| Year |
Citation |
Score |
| 2023 |
Buehl CJ, Goff NJ, Mikhova M, Hardwick SW, Blundell TL, Modesti M, Schmidt JC, Chaplin A, Meek K. Unravelling the complexities of DNA-PK activation by structure-based mutagenesis. Research Square. PMID 38168382 DOI: 10.21203/rs.3.rs-3627471/v1 |
0.739 |
|
| 2023 |
Hardwick SW, Stavridi AK, Chirgadze DY, De Oliveira TM, Charbonnier JB, Ropars V, Meek K, Blundell TL, Chaplin AK. Cryo-EM structure of a DNA-PK trimer: higher order oligomerisation in NHEJ. Structure (London, England : 1993). PMID 37311458 DOI: 10.1016/j.str.2023.05.013 |
0.636 |
|
| 2023 |
Seif-El-Dahan M, Kefala-Stavridi A, Frit P, Hardwick SW, Chirgadze DY, Maia De Oliviera T, Britton S, Barboule N, Bossaert M, Pandurangan AP, Meek K, Blundell TL, Ropars V, Calsou P, Charbonnier JB, et al. PAXX binding to the NHEJ machinery explains functional redundancy with XLF. Science Advances. 9: eadg2834. PMID 37256950 DOI: 10.1126/sciadv.adg2834 |
0.614 |
|
| 2023 |
Buehl CJ, Goff NJ, Hardwick SW, Gellert M, Blundell TL, Yang W, Chaplin AK, Meek K. Two distinct long-range synaptic complexes promote different aspects of end processing prior to repair of DNA breaks by non-homologous end joining. Molecular Cell. PMID 36724784 DOI: 10.1016/j.molcel.2023.01.012 |
0.689 |
|
| 2022 |
Goff NJ, Brenière M, Buehl CJ, de Melo AJ, Huskova H, Ochi T, Blundell TL, Mao W, Yu K, Modesti M, Meek K. Catalytically inactive DNA ligase IV promotes DNA repair in living cells. Nucleic Acids Research. PMID 36263813 DOI: 10.1093/nar/gkac913 |
0.702 |
|
| 2021 |
Liu L, Chen X, Li J, Wang H, Buehl CJ, Goff NJ, Meek K, Yang W, Gellert M. Autophosphorylation transforms DNA-PK from protecting to processing DNA ends. Molecular Cell. PMID 34936881 DOI: 10.1016/j.molcel.2021.11.025 |
0.745 |
|
| 2021 |
Chaplin AK, Hardwick SW, Stavridi AK, Buehl CJ, Goff NJ, Ropars V, Liang S, De Oliveira TM, Chirgadze DY, Meek K, Charbonnier JB, Blundell TL. Cryo-EM of NHEJ supercomplexes provides insights into DNA repair. Molecular Cell. PMID 34352203 DOI: 10.1016/j.molcel.2021.07.005 |
0.687 |
|
| 2020 |
Lees-Miller JP, Cobban A, Katsonis P, Bacolla A, Tsutakawa SE, Hammel M, Meek K, Anderson DW, Lichtarge O, Tainer JA, Lees-Miller SP. Uncovering DNA-PKcs ancient phylogeny, unique sequence motifs and insights for human disease. Progress in Biophysics and Molecular Biology. PMID 33035590 DOI: 10.1016/j.pbiomolbio.2020.09.010 |
0.674 |
|
| 2020 |
Meek K. Activation of DNA-PK by hairpinned DNA ends reveals a stepwise mechanism of kinase activation. Nucleic Acids Research. PMID 32716029 DOI: 10.1093/Nar/Gkaa614 |
0.774 |
|
| 2020 |
Neal JA, Dunger K, Geith K, Meek K. Deciphering the role of distinct DNA-PK phosphorylations at collapsed replication forks. Dna Repair. 94: 102925. PMID 32674014 DOI: 10.1016/J.Dnarep.2020.102925 |
0.75 |
|
| 2020 |
Meek K. An Antiviral DNA Response without the STING? Trends in Immunology. PMID 32305305 DOI: 10.1016/J.It.2020.03.010 |
0.569 |
|
| 2019 |
Meek K. RAGs usurp cellular factors for both breaking and repairing. Blood. 133: 773-774. PMID 30792222 DOI: 10.1182/Blood-2019-01-892729 |
0.512 |
|
| 2018 |
Neal JA, Meek K. Deciphering phenotypic variance in different models of DNA-PKcs deficiency. Dna Repair. PMID 30409670 DOI: 10.1016/J.Dnarep.2018.10.004 |
0.752 |
|
| 2017 |
Müller TA, Struble SL, Meek K, Hausinger RP. Characterization of human AlkB homolog 1 produced in mammalian cells and demonstration of mitochondrial dysfunction in ALKBH1-deficient cells. Biochemical and Biophysical Research Communications. PMID 29097205 DOI: 10.1016/J.Bbrc.2017.10.158 |
0.611 |
|
| 2017 |
Normanno D, Négrel A, de Melo AJ, Betzi S, Meek K, Modesti M. Mutational phospho-mimicry reveals a regulatory role for the XRCC4 and XLF C-terminal tails in modulating DNA bridging during classical non-homologous end joining. Elife. 6. PMID 28500754 DOI: 10.7554/Elife.22900 |
0.762 |
|
| 2016 |
Tadi SK, Tellier-Lebègue C, Nemoz C, Drevet P, Audebert S, Roy S, Meek K, Charbonnier JB, Modesti M. PAXX Is an Accessory c-NHEJ Factor that Associates with Ku70 and Has Overlapping Functions with XLF. Cell Reports. 17: 541-555. PMID 27705800 DOI: 10.1016/J.Celrep.2016.09.026 |
0.59 |
|
| 2016 |
Meek K, Xu Y, Bailie C, Yu K, Neal JA. The ATM Kinase Restrains Joining of Both VDJ Signal and Coding Ends. Journal of Immunology (Baltimore, Md. : 1950). PMID 27574300 DOI: 10.4049/Jimmunol.1600597 |
0.484 |
|
| 2016 |
Neal JA, Xu Y, Abe M, Hendrickson E, Meek K. Restoration of ATM Expression in DNA-PKcs-Deficient Cells Inhibits Signal End Joining. Journal of Immunology (Baltimore, Md. : 1950). PMID 26921311 DOI: 10.4049/Jimmunol.1501654 |
0.651 |
|
| 2016 |
Masani S, Han L, Meek K, Yu K. Redundant function of DNA ligase 1 and 3 in alternative end-joining during immunoglobulin class switch recombination. Proceedings of the National Academy of Sciences of the United States of America. PMID 26787901 DOI: 10.1073/Pnas.1521630113 |
0.652 |
|
| 2015 |
Ying S, Chen Z, Medhurst AL, Neal JA, Bao Z, Mortusewicz O, McGouran J, Song X, Shen H, Hamdy FC, Kessler BM, Meek K, Helleday T. DNA-PKcs and PARP1 bind to unresected stalled DNA replication forks where they recruit XRCC1 to mediate repair. Cancer Research. PMID 26603896 DOI: 10.1158/0008-5472.Can-15-0608 |
0.742 |
|
| 2015 |
Roy S, de Melo AJ, Xu Y, Tadi SK, Négrel A, Hendrickson E, Modesti M, Meek K. XRCC4/XLF interaction is variably required for DNA repair, and is not required for Ligase IV stimulation. Molecular and Cellular Biology. PMID 26100018 DOI: 10.1128/Mcb.01503-14 |
0.621 |
|
| 2014 |
Petersen-Jones S, Meek K. DNA damage: offing KAP to stay focused in the dark. Current Biology : Cb. 24: R392-4. PMID 24845667 DOI: 10.1016/J.Cub.2014.03.076 |
0.569 |
|
| 2014 |
Douglas P, Ye R, Trinkle-Mulcahy L, Neal JA, De Wever V, Morrice NA, Meek K, Lees-Miller SP. Polo-like kinase 1 (PLK1) and protein phosphatase 6 (PP6) regulate DNA-dependent protein kinase catalytic subunit (DNA-PKcs) phosphorylation in mitosis. Bioscience Reports. 34. PMID 24844881 DOI: 10.1042/Bsr20140051 |
0.73 |
|
| 2014 |
Neal JA, Sugiman-Marangos S, VanderVere-Carozza P, Wagner M, Turchi J, Lees-Miller SP, Junop MS, Meek K. Unraveling the complexities of DNA-dependent protein kinase autophosphorylation. Molecular and Cellular Biology. 34: 2162-75. PMID 24687855 DOI: 10.1128/Mcb.01554-13 |
0.74 |
|
| 2013 |
Müller TA, Yu K, Hausinger RP, Meek K. ALKBH1 is dispensable for abasic site cleavage during base excision repair and class switch recombination. Plos One. 8: e67403. PMID 23825659 DOI: 10.1371/Journal.Pone.0067403 |
0.534 |
|
| 2013 |
Woodbine L, Neal JA, Sasi NK, Shimada M, Deem K, Coleman H, Dobyns WB, Ogi T, Meek K, Davies EG, Jeggo PA. PRKDC mutations in a SCID patient with profound neurological abnormalities. The Journal of Clinical Investigation. 123: 2969-80. PMID 23722905 DOI: 10.1172/Jci67349 |
0.712 |
|
| 2013 |
Mahaney BL, Hammel M, Meek K, Tainer JA, Lees-Miller SP. XRCC4 and XLF form long helical protein filaments suitable for DNA end protection and alignment to facilitate DNA double strand break repair. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 91: 31-41. PMID 23442139 DOI: 10.1139/Bcb-2012-0058 |
0.729 |
|
| 2012 |
Roy S, Andres SN, Vergnes A, Neal JA, Xu Y, Yu Y, Lees-Miller SP, Junop M, Modesti M, Meek K. XRCC4's interaction with XLF is required for coding (but not signal) end joining. Nucleic Acids Research. 40: 1684-94. PMID 22228831 DOI: 10.1093/Nar/Gkr1315 |
0.721 |
|
| 2012 |
Meek K, Lees-Miller SP, Modesti M. N-terminal constraint activates the catalytic subunit of the DNA-dependent protein kinase in the absence of DNA or Ku. Nucleic Acids Research. 40: 2964-73. PMID 22167471 DOI: 10.1093/Nar/Gkr1211 |
0.731 |
|
| 2011 |
Neal JA, Meek K. Choosing the right path: does DNA-PK help make the decision? Mutation Research. 711: 73-86. PMID 21376743 DOI: 10.1016/J.Mrfmmm.2011.02.010 |
0.726 |
|
| 2011 |
Shibata A, Conrad S, Birraux J, Geuting V, Barton O, Ismail A, Kakarougkas A, Meek K, Taucher-Scholz G, Löbrich M, Jeggo PA. Factors determining DNA double-strand break repair pathway choice in G2 phase. The Embo Journal. 30: 1079-92. PMID 21317870 DOI: 10.1038/Emboj.2011.27 |
0.682 |
|
| 2011 |
Neal JA, Dang V, Douglas P, Wold MS, Lees-Miller SP, Meek K. Inhibition of homologous recombination by DNA-dependent protein kinase requires kinase activity, is titratable, and is modulated by autophosphorylation. Molecular and Cellular Biology. 31: 1719-33. PMID 21300785 DOI: 10.1128/Mcb.01298-10 |
0.774 |
|
| 2010 |
Müller TA, Meek K, Hausinger RP. Human AlkB homologue 1 (ABH1) exhibits DNA lyase activity at abasic sites. Dna Repair. 9: 58-65. PMID 19959401 DOI: 10.1016/J.Dnarep.2009.10.011 |
0.672 |
|
| 2009 |
Meek K. New targets to translate DNA-PK signals. Cell Cycle (Georgetown, Tex.). 8: 3809. PMID 19887906 |
0.479 |
|
| 2009 |
Meek K, Jutkowitz A, Allen L, Glover J, Convery E, Massa A, Mullaney T, Stanley B, Rosenstein D, Bailey SM, Johnson C, Georges G. SCID dogs: similar transplant potential but distinct intra-uterine growth defects and premature replicative senescence compared with SCID mice. Journal of Immunology (Baltimore, Md. : 1950). 183: 2529-36. PMID 19635917 DOI: 10.4049/jimmunol.0801406 |
0.515 |
|
| 2009 |
Williams ES, Klingler R, Ponnaiya B, Hardt T, Schrock E, Lees-Miller SP, Meek K, Ullrich RL, Bailey SM. Telomere dysfunction and DNA-PKcs deficiency: characterization and consequence. Cancer Research. 69: 2100-7. PMID 19244120 DOI: 10.1158/0008-5472.Can-08-2854 |
0.747 |
|
| 2009 |
Mahaney BL, Meek K, Lees-Miller SP. Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining. The Biochemical Journal. 417: 639-50. PMID 19133841 DOI: 10.1042/Bj20080413 |
0.772 |
|
| 2008 |
Meek K, Dang V, Lees-Miller SP. DNA-PK: the means to justify the ends? Advances in Immunology. 99: 33-58. PMID 19117531 DOI: 10.1016/S0065-2776(08)00602-0 |
0.773 |
|
| 2007 |
Cui X, Meek K. Linking double-stranded DNA breaks to the recombination activating gene complex directs repair to the nonhomologous end-joining pathway. Proceedings of the National Academy of Sciences of the United States of America. 104: 17046-51. PMID 17939999 DOI: 10.1073/pnas.0610928104 |
0.695 |
|
| 2007 |
Corneo B, Wendland RL, Deriano L, Cui X, Klein IA, Wong SY, Arnal S, Holub AJ, Weller GR, Pancake BA, Shah S, Brandt VL, Meek K, Roth DB. Rag mutations reveal robust alternative end joining Nature. 449: 483-486. PMID 17898768 DOI: 10.1038/Nature06168 |
0.533 |
|
| 2007 |
Meek K, Douglas P, Cui X, Ding Q, Lees-Miller SP. trans Autophosphorylation at DNA-dependent protein kinase's two major autophosphorylation site clusters facilitates end processing but not end joining. Molecular and Cellular Biology. 27: 3881-90. PMID 17353268 DOI: 10.1128/Mcb.02366-06 |
0.726 |
|
| 2007 |
Douglas P, Cui X, Block WD, Yu Y, Gupta S, Ding Q, Ye R, Morrice N, Lees-Miller SP, Meek K. The DNA-dependent protein kinase catalytic subunit is phosphorylated in vivo on threonine 3950, a highly conserved amino acid in the protein kinase domain. Molecular and Cellular Biology. 27: 1581-91. PMID 17158925 DOI: 10.1128/Mcb.01962-06 |
0.718 |
|
| 2005 |
Gupta S, Meek K. The leucine rich region of DNA-PKcs contributes to its innate DNA affinity. Nucleic Acids Research. 33: 6972-81. PMID 16340007 DOI: 10.1093/nar/gki990 |
0.746 |
|
| 2005 |
Cui X, Yu Y, Gupta S, Cho YM, Lees-Miller SP, Meek K. Autophosphorylation of DNA-dependent protein kinase regulates DNA end processing and may also alter double-strand break repair pathway choice. Molecular and Cellular Biology. 25: 10842-52. PMID 16314509 DOI: 10.1128/Mcb.25.24.10842-10852.2005 |
0.761 |
|
| 2005 |
Douglas P, Gupta S, Morrice N, Meek K, Lees-Miller SP. DNA-PK-dependent phosphorylation of Ku70/80 is not required for non-homologous end joining. Dna Repair. 4: 1006-18. PMID 15941674 DOI: 10.1016/J.Dnarep.2005.05.003 |
0.721 |
|
| 2005 |
Convery E, Shin EK, Ding Q, Wang W, Douglas P, Davis LS, Nickoloff JA, Lees-Miller SP, Meek K. Inhibition of homologous recombination by variants of the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs). Proceedings of the National Academy of Sciences of the United States of America. 102: 1345-50. PMID 15668400 DOI: 10.1073/Pnas.0406466102 |
0.759 |
|
| 2004 |
Block WD, Yu Y, Merkle D, Gifford JL, Ding Q, Meek K, Lees-Miller SP. Autophosphorylation-dependent remodeling of the DNA-dependent protein kinase catalytic subunit regulates ligation of DNA ends. Nucleic Acids Research. 32: 4351-7. PMID 15314205 DOI: 10.1093/Nar/Gkh761 |
0.788 |
|
| 2004 |
Reddy YV, Ding Q, Lees-Miller SP, Meek K, Ramsden DA. Non-homologous end joining requires that the DNA-PK complex undergo an autophosphorylation-dependent rearrangement at DNA ends. The Journal of Biological Chemistry. 279: 39408-13. PMID 15258142 DOI: 10.1074/Jbc.M406432200 |
0.746 |
|
| 2004 |
Meek K, Gupta S, Ramsden DA, Lees-Miller SP. The DNA-dependent protein kinase: the director at the end. Immunological Reviews. 200: 132-41. PMID 15242401 DOI: 10.1111/J.0105-2896.2004.00162.X |
0.778 |
|
| 2004 |
Block WD, Merkle D, Meek K, Lees-Miller SP. Selective inhibition of the DNA-dependent protein kinase (DNA-PK) by the radiosensitizing agent caffeine. Nucleic Acids Research. 32: 1967-72. PMID 15060176 DOI: 10.1093/Nar/Gkh508 |
0.719 |
|
| 2004 |
Wechsler T, Chen BP, Harper R, Morotomi-Yano K, Huang BC, Meek K, Cleaver JE, Chen DJ, Wabl M. DNA-PKcs function regulated specifically by protein phosphatase 5. Proceedings of the National Academy of Sciences of the United States of America. 101: 1247-52. PMID 14734805 DOI: 10.1073/Pnas.0307765100 |
0.718 |
|
| 2003 |
Lees-Miller SP, Meek K. Repair of DNA double strand breaks by non-homologous end joining. Biochimie. 85: 1161-73. PMID 14726021 DOI: 10.1016/J.Biochi.2003.10.011 |
0.758 |
|
| 2003 |
Yu Y, Wang W, Ding Q, Ye R, Chen D, Merkle D, Schriemer D, Meek K, Lees-Miller SP. DNA-PK phosphorylation sites in XRCC4 are not required for survival after radiation or for V(D)J recombination. Dna Repair. 2: 1239-52. PMID 14599745 DOI: 10.1016/S1568-7864(03)00143-5 |
0.761 |
|
| 2003 |
Kilzer JM, Stracker T, Beitzel B, Meek K, Weitzman M, Bushman FD. Roles of host cell factors in circularization of retroviral dna. Virology. 314: 460-7. PMID 14517098 DOI: 10.1016/S0042-6822(03)00455-0 |
0.721 |
|
| 2003 |
Ding Q, Reddy YV, Wang W, Woods T, Douglas P, Ramsden DA, Lees-Miller SP, Meek K. Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair. Molecular and Cellular Biology. 23: 5836-48. PMID 12897153 DOI: 10.1128/Mcb.23.16.5836-5848.2003 |
0.784 |
|
| 2002 |
Woods T, Wang W, Convery E, Errami A, Zdzienicka MZ, Meek K. A single amino acid substitution in DNA-PKcs explains the novel phenotype of the CHO mutant, XR-C2. Nucleic Acids Research. 30: 5120-8. PMID 12466535 DOI: 10.1093/NAR/GKF625 |
0.57 |
|
| 2002 |
Douglas P, Sapkota GP, Morrice N, Yu Y, Goodarzi AA, Merkle D, Meek K, Alessi DR, Lees-Miller SP. Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase. The Biochemical Journal. 368: 243-51. PMID 12186630 DOI: 10.1042/Bj20020973 |
0.771 |
|
| 2002 |
Ding Q, Bramble L, Yuzbasiyan-Gurkan V, Bell T, Meek K. DNA-PKcs mutations in dogs and horses: allele frequency and association with neoplasia. Gene. 283: 263-9. PMID 11867233 DOI: 10.1016/S0378-1119(01)00880-0 |
0.583 |
|
| 2001 |
Meek K, Kienker L, Dallas C, Wang W, Dark MJ, Venta PJ, Huie ML, Hirschhorn R, Bell T. SCID in Jack Russell terriers: A new animal model of DNA-PKcs deficiency Journal of Immunology. 167: 2142-2150. PMID 11489998 DOI: 10.4049/Jimmunol.167.4.2142 |
0.708 |
|
| 2000 |
Kienker LJ, Shin EK, Meek K. Both V(D)J recombination and radioresistance require DNA-PK kinase activity, though minimal levels suffice for V(D)J recombination. Nucleic Acids Research. 28: 2752-61. PMID 10908332 DOI: 10.1093/NAR/28.14.2752 |
0.664 |
|
| 2000 |
Shin EK, Rijkers T, Pastink A, Meek K. Analyses of TCRB rearrangements substantiate a profound deficit in recombination signal sequence joining in SCID foals: implications for the role of DNA-dependent protein kinase in V(D)J recombination. Journal of Immunology (Baltimore, Md. : 1950). 164: 1416-24. PMID 10640757 DOI: 10.4049/jimmunol.164.3.1416 |
0.583 |
|
| 1999 |
Leber R, Wiler R, Perryman LE, Meek K. Equine SCID: mechanistic analysis and comparison with murine SCID. Veterinary Immunology and Immunopathology. 65: 1-9. PMID 9802572 DOI: 10.1016/S0165-2427(98)00174-3 |
0.404 |
|
| 1998 |
Liu L, Kwak YT, Bex F, García-Martínez LF, Li XH, Meek K, Lane WS, Gaynor RB. DNA-dependent protein kinase phosphorylation of IkappaB alpha and IkappaB beta regulates NF-kappaB DNA binding properties. Molecular and Cellular Biology. 18: 4221-34. PMID 9632806 DOI: 10.1128/MCB.18.7.4221 |
0.523 |
|
| 1998 |
Leber R, Wise TW, Mizuta R, Meek K. The XRCC4 Gene Product Is a Target for and Interacts with the DNA-dependent Protein Kinase Journal of Biological Chemistry. 273: 1794-1801. PMID 9430729 DOI: 10.1074/Jbc.273.3.1794 |
0.751 |
|
| 1996 |
Wiler R, Leber R, Moore BB, VanDyk LF, Perryman LE, Meek K. Equine SCID: a defect in V(D)J recombination, double strand break repair and DNA-dependent protein kinase activity Veterinary Immunology and Immunopathology. 54: 19. DOI: 10.1016/S0165-2427(96)05643-7 |
0.633 |
|
| 1995 |
Wiler R, Leber R, Moore BB, Vandyk LF, Perryman LE, Meek K. Equine severe combined immunodeficiency: A defect in V(D)J recombination and DNA-dependent protein kinase activity Proceedings of the National Academy of Sciences of the United States of America. 92: 11485-11489. PMID 8524788 DOI: 10.1073/Pnas.92.25.11485 |
0.509 |
|
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