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William C. Sessa - Publications

Yale University, New Haven, CT 
Vascular Biology

93 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Park H, Furtado J, Poulet M, Chung M, Yun S, Lee S, Sessa WC, Franco CA, Schwartz MA, Eichmann A. Defective Flow-Migration Coupling Causes Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia. Circulation. PMID 34182767 DOI: 10.1161/CIRCULATIONAHA.120.053047  0.3
2020 Garcia V, Park EJ, Siragusa M, Frohlich F, Haque MM, Pascale JV, Heberlein KR, Isakson BE, Stuehr DJ, Sessa WC. Unbiased proteomics identifies plasminogen activator inhibitor-1 as a negative regulator of endothelial nitric oxide synthase. Proceedings of the National Academy of Sciences of the United States of America. PMID 32300005 DOI: 10.1073/Pnas.1918761117  0.303
2018 Garcia V, Sessa WC. Endothelial Nitric Oxide Synthase (eNOS): Perspective and Recent Developments. British Journal of Pharmacology. PMID 30341769 DOI: 10.1111/Bph.14522  0.305
2018 Ola R, Künzel SH, Zhang F, Genet G, Chakraborty R, Pibouin-Fragner L, Martin K, Sessa W, Dubrac A, Eichmann A. SMAD4 Prevents Flow Induced Arterial-Venous Malformations by Inhibiting Casein Kinase 2. Circulation. PMID 29976569 DOI: 10.1161/Circulationaha.118.033842  0.31
2017 Jiang Y, Lin X, Tang Z, Lee C, Tian G, Du Y, Yin X, Ren X, Huang L, Ye Z, Chen W, Zhang F, Mi J, Gao Z, Wang S, ... ... Sessa WC, et al. Critical role of caveolin-1 in ocular neovascularization and multitargeted antiangiogenic effects of cavtratin via JNK. Proceedings of the National Academy of Sciences of the United States of America. PMID 28923916 DOI: 10.1073/Pnas.1706394114  0.304
2017 Kraehling JR, Sessa WC. Contemporary Approaches to Modulating the Nitric Oxide-cGMP Pathway in Cardiovascular Disease. Circulation Research. 120: 1174-1182. PMID 28360348 DOI: 10.1161/Circresaha.117.303776  0.33
2016 Park EJ, Grabińska KA, Guan Z, Sessa WC. NgBR is essential for endothelial cell glycosylation and vascular development. Embo Reports. PMID 26755743 DOI: 10.15252/Embr.201540789  0.315
2015 Siragusa M, Fröhlich F, Park EJ, Schleicher M, Walther TC, Sessa WC. Stromal cell-derived factor 2 is critical for Hsp90-dependent eNOS activation. Science Signaling. 8: ra81. PMID 26286023 DOI: 10.1126/Scisignal.Aaa2819  0.337
2014 Lee MY, Luciano AK, Ackah E, Rodriguez-Vita J, Bancroft TA, Eichmann A, Simons M, Kyriakides TR, Morales-Ruiz M, Sessa WC. Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates. Proceedings of the National Academy of Sciences of the United States of America. 111: 12865-70. PMID 25136137 DOI: 10.1073/Pnas.1408472111  0.824
2014 Mehra VC, Jackson E, Zhang XM, Jiang XC, Dobrucki LW, Yu J, Bernatchez P, Sinusas AJ, Shulman GI, Sessa WC, Yarovinsky TO, Bender JR. Ceramide-activated phosphatase mediates fatty acid-induced endothelial VEGF resistance and impaired angiogenesis. The American Journal of Pathology. 184: 1562-76. PMID 24606881 DOI: 10.1016/J.Ajpath.2014.01.009  0.337
2014 Jozsef L, Tashiro K, Kuo A, Park EJ, Skoura A, Albinsson S, Rivera-Molina F, Harrison KD, Iwakiri Y, Toomre D, Sessa WC. Reticulon 4 is necessary for endoplasmic reticulum tubulation, STIM1-Orai1 coupling, and store-operated calcium entry. The Journal of Biological Chemistry. 289: 9380-95. PMID 24558039 DOI: 10.1074/Jbc.M114.548602  0.756
2014 Ju R, Zhuang ZW, Zhang J, Lanahan AA, Kyriakides T, Sessa WC, Simons M. Angiopoietin-2 secretion by endothelial cell exosomes: Regulation by the phosphatidylinositol 3-kinase (PI3K)/Akt/endothelial nitric oxide synthase (eNOS) and syndecan-4/syntenin pathways Journal of Biological Chemistry. 289: 510-519. PMID 24235146 DOI: 10.1074/Jbc.M113.506899  0.347
2013 Di Lorenzo A, Lin MI, Murata T, Landskroner-Eiger S, Schleicher M, Kothiya M, Iwakiri Y, Yu J, Huang PL, Sessa WC. eNOS-derived nitric oxide regulates endothelial barrier function through VE-cadherin and Rho GTPases. Journal of Cell Science. 126: 5541-52. PMID 24046447 DOI: 10.1242/Jcs.115972  0.717
2012 Sangwung P, Greco TM, Wang Y, Ischiropoulos H, Sessa WC, Iwakiri Y. Proteomic identification of S-nitrosylated Golgi proteins: new insights into endothelial cell regulation by eNOS-derived NO. Plos One. 7: e31564. PMID 22363674 DOI: 10.1371/Journal.Pone.0031564  0.303
2012 Yu J, Zhang Y, Zhang X, Rudic RD, Bauer PM, Altieri DC, Sessa WC. Endothelium derived nitric oxide synthase negatively regulates the PDGF-survivin pathway during flow-dependent vascular remodeling. Plos One. 7: e31495. PMID 22355372 DOI: 10.1371/Journal.Pone.0031495  0.738
2012 Förstermann U, Sessa WC. Nitric oxide synthases: regulation and function. European Heart Journal. 33: 829-37, 837a-837d. PMID 21890489 DOI: 10.1093/Eurheartj/Ehr304  0.309
2011 MacLauchlan S, Yu J, Parrish M, Asoulin TA, Schleicher M, Krady MM, Zeng J, Huang PL, Sessa WC, Kyriakides TR. Endothelial nitric oxide synthase controls the expression of the angiogenesis inhibitor thrombospondin 2. Proceedings of the National Academy of Sciences of the United States of America. 108: E1137-45. PMID 21949402 DOI: 10.1073/Pnas.1104357108  0.319
2011 Sutendra G, Dromparis P, Wright P, Bonnet S, Haromy A, Hao Z, McMurtry MS, Michalak M, Vance JE, Sessa WC, Michelakis ED. The role of Nogo and the mitochondria-endoplasmic reticulum unit in pulmonary hypertension. Science Translational Medicine. 3: 88ra55. PMID 21697531 DOI: 10.1126/Scitranslmed.3002194  0.75
2011 Harrison KD, Park EJ, Gao N, Kuo A, Rush JS, Waechter CJ, Lehrman MA, Sessa WC. Nogo-B receptor is necessary for cellular dolichol biosynthesis and protein N-glycosylation. The Embo Journal. 30: 2490-500. PMID 21572394 DOI: 10.1038/Emboj.2011.147  0.765
2011 Muto A, Yi T, Harrison KD, Dávalos A, Fancher TT, Ziegler KR, Feigel A, Kondo Y, Nishibe T, Sessa WC, Dardik A. Eph-B4 prevents venous adaptive remodeling in the adult arterial environment. The Journal of Experimental Medicine. 208: 561-75. PMID 21339325 DOI: 10.1084/Jem.20101854  0.792
2011 Di Lorenzo A, Manes TD, Davalos A, Wright PL, Sessa WC. Endothelial reticulon-4B (Nogo-B) regulates ICAM-1-mediated leukocyte transmigration and acute inflammation. Blood. 117: 2284-95. PMID 21183689 DOI: 10.1182/Blood-2010-04-281956  0.786
2010 Wright PL, Yu J, Di YP, Homer RJ, Chupp G, Elias JA, Cohn L, Sessa WC. Epithelial reticulon 4B (Nogo-B) is an endogenous regulator of Th2-driven lung inflammation. The Journal of Experimental Medicine. 207: 2595-607. PMID 20975041 DOI: 10.1084/Jem.20100786  0.744
2010 Marin EP, Moeckel G, Al-Lamki R, Bradley J, Yan Q, Wang T, Wright PL, Yu J, Sessa WC. Identification and regulation of reticulon 4B (Nogo-B) in renal tubular epithelial cells. The American Journal of Pathology. 177: 2765-73. PMID 20971739 DOI: 10.2353/Ajpath.2010.100199  0.753
2010 Dávalos A, Fernández-Hernando C, Sowa G, Derakhshan B, Lin MI, Lee JY, Zhao H, Luo R, Colangelo C, Sessa WC. Quantitative proteomics of caveolin-1-regulated proteins: characterization of polymerase i and transcript release factor/CAVIN-1 IN endothelial cells. Molecular & Cellular Proteomics : McP. 9: 2109-24. PMID 20585024 DOI: 10.1074/Mcp.M110.001289  0.703
2010 Fernández-Hernando C, Yu J, Dávalos A, Prendergast J, Sessa WC. Endothelial-specific overexpression of caveolin-1 accelerates atherosclerosis in apolipoprotein E-deficient mice. The American Journal of Pathology. 177: 998-1003. PMID 20581061 DOI: 10.2353/Ajpath.2010.091287  0.303
2010 Muto A, Yi T, Harrison K, Davalos A, Sessa WC, Dardik A. SS6. Venous Specific Eph-B4 Regulates Vein Graft Thickening via Caveolin-1 Journal of Vascular Surgery. 51: 6S-7S. DOI: 10.1016/J.Jvs.2010.02.046  0.761
2009 Yu J, Fernández-Hernando C, Suarez Y, Schleicher M, Hao Z, Wright PL, DiLorenzo A, Kyriakides TR, Sessa WC. Reticulon 4B (Nogo-B) is necessary for macrophage infiltration and tissue repair. Proceedings of the National Academy of Sciences of the United States of America. 106: 17511-6. PMID 19805174 DOI: 10.1073/Pnas.0907359106  0.767
2009 Harrison KD, Miao RQ, Fernandez-Hernándo C, Suárez Y, Dávalos A, Sessa WC. Nogo-B receptor stabilizes Niemann-Pick type C2 protein and regulates intracellular cholesterol trafficking. Cell Metabolism. 10: 208-18. PMID 19723497 DOI: 10.1016/J.Cmet.2009.07.003  0.775
2009 Schleicher M, Yu J, Murata T, Derakhshan B, Atochin D, Qian L, Kashiwagi S, Di Lorenzo A, Harrison KD, Huang PL, Sessa WC. The Akt1-eNOS axis illustrates the specificity of kinase-substrate relationships in vivo Science Signaling. 2: ra41. PMID 19654415 DOI: 10.1126/Scisignal.2000343  0.802
2009 Di Lorenzo A, Fernández-Hernando C, Cirino G, Sessa WC. Akt1 is critical for acute inflammation and histamine-mediated vascular leakage. Proceedings of the National Academy of Sciences of the United States of America. 106: 14552-7. PMID 19622728 DOI: 10.1073/Pnas.0904073106  0.317
2009 Fernández-Hernando C, Yu J, Suárez Y, Rahner C, Dávalos A, Lasunción MA, Sessa WC. Genetic evidence supporting a critical role of endothelial caveolin-1 during the progression of atherosclerosis. Cell Metabolism. 10: 48-54. PMID 19583953 DOI: 10.1016/J.Cmet.2009.06.003  0.309
2009 Chidlow JH, Greer JJ, Anthoni C, Bernatchez P, Fernandez-Hernando C, Fernadez-Hernando C, Bruce M, Abdelbaqi M, Shukla D, Granger DN, Sessa WC, Kevil CG. Endothelial caveolin-1 regulates pathologic angiogenesis in a mouse model of colitis. Gastroenterology. 136: 575-84.e2. PMID 19111727 DOI: 10.1053/J.Gastro.2008.10.085  0.302
2008 Murata T, Lin MI, Aritake K, Matsumoto S, Narumiya S, Ozaki H, Urade Y, Hori M, Sessa WC. Role of prostaglandin D2 receptor DP as a suppressor of tumor hyperpermeability and angiogenesis in vivo. Proceedings of the National Academy of Sciences of the United States of America. 105: 20009-14. PMID 19060214 DOI: 10.1073/Pnas.0805171105  0.697
2008 Zhang H, He Y, Dai S, Xu Z, Luo Y, Wan T, Luo D, Jones D, Tang S, Chen H, Sessa WC, Min W. AIP1 functions as an endogenous inhibitor of VEGFR2-mediated signaling and inflammatory angiogenesis in mice. The Journal of Clinical Investigation. 118: 3904-16. PMID 19033661 DOI: 10.1172/Jci36168  0.32
2008 Kritz AB, Yu J, Wright PL, Wan S, George SJ, Halliday C, Kang N, Sessa WC, Baker AH. In vivo modulation of Nogo-B attenuates neointima formation. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 1798-804. PMID 18781142 DOI: 10.1038/Mt.2008.188  0.757
2008 Suárez Y, Fernández-Hernando C, Yu J, Gerber SA, Harrison KD, Pober JS, Iruela-Arispe ML, Merkenschlager M, Sessa WC. Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis. Proceedings of the National Academy of Sciences of the United States of America. 105: 14082-7. PMID 18779589 DOI: 10.1073/Pnas.0804597105  0.784
2008 Derakhshan B, Harrison KD, Miao QR, Sessa WC. Chapter 1 Approaches for Studying Angiogenesis-Related Signal Transduction Methods in Enzymology. 443: 1-23. PMID 18772008 DOI: 10.1016/S0076-6879(08)02001-6  0.803
2008 Schleicher M, Sessa WC. Are the mechanisms for NO-dependent vascular remodeling different from vasorelaxation in vivo? Arteriosclerosis, Thrombosis, and Vascular Biology. 28: 1207-8. PMID 18565841 DOI: 10.1161/Atvbaha.108.167403  0.337
2008 Schleicher M, Shepherd BR, Suarez Y, Fernandez-Hernando C, Yu J, Pan Y, Acevedo LM, Shadel GS, Sessa WC. Prohibitin-1 maintains the angiogenic capacity of endothelial cells by regulating mitochondrial function and senescence. The Journal of Cell Biology. 180: 101-12. PMID 18195103 DOI: 10.1083/Jcb.200706072  0.765
2008 Miao RQ, Fontana J, Fulton D, Lin MI, Harrison KD, Sessa WC. Dominant-negative Hsp90 reduces VEGF-stimulated nitric oxide release and migration in endothelial cells. Arteriosclerosis, Thrombosis, and Vascular Biology. 28: 105-11. PMID 17975117 DOI: 10.1161/Atvbaha.107.155499  0.789
2007 Fernández-Hernando C, Ackah E, Yu J, Suárez Y, Murata T, Iwakiri Y, Prendergast J, Miao RQ, Birnbaum MJ, Sessa WC. Loss of Akt1 leads to severe atherosclerosis and occlusive coronary artery disease. Cell Metabolism. 6: 446-57. PMID 18054314 DOI: 10.1016/J.Cmet.2007.10.007  0.808
2007 Murata T, Lin MI, Huang Y, Yu J, Bauer PM, Giordano FJ, Sessa WC. Reexpression of caveolin-1 in endothelium rescues the vascular, cardiac, and pulmonary defects in global caveolin-1 knockout mice. The Journal of Experimental Medicine. 204: 2373-82. PMID 17893196 DOI: 10.1084/Jem.20062340  0.705
2007 Bernatchez PN, Acevedo L, Fernandez-Hernando C, Murata T, Chalouni C, Kim J, Erdjument-Bromage H, Shah V, Gratton JP, McNally EM, Tempst P, Sessa WC. Myoferlin regulates vascular endothelial growth factor receptor-2 stability and function. The Journal of Biological Chemistry. 282: 30745-53. PMID 17702744 DOI: 10.1074/Jbc.M704798200  0.782
2007 Murata T, Lin MI, Stan RV, Bauer PM, Yu J, Sessa WC. Genetic evidence supporting caveolae microdomain regulation of calcium entry in endothelial cells. The Journal of Biological Chemistry. 282: 16631-43. PMID 17416589 DOI: 10.1074/Jbc.M607948200  0.684
2007 Lin MI, Yu J, Murata T, Sessa WC. Caveolin-1-deficient mice have increased tumor microvascular permeability, angiogenesis, and growth. Cancer Research. 67: 2849-56. PMID 17363608 DOI: 10.1158/0008-5472.Can-06-4082  0.687
2007 Pyriochou A, Zhou Z, Koika V, Petrou C, Cordopatis P, Sessa WC, Papapetropoulos A. The phosphodiesterase 5 inhibitor sildenafil stimulates angiogenesis through a protein kinase G/MAPK pathway. Journal of Cellular Physiology. 211: 197-204. PMID 17226792 DOI: 10.1002/Jcp.20929  0.305
2006 Luo D, Luo Y, He Y, Zhang H, Zhang R, Li X, Dobrucki WL, Sinusas AJ, Sessa WC, Min W. Differential functions of tumor necrosis factor receptor 1 and 2 signaling in ischemia-mediated arteriogenesis and angiogenesis. The American Journal of Pathology. 169: 1886-98. PMID 17071609 DOI: 10.2353/Ajpath.2006.060603  0.344
2006 Lin MI, Sessa WC. Vascular endothelial growth factor signaling to endothelial nitric oxide synthase: more than a FLeeTing moment. Circulation Research. 99: 666-8. PMID 17008595 DOI: 10.1161/01.Res.0000245430.24075.A4  0.718
2006 Phung TL, Ziv K, Dabydeen D, Eyiah-Mensah G, Riveros M, Perruzzi C, Sun J, Monahan-Earley RA, Shiojima I, Nagy JA, Lin MI, Walsh K, Dvorak AM, Briscoe DM, Neeman M, ... Sessa WC, et al. Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin Cancer Cell. 10: 159-170. PMID 16904613 DOI: 10.1016/J.Ccr.2006.07.003  0.694
2006 Fernández-Hernando C, Fukata M, Bernatchez PN, Fukata Y, Lin MI, Bredt DS, Sessa WC. Identification of Golgi-localized acyl transferases that palmitoylate and regulate endothelial nitric oxide synthase. The Journal of Cell Biology. 174: 369-77. PMID 16864653 DOI: 10.1083/Jcb.200601051  0.705
2006 Miao RQ, Gao Y, Harrison KD, Prendergast J, Acevedo LM, Yu J, Hu F, Strittmatter SM, Sessa WC. Identification of a receptor necessary for Nogo-B stimulated chemotaxis and morphogenesis of endothelial cells. Proceedings of the National Academy of Sciences of the United States of America. 103: 10997-1002. PMID 16835300 DOI: 10.1073/Pnas.0602427103  0.793
2006 Bhandari V, Choo-Wing R, Chapoval SP, Lee CG, Tang C, Kim YK, Ma B, Baluk P, Lin MI, McDonald DM, Homer RJ, Sessa WC, Elias JA. Essential role of nitric oxide in VEGF-induced, asthma-like angiogenic, inflammatory, mucus, and physiologic responses in the lung. Proceedings of the National Academy of Sciences of the United States of America. 103: 11021-6. PMID 16832062 DOI: 10.1073/Pnas.0601057103  0.716
2006 Hatakeyama T, Pappas PJ, Hobson RW, Boric MP, Sessa WC, Durán WN. Endothelial nitric oxide synthase regulates microvascular hyperpermeability in vivo. The Journal of Physiology. 574: 275-81. PMID 16675496 DOI: 10.1113/Jphysiol.2006.108175  0.324
2006 Yu J, Bergaya S, Murata T, Alp IF, Bauer MP, Lin MI, Drab M, Kurzchalia TV, Stan RV, Sessa WC. Direct evidence for the role of caveolin-1 and caveolae in mechanotransduction and remodeling of blood vessels. The Journal of Clinical Investigation. 116: 1284-91. PMID 16670769 DOI: 10.1172/Jci27100  0.7
2006 Fernández C, Fukata M, Bernatchez P, Fukata Y, Lin M, Bredt DS, Sessa WC. O08. Identification of Golgi localized acyl transferases that palmitoylate and regulate endothelial nitric oxide synthase Nitric Oxide. 14: 3. DOI: 10.1016/J.Niox.2006.04.012  0.632
2005 Partovian C, Zhuang Z, Moodie K, Lin M, Ouchi N, Sessa WC, Walsh K, Simons M. PKCalpha activates eNOS and increases arterial blood flow in vivo. Circulation Research. 97: 482-7. PMID 16081872 DOI: 10.1161/01.Res.0000179775.04114.45  0.719
2005 Ackah E, Yu J, Zoellner S, Iwakiri Y, Skurk C, Shibata R, Ouchi N, Easton RM, Galasso G, Birnbaum MJ, Walsh K, Sessa WC. Akt1/protein kinase Balpha is critical for ischemic and VEGF-mediated angiogenesis. The Journal of Clinical Investigation. 115: 2119-27. PMID 16075056 DOI: 10.1172/Jci24726  0.823
2005 Yu J, deMuinck ED, Zhuang Z, Drinane M, Kauser K, Rubanyi GM, Qian HS, Murata T, Escalante B, Sessa WC. Endothelial nitric oxide synthase is critical for ischemic remodeling, mural cell recruitment, and blood flow reserve. Proceedings of the National Academy of Sciences of the United States of America. 102: 10999-1004. PMID 16043715 DOI: 10.1073/Pnas.0501444102  0.318
2005 Bucci M, Roviezzo F, Posadas I, Yu J, Parente L, Sessa WC, Ignarro LJ, Cirino G. Endothelial nitric oxide synthase activation is critical for vascular leakage during acute inflammation in vivo Proceedings of the National Academy of Sciences of the United States of America. 102: 904-908. PMID 15640348 DOI: 10.1073/Pnas.0408906102  0.336
2005 Bauer PM, Yu J, Chen Y, Hickey R, Bernatchez PN, Looft-Wilson R, Huang Y, Giordano F, Stan RV, Sessa WC. Endothelial-specific expression of caveolin-1 impairs microvascular permeability and angiogenesis. Proceedings of the National Academy of Sciences of the United States of America. 102: 204-9. PMID 15615855 DOI: 10.1073/Pnas.0406092102  0.361
2004 Lin MI, Sessa WC. Antiangiogenic therapy: creating a unique "window" of opportunity. Cancer Cell. 6: 529-31. PMID 15607955 DOI: 10.1016/J.Ccr.2004.12.003  0.638
2004 Hagendoorn J, Padera TP, Kashiwagi S, Isaka N, Noda F, Lin MI, Huang PL, Sessa WC, Fukumura D, Jain RK. Endothelial nitric oxide synthase regulates microlymphatic flow via collecting lymphatics. Circulation Research. 95: 204-9. PMID 15192027 DOI: 10.1161/01.Res.0000135549.72828.24  0.7
2004 Fulton D, Babbitt R, Zoellner S, Fontana J, Acevedo L, McCabe TJ, Iwakiri Y, Sessa WC. Targeting of endothelial nitric-oxide synthase to the cytoplasmic face of the Golgi complex or plasma membrane regulates Akt- versus calcium-dependent mechanisms for nitric oxide release. The Journal of Biological Chemistry. 279: 30349-57. PMID 15136572 DOI: 10.1074/Jbc.M402155200  0.783
2004 Acevedo L, Yu J, Erdjument-Bromage H, Miao RQ, Kim JE, Fulton D, Tempst P, Strittmatter SM, Sessa WC. A new role for Nogo as a regulator of vascular remodeling. Nature Medicine. 10: 382-8. PMID 15034570 DOI: 10.1038/Nm1020  0.779
2004 Bucci M, Roviezzo F, Brancaleone V, Lin MI, Di Lorenzo A, Cicala C, Pinto A, Sessa WC, Farneti S, Fiorucci S, Cirino G. Diabetic mouse angiopathy is linked to progressive sympathetic receptor deletion coupled to an enhanced caveolin-1 expression. Arteriosclerosis, Thrombosis, and Vascular Biology. 24: 721-6. PMID 14962949 DOI: 10.1161/01.Atv.0000122362.44628.09  0.659
2004 Papapetropoulos A, Fulton D, Lin MI, Fontana J, McCabe TJ, Zoellner S, García-Cardeña G, Zhou Z, Gratton JP, Sessa WC. Vanadate is a potent activator of endothelial nitric-oxide synthase: evidence for the role of the serine/threonine kinase Akt and the 90-kDa heat shock protein. Molecular Pharmacology. 65: 407-15. PMID 14742683 DOI: 10.1124/Mol.65.2.407  0.814
2004 Ou J, Fontana JT, Ou Z, Jones DW, Ackerman AW, Oldham KT, Yu J, Sessa WC, Pritchard KA. Heat shock protein 90 and tyrosine kinase regulate eNOS NO* generation but not NO* bioactivity. American Journal of Physiology. Heart and Circulatory Physiology. 286: H561-9. PMID 14551044 DOI: 10.1152/Ajpheart.00736.2003  0.793
2003 Fortugno P, Beltrami E, Plescia J, Fontana J, Pradhan D, Marchisio PC, Sessa WC, Altieri DC. Regulation of survivin function by Hsp90. Proceedings of the National Academy of Sciences of the United States of America. 100: 13791-6. PMID 14614132 DOI: 10.1073/Pnas.2434345100  0.733
2003 Lin MI, Fulton D, Babbitt R, Fleming I, Busse R, Pritchard KA, Sessa WC. Phosphorylation of threonine 497 in endothelial nitric-oxide synthase coordinates the coupling of L-arginine metabolism to efficient nitric oxide production. The Journal of Biological Chemistry. 278: 44719-26. PMID 12952971 DOI: 10.1074/Jbc.M302836200  0.71
2003 Gratton JP, Lin MI, Yu J, Weiss ED, Jiang ZL, Fairchild TA, Iwakiri Y, Groszmann R, Claffey KP, Cheng YC, Sessa WC. Selective inhibition of tumor microvascular permeability by cavtratin blocks tumor progression in mice. Cancer Cell. 4: 31-9. PMID 12892711 DOI: 10.1016/S1535-6108(03)00168-5  0.667
2002 Napoli C, Ackah E, De Nigris F, Del Soldato P, D'Armiento FP, Crimi E, Condorelli M, Sessa WC. Chronic treatment with nitric oxide-releasing aspirin reduces plasma low-density lipoprotein oxidation and oxidative stress, arterial oxidation-specific epitopes, and atherogenesis in hypercholesterolemic mice. Proceedings of the National Academy of Sciences of the United States of America. 99: 12467-70. PMID 12209007 DOI: 10.1073/Pnas.192244499  0.787
2002 Yu J, Rudic RD, Sessa WC. Nitric oxide-releasing aspirin decreases vascular injury by reducing inflammation and promoting apoptosis. Laboratory Investigation; a Journal of Technical Methods and Pathology. 82: 825-32. PMID 12118084 DOI: 10.1097/01.Lab.0000018828.61722.Bd  0.728
2002 Pritchard KA, Ackerman AW, Ou J, Curtis M, Smalley DM, Fontana JT, Stemerman MB, Sessa WC. Native low-density lipoprotein induces endothelial nitric oxide synthase dysfunction: role of heat shock protein 90 and caveolin-1. Free Radical Biology & Medicine. 33: 52-62. PMID 12086682 DOI: 10.1016/S0891-5849(02)00851-1  0.77
2002 Scotland RS, Morales-Ruiz M, Chen Y, Yu J, Rudic RD, Fulton D, Gratton JP, Sessa WC. Functional reconstitution of endothelial nitric oxide synthase reveals the importance of serine 1179 in endothelium-dependent vasomotion. Circulation Research. 90: 904-10. PMID 11988492 DOI: 10.1161/01.Res.0000016506.04193.96  0.739
2002 Fontana J, Fulton D, Chen Y, Fairchild TA, McCabe TJ, Fujita N, Tsuruo T, Sessa WC. Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release. Circulation Research. 90: 866-73. PMID 11988487 DOI: 10.1161/01.Res.0000016837.26733.Be  0.733
2002 Fulton D, Fontana J, Sowa G, Gratton JP, Lin M, Li KX, Michell B, Kemp BE, Rodman D, Sessa WC. Localization of endothelial nitric-oxide synthase phosphorylated on serine 1179 and nitric oxide in Golgi and plasma membrane defines the existence of two pools of active enzyme. The Journal of Biological Chemistry. 277: 4277-84. PMID 11729179 DOI: 10.1074/Jbc.M106302200  0.794
2001 Fairchild TA, Fulton D, Fontana JT, Gratton JP, McCabe TJ, Sessa WC. Acidic hydrolysis as a mechanism for the cleavage of the Glu(298)-->Asp variant of human endothelial nitric-oxide synthase. The Journal of Biological Chemistry. 276: 26674-9. PMID 11331296 DOI: 10.1074/Jbc.M103647200  0.77
2001 Pritchard KA, Ackerman AW, Gross ER, Stepp DW, Shi Y, Fontana JT, Baker JE, Sessa WC. Heat shock protein 90 mediates the balance of nitric oxide and superoxide anion from endothelial nitric-oxide synthase. The Journal of Biological Chemistry. 276: 17621-4. PMID 11278264 DOI: 10.1074/Jbc.C100084200  0.776
2000 Bucci M, Gratton JP, Rudic RD, Acevedo L, Roviezzo F, Cirino G, Sessa WC. In vivo delivery of the caveolin-1 scaffolding domain inhibits nitric oxide synthesis and reduces inflammation. Nature Medicine. 6: 1362-7. PMID 11100121 DOI: 10.1038/82176  0.811
2000 Luo Z, Fujio Y, Kureishi Y, Rudic RD, Daumerie G, Fulton D, Sessa WC, Walsh K. Acute modulation of endothelial Akt/PKB activity alters nitric oxide-dependent vasomotor activity in vivo. The Journal of Clinical Investigation. 106: 493-9. PMID 10953024 DOI: 10.1172/Jci9419  0.735
2000 Rudic RD, Bucci M, Fulton D, Segal SS, Sessa WC. Temporal events underlying arterial remodeling after chronic flow reduction in mice: correlation of structural changes with a deficit in basal nitric oxide synthesis. Circulation Research. 86: 1160-6. PMID 10850968 DOI: 10.1161/01.Res.86.11.1160  0.714
2000 Gratton JP, Fontana J, O'Connor DS, Garcia-Cardena G, McCabe TJ, Sessa WC. Reconstitution of an endothelial nitric-oxide synthase (eNOS), hsp90, and caveolin-1 complex in vitro. Evidence that hsp90 facilitates calmodulin stimulated displacement of eNOS from caveolin-1. The Journal of Biological Chemistry. 275: 22268-72. PMID 10781589 DOI: 10.1074/Jbc.M001644200  0.733
1999 Papapetropoulos A, Rudic RD, Sessa WC. Molecular control of nitric oxide synthases in the cardiovascular system. Cardiovascular Research. 43: 509-20. PMID 10690323 DOI: 10.1016/S0008-6363(99)00161-3  0.697
1999 Fulton D, Gratton JP, McCabe TJ, Fontana J, Fujio Y, Walsh K, Franke TF, Papapetropoulos A, Sessa WC. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature. 399: 597-601. PMID 10376602 DOI: 10.1038/21218  0.733
1999 Rudic RD, Sessa WC. Nitric oxide in endothelial dysfunction and vascular remodeling: clinical correlates and experimental links. American Journal of Human Genetics. 64: 673-7. PMID 10052999 DOI: 10.1086/302304  0.712
1999 Fulton D, Gratton J, McCabe TJ, Fontana J, Fujio Y, Walsh K, Franke TF, Papapetropoulos A, Sessa WC. Erratum: Regulation of endothelium-derived nitric oxide production by the protein kinase Akt Nature. 400: 792-792. DOI: 10.1038/23523  0.733
1998 Rudic RD, Shesely EG, Maeda N, Smithies O, Segal SS, Sessa WC. Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling. The Journal of Clinical Investigation. 101: 731-6. PMID 9466966 DOI: 10.1172/Jci1699  0.74
1997 Papapetropoulos A, García-Cardeña G, Madri JA, Sessa WC. Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells. The Journal of Clinical Investigation. 100: 3131-9. PMID 9399960 DOI: 10.1172/Jci119868  0.311
1997 Papapetropoulos A, Desai KM, Rudic RD, Mayer B, Zhang R, Ruiz-Torres MP, García-Cardeña G, Madri JA, Sessa WC. Nitric oxide synthase inhibitors attenuate transforming-growth-factor-beta 1-stimulated capillary organization in vitro. The American Journal of Pathology. 150: 1835-44. PMID 9137106  0.692
1991 Pagano PJ, Lin L, Sessa WC, Nasjletti A. Arachidonic acid elicits endothelium-dependent release from the rabbit aorta of a constrictor prostanoid resembling prostaglandin endoperoxides. Circulation Research. 69: 396-405. PMID 1907227 DOI: 10.1161/01.Res.69.2.396  0.571
1990 Sessa WC, Nasjletti A. Dexamethasone selectively attenuates prostanoid-induced vasoconstrictor responses in vitro. Circulation Research. 66: 383-8. PMID 2297809 DOI: 10.1161/01.Res.66.2.383  0.566
1990 Sessa WC, Halushka PV, Okwu A, Nasjletti A. Characterization of the vascular thromboxane A2/prostaglandin endoperoxide receptor in rabbit aorta. Regulation by dexamethasone. Circulation Research. 67: 1562-9. PMID 2147131 DOI: 10.1161/01.Res.67.6.1562  0.551
1990 Sessa WC, Lin L, Nasjletti A. Reciprocal effects of dexamethasone on vasodilatory responses to arachidonic acid and prostanoids in the isolated perfused rabbit kidney. Hypertension (Dallas, Tex. : 1979). 15: I93-6. PMID 2105268 DOI: 10.1161/01.Hyp.15.2_Suppl.I93  0.536
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