Joseph T. Jarrett - Publications

University of Pennsylvania, Philadelphia, PA, United States 

38 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Tao L, Stich TA, Fugate CJ, Jarrett JT, Britt RD. EPR-Derived Structure of a Paramagnetic Intermediate Generated by Biotin Synthase BioB. Journal of the American Chemical Society. PMID 30222930 DOI: 10.1021/Jacs.8B07613  0.56
2015 Jarrett JT. The biosynthesis of thiol- and thioether-containing cofactors and secondary metabolites catalyzed by radical S-adenosylmethionine enzymes. The Journal of Biological Chemistry. 290: 3972-9. PMID 25477512 DOI: 10.1074/jbc.R114.599308  1
2014 Jarrett JT. Biotin synthase: A role for iron-sulfur clusters in the radical-mediated generation of carbon-sulfur bonds Iron-Sulfur Clusters in Chemistry and Biology. 107-132. DOI: 10.1515/9783110308426.107  1
2012 Fugate CJ, Stich TA, Kim EG, Myers WK, Britt RD, Jarrett JT. 9-Mercaptodethiobiotin is generated as a ligand to the [2Fe-2S]+ cluster during the reaction catalyzed by biotin synthase from Escherichia coli. Journal of the American Chemical Society. 134: 9042-5. PMID 22607542 DOI: 10.1021/Ja3012963  1
2012 Fugate CJ, Jarrett JT. Biotin synthase: insights into radical-mediated carbon-sulfur bond formation. Biochimica Et Biophysica Acta. 1824: 1213-22. PMID 22326745 DOI: 10.1016/j.bbapap.2012.01.010  0.56
2011 Taylor AM, Stoll S, Britt RD, Jarrett JT. Reduction of the [2Fe-2S] cluster accompanies formation of the intermediate 9-mercaptodethiobiotin in Escherichia coli biotin synthase. Biochemistry. 50: 7953-63. PMID 21859080 DOI: 10.1021/Bi201042R  1
2010 Farrar CE, Siu KK, Howell PL, Jarrett JT. Biotin synthase exhibits burst kinetics and multiple turnovers in the absence of inhibition by products and product-related biomolecules. Biochemistry. 49: 9985-96. PMID 20961145 DOI: 10.1021/bi101023c  1
2009 Reyda MR, Fugate CJ, Jarrett JT. A complex between biotin synthase and the iron-sulfur cluster assembly chaperone HscA that enhances in vivo cluster assembly. Biochemistry. 48: 10782-92. PMID 19821612 DOI: 10.1021/Bi901393T  1
2009 Drennan CL, Jarrett JT. From single molecules to whole organisms: the evolving field of mechanistic enzymology. Current Opinion in Chemical Biology. 13: 433-5. PMID 19740697 DOI: 10.1016/J.Cbpa.2009.08.004  1
2009 Farrar CE, Jarrett JT. Protein residues that control the reaction trajectory in S-adenosylmethionine radical enzymes: mutagenesis of asparagine 153 and aspartate 155 in Escherichia coli biotin synthase. Biochemistry. 48: 2448-58. PMID 19199517 DOI: 10.1021/bi8022569  1
2008 Taylor AM, Farrar CE, Jarrett JT. 9-Mercaptodethiobiotin is formed as a competent catalytic intermediate by Escherichia coli biotin synthase. Biochemistry. 47: 9309-17. PMID 18690713 DOI: 10.1021/bi801035b  1
2008 Jarrett JT. Biochemistry: radicals by reduction. Nature. 452: 163-4. PMID 18337811 DOI: 10.1038/452163a  1
2008 Reyda MR, Dippold R, Dotson ME, Jarrett JT. Loss of iron-sulfur clusters from biotin synthase as a result of catalysis promotes unfolding and degradation. Archives of Biochemistry and Biophysics. 471: 32-41. PMID 18155152 DOI: 10.1016/J.Abb.2007.12.001  1
2006 Broach RB, Jarrett JT. Role of the [2Fe-2S]2+ cluster in biotin synthase: mutagenesis of the atypical metal ligand arginine 260. Biochemistry. 45: 14166-74. PMID 17115711 DOI: 10.1021/bi061576p  1
2005 Jarrett JT. Biotin synthase: enzyme or reactant? Chemistry & Biology. 12: 409-10. PMID 15850974 DOI: 10.1016/J.Chembiol.2005.04.003  1
2005 Jarrett JT. The novel structure and chemistry of iron-sulfur clusters in the adenosylmethionine-dependent radical enzyme biotin synthase. Archives of Biochemistry and Biophysics. 433: 312-21. PMID 15581586 DOI: 10.1016/J.Abb.2004.10.003  1
2004 Berkovitch F, Nicolet Y, Wan JT, Jarrett JT, Drennan CL. Crystal structure of biotin synthase, an S-adenosylmethionine-dependent radical enzyme. Science (New York, N.Y.). 303: 76-9. PMID 14704425 DOI: 10.1126/Science.1088493  1
2003 Jarrett JT. The generation of 5'-deoxyadenosyl radicals by adenosylmethionine-dependent radical enzymes. Current Opinion in Chemical Biology. 7: 174-82. PMID 12714049 DOI: 10.1016/S1367-5931(03)00022-X  1
2003 Ugulava NB, Frederick KK, Jarrett JT. Control of adenosylmethionine-dependent radical generation in biotin synthase: a kinetic and thermodynamic analysis of substrate binding to active and inactive forms of BioB. Biochemistry. 42: 2708-19. PMID 12614166 DOI: 10.1021/Bi0261084  1
2002 Jarrett JT, Wan JT. Thermal inactivation of reduced ferredoxin (flavodoxin):NADP+ oxidoreductase from Escherichia coli. Febs Letters. 529: 237-42. PMID 12372607 DOI: 10.1016/S0014-5793(02)03349-5  1
2002 Wan JT, Jarrett JT. Electron acceptor specificity of ferredoxin (flavodoxin):NADP+ oxidoreductase from Escherichia coli. Archives of Biochemistry and Biophysics. 406: 116-26. PMID 12234497 DOI: 10.1016/S0003-9861(02)00421-6  1
2001 Ugulava NB, Gibney BR, Jarrett JT. Biotin synthase contains two distinct iron-sulfur cluster binding sites: chemical and spectroelectrochemical analysis of iron-sulfur cluster interconversions. Biochemistry. 40: 8343-51. PMID 11444981 DOI: 10.1021/Bi0104625  1
2000 Ugulava NB, Gibney BR, Jarrett JT. Iron-sulfur cluster interconversions in biotin synthase: dissociation and reassociation of iron during conversion of [2Fe-2S] to [4Fe-4S] clusters. Biochemistry. 39: 5206-14. PMID 10819988 DOI: 10.1021/Bi9926227  1
1998 Jarrett JT, Hoover DM, Ludwig ML, Matthews RG. The mechanism of adenosylmethionine-dependent activation of methionine synthase: a rapid kinetic analysis of intermediates in reductive methylation of Cob(II)alamin enzyme. Biochemistry. 37: 12649-58. PMID 9730838 DOI: 10.1021/Bi9808565  1
1998 Jarrett JT, Huang S, Matthews RG. Methionine synthase exists in two distinct conformations that differ in reactivity toward methyltetrahydrofolate, adenosylmethionine, and flavodoxin. Biochemistry. 37: 5372-82. PMID 9548919 DOI: 10.1021/Bi9730893  1
1998 Walker LA, Jarrett JT, Anderson NA, Pullen SH, Matthews RG, Sension RJ. Time-resolved spectroscopic studies of B12 coenzymes: The identification of a metastable Cob(III)alamin photoproduct in the photolysis of methylcobalamin Journal of the American Chemical Society. 120: 3597-3603. DOI: 10.1021/Ja974024Q  1
1997 Jarrett JT, Choi CY, Matthews RG. Changes in protonation associated with substrate binding and Cob(I)alamin formation in cobalamin-dependent methionine synthase. Biochemistry. 36: 15739-48. PMID 9398303 DOI: 10.1021/Bi971987T  1
1997 Jarrett JT, Goulding CW, Fluhr K, Huang S, Matthews RG. Purification and assay of cobalamin-dependent methionine synthase from Escherichia coli. Methods in Enzymology. 281: 196-213. PMID 9250984 DOI: 10.1016/S0076-6879(97)81026-9  1
1997 Hoover DM, Jarrett JT, Sands RH, Dunham WR, Ludwig ML, Matthews RG. Interaction of Escherichia coli cobalamin-dependent methionine synthase and its physiological partner flavodoxin: binding of flavodoxin leads to axial ligand dissociation from the cobalamin cofactor. Biochemistry. 36: 127-38. PMID 8993326 DOI: 10.1021/Bi961693S  1
1996 Jarrett JT, Drennan CL, Amaratunga M, Scholten JD, Ludwig ML, Matthews RG. A protein radical cage slows photolysis of methylcobalamin in methionine synthase from Escherichia coli. Bioorganic & Medicinal Chemistry. 4: 1237-46. PMID 8879545 DOI: 10.1016/0968-0896(96)00119-8  1
1996 Jarrett JT, Amaratunga M, Drennan CL, Scholten JD, Sands RH, Ludwig ML, Matthews RG. Mutations in the B12-binding region of methionine synthase: how the protein controls methylcobalamin reactivity. Biochemistry. 35: 2464-75. PMID 8652590 DOI: 10.1021/Bi952389M  1
1996 Amaratunga M, Fluhr K, Jarrett JT, Drennan CL, Ludwig ML, Matthews RG, Scholten JD. A synthetic module for the metH gene permits facile mutagenesis of the cobalamin-binding region of Escherichia coli methionine synthase: initial characterization of seven mutant proteins. Biochemistry. 35: 2453-63. PMID 8652589 DOI: 10.1021/Bi952388U  1
1995 Lipman RS, Bailey SW, Jarrett JT, Matthews RG, Jorns MS. Stereospecificity of folate binding to DNA photolyase from Escherichia coli. Biochemistry. 34: 11217-20. PMID 7669779 DOI: 10.1021/Bi00035A030  1
1993 Jarrett JT, Lansbury PT. Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie? Cell. 73: 1055-8. PMID 8513491 DOI: 10.1016/0092-8674(93)90635-4  1
1993 Jarrett JT, Berger EP, Lansbury PT. The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease. Biochemistry. 32: 4693-7. PMID 8490014 DOI: 10.1021/Bi00069A001  1
1993 Jarrett JT, Berger EP, Lansbury PT. The C-terminus of the beta protein is critical in amyloidogenesis. Annals of the New York Academy of Sciences. 695: 144-8. PMID 8239273 DOI: 10.1111/J.1749-6632.1993.Tb23043.X  1
1992 Jarrett JT, Lansbury PT. Amyloid fibril formation requires a chemically discriminating nucleation event: studies of an amyloidogenic sequence from the bacterial protein OsmB. Biochemistry. 31: 12345-52. PMID 1463722 DOI: 10.1021/Bi00164A008  1
1990 Jarrett JT, Lansbury PT. Improved coupling of protected peptides on the kaiser oxime resin using bop activation Tetrahedron Letters. 31: 4561-4564. DOI: 10.1016/S0040-4039(00)97676-7  1
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