| Year |
Citation |
Score |
| 2023 |
Magurany KA, Chang X, Clewell R, Coecke S, Haugabrooks E, Marty S. A Pragmatic Framework for the Application of New Approach Methodologies in One Health Toxicological Risk Assessment. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 36782355 DOI: 10.1093/toxsci/kfad012 |
0.311 |
|
| 2022 |
Stefanowicz AJ, Recio L, Black MB, Beames T, Andersen ME, Stern RA, Clewell RA, McMullen PD, Hartman JK, Ranade A. Comparison of Rat Hepatocyte 2D-Monocultures and Hepatocytes Non-Parenchymal Cell Co-Cultures for Assessing Chemical Toxicity. International Journal of Toxicology. 10915818221139471. PMID 36523256 DOI: 10.1177/10915818221139471 |
0.483 |
|
| 2022 |
Nicolas CI, Linakis MW, Minto MS, Mansouri K, Clewell RA, Yoon M, Wambaugh JF, Patlewicz G, McMullen PD, Andersen ME, Clewell Iii HJ. Estimating provisional margins of exposure for data-poor chemicals using high-throughput computational methods. Frontiers in Pharmacology. 13: 980747. PMID 36278238 DOI: 10.3389/fphar.2022.980747 |
0.482 |
|
| 2022 |
Clewell RA, Clewell HJ, Linakis MW, Easley CA, Langmo JN, Salley J, Gentry R, Rücker T. An in vitro approach to determine the human relevance of anti-spermatogenic effects of 4-methylmorpholine 4-oxide, monohydrate (NMMO) in rat reproductive toxicity studies. Toxicology in Vitro : An International Journal Published in Association With Bibra. 82: 105365. PMID 35470028 DOI: 10.1016/j.tiv.2022.105365 |
0.323 |
|
| 2021 |
Efremenko A, Balbuena P, Clewell RA, Black M, Pluta L, Andersen ME, Gentry PR, Yager JW, Clewell HJ. Time-dependent genomic response in primary human uroepithelial cells exposed to arsenite for up to 60 days. Toxicology. 461: 152893. PMID 34425169 DOI: 10.1016/j.tox.2021.152893 |
0.466 |
|
| 2020 |
Campbell JL, Otter R, Anderson WA, Longnecker MP, Clewell RA, North C, Clewell HJ. Development of a physiologically based pharmacokinetic model of diisononyl phthalate (DiNP) in pregnant rat and human. Journal of Toxicology and Environmental Health. Part A. 1-18. PMID 32757748 DOI: 10.1080/15287394.2020.1798831 |
0.408 |
|
| 2020 |
Clewell RA, Leonard JA, Nicolas CI, Campbell J, Yoon M, Efremenko AY, McMullen PD, Andersen ME, Clewell HJ, Phillips KA, Tan YM. Application of a combined aggregate exposure pathway and adverse outcome pathway (AEP-AOP) approach to inform a cumulative risk assessment: A case study with phthalates. Toxicology in Vitro : An International Journal Published in Association With Bibra. 104855. PMID 32278033 DOI: 10.1016/J.Tiv.2020.104855 |
0.575 |
|
| 2020 |
Nicolas CI, Bronson K, Pendse SN, Efremenko A, Fitzpatrick JM, Minto MS, Mansouri K, Yoon M, Phillips MB, Clewell RA, Andersen ME, Clewell HJ, McMullen PD. The TTC Data Mart: an interactive browser for Threshold of Toxicological Concern calculations Computational Toxicology. 15: 100128. DOI: 10.1016/J.Comtox.2020.100128 |
0.337 |
|
| 2019 |
Beames T, Moreau M, Roberts LA, Mansouri K, Haider S, Smeltz M, Nicolas CI, Doheny D, Phillips MB, Yoon M, Becker RA, McMullen PD, Andersen ME, Clewell RA, Hartman JK. The role of fit-for-purpose assays within tiered testing approaches: A case study evaluating prioritized estrogen-active compounds in an in vitro human uterotrophic assay. Toxicology and Applied Pharmacology. 114774. PMID 31783037 DOI: 10.1016/J.Taap.2019.114774 |
0.584 |
|
| 2019 |
Andersen ME, McMullen PD, Phillips MB, Yoon M, Pendse SN, Clewell HJ, Hartman JK, Moreau M, Becker RA, Clewell RA. Developing context appropriate toxicity testing approaches using new alternative methods (NAMs). Altex. 36: 523-534. PMID 31664457 DOI: 10.14573/Altex.1906261 |
0.576 |
|
| 2019 |
McMullen PD, Bhattacharya S, Woods CG, Pendse SN, McBride MT, Soldatow VY, Deisenroth C, LeCluyse EL, Clewell RA, Andersen ME. Identifying qualitative differences in PPARα signaling networks in human and rat hepatocytes and their significance for next generation chemical risk assessment methods. Toxicology in Vitro : An International Journal Published in Association With Bibra. PMID 31628012 DOI: 10.1016/J.Tiv.2019.02.017 |
0.544 |
|
| 2019 |
McMullen PD, Pendse SN, Black MB, Mansouri K, Haider S, Andersen ME, Clewell RA. Addressing systematic inconsistencies between in vitro and in vivo transcriptomic mode of action signatures. Toxicology in Vitro : An International Journal Published in Association With Bibra. PMID 30807807 DOI: 10.1016/J.Tiv.2019.02.014 |
0.569 |
|
| 2019 |
Clewell RA, Thompson CM, Clewell HJ. Dose-dependence of chemical carcinogenicity: Biological mechanisms for thresholds and implications for risk assessment. Chemico-Biological Interactions. PMID 30763550 DOI: 10.1016/J.Cbi.2019.01.025 |
0.411 |
|
| 2019 |
Clewell HH, Gentry PR, Hack CE, Greene T, Clewell RA. An evaluation of the USEPA Proposed Approaches for applying a biologically based dose-response model in a risk assessment for perchlorate in drinking water. Regulatory Toxicology and Pharmacology : Rtp. PMID 30707931 DOI: 10.1016/J.Yrtph.2019.01.028 |
0.38 |
|
| 2018 |
Haider S, Black MB, Parks BB, Foley B, Wetmore BA, Andersen ME, Clewell RA, Mansouri K, McMullen PD. A Qualitative Modeling Approach for Whole Genome Prediction Using High-Throughput Toxicogenomics Data and Pathway-Based Validation. Frontiers in Pharmacology. 9: 1072. PMID 30333746 DOI: 10.3389/Fphar.2018.01072 |
0.522 |
|
| 2018 |
Wetmore BA, Clewell RA, Cholewa B, Parks B, Pendse SN, Black MB, Mansouri K, Haider S, Berg EL, Judson RS, Houck KA, Martin M, Clewell HJ, Andersen ME, Thomas RS, et al. Assessing bioactivity-exposure profiles of fruit and vegetable extracts in the BioMAP profiling system. Toxicology in Vitro : An International Journal Published in Association With Bibra. PMID 30218698 DOI: 10.1016/J.Tiv.2018.09.006 |
0.541 |
|
| 2018 |
Hartman JK, Beames T, Parks B, Doheny D, Song G, Efremenko A, Yoon M, Foley B, Deisenroth C, McMullen PD, Clewell RA. An in vitro approach for prioritization and evaluation of chemical effects on glucocorticoid receptor mediated adipogenesis. Toxicology and Applied Pharmacology. PMID 29782964 DOI: 10.1016/J.Taap.2018.05.016 |
0.384 |
|
| 2018 |
McMullen PD, Andersen ME, Cholewa B, Clewell HJ, Dunnick K, Hartman J, Mansouri K, Minto MS, Nicolas CI, Phillips M, Slattery S, Yoon M, Clewell RA. Evaluating opportunities for advancing the use of alternative methods in risk assessment through the development of fit-for-purpose in vitro assays. Toxicology in Vitro : An International Journal Published in Association With Bibra. PMID 29391263 DOI: 10.1016/J.Tiv.2018.01.027 |
0.576 |
|
| 2017 |
Miller MM, McMullen PD, Andersen ME, Clewell RA. Multiple receptors shape the estrogen response pathway and are critical considerations for the future of in vitro-based risk assessment efforts. Critical Reviews in Toxicology. 1-17. PMID 28675057 DOI: 10.1080/10408444.2017.1289150 |
0.563 |
|
| 2017 |
Sun B, Ross SM, Rowley S, Adeleye Y, Clewell RA. Contribution of ATM and ATR kinase pathways to p53-mediated response in etoposide and methyl methanesulfonate induced DNA damage. Environmental and Molecular Mutagenesis. PMID 28195382 DOI: 10.1002/Em.22070 |
0.344 |
|
| 2017 |
Clewell R, Phillips M, Dunnick K, Balbuena P, Yoon M. Incorporation of human relevant metabolism into fit-for-purpose in vitro assays for safety assessment: Case study with bioactivated mutagens Toxicology Letters. 280: S273. DOI: 10.1016/J.Toxlet.2017.07.963 |
0.352 |
|
| 2016 |
Clewell RA, McMullen PD, Adeleye Y, Carmichael PL, Andersen ME. Pathway Based Toxicology and Fit-for-Purpose Assays. Advances in Experimental Medicine and Biology. 856: 205-230. PMID 27671724 DOI: 10.1007/978-3-319-33826-2_8 |
0.603 |
|
| 2016 |
Foley B, Doheny D, Black M, Pendse SN, Wetmore B, Clewell R, Andersen ME, Deisenroth C. Screening ToxCastTM prioritized chemicals for PPARG function in a human adipose-derived stem cell model of adipogenesis. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 27664422 DOI: 10.1093/Toxsci/Kfw186 |
0.527 |
|
| 2016 |
Miller MM, Alyea RA, LeSommer C, Doheny DL, Rowley SM, Childs KM, Balbuena P, Ross SM, Dong J, Sun B, Andersen MA, Clewell RA. Development of an in vitro assay measuring uterine-specific estrogenic responses for use in chemical safety assessment. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 27503385 DOI: 10.1093/Toxsci/Kfw152 |
0.423 |
|
| 2016 |
Klapacz J, Pottenger LH, Engelward BP, Heinen CD, Johnson GE, Clewell RA, Carmichael PL, Adeleye Y, Andersen ME. Contributions of DNA repair and damage response pathways to the non-linear genotoxic responses of alkylating agents. Mutation Research. Reviews in Mutation Research. 767: 77-91. PMID 27036068 DOI: 10.1016/J.Mrrev.2015.11.001 |
0.544 |
|
| 2016 |
Clewell RA, Andersen ME. Approaches for characterizing threshold dose-response relationships for DNA-damage pathways involved in carcinogenicity in vivo and micronuclei formation in vitro. Mutagenesis. PMID 26846943 DOI: 10.1093/Mutage/Gev078 |
0.555 |
|
| 2016 |
Clewell R, Miller M, Andersen M. Adverse outcome pathway driven development of human cell-based assays sufficient for safety assessment of estrogenic chemicals Toxicology Letters. 258: S142-S143. DOI: 10.1016/J.Toxlet.2016.06.1554 |
0.531 |
|
| 2015 |
Peng H, Wang H, Xue P, Hou Y, Dong J, Zhou T, Qu W, Peng S, Li J, Carmichael PL, Nelson B, Clewell R, Zhang Q, Andersen ME, Pi J. Suppression of NRF2-ARE activity sensitizes chemotherapeutic agent-induced cytotoxicity in human acute monocytic leukemia cells. Toxicology and Applied Pharmacology. PMID 26708503 DOI: 10.1016/J.Taap.2015.12.008 |
0.515 |
|
| 2015 |
Zhang Q, Bhattacharya S, Pi J, Clewell RA, Carmichael PL, Andersen ME. Adaptive Posttranslational Control in Cellular Stress Response Pathways and Its Relationship to Toxicity Testing and Safety Assessment. Toxicological Sciences : An Official Journal of the Society of Toxicology. 147: 302-16. PMID 26408567 DOI: 10.1093/Toxsci/Kfv130 |
0.479 |
|
| 2015 |
Adeleye Y, Andersen M, Clewell R, Davies M, Dent M, Edwards S, Fowler P, Malcomber S, Nicol B, Scott A, Scott S, Sun B, Westmoreland C, White A, Zhang Q, et al. Implementing Toxicity Testing in the 21st Century (TT21C): Making safety decisions using toxicity pathways, and progress in a prototype risk assessment. Toxicology. 332: 102-11. PMID 24582757 DOI: 10.1016/J.Tox.2014.02.007 |
0.608 |
|
| 2015 |
Klapacz J, Pottenger LH, Engelward BP, Heinen CD, Johnson GE, Clewell RA, Carmichael PL, Adeleye Y, Andersen ME. Contributions of DNA repair and damage response pathways to the non-linear genotoxic responses of alkylating agents Mutation Research - Reviews in Mutation Research. DOI: 10.1016/j.mrrev.2015.11.001 |
0.431 |
|
| 2014 |
Clewell RA, Sun B, Adeleye Y, Carmichael P, Efremenko A, McMullen PD, Pendse S, Trask OJ, White A, Andersen ME. Profiling dose-dependent activation of p53-mediated signaling pathways by chemicals with distinct mechanisms of DNA damage. Toxicological Sciences : An Official Journal of the Society of Toxicology. 142: 56-73. PMID 25078064 DOI: 10.1093/Toxsci/Kfu153 |
0.564 |
|
| 2014 |
Gentry PR, Yager JW, Clewell RA, Clewell HJ. Use of mode of action data to inform a dose-response assessment for bladder cancer following exposure to inorganic arsenic. Toxicology in Vitro : An International Journal Published in Association With Bibra. 28: 1196-205. PMID 24937311 DOI: 10.1016/J.Tiv.2014.05.011 |
0.383 |
|
| 2014 |
McMullen PD, Bhattacharya S, Woods CG, Sun B, Yarborough K, Ross SM, Miller ME, McBride MT, LeCluyse EL, Clewell RA, Andersen ME. A map of the PPARα transcription regulatory network for primary human hepatocytes. Chemico-Biological Interactions. 209: 14-24. PMID 24269660 DOI: 10.1016/J.Cbi.2013.11.006 |
0.516 |
|
| 2014 |
Li Z, Sun B, Clewell RA, Adeleye Y, Andersen ME, Zhang Q. Dose-response modeling of etoposide-induced DNA damage response. Toxicological Sciences : An Official Journal of the Society of Toxicology. 137: 371-84. PMID 24241721 DOI: 10.1093/Toxsci/Kft259 |
0.584 |
|
| 2013 |
Lv P, Xue P, Dong J, Peng H, Clewell R, Wang A, Wang Y, Peng S, Qu W, Zhang Q, Andersen ME, Pi J. Keap1 silencing boosts lipopolysaccharide-induced transcription of interleukin 6 via activation of nuclear factor κB in macrophages. Toxicology and Applied Pharmacology. 272: 697-702. PMID 23906629 DOI: 10.1016/J.Taap.2013.07.012 |
0.447 |
|
| 2013 |
Sun B, Ross SM, Trask OJ, Carmichael PL, Dent M, White A, Andersen ME, Clewell RA. Assessing dose-dependent differences in DNA-damage, p53 response and genotoxicity for quercetin and curcumin. Toxicology in Vitro : An International Journal Published in Association With Bibra. 27: 1877-87. PMID 23764886 DOI: 10.1016/J.Tiv.2013.05.015 |
0.561 |
|
| 2013 |
Balbuena P, Campbell J, Clewell HJ, Clewell RA. Evaluation of a predictive in vitro Leydig cell assay for anti-androgenicity of phthalate esters in the rat. Toxicology in Vitro : An International Journal Published in Association With Bibra. 27: 1711-8. PMID 23578968 DOI: 10.1016/J.Tiv.2013.03.015 |
0.361 |
|
| 2013 |
Murk AJ, Rijntjes E, Blaauboer BJ, Clewell R, Crofton KM, Dingemans MM, Furlow JD, Kavlock R, Köhrle J, Opitz R, Traas T, Visser TJ, Xia M, Gutleb AC. Mechanism-based testing strategy using in vitro approaches for identification of thyroid hormone disrupting chemicals. Toxicology in Vitro : An International Journal Published in Association With Bibra. 27: 1320-46. PMID 23453986 DOI: 10.1016/J.Tiv.2013.02.012 |
0.395 |
|
| 2013 |
Clewell RA, Thomas A, Willson G, Creasy DM, Andersen ME. A dose response study to assess effects after dietary administration of diisononyl phthalate (DINP) in gestation and lactation on male rat sexual development. Reproductive Toxicology (Elmsford, N.Y.). 35: 70-80. PMID 22944045 DOI: 10.1016/J.Reprotox.2012.07.008 |
0.517 |
|
| 2013 |
Clewell RA, Sochaski M, Edwards K, Creasy DM, Willson G, Andersen ME. Disposition of diiosononyl phthalate and its effects on sexual development of the male fetus following repeated dosing in pregnant rats. Reproductive Toxicology (Elmsford, N.Y.). 35: 56-69. PMID 22813627 DOI: 10.1016/J.Reprotox.2012.07.001 |
0.516 |
|
| 2012 |
Campbell JL, Clewell RA, Gentry PR, Andersen ME, Clewell HJ. Physiologically based pharmacokinetic/toxicokinetic modeling. Methods in Molecular Biology (Clifton, N.J.). 929: 439-99. PMID 23007440 DOI: 10.1007/978-1-62703-050-2_18 |
0.548 |
|
| 2012 |
Choi K, Joo H, Campbell JL, Clewell RA, Andersen ME, Clewell HJ. In vitro metabolism of di(2-ethylhexyl) phthalate (DEHP) by various tissues and cytochrome P450s of human and rat. Toxicology in Vitro : An International Journal Published in Association With Bibra. 26: 315-22. PMID 22186153 DOI: 10.1016/J.Tiv.2011.12.002 |
0.49 |
|
| 2012 |
Gentry PR, Clewell HJ, Clewell R, Campbell J, Van Landingham C, Shipp AM. Challenges in the application of quantitative approaches in risk assessment: a case study with di-(2-ethylhexyl)phthalate. Critical Reviews in Toxicology. 1-72. PMID 21838516 DOI: 10.3109/10408444.2011.599366 |
0.399 |
|
| 2012 |
Dent M, Adeleye Y, Carmichael P, Clewell R, Davies M, Malcomber S, Scott A, White A, Zhang Q, Andersen M, Ingram J. Making safety decisions based on changes in toxicity pathways: A case study Toxicology Letters. 211: S130. DOI: 10.1016/J.Toxlet.2012.03.477 |
0.47 |
|
| 2011 |
Campbell J, Clewell R, Andersen M, Clewell H. Interpreting biomonitoring data for di-n-butyl and di-(2-ethylhexyl) phthalate metabolites in urine using a physiologically based pharmacokinetic model and reverse dosimetry: Estimation of cumulative in utero exposure Toxicology Letters. 205: S210. DOI: 10.1016/J.Toxlet.2011.05.723 |
0.504 |
|
| 2011 |
Clewell R, Sun B, Ross S, Carmichael P, Andersen M. In vitro evaluation of dose-dependent chemically induced DNA damage and p53 pathway response Toxicology Letters. 205: S79. DOI: 10.1016/J.Toxlet.2011.05.295 |
0.547 |
|
| 2010 |
Clewell RA, Campbell JL, Ross SM, Gaido KW, Clewell HJ, Andersen ME. Assessing the relevance of in vitro measures of phthalate inhibition of steroidogenesis for in vivo response. Toxicology in Vitro : An International Journal Published in Association With Bibra. 24: 327-34. PMID 19699292 DOI: 10.1016/J.Tiv.2009.08.003 |
0.544 |
|
| 2009 |
Clewell RA, Pluta L, Thomas RS, Andersen ME. In utero exposure to chloroquine alters sexual development in the male fetal rat. Toxicology and Applied Pharmacology. 237: 366-74. PMID 19393257 DOI: 10.1016/J.Taap.2009.04.013 |
0.544 |
|
| 2009 |
Clewell RA, Kremer JJ, Williams CC, Campbell JL, Sochaski MA, Andersen ME, Borghoff SJ. Kinetics of selected di-n-butyl phthalate metabolites and fetal testosterone following repeated and single administration in pregnant rats. Toxicology. 255: 80-90. PMID 19010379 DOI: 10.1016/J.Tox.2008.10.010 |
0.545 |
|
| 2008 |
Clewell RA, Kremer JJ, Williams CC, Campbell JL, Andersen ME, Borghoff SJ. Tissue exposures to free and glucuronidated monobutylyphthalate in the pregnant and fetal rat following exposure to di-n-butylphthalate: evaluation with a PBPK model. Toxicological Sciences : An Official Journal of the Society of Toxicology. 103: 241-59. PMID 18344531 DOI: 10.1093/Toxsci/Kfn054 |
0.569 |
|
| 2008 |
Clewell RA, Clewell HJ. Development and specification of physiologically based pharmacokinetic models for use in risk assessment. Regulatory Toxicology and Pharmacology : Rtp. 50: 129-43. PMID 18077066 DOI: 10.1016/J.Yrtph.2007.10.012 |
0.434 |
|
| 2007 |
Clewell RA, Merrill EA, Gearhart JM, Robinson PJ, Sterner TR, Mattie DR, Clewell HJ. Perchlorate and radioiodide kinetics across life stages in the human: using PBPK models to predict dosimetry and thyroid inhibition and sensitive subpopulations based on developmental stage. Journal of Toxicology and Environmental Health. Part A. 70: 408-28. PMID 17454566 DOI: 10.1080/15287390600755216 |
0.396 |
|
| 2005 |
Merrill EA, Clewell RA, Robinson PJ, Jarabek AM, Gearhart JM, Sterner TR, Fisher JW. PBPK model for radioactive iodide and perchlorate kinetics and perchlorate-induced inhibition of iodide uptake in humans. Toxicological Sciences : An Official Journal of the Society of Toxicology. 83: 25-43. PMID 15509666 DOI: 10.1093/Toxsci/Kfi017 |
0.349 |
|
| 2003 |
Clewell RA, Merrill EA, Yu KO, Mahle DA, Sterner TR, Fisher JW, Gearhart JM. Predicting neonatal perchlorate dose and inhibition of iodide uptake in the rat during lactation using physiologically-based pharmacokinetic modeling. Toxicological Sciences : An Official Journal of the Society of Toxicology. 74: 416-36. PMID 12805655 DOI: 10.1093/Toxsci/Kfg147 |
0.353 |
|
| 2003 |
Clewell RA, Merrill EA, Yu KO, Mahle DA, Sterner TR, Mattie DR, Robinson PJ, Fisher JW, Gearhart JM. Predicting fetal perchlorate dose and inhibition of iodide kinetics during gestation: a physiologically-based pharmacokinetic analysis of perchlorate and iodide kinetics in the rat. Toxicological Sciences : An Official Journal of the Society of Toxicology. 73: 235-55. PMID 12700398 DOI: 10.1093/Toxsci/Kfg081 |
0.341 |
|
| 2003 |
Merrill EA, Clewell RA, Gearhart JM, Robinson PJ, Sterner TR, Yu KO, Mattie DR, Fisher JW. PBPK predictions of perchlorate distribution and its effect on thyroid uptake of radioiodide in the male rat. Toxicological Sciences : An Official Journal of the Society of Toxicology. 73: 256-69. PMID 12700397 DOI: 10.1093/Toxsci/Kfg080 |
0.376 |
|
| 2001 |
Clewell RA, Merrill EA, Robinson PJ. The use of physiologically based models to integrate diverse data sets and reduce uncertainty in the prediction of perchlorate and iodide kinetics across life stages and species. Toxicology and Industrial Health. 17: 210-22. PMID 12539865 DOI: 10.1191/0748233701Th108Oa |
0.39 |
|
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