Alan V. Smrcka - Publications

Affiliations: 
University of Rochester, Rochester, NY 
Area:
Pharmacology, Biochemistry

93 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Knight KM, Ghosh S, Campbell SL, Lefevre TJ, Olsen RHJ, Smrcka AV, Valentin NH, Yin G, Vaidehi N, Dohlman HG. A universal allosteric mechanism for G protein activation. Molecular Cell. PMID 33636126 DOI: 10.1016/j.molcel.2021.02.002  0.56
2020 Fisher IJ, Jenkins ML, Tall GG, Burke JE, Smrcka AV. Activation of Phospholipase C β by Gβγ and Gα Involves C-Terminal Rearrangement to Release Autoinhibition. Structure (London, England : 1993). PMID 32402248 DOI: 10.1016/J.Str.2020.04.012  1
2020 Cash JN, Chandan NR, Hsu AY, Sharma PV, Deng Q, Smrcka AV, Tesmer JJG. Discovery of small molecules that target the P-Rex1 PIP3-binding site and inhibit P-Rex1-dependent functions in neutrophils. Molecular Pharmacology. PMID 31900312 DOI: 10.1124/Mol.119.117556  0.44
2019 Smrcka AV, Fisher I. G-protein βγ subunits as multi-functional scaffolds and transducers in G-protein-coupled receptor signaling. Cellular and Molecular Life Sciences : Cmls. PMID 31435698 DOI: 10.1007/S00018-019-03275-2  1
2019 Nash CA, Wei W, Irannejad R, Smrcka AV. Golgi localized β1-adrenergic receptors stimulate Golgi PI4P hydrolysis by PLCε to regulate cardiac hypertrophy. Elife. 8. PMID 31433293 DOI: 10.7554/Elife.48167  1
2019 Gaylo-Moynihan A, Prizant H, Popović M, Fernandes NRJ, Anderson CS, Chiou KK, Bell H, Schrock DC, Schumacher J, Capece T, Walling BL, Topham DJ, Miller J, Smrcka AV, Kim M, et al. Programming of Distinct Chemokine-Dependent and -Independent Search Strategies for Th1 and Th2 Cells Optimizes Function at Inflamed Sites. Immunity. PMID 31399281 DOI: 10.1016/J.Immuni.2019.06.026  0.44
2018 de Rubio RG, Ransom RF, Malik S, Yule DI, Anantharam A, Smrcka AV. Phosphatidylinositol 4-phosphate is a major source of GPCR-stimulated phosphoinositide production. Science Signaling. 11. PMID 30206135 DOI: 10.1126/Scisignal.Aan1210  1
2018 Nash CA, Brown LM, Malik S, Cheng X, Smrcka AV. Compartmentalized cyclic nucleotides have opposing effects on regulation of hypertrophic phospholipase Cε signaling in cardiac myocytes. Journal of Molecular and Cellular Cardiology. PMID 29885334 DOI: 10.1016/J.Yjmcc.2018.06.002  1
2018 Madukwe JC, Garland-Kuntz EE, Lyon AM, Smrcka AV. G protein βγ subunits directly interact with and activate phospholipase Cε. The Journal of Biological Chemistry. PMID 29535186 DOI: 10.1074/Jbc.Ra118.002354  0.52
2018 Stoveken HM, Larsen SD, Smrcka AV, Tall GG. Gedunin- and Khivorin-Derivatives are Small Molecule Partial Agonists for Adhesion G protein Coupled Receptors GPR56 / ADGRG1 and GPR114 / ADGRG5. Molecular Pharmacology. PMID 29476042 DOI: 10.1124/Mol.117.111476  0.64
2017 To JY, Smrcka AV. Activated Heterotrimeric G protein αi Subunits Inhibit Rap-Dependent Cell Adhesion and Promote Cell Migration. The Journal of Biological Chemistry. PMID 29259127 DOI: 10.1074/Jbc.Ra117.000964  0.44
2017 Kim KD, Bae S, Capece T, Nedelkovska H, de Rubio RG, Smrcka AV, Jun CD, Jung W, Park B, Kim TI, Kim M. Targeted calcium influx boosts cytotoxic T lymphocyte function in the tumour microenvironment. Nature Communications. 8: 15365. PMID 28504276 DOI: 10.1038/Ncomms15365  1
2017 Tong J, Liu X, Vickstrom C, Li Y, Yu L, Lu Y, Smrcka AV, Liu QS. The Epac-phospholipase Cε pathway regulates endocannabinoid signaling and cocaine-induced disinhibition of VTA dopamine neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28209735 DOI: 10.1523/Jneurosci.2810-16.2017  0.44
2016 Stoveken HM, Bahr LL, Anders MW, Wojtovich AP, Smrcka AV, Tall GG. Dihydromunduletone is a Small-Molecule Selective Adhesion G Protein-Coupled Receptor Antagonist. Molecular Pharmacology. PMID 27338081 DOI: 10.1124/Mol.116.104828  0.68
2016 Rangel-Moreno J, To JY, Owen T, Goldman BI, Smrcka AV, Anolik JH. Inhibition of G protein βγ subunit signaling abrogates nephritis in lupus prone mice. Arthritis & Rheumatology (Hoboken, N.J.). PMID 26990948 DOI: 10.1002/Art.39673  0.44
2016 Surve CR, To JY, Malik S, Kim M, Smrcka AV. Dynamic regulation of neutrophil polarity and migration by the heterotrimeric G protein subunits Gαi-GTP and Gβγ. Science Signaling. 9: ra22. PMID 26905427 DOI: 10.1126/Scisignal.Aad8163  1
2015 Dusaban SS, Kunkel MT, Smrcka AV, Brown JH. Thrombin Promotes Sustained Signaling and Inflammatory Gene Expression through the CDC25 and Ras-associating Domains of Phospholipase Cϵ. The Journal of Biological Chemistry. 290: 26776-83. PMID 26350460 DOI: 10.1074/Jbc.M115.676098  0.68
2015 Brand CS, Sadana R, Malik S, Smrcka AV, Dessauer CW. Adenylyl Cyclase 5 Regulation by Gβγ Involves Isoform-Specific Use of Multiple Interaction Sites. Molecular Pharmacology. 88: 758-67. PMID 26206488 DOI: 10.1124/Mol.115.099556  0.68
2015 Malik S, deRubio RG, Trembley M, Irannejad R, Wedegaertner PB, Smrcka AV. G protein βγ subunits regulate cardiomyocyte hypertrophy through a perinuclear Golgi phosphatidylinositol 4-phosphate hydrolysis pathway. Molecular Biology of the Cell. 26: 1188-98. PMID 25609085 DOI: 10.1091/Mbc.E14-10-1476  0.68
2015 Kalwa H, Storch U, Demleitner J, Fiedler S, Mayer T, Kannler M, Fahlbusch M, Barth H, Smrcka A, Hildebrandt F, Gudermann T, Dietrich A. Phospholipase C epsilon (PLCε) induced TRPC6 activation: a common but redundant mechanism in primary podocytes. Journal of Cellular Physiology. 230: 1389-99. PMID 25521631 DOI: 10.1002/Jcp.24883  0.68
2014 Le NT, Takei Y, Izawa-Ishizawa Y, Heo KS, Lee H, Smrcka AV, Miller BL, Ko KA, Ture S, Morrell C, Fujiwara K, Akaike M, Abe J. Identification of activators of ERK5 transcriptional activity by high-throughput screening and the role of endothelial ERK5 in vasoprotective effects induced by statins and antimalarial agents. Journal of Immunology (Baltimore, Md. : 1950). 193: 3803-15. PMID 25187658 DOI: 10.4049/Jimmunol.1400571  0.68
2014 Oldenburger A, Timens W, Bos S, Smit M, Smrcka AV, Laurent AC, Cao J, Hylkema M, Meurs H, Maarsingh H, Lezoualc'h F, Schmidt M. Epac1 and Epac2 are differentially involved in inflammatory and remodeling processes induced by cigarette smoke. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 4617-28. PMID 25103224 DOI: 10.1096/Fj.13-248930  0.68
2014 Surve CR, Lehmann D, Smrcka AV. A chemical biology approach demonstrates G protein βγ subunits are sufficient to mediate directional neutrophil chemotaxis. The Journal of Biological Chemistry. 289: 17791-801. PMID 24808183 DOI: 10.1074/Jbc.M114.576827  0.68
2014 Kamal FA, Mickelsen DM, Wegman KM, Travers JG, Moalem J, Hammes SR, Smrcka AV, Blaxall BC. Simultaneous adrenal and cardiac g-protein-coupled receptor-gβγ inhibition halts heart failure progression. Journal of the American College of Cardiology. 63: 2549-57. PMID 24703913 DOI: 10.1016/J.Jacc.2014.02.587  0.68
2014 Kan W, Adjobo-Hermans M, Burroughs M, Faibis G, Malik S, Tall GG, Smrcka AV. M3 muscarinic receptor interaction with phospholipase C β3 determines its signaling efficiency. The Journal of Biological Chemistry. 289: 11206-18. PMID 24596086 DOI: 10.1074/Jbc.M113.538546  1
2014 Ruisanchez É, Dancs P, Kerék M, Németh T, Faragó B, Balogh A, Patil R, Jennings BL, Liliom K, Malik KU, Smrcka AV, Tigyi G, Benyó Z. Lysophosphatidic acid induces vasodilation mediated by LPA1 receptors, phospholipase C, and endothelial nitric oxide synthase. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 880-90. PMID 24249637 DOI: 10.1096/Fj.13-234997  0.68
2013 Xiang SY, Ouyang K, Yung BS, Miyamoto S, Smrcka AV, Chen J, Brown JH. PLCε, PKD1, and SSH1L transduce RhoA signaling to protect mitochondria from oxidative stress in the heart Science Signaling. 6. PMID 24345679 DOI: 10.1126/Scisignal.2004405  0.68
2013 Easterhoff D, DiMaio JT, Liyanage W, Lo CW, Bae W, Doran TM, Smrcka A, Nilsson BL, Dewhurst S. Fluorescence detection of cationic amyloid fibrils in human semen. Bioorganic & Medicinal Chemistry Letters. 23: 5199-202. PMID 23910594 DOI: 10.1016/J.Bmcl.2013.06.097  0.68
2013 Sun Z, Smrcka AV, Chen S. WDR26 functions as a scaffolding protein to promote Gβγ-mediated phospholipase C β2 (PLCβ2) activation in leukocytes. The Journal of Biological Chemistry. 288: 16715-25. PMID 23625927 DOI: 10.1074/Jbc.M113.462564  0.68
2013 Zhang L, Malik S, Pang J, Wang H, Park KM, Yule DI, Blaxall BC, Smrcka AV. Phospholipase Cε hydrolyzes perinuclear phosphatidylinositol 4-phosphate to regulate cardiac hypertrophy. Cell. 153: 216-27. PMID 23540699 DOI: 10.1016/J.Cell.2013.02.047  1
2013 Dusaban SS, Purcell NH, Rockenstein E, Masliah E, Cho MK, Smrcka AV, Brown JH. Phospholipase C epsilon links G protein-coupled receptor activation to inflammatory astrocytic responses. Proceedings of the National Academy of Sciences of the United States of America. 110: 3609-14. PMID 23401561 DOI: 10.1073/Pnas.1217355110  0.68
2012 Dbouk HA, Vadas O, Shymanets A, Burke JE, Salamon RS, Khalil BD, Barrett MO, Waldo GL, Surve C, Hsueh C, Perisic O, Harteneck C, Shepherd PR, Harden TK, Smrcka AV, et al. G protein-coupled receptor-mediated activation of p110β by Gβγ is required for cellular transformation and invasiveness. Science Signaling. 5: ra89. PMID 23211529 DOI: 10.1126/Scisignal.2003264  0.68
2012 McCoy KL, Gyoneva S, Vellano CP, Smrcka AV, Traynelis SF, Hepler JR. Protease-activated receptor 1 (PAR1) coupling to G(q/11) but not to G(i/o) or G(12/13) is mediated by discrete amino acids within the receptor second intracellular loop. Cellular Signalling. 24: 1351-60. PMID 22306780 DOI: 10.1016/J.Cellsig.2012.01.011  0.68
2012 Smrcka AV, Brown JH, Holz GG. Role of phospholipase Cε in physiological phosphoinositide signaling networks. Cellular Signalling. 24: 1333-43. PMID 22286105 DOI: 10.1016/J.Cellsig.2012.01.009  0.68
2011 Lin Y, Smrcka AV. Understanding molecular recognition by G protein βγ subunits on the path to pharmacological targeting. Molecular Pharmacology. 80: 551-7. PMID 21737569 DOI: 10.1124/Mol.111.073072  0.4
2011 Seneviratne AM, Burroughs M, Giralt E, Smrcka AV. Direct-reversible binding of small molecules to G protein βγ subunits. Biochimica Et Biophysica Acta. 1814: 1210-8. PMID 21621014 DOI: 10.1016/J.Bbapap.2011.05.010  0.52
2011 Zhang L, Malik S, Kelley GG, Kapiloff MS, Smrcka AV. Phospholipase C epsilon scaffolds to muscle-specific A kinase anchoring protein (mAKAPbeta) and integrates multiple hypertrophic stimuli in cardiac myocytes. The Journal of Biological Chemistry. 286: 23012-21. PMID 21550986 DOI: 10.1074/Jbc.M111.231993  1
2011 Dzhura I, Chepurny OG, Leech CA, Roe MW, Dzhura E, Xu X, Lu Y, Schwede F, Genieser HG, Smrcka AV, Holz GG. Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans. Islets. 3: 121-8. PMID 21478675 DOI: 10.4161/Isl.3.3.15507  0.68
2011 Kamal FA, Smrcka AV, Blaxall BC. Taking the heart failure battle inside the cell: small molecule targeting of Gβγ subunits. Journal of Molecular and Cellular Cardiology. 51: 462-7. PMID 21256851 DOI: 10.1016/J.Yjmcc.2011.01.006  0.68
2011 Chan P, Gabay M, Wright FA, Kan W, Oner SS, Lanier SM, Smrcka AV, Blumer JB, Tall GG. Purification of heterotrimeric G protein alpha subunits by GST-Ric-8 association: primary characterization of purified G alpha(olf). The Journal of Biological Chemistry. 286: 2625-35. PMID 21115479 DOI: 10.1074/Jbc.M110.178897  0.68
2011 Park MS, Smrcka AV, Stern HA. Conformational flexibility and binding interactions of the G protein βγ heterodimer. Proteins. 79: 518-27. PMID 21064128 DOI: 10.1002/Prot.22899  0.68
2011 Dessal AL, Prades R, Giralt E, Smrcka AV. Rational design of a selective covalent modifier of G protein βγ subunits. Molecular Pharmacology. 79: 24-33. PMID 20881007 DOI: 10.1124/Mol.110.068155  0.64
2010 Dzhura I, Chepurny OG, Kelley GG, Leech CA, Roe MW, Dzhura E, Afshari P, Malik S, Rindler MJ, Xu X, Lu Y, Smrcka AV, Holz GG. Epac2-dependent mobilization of intracellular Ca²+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in β-cells of phospholipase C-ε knockout mice. The Journal of Physiology. 588: 4871-89. PMID 21041529 DOI: 10.1113/Jphysiol.2010.198424  0.68
2010 Gaudy AM, Clementi AH, Campbell JS, Smrcka AV, Mooney RA. Suppressor of cytokine signaling-3 is a glucagon-inducible inhibitor of PKA activity and gluconeogenic gene expression in hepatocytes. The Journal of Biological Chemistry. 285: 41356-65. PMID 20978125 DOI: 10.1074/Jbc.M110.159111  0.68
2010 Casey LM, Pistner AR, Belmonte SL, Migdalovich D, Stolpnik O, Nwakanma FE, Vorobiof G, Dunaevsky O, Matavel A, Lopes CM, Smrcka AV, Blaxall BC. Small molecule disruption of G beta gamma signaling inhibits the progression of heart failure. Circulation Research. 107: 532-9. PMID 20576935 DOI: 10.1161/Circresaha.110.217075  0.52
2010 Smrcka AV, Kichik N, Tarragó T, Burroughs M, Park MS, Itoga NK, Stern HA, Willardson BM, Giralt E. NMR analysis of G-protein betagamma subunit complexes reveals a dynamic G(alpha)-Gbetagamma subunit interface and multiple protein recognition modes. Proceedings of the National Academy of Sciences of the United States of America. 107: 639-44. PMID 20018744 DOI: 10.1073/Pnas.0909503107  0.68
2010 Serasinghe MN, Seneviratne AM, Smrcka AV, Yoon Y. Identification and characterization of unique proline-rich peptides binding to the mitochondrial fission protein hFis1. The Journal of Biological Chemistry. 285: 620-30. PMID 19864424 DOI: 10.1074/Jbc.M109.027508  0.68
2009 Wang Z, Kumamoto Y, Wang P, Gan X, Lehmann D, Smrcka AV, Cohn L, Iwasaki A, Li L, Wu D. Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5. The Journal of Biological Chemistry. 284: 28599-606. PMID 19713215 DOI: 10.1074/Jbc.M109.047282  0.68
2009 Park MS, Dessal AL, Smrcka AV, Stern HA. Evaluating docking methods for prediction of binding affinities of small molecules to the G protein betagamma subunits. Journal of Chemical Information and Modeling. 49: 437-43. PMID 19434844 DOI: 10.1021/Ci800384Q  0.68
2009 Oestreich EA, Malik S, Goonasekera SA, Blaxall BC, Kelley GG, Dirksen RT, Smrcka AV. Epac and phospholipase Cepsilon regulate Ca2+ release in the heart by activation of protein kinase Cepsilon and calcium-calmodulin kinase II. The Journal of Biological Chemistry. 284: 1514-22. PMID 18957419 DOI: 10.1074/Jbc.M806994200  0.68
2008 Mathews JL, Smrcka AV, Bidlack JM. A novel Gbetagamma-subunit inhibitor selectively modulates mu-opioid-dependent antinociception and attenuates acute morphine-induced antinociceptive tolerance and dependence. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 12183-9. PMID 19020012 DOI: 10.1523/Jneurosci.2326-08.2008  0.4
2008 Smrcka AV, Lehmann DM, Dessal AL. G protein betagamma subunits as targets for small molecule therapeutic development. Combinatorial Chemistry & High Throughput Screening. 11: 382-95. PMID 18537559 DOI: 10.2174/138620708784534761  0.64
2008 Smrcka AV. G protein βγ subunits: central mediators of G protein-coupled receptor signaling. Cellular and Molecular Life Sciences : Cmls. 65: 2191-214. PMID 18488142 DOI: 10.1007/S00018-008-8006-5  0.64
2008 Lehmann DM, Seneviratne AM, Smrcka AV. Small molecule disruption of G protein beta gamma subunit signaling inhibits neutrophil chemotaxis and inflammation. Molecular Pharmacology. 73: 410-8. PMID 18006643 DOI: 10.1124/Mol.107.041780  0.64
2007 Lehmann DM, Yuan C, Smrcka AV. Analysis and pharmacological targeting of phospholipase C beta interactions with G proteins. Methods in Enzymology. 434: 29-48. PMID 17954241 DOI: 10.1016/S0076-6879(07)34003-2  0.64
2007 Smrcka AV, Oestreich EA, Blaxall BC, Dirksen RT. EPAC regulation of cardiac EC coupling. The Journal of Physiology. 584: 1029-31. PMID 17884917 DOI: 10.1113/Jphysiol.2007.145037  0.68
2007 Citro S, Malik S, Oestreich EA, Radeff-Huang J, Kelley GG, Smrcka AV, Brown JH. Phospholipase Cepsilon is a nexus for Rho and Rap-mediated G protein-coupled receptor-induced astrocyte proliferation. Proceedings of the National Academy of Sciences of the United States of America. 104: 15543-8. PMID 17878312 DOI: 10.1073/Pnas.0702943104  1
2007 Yuan C, Sato M, Lanier SM, Smrcka AV. Signaling by a non-dissociated complex of G protein βγ and α subunits stimulated by a receptor-independent activator of G protein signaling, AGS8. The Journal of Biological Chemistry. 282: 19938-47. PMID 17446173 DOI: 10.1074/Jbc.M700396200  0.44
2007 Blumer JB, Smrcka AV, Lanier SM. Mechanistic pathways and biological roles for receptor-independent activators of G-protein signaling. Pharmacology & Therapeutics. 113: 488-506. PMID 17240454 DOI: 10.1016/J.Pharmthera.2006.11.001  0.44
2007 Oestreich EA, Wang H, Malik S, Kaproth-Joslin KA, Blaxall BC, Kelley GG, Dirksen RT, Smrcka AV. Epac-mediated activation of phospholipase C(epsilon) plays a critical role in beta-adrenergic receptor-dependent enhancement of Ca2+ mobilization in cardiac myocytes. The Journal of Biological Chemistry. 282: 5488-95. PMID 17178726 DOI: 10.1074/Jbc.M608495200  0.68
2006 Hinkes B, Wiggins RC, Gbadegesin R, Vlangos CN, Seelow D, Nürnberg G, Garg P, Verma R, Chaib H, Hoskins BE, Ashraf S, Becker C, Hennies HC, Goyal M, Wharram BL, ... ... Smrcka AV, et al. Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible. Nature Genetics. 38: 1397-405. PMID 17086182 DOI: 10.1038/Ng1918  0.68
2006 Bonacci TM, Mathews JL, Yuan C, Lehmann DM, Malik S, Wu D, Font JL, Bidlack JM, Smrcka AV. Differential targeting of Gbetagamma-subunit signaling with small molecules. Science (New York, N.Y.). 312: 443-6. PMID 16627746 DOI: 10.1126/Science.1120378  1
2006 Sato M, Cismowski MJ, Toyota E, Smrcka AV, Lucchesi PA, Chilian WM, Lanier SM. Identification of a receptor-independent activator of G protein signaling (AGS8) in ischemic heart and its interaction with Gbetagamma. Proceedings of the National Academy of Sciences of the United States of America. 103: 797-802. PMID 16407149 DOI: 10.1073/Pnas.0507467103  0.68
2006 Kelley GG, Kaproth-Joslin KA, Reks SE, Smrcka AV, Wojcikiewicz RJ. G-protein-coupled receptor agonists activate endogenous phospholipase Cepsilon and phospholipase Cbeta3 in a temporally distinct manner. The Journal of Biological Chemistry. 281: 2639-48. PMID 16314422 DOI: 10.1074/Jbc.M507681200  0.64
2006 Mahon MJ, Bonacci TM, Divieti P, Smrcka AV. A docking site for G protein βγ subunits on the parathyroid hormone 1 receptor supports signaling through multiple pathways. Molecular Endocrinology (Baltimore, Md.). 20: 136-46. PMID 16099817 DOI: 10.1210/Me.2005-0169  0.64
2005 Wang H, Oestreich EA, Maekawa N, Bullard TA, Vikstrom KL, Dirksen RT, Kelley GG, Blaxall BC, Smrcka AV. Phospholipase C epsilon modulates beta-adrenergic receptor-dependent cardiac contraction and inhibits cardiac hypertrophy. Circulation Research. 97: 1305-13. PMID 16293787 DOI: 10.1161/01.Res.0000196578.15385.Bb  0.68
2005 Davis TL, Bonacci TM, Sprang SR, Smrcka AV. Structural and molecular characterization of a preferred protein interaction surface on G protein beta gamma subunits. Biochemistry. 44: 10593-604. PMID 16060668 DOI: 10.1021/Bi050655I  0.68
2005 Malik S, Ghosh M, Bonacci TM, Tall GG, Smrcka AV. Ric-8 enhances G protein betagamma-dependent signaling in response to betagamma-binding peptides in intact cells. Molecular Pharmacology. 68: 129-36. PMID 15802611 DOI: 10.1124/Mol.104.010116  0.68
2005 Bonacci TM, Ghosh M, Malik S, Smrcka AV. Regulatory interactions between the amino terminus of G-protein betagamma subunits and the catalytic domain of phospholipase Cbeta2. The Journal of Biological Chemistry. 280: 10174-81. PMID 15611108 DOI: 10.1074/Jbc.M412514200  0.68
2004 Kelley GG, Reks SE, Smrcka AV. Hormonal regulation of phospholipase Cepsilon through distinct and overlapping pathways involving G12 and Ras family G-proteins. The Biochemical Journal. 378: 129-39. PMID 14567755 DOI: 10.1042/Bj20031370  0.64
2004 Ghosh M, Smrcka AV. Assay for G protein-dependent activation of phospholipase C beta using purified protein components. Methods in Molecular Biology (Clifton, N.J.). 237: 67-75. PMID 14501039 DOI: 10.1385/1-59259-430-1:67  0.68
2004 Ghosh M, Wang H, Kelley GG, Smrcka AV. Purification of phospholipase C beta and phospholipase C epsilon from Sf9 cells. Methods in Molecular Biology (Clifton, N.J.). 237: 55-64. PMID 14501038 DOI: 10.1385/1-59259-430-1:55  0.68
2003 Li Z, Hannigan M, Mo Z, Liu B, Lu W, Wu Y, Smrcka AV, Wu G, Li L, Liu M, Huang CK, Wu D. Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42. Cell. 114: 215-27. PMID 12887923 DOI: 10.1016/S0092-8674(03)00559-2  0.68
2003 Ghosh M, Peterson YK, Lanier SM, Smrcka AV. Receptor- and nucleotide exchange-independent mechanisms for promoting G protein subunit dissociation. The Journal of Biological Chemistry. 278: 34747-50. PMID 12881533 DOI: 10.1074/Jbc.C300271200  0.68
2003 Goubaeva F, Ghosh M, Malik S, Yang J, Hinkle PM, Griendling KK, Neubig RR, Smrcka AV. Stimulation of cellular signaling and G protein subunit dissociation by G protein betagamma subunit-binding peptides. The Journal of Biological Chemistry. 278: 19634-41. PMID 12649269 DOI: 10.1074/Jbc.M300052200  0.68
2002 Smrcka AV, Scott JK. Discovery of ligands for beta gamma subunits from phage-displayed peptide libraries. Methods in Enzymology. 344: 557-76. PMID 11771410 DOI: 10.1016/S0076-6879(02)44740-4  0.68
2001 Fogg VC, Azpiazu I, Linder ME, Smrcka A, Scarlata S, Gautam N. Role of the gamma subunit prenyl moiety in G protein beta gamma complex interaction with phospholipase Cbeta. The Journal of Biological Chemistry. 276: 41797-802. PMID 11546822 DOI: 10.1074/Jbc.M107661200  0.68
2001 Scott JK, Huang SF, Gangadhar BP, Samoriski GM, Clapp P, Gross RA, Taussig R, Smrcka AV. Evidence that a protein-protein interaction 'hot spot' on heterotrimeric G protein betagamma subunits is used for recognition of a subclass of effectors. The Embo Journal. 20: 767-76. PMID 11179221 DOI: 10.1093/Emboj/20.4.767  0.68
2001 Yoshikawa DM, Bresciano K, Hatwar M, Smrcka AV. Characterization of a phospholipase C beta 2-binding site near the amino-terminal coiled-coil of G protein beta gamma subunits. The Journal of Biological Chemistry. 276: 11246-51. PMID 11145956 DOI: 10.1074/Jbc.M006073200  0.88
2000 Yoshikawa DM, Hatwar M, Smrcka AV. G protein beta 5 subunit interactions with alpha subunits and effectors. Biochemistry. 39: 11340-7. PMID 10985779 DOI: 10.1021/Bi0005557  0.88
2000 Li Z, Jiang H, Xie W, Zhang Z, Smrcka AV, Wu D. Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction. Science (New York, N.Y.). 287: 1046-9. PMID 10669417 DOI: 10.1126/Science.287.5455.1046  0.4
1999 Xie W, Samoriski GM, McLaughlin JP, Romoser VA, Smrcka A, Hinkle PM, Bidlack JM, Gross RA, Jiang H, Wu D. Genetic alteration of phospholipase C beta3 expression modulates behavioral and cellular responses to mu opioids. Proceedings of the National Academy of Sciences of the United States of America. 96: 10385-90. PMID 10468617 DOI: 10.1073/Pnas.96.18.10385  0.68
1996 Jiang H, Kuang Y, Wu Y, Smrcka A, Simon MI, Wu D. Pertussis toxin-sensitive activation of phospholipase C by the C5a and fMet-Leu-Phe receptors. The Journal of Biological Chemistry. 271: 13430-4. PMID 8662841 DOI: 10.1074/Jbc.271.23.13430  0.52
1996 Kuang Y, Wu Y, Smrcka A, Jiang H, Wu D. Identification of a phospholipase C beta2 region that interacts with Gbeta-gamma. Proceedings of the National Academy of Sciences of the United States of America. 93: 2964-8. PMID 8610151 DOI: 10.1073/Pnas.93.7.2964  0.48
1994 Sternweis PC, Smrcka AV. G proteins in signal transduction: the regulation of phospholipase C. Ciba Foundation Symposium. 176: 96-106; discussion 1. PMID 8299429 DOI: 10.1002/9780470514450.ch7  0.64
1994 Pang IH, Smrcka AV, Sternweis PC. Synthesis and applications of affinity matrix containing immobilized beta gamma subunits of G proteins. Methods in Enzymology. 237: 164-74. PMID 7934994 DOI: 10.1016/S0076-6879(94)37060-5  0.44
1993 Kozasa T, Hepler JR, Smrcka AV, Simon MI, Rhee SG, Sternweis PC, Gilman AG. Purification and characterization of recombinant G16 alpha from Sf9 cells: activation of purified phospholipase C isozymes by G-protein alpha subunits. Proceedings of the National Academy of Sciences of the United States of America. 90: 9176-80. PMID 8415674 DOI: 10.1073/Pnas.90.19.9176  0.68
1993 Sternweis PC, Smrcka AV. Regulation of phospholipase C by G proteins. Trends in Biochemical Sciences. 17: 502-6. PMID 1335185 DOI: 10.1016/0968-0004(92)90340-F  0.8
1992 Sternweis PC, Smrcka AV, Gutowski S. Hormone signalling via G-protein: regulation of phosphatidylinositol 4,5-bisphosphate hydrolysis by Gq. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 336: 35-41; discussion 41. PMID 1351294 DOI: 10.1098/Rstb.1992.0041  0.64
1991 Smrcka AV, Ramage RT, Bohnert HJ, Jensen RG. Purification and characterization of large and small subunits of ribulose 1,5-bisphosphate carboxylase expressed separately in Escherichia coli. Archives of Biochemistry and Biophysics. 286: 6-13. PMID 1910289 DOI: 10.1016/0003-9861(91)90002-Z  0.68
1991 Smrcka AV, Bohnert HJ, Jensen RG. Modulation of the tight binding of carboxyarabinitol 1,5-bisphosphate to the large subunit of ribulose 1,5-bisphosphate carboxylase/oxygenase. Archives of Biochemistry and Biophysics. 286: 14-9. PMID 1910281 DOI: 10.1016/0003-9861(91)90003-2  0.68
1991 Smrcka AV, Hepler JR, Brown KO, Sternweis PC. Regulation of polyphosphoinositide-specific phospholipase C activity by purified Gq. Science (New York, N.Y.). 251: 804-7. PMID 1846707 DOI: 10.1126/Science.1846707  0.68
1988 Smrcka AV, Jensen RG. HPLC separation and indirect ultraviolet detection of phosphorylated sugars. Plant Physiology. 86: 615-8. PMID 16665955 DOI: 10.1104/Pp.86.2.615  1
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