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Roberto J. Botelho, Ph.D. - Publications

Affiliations: 
2004 University of Toronto, Toronto, ON, Canada 
 2005- Ryerson University, Toronto, Ontario, Canada 
Area:
Cell Biology
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60 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Zhang K, Chan V, Botelho RJ, Antonescu CN. A tail of their own: regulation of cardiolipin and phosphatidylinositol fatty acyl profile by the acyltransferase LCLAT1. Biochemical Society Transactions. PMID 37737061 DOI: 10.1042/BST20220603  0.685
2023 Soha SA, Santhireswaran A, Huq S, Casimir-Powell J, Jenkins N, Hodgson GK, Sugiyama M, Antonescu CN, Impellizzeri S, Botelho RJ. Improved imaging and preservation of lysosome dynamics using silver nanoparticle-enhanced fluorescence. Molecular Biology of the Cell. mbcE22060200. PMID 37405751 DOI: 10.1091/mbc.E22-06-0200  0.61
2023 Mansat M, Dayam RM, Botelho RJ. Quantitative Immunofluorescence to Study Phagosome Maturation and Resolution. Methods in Molecular Biology (Clifton, N.J.). 2692: 121-137. PMID 37365465 DOI: 10.1007/978-1-0716-3338-0_9  0.308
2023 Soffiaturo S, Choy C, Botelho RJ. Quantifying Phagocytosis by Immunofluorescence and Microscopy. Methods in Molecular Biology (Clifton, N.J.). 2692: 25-39. PMID 37365459 DOI: 10.1007/978-1-0716-3338-0_3  0.355
2023 Boutry M, DiGiovanni LF, Demers N, Fountain A, Mamand S, Botelho RJ, Kim PK. Arf1-PI4KIIIβ positive vesicles regulate PI(3)P signaling to facilitate lysosomal tubule fission. The Journal of Cell Biology. 222. PMID 37289133 DOI: 10.1083/jcb.202205128  0.306
2022 Lo L, Uchenunu O, Botelho RJ, Antonescu CN, Karshafian R. AMPK is required for recovery from metabolic stress induced by ultrasound microbubble treatment. Iscience. 26: 105883. PMID 36685038 DOI: 10.1016/j.isci.2022.105883  0.627
2022 Saffi GT, Wang CA, Mangialardi EM, Vacher J, Botelho RJ, Salmena L. Inhibition of lipid kinase PIKfyve reveals a role for phosphatase Inpp4b in the regulation of PI(3)P-mediated lysosome dynamics through VPS34 activity. The Journal of Biological Chemistry. 102187. PMID 35760104 DOI: 10.1016/j.jbc.2022.102187  0.355
2022 Cabral-Dias R, Lucarelli S, Zak K, Rahmani S, Judge G, Abousawan J, DiGiovanni LF, Vural D, Anderson KE, Sugiyama MG, Genc G, Hong W, Botelho RJ, Fairn GD, Kim PK, et al. Fyn and TOM1L1 are recruited to clathrin-coated pits and regulate Akt signaling. The Journal of Cell Biology. 221. PMID 35238864 DOI: 10.1083/jcb.201808181  0.741
2021 Sugiyama MG, Cui H, Redka DS, Karimzadeh M, Rujas E, Maan H, Hayat S, Cheung K, Misra R, McPhee JB, Viirre RD, Haller A, Botelho RJ, Karshafian R, Sabatinos SA, et al. Multiscale interactome analysis coupled with off-target drug predictions reveals drug repurposing candidates for human coronavirus disease. Scientific Reports. 11: 23315. PMID 34857794 DOI: 10.1038/s41598-021-02432-7  0.691
2021 Fountain A, Inpanathan S, Alves P, Verdawala MB, Botelho RJ. Phagosome maturation in macrophages: Eat, digest, adapt, and repeat. Advances in Biological Regulation. 82: 100832. PMID 34717137 DOI: 10.1016/j.jbior.2021.100832  0.642
2021 Cabral-Dias R, Awadeh Y, Botelho RJ, Antonescu CN. Detection of Plasma Membrane Phosphoinositide Dynamics Using Genetically Encoded Fluorescent Protein Probes. Methods in Molecular Biology (Clifton, N.J.). 2251: 73-89. PMID 33481232 DOI: 10.1007/978-1-0716-1142-5_5  0.686
2020 Botelho R, Fountain A, Lancaster C, Terebiznik M. Clathrin‐mediated phagosome resolution regenerates lysosomes and maintains degradative capacity of macrophages after phagocytosis The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.03528  0.306
2019 Hipolito VEB, Diaz JA, Tandoc KV, Oertlin C, Ristau J, Chauhan N, Saric A, Mclaughlan S, Larsson O, Topisirovic I, Botelho RJ. Enhanced translation expands the endo-lysosome size and promotes antigen presentation during phagocyte activation. Plos Biology. 17: e3000535. PMID 31800587 DOI: 10.1371/Journal.Pbio.3000535  0.432
2019 Yordanov TE, Hipolito VEB, Liebscher G, Vogel GF, Stasyk T, Herrmann C, Geley S, Teis D, Botelho RJ, Hess MW, Huber LA. BORC regulates late endosomal/lysosomal size through PIKfyve-dependent phosphatidylinositol-3,5-bisphosphate. Traffic (Copenhagen, Denmark). PMID 31314175 DOI: 10.1111/Tra.12679  0.389
2019 Inpanathan S, Botelho RJ. The Lysosome Signaling Platform: Adapting With the Times. Frontiers in Cell and Developmental Biology. 7: 113. PMID 31281815 DOI: 10.3389/Fcell.2019.00113  0.452
2019 Saffi GT, Botelho RJ. Lysosome Fission: Planning for an Exit. Trends in Cell Biology. PMID 31171420 DOI: 10.1016/J.Tcb.2019.05.003  0.418
2018 Genc GE, Hipolito VEB, Botelho RJ, Gumuslu S. Lysophosphatidic acid represses autophagy in prostate carcinoma cells. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. PMID 30403494 DOI: 10.1139/Bcb-2018-0164  0.363
2018 Chintaluri K, Goulden BD, Celmenza C, Saffi G, Miraglia E, Hammond GRV, Botelho RJ. The PH domain from the Toxoplasma gondii PH-containing protein-1 (TgPH1) serves as an ectopic reporter of phosphatidylinositol 3-phosphate in mammalian cells. Plos One. 13: e0198454. PMID 29870544 DOI: 10.1371/Journal.Pone.0198454  0.383
2018 Lancaster CE, Ho CY, Hipolito VEB, Botelho RJ, Terebiznik MR. Phagocytosis: What's on the menu? Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. PMID 29791809 DOI: 10.1139/Bcb-2018-0008  0.341
2018 Choy CH, Saffi G, Gray MA, Wallace C, Dayam RM, Ou ZA, Lenk G, Puertollano R, Watkins SC, Botelho RJ. Lysosome enlargement during inhibition of the lipid kinase PIKfyve proceeds through lysosome coalescence. Journal of Cell Science. PMID 29661845 DOI: 10.1242/Jcs.213587  0.424
2018 Hipolito VEB, Ospina-Escobar E, Botelho RJ. Lysosome remodelling and adaptation during phagocyte activation. Cellular Microbiology. PMID 29349904 DOI: 10.1111/Cmi.12824  0.427
2017 Naufer A, Hipolito VEB, Ganesan S, Prashar A, Zaremberg V, Botelho RJ, Terebiznik MR. pH of endophagosomes controls association of their membranes with Vps34 and PtdIns(3)P levels. The Journal of Cell Biology. PMID 29089378 DOI: 10.1083/Jcb.201702179  0.384
2017 Choy CH, Han BK, Botelho RJ. Phosphoinositide Diversity, Distribution, and Effector Function: Stepping Out of the Box. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. PMID 28977683 DOI: 10.1002/Bies.201700121  0.413
2017 Santos RCD, Bautista S, Lucarelli S, Bone LN, Dayam RM, Abousawan J, Botelho RJ, Antonescu CN. Selective regulation of clathrin-mediated EGFR signaling and endocytosis by phospholipase C and calcium. Molecular Biology of the Cell. PMID 28814502 DOI: 10.1091/Mbc.E16-12-0871  0.686
2017 Dayam RM, Sun CX, Choy CH, Mancuso G, Glogauer M, Botelho RJ. The Lipid Kinase PIKfyve Coordinates the Neutrophil Immune Response through the Activation of the Rac GTPase. Journal of Immunology (Baltimore, Md. : 1950). PMID 28779020 DOI: 10.4049/Jimmunol.1601466  0.463
2017 Liu AP, Botelho RJ, Antonescu CN. The big and intricate dreams of little organselles: Embracing complexity in the study of membrane traffic. Traffic (Copenhagen, Denmark). PMID 28574194 DOI: 10.1111/Tra.12497  0.694
2017 Bone LN, Dayam RM, Lee M, Kono N, Fairn GD, Arai H, Botelho RJ, Antonescu CN. The acyltransferase LYCAT controls specific phosphoinositides and related membrane traffic. Molecular Biology of the Cell. 28: 161-172. PMID 28035047 DOI: 10.1091/Mbc.E16-09-0668  0.765
2017 Dayam RM, Botelho RJ. Quantitative Immunofluorescence to Study Phagosome Maturation. Methods in Molecular Biology (Clifton, N.J.). 1519: 113-123. PMID 27815876 DOI: 10.1007/978-1-4939-6581-6_8  0.425
2017 Choy CH, Botelho RJ. Quantifying Phagocytosis by Immunofluorescence and Microscopy. Methods in Molecular Biology (Clifton, N.J.). 1519: 43-53. PMID 27815872 DOI: 10.1007/978-1-4939-6581-6_4  0.464
2017 Gray M, Botelho RJ. Phagocytosis: Hungry, Hungry Cells. Methods in Molecular Biology (Clifton, N.J.). 1519: 1-16. PMID 27815869 DOI: 10.1007/978-1-4939-6581-6_1  0.499
2016 Gray MA, Choy CH, Dayam RM, Ospina-Escobar E, Somerville A, Xiao X, Ferguson SM, Botelho RJ. Phagocytosis Enhances Lysosomal and Bactericidal Properties by Activating the Transcription Factor TFEB. Current Biology : Cb. PMID 27397893 DOI: 10.1016/J.Cub.2016.05.070  0.418
2016 Ho CY, Choy CH, Botelho RJ. Radiolabeling and Quantification of Cellular Levels of Phosphoinositides by High Performance Liquid Chromatography-coupled Flow Scintillation. Journal of Visualized Experiments : Jove. PMID 26780479 DOI: 10.3791/53529  0.356
2015 Saric A, Hipolito VE, Kay JG, Canton J, Antonescu CN, Botelho RJ. mTOR controls lysosome tubulation and antigen presentation in macrophages and dendritic cells. Molecular Biology of the Cell. PMID 26582390 DOI: 10.1091/Mbc.E15-05-0272  0.689
2015 Dayam RM, Saric A, Shilliday RE, Botelho RJ. The Phosphoinositide-Gated Lysosomal Ca(2+) Channel, TRPML1, Is Required for Phagosome Maturation. Traffic (Copenhagen, Denmark). 16: 1010-26. PMID 26010303 DOI: 10.1111/Tra.12303  0.385
2015 Ho CY, Choy CH, Wattson CA, Johnson DE, Botelho RJ. The Fab1/PIKfyve phosphoinositide phosphate kinase is not necessary to maintain the pH of lysosomes and of the yeast vacuole. The Journal of Biological Chemistry. 290: 9919-28. PMID 25713145 DOI: 10.1074/Jbc.M114.613984  0.301
2014 Kim GH, Dayam RM, Prashar A, Terebiznik M, Botelho RJ. PIKfyve inhibition interferes with phagosome and endosome maturation in macrophages. Traffic (Copenhagen, Denmark). 15: 1143-63. PMID 25041080 DOI: 10.1111/Tra.12199  0.517
2014 Botelho RJ. BioEssays in phosphoinositides: a special collection. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 36: 123-4. PMID 24424724 DOI: 10.1002/Bies.201300179  0.433
2013 Alghamdi TA, Ho CY, Mrakovic A, Taylor D, Mao D, Botelho RJ. Vac14 protein multimerization is a prerequisite step for Fab1 protein complex assembly and function. The Journal of Biological Chemistry. 288: 9363-72. PMID 23389034 DOI: 10.1074/Jbc.M113.453712  0.376
2012 Mrakovic A, Kay JG, Furuya W, Brumell JH, Botelho RJ. Rab7 and Arl8 GTPases are necessary for lysosome tubulation in macrophages. Traffic (Copenhagen, Denmark). 13: 1667-79. PMID 22909026 DOI: 10.1111/Tra.12003  0.633
2012 Ho CY, Alghamdi TA, Botelho RJ. Phosphatidylinositol-3,5-bisphosphate: no longer the poor PIP2. Traffic (Copenhagen, Denmark). 13: 1-8. PMID 21736686 DOI: 10.1111/J.1600-0854.2011.01246.X  0.407
2011 Botelho RJ, Grinstein S. Phagocytosis. Current Biology : Cb. 21: R533-8. PMID 21783028 DOI: 10.1016/j.cub.2011.05.053  0.433
2009 Fairn GD, Ogata K, Botelho RJ, Stahl PD, Anderson RA, De Camilli P, Meyer T, Wodak S, Grinstein S. An electrostatic switch displaces phosphatidylinositol phosphate kinases from the membrane during phagocytosis. The Journal of Cell Biology. 187: 701-14. PMID 19951917 DOI: 10.1085/Jgp1351Oia1  0.717
2009 Botelho RJ. Changing phosphoinositides "on the fly": how trafficking vesicles avoid an identity crisis. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 31: 1127-36. PMID 19708025 DOI: 10.1002/Bies.200900060  0.466
2009 Botelho RJ, Harrison RE, Stone JC, Hancock JF, Philips MR, Jongstra-Bilen J, Mason D, Plumb J, Gold MR, Grinstein S. Localized diacylglycerol-dependent stimulation of Ras and Rap1 during phagocytosis. The Journal of Biological Chemistry. 284: 28522-32. PMID 19700408 DOI: 10.1074/Jbc.M109.009514  0.498
2008 Botelho RJ, Efe JA, Teis D, Emr SD. Assembly of a Fab1 phosphoinositide kinase signaling complex requires the Fig4 phosphoinositide phosphatase. Molecular Biology of the Cell. 19: 4273-86. PMID 18653468 DOI: 10.1091/Mbc.E08-04-0405  0.4
2007 Efe JA, Botelho RJ, Emr SD. Atg18 regulates organelle morphology and Fab1 kinase activity independent of its membrane recruitment by phosphatidylinositol 3,5-bisphosphate. Molecular Biology of the Cell. 18: 4232-44. PMID 17699591 DOI: 10.1091/Mbc.E07-04-0301  0.476
2005 Efe JA, Botelho RJ, Emr SD. The Fab1 phosphatidylinositol kinase pathway in the regulation of vacuole morphology. Current Opinion in Cell Biology. 17: 402-8. PMID 15975782 DOI: 10.1016/J.Ceb.2005.06.002  0.476
2005 Tse SM, Mason D, Botelho RJ, Chiu B, Reyland M, Hanada K, Inman RD, Grinstein S. Accumulation of diacylglycerol in the Chlamydia inclusion vacuole: possible role in the inhibition of host cell apoptosis. The Journal of Biological Chemistry. 280: 25210-5. PMID 15863503 DOI: 10.1074/Jbc.M501980200  0.532
2005 Scott CC, Dobson W, Botelho RJ, Coady-Osberg N, Chavrier P, Knecht DA, Heath C, Stahl P, Grinstein S. Phosphatidylinositol-4,5-bisphosphate hydrolysis directs actin remodeling during phagocytosis. The Journal of Cell Biology. 169: 139-49. PMID 15809313 DOI: 10.1083/Jcb.200412162  0.532
2004 Botelho RJ, Scott CC, Grinstein S. Phosphoinositide involvement in phagocytosis and phagosome maturation. Current Topics in Microbiology and Immunology. 282: 1-30. PMID 14594212 DOI: 10.1007/978-3-642-18805-3_1  0.55
2003 Scott CC, Botelho RJ, Grinstein S. Phagosome maturation: a few bugs in the system. The Journal of Membrane Biology. 193: 137-52. PMID 12962275 DOI: 10.1007/S00232-002-2008-2  0.57
2003 Gu H, Botelho RJ, Yu M, Grinstein S, Neel BG. Critical role for scaffolding adapter Gab2 in FcγR-mediated phagocytosis Journal of Cell Biology. 161: 1151-1161. PMID 12821647 DOI: 10.1083/Jcb.200212158  0.588
2003 Dombrosky-Ferlan P, Grishin A, Botelho RJ, Sampson M, Wang L, Rudert WA, Grinstein S, Corey SJ. Felic (CIP4b), a novel binding partner with the Src kinase Lyn and Cdc42, localizes to the phagocytic cup. Blood. 101: 2804-9. PMID 12456510 DOI: 10.1182/Blood-2002-03-0851  0.534
2002 Botelho RJ, Tapper H, Furuya W, Mojdami D, Grinstein S. Fc gamma R-mediated phagocytosis stimulates localized pinocytosis in human neutrophils. Journal of Immunology (Baltimore, Md. : 1950). 169: 4423-9. PMID 12370376 DOI: 10.4049/Jimmunol.169.8.4423  0.571
2002 Vieira OV, Botelho RJ, Grinstein S. Phagosome maturation: aging gracefully. The Biochemical Journal. 366: 689-704. PMID 12061891 DOI: 10.1042/Bj20020691  0.566
2001 Vieira OV, Botelho RJ, Rameh L, Brachmann SM, Matsuo T, Davidson HW, Schreiber A, Backer JM, Cantley LC, Grinstein S. Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation. The Journal of Cell Biology. 155: 19-25. PMID 11581283 DOI: 10.1083/Jcb.200107069  0.544
2001 Hackam DJ, Botelho RJ, Sjolin C, Rotstein OD, Robinson JM, Schreiber AD, Grinstein S. Indirect role for COPI in the completion of FCgamma receptor-mediated phagocytosis. The Journal of Biological Chemistry. 276: 18200-8. PMID 11279223 DOI: 10.1074/jbc.M102009200  0.555
2000 Botelho RJ, Teruel M, Dierckman R, Anderson R, Wells A, York JD, Meyer T, Grinstein S. Localized biphasic changes in phosphatidylinositol-4,5-bisphosphate at sites of phagocytosis. The Journal of Cell Biology. 151: 1353-68. PMID 11134066 DOI: 10.1083/Jcb.151.7.1353  0.585
2000 Botelho RJ, Hackam DJ, Schreiber AD, Grinstein S. Role of COPI in phagosome maturation. The Journal of Biological Chemistry. 275: 15717-27. PMID 10748188 DOI: 10.1074/Jbc.M910068199  0.593
1999 Downey GP, Botelho RJ, Butler JR, Moltyaner Y, Chien P, Schreiber AD, Grinstein S. Phagosomal maturation, acidification, and inhibition of bacterial growth in nonphagocytic cells transfected with FcgammaRIIA receptors. The Journal of Biological Chemistry. 274: 28436-44. PMID 10497205 DOI: 10.1074/Jbc.274.40.28436  0.574
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