Lawrence M. Sayre, PhD, University of California Berkeley, 1977 - Publications

Affiliations: 
Chemistry, Pathology, Environmental Health Sciences Case Western Reserve University, Cleveland Heights, OH, United States 
Website:
http://www.case.edu/artsci/chem/info/highlights/sayre_memorial.html

119 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Gao D, Sayre LM, Podrez EA. Analysis of relationship between oxidized phospholipid structure and interaction with the class B scavenger receptors. Methods in Molecular Biology (Clifton, N.J.). 1208: 29-48. PMID 25323497 DOI: 10.1007/978-1-4939-1441-8_3  0.332
2013 Perry EA, Castellani RJ, Moreira PI, Nunomura A, Lui Q, Harris PL, Sayre LM, Szweda PA, Szweda LI, Zhu X, Smith MA, Perry G. Neurofilaments are the major neuronal target of hydroxynonenal-mediated protein cross-links. Free Radical Research. 47: 507-10. PMID 23566300 DOI: 10.3109/10715762.2013.794265  0.571
2012 Zhu X, Castellani RJ, Moreira PI, Aliev G, Shenk JC, Siedlak SL, Harris PL, Fujioka H, Sayre LM, Szweda PA, Szweda LI, Smith MA, Perry G. Hydroxynonenal-generated crosslinking fluorophore accumulation in Alzheimer disease reveals a dichotomy of protein turnover. Free Radical Biology & Medicine. 52: 699-704. PMID 22137893 DOI: 10.1016/J.Freeradbiomed.2011.11.004  0.6
2011 Shibata T, Shimozu Y, Wakita C, Shibata N, Kobayashi M, Machida S, Kato R, Itabe H, Zhu X, Sayre LM, Uchida K. Lipid peroxidation modification of protein generates Nepsilon-(4-oxononanoyl)lysine as a pro-inflammatory ligand. The Journal of Biological Chemistry. 286: 19943-57. PMID 21471194 DOI: 10.1074/Jbc.M110.187047  0.361
2011 Tang X, Sayre LM, Tochtrop GP. A mass spectrometric analysis of 4-hydroxy-2-(E)-nonenal modification of cytochrome c. Journal of Mass Spectrometry : Jms. 46: 290-7. PMID 21394845 DOI: 10.1002/Jms.1890  0.33
2011 Ernberg K, Zhong B, Ko K, Miller L, Nguyen YH, Sayre LM, Guss JM, Lee I. Structural and enzyme activity studies demonstrate that aryl substituted 2,3-butadienamine analogs inactivate Arthrobacter globiformis amine oxidase (AGAO) by chemical derivatization of the 2,4,5-trihydroxyphenylalanine quinone (TPQ) cofactor. Biochimica Et Biophysica Acta. 1814: 638-46. PMID 21215824 DOI: 10.1016/J.Bbapap.2010.12.016  0.344
2011 Liu Y, Zhang W, Sayre LM. An alternative total synthesis of pentosidine Journal of Heterocyclic Chemistry. 48: 426-433. DOI: 10.1002/Jhet.611  0.642
2010 Chakrabarti E, Ghosh S, Sadhukhan S, Sayre L, Tochtrop GP, Smith JD. Synthesis and biological evaluation of analogues of a novel inhibitor of beta-amyloid secretion. Journal of Medicinal Chemistry. 53: 5302-19. PMID 20568779 DOI: 10.1021/Jm100308G  0.309
2010 Zhu X, Tang X, Zhang J, Tochtrop GP, Anderson VE, Sayre LM. Mass spectrometric evidence for the existence of distinct modifications of different proteins by 2(E),4(E)-decadienal. Chemical Research in Toxicology. 23: 467-73. PMID 20070074 DOI: 10.1021/Tx900379A  0.303
2010 Moreira PI, Sayre LM, Zhu X, Nunomura A, Smith MA, Perry G. Detection and localization of markers of oxidative stress by in situ methods: application in the study of Alzheimer disease. Methods in Molecular Biology (Clifton, N.J.). 610: 419-34. PMID 20013193 DOI: 10.1007/978-1-60327-029-8_25  0.624
2010 Castellani R, Moreira P, Aliev G, Shenk J, Siedlak S, Harris P, Sayre L, Szweda L, Zhu X, Smith M, Perry G, Szweda P. Hydroxynonenal-Generated Crosslinking Fluorophore and Mitochondria-derived Lipoic Acid Accumulation in Alzheimer Disease Reveal a Dichotomy of Protein Turnover Microscopy and Microanalysis. 16: 1014-1015. DOI: 10.1017/S1431927610059350  0.482
2010 Shenk JC, Smith MA, Castellani RJ, Moreira P, Aliev G, Siedlak SL, Harris PL, Sayre L, Szweda PA, Szweda LI, Perry G. P1-196: Lipid peroxidation markers are associated with granulovacuolar degeneration but not lipofuscin formation Alzheimer's & Dementia. 6: S230-S230. DOI: 10.1016/J.Jalz.2010.05.746  0.489
2010 Liu Y, Zhang W, Sayre LM. A straightforward synthesis of pentosidine framework Journal of Heterocyclic Chemistry. 47: 683-686. DOI: 10.1002/Jhet.374  0.588
2009 Zhang GF, Kombu RS, Kasumov T, Han Y, Sadhukhan S, Zhang J, Sayre LM, Ray D, Gibson KM, Anderson VA, Tochtrop GP, Brunengraber H. Catabolism of 4-hydroxyacids and 4-hydroxynonenal via 4-hydroxy-4-phosphoacyl-CoAs. The Journal of Biological Chemistry. 284: 33521-34. PMID 19759021 DOI: 10.1074/Jbc.M109.055665  0.343
2009 Zhu X, Anderson VE, Sayre LM. Charge-derivatized amino acids facilitate model studies on protein side-chain modifications by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Rapid Communications in Mass Spectrometry : Rcm. 23: 2113-24. PMID 19517464 DOI: 10.1002/Rcm.4116  0.332
2009 Zhu X, Gallogly MM, Mieyal JJ, Anderson VE, Sayre LM. Covalent cross-linking of glutathione and carnosine to proteins by 4-oxo-2-nonenal. Chemical Research in Toxicology. 22: 1050-9. PMID 19480392 DOI: 10.1021/Tx9000144  0.378
2009 Lee HP, Zhu X, Zhu X, Skidmore SC, Perry G, Sayre LM, Smith MA, Lee HG. The essential role of ERK in 4-oxo-2-nonenal-mediated cytotoxicity in SH-SY5Y human neuroblastoma cells. Journal of Neurochemistry. 108: 1434-41. PMID 19183271 DOI: 10.1111/J.1471-4159.2009.05883.X  0.496
2009 Shenk JC, Castellani RJ, Moreira P, Aliev G, Siedlak SL, Harris PL, Sayre L, Szweda PA, Smith MA, Perry G. P2-186: Hydroxynonenal generated crosslinking fluorophores accumulate in Alzheimer's disease Alzheimer's & Dementia. 5: P315-P315. DOI: 10.1016/J.Jalz.2009.04.498  0.529
2008 Ishino K, Shibata T, Ishii T, Liu YT, Toyokuni S, Zhu X, Sayre LM, Uchida K. Protein N-acylation: H2O2-mediated covalent modification of protein by lipid peroxidation-derived saturated aldehydes. Chemical Research in Toxicology. 21: 1261-70. PMID 18512967 DOI: 10.1021/tx800080x  0.317
2008 Ling KQ, Li WS, Sayre LM. Oxidations of N-(3-indoleethyl) cyclic aliphatic amines by horseradish peroxidase: the indole ring binds to the enzyme and mediates electron-transfer amine oxidation. Journal of the American Chemical Society. 130: 933-44. PMID 18163622 DOI: 10.1021/Ja075905S  0.623
2008 Sayre LM, Perry G, Smith MA. Oxidative stress and neurotoxicity. Chemical Research in Toxicology. 21: 172-88. PMID 18052107 DOI: 10.1021/Tx700210J  0.576
2007 Zhu X, Sayre LM. Mass spectrometric evidence for long-lived protein adducts of 4-oxo-2-nonenal. Redox Report : Communications in Free Radical Research. 12: 45-9. PMID 17263908 DOI: 10.1179/135100007X162176  0.377
2007 Yuan Q, Zhu X, Sayre LM. Chemical nature of stochastic generation of protein-based carbonyls: metal-catalyzed oxidation versus modification by products of lipid oxidation. Chemical Research in Toxicology. 20: 129-39. PMID 17226935 DOI: 10.1021/Tx600270F  0.488
2007 Zhang Y, Ran C, Zhou G, Sayre LM. Highly potent 3-pyrroline mechanism-based inhibitors of bovine plasma amine oxidase and mass spectrometric confirmation of cofactor derivatization. Bioorganic & Medicinal Chemistry. 15: 1868-77. PMID 17150363 DOI: 10.1016/J.Bmc.2006.11.025  0.345
2006 Sayre LM, Lin D, Yuan Q, Zhu X, Tang X. Protein adducts generated from products of lipid oxidation: focus on HNE and one. Drug Metabolism Reviews. 38: 651-75. PMID 17145694 DOI: 10.1080/03602530600959508  0.561
2006 Qiao C, Ling KQ, Shepard EM, Dooley DM, Sayre LM. Mechanism-based cofactor derivatization of a copper amine oxidase by a branched primary amine recruits the oxidase activity of the enzyme to turn inactivator into substrate. Journal of the American Chemical Society. 128: 6206-19. PMID 16669691 DOI: 10.1021/Ja058838F  0.543
2006 Puttaiah S, Zhang Y, Pilch HA, Pfahler C, Oya-Ito T, Sayre LM, Nagaraj RH. Detection of dideoxyosone intermediates of glycation using a monoclonal antibody: characterization of major epitope structures. Archives of Biochemistry and Biophysics. 446: 186-96. PMID 16406213 DOI: 10.1016/J.Abb.2005.12.002  0.334
2006 Kim J, Zhang Y, Ran C, Sayre LM. Inactivation of bovine plasma amine oxidase by haloallylamines. Bioorganic & Medicinal Chemistry. 14: 1444-53. PMID 16266805 DOI: 10.1016/J.Bmc.2005.09.065  0.723
2006 Zhao S, Jeon HB, Nadkarni DV, Sayre LM. Acid-catalyzed rearrangement of 1-benzyl-2-methyl-3-piperidone to 1-benzyl-2-acetylpyrrolidine Tetrahedron. 62: 6361-6369. DOI: 10.1016/J.Tet.2006.04.038  0.611
2005 Sayre LM, Moreira PI, Smith MA, Perry G. Metal ions and oxidative protein modification in neurological disease. Annali Dell'Istituto Superiore Di Sanitã . 41: 143-64. PMID 16244388  0.551
2005 Lin D, Lee HG, Liu Q, Perry G, Smith MA, Sayre LM. 4-Oxo-2-nonenal is both more neurotoxic and more protein reactive than 4-hydroxy-2-nonenal. Chemical Research in Toxicology. 18: 1219-31. PMID 16097795 DOI: 10.1021/Tx050080Q  0.587
2005 Ling KQ, Sayre LM. Horseradish peroxidase-mediated aerobic and anaerobic oxidations of 3-alkylindoles. Bioorganic & Medicinal Chemistry. 13: 3543-51. PMID 15848767 DOI: 10.1016/J.Bmc.2005.02.013  0.4
2005 Liu Q, Smith MA, Avilá J, DeBernardis J, Kansal M, Takeda A, Zhu X, Nunomura A, Honda K, Moreira PI, Oliveira CR, Santos MS, Shimohama S, Aliev G, de la Torre J, ... ... Sayre LM, et al. Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations. Free Radical Biology & Medicine. 38: 746-54. PMID 15721985 DOI: 10.1016/J.Freeradbiomed.2004.11.005  0.555
2005 Mandal S, Kazmi NH, Sayre LM. Ligand dependence in the copper-catalyzed oxidation of hydroquinones. Archives of Biochemistry and Biophysics. 435: 21-31. PMID 15680903 DOI: 10.1016/J.Abb.2004.11.025  0.312
2005 Wu T, Ling KQ, Sayre LM, McIntire WS. Inhibition of murine N1-acetylated polyamine oxidase by an acetylenic amine and the allenic amine, MDL 72527. Biochemical and Biophysical Research Communications. 326: 483-90. PMID 15582603 DOI: 10.1016/J.Bbrc.2004.11.054  0.354
2004 Sayre LM, Harris PL, Perry G, Smith MA. In situ localization of nonenzymatic peroxidase-like activity of tissue-bound transition metals. Current Protocols in Toxicology / Editorial Board, Mahin D. Maines (Editor-in-Chief) ... [Et Al.]. Unit17.4. PMID 23045100 DOI: 10.1002/0471140856.Tx1704S20  0.474
2004 Lamplot Z, Sebela M, Malon M, Lenobel R, Lemr K, Havlis J, Pec P, Qiao C, Sayre LM. 1,5-diamino-2-pentyne is both a substrate and inactivator of plant copper amine oxidases. European Journal of Biochemistry / Febs. 271: 4696-708. PMID 15606757 DOI: 10.1111/J.1432-1033.2004.04434.X  0.568
2004 O'Connell KM, Langley DB, Shepard EM, Duff AP, Jeon HB, Sun G, Freeman HC, Guss JM, Sayre LM, Dooley DM. Differential inhibition of six copper amine oxidases by a family of 4-(aryloxy)-2-butynamines: evidence for a new mode of inactivation. Biochemistry. 43: 10965-78. PMID 15323556 DOI: 10.1021/Bi0492004  0.585
2004 Qiao C, Jeon HB, Sayre LM. Selective inhibition of bovine plasma amine oxidase by homopropargylamine, a new inactivator motif. Journal of the American Chemical Society. 126: 8038-45. PMID 15212554 DOI: 10.1021/Ja049568O  0.678
2004 Liu Z, Minkler PE, Lin D, Sayre LM. Derivatization of amino acids with N,N-dimethyl-2,4-dinitro-5-fluorobenzylamine for liquid chromatography/electrospray ionization mass spectrometry. Rapid Communications in Mass Spectrometry : Rcm. 18: 1059-65. PMID 15150828 DOI: 10.1002/Rcm.1443  0.629
2004 Liu Y, Sun G, David A, Sayre LM. Model studies on the metal-catalyzed protein oxidation: structure of a possible His-Lys cross-link. Chemical Research in Toxicology. 17: 110-8. PMID 14727925 DOI: 10.1021/Tx034167S  0.663
2004 Atwood CS, Perry G, Zeng H, Kato Y, Jones WD, Ling KQ, Huang X, Moir RD, Wang D, Sayre LM, Smith MA, Chen SG, Bush AI. Copper mediates dityrosine cross-linking of Alzheimer's amyloid-beta. Biochemistry. 43: 560-8. PMID 14717612 DOI: 10.1021/Bi0358824  0.523
2004 Liu Q, Smith MA, Siedlak SL, Harris PL, Maccioni RB, Sayre LM, Perry G. P3-275 Phosphorylation dependent control of oxidative modification in Alzheimer disease Neurobiology of Aging. 25: S432-S433. DOI: 10.1016/S0197-4580(04)81425-8  0.566
2004 Liu Z, Sayre LM. Synthesis of N,N-dimethyl-2,4-dinitro-5-fluorobenzylamine and its reactions with amino acids and peptides Tetrahedron. 60: 1601-1610. DOI: 10.1016/J.Tet.2003.12.001  0.648
2003 Liu Y, Xu G, Sayre LM. Carnosine inhibits (E)-4-hydroxy-2-nonenal-induced protein cross-linking: structural characterization of carnosine-HNE adducts. Chemical Research in Toxicology. 16: 1589-97. PMID 14680373 DOI: 10.1021/Tx034160A  0.644
2003 Jeon HB, Lee Y, Qiao C, Huang H, Sayre LM. Inhibition of bovine plasma amine oxidase by 1,4-diamino-2-butenes and -2-butynes. Bioorganic & Medicinal Chemistry. 11: 4631-41. PMID 14527560 DOI: 10.1016/S0968-0896(03)00521-2  0.687
2003 Liu Q, Raina AK, Smith MA, Sayre LM, Perry G. Hydroxynonenal, toxic carbonyls, and Alzheimer disease. Molecular Aspects of Medicine. 24: 305-13. PMID 12893008 DOI: 10.1016/S0098-2997(03)00025-6  0.596
2003 Liu Z, Minkler PE, Sayre LM. Mass spectroscopic characterization of protein modification by 4-hydroxy-2-(E)-nonenal and 4-oxo-2-(E)-nonenal. Chemical Research in Toxicology. 16: 901-11. PMID 12870893 DOI: 10.1021/Tx0300030  0.608
2003 Jeon HB, Sayre LM. Highly potent propargylamine and allylamine inhibitors of bovine plasma amine oxidase. Biochemical and Biophysical Research Communications. 304: 788-94. PMID 12727226 DOI: 10.1016/S0006-291X(03)00681-8  0.59
2003 Zhang WH, Liu J, Xu G, Yuan Q, Sayre LM. Model studies on protein side chain modification by 4-oxo-2-nonenal. Chemical Research in Toxicology. 16: 512-23. PMID 12703968 DOI: 10.1021/Tx020105A  0.482
2003 Jeon HB, Sun G, Sayre LM. Inactivation of bovine plasma amine oxidase by 4-aryloxy-2-butynamines and related analogs. Biochimica Et Biophysica Acta. 1647: 343-54. PMID 12686156 DOI: 10.1016/S1570-9639(03)00093-1  0.612
2003 Liu Z, Sayre LM. Model studies on the modification of proteins by lipoxidation-derived 2-hydroxyaldehydes. Chemical Research in Toxicology. 16: 232-41. PMID 12588195 DOI: 10.1021/Tx020095D  0.653
2003 Tessier FJ, Monnier VM, Sayre LM, Kornfield JA. Triosidines: novel Maillard reaction products and cross-links from the reaction of triose sugars with lysine and arginine residues. The Biochemical Journal. 369: 705-19. PMID 12379150 DOI: 10.1042/Bj20020668  0.359
2002 Perry G, Nunomura A, Hirai K, Zhu X, Pérez M, Avila J, Castellani RJ, Atwood CS, Aliev G, Sayre LM, Takeda A, Smith MA. Is oxidative damage the fundamental pathogenic mechanism of Alzheimer's and other neurodegenerative diseases? Free Radical Biology & Medicine. 33: 1475-9. PMID 12446204 DOI: 10.1016/S0891-5849(02)01113-9  0.589
2002 Lee Y, Ling KQ, Lu X, Silverman RB, Shepard EM, Dooley DM, Sayre LM. 3-pyrrolines are mechanism-based inactivators of the quinone-dependent amine oxidases but only substrates of the flavin-dependent amine oxidases. Journal of the American Chemical Society. 124: 12135-43. PMID 12371853 DOI: 10.1021/Ja0205434  0.345
2002 Shepard EM, Smith J, Elmore BO, Kuchar JA, Sayre LM, Dooley DM. Towards the development of selective amine oxidase inhibitors. Mechanism-based inhibition of six copper containing amine oxidases. European Journal of Biochemistry / Febs. 269: 3645-58. PMID 12153561 DOI: 10.1046/J.1432-1033.2002.03035.X  0.365
2002 Perry G, Sayre LM, Atwood CS, Castellani RJ, Cash AD, Rottkamp CA, Smith MA. The role of iron and copper in the aetiology of neurodegenerative disorders: therapeutic implications. Cns Drugs. 16: 339-52. PMID 11994023 DOI: 10.2165/00023210-200216050-00006  0.538
2002 Smith MA, Drew KL, Nunomura A, Takeda A, Hirai K, Zhu X, Atwood CS, Raina AK, Rottkamp CA, Sayre LM, Friedland RP, Perry G. Amyloid-beta, tau alterations and mitochondrial dysfunction in Alzheimer disease: the chickens or the eggs? Neurochemistry International. 40: 527-31. PMID 11850109 DOI: 10.1016/S0197-0186(01)00123-1  0.535
2002 Castellani RJ, Perry G, Siedlak SL, Nunomura A, Shimohama S, Zhang J, Montine T, Sayre LM, Smith MA. Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans. Neuroscience Letters. 319: 25-8. PMID 11814645 DOI: 10.1016/S0304-3940(01)02514-9  0.544
2002 Wataya T, Nunomura A, Smith MA, Siedlak SL, Harris PL, Shimohama S, Szweda LI, Kaminski MA, Avila J, Price DL, Cleveland DW, Sayre LM, Perry G. High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal. The Journal of Biological Chemistry. 277: 4644-8. PMID 11733539 DOI: 10.1074/Jbc.M110913200  0.556
2002 Ling KQ, Ren T, Protasiewicz JD, Sayre LM. Structural correction of the 3-methylindole oxidatively-coupled dimer Tetrahedron Letters. 43: 6903-6905. DOI: 10.1016/S0040-4039(02)01623-4  0.351
2001 Ling KQ, Kim J, Sayre LM. Catalytic turnover of benzylamine by a model for the lysine tyrosylquinone (LTQ) cofactor of lysyl oxidase. Journal of the American Chemical Society. 123: 9606-11. PMID 11572681 DOI: 10.1021/Ja011141J  0.749
2001 Campbell A, Smith MA, Sayre LM, Bondy SC, Perry G. Mechanisms by which metals promote events connected to neurodegenerative diseases. Brain Research Bulletin. 55: 125-32. PMID 11470308 DOI: 10.1016/S0361-9230(01)00455-5  0.516
2001 Castellani RJ, Harris PL, Sayre LM, Fujii J, Taniguchi N, Vitek MP, Founds H, Atwood CS, Perry G, Smith MA. Active glycation in neurofibrillary pathology of Alzheimer disease: N(epsilon)-(carboxymethyl) lysine and hexitol-lysine. Free Radical Biology & Medicine. 31: 175-80. PMID 11440829 DOI: 10.1016/S0891-5849(01)00570-6  0.593
2001 Sayre LM, Smith MA, Perry G. Chemistry and biochemistry of oxidative stress in neurodegenerative disease. Current Medicinal Chemistry. 8: 721-38. PMID 11375746 DOI: 10.2174/0929867013372922  0.609
2001 Lee Y, Jeon HB, Huang H, Sayre LM. Temporary inactivation of plasma amine oxidase by alkylhydrazines. A combined enzyme/model study implicates cofactor reduction/reoxidation but cofactor deoxygenation and subsequent reoxygenation in the case of hydrazine itself. The Journal of Organic Chemistry. 66: 1925-37. PMID 11300883 DOI: 10.1021/jo001115o  0.568
2001 Li WS, Sayre LM. Reaction of amines with N1,N10-ethylene-bridged flavinium salts: The first NMR spectroscopic evidence of C10a tetrahedral amine adducts Tetrahedron. 57: 4523-4536. DOI: 10.1016/S0040-4020(01)00314-3  0.547
2001 Li WS, Zhang N, Sayre LM. N1,N10-Ethylene-bridged high-potential flavins: Synthesis, characterization, and reactivity Tetrahedron. 57: 4507-4522. DOI: 10.1016/S0040-4020(01)00313-1  0.59
2000 Rottkamp CA, Nunomura A, Hirai K, Sayre LM, Perry G, Smith MA. Will antioxidants fulfill their expectations for the treatment of Alzheimer disease? Mechanisms of Ageing and Development. 116: 169-79. PMID 10996017 DOI: 10.1016/S0047-6374(00)00124-X  0.532
2000 Takeda A, Smith MA, Avilá J, Nunomura A, Siedlak SL, Zhu X, Perry G, Sayre LM. In Alzheimer's disease, heme oxygenase is coincident with Alz50, an epitope of tau induced by 4-hydroxy-2-nonenal modification. Journal of Neurochemistry. 75: 1234-41. PMID 10936206 DOI: 10.1046/J.1471-4159.2000.0751234.X  0.57
2000 Salomon RG, Kaur K, Podrez E, Hoff HF, Krushinsky AV, Sayre LM. HNE-derived 2-pentylpyrroles are generated during oxidation of LDL, are more prevalent in blood plasma from patients with renal disease or atherosclerosis, and are present in atherosclerotic plaques. Chemical Research in Toxicology. 13: 557-64. PMID 10898587 DOI: 10.1021/Tx000007U  0.378
2000 Rottkamp CA, Nunomura A, Raina AK, Sayre LM, Perry G, Smith MA. Oxidative stress, antioxidants, and Alzheimer disease. Alzheimer Disease and Associated Disorders. 14: S62-6. PMID 10850732 DOI: 10.1097/00002093-200000001-00010  0.598
2000 Raina AK, Perry G, Nunomura A, Sayre LM, Smith MA. Histochemical and immunocytochemical approaches to the study of oxidative stress. Clinical Chemistry and Laboratory Medicine : Cclm / Fescc. 38: 93-7. PMID 10834395 DOI: 10.1515/Cclm.2000.015  0.553
2000 Xu G, Liu Y, Sayre LM. Polyclonal antibodies to a fluorescent 4-hydroxy-2-nonenal (HNE)-derived lysine-lysine cross-link: characterization and application to HNE-treated protein and in vitro oxidized low-density lipoprotein. Chemical Research in Toxicology. 13: 406-13. PMID 10813658 DOI: 10.1021/Tx990200S  0.634
2000 Perry G, Raina AK, Nunomura A, Wataya T, Sayre LM, Smith MA. How important is oxidative damage? Lessons from Alzheimer's disease. Free Radical Biology & Medicine. 28: 831-4. PMID 10754280 DOI: 10.1016/S0891-5849(00)00158-1  0.579
2000 Sayre LM, Perry G, Harris PL, Liu Y, Schubert KA, Smith MA. In situ oxidative catalysis by neurofibrillary tangles and senile plaques in Alzheimer's disease: a central role for bound transition metals. Journal of Neurochemistry. 74: 270-9. PMID 10617129 DOI: 10.1046/J.1471-4159.2000.0740270.X  0.744
1999 Sayre LM, Perry G, Smith MA. In situ methods for detection and localization of markers of oxidative stress: application in neurodegenerative disorders. Methods in Enzymology. 309: 133-52. PMID 10507022 DOI: 10.1016/S0076-6879(99)09012-6  0.599
1999 Xu G, Liu Y, Kansal MM, Sayre LM. Rapid cross-linking of proteins by 4-ketoaldehydes and 4-hydroxy-2-alkenals does not arise from the lysine-derived monoalkylpyrroles. Chemical Research in Toxicology. 12: 855-61. PMID 10490508 DOI: 10.1021/Tx990056A  0.642
1999 Sayre LM, Perry G, Smith MA. Redox metals and neurodegenerative disease. Current Opinion in Chemical Biology. 3: 220-5. PMID 10226049 DOI: 10.1016/S1367-5931(99)80035-0  0.57
1999 Xu G, Liu Y, Sayre LM. Independent synthesis, solution behavior, and studies on the mechanism of formation of a primary amine-derived fluorophore representing cross- linking of proteins by (E)-4-hydroxy-2-nonenal Journal of Organic Chemistry. 64: 5732-5745. DOI: 10.1021/Jo982523J  0.675
1998 Lee Y, Sayre LM. Reaffirmation that metabolism of polyamines by bovine plasma amine oxidase occurs strictly at the primary amino termini. The Journal of Biological Chemistry. 273: 19490-4. PMID 9677370 DOI: 10.1074/Jbc.273.31.19490  0.329
1998 Smith MA, Sayre LM, Anderson VE, Harris PL, Beal MF, Kowall N, Perry G. Cytochemical demonstration of oxidative damage in Alzheimer disease by immunochemical enhancement of the carbonyl reaction with 2,4-dinitrophenylhydrazine. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 46: 731-5. PMID 9603784 DOI: 10.1177/002215549804600605  0.554
1998 Xu G, Sayre LM. Structural characterization of a 4-hydroxy-2-alkenal-derived fluorophore that contributes to lipoperoxidation-dependent protein cross-linking in aging and degenerative disease. Chemical Research in Toxicology. 11: 247-51. PMID 9548794 DOI: 10.1021/tx980003d  0.351
1998 Castellani RJ, Perry G, Harris PL, Cohen ML, Sayre LM, Salomon RG, Smith MA. Advanced lipid peroxidation end-products in Alexander's disease. Brain Research. 787: 15-8. PMID 9518535 DOI: 10.1016/S0006-8993(97)01224-9  0.521
1998 Perry G, Wataya T, Nunomura A, Szweda L, Sayre LM, Smith MA. NEUROFILAMENT HEAVY SUBUNIT (NFH) IS A SPECIFIC TARGET OF OXIDATIVE DAMAGE IN THE AXON Journal of Neuropathology and Experimental Neurology. 57: 492. DOI: 10.1097/00005072-199805000-00101  0.421
1997 Hoppe G, O'Neil J, Sayre LM, Hoff HF. Non-conventional modification of low density lipoproteins: chemical models for macrophage recognition of oxidized LDL. Biochimica Et Biophysica Acta. 1362: 103-8. PMID 9540840 DOI: 10.1016/S0925-4439(97)00091-4  0.309
1997 Smith MA, Harris PL, Sayre LM, Perry G. Iron accumulation in Alzheimer disease is a source of redox-generated free radicals. Proceedings of the National Academy of Sciences of the United States of America. 94: 9866-8. PMID 9275217 DOI: 10.1073/Pnas.94.18.9866  0.559
1997 Sayre LM, Zagorski MG, Surewicz WK, Krafft GA, Perry G. Mechanisms of neurotoxicity associated with amyloid beta deposition and the role of free radicals in the pathogenesis of Alzheimer's disease: a critical appraisal. Chemical Research in Toxicology. 10: 518-26. PMID 9168248 DOI: 10.1021/Tx970009N  0.452
1997 Sayre LM, Zelasko DA, Harris PL, Perry G, Salomon RG, Smith MA. 4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease. Journal of Neurochemistry. 68: 2092-7. PMID 9109537 DOI: 10.1046/J.1471-4159.1997.68052092.X  0.506
1997 Smith MA, Richey Harris PL, Sayre LM, Beckman JS, Perry G. Widespread peroxynitrite-mediated damage in Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 2653-7. PMID 9092586  0.343
1997 Smith MA, Richey Harris PL, Sayre LM, Beckman JS, Perry G. Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease The Journal of Neuroscience. 17: 2653-2657. DOI: 10.1523/Jneurosci.17-08-02653.1997  0.543
1997 Perry G, Zelasko DA, Sayre LM, Smith MA. Oxidative Damage to Axonal Cytoskeletal Proteins Microscopy and Microanalysis. 3: 43-44. DOI: 10.1017/S1431927600007108  0.316
1996 Sayre LM, Sha W, Xu G, Kaur K, Nadkarni D, Subbanagounder G, Salomon RG. Immunochemical evidence supporting 2-pentylpyrrole formation on proteins exposed to 4-hydroxy-2-nonenal. Chemical Research in Toxicology. 9: 1194-201. PMID 8902276 DOI: 10.1021/Tx960094J  0.336
1996 Smith MA, Sayre LM, Monnier VM, Perry G. Oxidative posttranslational modifications in Alzheimer disease. A possible pathogenic role in the formation of senile plaques and neurofibrillary tangles. Molecular and Chemical Neuropathology / Sponsored by the International Society For Neurochemistry and the World Federation of Neurology and Research Groups On Neurochemistry and Cerebrospinal Fluid. 28: 41-8. PMID 8871940 DOI: 10.1007/Bf02815203  0.592
1996 Sayre LM, Naismith RT, Bada MA, Li WS, Klein ME, Tennant MD. trans-2-phenylcyclopropylamine is a substrate for and inactivator of horseradish peroxidase. Biochimica Et Biophysica Acta. 1296: 250-6. PMID 8814233 DOI: 10.1016/0167-4838(96)00084-2  0.616
1996 Smith MA, Perry G, Richey PL, Sayre LM, Anderson VE, Beal MF, Kowall N. Oxidative damage in Alzheimer's. Nature. 382: 120-1. PMID 8700201 DOI: 10.1038/382120B0  0.482
1996 Smith M, Sayre L, Anderson V, Richey P, Siedlak S, Beal M, Kowall N, Perry G. 809 A specific marker of oxidative protein modifications, 2,4-dinitrophenylhydrazine, labels the neurofibrillary pathology of Alzheimer disease Neurobiology of Aging. 17: S201. DOI: 10.1016/S0197-4580(96)80811-6  0.6
1995 Smith MA, Monnier VM, Sayre LM, Perry G. Amyloidosis, advanced glycation end products and Alzheimer disease. Neuroreport. 6: 1595-6. PMID 8527721 DOI: 10.1097/00001756-199508000-00001  0.531
1995 Sayre LM, Lee Y. Catalytic aerobic deamination of activated primary amines by a model for the quinone cofactor of mammalian copper amine oxidases. Methods in Enzymology. 258: 53-69. PMID 8524164 DOI: 10.1016/0076-6879(95)58037-9  0.302
1995 Smith MA, Sayre LM, Vitek MP, Monnier VM, Perry G. Early AGEing and Alzheimer's. Nature. 374: 316. PMID 7885469 DOI: 10.1038/374316B0  0.423
1995 Smith MA, Sayre LM, Monnier VM, Perry G. Radical AGEing in Alzheimer's disease. Trends in Neurosciences. 18: 172-6. PMID 7778188 DOI: 10.1016/0166-2236(95)93897-7  0.579
1995 Smith MA, Rudnicka-Nawrot M, Richey PL, Praprotnik D, Mulvihill P, Miller CA, Sayre LM, Perry G. Carbonyl-related posttranslational modification of neurofilament protein in the neurofibrillary pathology of Alzheimer's disease. Journal of Neurochemistry. 64: 2660-6. PMID 7539057 DOI: 10.1046/J.1471-4159.1995.64062660.X  0.582
1995 He Z, Nadkarni DV, Sayre LM, Greenaway FT. Mechanism-based inactivation of porcine kidney diamine oxidase by 1,4-diamino-2-butene. Biochimica Et Biophysica Acta. 1253: 117-27. PMID 7492592 DOI: 10.1016/0167-4838(95)00158-Q  0.372
1995 Sayre LM, Engelhart DA, Nadkarni DV, Babu MK, Klein ME, McCoy G. Haemoprotein-mediated metabolism of enamines and the possible involvement of one-electron oxidations. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 25: 769-75. PMID 7483673 DOI: 10.3109/00498259509061892  0.323
1995 Smith MA, Richey PL, Praprotnik D, Mulvihill P, Sayre LM, Perry G. Carbonyl-Related Modification of Neurofilaments in Aizheimer Disease Journal of Neuropathology and Experimental Neurology. 54: 434. DOI: 10.1097/00005072-199505000-00109  0.444
1994 Smith MA, Taneda S, Richey PL, Miyata S, Yan SD, Stern D, Sayre LM, Monnier VM, Perry G. Advanced Maillard reaction end products are associated with Alzheimer disease pathology. Proceedings of the National Academy of Sciences of the United States of America. 91: 5710-4. PMID 8202552 DOI: 10.1073/Pnas.91.12.5710  0.581
1994 Smith MA, Richey PL, Taneda S, Kutty RK, Sayre LM, Monnier VM, Perry G. Advanced Maillard reaction end products, free radicals, and protein oxidation in Alzheimer's disease. Annals of the New York Academy of Sciences. 738: 447-54. PMID 7832455 DOI: 10.1111/J.1749-6632.1994.Tb21836.X  0.571
1993 Sayre LM, Arora PK, Iyer RS, Salomon RG. Pyrrole formation from 4-hydroxynonenal and primary amines. Chemical Research in Toxicology. 6: 19-22. PMID 8448343 DOI: 10.1021/Tx00031A002  0.364
1992 Sayre LM, Tang W, Reddy KV, Nadkarni D. Copper-Mediated Nitrogen Ligand Oxidation and Oxygenation Journal of Inorganic Biochemistry. 47: 236-248. DOI: 10.1007/978-94-011-6875-5_19  0.346
1991 Sayre LM, Wang FJ, Arora PK, Riachi NJ, Harik SI, Hoppel CL. Dopaminergic neurotoxicity in vivo and inhibition of mitochondrial respiration in vitro by possible endogenous pyridinium-like substances. Journal of Neurochemistry. 57: 2106-15. PMID 1940917 DOI: 10.1111/J.1471-4159.1991.Tb06429.X  0.319
1991 Sayre LM, Engelhart DA, Venkataraman B, Babu MK, McCoy GD. Generation and fate of enamines in the microsomal metabolism of cyclic tertiary amines. Biochemical and Biophysical Research Communications. 179: 1368-76. PMID 1930182 DOI: 10.1016/0006-291X(91)91724-Q  0.346
1991 Arora PK, Sayre LM. Copper-ammonia mediated oxidation of carbonyl compounds Tetrahedron Letters. 32: 1007-1010. DOI: 10.1016/S0040-4039(00)74473-X  0.39
1990 Sayre LM, Singh MP, Arora PK, Wang F, McPeak RJ, Hoppel CL. Inhibition of mitochondrial respiration by analogues of the dopaminergic neurotoxin 1-methyl-4-phenylpyridinium: structural requirements for accumulation-dependent enhanced inhibitory potency on intact mitochondria. Archives of Biochemistry and Biophysics. 280: 274-83. PMID 2369119 DOI: 10.1016/0003-9861(90)90330-2  0.311
1990 Arora PK, Riachi NJ, Fiedler GC, Singh MP, Abdallah F, Harik SI, Sayre LM. Structure-neurotoxicity trends of analogues of 1-methyl-4-phenylpyridinium (MPP+), the cytotoxic metabolite of the dopaminergic neurotoxin MPTP. Life Sciences. 46: 379-90. PMID 2304377 DOI: 10.1016/0024-3205(90)90018-M  0.301
1989 Wang F, Sayre LM. Oxidation of tertiary amine buffers by copper(II) Inorganic Chemistry. 28: 169-170. DOI: 10.1021/Ic00301A001  0.331
1988 Arora PK, Riachi NJ, Harik SI, Sayre LM. Chemical oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its in vivo metabolism in rat brain and liver. Biochemical and Biophysical Research Communications. 152: 1339-47. PMID 3259874 DOI: 10.1016/S0006-291X(88)80432-7  0.307
1988 Riachi NJ, Arora PK, Sayre LM, Harik SI. Potent neurotoxic fluorinated 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine analogs as potential probes in models of Parkinson disease. Journal of Neurochemistry. 50: 1319-21. PMID 3258018 DOI: 10.1111/J.1471-4159.1988.Tb10610.X  0.305
1987 Hoppel CL, Grinblatt D, Kwok HC, Arora PK, Singh MP, Sayre LM, Greenblatt D. Inhibition of mitochondrial respiration by analogs of 4-phenylpyridine and 1-methyl-4-phenylpyridinium cation (MPP+), the neurotoxic metabolite of MPTP. Biochemical and Biophysical Research Communications. 148: 684-93. PMID 3500717 DOI: 10.1016/0006-291X(87)90931-4  0.302
1987 Frank DM, Arora PK, Blumer JL, Sayre LM. Model study on the bioreduction of paraquat, MPP+, and analogs. Evidence against a "redox cycling" mechanism in MPTP neurotoxicity. Biochemical and Biophysical Research Communications. 147: 1095-104. PMID 3499150 DOI: 10.1016/S0006-291X(87)80183-3  0.369
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