Ronald E. Viola - Publications

1989-2000 The University of Akron 
 2000- The University of Toledo 

72 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Parungao GG, Zhao M, Wang Q, Zano SP, Viola RE, Blumenthal RM. Complementation of a metK-deficient E. coli strain with heterologous AdoMet synthetase genes. Microbiology (Reading, England). PMID 29111970 DOI: 10.1099/mic.0.000565  0.68
2016 Coburn KM, Wang Q, Rediske D, Viola RE, Hanson BL, Xue Z, Seo YY. Effects of extracellular polymeric substance composition on bacteria disinfection by monochloramine: Application of MALDI-TOF-MS and Multivariate Analysis. Environmental Science & Technology. PMID 27366970 DOI: 10.1021/acs.est.6b00927  0.44
2016 Li Q, Mu Z, Zhao R, Dahal G, Viola RE, Liu T, Jin Q, Cui S. Structural Insights into the Tetrameric State of Aspartate-β-semialdehyde Dehydrogenases from Fungal Species. Scientific Reports. 6: 21067. PMID 26869335 DOI: 10.1038/srep21067  0.48
2015 Wang Q, Zhao M, Parungao G, Viola RE. Purification and Characterization of Aspartate N-acetyltransferase: a critical enzyme in brain metabolism. Protein Expression and Purification. PMID 26550943 DOI: 10.1016/j.pep.2015.11.001  0.48
2015 Thangavelu B, Bhansali P, Viola RE. Elaboration of a fragment library hit produces potent and selective aspartate semialdehyde dehydrogenase inhibitors. Bioorganic & Medicinal Chemistry. 23: 6622-31. PMID 26404410 DOI: 10.1016/j.bmc.2015.09.017  0.48
2015 Zhao M, Wijayasinghe YS, Bhansali P, Viola RE, Blumenthal RM. A surprising range of modified-methionyl S-adenosylmethionine analogues support bacterial growth. Microbiology (Reading, England). 161: 674-82. PMID 25717169 DOI: 10.1099/mic.0.000034  0.44
2014 Pavlovsky AG, Thangavelu B, Bhansali P, Viola RE. A cautionary tale of structure-guided inhibitor development against an essential enzyme in the aspartate-biosynthetic pathway. Acta Crystallographica. Section D, Biological Crystallography. 70: 3244-52. PMID 25478842 DOI: 10.1107/S1399004714023979  0.48
2014 Poddar NK, Zano S, Natarajan R, Yamamoto B, Viola RE. Enhanced brain distribution of modified aspartoacylase. Molecular Genetics and Metabolism. 113: 219-24. PMID 25066302 DOI: 10.1016/j.ymgme.2014.07.002  0.44
2014 Wijayasinghe YS, Pavlovsky AG, Viola RE. Aspartoacylase catalytic deficiency as the cause of Canavan disease: a structural perspective. Biochemistry. 53: 4970-8. PMID 25003821 DOI: 10.1021/bi500719k  0.68
2014 Zano SP, Pavlovsky AG, Viola RE. Structure of an unusual S-adenosylmethionine synthetase from Campylobacter jejuni. Acta Crystallographica. Section D, Biological Crystallography. 70: 442-50. PMID 24531478 DOI: 10.1107/S139900471303023X  0.68
2014 Wijayasinghe YS, Blumenthal RM, Viola RE. Producing proficient methyl donors from alternative substrates of S-adenosylmethionine synthetase. Biochemistry. 53: 1521-6. PMID 24528526 DOI: 10.1021/bi401556p  0.44
2013 Zano SP, Bhansali P, Luniwal A, Viola RE. Alternative substrates selective for S-adenosylmethionine synthetases from pathogenic bacteria. Archives of Biochemistry and Biophysics. 536: 64-71. PMID 23711747 DOI: 10.1016/  0.44
2013 Zano S, Wijayasinghe YS, Malik R, Smith J, Viola RE. Relationship between enzyme properties and disease progression in Canavan disease. Journal of Inherited Metabolic Disease. 36: 1-6. PMID 22850825 DOI: 10.1007/s10545-012-9520-z  0.36
2012 Arachea BT, Sun Z, Potente N, Malik R, Isailovic D, Viola RE. Detergent selection for enhanced extraction of membrane proteins. Protein Expression and Purification. 86: 12-20. PMID 22963795 DOI: 10.1016/j.pep.2012.08.016  0.44
2012 Luniwal A, Wang L, Pavlovsky A, Erhardt PW, Viola RE. Molecular docking and enzymatic evaluation to identify selective inhibitors of aspartate semialdehyde dehydrogenase. Bioorganic & Medicinal Chemistry. 20: 2950-6. PMID 22464683 DOI: 10.1016/j.bmc.2012.03.013  0.44
2012 Sarver JG, Trendel JA, Bearss NR, Wang L, Luniwal A, Erhardt PW, Viola RE. Early stage efficacy and toxicology screening for antibiotics and enzyme inhibitors. Journal of Biomolecular Screening. 17: 673-82. PMID 22460173 DOI: 10.1177/1087057112438769  0.44
2012 Pavlovsky AG, Liu X, Faehnle CR, Potente N, Viola RE. Structural characterization of inhibitors with selectivity against members of a homologous enzyme family. Chemical Biology & Drug Design. 79: 128-36. PMID 22039970 DOI: 10.1111/j.1747-0285.2011.01267.x  0.8
2011 Viola RE, Faehnle CR, Blanco J, Moore RA, Liu X, Arachea BT, Pavlovsky AG. The catalytic machinery of a key enzyme in amino Acid biosynthesis. Journal of Amino Acids. 2011: 352538. PMID 22332000 DOI: 10.4061/2011/352538  1
2011 Saribas AS, Arachea BT, White MK, Viola RE, Safak M. Human polyomavirus JC small regulatory agnoprotein forms highly stable dimers and oligomers: implications for their roles in agnoprotein function. Virology. 420: 51-65. PMID 21920573 DOI: 10.1016/j.virol.2011.08.015  0.48
2011 Tawfik DS, Viola RE. Arsenate replacing phosphate: alternative life chemistries and ion promiscuity. Biochemistry. 50: 1128-34. PMID 21214261 DOI: 10.1021/bi200002a  0.48
2011 Zano S, Malik R, Szucs S, Matalon R, Viola RE. Modification of aspartoacylase for potential use in enzyme replacement therapy for the treatment of Canavan disease. Molecular Genetics and Metabolism. 102: 176-80. PMID 21095151 DOI: 10.1016/j.ymgme.2010.10.012  0.36
2010 Gao G, Liu X, Pavlovsky A, Viola RE. Identification of selective enzyme inhibitors by fragment library screening. Journal of Biomolecular Screening. 15: 1042-50. PMID 20855558 DOI: 10.1177/1087057110381383  0.64
2010 Malik R, Viola RE. Structural characterization of tartrate dehydrogenase: a versatile enzyme catalyzing multiple reactions. Acta Crystallographica. Section D, Biological Crystallography. 66: 673-84. PMID 20516620 DOI: 10.1107/S0907444910008851  0.36
2010 Arachea BT, Liu X, Pavlovsky AG, Viola RE. Expansion of the aspartate beta-semialdehyde dehydrogenase family: the first structure of a fungal ortholog. Acta Crystallographica. Section D, Biological Crystallography. 66: 205-12. PMID 20124701 DOI: 10.1107/S0907444909052834  0.68
2009 Bearden SW, Sexton C, Pare J, Fowler JM, Arvidson CG, Yerman L, Viola RE, Brubaker RR. Attenuated enzootic (pestoides) isolates of Yersinia pestis express active aspartase. Microbiology (Reading, England). 155: 198-209. PMID 19118360 DOI: 10.1099/mic.0.021170-0  0.48
2008 Viola RE, Yerman L, Fowler JM, Arvidson CG, Brubaker RR. A missense mutation causes aspartase deficiency in Yersinia pestis. Microbiology (Reading, England). 154: 1271-80. PMID 18451035 DOI: 10.1099/mic.0.2007/015529-0  0.48
2008 Liu X, Pavlovsky AG, Viola RE. The structural basis for allosteric inhibition of a threonine-sensitive aspartokinase. The Journal of Biological Chemistry. 283: 16216-25. PMID 18334478 DOI: 10.1074/jbc.M800760200  0.68
2008 Viola RE, Liu X, Ohren JF, Faehnle CR. The structure of a redundant enzyme: a second isoform of aspartate beta-semialdehyde dehydrogenase in Vibrio cholerae. Acta Crystallographica. Section D, Biological Crystallography. 64: 321-30. PMID 18323627 DOI: 10.1107/S0907444907068552  0.8
2008 Le Coq J, Pavlovsky A, Malik R, Sanishvili R, Xu C, Viola RE. Examination of the mechanism of human brain aspartoacylase through the binding of an intermediate analogue. Biochemistry. 47: 3484-92. PMID 18293939 DOI: 10.1021/bi702400x  0.76
2007 Liu X, Hanson BL, Langan P, Viola RE. The effect of deuteration on protein structure: a high-resolution comparison of hydrogenous and perdeuterated haloalkane dehalogenase. Acta Crystallographica. Section D, Biological Crystallography. 63: 1000-8. PMID 17704569 DOI: 10.1107/S0907444907037705  0.64
2007 Coe DM, Viola RE. Assessing the roles of essential functional groups in the mechanism of homoserine succinyltransferase. Archives of Biochemistry and Biophysics. 461: 211-8. PMID 17442255 DOI: 10.1016/  0.76
2007 Ohren JF, Kundracik ML, Borders CL, Edmiston P, Viola RE. Structural asymmetry and intersubunit communication in muscle creatine kinase. Acta Crystallographica. Section D, Biological Crystallography. 63: 381-9. PMID 17327675 DOI: 10.1107/S0907444906056204  0.48
2006 Faehnle CR, Liu X, Pavlovsky A, Viola RE. The initial step in the archaeal aspartate biosynthetic pathway catalyzed by a monofunctional aspartokinase. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 62: 962-6. PMID 17012784 DOI: 10.1107/S1744309106038279  0.8
2006 Faehnle CR, Le Coq J, Liu X, Viola RE. Examination of key intermediates in the catalytic cycle of aspartate-beta-semialdehyde dehydrogenase from a gram-positive infectious bacteria. The Journal of Biological Chemistry. 281: 31031-40. PMID 16895909 DOI: 10.1074/jbc.M605926200  0.8
2006 Le Coq J, An HJ, Lebrilla C, Viola RE. Characterization of human aspartoacylase: the brain enzyme responsible for Canavan disease. Biochemistry. 45: 5878-84. PMID 16669630 DOI: 10.1021/bi052608w  0.48
2006 Liu Q, Kirchhoff JR, Faehnle CR, Viola RE, Hudson RA. A rapid method for the purification of methanol dehydrogenase from Methylobacterium extorquens. Protein Expression and Purification. 46: 316-20. PMID 16139516 DOI: 10.1016/j.pep.2005.07.014  0.48
2005 Colleluori DM, Reczkowski RS, Emig FA, Cama E, Cox JD, Scolnick LR, Compher K, Jude K, Han S, Viola RE, Christianson DW, Ash DE. Probing the role of the hyper-reactive histidine residue of arginase. Archives of Biochemistry and Biophysics. 444: 15-26. PMID 16266687 DOI: 10.1016/  0.48
2005 Faehnle CR, Ohren JF, Viola RE. A new branch in the family: structure of aspartate-beta-semialdehyde dehydrogenase from Methanococcus jannaschii. Journal of Molecular Biology. 353: 1055-68. PMID 16225889 DOI: 10.1016/j.jmb.2005.09.027  0.8
2004 Faehnle CR, Blanco J, Viola RE. Structural basis for discrimination between oxyanion substrates or inhibitors in aspartate-beta-semialdehyde dehydrogenase. Acta Crystallographica. Section D, Biological Crystallography. 60: 2320-4. PMID 15583380 DOI: 10.1107/S0907444904026411  1
2004 Blanco J, Moore RA, Faehnle CR, Viola RE. Critical catalytic functional groups in the mechanism of aspartate-beta-semialdehyde dehydrogenase. Acta Crystallographica. Section D, Biological Crystallography. 60: 1808-15. PMID 15388927 DOI: 10.1107/S0907444904020104  1
2004 Blanco J, Moore RA, Faehnle CR, Coe DM, Viola RE. The role of substrate-binding groups in the mechanism of aspartate-beta-semialdehyde dehydrogenase. Acta Crystallographica. Section D, Biological Crystallography. 60: 1388-95. PMID 15272161 DOI: 10.1107/S0907444904012971  1
2004 Cama E, Pethe S, Boucher JL, Han S, Emig FA, Ash DE, Viola RE, Mansuy D, Christianson DW. Inhibitor coordination interactions in the binuclear manganese cluster of arginase. Biochemistry. 43: 8987-99. PMID 15248756 DOI: 10.1021/bi0491705  0.48
2004 Han S, Viola RE. Splicing of unnatural amino acids into proteins: a peptide model study. Protein and Peptide Letters. 11: 107-14. PMID 15078198  0.96
2004 Madhavarao CN, Moffett JR, Moore RA, Viola RE, Namboodiri MA, Jacobowitz DM. Immunohistochemical localization of aspartoacylase in the rat central nervous system. The Journal of Comparative Neurology. 472: 318-29. PMID 15065127 DOI: 10.1002/cne.20080  0.76
2004 Elder I, Han S, Tu C, Steele H, Laipis PJ, Viola RE, Silverman DN. Activation of carbonic anhydrase II by active-site incorporation of histidine analogs. Archives of Biochemistry and Biophysics. 421: 283-9. PMID 14984209  0.96
2003 Blanco J, Moore RA, Viola RE. Capture of an intermediate in the catalytic cycle of L-aspartate-beta-semialdehyde dehydrogenase. Proceedings of the National Academy of Sciences of the United States of America. 100: 12613-7. PMID 14559965 DOI: 10.1073/pnas.1634958100  1
2003 Moore RA, Le Coq J, Faehnle CR, Viola RE. Purification and preliminary characterization of brain aspartoacylase. Archives of Biochemistry and Biophysics. 413: 1-8. PMID 12706335  0.8
2003 Blanco J, Moore RA, Kabaleeswaran V, Viola RE. A structural basis for the mechanism of aspartate-beta-semialdehyde dehydrogenase from Vibrio cholerae. Protein Science : a Publication of the Protein Society. 12: 27-33. PMID 12493825  1
2002 Moore RA, Bocik WE, Viola RE. Expression and purification of aspartate beta-semialdehyde dehydrogenase from infectious microorganisms. Protein Expression and Purification. 25: 189-94. PMID 12071715 DOI: 10.1006/prep.2002.1626  0.48
2002 Han S, Moore RA, Viola RE. Synthesis and evaluation of alternative substrates for arginase. Bioorganic Chemistry. 30: 81-94. PMID 12020133 DOI: 10.1006/bioo.2001.1228  0.96
2002 James CL, Viola RE. Production and characterization of bifunctional enzymes. Substrate channeling in the aspartate pathway. Biochemistry. 41: 3726-31. PMID 11888290 DOI: 10.1021/bi0159074  0.48
2002 James CL, Viola RE. Production and characterization of bifunctional enzymes. Domain swapping to produce new bifunctional enzymes in the aspartate pathway. Biochemistry. 41: 3720-5. PMID 11888289 DOI: 10.1021/bi015909o  0.48
2002 Jude KM, Wright SK, Tu C, Silverman DN, Viola RE, Christianson DW. Crystal structure of F65A/Y131C-methylimidazole carbonic anhydrase V reveals architectural features of an engineered proton shuttle. Biochemistry. 41: 2485-91. PMID 11851394 DOI: 10.1021/bi015808q  0.48
2002 Blanco J, Viola RE. Purification, crystallization and preliminary X-ray analysis of aspartokinase III from Escherichia coli. Acta Crystallographica. Section D, Biological Crystallography. 58: 352-4. PMID 11807275  1
2001 Han S, Viola RE. A spectrophotometric assay of arginase. Analytical Biochemistry. 295: 117-9. PMID 11476554 DOI: 10.1006/abio.2001.5189  0.96
2001 Wright SK, Viola RE. Alteration of the specificity of malate dehydrogenase by chemical modulation of an active site arginine. The Journal of Biological Chemistry. 276: 31151-5. PMID 11389140 DOI: 10.1074/jbc.M100892200  0.48
1998 Scott ME, Viola RE. The use of fluoro- and deoxy-substrate analogs to examine binding specificity and catalysis in the enzymes of the sorbitol pathway Carbohydrate Research. 313: 247-253. PMID 10209867 DOI: 10.1016/S0008-6215(98)00266-3  0.48
1998 Wright SK, Viola RE. Evaluation of methods for the quantitation of cysteines in proteins. Analytical Biochemistry. 265: 8-14. PMID 9866701 DOI: 10.1006/abio.1998.2858  0.48
1996 Huo X, Viola RE. Substrate specificity and identification of functional groups of homoserine kinase from Escherichia colli Biochemistry. 35: 16180-16185. PMID 8973190  0.48
1996 Huo X, Viola RE. Functional group characterization of homoserine kinase from Escherichia coli Archives of Biochemistry and Biophysics. 330: 373-379. PMID 8660667 DOI: 10.1006/abbi.1996.0264  0.48
1995 Ouyang J, Viola RE. Use of structural comparisons to select mutagenic targets in aspartate-β-semialdehyde dehydrogenase Biochemistry®. 34: 6394-6399. PMID 7756269  0.48
1992 Angeles TS, Hunsley JR, Viola RE. Reversal of enzyme regiospecificity with alternative substrates for aspartokinase I from Escherichia coli Biochemistry. 31: 799-805. PMID 1731937  0.48
1989 Angeles TS, Smanik PA, Borders CL, Viola RE. Aspartokinase-homoserine dehydrogenase I from Escherichia coli: pH and chemical modification studies of the kinase activity. Biochemistry. 28: 8771-7. PMID 2557908  0.48
1983 Viola RE, Shaw RW, Ransom SC, Villafranca JJ. Solvent proton relaxation studies of cytochrome c oxidase solutions. Archives of Biochemistry and Biophysics. 220: 106-15. PMID 6299195 DOI: 10.1016/0003-9861(83)90392-2  0.48
1982 Viola RE, Cleland WW. Initial velocity analysis for terreactant mechanisms. Methods in Enzymology. 87: 353-66. PMID 7176920  1
1982 Viola RE, Raushel FM, Rendina AR, Cleland WW. Substrate synergism and the kinetic mechanism of yeast hexokinase. Biochemistry. 21: 1295-302. PMID 7041974  1
1980 Viola RE, Morrison JF, Cleland WW. Interaction of metal(III)-adenosine 5'-triphosphate complexes with yeast hexokinase. Biochemistry. 19: 3131-7. PMID 6996699  1
1980 Viola RE, Cleland WW. Aldehyde-induced adenosine triphosphatase activities of fructose 6-phosphate and fructose kinases. Biochemistry. 19: 1861-6. PMID 6246937  1
1979 Viola RE, Cook PF, Cleland WW. Stereoselective preparation of deuterated reduced nicotinamide adenine nucleotides and substrates by enzymatic synthesis. Analytical Biochemistry. 96: 334-40. PMID 224725  1
1978 Viola RE, Cleland WW. Use of pH studies to elucidate the chemical mechanism of yeast hexokinase. Biochemistry. 17: 4111-7. PMID 30473  1
1974 Villafranca JJ, Viola RE. Proton nuclear magnetic resonance studies of the manganese (II) binding site of concanavalin A. Effect of saccharides on the solvent relaxation rates. Archives of Biochemistry and Biophysics. 165: 51-9. PMID 4441085  1
1974 Villafranca JJ, Viola RE. The use of 13C spin lattice relaxation times to study the interaction of alpha-methyl-D-glucopyranoside with concanavalin A. Archives of Biochemistry and Biophysics. 160: 465-8. PMID 4364767  1
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