Nejat Egilmez - Publications

Affiliations: 
Microbiology and Immunology State University of New York, Buffalo, Buffalo, NY, United States 
Area:
Immunology

66 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Li Q, Goggin KE, Seo S, Warawa JM, Egilmez NK. Correction to: Anti‑PD‑1 antibody‑activated Th17 cells subvert re‑invigoration of antitumor cytotoxic T‑lymphocytes via myeloid cell‑derived COX‑2/PGE. Cancer Immunology, Immunotherapy : Cii. PMID 36806903 DOI: 10.1007/s00262-023-03403-9  0.349
2022 Li Q, Goggin KE, Seo S, Warawa JM, Egilmez NK. Anti-PD-1 antibody-activated Th17 cells subvert re-invigoration of antitumor cytotoxic T-lymphocytes via myeloid cell-derived COX-2/PGE. Cancer Immunology, Immunotherapy : Cii. PMID 36074159 DOI: 10.1007/s00262-022-03285-3  0.546
2021 Jin R, Hao J, Yi Y, Yin D, Hua Y, Li X, Bao H, Han X, Egilmez NK, Sauter ER, Li B. Dietary fats high in linoleic acids impair anti-tumor T cell responses by inducing E-FABP-mediated mitochondrial dysfunction. Cancer Research. PMID 34400394 DOI: 10.1158/0008-5472.CAN-21-0757  0.388
2020 Li Q, Ngo PT, Egilmez NK. Anti-PD-1 antibody-mediated activation of type 17 T-cells undermines checkpoint blockade therapy. Cancer Immunology, Immunotherapy : Cii. PMID 33245376 DOI: 10.1007/s00262-020-02795-2  0.559
2020 Han BJ, Murphy JD, Qin S, Ye J, Uccello TP, Garrett-Larsen J, Belt BA, Prieto PA, Egilmez NK, Lord EM, Linehan DC, Mills BN, Gerber SA. Microspheres Encapsulating Immunotherapy Agents Target the Tumor-Draining Lymph Node in Pancreatic Ductal Adenocarcinoma. Immunological Investigations. 1-16. PMID 32498585 DOI: 10.1080/08820139.2020.1765795  0.313
2019 Gu T, Li Q, Egilmez NK. IFNβ-producing CX3CR1 macrophages promote T-regulatory cell expansion and tumor growth in the APC / colon cancer model. Oncoimmunology. 8: e1665975. PMID 31741765 DOI: 10.1080/2162402X.2019.1665975  0.638
2019 Mills BN, Connolly KA, Ye J, Murphy JD, Uccello TP, Han BJ, Zhao T, Drage MG, Murthy A, Qiu H, Patel A, Figueroa NM, Johnston CJ, Prieto PA, Egilmez NK, et al. Stereotactic Body Radiation and Interleukin-12 Combination Therapy Eradicates Pancreatic Tumors by Repolarizing the Immune Microenvironment. Cell Reports. 29: 406-421.e5. PMID 31597100 DOI: 10.1016/J.Celrep.2019.08.095  0.474
2019 Barsoumian HB, Batra L, Shrestha P, Bowen WS, Zhao H, Egilmez NK, Gomez-Gutierrez JG, Yolcu ES, Shirwan H. A Novel Form of 4-1BBL Prevents Cancer Development via Nonspecific Activation of CD4 T and Natural Killer Cells. Cancer Research. 79: 783-794. PMID 30770367 DOI: 10.1158/0008-5472.Can-18-2401  0.537
2018 Bhutiani N, Li Q, Anderson CD, Gallagher HC, De Jesus M, Singh R, Jala VR, Fraig M, Gu T, Egilmez NK. Enhanced gut barrier integrity sensitizes colon cancer to immune therapy. Oncoimmunology. 7: e1498438. PMID 30377564 DOI: 10.1080/2162402X.2018.1498438  0.455
2018 Li Q, Anderson CD, Egilmez NK. Inhaled IL-10 Suppresses Lung Tumorigenesis via Abrogation of Inflammatory Macrophage-Th17 Cell Axis. Journal of Immunology (Baltimore, Md. : 1950). PMID 30257887 DOI: 10.4049/jimmunol.1800141  0.503
2018 Hao J, Yan F, Zhang Y, Triplett A, Zhang Y, Schultz DA, Sun Y, Zeng J, Silverstein KAT, Zheng Q, Bernlohr DA, Cleary MP, Egilmez NK, Sauter E, Liu S, et al. Expression of adipocyte/macrophage fatty acid binding protein in tumor associated macrophages promotes breast cancer progression. Cancer Research. PMID 29437708 DOI: 10.1158/0008-5472.Can-17-2465  0.321
2018 Liu Y, Perez J, Hammer LA, Gallagher HC, De Jesus M, Egilmez NK, Russell MW. Intravaginal Administration of Interleukin 12 during Genital Gonococcal Infection in Mice Induces Immunity to Heterologous Strains of Neisseria gonorrhoeae. Msphere. 3. PMID 29404418 DOI: 10.1128/mSphere.00421-17  0.352
2017 Gu T, De Jesus M, Gallagher HC, Burris TP, Egilmez NK. Oral IL-10 suppresses colon carcinogenesis via elimination of pathogenicCD4(+) T-cells and induction of antitumor CD8(+) T-cell activity. Oncoimmunology. 6: e1319027. PMID 28680752 DOI: 10.1080/2162402X.2017.1319027  0.659
2017 Liu Y, Hammer LA, Liu W, Hobbs MM, Zielke RA, Sikora AE, Jerse AE, Egilmez NK, Russell MW. Experimental vaccine induces Th1-driven immune responses and resistance to Neisseria gonorrhoeae infection in a murine model. Mucosal Immunology. PMID 28272393 DOI: 10.1038/Mi.2017.11  0.371
2016 Li Q, Egilmez NK. Ontogeny of Tumor-associated CD4+CD25+Foxp3+ T-regulatory Cells. Immunological Investigations. 1-17. PMID 27759490 DOI: 10.1080/08820139.2016.1220390  0.561
2016 Li Q, Harden JL, Anderson CD, Egilmez NK. Tolerogenic Phenotype of IFN-γ-Induced IDO+ Dendritic Cells Is Maintained via an Autocrine IDO-Kynurenine/AhR-IDO Loop. Journal of Immunology (Baltimore, Md. : 1950). PMID 27316681 DOI: 10.4049/Jimmunol.1502615  0.687
2016 Rao E, Zhang Y, Li Q, Hao J, Egilmez NK, Suttles J, Li B. AMPK-dependent and independent effects of AICAR and compound C on T-cell responses. Oncotarget. PMID 27177226 DOI: 10.18632/oncotarget.9277  0.421
2015 Ozbilge H, LeVea C, Chung AY, Li Q, Egilmez NK. Modulating gut immunity and neoplasia with oral cytokine adjuvants. Oncoimmunology. 4: e1002724. PMID 26137401 DOI: 10.1080/2162402X.2014.1002724  0.468
2015 Li Q, Virtuoso LP, Anderson CD, Egilmez NK. Regulatory Rebound in IL-12-Treated Tumors Is Driven by Uncommitted Peripheral Regulatory T Cells. Journal of Immunology (Baltimore, Md. : 1950). 195: 1293-300. PMID 26085681 DOI: 10.4049/jimmunol.1403078  0.636
2015 Dennis KL, Saadalla A, Blatner NR, Wang S, Venkateswaran V, Gounari F, Cheroutre H, Weaver CT, Roers A, Egilmez NK, Khazaie K. T-cell Expression of IL10 Is Essential for Tumor Immune Surveillance in the Small Intestine. Cancer Immunology Research. 3: 806-14. PMID 25855122 DOI: 10.1158/2326-6066.Cir-14-0169  0.561
2015 Rao E, Zhang Y, Zhu G, Hao J, Persson XM, Egilmez NK, Suttles J, Li B. Deficiency of AMPK in CD8+ T cells suppresses their anti-tumor function by inducing protein phosphatase-mediated cell death. Oncotarget. 6: 7944-58. PMID 25760243  0.622
2014 Chung AY, Li Q, Blair SJ, De Jesus M, Dennis KL, LeVea C, Yao J, Sun Y, Conway TF, Virtuoso LP, Battaglia NG, Furtado S, Mathiowitz E, Mantis NJ, Khazaie K, ... Egilmez NK, et al. Oral interleukin-10 alleviates polyposis via neutralization of pathogenic T-regulatory cells. Cancer Research. 74: 5377-85. PMID 25228656 DOI: 10.1158/0008-5472.Can-14-0918  0.497
2014 Gerber SA, Lim JY, Connolly KA, Sedlacek AL, Barlow ML, Murphy SP, Egilmez NK, Lord EM. Radio-responsive tumors exhibit greater intratumoral immune activity than nonresponsive tumors. International Journal of Cancer. Journal International Du Cancer. 134: 2383-92. PMID 24154990 DOI: 10.1002/Ijc.28558  0.544
2013 Liu Y, Egilmez NK, Russell MW. Enhancement of adaptive immunity to Neisseria gonorrhoeae by local intravaginal administration of microencapsulated interleukin 12. The Journal of Infectious Diseases. 208: 1821-9. PMID 24048962 DOI: 10.1093/Infdis/Jit354  0.362
2012 Manjili MH, Egilmez N, Knutson KL, Selvan SR, Ostberg JR. Tumor escape and progression under immune pressure. Clinical & Developmental Immunology. 2012: 641079. PMID 23316254 DOI: 10.1155/2012/641079  0.579
2012 Harden JL, Egilmez NK. Indoleamine 2,3-dioxygenase and dendritic cell tolerogenicity. Immunological Investigations. 41: 738-64. PMID 23017144 DOI: 10.3109/08820139.2012.676122  0.639
2012 Virtuoso LP, Harden JL, Sotomayor P, Sigurdson WJ, Yoshimura F, Egilmez NK, Minev B, Kilinc MO. Characterization of iNOS(+) Neutrophil-like ring cell in tumor-bearing mice. Journal of Translational Medicine. 10: 152. PMID 22846631 DOI: 10.1186/1479-5876-10-152  0.676
2012 Egilmez NK, Harden JL, Rowswell-Turner RB. Chemoimmunotherapy as long-term maintenance therapy for cancer. Oncoimmunology. 1: 563-565. PMID 22754788 DOI: 10.4161/Onci.19369  0.763
2011 Rowswell-Turner RB, Harden JL, Nair RE, Gu T, Kilinc MO, Egilmez NK. Chronic chemoimmunotherapy achieves cure of spontaneous murine mammary tumors via persistent blockade of posttherapy counter-regulation. Journal of Immunology (Baltimore, Md. : 1950). 187: 4109-18. PMID 21908736 DOI: 10.4049/Jimmunol.1101136  0.779
2011 Harden JL, Gu T, Kilinc MO, Rowswell-Turner RB, Virtuoso LP, Egilmez NK. Dichotomous effects of IFN-γ on dendritic cell function determine the extent of IL-12-driven antitumor T cell immunity. Journal of Immunology (Baltimore, Md. : 1950). 187: 126-32. PMID 21632715 DOI: 10.4049/Jimmunol.1100168  0.775
2011 Egilmez NK, Harden JL, Virtuoso LP, Schwendener RA, Kilinc MO. Nitric oxide short-circuits interleukin-12-mediated tumor regression. Cancer Immunology, Immunotherapy : Cii. 60: 839-45. PMID 21387108 DOI: 10.1007/S00262-011-0998-2  0.76
2010 Egilmez NK, Kilinc MO. Tumor-resident CD8+ T-cell: the critical catalyst in IL-12-mediated reversal of tumor immune suppression. Archivum Immunologiae Et Therapiae Experimentalis. 58: 399-405. PMID 20872283 DOI: 10.1007/s00005-010-0097-7  0.623
2010 Gu T, Rowswell-Turner RB, Kilinc MO, Egilmez NK. Central role of IFNgamma-indoleamine 2,3-dioxygenase axis in regulation of interleukin-12-mediated antitumor immunity. Cancer Research. 70: 129-38. PMID 20028855 DOI: 10.1158/0008-5472.CAN-09-3170  0.811
2009 Kilinc MO, Rowswell-Turner RB, Gu T, Virtuoso LP, Egilmez NK. Activated CD8+ T-effector/memory cells eliminate CD4+ CD25+ Foxp3+ T-suppressor cells from tumors via FasL mediated apoptosis. Journal of Immunology (Baltimore, Md. : 1950). 183: 7656-60. PMID 19923444 DOI: 10.4049/jimmunol.0902625  0.797
2009 Watkins SK, Li B, Richardson KS, Head K, Egilmez NK, Zeng Q, Suttles J, Stout RD. Rapid release of cytoplasmic IL-15 from tumor-associated macrophages is an initial and critical event in IL-12-initiated tumor regression. European Journal of Immunology. 39: 2126-35. PMID 19609975 DOI: 10.1002/Eji.200839010  0.436
2009 Kilinc MO, Gu T, Harden JL, Virtuoso LP, Egilmez NK. Central role of tumor-associated CD8+ T effector/memory cells in restoring systemic antitumor immunity. Journal of Immunology (Baltimore, Md. : 1950). 182: 4217-25. PMID 19299720 DOI: 10.4049/Jimmunol.0802793  0.79
2008 Gu T, Kilinc MO, Egilmez NK. Transient activation of tumor-associated T-effector/memory cells promotes tumor eradication via NK-cell recruitment: minimal role for long-term T-cell immunity in cure of metastatic disease. Cancer Immunology, Immunotherapy : Cii. 57: 997-1005. PMID 18049819 DOI: 10.1007/s00262-007-0430-0  0.673
2007 Egilmez NK, Kilinc MO, Gu T, Conway TF. Controlled-release particulate cytokine adjuvants for cancer therapy. Endocrine, Metabolic & Immune Disorders Drug Targets. 7: 266-70. PMID 18220947 DOI: 10.2174/187153007782794335  0.635
2007 Watkins SK, Egilmez NK, Suttles J, Stout RD. IL-12 rapidly alters the functional profile of tumor-associated and tumor-infiltrating macrophages in vitro and in vivo. Journal of Immunology (Baltimore, Md. : 1950). 178: 1357-62. PMID 17237382 DOI: 10.4049/Jimmunol.178.3.1357  0.479
2006 Kilinc MO, Aulakh KS, Nair RE, Jones SA, Alard P, Kosiewicz MM, Egilmez NK. Reversing tumor immune suppression with intratumoral IL-12: activation of tumor-associated T effector/memory cells, induction of T suppressor apoptosis, and infiltration of CD8+ T effectors. Journal of Immunology (Baltimore, Md. : 1950). 177: 6962-73. PMID 17082611  0.7
2006 Nair RE, Kilinc MO, Jones SA, Egilmez NK. Chronic immune therapy induces a progressive increase in intratumoral T suppressor activity and a concurrent loss of tumor-specific CD8+ T effectors in her-2/neu transgenic mice bearing advanced spontaneous tumors. Journal of Immunology (Baltimore, Md. : 1950). 176: 7325-34. PMID 16751376  0.708
2006 Nair RE, Jong YS, Jones SA, Sharma A, Mathiowitz E, Egilmez NK. IL-12 + GM-CSF microsphere therapy induces eradication of advanced spontaneous tumors in her-2/neu transgenic mice but fails to achieve long-term cure due to the inability to maintain effector T-cell activity. Journal of Immunotherapy (Hagerstown, Md. : 1997). 29: 10-20. PMID 16365596 DOI: 10.1097/01.Cji.0000175489.19314.D2  0.61
2006 Lou Q, Conway TF, Egilmez NK, Loyall JL, Bernstein SH, Kelleher RJ, Bankert RB. B cell tumor vaccine enhanced by covalent attachment of immunoglobulin to surface proteins on dendritic cells. Clinical Immunology (Orlando, Fla.). 118: 66-76. PMID 16185929 DOI: 10.1016/J.Clim.2005.08.014  0.366
2005 Sabel MS, Hess SD, Egilmez NK, Conway TF, Chen FA, Bankert RB. CTLA-4 blockade augments human T lymphocyte-mediated suppression of lung tumor xenografts in SCID mice. Cancer Immunology, Immunotherapy : Cii. 54: 944-52. PMID 15846492 DOI: 10.1007/S00262-005-0668-3  0.465
2005 Kilinc OM, Aulakh KS, Nair RE, Jones SA, Alard P, Kosiewicz MM, Egilmez NK. Intra-Tumoral IL-12 + GM-CSF Microsphere Therapy Induces Activation of Tumor-Associated T-Effector/Memory Cells, Exodus of CD4+ CD25+ T-Suppressors and Infiltration of CD8+ T-Effectors Journal of Immunotherapy. 28: 649. DOI: 10.1097/01.cji.0000191069.26877.2c  0.637
2004 Sharma A, Harper CM, Hammer L, Nair RE, Mathiowitz E, Egilmez NK. Characterization of cytokine-encapsulated controlled-release microsphere adjuvants. Cancer Biotherapy & Radiopharmaceuticals. 19: 764-9. PMID 15665625 DOI: 10.1089/Cbr.2004.19.764  0.324
2004 Sabel MS, Skitzki J, Stoolman L, Egilmez NK, Mathiowitz E, Bailey N, Chang WJ, Chang AE. Intratumoral IL-12 and TNF-alpha-loaded microspheres lead to regression of breast cancer and systemic antitumor immunity. Annals of Surgical Oncology. 11: 147-56. PMID 14761917 DOI: 10.1245/Aso.2004.03.022  0.31
2004 Nair ER, Jong YS, Egilmez NK. Regression of Established Autochthonous Mammary Tumors and Induction of Systemic Anti-Tumor T- and B-Cell Immunity in HER-2/NEU Transgenic Mice after Treatment with IL-12 and GM-CSF-Encapsulated Microspheres Journal of Immunotherapy. 27: S37. DOI: 10.1097/00002371-200411000-00135  0.56
2004 Sabel MS, Chang WJ, Egilmez NK, Mathiowitz E, Chang AE. Intralesional IL-12 and TNF-α loaded microspheres can generate systemic anti-tumor immunity to B16 melanoma Annals of Surgical Oncology. 11: S87-S87. DOI: 10.1007/Bf02524080  0.339
2003 Eğilmez NK, Bankert RB. Liposome-mediated cytokine gene delivery to human tumor xenografts. Methods in Enzymology. 373: 529-35. PMID 14714425 DOI: 10.1016/S0076-6879(03)73033-X  0.324
2003 Anderson TM, Hess SD, Egilmez NK, Nwogu CE, Lenox JM, Bankert RB. Comparison of human lung cancer/SCID mouse tumor xenografts and cell culture growth with patient clinical outcomes. Journal of Cancer Research and Clinical Oncology. 129: 565-8. PMID 12923636 DOI: 10.1007/S00432-003-0473-3  0.324
2003 Hess SD, Egilmez NK, Bailey N, Anderson TM, Mathiowitz E, Bernstein SH, Bankert RB. Human CD4+ T cells present within the microenvironment of human lung tumors are mobilized by the local and sustained release of IL-12 to kill tumors in situ by indirect effects of IFN-gamma. Journal of Immunology (Baltimore, Md. : 1950). 170: 400-12. PMID 12496425 DOI: 10.4049/Jimmunol.170.1.400  0.552
2002 Hill HC, Conway TF, Sabel MS, Jong YS, Mathiowitz E, Bankert RB, Egilmez NK. Cancer immunotherapy with interleukin 12 and granulocyte-macrophage colony-stimulating factor-encapsulated microspheres: coinduction of innate and adaptive antitumor immunity and cure of disseminated disease. Cancer Research. 62: 7254-63. PMID 12499267  0.538
2002 Egilmez NK, Hess SD, Chen FA, Takita H, Conway TF, Bankert RB. Human CD4+ effector T cells mediate indirect interleukin-12- and interferon-gamma-dependent suppression of autologous HLA-negative lung tumor xenografts in severe combined immunodeficient mice. Cancer Research. 62: 2611-7. PMID 11980657  0.607
2001 Sabel MS, Hill H, Jong YS, Mathiowitz E, Bankert RB, Egilmez NK. Neoadjuvant therapy with interleukin-12-loaded polylactic acid microspheres reduces local recurrence and distant metastases Surgery. 130: 470-478. PMID 11562672 DOI: 10.1067/Msy.2001.115839  0.349
2001 Hess SD, Egilmez NK, Shiroko J, Bankert RB. Antitumor efficacy of a human interleukin-12 expression plasmid demonstrated in a human peripheral blood leukocyte/human lung tumor xenograft SCID mouse model Cancer Gene Therapy. 8: 371-377. PMID 11477457 DOI: 10.1038/Sj.Cgt.7700314  0.466
2001 Yamada M, Shiroko T, Kawaguchi Y, Sugiyama Y, Egilmez NK, Chen FA, Bankert RB. CD40-CD40 ligand (CD154) engagement is required but not sufficient for modulating MHC class I, ICAM-1 and fas expression and proliferation of human non-small cell lung tumors International Journal of Cancer. 92: 589-599. PMID 11304696 DOI: 10.1002/Ijc.1224  0.419
2001 Sugiyama Y, Kato M, Chen FA, Williams SS, Kawaguchi Y, Miya K, Jong YS, Mathiowitz E, Egilmez NK, Bankert RB. Human inflammatory cells within the tumor microenvironment of lung tumor xenografts mediate tumor growth suppression in situ that depends on and is augmented by interleukin-12 Journal of Immunotherapy. 24: 37-45. PMID 11211147 DOI: 10.1097/00002371-200101000-00005  0.43
2001 Hill H, Sabel M, Banket R, Egilmez N. Interleukin-12 (IL-12) + Granulocyte/Macrophage-Colony Stimulating Factor (GM-CSF) loaded microspheres protects against metastasis by enhancing natural killer cell function in Balb/c and scid-Line-1 metastasis model Current Surgery. 58: 504. DOI: 10.1016/S0149-7944(01)00525-6  0.317
2000 Bankert RB, Chen FA, Sugiyama Y, Egilmez N. Patient immune response to tumors monitored using scid mouse models Immunological Investigations. 29: 171-176. PMID 10854186  0.311
2000 Egilmez NK, Jong YS, Hess SD, Jacob JS, Mathiowitz E, Bankert RB. Cytokines delivered by biodegradable microspheres promote effective suppression of human tumors by human peripheral blood lymphocytes in the SCID-Winn model Journal of Immunotherapy. 23: 190-195. PMID 10746545 DOI: 10.1097/00002371-200003000-00003  0.378
2000 Conway TF, Sabel MS, Sugano M, Frelinger JG, Egilmez NK, Chen FA, Bankert RB. Growth of human tumor xenografts in SCID mice quantified using an immunoassay for tumor marker protein in serum Journal of Immunological Methods. 233: 57-65. PMID 10648856 DOI: 10.1016/S0022-1759(99)00190-8  0.33
2000 Kuriakose MA, Chen FA, Egilmez NK, Jong YS, Mathiowitz E, DeLacure MD, Hicks WL, Loree TL, Bankert RB. Interleukin-12 delivered by biodegradable microspheres promotes the antitumor activity of human peripheral blood lymphocytes in a human head and neck tumor xenograft/SCID mouse model Head and Neck. 22: 57-63. PMID 10585606 DOI: 10.1002/(Sici)1097-0347(200001)22:1<57::Aid-Hed9>3.0.Co;2-K  0.526
2000 Hill HC, Sabel M, Egilmez N, Bankert RB. An in-situ neoadjuvant vaccination with IL-12 and GM-CSF in biodegradable microspheres with systemic IL-2 provides protection against metastatic disease. Journal of the American College of Surgeons. 191: S19-S20. DOI: 10.1016/S1072-7515(00)00427-0  0.371
1999 Jong YS, Egilmez NK, Chen FA, Jacob JS, Smith LP, Mottl TS, Bankert RB, Mathiowitz E. Evaluation of cytokine delivery systems for cancer immunotherapy Materials Research Society Symposium - Proceedings. 550: 71-75. DOI: 10.1557/Proc-550-71  0.334
1998 Egilmez NK, Jong YS, Iwanuma Y, Jacob JS, Santos CA, Chen FA, Mathiowitz E, Bankert RB. Cytokine immunotherapy of cancer with controlled release biodegradable microspheres in a human tumor xenograft/SCID mouse model Cancer Immunology Immunotherapy. 46: 21-24. PMID 9520288 DOI: 10.1007/S002620050455  0.442
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