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Silvia L. Delker, Ph.D. - Publications

Affiliations: 
2009 Biological Sciences - Ph.D. University of California, Irvine, Irvine, CA 
Area:
Molecular Biology
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15 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Basak S, Li Y, Tao S, Daryaee F, Merino J, Gu C, Delker SL, Phan JN, Edwards TE, Walker SG, Tonge PJ. Structure-Kinetic Relationship Studies for the Development of Long Residence Time LpxC Inhibitors. Journal of Medicinal Chemistry. PMID 36037447 DOI: 10.1021/acs.jmedchem.2c00974  0.332
2017 Riggs JR, Nagy M, Elsner J, Erdman P, Cashion D, Robinson D, Harris R, Huang D, Tehrani L, Deyanat-Yazdi G, Narla RK, Peng X, Tran T, Barnes L, Miller T, ... ... Delker SL, et al. The discovery of a dual TTK protein kinase/ CDC2-like kinase (CLK2) inhibitor for the treatment of triple negative breast cancer initiated from a phenotypic screen. Journal of Medicinal Chemistry. PMID 28991472 DOI: 10.1021/Acs.Jmedchem.7B01223  0.387
2014 Chamberlain P, Delker S, Pagarigan B, Mahmoudi A, Jackson P, Abbasian M, Muir J, Raheja N, Cathers B. Crystal structures of PRK1 in complex with the clinical compounds lestaurtinib and tofacitinib reveal ligand induced conformational changes. Plos One. 9: e103638. PMID 25111382 DOI: 10.1371/Journal.Pone.0103638  0.45
2014 Chamberlain PP, Lopez-Girona A, Miller K, Carmel G, Pagarigan B, Chie-Leon B, Rychak E, Corral LG, Ren YJ, Wang M, Riley M, Delker SL, Ito T, Ando H, Mori T, et al. Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs. Nature Structural & Molecular Biology. 21: 803-9. PMID 25108355 DOI: 10.1038/Nsmb.2874  0.373
2014 Li H, Jamal J, Delker S, Plaza C, Ji H, Jing Q, Huang H, Kang S, Silverman RB, Poulos TL. The mobility of a conserved tyrosine residue controls isoform-dependent enzyme-inhibitor interactions in nitric oxide synthases. Biochemistry. 53: 5272-9. PMID 25089924 DOI: 10.1021/Bi500561H  0.654
2014 Delker S, Robinson D, Bahmanyar S, Pagarigan B, Fang W, Abbasian M, Mahmoudi A, Cashion D, Cathers B, Chamberlain P. Inhibitor Binding Mode Differences Within the AGC Subfamily Acta Crystallographica Section a Foundations and Advances. 70: C1640-C1640. DOI: 10.1107/S2053273314083594  0.491
2013 Li H, Xue F, Kraus JM, Ji H, Labby KJ, Mataka J, Delker SL, Martásek P, Roman LJ, Poulos TL, Silverman RB. Cyclopropyl- and methyl-containing inhibitors of neuronal nitric oxide synthase Bioorganic and Medicinal Chemistry. 21: 1333-1343. PMID 23352768 DOI: 10.1016/J.Bmc.2012.12.019  0.682
2012 Plantevin Krenitsky V, Nadolny L, Delgado M, Ayala L, Clareen SS, Hilgraf R, Albers R, Hegde S, D'Sidocky N, Sapienza J, Wright J, McCarrick M, Bahmanyar S, Chamberlain P, Delker SL, et al. Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor. Bioorganic & Medicinal Chemistry Letters. 22: 1433-8. PMID 22244937 DOI: 10.1016/J.Bmcl.2011.12.027  0.461
2011 Xue F, Kraus JM, Labby KJ, Ji H, Mataka J, Xia G, Li H, Delker SL, Roman LJ, Martásek P, Poulos TL, Silverman RB. Improved synthesis of chiral pyrrolidine inhibitors and their binding properties to neuronal nitric oxide synthase Journal of Medicinal Chemistry. 54: 6399-6403. PMID 21809851 DOI: 10.1021/Jm200411J  0.672
2011 Xue F, Fang J, Delker SL, Li H, Martásek P, Roman LJ, Poulos TL, Silverman RB. Symmetric double-headed aminopyridines, a novel strategy for potent and membrane-permeable inhibitors of neuronal nitric oxide synthase Journal of Medicinal Chemistry. 54: 2039-2048. PMID 21410186 DOI: 10.1021/Jm101071N  0.702
2010 Delker SL, Xue F, Li H, Jamal J, Silverman RB, Poulos TL. Role of zinc in isoform-selective inhibitor binding to neuronal nitric oxide synthase Biochemistry. 49: 10803-10810. PMID 21138269 DOI: 10.1021/Bi1013479  0.691
2010 Ji H, Delker SL, Li H, Martásek P, Roman LJ, Poulos TL, Silverman RB. Exploration of the active site of neuronal nitric oxide synthase by the design and synthesis of pyrrolidinomethyl 2-aminopyridine derivatives Journal of Medicinal Chemistry. 53: 7804-7824. PMID 20958055 DOI: 10.1021/Jm100947X  0.632
2010 Xue F, Li H, Delker SL, Fang J, Martásek P, Roman LJ, Poulos TL, Silverman RB. Potent, highly selective, and orally bioavailable gem-difluorinated monocationic inhibitors of neuronal nitric oxide synthase Journal of the American Chemical Society. 132: 14229-14238. PMID 20843082 DOI: 10.1021/Ja106175Q  0.631
2010 Delker SL, Ji H, Li H, Jamal J, Fang J, Xue F, Silverman RB, Poulos TL. Unexpected binding modes of nitric oxide synthase inhibitors effective in the prevention of a cerebral palsy phenotype in an animal model Journal of the American Chemical Society. 132: 5437-5442. PMID 20337441 DOI: 10.1021/Ja910228A  0.693
2010 Delker SL, Ji H, Li H, Jamal J, Fang J, Xue F, Silverman RB, Poulos TL. Unexpected Binding Modes of Nitric Oxide Synthase Inhibitors Effective in the Prevention of a Cerebral Palsy Phenotype in an Animal Model Journal of the American Chemical Society. 132: 14688-14688. DOI: 10.1021/Ja107808U  0.606
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