Year |
Citation |
Score |
2019 |
Wang Y, Shen W, Liang XH, Crooke ST. Phosphorothioate Antisense Oligonucleotides Bind P-Body Proteins and Mediate P-Body Assembly. Nucleic Acid Therapeutics. PMID 31429620 DOI: 10.1089/Nat.2019.0806 |
0.307 |
|
2019 |
Shen W, De Hoyos CL, Migawa MT, Vickers TA, Sun H, Low A, Bell TA, Rahdar M, Mukhopadhyay S, Hart CE, Bell M, Riney S, Murray SF, Greenlee S, Crooke RM, et al. Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index. Nature Biotechnology. PMID 31036929 DOI: 10.1038/S41587-019-0106-2 |
0.344 |
|
2019 |
Migawa MT, Shen W, Wan WB, Vasquez G, Oestergaard ME, Low A, De Hoyos CL, Gupta R, Murray S, Tanowitz M, Bell M, Nichols JG, Gaus H, Liang XH, Swayze EE, et al. Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins. Nucleic Acids Research. PMID 31034558 DOI: 10.1093/Nar/Gkz247 |
0.353 |
|
2018 |
Shen W, De Hoyos CL, Sun H, Vickers TA, Liang XH, Crooke ST. Acute hepatotoxicity of 2' fluoro-modified 5-10-5 gapmer phosphorothioate oligonucleotides in mice correlates with intracellular protein binding and the loss of DBHS proteins. Nucleic Acids Research. PMID 29390093 DOI: 10.1093/Nar/Gky060 |
0.319 |
|
2017 |
Bailey JK, Shen W, Liang XH, Crooke ST. Nucleic acid binding proteins affect the subcellular distribution of phosphorothioate antisense oligonucleotides. Nucleic Acids Research. PMID 28977508 DOI: 10.1093/Nar/Gkx709 |
0.345 |
|
2017 |
Liang XH, Sun H, Shen W, Wang S, Yao J, Migawa MT, Bui HH, Damle SS, Riney S, Graham MJ, Crooke RM, Crooke ST. Antisense oligonucleotides targeting translation inhibitory elements in 5' UTRs can selectively increase protein levels. Nucleic Acids Research. 45: 9528-9546. PMID 28934489 DOI: 10.1093/Nar/Gkx632 |
0.327 |
|
2017 |
Liang XH, Shen W, Crooke ST. Specific Increase of Protein Levels by Enhancing Translation Using Antisense Oligonucleotides Targeting Upstream Open Frames. Advances in Experimental Medicine and Biology. 983: 129-146. PMID 28639196 DOI: 10.1007/978-981-10-4310-9_9 |
0.336 |
|
2017 |
Crooke ST, Wang S, Vickers TA, Shen W, Liang XH. Cellular uptake and trafficking of antisense oligonucleotides. Nature Biotechnology. PMID 28244996 DOI: 10.1038/Nbt.3779 |
0.372 |
|
2016 |
Liang XH, Shen W, Sun H, Migawa MT, Vickers TA, Crooke ST. Translation efficiency of mRNAs is increased by antisense oligonucleotides targeting upstream open reading frames. Nature Biotechnology. PMID 27398791 DOI: 10.1038/Nbt.3589 |
0.354 |
|
2016 |
Liang XH, Shen W, Sun H, Kinberger GA, Prakash TP, Nichols JG, Crooke ST. Hsp90 protein interacts with phosphorothioate oligonucleotides containing hydrophobic 2'-modifications and enhances antisense activity. Nucleic Acids Research. PMID 26945041 DOI: 10.1093/Nar/Gkw144 |
0.343 |
|
2015 |
Shen W, Liang XH, Sun H, Crooke ST. 2'-Fluoro-modified phosphorothioate oligonucleotide can cause rapid degradation of P54nrb and PSF. Nucleic Acids Research. 43: 4569-78. PMID 25855809 DOI: 10.1093/Nar/Gkv298 |
0.3 |
|
2015 |
Liang XH, Sun H, Shen W, Crooke ST. Identification and characterization of intracellular proteins that bind oligonucleotides with phosphorothioate linkages. Nucleic Acids Research. 43: 2927-45. PMID 25712094 DOI: 10.1093/Nar/Gkv143 |
0.356 |
|
2014 |
Shen W, Liang XH, Crooke ST. Phosphorothioate oligonucleotides can displace NEAT1 RNA and form nuclear paraspeckle-like structures. Nucleic Acids Research. 42: 8648-62. PMID 25013176 DOI: 10.1093/Nar/Gku579 |
0.312 |
|
2014 |
Liang XH, Shen W, Sun H, Prakash TP, Crooke ST. TCP1 complex proteins interact with phosphorothioate oligonucleotides and can co-localize in oligonucleotide-induced nuclear bodies in mammalian cells. Nucleic Acids Research. 42: 7819-32. PMID 24861627 DOI: 10.1093/Nar/Gku484 |
0.328 |
|
2011 |
Shen W, Gorelick RJ, Bambara RA. HIV-1 nucleocapsid protein increases strand transfer recombination by promoting dimeric G-quartet formation. The Journal of Biological Chemistry. 286: 29838-47. PMID 21737842 DOI: 10.1074/Jbc.M111.262352 |
0.505 |
|
2009 |
Shen W, Gao L, Balakrishnan M, Bambara RA. A recombination hot spot in HIV-1 contains guanosine runs that can form a G-quartet structure and promote strand transfer in vitro. The Journal of Biological Chemistry. 284: 33883-93. PMID 19822521 DOI: 10.1074/Jbc.M109.055368 |
0.513 |
|
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