Cynthia V. Stauffacher - Publications

Purdue University, West Lafayette, IN, United States 
General Biophysics, Biochemistry

64 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Quinn TR, Steussy CN, Haines BE, Lei J, Wang W, Sheong FK, Stauffacher CV, Huang X, Norrby PO, Helquist P, Wiest O. Microsecond timescale MD simulations at the transition state of HMGR predict remote allosteric residues. Chemical Science. 12: 6413-6418. PMID 34084441 DOI: 10.1039/d1sc00102g  0.56
2020 Chen CL, Paul LN, Mermoud JC, Steussy CN, Stauffacher CV. Visualizing the enzyme mechanism of mevalonate diphosphate decarboxylase. Nature Communications. 11: 3969. PMID 32769976 DOI: 10.1038/S41467-020-17733-0  0.56
2017 Chen CL, Mermoud JC, Paul LN, Steussy CN, Stauffacher CV. Mevalonate 5-diphosphate mediates ATP binding to the mevalonate diphosphate decarboxylase from the bacterial pathogen Enterococcus faecalis. The Journal of Biological Chemistry. PMID 29025876 DOI: 10.1074/Jbc.M117.802223  0.56
2016 Rushton PS, Olek AT, Makowski L, Badger J, Steussy CN, Carpita NC, Stauffacher CV. Rice Cellulose SynthaseA8 Plant-Conserved Region is a coiled-coil at the catalytic core entrance. Plant Physiology. PMID 27879387 DOI: 10.1104/Pp.16.00739  0.56
2015 Ahi YS, Vemula SV, Hassan AO, Costakes G, Stauffacher C, Mittal SK. Adenoviral L4 33K forms ring-like oligomers and stimulates ATPase activity of IVa2: implications in viral genome packaging. Frontiers in Microbiology. 6: 318. PMID 25954255 DOI: 10.3389/Fmicb.2015.00318  0.72
2015 Clifton MC, Simon MJ, Erramilli SK, Zhang H, Zaitseva J, Hermodson MA, Stauffacher CV. In vitro reassembly of the ribose ATP-binding cassette transporter reveals a distinct set of transport complexes. The Journal of Biological Chemistry. 290: 5555-65. PMID 25533465 DOI: 10.1074/Jbc.M114.621573  0.72
2013 Bourbon P, Peng Q, Ferraudi G, Stauffacher C, Wiest O, Helquist P. Development of carbamate-tethered coumarins as phototriggers for caged nicotinamide. Bioorganic & Medicinal Chemistry Letters. 23: 6321-4. PMID 24125882 DOI: 10.1016/J.Bmcl.2013.09.067  0.72
2013 Haines BE, Wiest O, Stauffacher CV. The increasingly complex mechanism of HMG-CoA reductase. Accounts of Chemical Research. 46: 2416-26. PMID 23898905 DOI: 10.1021/Ar3003267  0.72
2013 Steussy CN, Critchelow CJ, Schmidt T, Min JK, Wrensford LV, Burgner JW, Rodwell VW, Stauffacher CV. A novel role for coenzyme A during hydride transfer in 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Biochemistry. 52: 5195-205. PMID 23802607 DOI: 10.1021/Bi400335G  0.72
2013 Costakes GT, Sen A, Aguilar RC, Stauffacher CV. Crystallographic analysis of the ENTH domain from yeast epsin Ent2 that induces a cell division phenotype. Protein Science : a Publication of the Protein Society. 22: 755-61. PMID 23553749 DOI: 10.1002/Pro.2259  0.72
2013 Bourbon P, Peng Q, Ferraudi G, Stauffacher C, Wiest O, Helquist P. Synthesis and photochemical behavior of coumarin-caged cholesterol. Bioorganic & Medicinal Chemistry Letters. 23: 2162-5. PMID 23434228 DOI: 10.1016/J.Bmcl.2013.01.095  0.72
2012 Haines BE, Steussy CN, Stauffacher CV, Wiest O. Molecular modeling of the reaction pathway and hydride transfer reactions of HMG-CoA reductase. Biochemistry. 51: 7983-95. PMID 22971202 DOI: 10.1021/Bi3008593  0.72
2012 Bourbon P, Peng Q, Ferraudi G, Stauffacher C, Wiest O, Helquist P. Synthesis, photophysical, photochemical, and computational studies of coumarin-labeled nicotinamide derivatives. The Journal of Organic Chemistry. 77: 2756-62. PMID 22360284 DOI: 10.1021/Jo2025527  0.72
2011 Balasubramaniam D, Paul LN, Homan KT, Hall MC, Stauffacher CV. Specificity of HCPTP variants toward EphA2 tyrosines by quantitative selected reaction monitoring. Protein Science : a Publication of the Protein Society. 20: 1172-81. PMID 21538645 DOI: 10.1002/Pro.646  0.72
2010 Balasubramaniam D, Eissler CL, Stauffacher CV, Hall MC. Use of selected reaction monitoring data for label-free quantification of protein modification stoichiometry. Proteomics. 10: 4301-5. PMID 21046619 DOI: 10.1002/Pmic.201000232  0.72
2010 Homan KT, Balasubramaniam D, Zabell APR, Wiest O, Helquist P, Stauffacher CV. Identification of novel inhibitors for a low molecular weight protein tyrosine phosphatase via virtual screening Bioorganic and Medicinal Chemistry. 18: 5449-5456. PMID 20538467 DOI: 10.1016/J.Bmc.2010.04.050  0.72
2006 Steussy CN, Robison AD, Tetrick AM, Knight JT, Rodwell VW, Stauffacher CV, Sutherlin AL. A structural limitation on enzyme activity: the case of HMG-CoA synthase. Biochemistry. 45: 14407-14. PMID 17128980 DOI: 10.1021/Bi061505Q  0.72
2006 Zabell KM, Laurence JS, Kinch MS, Knapp DW, Stauffacher CV. Expression and purification of the intact cytoplasmic domain of the human ephrin receptor A2 tyrosine kinase in Escherichia coli. Protein Expression and Purification. 47: 210-6. PMID 16426859 DOI: 10.1016/J.Pep.2005.10.031  0.72
2006 Zabell AP, Schroff AD, Bain BE, Van Etten RL, Wiest O, Stauffacher CV. Crystal structure of the human B-form low molecular weight phosphotyrosyl phosphatase at 1.6-A resolution. The Journal of Biological Chemistry. 281: 6520-7. PMID 16253994 DOI: 10.1074/Jbc.M506285200  0.72
2006 Weitgenant JA, Katsuyama I, Bigi MA, Corden SJ, Markiewicz JT, Zabell APR, Homan KT, Wiest O, Stauffacher CV, Helquist P. Synthesis of a 5-azaindole phosphonic acid as a computationally designed inhibitor of the low molecular weight phosphatase HCPTP Heterocycles. 70: 599-607. DOI: 10.3987/Com-06-S(W)38  0.72
2005 Steussy CN, Vartia AA, Burgner JW, Sutherlin A, Rodwell VW, Stauffacher CV. X-ray crystal structures of HMG-CoA synthase from Enterococcus faecalis and a complex with its second substrate/inhibitor acetoacetyl-CoA. Biochemistry. 44: 14256-67. PMID 16245942 DOI: 10.1021/Bi051487X  0.72
2005 Gustafson CL, Stauffacher CV, Hallenga K, Van Etten RL. Solution structure of the low-molecular-weight protein tyrosine phosphatase from Tritrichomonas foetus reveals a flexible phosphate binding loop. Protein Science : a Publication of the Protein Society. 14: 2515-25. PMID 16195543 DOI: 10.1110/Ps.051618805  0.72
2004 Laurence JS, Hallenga K, Stauffacher CV. 1H, 15N, 13C resonance assignments of the human protein tyrosine phosphatase PRL-1. Journal of Biomolecular Nmr. 29: 417-8. PMID 15213447 DOI: 10.1023/B:Jnmr.0000032506.16792.C6  0.72
2004 Zabell APR, Corden S, Helquist P, Stauffacher CV, Wiest O. Inhibition studies with rationally designed inhibitors of the human low molecular weight protein tyrosine phosphatase Bioorganic and Medicinal Chemistry. 12: 1867-1880. PMID 15051056 DOI: 10.1016/J.Bmc.2004.01.042  0.72
2004 Hedl M, Tabernero L, Stauffacher CV, Rodwell VW. Class II 3-hydroxy-3-methylglutaryl coenzyme A reductases. Journal of Bacteriology. 186: 1927-32. PMID 15028676 DOI: 10.1128/Jb.186.7.1927-1932.2004  0.72
2003 Tabernero L, Rodwell VW, Stauffacher CV. Crystal structure of a statin bound to a class II hydroxymethylglutaryl-CoA reductase. The Journal of Biological Chemistry. 278: 19933-8. PMID 12621048 DOI: 10.1074/Jbc.M213006200  0.72
2002 Sutherlin A, Hedl M, Sanchez-Neri B, Burgner JW, Stauffacher CV, Rodwell VW. Enterococcus faecalis 3-hydroxy-3-methylglutaryl coenzyme A synthase, an enzyme of isopentenyl diphosphate biosynthesis. Journal of Bacteriology. 184: 4065-70. PMID 12107122 DOI: 10.1128/Jb.184.15.4065-4070.2002  0.72
2002 Chi YI, Sadler I, Jablonski LM, Callantine SD, Deobald CF, Stauffacher CV, Bohach GA. Zinc-mediated dimerization and its effect on activity and conformation of staphylococcal enterotoxin type C. The Journal of Biological Chemistry. 277: 22839-46. PMID 11934896 DOI: 10.1074/Jbc.M201932200  0.72
2002 Hedl M, Sutherlin A, Wilding EI, Mazzulla M, McDevitt D, Lane P, Burgner JW, Lehnbeuter KR, Stauffacher CV, Gwynn MN, Rodwell VW. Enterococcus faecalis acetoacetyl-coenzyme A thiolase/3-hydroxy-3-methylglutaryl-coenzyme A reductase, a dual-function protein of isopentenyl diphosphate biosynthesis. Journal of Bacteriology. 184: 2116-22. PMID 11914342 DOI: 10.1128/Jb.184.8.2116-2122.2002  0.72
2000 Wilding EI, Kim DY, Bryant AP, Gwynn MN, Lunsford RD, McDevitt D, Myers JE, Rosenberg M, Sylvester D, Stauffacher CV, Rodwell VW. Essentiality, expression, and characterization of the class II 3-hydroxy-3-methylglutaryl coenzyme A reductase of Staphylococcus aureus. Journal of Bacteriology. 182: 5147-52. PMID 10960099 DOI: 10.1128/Jb.182.18.5147-5152.2000  0.72
2000 Kim DY, Stauffacher CV, Rodwell VW. Dual coenzyme specificity of Archaeoglobus fulgidus HMG-CoA reductase. Protein Science : a Publication of the Protein Society. 9: 1226-34. PMID 10892815 DOI: 10.1110/Ps.9.6.1226  0.72
2000 Kim DY, Stauffacher CV, Rodwell VW. Engineering of Sulfolobus solfataricus HMG-CoA reductase to a form whose activity is regulated by phosphorylation and dephosphorylation. Biochemistry. 39: 2269-75. PMID 10694393 DOI: 10.1021/Bi991749T  0.72
2000 Wang S, Tabernero L, Zhang M, Harms E, Van Etten RL, Stauffacher CV. Crystal structures of a low-molecular weight protein tyrosine phosphatase from Saccharomyces cerevisiae and its complex with the substrate p-nitrophenyl phosphate Biochemistry. 39: 1903-1914. PMID 10684639 DOI: 10.1021/Bi991348D  0.72
2000 Wang S, Stauffacher CV, Van Etten RL. Structural and mechanistic basis for the activation of a low-molecular weight protein tyro sine phosphatase by adenine Biochemistry. 39: 1234-1242. PMID 10684601 DOI: 10.1021/Bi991515+  0.72
1999 Bochar DA, Stauffacher CV, Rodwell VW. Investigation of the conserved lysines of Syrian hamster 3-hydroxy-3- methylglutaryl coenzyme A reductase Biochemistry. 38: 15848-15852. PMID 10625449 DOI: 10.1021/Bi9914311  0.72
1999 Kim DY, Bochar DA, Stauffacher CV, Rodwell VW. Expression and characterization of the HMG-CoA reductase of the thermophilic archaeon Sulfolobus solfataricus. Protein Expression and Purification. 17: 435-42. PMID 10600463 DOI: 10.1006/Prep.1999.1147  0.72
1999 Tabernero L, Evans BN, Tishmack PA, Van Etten RL, Stauffacher CV. The structure of the bovine protein tyrosine phosphatase dimer reveals a potential self-regulation mechanism. Biochemistry. 38: 11651-8. PMID 10512620 DOI: 10.1021/Bi990381X  0.72
1999 Bochar DA, Tabernero L, Stauffacher CV, Rodwell VW. Aminoethylcysteine can replace the function of the essential active site lysine of Pseudomonas mevalonii 3-hydroxy-3-methylglutaryl coenzyme A reductase Biochemistry. 38: 8879-8883. PMID 10413460 DOI: 10.1021/Bi9902687  0.72
1999 Tabernero L, Bochar DA, Rodwell VW, Stauffacher CV. Substrate-induced closure of the flap domain in the ternary complex structures provides insights into the mechanism of catalysis by 3-hydroxy-3- methylglutaryl-CoA reductase Proceedings of the National Academy of Sciences of the United States of America. 96: 7167-7171. PMID 10377386 DOI: 10.1073/Pnas.96.13.7167  0.72
1999 Bochar DA, Stauffacher CV, Rodwell VW. Sequence comparisons reveal two classes of 3-hydroxy-3- methylglutaryl coenzyme A reductase Molecular Genetics and Metabolism. 66: 122-127. PMID 10068515 DOI: 10.1006/Mgme.1998.2786  0.72
1998 Zhang M, Stauffacher CV, Lin D, Van Etten RL. Crystal structure of a human low molecular weight phosphotyrosyl phosphatase. Implications for substrate specificity. The Journal of Biological Chemistry. 273: 21714-20. PMID 9705307 DOI: 10.1074/Jbc.273.34.21714  0.72
1997 Deringer JR, Ely RJ, Monday SR, Stauffacher CV, Bohach GA. Vbeta-dependent stimulation of bovine and human T cells by host-specific staphylococcal enterotoxins. Infection and Immunity. 65: 4048-54. PMID 9317006 DOI: 10.1128/Iai.65.10.4048-4054.1997  0.72
1997 Bochar DA, Brown JR, Doolittle WF, Klenk HP, Lam W, Schenk ME, Stauffacher CV, Rodwell VW. 3-hydroxy-3-methylglutaryl coenzyme A reductase of Sulfolobus solfataricus: DNA sequence, phylogeny, expression in Escherichia coli of the hmgA gene, and purification and kinetic characterization of the gene product. Journal of Bacteriology. 179: 3632-8. PMID 9171410 DOI: 10.1128/Jb.179.11.3632-3638.1997  0.72
1997 Edwards VM, Deringer JR, Callantine SD, Deobald CF, Berger PH, Kapur V, Stauffacher CV, Bohach GA. Characterization of the canine type c enterotoxin produced by Staphylococcus intermedius pyoderma isolates Infection and Immunity. 65: 2346-2352. PMID 9169773 DOI: 10.1128/Iai.65.6.2346-2352.1997  0.72
1997 Elkins P, Bunker A, Cramer WA, Stauffacher CV. A mechanism for toxin insertion into membranes is suggested by the crystal structure of the channel-forming domain of colicin E1 Structure. 5: 443-458. PMID 9083117 DOI: 10.1016/S0969-2126(97)00200-1  0.72
1997 Zhang M, Zhou M, Van Etten RL, Stauffacher CV. Crystal structure of bovine low molecular weight phosphotyrosyl phosphatase complexed with the transition state analog vanadate Biochemistry. 36: 15-23. PMID 8993313 DOI: 10.1021/Bi961804N  0.72
1996 Deringer JR, Ely RJ, Stauffacher CV, Bohach GA. Subtype-specific interactions of type C staphylococcal enterotoxins with the T-cell receptor. Molecular Microbiology. 22: 523-34. PMID 8939435 DOI: 10.1046/J.1365-2958.1996.1381506.X  0.72
1996 Fields BA, Malchiodi EL, Li H, Ysern X, Stauffacher CV, Schlievert PM, Karjalainen K, Mariuzza RA. Crystal structure of a T-cell receptor β-chain complexed with a superantigen Nature. 384: 188-192. PMID 8906797 DOI: 10.1038/384188A0  0.72
1996 Friesen JA, Lawrence CM, Stauffacher CV, Rodwell VW. Structural determinants of nucleotide coenzyme specificity in the distinctive dinucleotide binding fold of HMG-CoA reductase from Pseudomonas mevalonii. Biochemistry. 35: 11945-50. PMID 8810898 DOI: 10.1021/bi9609937  0.72
1996 Bohach GA, Stauffacher CV, Ohlendorf DH, Chi YI, Vath GM, Schlievert PM. The staphylococcal and streptococcal pyrogenic toxin family Advances in Experimental Medicine and Biology. 391: 131-154. PMID 8726053 DOI: 10.1007/978-1-4613-0361-9_8  0.72
1995 Schlievert PM, Bohach GA, Ohlendorf DH, Stauffacher CV, Leung DY, Murray DL, Prasad GS, Earhart CA, Jablonski LM, Hoffmann ML, Chi YI. Molecular structure of staphylococcus and streptococcus superantigens. Journal of Clinical Immunology. 15: 4S-10S. PMID 8613491 DOI: 10.1007/Bf01540887  0.72
1995 Lawrence CM, Rodwell VW, Stauffacher CV. Crystal structure of Pseudomonas mevalonii HMG-CoA reductase at 3.0 angstrom resolution Science. 268: 1758-1762. PMID 7792601 DOI: 10.1126/Science.7792601  0.72
1995 Cramer WA, Heymann JB, Schendel SL, Deriy BN, Cohen FS, Elkins PA, Stauffacher CV. Structure-function of the channel-forming colicins. Annual Review of Biophysics and Biomolecular Structure. 24: 611-41. PMID 7545041 DOI: 10.1146/Annurev.Bb.24.060195.003143  0.72
1995 Lawrence CM, Chi Young-In, Rodwell VW, Stauffacher CV. Crystallization of HMG-CoA reductase from Pseudomonas mevalonii Acta Crystallographica - Section D Biological Crystallography. 51: 386-389. DOI: 10.1107/S0907444994009819  0.72
1994 Zhang M, Van Etten RL, Lawrence CM, Stauffacher CV. Crystallization and preliminary X-ray analysis of the low molecular weight phosphotyrosyl protein phosphatase from bovine heart Journal of Molecular Biology. 238: 281-283. PMID 8158654 DOI: 10.1006/Jmbi.1994.1287  0.72
1994 Jardetzky TS, Brown JH, Gorga JC, Stern LJ, Urban RG, Chi YI, Stauffacher C, Strominger JL, Wiley DC. Three-dimensional structure of a human class II histocompatibility molecule complexed with superantigen. Nature. 368: 711-8. PMID 8152483 DOI: 10.1038/368711A0  0.72
1994 Elkins PA, Ho Yeong Song, Cramer WA, Stauffacher CV. Crystallization and characterization of colicin E1 channel-forming polypeptides Proteins: Structure, Function and Genetics. 19: 150-157. PMID 8090709 DOI: 10.1002/Prot.340190208  0.72
1994 Hoffmann ML, Jablonski LM, Crum KK, Hackett SP, Chi YI, Stauffacher CV, Stevens DL, Bohach GA. Predictions of T-cell receptor- and major histocompatibility complex-binding sites on staphylococcal enterotoxin C1. Infection and Immunity. 62: 3396-407. PMID 8039910 DOI: 10.1128/Iai.62.8.3396-3407.1994  0.72
1994 Hovde CJ, Marr JC, Hoffmann ML, Hackett SP, Chi YI, Crum KK, Stevens DL, Stauffacher CV, Bohach GA. Investigation of the role of the disulphide bond in the activity and structure of staphylococcal enterotoxin C1. Molecular Microbiology. 13: 897-909. PMID 7815947 DOI: 10.1111/J.1365-2958.1994.Tb00481.X  0.72
1994 Zhang M, Van Etten RL, Stauffacher CV. Crystal structure of bovine heart phosphotyrosyl phosphatase at 2.2-Å resolution Biochemistry. 33: 11097-11105. PMID 7537084 DOI: 10.1021/Bi00203A006  0.72
1992 Bohach GA, Chi YI, Stauffacher CV. Crystallization and preliminary X-ray diffraction analysis of staphylococcal enterotoxin Type C Proteins: Structure, Function and Genetics. 13: 152-157. PMID 1620697 DOI: 10.1002/Prot.340130208  0.72
1992 Cramer WA, Zhang YL, Schendel S, Merrill AR, Song HY, Stauffacher CV, Cohen FS. Dynamic properties of the colicin E1 ion channel. Fems Microbiology Immunology. 5: 71-81. PMID 1384599 DOI: 10.1111/J.1574-6968.1992.Tb05889.X  0.72
1985 Weisel JW, Stauffacher CV, Bullitt E, Cohen C. A model for fibrinogen: domains and sequence. Science (New York, N.Y.). 230: 1388-91. PMID 4071058 DOI: 10.1126/Science.4071058  0.4
1983 Cohen C, Weisel JW, Phillips GN, Stauffacher CV, Fillers JP, Daub E. The structure of fibrinogen and fibrin: I. Electron microscopy and X-ray crystallography of fibrinogen. Annals of the New York Academy of Sciences. 408: 194-213. PMID 6575684 DOI: 10.1111/J.1749-6632.1983.Tb23245.X  0.88
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