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John C. Kostyak, Ph.D. - Publications

Affiliations: 
2011 Department of Biological Sciences University of Delaware, Newark, DE, United States 
Area:
Cell Biology, General Biology, Physiology Biology
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26 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Kostyak JC, McKenzie SE, Naik UP. The Function of ASK1 in Sepsis and Stress-Induced Disorders. International Journal of Molecular Sciences. 25. PMID 38203381 DOI: 10.3390/ijms25010213  0.626
2023 Dangelmaier CA, Patchin M, Vajipayajula DN, Vari HR, Singh PK, Wright MN, Kostyak JC, Tsygankov AY, Kunapuli SP. Phosphorylation of spleen tyrosine kinase (Syk) at Y346 negatively regulates ITAM-mediated signaling and function in platelets. The Journal of Biological Chemistry. 104865. PMID 37268160 DOI: 10.1016/j.jbc.2023.104865  0.562
2022 Dangelmaier C, Mauri B, Patel A, Kunapuli SP, Kostyak JC. D121 Located within the DRY Motif of P2Y12 Is Essential for P2Y12-Mediated Platelet Function. International Journal of Molecular Sciences. 23. PMID 36232816 DOI: 10.3390/ijms231911519  0.528
2022 Kostyak JC, Mauri B, Dangelmaier C, Vari HR, Patel A, Wright M, Reddy H, Tsygankov AY, Kunapuli SP. Phosphorylation on Syk Y342 is important for both ITAM and hemITAM signaling in platelets. The Journal of Biological Chemistry. 298: 102189. PMID 35753354 DOI: 10.1016/j.jbc.2022.102189  0.518
2022 Dangelmaier C, Vari HR, Wright M, Kostyak JC, Kunapuli SP. Clustering extent-dependent differential signaling by CLEC-2 receptors in platelets. Research and Practice in Thrombosis and Haemostasis. 6: e12710. PMID 35573643 DOI: 10.1002/rth2.12710  0.308
2021 Kostyak JC, Mauri B, Patel A, Dangelmaier C, Reddy H, Kunapuli SP. Phosphorylation of protein kinase Cδ positively regulates thromboxane generation in platelets. The Journal of Biological Chemistry. 100720. PMID 33932405 DOI: 10.1016/j.jbc.2021.100720  0.593
2019 Inamdar VV, Reddy H, Dangelmaier C, Kostyak JC, Kunapuli SP. The protein tyrosine phosphatase PTPN7 is a negative regulator of ERK activation and thromboxane generation in platelets. The Journal of Biological Chemistry. PMID 31266805 DOI: 10.1074/Jbc.Ra119.007735  0.579
2019 Inamdar VV, Kostyak JC, Badolia R, Dangelmaier CA, Manne BK, Patel A, Kim S, Kunapuli SP. Impaired Glycoprotein VI-Mediated Signaling and Platelet Functional Responses in CD45 Knockout Mice. Thrombosis and Haemostasis. PMID 31226719 DOI: 10.1055/S-0039-1692422  0.346
2019 Patel A, Kostyak J, Dangelmaier C, Badolia R, Bhavanasi D, Aslan JE, Merali S, Kim S, Eble JA, Goldfinger L, Kunapuli S. ELMO1 deficiency enhances platelet function. Blood Advances. 3: 575-587. PMID 30787021 DOI: 10.1182/Bloodadvances.2018016444  0.594
2018 Kostyak JC, Mauri BR, Dangelmaier C, Patel A, Zhou Y, Eble JA, Tsygankov AY, McKenzie SE, Kunapuli SP. TULA-2 Deficiency Enhances Platelet Functional Responses to CLEC-2 Agonists. Th Open : Companion Journal to Thrombosis and Haemostasis. 2: e411-e419. PMID 31249969 DOI: 10.1055/s-0038-1676358  0.533
2018 Janapati S, Wurtzel J, Dangelmaier C, Manne BK, Bhavanasi D, Kostyak JC, Kim S, Holinstat M, Kunapuli SP, Goldfinger LE. TC21/RRas2 regulates GPVI-FcRγ-mediated platelet activation and thrombus stability. Journal of Thrombosis and Haemostasis : Jth. PMID 29883056 DOI: 10.1111/Jth.14197  0.484
2018 Kostyak JC, Mauri BR, Dangelmaier CA, Patel A, Wright M, Reddy HG, Eble JA, Kunapuli SP. Dysfunctional CLEC-2 and GPVI-Mediated Signaling in Syk Y342F Knock-in Mouse Platelets Blood. 132: 3729-3729. DOI: 10.1182/Blood-2018-99-113367  0.526
2018 Kostyak JC, Dangelmaier CA, Mauri BR, Patel A, Kunapuli SP. Severely Impaired Platelet Function Due to a Novel Mutation of P2Y12 from a Human Subject with No History of Bleeding Blood. 132: 1130-1130. DOI: 10.1182/Blood-2018-99-113015  0.464
2017 Kostyak JC, Liverani E, Kunapuli SP. PKC-epsilon deficiency alters progenitor cell populations in favor of megakaryopoiesis. Plos One. 12: e0182867. PMID 28783756 DOI: 10.1371/Journal.Pone.0182867  0.405
2017 Badolia R, Kostyak JC, Dangelmaier C, Kunapuli SP. Syk Activity Is Dispensable for Platelet GP1b-IX-V Signaling. International Journal of Molecular Sciences. 18. PMID 28598382 DOI: 10.3390/Ijms18061238  0.512
2016 Patel A, Kim S, Kostyak J, Badolia R, Dangelmaier C, Merali S, Kunapuli SP. ELMO1 Is a Novel Negative Regulator of Glycoprotein VI Signaling in Platelets Blood. 128: 2533-2533. DOI: 10.1182/Blood.V128.22.2533.2533  0.614
2016 Inamdar V, Kostyak J, Badolia R, Dangelmaier C, Kim S, Manne B, Kunapuli SP. Impaired GPVI Mediated Platelet Functional Responses and Signaling in CD45 Knockout Mice Blood. 128: 1355-1355. DOI: 10.1182/Blood.V128.22.1355.1355  0.35
2015 Kosoff RE, Aslan JE, Kostyak JC, Dulaimi E, Chow HY, Prudnikova TY, Radu M, Kunapuli SP, McCarty OJ, Chernoff J. Pak2 restrains endomitosis during megakaryopoiesis and alters cytoskeleton organization. Blood. 125: 2995-3005. PMID 25824689 DOI: 10.1182/Blood-2014-10-604504  0.498
2015 Bhavanasi D, Kostyak JC, Swindle J, Kilpatrick LE, Kunapuli SP. CGX1037 is a novel PKC isoform delta selective inhibitor in platelets. Platelets. 26: 2-9. PMID 24433221 DOI: 10.3109/09537104.2013.868877  0.508
2014 Kostyak JC, Bhavanasi D, Liverani E, McKenzie SE, Kunapuli SP. Protein kinase C δ deficiency enhances megakaryopoiesis and recovery from thrombocytopenia. Arteriosclerosis, Thrombosis, and Vascular Biology. 34: 2579-85. PMID 25359855 DOI: 10.1161/Atvbaha.114.304492  0.323
2012 Kostyak JC, Naik MU, Naik UP. Calcium- and integrin-binding protein 1 regulates megakaryocyte ploidy, adhesion, and migration. Blood. 119: 838-46. PMID 22128142 DOI: 10.1182/Blood-2011-04-346098  0.667
2012 Kunapuli SP, Kostyak JC. PKCδ Negatively Regulates Primary Megakaryocyte Proliferation and Differentiation Blood. 120: 853-853. DOI: 10.1182/Blood.V120.21.853.853  0.533
2012 Naik MU, Bachman B, Kostyak JC, Dai W, Naik UP. Polo-Like Kinase 3, a Novel Regulator of Thrombosis: Positive Regulation of TxA2 Generation, Granular Secretion and Clot Retraction, but Negative Regulation of Integrin Activation Blood. 120: 379-379. DOI: 10.1182/Blood.V120.21.379.379  0.65
2011 Kostyak JC, Naik UP. Calcium- and integrin-binding protein 1 regulates endomitosis and its interaction with Polo-like kinase 3 is enhanced in endomitotic Dami cells. Plos One. 6: e14513. PMID 21264284 DOI: 10.1371/Journal.Pone.0014513  0.583
2011 Kostyak JC, Naik UP. Dual Role for CIB1 in Thrombopoiesis: CIB1 Suppresses Megakaryocyte Quantities but Supports Adhesion, Migration, and Proplatelet Formation Blood. 118: 2384-2384. DOI: 10.1182/Blood.V118.21.2384.2384  0.684
2007 Kostyak JC, Naik UP. Megakaryopoiesis: transcriptional insights into megakaryocyte maturation. Frontiers in Bioscience : a Journal and Virtual Library. 12: 2050-62. PMID 17127443 DOI: 10.2741/2210  0.61
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