Memic A, Rupasinghe CN, Rupashinghe CN, Baretton GB, Aust DE, Langer S, Datta K, Simons M, ... Spaller MR, et al. Targeting GIPC/synectin in pancreatic cancer inhibits tumor growth. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 4095-103. PMID 19509165 DOI: 10.1158/1078-0432.CCR-08-2837  0.64
2009 Sharma SC, Memic A, Rupasinghe CN, Duc AC, Spaller MR. T7 phage display as a method of peptide ligand discovery for PDZ domain proteins. Biopolymers. 92: 183-93. PMID 19235856 DOI: 10.1002/bip.21172  0.64
2008 Memic A, Spaller MR. How do halogen substituents contribute to protein-binding interactions? A thermodynamic study of peptide ligands with diverse aryl halides. Chembiochem : a European Journal of Chemical Biology. 9: 2793-5. PMID 18985647 DOI: 10.1002/cbic.200800572  0.92
2008 Udugamasooriya DG, Sharma SC, Spaller MR. A chemical library approach to organic-modified peptide ligands for PDZ domain proteins: a synthetic, thermodynamic and structural investigation. Chembiochem : a European Journal of Chemical Biology. 9: 1587-9. PMID 18506876 DOI: 10.1002/cbic.200800126  0.96
2008 Udugamasooriya DG, Spaller MR. Conformational constraint in protein ligand design and the inconsistency of binding entropy. Biopolymers. 89: 653-67. PMID 18335423 DOI: 10.1002/bip.20983  0.96
2007 Sharma SC, Rupasinghe CN, Parisien RB, Spaller MR. Design, synthesis, and evaluation of linear and cyclic peptide ligands for PDZ10 of the multi-PDZ domain protein MUPP1. Biochemistry. 46: 12709-20. PMID 17939682 DOI: 10.1021/bi7008135  0.64
2007 Klosi E, Saro D, Spaller MR. Bivalent peptides as PDZ domain ligands. Bioorganic & Medicinal Chemistry Letters. 17: 6147-50. PMID 17890086 DOI: 10.1016/j.bmcl.2007.09.035  0.4
2007 Saro D, Li T, Rupasinghe C, Paredes A, Caspers N, Spaller MR. A thermodynamic ligand binding study of the third PDZ domain (PDZ3) from the mammalian neuronal protein PSD-95. Biochemistry. 46: 6340-52. PMID 17474715 DOI: 10.1021/bi062088k  0.4
2006 Piserchio A, Spaller M, Mierke DF. Targeting the PDZ domains of molecular scaffolds of transmembrane ion channels. The Aaps Journal. 8: E396-401. PMID 16796391 DOI: 10.1208/aapsj080245  0.64
2006 Cook JD, Bencze KZ, Jankovic AD, Crater AK, Busch CN, Bradley PB, Stemmler AJ, Spaller MR, Stemmler TL. Monomeric yeast frataxin is an iron-binding protein. Biochemistry. 45: 7767-77. PMID 16784228 DOI: 10.1021/bi060424r  0.64
2006 Rupasinghe CN, Spaller MR. The interplay between structure-based design and combinatorial chemistry. Current Opinion in Chemical Biology. 10: 188-93. PMID 16616591 DOI: 10.1016/j.cbpa.2006.03.014  0.64
2006 Gerges NZ, Backos DS, Rupasinghe CN, Spaller MR, Esteban JA. Dual role of the exocyst in AMPA receptor targeting and insertion into the postsynaptic membrane. The Embo Journal. 25: 1623-34. PMID 16601687 DOI: 10.1038/sj.emboj.7601065  0.64
2005 Udugamasooriya G, Saro D, Spaller MR. Bridged peptide macrocycles as ligands for PDZ domain proteins. Organic Letters. 7: 1203-6. PMID 15787467 DOI: 10.1021/ol0475966  0.4
2004 Saro D, Klosi E, Paredes A, Spaller MR. Thermodynamic analysis of a hydrophobic binding site: probing the PDZ domain with nonproteinogenic peptide ligands. Organic Letters. 6: 3429-32. PMID 15387515 DOI: 10.1021/ol049181q  0.4
2004 Piserchio A, Salinas GD, Li T, Marshall J, Spaller MR, Mierke DF. Targeting specific PDZ domains of PSD-95; structural basis for enhanced affinity and enzymatic stability of a cyclic peptide. Chemistry & Biology. 11: 469-73. PMID 15123241 DOI: 10.1016/j.chembiol.2004.03.013  0.64
2004 Li T, Saro D, Spaller MR. Thermodynamic profiling of conformationally constrained cyclic ligands for the PDZ domain. Bioorganic & Medicinal Chemistry Letters. 14: 1385-8. PMID 15006367 DOI: 10.1016/j.bmcl.2003.09.103  0.4
2002 Spaller MR, Thielemann WT, Brennan PE, Bartlett PA. Combinatorial synthetic design. Solution and polymer-supported synthesis of heterocycles via intramolecular aza Diels-Alder and imino alcohol cyclizations. Journal of Combinatorial Chemistry. 4: 516-22. PMID 12217025 DOI: 10.1021/cc020027+  0.64
1997 Spaller MR, Burger MT, Fardis M, Bartlett PA. Synthetic strategies in combinatorial chemistry. Current Opinion in Chemical Biology. 1: 47-53. PMID 9667834 DOI: 10.1016/S1367-5931(97)80107-X  0.64
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