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William C. Sessa - Publications

Affiliations: 
Yale University, New Haven, CT 
Area:
Vascular Biology
Website:
http://medicine.yale.edu/pharm/people/william_sessa.profile

296 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Boutagy NE, Gamez-Mendez A, Fowler JW, Zhang H, Chaube BK, Esplugues E, Lee S, Horikami D, Zhang J, Citrin KM, Singh AK, Coon BG, Suarez Y, Fernandez-Hernando C, Sessa WC. Dynamic metabolism of endothelial triglycerides protects against atherosclerosis in mice. The Journal of Clinical Investigation. PMID 38175710 DOI: 10.1172/JCI170453  0.355
2023 Nguyen TD, Rahman NT, Sessa WC, Lee MY. Endothelial nitric oxide synthase (eNOS) S1176 phosphorylation status governs atherosclerotic lesion formation. Frontiers in Cardiovascular Medicine. 10: 1279868. PMID 38034389 DOI: 10.3389/fcvm.2023.1279868  0.385
2021 Ribera J, Portolés I, Córdoba-Jover B, Rodríguez-Vita J, Casals G, González-de la Presa B, Graupera M, Solsona-Vilarrasa E, Garcia-Ruiz C, Fernández-Checa JC, Soria G, Tudela R, Esteve-Codina A, Espadas G, Sabidó E, ... ... Sessa WC, et al. The loss of DHX15 impairs endothelial energy metabolism, lymphatic drainage and tumor metastasis in mice. Communications Biology. 4: 1192. PMID 34654883 DOI: 10.1038/s42003-021-02722-w  0.36
2021 Park H, Furtado J, Poulet M, Chung M, Yun S, Lee S, Sessa WC, Franco CA, Schwartz MA, Eichmann A. Defective Flow-Migration Coupling Causes Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia. Circulation. PMID 34182767 DOI: 10.1161/CIRCULATIONAHA.120.053047  0.338
2021 Bernatchez PN, Tao B, Bradshaw RA, Eveleth D, Sessa WC. Characterization of a Novel Caveolin Modulator That Reduces Vascular Permeability and Ocular Inflammation. Translational Vision Science & Technology. 10: 21. PMID 34111267 DOI: 10.1167/tvst.10.6.21  0.303
2021 Ninchoji T, Love DT, Smith RO, Hedlund M, Vestweber D, Sessa WC, Claesson-Welsh L. eNOS-induced vascular barrier disruption in retinopathy by c-Src activation and tyrosine phosphorylation of VE-cadherin. Elife. 10. PMID 33908348 DOI: 10.7554/eLife.64944  0.338
2020 Tao B, Kraehling JR, Ghaffari S, Ramirez CM, Lee S, Fowler JW, Lee WL, Fernandez-Hernando C, Eichmann A, Sessa WC. BMP-9 and LDL crosstalk regulates ALK-1 endocytosis and LDL transcytosis in endothelial cells. The Journal of Biological Chemistry. 295: 18179-18188. PMID 33453825 DOI: 10.1074/jbc.RA120.015680  0.346
2020 Tao B, Kraehling JR, Ghaffari S, Ramirez CM, Lee S, Fowler JW, Lee WL, Fernandez-Hernando C, Eichmann A, Sessa WC. BMP-9 and LDL crosstalk regulates ALK-1 endocytosis and LDL transcytosis in endothelial cells. The Journal of Biological Chemistry. PMID 33097593 DOI: 10.1074/jbc.RA120.015680  0.348
2020 Boutagy NE, Fowler JW, Sessa WC. A Vectorial, ER-Mitochondria Link to Energy Homeostasis in the Vascular Endothelium. Cell Metabolism. 32: 150-152. PMID 32755606 DOI: 10.1016/J.Cmet.2020.07.010  0.333
2020 Zhang X, Ramírez CM, Aryal B, Madrigal-Matute J, Liu X, Diaz A, Torrecilla-Parra M, Suárez Y, Cuervo AM, Sessa WC, Fernández-Hernando C. Cav-1 (Caveolin-1) Deficiency Increases Autophagy in the Endothelium and Attenuates Vascular Inflammation and Atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology. ATVBAHA120314291. PMID 32349535 DOI: 10.1161/Atvbaha.120.314291  0.433
2020 Garcia V, Park EJ, Siragusa M, Frohlich F, Haque MM, Pascale JV, Heberlein KR, Isakson BE, Stuehr DJ, Sessa WC. Unbiased proteomics identifies plasminogen activator inhibitor-1 as a negative regulator of endothelial nitric oxide synthase. Proceedings of the National Academy of Sciences of the United States of America. PMID 32300005 DOI: 10.1073/Pnas.1918761117  0.49
2020 Zhou H, Mehta S, Srivastava SP, Grabinska K, Zhang X, Wong C, Hedayat A, Perrotta P, Fernández-Hernando C, Sessa WC, Goodwin JE. Endothelial cell-glucocorticoid receptor interactions and regulation of Wnt signaling. Jci Insight. 5. PMID 32051336 DOI: 10.1172/Jci.Insight.131384  0.442
2019 Looft-Wilson RC, Billig JE, Sessa WC. Shear Stress Attenuates Inward Remodeling in Cultured Mouse Thoracodorsal Arteries in an eNOS-Dependent, but Not Hemodynamic Manner, and Increases Cx37 Expression. Journal of Vascular Research. 1-12. PMID 31574503 DOI: 10.1159/000502690  0.321
2019 RamÍrez CM, Zhang X, Bandyopadhyay C, Rotllan N, Sugiyama MG, Aryal B, Liu X, He S, Kraehling JR, Ulrich V, Lin CS, Velazquez H, Lasunción MA, Li G, Suárez Y, ... ... Sessa WC, et al. Caveolin-1 Regulates Atherogenesis by Attenuating LDL Transcytosis and Vascular Inflammation Independent of Endothelial Nitric Oxide Synthase Activation. Circulation. PMID 31154825 DOI: 10.1161/Circulationaha.118.038571  0.461
2019 Hashimoto T, Isaji T, Hu H, Yamamoto K, Bai H, Santana JM, Kuo A, Kuwahara G, Foster TR, Hanisch JJ, Yatsula BA, Sessa WC, Hoshina K, Dardik A. Stimulation of Caveolin-1 Signaling Improves Arteriovenous Fistula Patency. Arteriosclerosis, Thrombosis, and Vascular Biology. ATVBAHA119312417. PMID 30786746 DOI: 10.1161/Atvbaha.119.312417  0.419
2018 Garcia V, Sessa WC. Endothelial Nitric Oxide Synthase (eNOS): Perspective and Recent Developments. British Journal of Pharmacology. PMID 30341769 DOI: 10.1111/Bph.14522  0.482
2018 Zhang X, Sessa WC, Fernández-Hernando C. Endothelial Transcytosis of Lipoproteins in Atherosclerosis. Frontiers in Cardiovascular Medicine. 5: 130. PMID 30320124 DOI: 10.3389/Fcvm.2018.00130  0.383
2018 Zhang F, Zarkada G, Han J, Li J, Dubrac A, Ola R, Genet G, Boyé K, Michon P, Künzel SE, Camporez JP, Singh AK, Fong GH, Simons M, Tso P, ... ... Sessa WC, et al. Lacteal junction zippering protects against diet-induced obesity. Science (New York, N.Y.). 361: 599-603. PMID 30093598 DOI: 10.1126/Science.Aap9331  0.386
2018 Ola R, Künzel SH, Zhang F, Genet G, Chakraborty R, Pibouin-Fragner L, Martin K, Sessa W, Dubrac A, Eichmann A. SMAD4 Prevents Flow Induced Arterial-Venous Malformations by Inhibiting Casein Kinase 2. Circulation. PMID 29976569 DOI: 10.1161/Circulationaha.118.033842  0.457
2018 Luciano AK, Zhou W, Santana JM, Kyriakides C, Velazquez H, Sessa WC. CLOCK phosphorylation by AKT regulates its nuclear accumulation and circadian gene expression in peripheral tissues. The Journal of Biological Chemistry. PMID 29588368 DOI: 10.1074/Jbc.Ra117.000773  0.304
2018 Lee MY, Gamez-Mendez A, Zhang J, Zhuang Z, Vinyard DJ, Kraehling J, Velazquez H, Brudvig GW, Kyriakides TR, Simons M, Sessa WC. Endothelial Cell Autonomous Role of Akt1: Regulation of Vascular Tone and Ischemia-Induced Arteriogenesis. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 29449333 DOI: 10.1161/Atvbaha.118.310748  0.477
2017 Kuo A, Lee MY, Yang K, Gross RW, Sessa WC. Caveolin-1 regulates lipid droplet metabolism in endothelial cells via autocrine prostacyclin stimulated cAMP-mediated lipolysis. The Journal of Biological Chemistry. PMID 29203526 DOI: 10.1074/Jbc.Ra117.000980  0.413
2017 Protack CD, Foster TR, Hashimoto T, Yamamoto K, Lee MY, Kraehling JR, Bai H, Hu H, Isaji T, Santana JM, Wang M, Sessa WC, Dardik A. Eph-B4 regulates adaptive venous remodeling to improve arteriovenous fistula patency. Scientific Reports. 7: 15386. PMID 29133876 DOI: 10.1038/S41598-017-13071-2  0.373
2017 Jin Y, Xie Y, Ostriker AC, Zhang X, Liu R, Lee MY, Leslie KL, Tang W, Du J, Lee SH, Wang Y, Sessa WC, Hwa J, Yu J, Martin KA. Opposing Actions of AKT (Protein Kinase B) Isoforms in Vascular Smooth Muscle Injury and Therapeutic Response. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 29025710 DOI: 10.1161/Atvbaha.117.310053  0.427
2017 Jiang Y, Lin X, Tang Z, Lee C, Tian G, Du Y, Yin X, Ren X, Huang L, Ye Z, Chen W, Zhang F, Mi J, Gao Z, Wang S, ... ... Sessa WC, et al. Critical role of caveolin-1 in ocular neovascularization and multitargeted antiangiogenic effects of cavtratin via JNK. Proceedings of the National Academy of Sciences of the United States of America. PMID 28923916 DOI: 10.1073/Pnas.1706394114  0.468
2017 MacLauchlan SC, Calabro NE, Huang Y, Krishna M, Bancroft T, Sharma T, Yu J, Sessa WC, Giordano F, Kyriakides TR. HIF-1α represses the expression of the angiogenesis inhibitor thrombospondin-2. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 28789925 DOI: 10.1016/J.Matbio.2017.07.002  0.353
2017 Luciano AK, Santana JM, Velazquez H, Sessa WC. Akt1 Controls the Timing and Amplitude of Vascular Circadian Gene Expression. Journal of Biological Rhythms. 748730417704534. PMID 28452287 DOI: 10.1177/0748730417704534  0.369
2017 Kraehling JR, Sessa WC. Contemporary Approaches to Modulating the Nitric Oxide-cGMP Pathway in Cardiovascular Disease. Circulation Research. 120: 1174-1182. PMID 28360348 DOI: 10.1161/Circresaha.117.303776  0.479
2017 Kuo A, Lee MY, Sessa WC. Lipid Droplet Biogenesis and Function in the Endothelium. Circulation Research. PMID 28119423 DOI: 10.1161/Circresaha.116.310498  0.361
2016 Ola R, Dubrac A, Han J, Zhang F, Fang JS, Larrivée B, Lee M, Urarte AA, Kraehling JR, Genet G, Hirschi KK, Sessa WC, Canals FV, Graupera M, Yan M, et al. PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia. Nature Communications. 7: 13650. PMID 27897192 DOI: 10.1038/Ncomms13650  0.463
2016 Kraehling JR, Chidlow JH, Rajagopal C, Sugiyama MG, Fowler JW, Lee MY, Zhang X, Ramírez CM, Park EJ, Tao B, Chen K, Kuruvilla L, Larriveé B, Folta-Stogniew E, Ola R, ... ... Sessa WC, et al. Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells. Nature Communications. 7: 13516. PMID 27869117 DOI: 10.1038/Ncomms13516  0.411
2016 Park EJ, Grabińska KA, Guan Z, Sessa WC. NgBR is essential for endothelial cell glycosylation and vascular development. Embo Reports. PMID 26755743 DOI: 10.15252/Embr.201540789  0.483
2016 Marin EP, Jozsef L, Di Lorenzo A, Held KF, Luciano AK, Melendez J, Milstone LM, Velazquez H, Sessa WC. The Protein Acyl Transferase ZDHHC21 Modulates α1 Adrenergic Receptor Function and Regulates Hemodynamics. Arteriosclerosis, Thrombosis, and Vascular Biology. 36: 370-9. PMID 26715683 DOI: 10.1161/Atvbaha.115.306942  0.357
2015 Kraehling JR, Hao Z, Lee MY, Vinyard D, Velazquez H, Liu X, Stan RV, Brudvig G, Sessa WC. Uncoupling Caveolae from Intracellular Signaling In Vivo. Circulation Research. PMID 26602865 DOI: 10.1161/Circresaha.115.307767  0.429
2015 Chamorro-Jorganes A, Lee MY, Araldi E, Landskroner-Eiger S, Fernandez-Fuertes M, Sahraei M, Quiles Del Rey M, van Solingen C, Yu J, Fernandez-Hernando C, Sessa WC, Suarez Y. VEGF-Induced Expression of miR-17~92 Cluster in Endothelial Cells is Mediated by ERK/ELK1 Activation and Regulates Angiogenesis. Circulation Research. PMID 26472816 DOI: 10.1161/Circresaha.115.307408  0.409
2015 Landskroner-Eiger S, Qiu C, Perrotta P, Siragusa M, Lee MY, Ulrich V, Luciano AK, Zhuang ZW, Corti F, Simons M, Montgomery RL, Wu D, Yu J, Sessa WC. Endothelial miR-17∼92 cluster negatively regulates arteriogenesis via miRNA-19 repression of WNT signaling. Proceedings of the National Academy of Sciences of the United States of America. PMID 26417068 DOI: 10.1073/Pnas.1507094112  0.316
2015 Siragusa M, Fröhlich F, Park EJ, Schleicher M, Walther TC, Sessa WC. Stromal cell-derived factor 2 is critical for Hsp90-dependent eNOS activation. Science Signaling. 8: ra81. PMID 26286023 DOI: 10.1126/Scisignal.Aaa2819  0.514
2015 Kraehling JR, Sessa WC. Enhanced eNOS Activation as the Fountain of Youth for Vascular Disease: Is BPIFB4 What Ponce de León Was Looking For? Circulation Research. 117: 309-10. PMID 26227874 DOI: 10.1161/Circresaha.115.307020  0.303
2015 Xie Y, Jin Y, Merenick BL, Ding M, Fetalvero KM, Wagner RJ, Mai A, Gleim S, Tucker DF, Birnbaum MJ, Ballif BA, Luciano AK, Sessa WC, Rzucidlo EM, Powell RJ, et al. Phosphorylation of GATA-6 is required for vascular smooth muscle cell differentiation after mTORC1 inhibition. Science Signaling. 8: ra44. PMID 25969542 DOI: 10.1126/Scisignal.2005482  0.444
2015 Rotllan N, Wanschel AC, Fernández-Hernando A, Salerno AG, Offermanns S, Sessa WC, Fernández-Hernando C. Genetic Evidence Supports a Major Role for Akt1 in VSMCs During Atherogenesis. Circulation Research. 116: 1744-52. PMID 25868464 DOI: 10.1161/Circresaha.116.305895  0.435
2015 Goodwin JE, Zhang X, Rotllan N, Feng Y, Zhou H, Fernández-Hernando C, Yu J, Sessa WC. Endothelial glucocorticoid receptor suppresses atherogenesis--brief report. Arteriosclerosis, Thrombosis, and Vascular Biology. 35: 779-82. PMID 25810297 DOI: 10.1161/Atvbaha.114.304525  0.389
2015 Rotllan N, Chamorro-Jorganes A, Araldi E, Wanschel AC, Aryal B, Aranda JF, Goedeke L, Salerno AG, Ramírez CM, Sessa WC, Suárez Y, Fernández-Hernando C. Hematopoietic Akt2 deficiency attenuates the progression of atherosclerosis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 29: 597-610. PMID 25392271 DOI: 10.1096/Fj.14-262097  0.366
2015 Bancroft T, Bouaouina M, Roberts S, Lee M, Calderwood DA, Schwartz M, Simons M, Sessa WC, Kyriakides TR. Up-regulation of thrombospondin-2 in Akt1-null mice contributes to compromised tissue repair due to abnormalities in fibroblast function. The Journal of Biological Chemistry. 290: 409-22. PMID 25389299 DOI: 10.1074/Jbc.M114.618421  0.413
2015 Pober JS, Sessa WC. Inflammation and the blood microvascular system. Cold Spring Harbor Perspectives in Biology. 7: a016345. PMID 25384307 DOI: 10.1101/Cshperspect.A016345  0.376
2014 Goodwin JE, Feng Y, Velazquez H, Zhou H, Sessa WC. Loss of the endothelial glucocorticoid receptor prevents the therapeutic protection afforded by dexamethasone after LPS. Plos One. 9: e108126. PMID 25299055 DOI: 10.1371/Journal.Pone.0108126  0.336
2014 Lee MY, Luciano AK, Ackah E, Rodriguez-Vita J, Bancroft TA, Eichmann A, Simons M, Kyriakides TR, Morales-Ruiz M, Sessa WC. Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates. Proceedings of the National Academy of Sciences of the United States of America. 111: 12865-70. PMID 25136137 DOI: 10.1073/Pnas.1408472111  0.825
2014 Park EJ, Grabi?ska KA, Guan Z, Stránecký V, Hartmannová H, Hoda?ová K, Barešová V, Sovová J, Jozsef L, Ondrušková N, Hansíková H, Honzík T, Zeman J, H?lková H, Wen R, ... ... Sessa WC, et al. Mutation of Nogo-B receptor, a subunit of cis-prenyltransferase, causes a congenital disorder of glycosylation. Cell Metabolism. 20: 448-57. PMID 25066056 DOI: 10.1016/J.Cmet.2014.06.016  0.311
2014 Mehra VC, Jackson E, Zhang XM, Jiang XC, Dobrucki LW, Yu J, Bernatchez P, Sinusas AJ, Shulman GI, Sessa WC, Yarovinsky TO, Bender JR. Ceramide-activated phosphatase mediates fatty acid-induced endothelial VEGF resistance and impaired angiogenesis. The American Journal of Pathology. 184: 1562-76. PMID 24606881 DOI: 10.1016/J.Ajpath.2014.01.009  0.486
2014 Lee MY, Skoura A, Park EJ, Landskroner-Eiger S, Jozsef L, Luciano AK, Murata T, Pasula S, Dong Y, Bouaouina M, Calderwood DA, Ferguson SM, De Camilli P, Sessa WC. Dynamin 2 regulation of integrin endocytosis, but not VEGF signaling, is crucial for developmental angiogenesis. Development (Cambridge, England). 141: 1465-72. PMID 24598168 DOI: 10.1242/Jcs.153080  0.468
2014 Jozsef L, Tashiro K, Kuo A, Park EJ, Skoura A, Albinsson S, Rivera-Molina F, Harrison KD, Iwakiri Y, Toomre D, Sessa WC. Reticulon 4 is necessary for endoplasmic reticulum tubulation, STIM1-Orai1 coupling, and store-operated calcium entry. The Journal of Biological Chemistry. 289: 9380-95. PMID 24558039 DOI: 10.1074/Jbc.M114.548602  0.732
2014 Ju R, Zhuang ZW, Zhang J, Lanahan AA, Kyriakides T, Sessa WC, Simons M. Angiopoietin-2 secretion by endothelial cell exosomes: Regulation by the phosphatidylinositol 3-kinase (PI3K)/Akt/endothelial nitric oxide synthase (eNOS) and syndecan-4/syntenin pathways Journal of Biological Chemistry. 289: 510-519. PMID 24235146 DOI: 10.1074/Jbc.M113.506899  0.516
2013 Kondo Y, Jadlowiec CC, Muto A, Yi T, Protack C, Collins MJ, Tellides G, Sessa WC, Dardik A. The Nogo-B-PirB axis controls macrophage-mediated vascular remodeling. Plos One. 8: e81019. PMID 24278366 DOI: 10.1371/Journal.Pone.0081019  0.447
2013 Di Lorenzo A, Lin MI, Murata T, Landskroner-Eiger S, Schleicher M, Kothiya M, Iwakiri Y, Yu J, Huang PL, Sessa WC. eNOS-derived nitric oxide regulates endothelial barrier function through VE-cadherin and Rho GTPases. Journal of Cell Science. 126: 5541-52. PMID 24046447 DOI: 10.1242/Jcs.115972  0.685
2013 Reese C, Dyer S, Perry B, Bonner M, Oates J, Hofbauer A, Sessa W, Bernatchez P, Visconti RP, Zhang J, Hatfield CM, Silver RM, Hoffman S, Tourkina E. Differential regulation of cell functions by CSD peptide subdomains. Respiratory Research. 14: 90. PMID 24011378 DOI: 10.1186/1465-9921-14-90  0.305
2013 Li Q, Atochin D, Kashiwagi S, Earle J, Wang A, Mandeville E, Hayakawa K, d'Uscio LV, Lo EH, Katusic Z, Sessa W, Huang PL. Deficient eNOS phosphorylation is a mechanism for diabetic vascular dysfunction contributing to increased stroke size. Stroke; a Journal of Cerebral Circulation. 44: 3183-8. PMID 23988642 DOI: 10.1161/Strokeaha.113.002073  0.386
2013 Huang Y, Di Lorenzo A, Jiang W, Cantalupo A, Sessa WC, Giordano FJ. Hypoxia-inducible factor-1α in vascular smooth muscle regulates blood pressure homeostasis through a peroxisome proliferator-activated receptor-γ-angiotensin II receptor type 1 axis. Hypertension. 62: 634-40. PMID 23918749 DOI: 10.1161/Hypertensionaha.111.00160  0.325
2013 Siragusa M, Sessa WC. Telmisartan exerts pleiotropic effects in endothelial cells and promotes endothelial cell quiescence and survival. Arteriosclerosis, Thrombosis, and Vascular Biology. 33: 1852-60. PMID 23702662 DOI: 10.1161/Atvbaha.112.300985  0.434
2013 Li W, Li Q, Qin L, Ali R, Qyang Y, Tassabehji M, Pober BR, Sessa WC, Giordano FJ, Tellides G. Rapamycin inhibits smooth muscle cell proliferation and obstructive arteriopathy attributable to elastin deficiency. Arteriosclerosis, Thrombosis, and Vascular Biology. 33: 1028-35. PMID 23493289 DOI: 10.1161/Atvbaha.112.300407  0.342
2013 Jaba IM, Zhuang ZW, Li N, Jiang Y, Martin KA, Sinusas AJ, Papademetris X, Simons M, Sessa WC, Young LH, Tirziu D. NO triggers RGS4 degradation to coordinate angiogenesis and cardiomyocyte growth. The Journal of Clinical Investigation. 123: 1718-31. PMID 23454748 DOI: 10.1172/Jci65112  0.359
2013 Kashiwagi S, Atochin DN, Li Q, Schleicher M, Pong T, Sessa WC, Huang PL. ENOS phosphorylation on serine 1176 affects insulin sensitivity and adiposity Biochemical and Biophysical Research Communications. 431: 284-290. PMID 23291238 DOI: 10.1016/J.Bbrc.2012.12.110  0.369
2013 Goodwin JE, Feng Y, Velazquez H, Sessa WC. Endothelial glucocorticoid receptor is required for protection against sepsis. Proceedings of the National Academy of Sciences of the United States of America. 110: 306-11. PMID 23248291 DOI: 10.1073/Pnas.1210200110  0.447
2012 Sessa WC. A new approach to weight loss: just activate endothelial NO synthase! Circulation Research. 111: 1111-2. PMID 23065339 DOI: 10.1161/Circresaha.112.279794  0.446
2012 Chick HE, Nowrouzi A, Fronza R, McDonald RA, Kane NM, Alba R, Delles C, Sessa WC, Schmidt M, Thrasher AJ, Baker AH. Integrase-deficient lentiviral vectors mediate efficient gene transfer to human vascular smooth muscle cells with minimal genotoxic risk. Human Gene Therapy. 23: 1247-57. PMID 22931362 DOI: 10.1089/Hum.2012.042  0.345
2012 Zhang P, Huang A, Morales-Ruiz M, Starcher BC, Huang Y, Sessa WC, Niklason LE, Giordano FJ. Engineered zinc-finger proteins can compensate genetic haploinsufficiency by transcriptional activation of the wild-type allele: application to Willams-Beuren syndrome and supravalvular aortic stenosis. Human Gene Therapy. 23: 1186-99. PMID 22891920 DOI: 10.1089/Hum.2011.201  0.337
2012 Marin EP, Derakhshan B, Lam TT, Davalos A, Sessa WC. Endothelial cell palmitoylproteomic identifies novel lipid-modified targets and potential substrates for protein acyl transferases. Circulation Research. 110: 1336-44. PMID 22496122 DOI: 10.1161/Circresaha.112.269514  0.376
2012 Tkachenko E, Tse D, Sideleva O, Deharvengt SJ, Luciano MR, Xu Y, McGarry CL, Chidlow J, Pilch PF, Sessa WC, Toomre DK, Stan RV. Caveolae, fenestrae and transendothelial channels retain PV1 on the surface of endothelial cells. Plos One. 7: e32655. PMID 22403691 DOI: 10.1371/Journal.Pone.0032655  0.369
2012 Sangwung P, Greco TM, Wang Y, Ischiropoulos H, Sessa WC, Iwakiri Y. Proteomic identification of S-nitrosylated Golgi proteins: new insights into endothelial cell regulation by eNOS-derived NO. Plos One. 7: e31564. PMID 22363674 DOI: 10.1371/Journal.Pone.0031564  0.456
2012 Yu J, Zhang Y, Zhang X, Rudic RD, Bauer PM, Altieri DC, Sessa WC. Endothelium derived nitric oxide synthase negatively regulates the PDGF-survivin pathway during flow-dependent vascular remodeling. Plos One. 7: e31495. PMID 22355372 DOI: 10.1371/Journal.Pone.0031495  0.774
2012 Zhang J, Modi Y, Yarovinsky T, Yu J, Collinge M, Kyriakides T, Zhu Y, Sessa WC, Pardi R, Bender JR. Macrophage β2 integrin-mediated, HuR-dependent stabilization of angiogenic factor-encoding mRNAs in inflammatory angiogenesis. The American Journal of Pathology. 180: 1751-60. PMID 22322302 DOI: 10.1016/J.Ajpath.2011.12.025  0.364
2012 Förstermann U, Sessa WC. Nitric oxide synthases: regulation and function. European Heart Journal. 33: 829-37, 837a-837d. PMID 21890489 DOI: 10.1093/Eurheartj/Ehr304  0.459
2012 Collins M, Muto A, Feigel A, Protack C, Jadlowiec C, Sessa W, Dardik A. EphB4 Activates Endothelial Nitric Oxide Synthase in An Akt-dependent Mechanism to Regulate Vein Graft Adaptation Journal of Surgical Research. 172: 267. DOI: 10.1016/J.Jss.2011.11.869  0.453
2011 MacLauchlan S, Yu J, Parrish M, Asoulin TA, Schleicher M, Krady MM, Zeng J, Huang PL, Sessa WC, Kyriakides TR. Endothelial nitric oxide synthase controls the expression of the angiogenesis inhibitor thrombospondin 2. Proceedings of the National Academy of Sciences of the United States of America. 108: E1137-45. PMID 21949402 DOI: 10.1073/Pnas.1104357108  0.494
2011 Bernatchez P, Sharma A, Bauer PM, Marin E, Sessa WC. A noninhibitory mutant of the caveolin-1 scaffolding domain enhances eNOS-derived NO synthesis and vasodilation in mice. The Journal of Clinical Investigation. 121: 3747-55. PMID 21804187 DOI: 10.1172/Jci44778  0.461
2011 Karuppiah K, Druhan LJ, Chen CA, Smith T, Zweier JL, Sessa WC, Cardounel AJ. Suppression of eNOS-derived superoxide by caveolin-1: a biopterin-dependent mechanism. American Journal of Physiology. Heart and Circulatory Physiology. 301: H903-11. PMID 21724868 DOI: 10.1152/Ajpheart.00936.2010  0.476
2011 Sutendra G, Dromparis P, Wright P, Bonnet S, Haromy A, Hao Z, McMurtry MS, Michalak M, Vance JE, Sessa WC, Michelakis ED. The role of Nogo and the mitochondria-endoplasmic reticulum unit in pulmonary hypertension. Science Translational Medicine. 3: 88ra55. PMID 21697531 DOI: 10.1126/Scitranslmed.3002194  0.773
2011 Harrison KD, Park EJ, Gao N, Kuo A, Rush JS, Waechter CJ, Lehrman MA, Sessa WC. Nogo-B receptor is necessary for cellular dolichol biosynthesis and protein N-glycosylation. The Embo Journal. 30: 2490-500. PMID 21572394 DOI: 10.1038/Emboj.2011.147  0.751
2011 Albinsson S, Skoura A, Yu J, DiLorenzo A, Fernández-Hernando C, Offermanns S, Miano JM, Sessa WC. Smooth muscle miRNAs are critical for post-natal regulation of blood pressure and vascular function. Plos One. 6: e18869. PMID 21526127 DOI: 10.1371/Journal.Pone.0018869  0.353
2011 Zhang D, Utsumi T, Huang HC, Gao L, Sangwung P, Chung C, Shibao K, Okamoto K, Yamaguchi K, Groszmann RJ, Jozsef L, Hao Z, Sessa WC, Iwakiri Y. Reticulon 4B (Nogo-B) is a novel regulator of hepatic fibrosis. Hepatology (Baltimore, Md.). 53: 1306-15. PMID 21480333 DOI: 10.1002/Hep.24200  0.338
2011 Muto A, Yi T, Harrison KD, Dávalos A, Fancher TT, Ziegler KR, Feigel A, Kondo Y, Nishibe T, Sessa WC, Dardik A. Eph-B4 prevents venous adaptive remodeling in the adult arterial environment. The Journal of Experimental Medicine. 208: 561-75. PMID 21339325 DOI: 10.1084/Jem.20101854  0.765
2011 Briand N, Le Lay S, Sessa WC, Ferré P, Dugail I. Distinct roles of endothelial and adipocyte caveolin-1 in macrophage infiltration and adipose tissue metabolic activity. Diabetes. 60: 448-53. PMID 21270257 DOI: 10.2337/Db10-0856  0.362
2011 Di Lorenzo A, Manes TD, Davalos A, Wright PL, Sessa WC. Endothelial reticulon-4B (Nogo-B) regulates ICAM-1-mediated leukocyte transmigration and acute inflammation. Blood. 117: 2284-95. PMID 21183689 DOI: 10.1182/Blood-2010-04-281956  0.804
2011 Albinsson S, Sessa WC. Can microRNAs control vascular smooth muscle phenotypic modulation and the response to injury? Physiological Genomics. 43: 529-33. PMID 20841497 DOI: 10.1152/Physiolgenomics.00146.2010  0.301
2010 Wright PL, Yu J, Di YP, Homer RJ, Chupp G, Elias JA, Cohn L, Sessa WC. Epithelial reticulon 4B (Nogo-B) is an endogenous regulator of Th2-driven lung inflammation. The Journal of Experimental Medicine. 207: 2595-607. PMID 20975041 DOI: 10.1084/Jem.20100786  0.752
2010 Marin EP, Moeckel G, Al-Lamki R, Bradley J, Yan Q, Wang T, Wright PL, Yu J, Sessa WC. Identification and regulation of reticulon 4B (Nogo-B) in renal tubular epithelial cells. The American Journal of Pathology. 177: 2765-73. PMID 20971739 DOI: 10.2353/Ajpath.2010.100199  0.76
2010 Terasaka N, Westerterp M, Koetsveld J, Fernández-Hernando C, Yvan-Charvet L, Wang N, Sessa WC, Tall AR. ATP-binding cassette transporter G1 and high-density lipoprotein promote endothelial NO synthesis through a decrease in the interaction of caveolin-1 and endothelial NO synthase. Arteriosclerosis, Thrombosis, and Vascular Biology. 30: 2219-25. PMID 20798376 DOI: 10.1161/Atvbaha.110.213215  0.338
2010 Lazorchak AS, Liu D, Facchinetti V, Di Lorenzo A, Sessa WC, Schatz DG, Su B. Sin1-mTORC2 suppresses rag and il7r gene expression through Akt2 in B cells. Molecular Cell. 39: 433-43. PMID 20705244 DOI: 10.1016/J.Molcel.2010.07.031  0.384
2010 Sessa WC. A new way to lower blood pressure: pass the chili peppers please! Cell Metabolism. 12: 109-10. PMID 20674855 DOI: 10.1016/J.Cmet.2010.07.005  0.315
2010 Zheng X, Xu C, Di Lorenzo A, Kleaveland B, Zou Z, Seiler C, Chen M, Cheng L, Xiao J, He J, Pack MA, Sessa WC, Kahn ML. CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations. The Journal of Clinical Investigation. 120: 2795-804. PMID 20592472 DOI: 10.1172/Jci39679  0.456
2010 Krieger MH, Di Lorenzo A, Teutsch C, Kauser K, Sessa WC. Telmisartan regresses left ventricular hypertrophy in caveolin-1-deficient mice. Laboratory Investigation; a Journal of Technical Methods and Pathology. 90: 1573-81. PMID 20585312 DOI: 10.1038/Labinvest.2010.116  0.302
2010 Dávalos A, Fernández-Hernando C, Sowa G, Derakhshan B, Lin MI, Lee JY, Zhao H, Luo R, Colangelo C, Sessa WC. Quantitative proteomics of caveolin-1-regulated proteins: characterization of polymerase i and transcript release factor/CAVIN-1 IN endothelial cells. Molecular & Cellular Proteomics : McP. 9: 2109-24. PMID 20585024 DOI: 10.1074/Mcp.M110.001289  0.644
2010 Fernández-Hernando C, Yu J, Dávalos A, Prendergast J, Sessa WC. Endothelial-specific overexpression of caveolin-1 accelerates atherosclerosis in apolipoprotein E-deficient mice. The American Journal of Pathology. 177: 998-1003. PMID 20581061 DOI: 10.2353/Ajpath.2010.091287  0.492
2010 Albinsson S, Suarez Y, Skoura A, Offermanns S, Miano JM, Sessa WC. MicroRNAs are necessary for vascular smooth muscle growth, differentiation, and function. Arteriosclerosis, Thrombosis, and Vascular Biology. 30: 1118-26. PMID 20378849 DOI: 10.1161/Atvbaha.109.200873  0.312
2010 Sanchez-Madrid F, Sessa WC. Spotlight on mechanisms of vascular inflammation. Cardiovascular Research. 86: 171-3. PMID 20228399 DOI: 10.1093/Cvr/Cvq083  0.351
2010 Chidlow JH, Sessa WC. Caveolae, caveolins, and cavins: complex control of cellular signalling and inflammation. Cardiovascular Research. 86: 219-25. PMID 20202978 DOI: 10.1093/Cvr/Cvq075  0.372
2010 Muto A, Yi T, Harrison K, Davalos A, Sessa WC, Dardik A. SS6. Venous Specific Eph-B4 Regulates Vein Graft Thickening via Caveolin-1 Journal of Vascular Surgery. 51: 6S-7S. DOI: 10.1016/J.Jvs.2010.02.046  0.756
2009 Yu J, Fernández-Hernando C, Suarez Y, Schleicher M, Hao Z, Wright PL, DiLorenzo A, Kyriakides TR, Sessa WC. Reticulon 4B (Nogo-B) is necessary for macrophage infiltration and tissue repair. Proceedings of the National Academy of Sciences of the United States of America. 106: 17511-6. PMID 19805174 DOI: 10.1073/Pnas.0907359106  0.767
2009 Fernández-Hernando C, József L, Jenkins D, Di Lorenzo A, Sessa WC. Absence of Akt1 reduces vascular smooth muscle cell migration and survival and induces features of plaque vulnerability and cardiac dysfunction during atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology. 29: 2033-40. PMID 19762778 DOI: 10.1161/Atvbaha.109.196394  0.406
2009 Harrison KD, Miao RQ, Fernandez-Hernándo C, Suárez Y, Dávalos A, Sessa WC. Nogo-B receptor stabilizes Niemann-Pick type C2 protein and regulates intracellular cholesterol trafficking. Cell Metabolism. 10: 208-18. PMID 19723497 DOI: 10.1016/J.Cmet.2009.07.003  0.759
2009 Schleicher M, Yu J, Murata T, Derakhshan B, Atochin D, Qian L, Kashiwagi S, Di Lorenzo A, Harrison KD, Huang PL, Sessa WC. The Akt1-eNOS axis illustrates the specificity of kinase-substrate relationships in vivo Science Signaling. 2: ra41. PMID 19654415 DOI: 10.1126/Scisignal.2000343  0.792
2009 Sessa WC. Molecular control of blood flow and angiogenesis: role of nitric oxide. Journal of Thrombosis and Haemostasis : Jth. 35-7. PMID 19630764 DOI: 10.1111/J.1538-7836.2009.03424.X  0.436
2009 Di Lorenzo A, Fernández-Hernando C, Cirino G, Sessa WC. Akt1 is critical for acute inflammation and histamine-mediated vascular leakage. Proceedings of the National Academy of Sciences of the United States of America. 106: 14552-7. PMID 19622728 DOI: 10.1073/Pnas.0904073106  0.467
2009 Fernández-Hernando C, Yu J, Suárez Y, Rahner C, Dávalos A, Lasunción MA, Sessa WC. Genetic evidence supporting a critical role of endothelial caveolin-1 during the progression of atherosclerosis. Cell Metabolism. 10: 48-54. PMID 19583953 DOI: 10.1016/J.Cmet.2009.06.003  0.47
2009 Bernatchez PN, Sharma A, Kodaman P, Sessa WC. Myoferlin is critical for endocytosis in endothelial cells. American Journal of Physiology. Cell Physiology. 297: C484-92. PMID 19494235 DOI: 10.1152/Ajpcell.00498.2008  0.394
2009 Suárez Y, Sessa WC. MicroRNAs as novel regulators of angiogenesis. Circulation Research. 104: 442-54. PMID 19246688 DOI: 10.1161/Circresaha.108.191270  0.382
2009 Chidlow JH, Greer JJ, Anthoni C, Bernatchez P, Fernandez-Hernando C, Fernadez-Hernando C, Bruce M, Abdelbaqi M, Shukla D, Granger DN, Sessa WC, Kevil CG. Endothelial caveolin-1 regulates pathologic angiogenesis in a mouse model of colitis. Gastroenterology. 136: 575-84.e2. PMID 19111727 DOI: 10.1053/J.Gastro.2008.10.085  0.44
2008 Tang PC, Qin L, Zielonka J, Zhou J, Matte-Martone C, Bergaya S, van Rooijen N, Shlomchik WD, Min W, Sessa WC, Pober JS, Tellides G. MyD88-dependent, superoxide-initiated inflammation is necessary for flow-mediated inward remodeling of conduit arteries. The Journal of Experimental Medicine. 205: 3159-71. PMID 19064699 DOI: 10.1084/Jem.20081298  0.425
2008 Murata T, Lin MI, Aritake K, Matsumoto S, Narumiya S, Ozaki H, Urade Y, Hori M, Sessa WC. Role of prostaglandin D2 receptor DP as a suppressor of tumor hyperpermeability and angiogenesis in vivo. Proceedings of the National Academy of Sciences of the United States of America. 105: 20009-14. PMID 19060214 DOI: 10.1073/Pnas.0805171105  0.629
2008 Zhang H, He Y, Dai S, Xu Z, Luo Y, Wan T, Luo D, Jones D, Tang S, Chen H, Sessa WC, Min W. AIP1 functions as an endogenous inhibitor of VEGFR2-mediated signaling and inflammatory angiogenesis in mice. The Journal of Clinical Investigation. 118: 3904-16. PMID 19033661 DOI: 10.1172/Jci36168  0.474
2008 Kritz AB, Yu J, Wright PL, Wan S, George SJ, Halliday C, Kang N, Sessa WC, Baker AH. In vivo modulation of Nogo-B attenuates neointima formation. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 1798-804. PMID 18781142 DOI: 10.1038/Mt.2008.188  0.775
2008 Suárez Y, Fernández-Hernando C, Yu J, Gerber SA, Harrison KD, Pober JS, Iruela-Arispe ML, Merkenschlager M, Sessa WC. Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis. Proceedings of the National Academy of Sciences of the United States of America. 105: 14082-7. PMID 18779589 DOI: 10.1073/Pnas.0804597105  0.77
2008 Derakhshan B, Harrison KD, Miao QR, Sessa WC. Chapter 1 Approaches for Studying Angiogenesis-Related Signal Transduction Methods in Enzymology. 443: 1-23. PMID 18772008 DOI: 10.1016/S0076-6879(08)02001-6  0.798
2008 Krady MM, Zeng J, Yu J, MacLauchlan S, Skokos EA, Tian W, Bornstein P, Sessa WC, Kyriakides TR. Thrombospondin-2 modulates extracellular matrix remodeling during physiological angiogenesis. The American Journal of Pathology. 173: 879-91. PMID 18688033 DOI: 10.2353/Ajpath.2008.080128  0.381
2008 Rodriguez-Feo JA, Hellings WE, Moll FL, De Vries JP, van Middelaar BJ, Algra A, Sluijter J, Velema E, van den Broek T, Sessa WC, De Kleijn DP, Pasterkamp G. Caveolin-1 influences vascular protease activity and is a potential stabilizing factor in human atherosclerotic disease. Plos One. 3: e2612. PMID 18596970 DOI: 10.1371/Journal.Pone.0002612  0.374
2008 Facchinetti V, Ouyang W, Wei H, Soto N, Lazorchak A, Gould C, Lowry C, Newton AC, Mao Y, Miao RQ, Sessa WC, Qin J, Zhang P, Su B, Jacinto E. The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. The Embo Journal. 27: 1932-43. PMID 18566586 DOI: 10.1038/Emboj.2008.120  0.345
2008 Schleicher M, Sessa WC. Are the mechanisms for NO-dependent vascular remodeling different from vasorelaxation in vivo? Arteriosclerosis, Thrombosis, and Vascular Biology. 28: 1207-8. PMID 18565841 DOI: 10.1161/Atvbaha.108.167403  0.483
2008 Tourkina E, Richard M, Gööz P, Bonner M, Pannu J, Harley R, Bernatchez PN, Sessa WC, Silver RM, Hoffman S. Antifibrotic properties of caveolin-1 scaffolding domain in vitro and in vivo. American Journal of Physiology. Lung Cellular and Molecular Physiology. 294: L843-61. PMID 18203815 DOI: 10.1152/Ajplung.00295.2007  0.31
2008 Schleicher M, Shepherd BR, Suarez Y, Fernandez-Hernando C, Yu J, Pan Y, Acevedo LM, Shadel GS, Sessa WC. Prohibitin-1 maintains the angiogenic capacity of endothelial cells by regulating mitochondrial function and senescence. The Journal of Cell Biology. 180: 101-12. PMID 18195103 DOI: 10.1083/Jcb.200706072  0.785
2008 Sowa G, Xie L, Xu L, Sessa WC. Serine 23 and 36 phosphorylation of caveolin-2 is differentially regulated by targeting to lipid raft/caveolae and in mitotic endothelial cells. Biochemistry. 47: 101-11. PMID 18081315 DOI: 10.1021/Bi701709S  0.428
2008 Miao RQ, Fontana J, Fulton D, Lin MI, Harrison KD, Sessa WC. Dominant-negative Hsp90 reduces VEGF-stimulated nitric oxide release and migration in endothelial cells. Arteriosclerosis, Thrombosis, and Vascular Biology. 28: 105-11. PMID 17975117 DOI: 10.1161/Atvbaha.107.155499  0.81
2008 Schleicher M, Yu J, Murata T, Harrisson KD, Huang PL, Sessa WC. O48. Phosphorylation of eNOS on Serine 1176 by Akt1 is indispensable for pathophysiological angiogenesis Nitric Oxide. 19: 31. DOI: 10.1016/J.Niox.2008.06.049  0.337
2007 Fernández-Hernando C, Ackah E, Yu J, Suárez Y, Murata T, Iwakiri Y, Prendergast J, Miao RQ, Birnbaum MJ, Sessa WC. Loss of Akt1 leads to severe atherosclerosis and occlusive coronary artery disease. Cell Metabolism. 6: 446-57. PMID 18054314 DOI: 10.1016/J.Cmet.2007.10.007  0.8
2007 Li L, Hisamoto K, Kim KH, Haynes MP, Bauer PM, Sanjay A, Collinge M, Baron R, Sessa WC, Bender JR. Variant estrogen receptor-c-Src molecular interdependence and c-Src structural requirements for endothelial NO synthase activation. Proceedings of the National Academy of Sciences of the United States of America. 104: 16468-73. PMID 17921256 DOI: 10.1073/Pnas.0704315104  0.366
2007 Pober JS, Sessa WC. Evolving functions of endothelial cells in inflammation. Nature Reviews. Immunology. 7: 803-15. PMID 17893694 DOI: 10.1038/Nri2171  0.42
2007 Murata T, Lin MI, Huang Y, Yu J, Bauer PM, Giordano FJ, Sessa WC. Reexpression of caveolin-1 in endothelium rescues the vascular, cardiac, and pulmonary defects in global caveolin-1 knockout mice. The Journal of Experimental Medicine. 204: 2373-82. PMID 17893196 DOI: 10.1084/Jem.20062340  0.626
2007 Bernatchez PN, Acevedo L, Fernandez-Hernando C, Murata T, Chalouni C, Kim J, Erdjument-Bromage H, Shah V, Gratton JP, McNally EM, Tempst P, Sessa WC. Myoferlin regulates vascular endothelial growth factor receptor-2 stability and function. The Journal of Biological Chemistry. 282: 30745-53. PMID 17702744 DOI: 10.1074/Jbc.M704798200  0.804
2007 Atochin DN, Wang A, Liu VW, Critchlow JD, Dantas AP, Looft-Wilson R, Murata T, Salomone S, Shin HK, Ayata C, Moskowitz MA, Michel T, Sessa WC, Huang PL. The phosphorylation state of eNOS modulates vascular reactivity and outcome of cerebral ischemia in vivo. The Journal of Clinical Investigation. 117: 1961-7. PMID 17557122 DOI: 10.1172/Jci29877  0.437
2007 Kudo FA, Muto A, Maloney SP, Pimiento JM, Bergaya S, Fitzgerald TN, Westvik TS, Frattini JC, Breuer CK, Cha CH, Nishibe T, Tellides G, Sessa WC, Dardik A. Venous identity is lost but arterial identity is not gained during vein graft adaptation. Arteriosclerosis, Thrombosis, and Vascular Biology. 27: 1562-71. PMID 17463332 DOI: 10.1161/Atvbaha.107.143032  0.305
2007 Murata T, Lin MI, Stan RV, Bauer PM, Yu J, Sessa WC. Genetic evidence supporting caveolae microdomain regulation of calcium entry in endothelial cells. The Journal of Biological Chemistry. 282: 16631-43. PMID 17416589 DOI: 10.1074/Jbc.M607948200  0.601
2007 Rodriguez-Feo JA, Hellings WE, Verhoeven BA, Moll FL, de Kleijn DP, Prendergast J, Gao Y, van der Graaf Y, Tellides G, Sessa WC, Pasterkamp G. Low levels of Nogo-B in human carotid atherosclerotic plaques are associated with an atheromatous phenotype, restenosis, and stenosis severity. Arteriosclerosis, Thrombosis, and Vascular Biology. 27: 1354-60. PMID 17413036 DOI: 10.1161/Atvbaha.107.140913  0.312
2007 Morales-Ruiz M, Fondevila C, Muñoz-Luque J, Tugues S, Rodríguez-Laiz G, Cejudo-Martín P, Romero JM, Navasa M, Fuster J, Arroyo V, Sessa WC, García-Valdecasas JC, Jiménez W. Gene transduction of an active mutant of akt exerts cytoprotection and reduces graft injury after liver transplantation. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 7: 769-78. PMID 17391122 DOI: 10.1111/J.1600-6143.2006.01720.X  0.321
2007 Suárez Y, Fernández-Hernando C, Pober JS, Sessa WC. Dicer dependent microRNAs regulate gene expression and functions in human endothelial cells. Circulation Research. 100: 1164-73. PMID 17379831 DOI: 10.1161/01.Res.0000265065.26744.17  0.365
2007 Lin MI, Yu J, Murata T, Sessa WC. Caveolin-1-deficient mice have increased tumor microvascular permeability, angiogenesis, and growth. Cancer Research. 67: 2849-56. PMID 17363608 DOI: 10.1158/0008-5472.Can-06-4082  0.604
2007 Zhang H, Luo Y, Zhang W, He Y, Dai S, Zhang R, Huang Y, Bernatchez P, Giordano FJ, Shadel G, Sessa WC, Min W. Endothelial-specific expression of mitochondrial thioredoxin improves endothelial cell function and reduces atherosclerotic lesions. The American Journal of Pathology. 170: 1108-20. PMID 17322393 DOI: 10.2353/Ajpath.2007.060960  0.455
2007 Marin E, Sessa WC. Role of endothelial-derived nitric oxide in hypertension and renal disease. Current Opinion in Nephrology and Hypertension. 16: 105-10. PMID 17293684 DOI: 10.1097/Mnh.0B013E328017F893  0.382
2007 Sessa WC. Nitric oxide synthase inhibition and cancer. The Lancet. Oncology. 8: 88-9. PMID 17267319 DOI: 10.1016/S1470-2045(07)70006-2  0.318
2007 Pyriochou A, Zhou Z, Koika V, Petrou C, Cordopatis P, Sessa WC, Papapetropoulos A. The phosphodiesterase 5 inhibitor sildenafil stimulates angiogenesis through a protein kinase G/MAPK pathway. Journal of Cellular Physiology. 211: 197-204. PMID 17226792 DOI: 10.1002/Jcp.20929  0.439
2007 Paszkowiak JJ, Maloney SP, Kudo FA, Muto A, Teso D, Rutland RC, Westvik TS, Pimiento JM, Tellides G, Sessa WC, Dardik A. Evidence supporting changes in Nogo-B levels as a marker of neointimal expansion but not adaptive arterial remodeling. Vascular Pharmacology. 46: 293-301. PMID 17207665 DOI: 10.1016/J.Vph.2006.11.003  0.341
2007 Hooper WC, Catravas JD, Heistad DD, Sessa WC, Mensah GA. Vascular endothelium summary statement I: Health promotion and chronic disease prevention. Vascular Pharmacology. 46: 315-7. PMID 17197248 DOI: 10.1016/J.Vph.2006.10.014  0.33
2006 Iwakiri Y, Satoh A, Chatterjee S, Toomre DK, Chalouni CM, Fulton D, Groszmann RJ, Shah VH, Sessa WC. Nitric oxide synthase generates nitric oxide locally to regulate compartmentalized protein S-nitrosylation and protein trafficking. Proceedings of the National Academy of Sciences of the United States of America. 103: 19777-82. PMID 17170139 DOI: 10.1073/Pnas.0605907103  0.362
2006 Luo D, Luo Y, He Y, Zhang H, Zhang R, Li X, Dobrucki WL, Sinusas AJ, Sessa WC, Min W. Differential functions of tumor necrosis factor receptor 1 and 2 signaling in ischemia-mediated arteriogenesis and angiogenesis. The American Journal of Pathology. 169: 1886-98. PMID 17071609 DOI: 10.2353/Ajpath.2006.060603  0.488
2006 Lin MI, Sessa WC. Vascular endothelial growth factor signaling to endothelial nitric oxide synthase: more than a FLeeTing moment. Circulation Research. 99: 666-8. PMID 17008595 DOI: 10.1161/01.Res.0000245430.24075.A4  0.666
2006 He Y, Luo Y, Tang S, Rajantie I, Salven P, Heil M, Zhang R, Luo D, Li X, Chi H, Yu J, Carmeliet P, Schaper W, Sinusas AJ, Sessa WC, et al. Critical function of Bmx/Etk in ischemia-mediated arteriogenesis and angiogenesis Journal of Clinical Investigation. 116: 2344-2355. PMID 16932810 DOI: 10.1172/Jci28123  0.431
2006 Phung TL, Ziv K, Dabydeen D, Eyiah-Mensah G, Riveros M, Perruzzi C, Sun J, Monahan-Earley RA, Shiojima I, Nagy JA, Lin MI, Walsh K, Dvorak AM, Briscoe DM, Neeman M, ... Sessa WC, et al. Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin Cancer Cell. 10: 159-170. PMID 16904613 DOI: 10.1016/J.Ccr.2006.07.003  0.643
2006 Fernández-Hernando C, Fukata M, Bernatchez PN, Fukata Y, Lin MI, Bredt DS, Sessa WC. Identification of Golgi-localized acyl transferases that palmitoylate and regulate endothelial nitric oxide synthase. The Journal of Cell Biology. 174: 369-77. PMID 16864653 DOI: 10.1083/Jcb.200601051  0.659
2006 Miao RQ, Gao Y, Harrison KD, Prendergast J, Acevedo LM, Yu J, Hu F, Strittmatter SM, Sessa WC. Identification of a receptor necessary for Nogo-B stimulated chemotaxis and morphogenesis of endothelial cells. Proceedings of the National Academy of Sciences of the United States of America. 103: 10997-1002. PMID 16835300 DOI: 10.1073/Pnas.0602427103  0.8
2006 Bhandari V, Choo-Wing R, Chapoval SP, Lee CG, Tang C, Kim YK, Ma B, Baluk P, Lin MI, McDonald DM, Homer RJ, Sessa WC, Elias JA. Essential role of nitric oxide in VEGF-induced, asthma-like angiogenic, inflammatory, mucus, and physiologic responses in the lung. Proceedings of the National Academy of Sciences of the United States of America. 103: 11021-6. PMID 16832062 DOI: 10.1073/Pnas.0601057103  0.665
2006 Boo YC, Kim HJ, Song H, Fulton D, Sessa W, Jo H. Coordinated regulation of endothelial nitric oxide synthase activity by phosphorylation and subcellular localization. Free Radical Biology & Medicine. 41: 144-53. PMID 16781462 DOI: 10.1016/J.Freeradbiomed.2006.03.024  0.413
2006 Hatakeyama T, Pappas PJ, Hobson RW, Boric MP, Sessa WC, Durán WN. Endothelial nitric oxide synthase regulates microvascular hyperpermeability in vivo. The Journal of Physiology. 574: 275-81. PMID 16675496 DOI: 10.1113/Jphysiol.2006.108175  0.441
2006 Yu J, Bergaya S, Murata T, Alp IF, Bauer MP, Lin MI, Drab M, Kurzchalia TV, Stan RV, Sessa WC. Direct evidence for the role of caveolin-1 and caveolae in mechanotransduction and remodeling of blood vessels. The Journal of Clinical Investigation. 116: 1284-91. PMID 16670769 DOI: 10.1172/Jci27100  0.613
2006 Qian HS, Liu P, Huw LY, Orme A, Halks-Miller M, Hill SM, Jin F, Kretschmer P, Blasko E, Cashion L, Szymanski P, Vergona R, Harkins R, Yu J, Sessa WC, et al. Effective treatment of vascular endothelial growth factor refractory hindlimb ischemia by a mutant endothelial nitric oxide synthase gene. Gene Therapy. 13: 1342-50. PMID 16642030 DOI: 10.1038/sj.gt.3302781  0.332
2006 Abraldes JG, Iwakiri Y, Loureiro-Silva M, Haq O, Sessa WC, Groszmann RJ. Mild increases in portal pressure upregulate vascular endothelial growth factor and endothelial nitric oxide synthase in the intestinal microcirculatory bed, leading to a hyperdynamic state. American Journal of Physiology. Gastrointestinal and Liver Physiology. 290: G980-7. PMID 16603731 DOI: 10.1152/Ajpgi.00336.2005  0.438
2006 Zhang Q, Church JE, Jagnandan D, Catravas JD, Sessa WC, Fulton D. Functional relevance of Golgi- and plasma membrane-localized endothelial NO synthase in reconstituted endothelial cells. Arteriosclerosis, Thrombosis, and Vascular Biology. 26: 1015-21. PMID 16514082 DOI: 10.1161/01.Atv.0000216044.49494.C4  0.418
2006 Yu J, Lei L, Liang Y, Hinh L, Hickey RP, Huang Y, Liu D, Yeh JL, Rebar E, Case C, Spratt K, Sessa WC, Giordano FJ. An engineered VEGF-activating zinc finger protein transcription factor improves blood flow and limb salvage in advanced-age mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 479-81. PMID 16423874 DOI: 10.1096/Fj.04-3670Fje  0.427
2006 Iwakiri Y, Satoh A, Chatterjee S, Shah V, Toomre D, Chalouni CM, Fulton D, Groszmann R, Sessa WC. P013. Nitric oxide synthase establishes a local nitric oxide gradient regulating S-nitrosylation and protein secretion Nitric Oxide. 14: 21. DOI: 10.1016/J.Niox.2006.04.072  0.352
2006 Fernández C, Fukata M, Bernatchez P, Fukata Y, Lin M, Bredt DS, Sessa WC. O08. Identification of Golgi localized acyl transferases that palmitoylate and regulate endothelial nitric oxide synthase Nitric Oxide. 14: 3. DOI: 10.1016/J.Niox.2006.04.012  0.614
2006 Maloney SP, Yakimov A, Muto A, Tang P, Pimiento J, Kudo F, Westvik T, Dudrick S, Sessa W, Tellides G, Dardik A. Murine carotid aneurysms develop without down regulation of Nogo-B expression: A novel model for human thoracic aneurysms Journal of the American College of Surgeons. 203: S22. DOI: 10.1016/J.Jamcollsurg.2006.05.053  0.306
2005 Partovian C, Zhuang Z, Moodie K, Lin M, Ouchi N, Sessa WC, Walsh K, Simons M. PKCalpha activates eNOS and increases arterial blood flow in vivo. Circulation Research. 97: 482-7. PMID 16081872 DOI: 10.1161/01.Res.0000179775.04114.45  0.671
2005 Ackah E, Yu J, Zoellner S, Iwakiri Y, Skurk C, Shibata R, Ouchi N, Easton RM, Galasso G, Birnbaum MJ, Walsh K, Sessa WC. Akt1/protein kinase Balpha is critical for ischemic and VEGF-mediated angiogenesis. The Journal of Clinical Investigation. 115: 2119-27. PMID 16075056 DOI: 10.1172/Jci24726  0.824
2005 Yu J, deMuinck ED, Zhuang Z, Drinane M, Kauser K, Rubanyi GM, Qian HS, Murata T, Escalante B, Sessa WC. Endothelial nitric oxide synthase is critical for ischemic remodeling, mural cell recruitment, and blood flow reserve. Proceedings of the National Academy of Sciences of the United States of America. 102: 10999-1004. PMID 16043715 DOI: 10.1073/Pnas.0501444102  0.459
2005 Papapetropoulos A, Zhou Z, Gerassimou C, Yetik G, Venema RC, Roussos C, Sessa WC, Catravas JD. Interaction between the 90-kDa heat shock protein and soluble guanylyl cyclase: physiological significance and mapping of the domains mediating binding. Molecular Pharmacology. 68: 1133-41. PMID 16024662 DOI: 10.1124/Mol.105.012682  0.302
2005 Sessa WC. Regulation of endothelial derived nitric oxide in health and disease. MemóRias Do Instituto Oswaldo Cruz. 100: 15-8. PMID 15962093 DOI: 10.1590/S0074-02762005000900004  0.437
2005 Jagnandan D, Sessa WC, Fulton D. Intracellular location regulates calcium-calmodulin-dependent activation of organelle-restricted eNOS. American Journal of Physiology. Cell Physiology. 289: C1024-33. PMID 15917301 DOI: 10.1152/Ajpcell.00162.2005  0.399
2005 Zhang R, Luo D, Miao R, Bai L, Ge Q, Sessa WC, Min W. Hsp90-Akt phosphorylates ASK1 and inhibits ASK1-mediated apoptosis. Oncogene. 24: 3954-63. PMID 15782121 DOI: 10.1038/Sj.Onc.1208548  0.368
2005 Bucci M, Roviezzo F, Posadas I, Yu J, Parente L, Sessa WC, Ignarro LJ, Cirino G. Endothelial nitric oxide synthase activation is critical for vascular leakage during acute inflammation in vivo Proceedings of the National Academy of Sciences of the United States of America. 102: 904-908. PMID 15640348 DOI: 10.1073/Pnas.0408906102  0.497
2005 Bernatchez PN, Bauer PM, Yu J, Prendergast JS, He P, Sessa WC. Dissecting the molecular control of endothelial NO synthase by caveolin-1 using cell-permeable peptides. Proceedings of the National Academy of Sciences of the United States of America. 102: 761-6. PMID 15637154 DOI: 10.1073/Pnas.0407224102  0.385
2005 Bauer PM, Yu J, Chen Y, Hickey R, Bernatchez PN, Looft-Wilson R, Huang Y, Giordano F, Stan RV, Sessa WC. Endothelial-specific expression of caveolin-1 impairs microvascular permeability and angiogenesis. Proceedings of the National Academy of Sciences of the United States of America. 102: 204-9. PMID 15615855 DOI: 10.1073/Pnas.0406092102  0.539
2005 Sorenson J, Santhanam AV, Smith LA, Akiyama M, Sessa WC, Katusic ZS. Expression and function of recombinant S1179D endothelial NO synthase in human pial arteries. Stroke; a Journal of Cerebral Circulation. 36: 158-60. PMID 15569867 DOI: 10.1161/01.Str.0000150489.47080.67  0.397
2004 Lin MI, Sessa WC. Antiangiogenic therapy: creating a unique "window" of opportunity. Cancer Cell. 6: 529-31. PMID 15607955 DOI: 10.1016/J.Ccr.2004.12.003  0.523
2004 Koh KP, Wang Y, Yi T, Shiao SL, Lorber MI, Sessa WC, Tellides G, Pober JS. T cell-mediated vascular dysfunction of human allografts results from IFN-gamma dysregulation of NO synthase. The Journal of Clinical Investigation. 114: 846-56. PMID 15372109 DOI: 10.1172/Jci21767  0.396
2004 Gratton JP, Bernatchez P, Sessa WC. Caveolae and caveolins in the cardiovascular system. Circulation Research. 94: 1408-17. PMID 15192036 DOI: 10.1161/01.Res.0000129178.56294.17  0.394
2004 Hagendoorn J, Padera TP, Kashiwagi S, Isaka N, Noda F, Lin MI, Huang PL, Sessa WC, Fukumura D, Jain RK. Endothelial nitric oxide synthase regulates microlymphatic flow via collecting lymphatics. Circulation Research. 95: 204-9. PMID 15192027 DOI: 10.1161/01.Res.0000135549.72828.24  0.628
2004 Sessa WC. eNOS at a glance. Journal of Cell Science. 117: 2427-9. PMID 15159447 DOI: 10.1242/Jcs.01165  0.44
2004 Fulton D, Babbitt R, Zoellner S, Fontana J, Acevedo L, McCabe TJ, Iwakiri Y, Sessa WC. Targeting of endothelial nitric-oxide synthase to the cytoplasmic face of the Golgi complex or plasma membrane regulates Akt- versus calcium-dependent mechanisms for nitric oxide release. The Journal of Biological Chemistry. 279: 30349-57. PMID 15136572 DOI: 10.1074/Jbc.M402155200  0.785
2004 Kuhlencordt PJ, Rosel E, Gerszten RE, Morales-Ruiz M, Dombkowski D, Atkinson WJ, Han F, Preffer F, Rosenzweig A, Sessa WC, Gimbrone MA, Ertl G, Huang PL. Role of endothelial nitric oxide synthase in endothelial activation: insights from eNOS knockout endothelial cells. American Journal of Physiology. Cell Physiology. 286: C1195-202. PMID 15075219 DOI: 10.1152/Ajpcell.00546.2002  0.467
2004 Acevedo L, Yu J, Erdjument-Bromage H, Miao RQ, Kim JE, Fulton D, Tempst P, Strittmatter SM, Sessa WC. A new role for Nogo as a regulator of vascular remodeling. Nature Medicine. 10: 382-8. PMID 15034570 DOI: 10.1038/Nm1020  0.804
2004 Bucci M, Roviezzo F, Brancaleone V, Lin MI, Di Lorenzo A, Cicala C, Pinto A, Sessa WC, Farneti S, Fiorucci S, Cirino G. Diabetic mouse angiopathy is linked to progressive sympathetic receptor deletion coupled to an enhanced caveolin-1 expression. Arteriosclerosis, Thrombosis, and Vascular Biology. 24: 721-6. PMID 14962949 DOI: 10.1161/01.Atv.0000122362.44628.09  0.565
2004 Payne GW, Madri JA, Sessa WC, Segal SS. Histamine inhibits conducted vasodilation through endothelium-derived NO production in arterioles of mouse skeletal muscle. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 280-6. PMID 14769822 DOI: 10.1096/Fj.03-0752Com  0.359
2004 Papapetropoulos A, Fulton D, Lin MI, Fontana J, McCabe TJ, Zoellner S, García-Cardeña G, Zhou Z, Gratton JP, Sessa WC. Vanadate is a potent activator of endothelial nitric-oxide synthase: evidence for the role of the serine/threonine kinase Akt and the 90-kDa heat shock protein. Molecular Pharmacology. 65: 407-15. PMID 14742683 DOI: 10.1124/Mol.65.2.407  0.813
2004 Wang Y, Burns WR, Tang PC, Yi T, Schechner JS, Zerwes HG, Sessa WC, Lorber MI, Pober JS, Tellides G. Interferon-gamma plays a nonredundant role in mediating T cell-dependent outward vascular remodeling of allogeneic human coronary arteries. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 606-8. PMID 14734640 DOI: 10.1096/Fj.03-0840Fje  0.337
2004 Sessa WC. Atheroprotection in the abence of "caves": is it the fat, the vessels, or both? Arteriosclerosis, Thrombosis, and Vascular Biology. 24: 4-6. PMID 14707034 DOI: 10.1161/01.Atv.0000102552.84528.8F  0.364
2004 Ou J, Fontana JT, Ou Z, Jones DW, Ackerman AW, Oldham KT, Yu J, Sessa WC, Pritchard KA. Heat shock protein 90 and tyrosine kinase regulate eNOS NO* generation but not NO* bioactivity. American Journal of Physiology. Heart and Circulatory Physiology. 286: H561-9. PMID 14551044 DOI: 10.1152/Ajpheart.00736.2003  0.779
2004 Yu J, Hickey R, Huang Y, Rebar E, Sessa WC, Giordano FJ. 1049. Engineered ZFPs Can Prevent Limb Loss in Mice Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.994  0.379
2004 Frattini JC, Sessa W, Sumpio B, Dardik A. Effects of turbulent flow on cell adhesion molecule expression in endothelial cells Journal of the American College of Surgeons. 199: 112. DOI: 10.1016/J.Jamcollsurg.2004.05.253  0.312
2004 Koh KP, Wang Y, Yi T, Lorber MI, Sessa WC, Tellides G, Pober JS. HUMAN ALLOGENEIC T CELL-MEDIATED VASCULAR DYSFUNCTION DEPENDS ON INTERFERON-GAMMA Cardiovascular Pathology. 13: 9. DOI: 10.1016/J.Carpath.2004.03.021  0.362
2003 Fortugno P, Beltrami E, Plescia J, Fontana J, Pradhan D, Marchisio PC, Sessa WC, Altieri DC. Regulation of survivin function by Hsp90. Proceedings of the National Academy of Sciences of the United States of America. 100: 13791-6. PMID 14614132 DOI: 10.1073/Pnas.2434345100  0.715
2003 Minshall RD, Sessa WC, Stan RV, Anderson RG, Malik AB. Caveolin regulation of endothelial function. American Journal of Physiology. Lung Cellular and Molecular Physiology. 285: L1179-83. PMID 14604847 DOI: 10.1152/Ajplung.00242.2003  0.442
2003 Tsai MH, Iwakiri Y, Cadelina G, Sessa WC, Groszmann RJ. Mesenteric vasoconstriction triggers nitric oxide overproduction in the superior mesenteric artery of portal hypertensive rats. Gastroenterology. 125: 1452-61. PMID 14598261 DOI: 10.1016/J.Gastro.2003.07.014  0.329
2003 Boo YC, Sorescu GP, Bauer PM, Fulton D, Kemp BE, Harrison DG, Sessa WC, Jo H. Endothelial NO synthase phosphorylated at SER635 produces NO without requiring intracellular calcium increase. Free Radical Biology & Medicine. 35: 729-41. PMID 14583337 DOI: 10.1016/S0891-5849(03)00397-6  0.386
2003 Jiang J, Cyr D, Babbitt RW, Sessa WC, Patterson C. Chaperone-dependent regulation of endothelial nitric-oxide synthase intracellular trafficking by the co-chaperone/ubiquitin ligase CHIP. The Journal of Biological Chemistry. 278: 49332-41. PMID 14507928 DOI: 10.1074/Jbc.M304738200  0.464
2003 Lin MI, Fulton D, Babbitt R, Fleming I, Busse R, Pritchard KA, Sessa WC. Phosphorylation of threonine 497 in endothelial nitric-oxide synthase coordinates the coupling of L-arginine metabolism to efficient nitric oxide production. The Journal of Biological Chemistry. 278: 44719-26. PMID 12952971 DOI: 10.1074/Jbc.M302836200  0.659
2003 Gratton JP, Lin MI, Yu J, Weiss ED, Jiang ZL, Fairchild TA, Iwakiri Y, Groszmann R, Claffey KP, Cheng YC, Sessa WC. Selective inhibition of tumor microvascular permeability by cavtratin blocks tumor progression in mice. Cancer Cell. 4: 31-9. PMID 12892711 DOI: 10.1016/S1535-6108(03)00168-5  0.565
2003 Morales-Ruiz M, Cejudo-Martín P, Fernández-Varo G, Tugues S, Ros J, Angeli P, Rivera F, Arroyo V, Rodés J, Sessa WC, Jiménez W. Transduction of the liver with activated Akt normalizes portal pressure in cirrhotic rats. Gastroenterology. 125: 522-31. PMID 12891555 DOI: 10.1016/S0016-5085(03)00909-0  0.348
2003 Post H, Kajstura J, Lei B, Sessa WC, Byrne B, Anversa P, Hintze TH, Recchia FA. Adeno-associated virus mediated gene delivery into coronary microvessels of chronically instrumented dogs. Journal of Applied Physiology (Bethesda, Md. : 1985). 95: 1688-94. PMID 12844500 DOI: 10.1152/Japplphysiol.00896.2002  0.301
2003 Hendrickson H, Chatterjee S, Cao S, Morales Ruiz M, Sessa WC, Shah V. Influence of caveolin on constitutively activated recombinant eNOS: insights into eNOS dysfunction in BDL rat liver. American Journal of Physiology. Gastrointestinal and Liver Physiology. 285: G652-60. PMID 12829439 DOI: 10.1152/Ajpgi.00143.2003  0.335
2003 Peterson TE, Guicciardi ME, Gulati R, Kleppe LS, Mueske CS, Mookadam M, Sowa G, Gores GJ, Sessa WC, Simari RD. Caveolin-1 can regulate vascular smooth muscle cell fate by switching platelet-derived growth factor signaling from a proliferative to an apoptotic pathway. Arteriosclerosis, Thrombosis, and Vascular Biology. 23: 1521-7. PMID 12816877 DOI: 10.1161/01.Atv.0000081743.35125.05  0.378
2003 Sowa G, Pypaert M, Fulton D, Sessa WC. The phosphorylation of caveolin-2 on serines 23 and 36 modulates caveolin-1-dependent caveolae formation. Proceedings of the National Academy of Sciences of the United States of America. 100: 6511-6. PMID 12743374 DOI: 10.1073/Pnas.1031672100  0.358
2003 Payne GW, Madri JA, Sessa WC, Segal SS. Abolition of arteriolar dilation but not constriction to histamine in cremaster muscle of eNOS-/- mice. American Journal of Physiology. Heart and Circulatory Physiology. 285: H493-8. PMID 12689855 DOI: 10.1152/Ajpheart.00071.2003  0.374
2003 Bauer PM, Fulton D, Boo YC, Sorescu GP, Kemp BE, Jo H, Sessa WC. Compensatory phosphorylation and protein-protein interactions revealed by loss of function and gain of function mutants of multiple serine phosphorylation sites in endothelial nitric-oxide synthase. The Journal of Biological Chemistry. 278: 14841-9. PMID 12591925 DOI: 10.1074/Jbc.M211926200  0.371
2003 Cirino G, Fiorucci S, Sessa WC. Endothelial nitric oxide synthase: the Cinderella of inflammation? Trends in Pharmacological Sciences. 24: 91-5. PMID 12559774 DOI: 10.1016/S0165-6147(02)00049-4  0.489
2003 Haynes MP, Li L, Sinha D, Russell KS, Hisamoto K, Baron R, Collinge M, Sessa WC, Bender JR. Src kinase mediates phosphatidylinositol 3-kinase/Akt-dependent rapid endothelial nitric-oxide synthase activation by estrogen Journal of Biological Chemistry. 278: 2118-2123. PMID 12431978 DOI: 10.1074/Jbc.M210828200  0.384
2002 Nedvetsky PI, Sessa WC, Schmidt HH. There's NO binding like NOS binding: protein-protein interactions in NO/cGMP signaling. Proceedings of the National Academy of Sciences of the United States of America. 99: 16510-2. PMID 12486234 DOI: 10.1073/Pnas.262701999  0.367
2002 Iwakiri Y, Cadelina G, Sessa WC, Groszmann RJ. Mice with targeted deletion of eNOS develop hyperdynamic circulation associated with portal hypertension. American Journal of Physiology. Gastrointestinal and Liver Physiology. 283: G1074-81. PMID 12381520 DOI: 10.1152/Ajpgi.00145.2002  0.388
2002 Napoli C, Ackah E, De Nigris F, Del Soldato P, D'Armiento FP, Crimi E, Condorelli M, Sessa WC. Chronic treatment with nitric oxide-releasing aspirin reduces plasma low-density lipoprotein oxidation and oxidative stress, arterial oxidation-specific epitopes, and atherogenesis in hypercholesterolemic mice. Proceedings of the National Academy of Sciences of the United States of America. 99: 12467-70. PMID 12209007 DOI: 10.1073/Pnas.192244499  0.783
2002 Blanc-Brude OP, Yu J, Simosa H, Conte MS, Sessa WC, Altieri DC. Inhibitor of apoptosis protein survivin regulates vascular injury. Nature Medicine. 8: 987-94. PMID 12172543 DOI: 10.1038/Nm750  0.425
2002 Yu J, Rudic RD, Sessa WC. Nitric oxide-releasing aspirin decreases vascular injury by reducing inflammation and promoting apoptosis. Laboratory Investigation; a Journal of Technical Methods and Pathology. 82: 825-32. PMID 12118084 DOI: 10.1097/01.Lab.0000018828.61722.Bd  0.753
2002 Pritchard KA, Ackerman AW, Ou J, Curtis M, Smalley DM, Fontana JT, Stemerman MB, Sessa WC. Native low-density lipoprotein induces endothelial nitric oxide synthase dysfunction: role of heat shock protein 90 and caveolin-1. Free Radical Biology & Medicine. 33: 52-62. PMID 12086682 DOI: 10.1016/S0891-5849(02)00851-1  0.746
2002 Iwakiri Y, Tsai MH, McCabe TJ, Gratton JP, Fulton D, Groszmann RJ, Sessa WC. Phosphorylation of eNOS initiates excessive NO production in early phases of portal hypertension. American Journal of Physiology. Heart and Circulatory Physiology. 282: H2084-90. PMID 12003815 DOI: 10.1152/Ajpheart.00675.2001  0.411
2002 Scotland RS, Morales-Ruiz M, Chen Y, Yu J, Rudic RD, Fulton D, Gratton JP, Sessa WC. Functional reconstitution of endothelial nitric oxide synthase reveals the importance of serine 1179 in endothelium-dependent vasomotion. Circulation Research. 90: 904-10. PMID 11988492 DOI: 10.1161/01.Res.0000016506.04193.96  0.779
2002 Fontana J, Fulton D, Chen Y, Fairchild TA, McCabe TJ, Fujita N, Tsuruo T, Sessa WC. Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release. Circulation Research. 90: 866-73. PMID 11988487 DOI: 10.1161/01.Res.0000016837.26733.Be  0.779
2002 Akiyama M, Eguchi D, Weiler D, O'Brien T, Kovesdi I, Scotland RS, Sessa WC, Katusic ZS. Expression and function of recombinant S1179D endothelial nitric oxide synthase in canine cerebral arteries. Stroke. 33: 1071-6. PMID 11935063 DOI: 10.1161/Hs0402.105553  0.443
2002 Fulton D, Fontana J, Sowa G, Gratton JP, Lin M, Li KX, Michell B, Kemp BE, Rodman D, Sessa WC. Localization of endothelial nitric-oxide synthase phosphorylated on serine 1179 and nitric oxide in Golgi and plasma membrane defines the existence of two pools of active enzyme. The Journal of Biological Chemistry. 277: 4277-84. PMID 11729179 DOI: 10.1074/Jbc.M106302200  0.822
2002 Kim I, Oh JL, Ryu YS, So JN, Sessa WC, Walsh K, Koh GY. Angiopoietin-1 negatively regulates expression and activity of tissue factor in endothelial cells The Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 16: 126-128. PMID 11729102 DOI: 10.1096/Fj.01-0556Fje  0.467
2001 Sowa G, Pypaert M, Sessa WC. Distinction between signaling mechanisms in lipid rafts vs. caveolae. Proceedings of the National Academy of Sciences of the United States of America. 98: 14072-7. PMID 11707586 DOI: 10.1073/Pnas.241409998  0.409
2001 Lee MJ, Thangada S, Paik JH, Sapkota GP, Ancellin N, Chae SS, Wu M, Morales-Ruiz M, Sessa WC, Alessi DR, Hla T. Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis. Molecular Cell. 8: 693-704. PMID 11583630 DOI: 10.1016/S1097-2765(01)00324-0  0.403
2001 Paxinou E, Weisse M, Chen Q, Souza JM, Hertkorn C, Selak M, Daikhin E, Yudkoff M, Sowa G, Sessa WC, Ischiropoulos H. Dynamic regulation of metabolism and respiration by endogenously produced nitric oxide protects against oxidative stress. Proceedings of the National Academy of Sciences of the United States of America. 98: 11575-80. PMID 11562476 DOI: 10.1073/Pnas.201293198  0.366
2001 Gratton JP, Morales-Ruiz M, Kureishi Y, Fulton D, Walsh K, Sessa WC. Akt down-regulation of p38 signaling provides a novel mechanism of vascular endothelial growth factor-mediated cytoprotection in endothelial cells. The Journal of Biological Chemistry. 276: 30359-65. PMID 11387313 DOI: 10.1074/Jbc.M009698200  0.441
2001 Mesri M, Morales-Ruiz M, Ackermann EJ, Bennett CF, Pober JS, Sessa WC, Altieri DC. Suppression of vascular endothelial growth factor-mediated endothelial cell protection by survivin targeting American Journal of Pathology. 158: 1757-1765. PMID 11337373 DOI: 10.1016/S0002-9440(10)64131-4  0.45
2001 Fairchild TA, Fulton D, Fontana JT, Gratton JP, McCabe TJ, Sessa WC. Acidic hydrolysis as a mechanism for the cleavage of the Glu(298)-->Asp variant of human endothelial nitric-oxide synthase. The Journal of Biological Chemistry. 276: 26674-9. PMID 11331296 DOI: 10.1074/Jbc.M103647200  0.752
2001 Sessa WC. Can modulation of endothelial nitric oxide synthase explain the vasculoprotective actions of statins? Trends in Molecular Medicine. 7: 189-91. PMID 11325618 DOI: 10.1016/S1471-4914(01)01985-2  0.363
2001 Morales-Ruiz M, Lee MJ, Zöllner S, Gratton JP, Scotland R, Shiojima I, Walsh K, Hla T, Sessa WC. Sphingosine 1-phosphate activates Akt, nitric oxide production, and chemotaxis through a Gi protein/phosphoinositide 3-kinase pathway in endothelial cells. The Journal of Biological Chemistry. 276: 19672-7. PMID 11278592 DOI: 10.1074/Jbc.M009993200  0.454
2001 Pritchard KA, Ackerman AW, Gross ER, Stepp DW, Shi Y, Fontana JT, Baker JE, Sessa WC. Heat shock protein 90 mediates the balance of nitric oxide and superoxide anion from endothelial nitric-oxide synthase. The Journal of Biological Chemistry. 276: 17621-4. PMID 11278264 DOI: 10.1074/Jbc.C100084200  0.761
2001 Iwakiri Y, Tsai M, Sessa WC, Groszmann RJ. The phosphorylation of endothelial nitric oxide synthase by Akt increases nitric oxide production in early portal hypertension Gastroenterology. 120: A9. DOI: 10.1016/S0016-5085(08)80044-3  0.416
2000 Cao S, Yao J, McCabe TJ, Yao Q, Katusic ZS, Sessa WC, Shah V. Direct interaction between endothelial nitric-oxide synthase and dynamin-2. Implications for nitric-oxide synthase function. The Journal of Biological Chemistry. 276: 14249-56. PMID 11120737 DOI: 10.1074/Jbc.M006258200  0.456
2000 Bucci M, Gratton JP, Rudic RD, Acevedo L, Roviezzo F, Cirino G, Sessa WC. In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation. Nature Medicine. 6: 1362-7. PMID 11100121 DOI: 10.1038/82176  0.814
2000 Mital S, Zhang X, Zhao G, Bernstein RD, Smith CJ, Fulton DL, Sessa WC, Liao JK, Hintze TH. Simvastatin upregulates coronary vascular endothelial nitric oxide production in conscious dogs American Journal of Physiology - Heart and Circulatory Physiology. 279. PMID 11087217 DOI: 10.1152/Ajpheart.2000.279.6.H2649  0.386
2000 Haynes MP, Sinha D, Russell KS, Collinge M, Fulton D, Morales-Ruiz M, Sessa WC, Bender JR. Membrane estrogen receptor engagement activates endothelial nitric oxide synthase via the PI3-kinase-Akt pathway in human endothelial cells Circulation Research. 87: 677-682. PMID 11029403 DOI: 10.1161/01.Res.87.8.677  0.465
2000 Kureishi Y, Luo Z, Shiojima I, Bialik A, Fulton D, Lefer DJ, Sessa WC, Walsh K. The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals. Nature Medicine. 6: 1004-10. PMID 10973320 DOI: 10.1038/79510  0.509
2000 Bucci M, Roviezzo F, Cicala C, Sessa WC, Cirino G. Geldanamycin, an inhibitor of heat shock protein 90 (Hsp90) mediated signal transduction has anti-inflammatory effects and interacts with glucocorticoid receptor in vivo. British Journal of Pharmacology. 131: 13-6. PMID 10960063 DOI: 10.1038/Sj.Bjp.0703549  0.378
2000 Luo Z, Fujio Y, Kureishi Y, Rudic RD, Daumerie G, Fulton D, Sessa WC, Walsh K. Acute modulation of endothelial Akt/PKB activity alters nitric oxide-dependent vasomotor activity in vivo. The Journal of Clinical Investigation. 106: 493-9. PMID 10953024 DOI: 10.1172/Jci9419  0.774
2000 Rudic RD, Bucci M, Fulton D, Segal SS, Sessa WC. Temporal events underlying arterial remodeling after chronic flow reduction in mice: correlation of structural changes with a deficit in basal nitric oxide synthesis. Circulation Research. 86: 1160-6. PMID 10850968 DOI: 10.1161/01.Res.86.11.1160  0.733
2000 Morales-Ruiz M, Fulton D, Sowa G, Languino LR, Fujio Y, Walsh K, Sessa WC. Vascular endothelial growth factor-stimulated actin reorganization and migration of endothelial cells is regulated via the serine/threonine kinase Akt. Circulation Research. 86: 892-6. PMID 10785512 DOI: 10.1161/01.Res.86.8.892  0.473
2000 Gratton JP, Fontana J, O'Connor DS, Garcia-Cardena G, McCabe TJ, Sessa WC. Reconstitution of an endothelial nitric-oxide synthase (eNOS), hsp90, and caveolin-1 complex in vitro. Evidence that hsp90 facilitates calmodulin stimulated displacement of eNOS from caveolin-1. The Journal of Biological Chemistry. 275: 22268-72. PMID 10781589 DOI: 10.1074/Jbc.M001644200  0.765
2000 Papapetropoulos A, Fulton D, Mahboubi K, Kalb RG, O'Connor DS, Li F, Altieri DC, Sessa WC. Angiopoietin-1 inhibits endothelial cell apoptosis via the Akt/survivin pathway. The Journal of Biological Chemistry. 275: 9102-5. PMID 10734041 DOI: 10.1074/Jbc.275.13.9102  0.486
2000 McCabe TJ, Fulton D, Roman LJ, Sessa WC. Enhanced electron flux and reduced calmodulin dissociation may explain 'calcium-independent' eNOS activation by phosphorylation Journal of Biological Chemistry. 275: 6123-6128. PMID 10692402 DOI: 10.1074/Jbc.275.9.6123  0.393
2000 Russell KS, Haynes MP, Caulin-Glaser T, Rosneck J, Sessa WC, Bender JR. Estrogen stimulates heat shock protein 90 binding to endothelial nitric oxide synthase in human vascular endothelial cells. Effects on calcium sensitivity and no release Journal of Biological Chemistry. 275: 5026-5030. PMID 10671543 DOI: 10.1074/Jbc.275.7.5026  0.475
2000 Fulton D, Papapetropoulos A, Zhang X, Catravas JD, Hintze TH, Sessa WC. Quantification of eNOS mRNA in the canine cardiac vasculature by competitive PCR. American Journal of Physiology. Heart and Circulatory Physiology. 278: H658-65. PMID 10666099 DOI: 10.1152/Ajpheart.2000.278.2.H658  0.391
2000 Hungerford JE, Sessa WC, Segal SS. Vasomotor control in arterioles of the mouse cremaster muscle Faseb Journal. 14: 197-207. PMID 10627294 DOI: 10.1096/Fasebj.14.1.197  0.376
2000 Cao S, Yao J, McCabe TJ, Yao Q, Sessa WC, McNiven MA, Shah VH, Clin M. Dynamin binds and directly activates endothelial nitric oxide synthase Gastroenterology. 118: A958-A959. DOI: 10.1016/S0016-5085(00)85978-8  0.412
1999 Shah V, Wiest R, Garcia-Cardena G, Cadelina G, Groszmann RJ, Sessa WC. Hsp90 regulation of endothelial nitric oxide synthase contributes to vascular control in portal hypertension. American Journal of Physiology. Gastrointestinal and Liver Physiology. 277: G463-G468. PMID 29591697 DOI: 10.1152/Ajpgi.1999.277.2.G463  0.463
1999 Papapetropoulos A, Rudic RD, Sessa WC. Molecular control of nitric oxide synthases in the cardiovascular system. Cardiovascular Research. 43: 509-20. PMID 10690323 DOI: 10.1016/S0008-6363(99)00161-3  0.72
1999 Shah V, Toruner M, Haddad F, Cadelina G, Papapetropoulos A, Choo K, Sessa WC, Groszmann RJ. Impaired endothelial nitric oxide synthase activity associated with enhanced caveolin binding in experimental cirrhosis in the rat. Gastroenterology. 117: 1222-8. PMID 10535886 DOI: 10.1016/S0016-5085(99)70408-7  0.43
1999 Smart EJ, Graf GA, McNiven MA, Sessa WC, Engelman JA, Scherer PE, Okamoto T, Lisanti MP. Caveolins, liquid-ordered domains, and signal transduction. Molecular and Cellular Biology. 19: 7289-304. PMID 10523618 DOI: 10.1128/Mcb.19.11.7289  0.349
1999 Segal SS, Brett SE, Sessa WC. Codistribution of NOS and caveolin throughout peripheral vasculature and skeletal muscle of hamsters American Journal of Physiology - Heart and Circulatory Physiology. 277. PMID 10484439 DOI: 10.1152/Ajpheart.1999.277.3.H1167  0.367
1999 Sowa G, Liu J, Papapetropoulos A, Rex-Haffner M, Hughes TE, Sessa WC. Trafficking of endothelial nitric-oxide synthase in living cells. Quantitative evidence supporting the role of palmitoylation as a kinetic trapping mechanism limiting membrane diffusion. The Journal of Biological Chemistry. 274: 22524-31. PMID 10428829 DOI: 10.1074/Jbc.274.32.22524  0.385
1999 Fulton D, Gratton JP, McCabe TJ, Fontana J, Fujio Y, Walsh K, Franke TF, Papapetropoulos A, Sessa WC. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature. 399: 597-601. PMID 10376602 DOI: 10.1038/21218  0.786
1999 Wiest R, Shah V, Sessa WC, Groszmann RJ. NO overproduction by eNOS precedes hyperdynamic splanchnic circulation in portal hypertensive rats. The American Journal of Physiology. 276: G1043-51. PMID 10198349 DOI: 10.1152/Ajpgi.1999.276.4.G1043  0.355
1999 Guillot PV, Guan J, Liu L, Kuivenhoven JA, Rosenberg RD, Sessa WC, Aird WC. A vascular bed-specific pathway. The Journal of Clinical Investigation. 103: 799-805. PMID 10079100 DOI: 10.1172/Jci6017  0.424
1999 Rudic RD, Sessa WC. Nitric oxide in endothelial dysfunction and vascular remodeling: clinical correlates and experimental links. American Journal of Human Genetics. 64: 673-7. PMID 10052999 DOI: 10.1086/302304  0.743
1999 Malek AM, Jiang L, Lee I, Sessa WC, Izumo S, Alper SL. Induction of nitric oxide synthase mRNA by shear stress requires intracellular calcium and G-protein signals and is modulated by PI 3 kinase. Biochemical and Biophysical Research Communications. 254: 231-42. PMID 9920763 DOI: 10.1006/Bbrc.1998.9921  0.375
1999 Moy YP, Sessa WC, Weiss RM. INHIBITION OF ANGIOGENESIS AND TUMOR GROWTH IN HUMAN PROSTATE CANCER LNCaP CELLS WITH THE INHIBITION OF ENDOTHELIAL NITRIC OXIDE The Journal of Urology. 130. DOI: 10.1097/00005392-199904010-00522  0.364
1999 Fulton D, Gratton J, McCabe TJ, Fontana J, Fujio Y, Walsh K, Franke TF, Papapetropoulos A, Sessa WC. Erratum: Regulation of endothelium-derived nitric oxide production by the protein kinase Akt Nature. 400: 792-792. DOI: 10.1038/23523  0.749
1998 Wang X, Lu M, Gao Y, Papapetropoulos A, Sessa WC, Wang W. Neuronal nitric oxide synthase is expressed in principal cell of collecting duct. American Journal of Physiology. Renal Physiology. 275: F395-F399. PMID 29591686 DOI: 10.1152/Ajprenal.1998.275.3.F395  0.331
1998 Sierra-Honigmann MR, Nath AK, Murakami C, García-Cardeña G, Papapetropoulos A, Sessa WC, Madge LA, Schechner JS, Schwabb MB, Polverini PJ, Flores-Riveros JR. Biological action of leptin as an angiogenic factor. Science (New York, N.Y.). 281: 1683-6. PMID 9733517 DOI: 10.1126/Science.281.5383.1683  0.388
1998 Presta A, Liu J, Sessa WC, Stuehr DJ. Substrate binding and calmodulin binding to endothelial nitric oxide synthase coregulate its enzymatic activity. Nitric Oxide : Biology and Chemistry. 1: 74-87. PMID 9701047 DOI: 10.1006/Niox.1996.0110  0.436
1998 García-Cardeña G, Fan R, Shah V, Sorrentino R, Cirino G, Papapetropoulos A, Sessa WC. Dynamic activation of endothelial nitric oxide synthase by Hsp90 Nature. 392: 821-824. PMID 9580552 DOI: 10.1038/33934  0.478
1998 Papapetropoulos A, Piccardoni P, Cirino G, Bucci M, Sorrentino R, Cicala C, Johnson K, Zachariou V, Sessa WC, Altieri DC. Hypotension and inflammatory cytokine gene expression triggered by factor Xa-nitric oxide signaling. Proceedings of the National Academy of Sciences of the United States of America. 95: 4738-42. PMID 9539808 DOI: 10.1073/Pnas.95.8.4738  0.4
1998 Rudic RD, Shesely EG, Maeda N, Smithies O, Segal SS, Sessa WC. Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling. The Journal of Clinical Investigation. 101: 731-6. PMID 9466966 DOI: 10.1172/Jci1699  0.777
1997 Papapetropoulos A, García-Cardeña G, Madri JA, Sessa WC. Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells. The Journal of Clinical Investigation. 100: 3131-9. PMID 9399960 DOI: 10.1172/Jci119868  0.484
1997 Shah V, Haddad FG, Garcia-Cardena G, Frangos JA, Mennone A, Groszmann RJ, Sessa WC. Liver sinusoidal endothelial cells are responsible for nitric oxide modulation of resistance in the hepatic sinusoids Journal of Clinical Investigation. 100: 2923-2930. PMID 9389760 DOI: 10.1172/Jci119842  0.389
1997 Caulin-Glaser T, García-Cardeña G, Sarrel P, Sessa WC, Bender JR. 17 beta-estradiol regulation of human endothelial cell basal nitric oxide release, independent of cytosolic Ca2+ mobilization. Circulation Research. 81: 885-92. PMID 9351464 DOI: 10.1161/01.Res.81.5.885  0.379
1997 García-Cardeña G, Martasek P, Masters BS, Skidd PM, Couet J, Li S, Lisanti MP, Sessa WC. Dissecting the interaction between nitric oxide synthase (NOS) and caveolin. Functional significance of the nos caveolin binding domain in vivo. The Journal of Biological Chemistry. 272: 25437-40. PMID 9325253 DOI: 10.1074/Jbc.272.41.25437  0.449
1997 Liu J, Hughes TE, Sessa WC. The first 35 amino acids and fatty acylation sites determine the molecular targeting of endothelial nitric oxide synthase into the Golgi region of cells: a green fluorescent protein study. The Journal of Cell Biology. 137: 1525-35. PMID 9199168 DOI: 10.1083/Jcb.137.7.1525  0.397
1997 List BM, Klösch B, Völker C, Gorren AC, Sessa WC, Werner ER, Kukovetz WR, Schmidt K, Mayer B. Characterization of bovine endothelial nitric oxide synthase as a homodimer with down-regulated uncoupled NADPH oxidase activity: tetrahydrobiopterin binding kinetics and role of haem in dimerization. The Biochemical Journal. 323: 159-65. PMID 9173876 DOI: 10.1042/Bj3230159  0.347
1997 Papapetropoulos A, Desai KM, Rudic RD, Mayer B, Zhang R, Ruiz-Torres MP, García-Cardeña G, Madri JA, Sessa WC. Nitric oxide synthase inhibitors attenuate transforming-growth-factor-beta 1-stimulated capillary organization in vitro. The American Journal of Pathology. 150: 1835-44. PMID 9137106  0.684
1997 Wheeler MA, Smith SD, García-Cardeña G, Nathan CF, Weiss RM, Sessa WC. Bacterial infection induces nitric oxide synthase in human neutrophils. The Journal of Clinical Investigation. 99: 110-6. PMID 9011564 DOI: 10.1172/Jci119121  0.365
1996 García-Cardeña G, Fan R, Stern DF, Liu J, Sessa WC. Endothelial nitric oxide synthase is regulated by tyrosine phosphorylation and interacts with caveolin-1. The Journal of Biological Chemistry. 271: 27237-40. PMID 8910295 DOI: 10.1074/Jbc.271.44.27237  0.455
1996 Liu J, García-Cardeña G, Sessa WC. Palmitoylation of endothelial nitric oxide synthase is necessary for optimal stimulated release of nitric oxide: implications for caveolae localization. Biochemistry. 35: 13277-81. PMID 8873592 DOI: 10.1021/Bi961720E  0.401
1996 Reid SN, Daw NW, Czepita D, Flavin HJ, Sessa WC. Inhibition of nitric oxide synthase does not alter ocular dominance shifts in kitten visual cortex. The Journal of Physiology. 494: 511-7. PMID 8842008 DOI: 10.1113/Jphysiol.1996.Sp021509  0.308
1996 García-Cardeña G, Oh P, Liu J, Schnitzer JE, Sessa WC. Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: implications for nitric oxide signaling. Proceedings of the National Academy of Sciences of the United States of America. 93: 6448-53. PMID 8692835 DOI: 10.1073/Pnas.93.13.6448  0.443
1996 Martasek P, Liu Q, Liu J, Roman LJ, Gross SS, Sessa WC, Masters BSS. Characterization of bovine endothelial nitric oxide synthase expressed in E. coli Biochemical and Biophysical Research Communications. 219: 359-365. PMID 8604992 DOI: 10.1006/Bbrc.1996.0238  0.35
1996 Smith CJ, Sun D, Hoegler C, Roth BS, Zhang X, Zhao G, Xu XB, Kobari Y, Pritchard K, Sessa WC, Hintze TH. Reduced gene expression of vascular endothelial NO synthase and cyclooxygenase-1 in heart failure. Circulation Research. 78: 58-64. PMID 8603506 DOI: 10.1161/01.Res.78.1.58  0.345
1996 Du W, Wang X, Sessa W, Yano Y, Sumpio B. Cyclic strain regulation of endothelial cell biology: Genes, signals & functions Cardiovascular Pathology. 5: 288. DOI: 10.1016/1054-8807(96)80366-8  0.364
1995 Liu J, García-Cardeña G, Sessa WC. Biosynthesis and palmitoylation of endothelial nitric oxide synthase: mutagenesis of palmitoylation sites, cysteines-15 and/or -26, argues against depalmitoylation-induced translocation of the enzyme. Biochemistry. 34: 12333-40. PMID 7547976 DOI: 10.1021/Bi00038A029  0.365
1995 Awolesi MA, Sessa WC, Sumpio BE. Cyclic strain upregulates nitric oxide synthase in cultured bovine aortic endothelial cells. The Journal of Clinical Investigation. 96: 1449-54. PMID 7544806 DOI: 10.1172/Jci118181  0.347
1995 Pritchard KA, Groszek L, Smalley DM, Sessa WC, Wu M, Villalon P, Wolin MS, Stemerman MB. Native low-density lipoprotein increases endothelial cell nitric oxide synthase generation of superoxide anion Circulation Research. 77: 510-518. PMID 7543827 DOI: 10.1161/01.Res.77.3.510  0.364
1995 Sessa WC, García-Cardeña G, Liu J, Keh A, Pollock JS, Bradley J, Thiru S, Braverman IM, Desai KM. The Golgi association of endothelial nitric oxide synthase is necessary for the efficient synthesis of nitric oxide. The Journal of Biological Chemistry. 270: 17641-4. PMID 7543089 DOI: 10.1074/Jbc.270.30.17641  0.464
1995 Zhang R, Min W, Sessa WC. Functional analysis of the human endothelial nitric oxide synthase promoter. Sp1 and GATA factors are necessary for basal transcription in endothelial cells. The Journal of Biological Chemistry. 270: 15320-6. PMID 7541039 DOI: 10.1074/Jbc.270.25.15320  0.332
1995 SHEN W, ZHANG X, ZHAO G, WOLIN MS, SESSA W, HINTZE TH. Nitric oxide production and NO synthase gene expression contribute to vascular regulation during exercise Medicine & Science in Sports & Exercise. 27: 1125???1134. DOI: 10.1249/00005768-199508000-00005  0.387
1994 Rosenkranz-Weiss P, Sessa WC, Milstien S, Kaufman S, Watson CA, Pober JS. Regulation of Nitric Oxide Synthesis by Proinflammatory Cytokines in Human Umbilical Vein Endothelial Cells: Elevations in Tetrahydrobiopterin Levels Enhance Endothelial Nitric Oxide Synthase Specific Activity Journal of Clinical Investigation. 93: 2236-2243. PMID 7514193 DOI: 10.1172/Jci117221  0.42
1994 Sessa WC. The nitric oxide synthase family of proteins. Journal of Vascular Research. 31: 131-43. PMID 7511942 DOI: 10.1159/000159039  0.391
1994 Sessa WC, Pritchard K, Seyedi N, Wang J, Hintze TH. Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression. Circulation Research. 74: 349-53. PMID 7507417 DOI: 10.1161/01.Res.74.2.349  0.339
1993 Escalante B, Omata K, Sessa W, Lee SG, Falck JR, Schwartzman ML. 20-Hydroxyeicosatetraenoic acid is an endothelium-dependent vasoconstrictor in rabbit arteries European Journal of Pharmacology. 235: 1-7. PMID 8519270 DOI: 10.1016/0014-2999(93)90812-V  0.381
1993 Sessa WC, Harrison JK, Luthin DR, Pollock JS, Lynch KR. Genomic analysis and expression patterns reveal distinct genes for endothelial and brain nitric oxide synthase. Hypertension (Dallas, Tex. : 1979). 21: 934-8. PMID 7685005 DOI: 10.1161/01.Hyp.21.6.934  0.345
1993 Sessa WC, Barber CM, Lynch KR. Mutation of N-myristoylation site converts endothelial cell nitric oxide synthase from a membrane to a cytosolic protein Circulation Research. 72: 921-924. PMID 7680289 DOI: 10.1161/01.Res.72.4.921  0.346
1992 Hecker M, Siegle I, MacArthur H, Sessa WC, Vane JR. Role of intracellular thiols in release of EDRF from cultured endothelial cells American Journal of Physiology - Heart and Circulatory Physiology. 262. PMID 1558197 DOI: 10.1152/Ajpheart.1992.262.3.H888  0.371
1991 Hecker M, Mitchell JA, Swierkosz TA, Sessa WC, Vane JR. Inhibition by L-glutamine of the release of endothelium-derived relaxing factor from cultured endothelial cells. British Journal of Pharmacology. 101: 237-9. PMID 2257431 DOI: 10.1111/J.1476-5381.1990.Tb12693.X  0.307
1991 Pagano PJ, Lin L, Sessa WC, Nasjletti A. Arachidonic acid elicits endothelium-dependent release from the rabbit aorta of a constrictor prostanoid resembling prostaglandin endoperoxides. Circulation Research. 69: 396-405. PMID 1907227 DOI: 10.1161/01.Res.69.2.396  0.605
1991 Desai KM, Zembowicz A, Sessa WC, Vane JR. Nitroxergic nerves mediate vagally induced relaxation in the isolated stomach of the guinea pig. Proceedings of the National Academy of Sciences of the United States of America. 88: 11490-4. PMID 1684865 DOI: 10.1073/Pnas.88.24.11490  0.304
1991 Hecker M, Sessa WC, Mitchell JA, Änggård EE, Vane JR. The Biosynthesis of Endothelium-Derived Relaxing Factor by Endothelial Cells as a Means of Removing Excess Nitrogen Journal of Cardiovascular Pharmacology. 17: S19-S24. DOI: 10.1097/00005344-199117003-00005  0.338
1990 Sessa WC, Nasjletti A. Dexamethasone selectively attenuates prostanoid-induced vasoconstrictor responses in vitro. Circulation Research. 66: 383-8. PMID 2297809 DOI: 10.1161/01.Res.66.2.383  0.604
1990 Hecker M, Sessa WC, Harris HJ, Anggård EE, Vane JR. The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: cultured endothelial cells recycle L-citrulline to L-arginine. Proceedings of the National Academy of Sciences of the United States of America. 87: 8612-6. PMID 2236071 DOI: 10.1073/Pnas.87.21.8612  0.307
1990 Sessa WC, Halushka PV, Okwu A, Nasjletti A. Characterization of the vascular thromboxane A2/prostaglandin endoperoxide receptor in rabbit aorta. Regulation by dexamethasone. Circulation Research. 67: 1562-9. PMID 2147131 DOI: 10.1161/01.Res.67.6.1562  0.607
1990 Sessa WC, Lin L, Nasjletti A. Reciprocal effects of dexamethasone on vasodilatory responses to arachidonic acid and prostanoids in the isolated perfused rabbit kidney. Hypertension (Dallas, Tex. : 1979). 15: I93-6. PMID 2105268 DOI: 10.1161/01.Hyp.15.2_Suppl.I93  0.535
1990 Escalante B, Sessa WC, Falck JR, Yadagiri P, Schwartzman ML. Cytochrome P450-dependent arachidonic acid metabolites, 19- and 20-hydroxyeicosatetraenoic acids, enhance sodium-potassium ATPase activity in vascular smooth muscle Journal of Cardiovascular Pharmacology. 16: 438-443. PMID 1700215 DOI: 10.1097/00005344-199009000-00013  0.337
1987 Mullane K, Hatala MA, Kraemer R, Sessa W, Westlin W. Myocardial salvage induced by REV-5901: an inhibitor and antagonist of the leukotrienes. Journal of Cardiovascular Pharmacology. 10: 398-406. PMID 2444792 DOI: 10.1097/00005344-198710000-00004  0.31
1985 Rodgers RL, Breault PH, Sessa WC, Chichester CO. Depressor effect of diabetes in spontaneously hypertensive rat: role of vascular reactivity and prolyl hydroxylase and lysyl oxidase activities. Life Sciences. 37: 2237-47. PMID 2866437 DOI: 10.1016/0024-3205(85)90014-1  0.305
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