Louis B. Hersh - Publications

University of Kentucky, Lexington, KY 

59 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Chow KM, Whiteheart SW, Smiley JR, Sharma S, Boaz K, Coleman MJ, Maynard A, Hersh LB, Vander Kooi CW. Immunization of Alpacas (Lama pacos) with Protein Antigens and Production of Antigen-specific Single Domain Antibodies. Journal of Visualized Experiments : Jove. PMID 30741259 DOI: 10.3791/58471  0.56
2018 Song ES, Rodgers DW, Hersh LB. Insulin-degrading enzyme is not secreted from cultured cells. Scientific Reports. 8: 2335. PMID 29402917 DOI: 10.1038/s41598-018-20597-6  0.36
2017 Song ES, Jang H, Guo HF, Juliano MA, Juliano L, Morris AJ, Galperin E, Rodgers DW, Hersh LB. Inositol phosphates and phosphoinositides activate insulin-degrading enzyme, while phosphoinositides also mediate binding to endosomes. Proceedings of the National Academy of Sciences of the United States of America. PMID 28325868 DOI: 10.1073/pnas.1613447114  0.36
2015 Guan H, Chow KM, Song E, Verma N, Despa F, Hersh LB. The Mitochondrial Peptidase Pitrilysin Degrades Islet Amyloid Polypeptide in Beta-Cells. Plos One. 10: e0133263. PMID 26191799 DOI: 10.1371/journal.pone.0133263  0.56
2015 Song ES, Ozbil M, Zhang T, Sheetz M, Lee D, Tran D, Li S, Prabhakar R, Hersh LB, Rodgers DW. An Extended Polyanion Activation Surface in Insulin Degrading Enzyme. Plos One. 10: e0133114. PMID 26186535 DOI: 10.1371/journal.pone.0133114  0.36
2015 Parthasarathy R, Chow KM, Derafshi Z, Fautsch MP, Hetling JR, Rodgers DW, Hersh LB, Pepperberg DR. Reduction of amyloid-beta levels in mouse eye tissues by intra-vitreally delivered neprilysin. Experimental Eye Research. PMID 26142956 DOI: 10.1016/j.exer.2015.06.027  0.56
2015 Chin-Chan M, Segovia J, Quintanar L, Arcos-López T, Hersh LB, Chow KM, Rodgers DW, Quintanilla-Vega B. Mercury Reduces the Enzymatic Activity of Neprilysin in Differentiated SH-SY5Y Cells. Toxicological Sciences : An Official Journal of the Society of Toxicology. 145: 128-37. PMID 25673500 DOI: 10.1093/toxsci/kfv037  0.56
2014 Niedowicz DM, Reeves VL, Platt TL, Kohler K, Beckett TL, Powell DK, Lee TL, Sexton TR, Song ES, Brewer LD, Latimer CS, Kraner SD, Larson KL, Ozcan S, Norris CM, ... Hersh LB, et al. Obesity and diabetes cause cognitive dysfunction in the absence of accelerated β-amyloid deposition in a novel murine model of mixed or vascular dementia. Acta Neuropathologica Communications. 2: 64. PMID 24916066 DOI: 10.1186/2051-5960-2-64  0.56
2013 Karoor V, Oka M, Walchak SJ, Hersh LB, Miller YE, Dempsey EC. Neprilysin regulates pulmonary artery smooth muscle cell phenotype through a platelet-derived growth factor receptor-dependent mechanism. Hypertension. 61: 921-30. PMID 23381789 DOI: 10.1161/HYPERTENSIONAHA.111.199588  0.56
2012 Song ES, Melikishvili M, Fried MG, Juliano MA, Juliano L, Rodgers DW, Hersh LB. Cysteine 904 is required for maximal insulin degrading enzyme activity and polyanion activation. Plos One. 7: e46790. PMID 23077523 DOI: 10.1371/journal.pone.0046790  0.56
2012 Guan H, Chow KM, Shah R, Rhodes CJ, Hersh LB. Degradation of islet amyloid polypeptide by neprilysin. Diabetologia. 55: 2989-98. PMID 22898766 DOI: 10.1007/s00125-012-2678-y  0.56
2012 Sexton T, Hitchcook LJ, Rodgers DW, Bradley LH, Hersh LB. Active site mutations change the cleavage specificity of neprilysin. Plos One. 7: e32343. PMID 22384224 DOI: 10.1371/journal.pone.0032343  0.56
2012 Holler CJ, Webb RL, Laux AL, Beckett TL, Niedowicz DM, Ahmed RR, Liu Y, Simmons CR, Dowling AL, Spinelli A, Khurgel M, Estus S, Head E, Hersh LB, Murphy MP. BACE2 expression increases in human neurodegenerative disease. The American Journal of Pathology. 180: 337-50. PMID 22074738 DOI: 10.1016/j.ajpath.2011.09.034  0.56
2012 Noinaj N, Song ES, Bhasin S, Alper BJ, Schmidt WK, Hersh LB, Rodgers DW. Anion activation site of insulin-degrading enzyme. The Journal of Biological Chemistry. 287: 48-57. PMID 22049080 DOI: 10.1074/jbc.M111.264614  0.56
2011 Noinaj N, Bhasin SK, Song ES, Scoggin KE, Juliano MA, Juliano L, Hersh LB, Rodgers DW. Identification of the allosteric regulatory site of insulysin. Plos One. 6: e20864. PMID 21731629 DOI: 10.1371/journal.pone.0020864  0.56
2011 Song ES, Rodgers DW, Hersh LB. Mixed dimers of insulin-degrading enzyme reveal a cis activation mechanism. The Journal of Biological Chemistry. 286: 13852-8. PMID 21343292 DOI: 10.1074/jbc.M110.191668  0.36
2011 Kessler JH, Khan S, Seifert U, Le Gall S, Chow KM, Paschen A, Bres-Vloemans SA, De Ru A, Van Montfoort N, Franken KLMC, Benckhuijsen WE, Brooks JM, Van Hall T, Ray K, Mulder A, ... ... Hersh LB, et al. Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes Nature Immunology. 12: 45-53. PMID 21151101 DOI: 10.1038/ni.1974  0.56
2011 Wick MJ, Buesing EJ, Wehling CA, Loomis ZL, Cool CD, Zamora MR, Miller YE, Colgan SP, Hersh LB, Voelkel NF, Dempsey EC. Decreased neprilysin and pulmonary vascular remodeling in chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine. 183: 330-40. PMID 20813891 DOI: 10.1164/rccm.201002-0154OC  0.56
2010 Chow KM, Guan H, Hersh LB. Aminopeptidases do not directly degrade tau protein. Molecular Neurodegeneration. 5: 48. PMID 21054848 DOI: 10.1186/1750-1326-5-48  0.56
2010 Liu Y, Studzinski C, Beckett T, Murphy MP, Klein RL, Hersh LB. Circulating neprilysin clears brain amyloid. Molecular and Cellular Neurosciences. 45: 101-7. PMID 20558294 DOI: 10.1016/j.mcn.2010.05.014  0.56
2010 Song ES, Rodgers DW, Hersh LB. A monomeric variant of insulin degrading enzyme (IDE) loses its regulatory properties Plos One. 5. PMID 20300529 DOI: 10.1371/journal.pone.0009719  0.56
2009 Liu Y, Studzinski C, Beckett T, Guan H, Hersh MA, Murphy MP, Klein R, Hersh LB. Expression of neprilysin in skeletal muscle reduces amyloid burden in a transgenic mouse model of Alzheimer disease. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 1381-6. PMID 19471248 DOI: 10.1038/mt.2009.115  0.56
2009 Dempsey EC, Wick MJ, Karoor V, Barr EJ, Tallman DW, Wehling CA, Walchak SJ, Laudi S, Le M, Oka M, Majka S, Cool CD, Fagan KA, Klemm DJ, Hersh LB, et al. Neprilysin null mice develop exaggerated pulmonary vascular remodeling in response to chronic hypoxia. The American Journal of Pathology. 174: 782-96. PMID 19234135 DOI: 10.2353/ajpath.2009.080345  0.56
2009 Chow KM, Gakh O, Payne IC, Juliano MA, Juliano L, Isaya G, Hersh LB. Mammalian pitrilysin: substrate specificity and mitochondrial targeting. Biochemistry. 48: 2868-77. PMID 19196155 DOI: 10.1021/bi8016125  0.56
2009 Rose JB, Crews L, Rockenstein E, Adame A, Mante M, Hersh LB, Gage FH, Spencer B, Potkar R, Marr RA, Masliah E. Neuropeptide Y fragments derived from neprilysin processing are neuroprotective in a transgenic model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 1115-25. PMID 19176820 DOI: 10.1523/JNEUROSCI.4220-08.2009  0.56
2009 Guan H, Liu Y, Daily A, Police S, Kim MH, Oddo S, LaFerla FM, Pauly JR, Murphy MP, Hersh LB. Peripherally expressed neprilysin reduces brain amyloid burden: a novel approach for treating Alzheimer's disease. Journal of Neuroscience Research. 87: 1462-73. PMID 19021293 DOI: 10.1002/jnr.21944  0.56
2008 Hersh LB, Rodgers DW. Neprilysin and amyloid beta peptide degradation Current Alzheimer Research. 5: 225-231. PMID 18393807 DOI: 10.2174/156720508783954703  0.56
2008 Horiguchi A, Chen DY, Goodman OB, Zheng R, Shen R, Guan H, Hersh LB, Nanus DM. Neutral endopeptidase inhibits prostate cancer tumorigenesis by reducing FGF-2-mediated angiogenesis. Prostate Cancer and Prostatic Diseases. 11: 79-87. PMID 17563767 DOI: 10.1038/sj.pcan.4500984  0.56
2007 Liu Y, Guan H, Beckett TL, Juliano MA, Juliano L, Song ES, Chow KM, Murphy MP, Hersh LB. In vitro and in vivo degradation of Abeta peptide by peptidases coupled to erythrocytes. Peptides. 28: 2348-55. PMID 17988763 DOI: 10.1016/j.peptides.2007.09.015  0.56
2007 Horiguchi A, Zheng R, Goodman OB, Shen R, Guan H, Hersh LB, Nanus DM. Lentiviral vector neutral endopeptidase gene transfer suppresses prostate cancer tumor growth. Cancer Gene Therapy. 14: 583-9. PMID 17415380 DOI: 10.1038/sj.cgt.7701047  0.56
2007 Kim M, Hersh LB, Leissring MA, Ingelsson M, Matsui T, Farris W, Lu A, Hyman BT, Selkoe DJ, Bertram L, Tanzi RE. Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families. The Journal of Biological Chemistry. 282: 7825-32. PMID 17244626 DOI: 10.1074/jbc.M609168200  0.56
2006 Song ES, Cady C, Fried MG, Hersh LB. Proteolytic fragments of insulysin (IDE) retain substrate binding but lose allosteric regulation. Biochemistry. 45: 15085-91. PMID 17154546 DOI: 10.1021/bi061298u  0.56
2006 Stricker R, Chow KM, Walther D, Hanck T, Hersh LB, Reiser G. Interaction of the brain-specific protein p42IP4/centaurin-alpha1 with the peptidase nardilysin is regulated by the cognate ligands of p42IP4, PtdIns(3,4,5)P3 and Ins(1,3,4,5)P4, with stereospecificity. Journal of Neurochemistry. 98: 343-54. PMID 16805830 DOI: 10.1111/j.1471-4159.2006.03869.x  0.56
2006 Shimojo M, Hersh LB. Characterization of the REST/NRSF-interacting LIM domain protein (RILP): localization and interaction with REST/NRSF. Journal of Neurochemistry. 96: 1130-8. PMID 16417580 DOI: 10.1111/j.1471-4159.2005.03608.x  0.56
2005 Shinall H, Song ES, Hersh LB. Susceptibility of amyloid beta peptide degrading enzymes to oxidative damage: a potential Alzheimer's disease spiral. Biochemistry. 44: 15345-50. PMID 16285738 DOI: 10.1021/bi050650l  0.32
2005 Chow KM, Ma Z, Cai J, Pierce WM, Hersh LB. Nardilysin facilitates complex formation between mitochondrial malate dehydrogenase and citrate synthase. Biochimica Et Biophysica Acta. 1723: 292-301. PMID 15809022 DOI: 10.1016/j.bbagen.2005.02.010  0.56
2005 Song ES, Hersh LB. Insulysin: an allosteric enzyme as a target for Alzheimer's disease. Journal of Molecular Neuroscience : Mn. 25: 201-6. PMID 15800373 DOI: 10.1385/JMN:25:3:201  0.56
2005 Lazarov O, Robinson J, Tang YP, Hairston IS, Korade-Mirnics Z, Lee VM, Hersh LB, Sapolsky RM, Mirnics K, Sisodia SS. Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice. Cell. 120: 701-13. PMID 15766532 DOI: 10.1016/j.cell.2005.01.015  0.56
2005 Song ES, Daily A, Fried MG, Juliano MA, Juliano L, Hersh LB. Mutation of active site residues of insulin-degrading enzyme alters allosteric interactions. The Journal of Biological Chemistry. 280: 17701-6. PMID 15749695 DOI: 10.1074/jbc.M501896200  0.56
2005 Nath A, Hersh LB. Tat and amyloid: multiple interactions. Aids (London, England). 19: 203-4. PMID 15668546  0.56
2004 Yao J, Erickson JD, Hersh LB. Protein kinase A affects trafficking of the vesicular monoamine transporters in PC12 cells. Traffic (Copenhagen, Denmark). 5: 1006-16. PMID 15522101 DOI: 10.1111/j.1600-0854.2004.00240.x  0.56
2004 Song ES, Juliano MA, Juliano L, Fried MG, Wagner SL, Hersh LB. ATP effects on insulin-degrading enzyme are mediated primarily through its triphosphate moiety. The Journal of Biological Chemistry. 279: 54216-20. PMID 15494400 DOI: 10.1074/jbc.M411177200  0.56
2004 Huang J, Guan H, Booze RM, Eckman CB, Hersh LB. Estrogen regulates neprilysin activity in rat brain. Neuroscience Letters. 367: 85-7. PMID 15308303 DOI: 10.1016/j.neulet.2004.05.085  0.56
2004 Cai Y, Cronin CN, Engel AG, Ohno K, Hersh LB, Rodgers DW. Choline acetyltransferase structure reveals distribution of mutations that cause motor Embo Journal. 23: 2047-2058. PMID 15131697 DOI: 10.1038/sj.emboj.7600221  0.56
2004 Shimojo M, Hersh LB. Regulation of the cholinergic gene locus by the repressor element-1 silencing transcription factor/neuron restrictive silencer factor (REST/NRSF). Life Sciences. 74: 2213-25. PMID 15017977 DOI: 10.1016/j.lfs.2003.08.045  0.56
2004 Ma Z, Chow KM, Yao J, Hersh LB. Nuclear shuttling of the peptidase nardilysin. Archives of Biochemistry and Biophysics. 422: 153-60. PMID 14759602 DOI: 10.1016/j.abb.2003.11.024  0.56
2004 Marr RA, Guan H, Rockenstein E, Kindy M, Gage FH, Verma I, Masliah E, Hersh LB. Neprilysin regulates amyloid Beta peptide levels. Journal of Molecular Neuroscience : Mn. 22: 5-11. PMID 14742905 DOI: 10.1385/JMN:22:1-2:5  0.56
2003 Thompson MW, Hersh LB. Analysis of conserved residues of the human puromycin-sensitive aminopeptidase. Peptides. 24: 1359-65. PMID 14706550 DOI: 10.1016/j.peptides.2003.07.012  0.56
2003 Shimojo M, Hersh LB. REST/NRSF-interacting LIM domain protein, a putative nuclear translocation receptor. Molecular and Cellular Biology. 23: 9025-31. PMID 14645515 DOI: 10.1128/MCB.23.24.9025-9031.2003  0.56
2003 Song ES, Juliano MA, Juliano L, Hersh LB. Substrate activation of insulin-degrading enzyme (insulysin). A potential target for drug development. The Journal of Biological Chemistry. 278: 49789-94. PMID 14527953 DOI: 10.1074/jbc.M308983200  0.32
2003 Miller BC, Eckman EA, Sambamurti K, Dobbs N, Chow KM, Eckman CB, Hersh LB, Thiele DL. Amyloid-beta peptide levels in brain are inversely correlated with insulysin activity levels in vivo. Proceedings of the National Academy of Sciences of the United States of America. 100: 6221-6. PMID 12732730 DOI: 10.1073/pnas.1031520100  0.56
2003 Thompson MW, Govindaswami M, Hersh LB. Mutation of active site residues of the puromycin-sensitive aminopeptidase: conversion of the enzyme into a catalytically inactive binding protein. Archives of Biochemistry and Biophysics. 413: 236-42. PMID 12729622 DOI: 10.1016/S0003-9861(03)00123-1  0.56
2003 Yamada ES, Dmitrieva N, Keyser KT, Lindstrom JM, Hersh LB, Marshak DW. Synaptic connections of starburst amacrine cells and localization of acetylcholine receptors in primate retinas. The Journal of Comparative Neurology. 461: 76-90. PMID 12722106 DOI: 10.1002/cne.10672  0.56
2003 Kim MH, Lu M, Rogers G, Parsons S, Hersh LB. Specificity of the rat vesicular acetylcholine transporter. Neurochemical Research. 28: 473-6. PMID 12675133 DOI: 10.1023/A:1022804903088  0.56
2003 Marr RA, Rockenstein E, Mukherjee A, Kindy MS, Hersh LB, Gage FH, Verma IM, Masliah E. Neprilysin gene transfer reduces human amyloid pathology in transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 1992-6. PMID 12657655  0.56
2003 Hersh LB, Shimojo M. Regulation of cholinergic gene expression by the neuron restrictive silencer factor/repressor element-1 silencing transcription factor. Life Sciences. 72: 2021-8. PMID 12628452 DOI: 10.1016/S0024-3205(03)00065-1  0.56
2003 Chow KM, Oakley O, Goodman J, Ma Z, Juliano MA, Juliano L, Hersh LB. Nardilysin cleaves peptides at monobasic sites. Biochemistry. 42: 2239-44. PMID 12590613 DOI: 10.1021/bi027178d  0.56
2002 Ma Z, Chow KM, Csuhai E, Hersh LB. The use of proteolysis to study the structure of nardilysin. Archives of Biochemistry and Biophysics. 401: 198-204. PMID 12054470 DOI: 10.1016/S0003-9861(02)00020-6  0.56
2002 Fischer HS, Zernig G, Hauser KF, Gerard C, Hersh LB, Saria A. Neutral endopeptidase knockout induces hyperalgesia in a model of visceral pain, an effect related to bradykinin and nitric oxide. Journal of Molecular Neuroscience : Mn. 18: 129-34. PMID 11931342 DOI: 10.1385/JMN:18:1-2:129  0.56
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