Manju M. Hingorani - Publications

Affiliations: 
Wesleyan University, Middletown, CT, United States 
Area:
General Biophysics, Biochemistry

38 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Li Y, Lombardo Z, Joshi M, Hingorani MM, Mukerji I. Mismatch Recognition by Msh2-Msh6: Role of Structure and Dynamics. International Journal of Molecular Sciences. 20. PMID 31480444 DOI: 10.3390/ijms20174271  0.32
2019 Case BC, Hartley S, Osuga M, Jeruzalmi D, Hingorani MM. The ATPase mechanism of UvrA2 reveals the distinct roles of proximal and distal ATPase sites in nucleotide excision repair. Nucleic Acids Research. PMID 30892613 DOI: 10.1093/nar/gkz180  0.4
2019 Qiu R, DeRocco VC, Harris C, Sharma A, Hingorani MM, Erie DA, Weninger KR. Large conformational changes in MutS during DNA scanning, mismatch recognition and repair signaling. The Embo Journal. 38. PMID 30770383 DOI: 10.15252/embj.2019101518  0.72
2018 Lahiri S, Li Y, Hingorani MM, Mukerji I. MutSγ-Induced DNA Conformational Changes Provide Insights into its Role in Meiotic Recombination. Biophysical Journal. PMID 30467025 DOI: 10.1016/j.bpj.2018.10.029  0.32
2018 LeBlanc SJ, Gauer JW, Hao P, Case BC, Hingorani MM, Weninger KR, Erie DA. Coordinated protein and DNA conformational changes govern mismatch repair initiation by MutS. Nucleic Acids Research. PMID 30272207 DOI: 10.1093/nar/gky865  0.68
2018 Song B, Hamdan SM, Hingorani MM. Positioning the 5'-flap junction in the active site controls the rate of flap endonuclease-1-catalyzed DNA cleavage. The Journal of Biological Chemistry. PMID 29462789 DOI: 10.1074/jbc.RA117.001137  0.76
2018 Zaher MS, Rashid F, Song B, Joudeh LI, Sobhy MA, Tehseen M, Hingorani MM, Hamdan SM. Missed cleavage opportunities by FEN1 lead to Okazaki fragment maturation via the long-flap pathway. Nucleic Acids Research. PMID 29420814 DOI: 10.1093/nar/gky082  0.76
2017 Liu J, Zhou Y, Hingorani MM. Linchpin DNA-binding residues serve as go/no-go controls in the replication factor C-catalyzed clamp loading mechanism. The Journal of Biological Chemistry. PMID 28808059 DOI: 10.1074/jbc.M117.798702  1
2015 Qiu R, Sakato M, Sacho EJ, Wilkins H, Zhang X, Modrich P, Hingorani MM, Erie DA, Weninger KR. MutL traps MutS at a DNA mismatch. Proceedings of the National Academy of Sciences of the United States of America. 112: 10914-9. PMID 26283381 DOI: 10.1073/pnas.1505655112  1
2015 Liu J, Hingorani MM. 11 Checkpoints controlled by PCNA, DNA and ATP direct the timing and order of events in the clamp loading mechanism. Journal of Biomolecular Structure & Dynamics. 33: 7. PMID 26103222 DOI: 10.1080/07391102.2015.1032551  0.8
2013 Sharma A, Doucette C, Biro FN, Hingorani MM. Slow conformational changes in MutS and DNA direct ordered transitions between mismatch search, recognition and signaling of DNA repair. Journal of Molecular Biology. 425: 4192-205. PMID 23973435 DOI: 10.1016/j.jmb.2013.08.011  1
2013 Dieckman LM, Boehm EM, Hingorani MM, Washington MT. Distinct structural alterations in proliferating cell nuclear antigen block DNA mismatch repair. Biochemistry. 52: 5611-9. PMID 23869605 DOI: 10.1021/bi400378e  1
2013 Czyzyk DJ, Sawant SS, Ramirez-Mondragon CA, Hingorani MM, Taylor EA. Escherichia coli heptosyltransferase I: investigation of protein dynamics of a GT-B structural enzyme. Biochemistry. 52: 5158-60. PMID 23865375 DOI: 10.1021/bi400807r  1
2013 Lenhart JS, Sharma A, Hingorani MM, Simmons LA. DnaN clamp zones provide a platform for spatiotemporal coupling of mismatch detection to DNA replication. Molecular Microbiology. 87: 553-68. PMID 23228104 DOI: 10.1111/mmi.12115  1
2012 Zhou Y, Hingorani MM. Impact of individual proliferating cell nuclear antigen-DNA contacts on clamp loading and function on DNA. The Journal of Biological Chemistry. 287: 35370-81. PMID 22902629 DOI: 10.1074/jbc.M112.399071  1
2012 Qiu R, DeRocco VC, Harris C, Sharma A, Hingorani MM, Erie DA, Weninger KR. Large conformational changes in MutS during DNA scanning, mismatch recognition and repair signalling. The Embo Journal. 31: 2528-40. PMID 22505031 DOI: 10.1038/emboj.2012.95  1
2012 Das S, Grady LM, Michtavy J, Zhou Y, Cohan FM, Hingorani MM, Oliver DB. The variable subdomain of Escherichia coli SecA functions to regulate SecA ATPase activity and ADP release. Journal of Bacteriology. 194: 2205-13. PMID 22389482 DOI: 10.1128/JB.00039-12  1
2012 Sakato M, Zhou Y, Hingorani MM. ATP binding and hydrolysis-driven rate-determining events in the RFC-catalyzed PCNA clamp loading reaction. Journal of Molecular Biology. 416: 176-91. PMID 22197378 DOI: 10.1016/j.jmb.2011.12.018  1
2012 Sakato M, O'Donnell M, Hingorani MM. A central swivel point in the RFC clamp loader controls PCNA opening and loading on DNA. Journal of Molecular Biology. 416: 163-75. PMID 22197374 DOI: 10.1016/j.jmb.2011.12.017  0.68
2011 Pieniazek SN, Hingorani MM, Beveridge DL. Dynamical allosterism in the mechanism of action of DNA mismatch repair protein MutS. Biophysical Journal. 101: 1730-9. PMID 21961599 DOI: 10.1016/j.bpj.2011.08.039  1
2011 Heinen CD, Cyr JL, Cook C, Punja N, Sakato M, Forties RA, Lopez JM, Hingorani MM, Fishel R. Human MSH2 (hMSH2) protein controls ATP processing by hMSH2-hMSH6. The Journal of Biological Chemistry. 286: 40287-95. PMID 21937421 DOI: 10.1074/jbc.M111.297523  1
2010 Biro FN, Zhai J, Doucette CW, Hingorani MM. Application of stopped-flow kinetics methods to investigate the mechanism of action of a DNA repair protein. Journal of Visualized Experiments : Jove. PMID 20357752 DOI: 10.3791/1874  1
2010 Zhai J, Hingorani MM. Saccharomyces cerevisiae Msh2-Msh6 DNA binding kinetics reveal a mechanism of targeting sites for DNA mismatch repair. Proceedings of the National Academy of Sciences of the United States of America. 107: 680-5. PMID 20080735 DOI: 10.1073/pnas.0908302107  1
2009 Levin MK, Hingorani MM, Holmes RM, Patel SS, Carson JH. Model-based global analysis of heterogeneous experimental data using gfit. Methods in Molecular Biology (Clifton, N.J.). 500: 335-59. PMID 19399438 DOI: 10.1007/978-1-59745-525-1_12  1
2009 Wieland M, Levin MK, Hingorani KS, Biro FN, Hingorani MM. Mechanism of cadmium-mediated inhibition of Msh2-Msh6 function in DNA mismatch repair. Biochemistry. 48: 9492-502. PMID 19320425 DOI: 10.1021/bi9001248  1
2009 Chen S, Levin MK, Sakato M, Zhou Y, Hingorani MM. Mechanism of ATP-driven PCNA clamp loading by S. cerevisiae RFC. Journal of Molecular Biology. 388: 431-42. PMID 19285992 DOI: 10.1016/j.jmb.2009.03.014  1
2008 Freudenthal BD, Ramaswamy S, Hingorani MM, Washington MT. Structure of a mutant form of proliferating cell nuclear antigen that blocks translesion DNA synthesis. Biochemistry. 47: 13354-61. PMID 19053247 DOI: 10.1021/bi8017762  1
2008 Tessmer I, Yang Y, Zhai J, Du C, Hsieh P, Hingorani MM, Erie DA. Mechanism of MutS searching for DNA mismatches and signaling repair. The Journal of Biological Chemistry. 283: 36646-54. PMID 18854319 DOI: 10.1074/jbc.M805712200  1
2008 Chen S, Coman MM, Sakato M, O'Donnell M, Hingorani MM. Conserved residues in the δ subunit help the E. coli clamp loader, γ complex, target primer-template DNA for clamp assembly Nucleic Acids Research. 36: 3274-3286. PMID 18424802 DOI: 10.1093/nar/gkn157  1
2006 Antony E, Khubchandani S, Chen S, Hingorani MM. Contribution of Msh2 and Msh6 subunits to the asymmetric ATPase and DNA mismatch binding activities of Saccharomyces cerevisiae Msh2-Msh6 mismatch repair protein. Dna Repair. 5: 153-62. PMID 16214425 DOI: 10.1016/j.dnarep.2005.08.016  1
2005 Zito CR, Antony E, Hunt JF, Oliver DB, Hingorani MM. Role of a conserved glutamate residue in the Escherichia coli SecA ATPase mechanism Journal of Biological Chemistry. 280: 14611-14619. PMID 15710614 DOI: 10.1074/jbc.M414224200  1
2004 Antony E, Hingorani MM. Asymmetric ATP binding and hydrolysis activity of the Thermus aquaticus MutS dimer is key to modulation of its interactions with mismatched DNA. Biochemistry. 43: 13115-28. PMID 15476405 DOI: 10.1021/bi049010t  1
2004 Magdalena Coman M, Jin M, Ceapa R, Finkelstein J, O'Donnell M, Chait BT, Hingorani MM. Dual functions, clamp opening and primer-template recognition, define a key clamp loader subunit. Journal of Molecular Biology. 342: 1457-69. PMID 15364574 DOI: 10.1016/j.jmb.2004.07.097  1
2003 Yao N, Coryell L, Zhang D, Georgescu RE, Finkelstein J, Coman MM, Hingorani MM, O'Donnell M. Replication factor C clamp loader subunit arrangement within the circular pentamer and its attachment points to proliferating cell nuclear antigen. The Journal of Biological Chemistry. 278: 50744-53. PMID 14530260 DOI: 10.1074/jbc.M309206200  1
2003 Finkelstein J, Antony E, Hingorani MM, O'Donnell M. Overproduction and analysis of eukaryotic multiprotein complexes in Escherichia coli using a dual-vector strategy. Analytical Biochemistry. 319: 78-87. PMID 12842110 DOI: 10.1016/S0003-2697(03)00273-2  1
2003 Antony E, Hingorani MM. Mismatch recognition-coupled stabilization of Msh2-Msh6 in an ATP-bound state at the initiation of DNA repair. Biochemistry. 42: 7682-93. PMID 12820877 DOI: 10.1021/bi034602h  1
2003 Ason B, Handayani R, Williams CR, Bertram JG, Hingorani MM, O'Donnell M, Goodman MF, Bloom LB. Mechanism of loading the Escherichia coli DNA polymerase III beta sliding clamp on DNA. Bona fide primer/templates preferentially trigger the gamma complex to hydrolyze ATP and load the clamp. The Journal of Biological Chemistry. 278: 10033-40. PMID 12519754 DOI: 10.1074/jbc.M211741200  1
2002 Hingorani MM, Coman MM. On the specificity of interaction between the Saccharomyces cerevisiae clamp loader replication factor C and primed DNA templates during DNA replication. The Journal of Biological Chemistry. 277: 47213-24. PMID 12370190 DOI: 10.1074/jbc.M206764200  1
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