Jay Heinecke - Publications

Affiliations: 
Washington University, Saint Louis, St. Louis, MO 
Area:
Biochemistry

110 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Shao B, de Boer I, Tang C, Mayer PS, Zelnick L, Afkarian M, Heinecke JW, Himmelfarb J. A Cluster of Proteins Implicated in Kidney Disease Is Increased in High-Density Lipoprotein Isolated from Hemodialysis Subjects. Journal of Proteome Research. 14: 2792-806. PMID 26011469 DOI: 10.1021/acs.jproteome.5b00060  0.92
2015 Vaisar T, Tang C, Babenko I, Hutchins P, Wimberger J, Suffredini AF, Heinecke JW. Inflammatory remodeling of the HDL proteome impairs cholesterol efflux capacity. Journal of Lipid Research. 56: 1519-30. PMID 25995210 DOI: 10.1194/jlr.M059089  0.92
2015 Pamir N, Liu NC, Irwin A, Becker L, Peng Y, Ronsein GE, Bornfeldt KE, Duffield JS, Heinecke JW. Granulocyte/Macrophage Colony-stimulating Factor-dependent Dendritic Cells Restrain Lean Adipose Tissue Expansion. The Journal of Biological Chemistry. 290: 14656-67. PMID 25931125 DOI: 10.1074/jbc.M115.645820  0.92
2015 Heinecke JW. Small HDL promotes cholesterol efflux by the ABCA1 pathway in macrophages: implications for therapies targeted to HDL. Circulation Research. 116: 1101-3. PMID 25814677 DOI: 10.1161/CIRCRESAHA.115.306052  0.92
2015 Ronsein GE, Pamir N, von Haller PD, Kim DS, Oda MN, Jarvik GP, Vaisar T, Heinecke JW. Parallel reaction monitoring (PRM) and selected reaction monitoring (SRM) exhibit comparable linearity, dynamic range and precision for targeted quantitative HDL proteomics. Journal of Proteomics. 113: 388-99. PMID 25449833 DOI: 10.1016/j.jprot.2014.10.017  0.92
2014 Segrest JP, Jones MK, Shao B, Heinecke JW. An experimentally robust model of monomeric apolipoprotein A-I created from a chimera of two X-ray structures and molecular dynamics simulations. Biochemistry. 53: 7625-40. PMID 25423138 DOI: 10.1021/bi501111j  0.92
2014 Heinecke JW, Goldberg IJ. Myeloperoxidase: a therapeutic target for preventing insulin resistance and the metabolic sequelae of obesity? Diabetes. 63: 4001-3. PMID 25414015 DOI: 10.2337/db14-1273  0.92
2014 Lee JT, Pamir N, Liu NC, Kirk EA, Averill MM, Becker L, Larson I, Hagman DK, Foster-Schubert KE, van Yserloo B, Bornfeldt KE, LeBoeuf RC, Kratz M, Heinecke JW. Macrophage metalloelastase (MMP12) regulates adipose tissue expansion, insulin sensitivity, and expression of inducible nitric oxide synthase. Endocrinology. 155: 3409-20. PMID 24914938 DOI: 10.1210/en.2014-1037  0.92
2014 Smith CK, Vivekanandan-Giri A, Tang C, Knight JS, Mathew A, Padilla RL, Gillespie BW, Carmona-Rivera C, Liu X, Subramanian V, Hasni S, Thompson PR, Heinecke JW, Saran R, Pennathur S, et al. Neutrophil extracellular trap-derived enzymes oxidize high-density lipoprotein: an additional proatherogenic mechanism in systemic lupus erythematosus. Arthritis & Rheumatology (Hoboken, N.J.). 66: 2532-44. PMID 24838349 DOI: 10.1002/art.38703  0.92
2014 Shao B, Tang C, Sinha A, Mayer PS, Davenport GD, Brot N, Oda MN, Zhao XQ, Heinecke JW. Humans with atherosclerosis have impaired ABCA1 cholesterol efflux and enhanced high-density lipoprotein oxidation by myeloperoxidase. Circulation Research. 114: 1733-42. PMID 24647144 DOI: 10.1161/CIRCRESAHA.114.303454  0.92
2013 Toth PP, Barter PJ, Rosenson RS, Boden WE, Chapman MJ, Cuchel M, D'Agostino RB, Davidson MH, Davidson WS, Heinecke JW, Karas RH, Kontush A, Krauss RM, Miller M, Rader DJ. High-density lipoproteins: a consensus statement from the National Lipid Association. Journal of Clinical Lipidology. 7: 484-525. PMID 24079290 DOI: 10.1016/j.jacl.2013.08.001  0.92
2013 Rosenson RS, Brewer HB, Ansell B, Barter P, Chapman MJ, Heinecke JW, Kontush A, Tall AR, Webb NR. Translation of high-density lipoprotein function into clinical practice: current prospects and future challenges. Circulation. 128: 1256-67. PMID 24019446 DOI: 10.1161/CIRCULATIONAHA.113.000962  0.92
2013 Oda MN, Budamagunta MS, Geier EG, Chandradas SH, Shao B, Heinecke JW, Voss JC, Cavigiolio G. Conservation of apolipoprotein A-I's central domain structural elements upon lipid association on different high-density lipoprotein subclasses. Biochemistry. 52: 6766-78. PMID 23984834 DOI: 10.1021/bi4007012  0.92
2013 Kawakami T, Lichtnekert J, Thompson LJ, Karna P, Bouabe H, Hohl TM, Heinecke JW, Ziegler SF, Nelson PJ, Duffield JS. Resident renal mononuclear phagocytes comprise five discrete populations with distinct phenotypes and functions. Journal of Immunology (Baltimore, Md. : 1950). 191: 3358-72. PMID 23956422 DOI: 10.4049/jimmunol.1300342  0.92
2013 Campanholle G, Mittelsteadt K, Nakagawa S, Kobayashi A, Lin SL, Gharib SA, Heinecke JW, Hamerman JA, Altemeier WA, Duffield JS. TLR-2/TLR-4 TREM-1 signaling pathway is dispensable in inflammatory myeloid cells during sterile kidney injury. Plos One. 8: e68640. PMID 23844229 DOI: 10.1371/journal.pone.0068640  0.92
2013 Heinecke JW. HDL's protein cargo: friend or foe in cardioprotection? Circulation. 127: 868-9. PMID 23439444 DOI: 10.1161/CIRCULATIONAHA.112.000889  0.92
2013 Vivekanandan-Giri A, Slocum JL, Byun J, Tang C, Sands RL, Gillespie BW, Heinecke JW, Saran R, Kaplan MJ, Pennathur S. High density lipoprotein is targeted for oxidation by myeloperoxidase in rheumatoid arthritis. Annals of the Rheumatic Diseases. 72: 1725-31. PMID 23313808 DOI: 10.1136/annrheumdis-2012-202033  0.92
2012 Li J, Wang JJ, Peng Q, Chen C, Humphrey MB, Heinecke J, Zhang SX. Macrophage metalloelastase (MMP-12) deficiency mitigates retinal inflammation and pathological angiogenesis in ischemic retinopathy. Plos One. 7: e52699. PMID 23285156 DOI: 10.1371/journal.pone.0052699  0.92
2012 Suzuki M, Becker L, Pritchard DK, Gharib SA, Wijsman EM, Bammler TK, Beyer RP, Vaisar T, Oram JF, Heinecke JW. Cholesterol accumulation regulates expression of macrophage proteins implicated in proteolysis and complement activation. Arteriosclerosis, Thrombosis, and Vascular Biology. 32: 2910-8. PMID 23042816 DOI: 10.1161/ATVBAHA.112.300383  0.92
2012 Heinecke JW. The not-so-simple HDL story: A new era for quantifying HDL and cardiovascular risk? Nature Medicine. 18: 1346-7. PMID 22961165 DOI: 10.1038/nm.2930  0.92
2012 Rubinow KB, Vaisar T, Tang C, Matsumoto AM, Heinecke JW, Page ST. Testosterone replacement in hypogonadal men alters the HDL proteome but not HDL cholesterol efflux capacity. Journal of Lipid Research. 53: 1376-83. PMID 22504910 DOI: 10.1194/jlr.P026005  0.92
2012 Becker L, Liu NC, Averill MM, Yuan W, Pamir N, Peng Y, Irwin AD, Fu X, Bornfeldt KE, Heinecke JW. Unique proteomic signatures distinguish macrophages and dendritic cells. Plos One. 7: e33297. PMID 22428014 DOI: 10.1371/journal.pone.0033297  0.92
2012 Page ST, Krauss RM, Gross C, Ishida B, Heinecke JW, Tang C, Amory JK, Schaefer PM, Cox CJ, Kane J, Purnell JQ, Weinstein RL, Vaisar T. Impact of mifepristone, a glucocorticoid/progesterone antagonist, on HDL cholesterol, HDL particle concentration, and HDL function. The Journal of Clinical Endocrinology and Metabolism. 97: 1598-605. PMID 22399518 DOI: 10.1210/jc.2011-2813  0.92
2012 Francis GA, Heinecke JW. Advances in high density lipoprotein formation and metabolism: a tribute to John F. Oram (1945-2010). Biochimica Et Biophysica Acta. 1821: 343-4. PMID 22364764 DOI: 10.1016/j.bbalip.2012.02.006  0.92
2012 Kanter JE, Kramer F, Barnhart S, Averill MM, Vivekanandan-Giri A, Vickery T, Li LO, Becker L, Yuan W, Chait A, Braun KR, Potter-Perigo S, Sanda S, Wight TN, Pennathur S, ... ... Heinecke JW, et al. Diabetes promotes an inflammatory macrophage phenotype and atherosclerosis through acyl-CoA synthetase 1. Proceedings of the National Academy of Sciences of the United States of America. 109: E715-24. PMID 22308341 DOI: 10.1073/pnas.1111600109  0.92
2012 Rubinow KB, Tang C, Hoofnagle AN, Snyder CN, Amory JK, Heinecke JW, Page ST. Acute sex steroid withdrawal increases cholesterol efflux capacity and HDL-associated clusterin in men. Steroids. 77: 454-60. PMID 22266332 DOI: 10.1016/j.steroids.2012.01.002  0.92
2012 Shao B, Pennathur S, Heinecke JW. Myeloperoxidase targets apolipoprotein A-I, the major high density lipoprotein protein, for site-specific oxidation in human atherosclerotic lesions. The Journal of Biological Chemistry. 287: 6375-86. PMID 22219194 DOI: 10.1074/jbc.M111.337345  0.92
2012 Elsøe S, Ahnström J, Christoffersen C, Hoofnagle AN, Plomgaard P, Heinecke JW, Binder CJ, Björkbacka H, Dahlbäck B, Nielsen LB. Apolipoprotein M binds oxidized phospholipids and increases the antioxidant effect of HDL. Atherosclerosis. 221: 91-7. PMID 22204862 DOI: 10.1016/j.atherosclerosis.2011.11.031  0.92
2012 Gomez IG, Tang J, Wilson CL, Yan W, Heinecke JW, Harlan JM, Raines EW. Metalloproteinase-mediated Shedding of Integrin β2 promotes macrophage efflux from inflammatory sites. The Journal of Biological Chemistry. 287: 4581-9. PMID 22170060 DOI: 10.1074/jbc.M111.321182  0.92
2011 Shao B, Heinecke JW. Impact of HDL oxidation by the myeloperoxidase system on sterol efflux by the ABCA1 pathway. Journal of Proteomics. 74: 2289-99. PMID 21501700 DOI: 10.1016/j.jprot.2011.04.001  0.92
2011 Chiba T, Chang MY, Wang S, Wight TN, McMillen TS, Oram JF, Vaisar T, Heinecke JW, De Beer FC, De Beer MC, Chait A. Serum amyloid A facilitates the binding of high-density lipoprotein from mice injected with lipopolysaccharide to vascular proteoglycans. Arteriosclerosis, Thrombosis, and Vascular Biology. 31: 1326-32. PMID 21474830 DOI: 10.1161/ATVBAHA.111.226159  0.92
2011 Averill MM, Barnhart S, Becker L, Li X, Heinecke JW, Leboeuf RC, Hamerman JA, Sorg C, Kerkhoff C, Bornfeldt KE. S100A9 differentially modifies phenotypic states of neutrophils, macrophages, and dendritic cells: implications for atherosclerosis and adipose tissue inflammation. Circulation. 123: 1216-26. PMID 21382888 DOI: 10.1161/CIRCULATIONAHA.110.985523  0.92
2011 Herrero R, Kajikawa O, Matute-Bello G, Wang Y, Hagimoto N, Mongovin S, Wong V, Park DR, Brot N, Heinecke JW, Rosen H, Goodman RB, Fu X, Martin TR. The biological activity of FasL in human and mouse lungs is determined by the structure of its stalk region. The Journal of Clinical Investigation. 121: 1174-90. PMID 21285513 DOI: 10.1172/JCI43004  0.92
2010 Heinecke JW. The protein cargo of HDL: implications for vascular wall biology and therapeutics. Journal of Clinical Lipidology. 4: 371-5. PMID 20975842 DOI: 10.1016/j.jacl.2010.08.005  0.92
2010 Suzuki M, Pritchard DK, Becker L, Hoofnagle AN, Tanimura N, Bammler TK, Beyer RP, Bumgarner R, Vaisar T, de Beer MC, de Beer FC, Miyake K, Oram JF, Heinecke JW. High-density lipoprotein suppresses the type I interferon response, a family of potent antiviral immunoregulators, in macrophages challenged with lipopolysaccharide. Circulation. 122: 1919-27. PMID 20974999 DOI: 10.1161/CIRCULATIONAHA.110.961193  0.92
2010 Hoofnagle AN, Wu M, Gosmanova AK, Becker JO, Wijsman EM, Brunzell JD, Kahn SE, Knopp RH, Lyons TJ, Heinecke JW. Low clusterin levels in high-density lipoprotein associate with insulin resistance, obesity, and dyslipoproteinemia. Arteriosclerosis, Thrombosis, and Vascular Biology. 30: 2528-34. PMID 20847305 DOI: 10.1161/ATVBAHA.110.212894  0.92
2010 Cheung MC, Vaisar T, Han X, Heinecke JW, Albers JJ. Phospholipid transfer protein in human plasma associates with proteins linked to immunity and inflammation. Biochemistry. 49: 7314-22. PMID 20666409 DOI: 10.1021/bi100359f  0.92
2010 Cavigiolio G, Geier EG, Shao B, Heinecke JW, Oda MN. Exchange of apolipoprotein A-I between lipid-associated and lipid-free states: a potential target for oxidative generation of dysfunctional high density lipoproteins. The Journal of Biological Chemistry. 285: 18847-57. PMID 20385548 DOI: 10.1074/jbc.M109.098434  0.92
2010 Shao B, Pennathur S, Pagani I, Oda MN, Witztum JL, Oram JF, Heinecke JW. Modifying apolipoprotein A-I by malondialdehyde, but not by an array of other reactive carbonyls, blocks cholesterol efflux by the ABCA1 pathway. The Journal of Biological Chemistry. 285: 18473-84. PMID 20378541 DOI: 10.1074/jbc.M110.118182  0.92
2010 Crouch EC, Hirche TO, Shao B, Boxio R, Wartelle J, Benabid R, McDonald B, Heinecke J, Matalon S, Belaaouaj A. Myeloperoxidase-dependent inactivation of surfactant protein D in vitro and in vivo. The Journal of Biological Chemistry. 285: 16757-70. PMID 20228064 DOI: 10.1074/jbc.M109.097048  0.92
2010 Becker L, Gharib SA, Irwin AD, Wijsman E, Vaisar T, Oram JF, Heinecke JW. A macrophage sterol-responsive network linked to atherogenesis. Cell Metabolism. 11: 125-35. PMID 20142100 DOI: 10.1016/j.cmet.2010.01.003  0.92
2010 Shao B, Tang C, Heinecke JW, Oram JF. Oxidation of apolipoprotein A-I by myeloperoxidase impairs the initial interactions with ABCA1 required for signaling and cholesterol export. Journal of Lipid Research. 51: 1849-58. PMID 20064972 DOI: 10.1194/jlr.M004085  0.92
2010 Shao B, Oda MN, Oram JF, Heinecke JW. Myeloperoxidase: an oxidative pathway for generating dysfunctional high-density lipoprotein. Chemical Research in Toxicology. 23: 447-54. PMID 20043647 DOI: 10.1021/tx9003775  0.92
2009 Rosen H, Klebanoff SJ, Wang Y, Brot N, Heinecke JW, Fu X. Methionine oxidation contributes to bacterial killing by the myeloperoxidase system of neutrophils. Proceedings of the National Academy of Sciences of the United States of America. 106: 18686-91. PMID 19833874 DOI: 10.1073/pnas.0909464106  0.92
2009 Hoofnagle AN, Heinecke JW. Lipoproteomics: using mass spectrometry-based proteomics to explore the assembly, structure, and function of lipoproteins. Journal of Lipid Research. 50: 1967-75. PMID 19738003 DOI: 10.1194/jlr.R900015-JLR200  0.92
2009 Yuan W, Wang Y, Heinecke JW, Fu X. Hypochlorous acid converts the gamma-glutamyl group of glutathione disulfide to 5-hydroxybutyrolactam, a potential marker for neutrophil activation. The Journal of Biological Chemistry. 284: 26908-17. PMID 19584048 DOI: 10.1074/jbc.M109.005496  0.92
2009 Gharib SA, Vaisar T, Aitken ML, Park DR, Heinecke JW, Fu X. Mapping the lung proteome in cystic fibrosis. Journal of Proteome Research. 8: 3020-8. PMID 19354268 DOI: 10.1021/pr900093j  0.92
2009 Gross S, Gammon ST, Moss BL, Rauch D, Harding J, Heinecke JW, Ratner L, Piwnica-Worms D. Bioluminescence imaging of myeloperoxidase activity in vivo. Nature Medicine. 15: 455-61. PMID 19305414 DOI: 10.1038/nm.1886  0.92
2009 Chiba T, Han CY, Vaisar T, Shimokado K, Kargi A, Chen MH, Wang S, McDonald TO, O'Brien KD, Heinecke JW, Chait A. Serum amyloid A3 does not contribute to circulating SAA levels. Journal of Lipid Research. 50: 1353-62. PMID 19286646 DOI: 10.1194/jlr.M900089-JLR200  0.92
2009 Heinecke JW. A "new" thematic series: mass spectrometry-based proteomics of lipid biology. Journal of Lipid Research. 50: 777-80. PMID 19258282 DOI: 10.1194/jlr.E900002-JLR200  0.92
2009 Okamura DM, Pennathur S, Pasichnyk K, López-Guisa JM, Collins S, Febbraio M, Heinecke J, Eddy AA. CD36 regulates oxidative stress and inflammation in hypercholesterolemic CKD. Journal of the American Society of Nephrology : Jasn. 20: 495-505. PMID 19211715 DOI: 10.1681/ASN.2008010009  0.92
2009 Shao B, Heinecke JW. HDL, lipid peroxidation, and atherosclerosis. Journal of Lipid Research. 50: 599-601. PMID 19141435 DOI: 10.1194/jlr.E900001-JLR200  0.92
2009 Posey KA, Clegg DJ, Printz RL, Byun J, Morton GJ, Vivekanandan-Giri A, Pennathur S, Baskin DG, Heinecke JW, Woods SC, Schwartz MW, Niswender KD. Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet. American Journal of Physiology. Endocrinology and Metabolism. 296: E1003-12. PMID 19116375 DOI: 10.1152/ajpendo.90377.2008  0.92
2009 Vaisar T, Kassim SY, Gomez IG, Green PS, Hargarten S, Gough PJ, Parks WC, Wilson CL, Raines EW, Heinecke JW. MMP-9 sheds the beta2 integrin subunit (CD18) from macrophages. Molecular & Cellular Proteomics : McP. 8: 1044-60. PMID 19116209 DOI: 10.1074/mcp.M800449-MCP200  0.92
2009 Heinecke JW. The HDL proteome: a marker--and perhaps mediator--of coronary artery disease. Journal of Lipid Research. 50: S167-71. PMID 19060251 DOI: 10.1194/jlr.R800097-JLR200  0.92
2009 Wang XS, Shao B, Oda MN, Heinecke JW, Mahler S, Stocker R. A sensitive and specific ELISA detects methionine sulfoxide-containing apolipoprotein A-I in HDL. Journal of Lipid Research. 50: 586-94. PMID 18832772 DOI: 10.1194/jlr.D800042-JLR200  0.92
2008 Hoofnagle AN, Becker JO, Wener MH, Heinecke JW. Quantification of thyroglobulin, a low-abundance serum protein, by immunoaffinity peptide enrichment and tandem mass spectrometry. Clinical Chemistry. 54: 1796-804. PMID 18801935 DOI: 10.1373/clinchem.2008.109652  0.92
2008 Green PS, Vaisar T, Pennathur S, Kulstad JJ, Moore AB, Marcovina S, Brunzell J, Knopp RH, Zhao XQ, Heinecke JW. Combined statin and niacin therapy remodels the high-density lipoprotein proteome. Circulation. 118: 1259-67. PMID 18765395 DOI: 10.1161/CIRCULATIONAHA.108.770669  0.92
2008 Shao B, Cavigiolio G, Brot N, Oda MN, Heinecke JW. Methionine oxidation impairs reverse cholesterol transport by apolipoprotein A-I. Proceedings of the National Academy of Sciences of the United States of America. 105: 12224-9. PMID 18719109 DOI: 10.1073/pnas.0802025105  0.92
2008 Chang DW, Hayashi S, Gharib SA, Vaisar T, King ST, Tsuchiya M, Ruzinski JT, Park DR, Matute-Bello G, Wurfel MM, Bumgarner R, Heinecke JW, Martin TR. Proteomic and computational analysis of bronchoalveolar proteins during the course of the acute respiratory distress syndrome. American Journal of Respiratory and Critical Care Medicine. 178: 701-9. PMID 18658106 DOI: 10.1164/rccm.200712-1895OC  0.92
2008 Oram JF, Heinecke JW. When good cholesterol turns bad: the evolving saga of CETP inhibitors and clinical strategies to elevate high-density lipoprotein. Current Diabetes Reports. 8: 165-7. PMID 18625111 DOI: 10.1007/s11892-008-0028-8  0.92
2008 Xiao C, Watanabe T, Zhang Y, Trigatti B, Szeto L, Connelly PW, Marcovina S, Vaisar T, Heinecke JW, Lewis GF. Enhanced cellular uptake of remnant high-density lipoprotein particles: a mechanism for high-density lipoprotein lowering in insulin resistance and hypertriglyceridemia. Circulation Research. 103: 159-66. PMID 18556574 DOI: 10.1161/CIRCRESAHA.108.178756  0.92
2008 Shao B, Heinecke JW. Using tandem mass spectrometry to quantify site-specific chlorination and nitration of proteins: model system studies with high-density lipoprotein oxidized by myeloperoxidase. Methods in Enzymology. 440: 33-63. PMID 18423210 DOI: 10.1016/S0076-6879(07)00803-8  0.92
2008 Cavigiolio G, Shao B, Geier EG, Ren G, Heinecke JW, Oda MN. The interplay between size, morphology, stability, and functionality of high-density lipoprotein subclasses. Biochemistry. 47: 4770-9. PMID 18366184 DOI: 10.1021/bi7023354  0.92
2008 Kirk EA, Sagawa ZK, McDonald TO, O'Brien KD, Heinecke JW. Monocyte chemoattractant protein deficiency fails to restrain macrophage infiltration into adipose tissue [corrected]. Diabetes. 57: 1254-61. PMID 18268047 DOI: 10.2337/db07-1061  0.92
2008 Johansson F, Kramer F, Barnhart S, Kanter JE, Vaisar T, Merrill RD, Geng L, Oka K, Chan L, Chait A, Heinecke JW, Bornfeldt KE. Type 1 diabetes promotes disruption of advanced atherosclerotic lesions in LDL receptor-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. 105: 2082-7. PMID 18252823 DOI: 10.1073/pnas.0709958105  0.92
2008 Fu X, Gharib SA, Green PS, Aitken ML, Frazer DA, Park DR, Vaisar T, Heinecke JW. Spectral index for assessment of differential protein expression in shotgun proteomics. Journal of Proteome Research. 7: 845-54. PMID 18198819 DOI: 10.1021/pr070271+  0.92
2008 Fu X, Parks WC, Heinecke JW. Activation and silencing of matrix metalloproteinases. Seminars in Cell & Developmental Biology. 19: 2-13. PMID 17689277 DOI: 10.1016/j.semcdb.2007.06.005  0.92
2007 Oram JF, Heinecke JW. When good cholesterol turns bad: the evolving saga of CETP inhibitors and clinical strategies to elevate high-density lipoprotein. Current Atherosclerosis Reports. 9: 425-7. PMID 18377780 DOI: 10.1007/s11883-007-0055-y  0.92
2007 Heinecke JW. The role of myeloperoxidase in HDL oxidation and atherogenesis. Current Atherosclerosis Reports. 9: 249-51. PMID 18173946 DOI: 10.1007/s11883-007-0027-2  0.92
2007 Shepherd J, Hilderbrand SA, Waterman P, Heinecke JW, Weissleder R, Libby P. A fluorescent probe for the detection of myeloperoxidase activity in atherosclerosis-associated macrophages. Chemistry & Biology. 14: 1221-31. PMID 18022561 DOI: 10.1016/j.chembiol.2007.10.005  0.92
2007 Vaisar T, Shao B, Green PS, Oda MN, Oram JF, Heinecke JW. Myeloperoxidase and inflammatory proteins: pathways for generating dysfunctional high-density lipoprotein in humans. Current Atherosclerosis Reports. 9: 417-24. PMID 18001626 DOI: 10.1007/s11883-007-0054-z  0.92
2007 Wang Y, Rosen H, Madtes DK, Shao B, Martin TR, Heinecke JW, Fu X. Myeloperoxidase inactivates TIMP-1 by oxidizing its N-terminal cysteine residue: an oxidative mechanism for regulating proteolysis during inflammation. The Journal of Biological Chemistry. 282: 31826-34. PMID 17726014 DOI: 10.1074/jbc.M704894200  0.92
2007 Pennathur S, Heinecke JW. Oxidative stress and endothelial dysfunction in vascular disease. Current Diabetes Reports. 7: 257-64. PMID 17686400 DOI: 10.1007/s11892-007-0041-3  0.92
2007 Pennathur S, Heinecke JW. Mechanisms for oxidative stress in diabetic cardiovascular disease. Antioxidants & Redox Signaling. 9: 955-69. PMID 17508917 DOI: 10.1089/ars.2007.1595  0.92
2007 Vaisar T, Pennathur S, Green PS, Gharib SA, Hoofnagle AN, Cheung MC, Byun J, Vuletic S, Kassim S, Singh P, Chea H, Knopp RH, Brunzell J, Geary R, Chait A, ... ... Heinecke JW, et al. Shotgun proteomics implicates protease inhibition and complement activation in the antiinflammatory properties of HDL. The Journal of Clinical Investigation. 117: 746-56. PMID 17332893 DOI: 10.1172/JCI26206  0.92
2006 Shao B, Oda MN, Vaisar T, Oram JF, Heinecke JW. Pathways for oxidation of high-density lipoprotein in human cardiovascular disease. Current Opinion in Molecular Therapeutics. 8: 198-205. PMID 16774039  0.92
2006 Shao B, Oda MN, Oram JF, Heinecke JW. Myeloperoxidase: an inflammatory enzyme for generating dysfunctional high density lipoprotein. Current Opinion in Cardiology. 21: 322-8. PMID 16755201 DOI: 10.1097/01.hco.0000231402.87232.aa  0.92
2006 Heinecke JW. Chemical knockout of C-reactive protein in cardiovascular disease. Nature Chemical Biology. 2: 300-1. PMID 16710337 DOI: 10.1038/nchembio0606-300  0.92
2006 Gaut JP, Belaaouaj A, Byun J, Roberts LJ, Maeda N, Frei B, Heinecke JW. Vitamin C fails to protect amino acids and lipids from oxidation during acute inflammation. Free Radical Biology & Medicine. 40: 1494-501. PMID 16632110 DOI: 10.1016/j.freeradbiomed.2005.12.013  0.92
2006 Heinecke JW. Lipoprotein oxidation in cardiovascular disease: chief culprit or innocent bystander? The Journal of Experimental Medicine. 203: 813-6. PMID 16606677 DOI: 10.1084/jem.20060218  0.92
2006 Fu X, Wang Y, Kao J, Irwin A, d'Avignon A, Mecham RP, Parks WC, Heinecke JW. Specific sequence motifs direct the oxygenation and chlorination of tryptophan by myeloperoxidase. Biochemistry. 45: 3961-71. PMID 16548523 DOI: 10.1021/bi052339+  0.92
2006 Shao B, Oda MN, Bergt C, Fu X, Green PS, Brot N, Oram JF, Heinecke JW. Myeloperoxidase impairs ABCA1-dependent cholesterol efflux through methionine oxidation and site-specific tyrosine chlorination of apolipoprotein A-I. The Journal of Biological Chemistry. 281: 9001-4. PMID 16497665 DOI: 10.1074/jbc.C600011200  0.92
2006 Gurer-Orhan H, Ercal N, Mare S, Pennathur S, Orhan H, Heinecke JW. Misincorporation of free m-tyrosine into cellular proteins: a potential cytotoxic mechanism for oxidized amino acids. The Biochemical Journal. 395: 277-84. PMID 16363993 DOI: 10.1042/BJ20051964  0.92
2006 Takeshita J, Byun J, Nhan TQ, Pritchard DK, Pennathur S, Schwartz SM, Chait A, Heinecke JW. Myeloperoxidase generates 5-chlorouracil in human atherosclerotic tissue: a potential pathway for somatic mutagenesis by macrophages. The Journal of Biological Chemistry. 281: 3096-104. PMID 16326702 DOI: 10.1074/jbc.M509236200  0.92
2005 Vasilyev N, Williams T, Brennan ML, Unzek S, Zhou X, Heinecke JW, Spitz DR, Topol EJ, Hazen SL, Penn MS. Myeloperoxidase-generated oxidants modulate left ventricular remodeling but not infarct size after myocardial infarction. Circulation. 112: 2812-20. PMID 16267254 DOI: 10.1161/CIRCULATIONAHA.105.542340  0.92
2005 Oram JF, Heinecke JW. ATP-binding cassette transporter A1: a cell cholesterol exporter that protects against cardiovascular disease. Physiological Reviews. 85: 1343-72. PMID 16183915 DOI: 10.1152/physrev.00005.2005  0.92
2005 Shao B, Fu X, McDonald TO, Green PS, Uchida K, O'Brien KD, Oram JF, Heinecke JW. Acrolein impairs ATP binding cassette transporter A1-dependent cholesterol export from cells through site-specific modification of apolipoprotein A-I. The Journal of Biological Chemistry. 280: 36386-96. PMID 16126721 DOI: 10.1074/jbc.M508169200  0.92
2005 Shao B, O'brien KD, McDonald TO, Fu X, Oram JF, Uchida K, Heinecke JW. Acrolein modifies apolipoprotein A-I in the human artery wall. Annals of the New York Academy of Sciences. 1043: 396-403. PMID 16037261 DOI: 10.1196/annals.1333.046  0.92
2005 Choi DK, Pennathur S, Perier C, Tieu K, Teismann P, Wu DC, Jackson-Lewis V, Vila M, Vonsattel JP, Heinecke JW, Przedborski S. Ablation of the inflammatory enzyme myeloperoxidase mitigates features of Parkinson's disease in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 6594-600. PMID 16014720 DOI: 10.1523/JNEUROSCI.0970-05.2005  0.92
2005 Passarelli M, Tang C, McDonald TO, O'Brien KD, Gerrity RG, Heinecke JW, Oram JF. Advanced glycation end product precursors impair ABCA1-dependent cholesterol removal from cells. Diabetes. 54: 2198-205. PMID 15983222 DOI: 10.2337/diabetes.54.7.2198  0.92
2005 Kassim SY, Fu X, Liles WC, Shapiro SD, Parks WC, Heinecke JW. NADPH oxidase restrains the matrix metalloproteinase activity of macrophages. The Journal of Biological Chemistry. 280: 30201-5. PMID 15983040 DOI: 10.1074/jbc.M503292200  0.92
2005 Shao B, Belaaouaj A, Verlinde CL, Fu X, Heinecke JW. Methionine sulfoxide and proteolytic cleavage contribute to the inactivation of cathepsin G by hypochlorous acid: an oxidative mechanism for regulation of serine proteinases by myeloperoxidase. The Journal of Biological Chemistry. 280: 29311-21. PMID 15967795 DOI: 10.1074/jbc.M504040200  0.4
2005 McMillen TS, Heinecke JW, LeBoeuf RC. Expression of human myeloperoxidase by macrophages promotes atherosclerosis in mice. Circulation. 111: 2798-804. PMID 15911707 DOI: 10.1161/CIRCULATIONAHA.104.516278  0.92
2005 Pennathur S, Ido Y, Heller JI, Byun J, Danda R, Pergola P, Williamson JR, Heinecke JW. Reactive carbonyls and polyunsaturated fatty acids produce a hydroxyl radical-like species: a potential pathway for oxidative damage of retinal proteins in diabetes. The Journal of Biological Chemistry. 280: 22706-14. PMID 15855169 DOI: 10.1074/jbc.M500839200  0.92
2005 Vaisar T, Heinecke JW, Seymour JL, Turecek F. Copper-mediated intra-ligand oxygen transfer in gas-phase complexes with 3-nitrotyrosine. Journal of Mass Spectrometry : Jms. 40: 608-14. PMID 15724273 DOI: 10.1002/jms.829  0.92
2005 Hirche TO, Gaut JP, Heinecke JW, Belaaouaj A. Myeloperoxidase plays critical roles in killing Klebsiella pneumoniae and inactivating neutrophil elastase: effects on host defense. Journal of Immunology (Baltimore, Md. : 1950). 174: 1557-65. PMID 15661916  0.92
2004 Pennathur S, Bergt C, Shao B, Byun J, Kassim SY, Singh P, Green PS, McDonald TO, Brunzell J, Chait A, Oram JF, O'brien K, Geary RL, Heinecke JW. Human atherosclerotic intima and blood of patients with established coronary artery disease contain high density lipoprotein damaged by reactive nitrogen species. The Journal of Biological Chemistry. 279: 42977-83. PMID 15292228 DOI: 10.1074/jbc.M406762200  0.92
2004 Fu X, Kao JL, Bergt C, Kassim SY, Huq NP, d'Avignon A, Parks WC, Mecham RP, Heinecke JW. Oxidative cross-linking of tryptophan to glycine restrains matrix metalloproteinase activity: specific structural motifs control protein oxidation. The Journal of Biological Chemistry. 279: 6209-12. PMID 14670964 DOI: 10.1074/jbc.C300506200  0.92
2003 Fu X, Kassim SY, Parks WC, Heinecke JW. Hypochlorous acid generated by myeloperoxidase modifies adjacent tryptophan and glycine residues in the catalytic domain of matrix metalloproteinase-7 (matrilysin): an oxidative mechanism for restraining proteolytic activity during inflammation. The Journal of Biological Chemistry. 278: 28403-9. PMID 12759346 DOI: 10.1074/jbc.M304739200  0.92
2003 Henderson JP, Byun J, Takeshita J, Heinecke JW. Phagocytes produce 5-chlorouracil and 5-bromouracil, two mutagenic products of myeloperoxidase, in human inflammatory tissue. The Journal of Biological Chemistry. 278: 23522-8. PMID 12707270 DOI: 10.1074/jbc.M303928200  0.92
2002 Gaut JP, Byun J, Tran HD, Lauber WM, Carroll JA, Hotchkiss RS, Belaaouaj A, Heinecke JW. Myeloperoxidase produces nitrating oxidants in vivo. The Journal of Clinical Investigation. 109: 1311-9. PMID 12021246 DOI: 10.1172/JCI15021  0.92
2002 Gaut JP, Byun J, Tran HD, Heinecke JW. Artifact-free quantification of free 3-chlorotyrosine, 3-bromotyrosine, and 3-nitrotyrosine in human plasma by electron capture-negative chemical ionization gas chromatography mass spectrometry and liquid chromatography-electrospray ionization tandem mass spectrometry. Analytical Biochemistry. 300: 252-9. PMID 11779118 DOI: 10.1006/abio.2001.5469  0.92
2001 Gaut JP, Heinecke JW. Mechanisms for oxidizing low-density lipoprotein. Insights from patterns of oxidation products in the artery wall and from mouse models of atherosclerosis. Trends in Cardiovascular Medicine. 11: 103-12. PMID 11685998 DOI: 10.1016/S1050-1738(01)00101-3  0.92
2001 Gaut JP, Yeh GC, Tran HD, Byun J, Henderson JP, Richter GM, Brennan ML, Lusis AJ, Belaaouaj A, Hotchkiss RS, Heinecke JW. Neutrophils employ the myeloperoxidase system to generate antimicrobial brominating and chlorinating oxidants during sepsis. Proceedings of the National Academy of Sciences of the United States of America. 98: 11961-6. PMID 11593004 DOI: 10.1073/pnas.211190298  0.92
2001 Fu X, Kassim SY, Parks WC, Heinecke JW. Hypochlorous acid oxygenates the cysteine switch domain of pro-matrilysin (MMP-7). A mechanism for matrix metalloproteinase activation and atherosclerotic plaque rupture by myeloperoxidase. The Journal of Biological Chemistry. 276: 41279-87. PMID 11533038 DOI: 10.1074/jbc.M106958200  0.92
2000 Hazen SL, Gaut JP, Crowley JR, Hsu FF, Heinecke JW. Elevated levels of protein-bound p-hydroxyphenylacetaldehyde, an amino-acid-derived aldehyde generated by myeloperoxidase, are present in human fatty streaks, intermediate lesions and advanced atherosclerotic lesions. The Biochemical Journal. 352: 693-9. PMID 11104675 DOI: 10.1042/0264-6021:3520693  0.92
1999 Hazen SL, Hsu FF, Gaut JP, Crowley JR, Heinecke JW. Modification of proteins and lipids by myeloperoxidase. Methods in Enzymology. 300: 88-105. PMID 9919513 DOI: 10.1016/S0076-6879(99)00117-2  0.92
1998 McCormick ML, Gaut JP, Lin TS, Britigan BE, Buettner GR, Heinecke JW. Electron paramagnetic resonance detection of free tyrosyl radical generated by myeloperoxidase, lactoperoxidase, and horseradish peroxidase. The Journal of Biological Chemistry. 273: 32030-7. PMID 9822676 DOI: 10.1074/jbc.273.48.32030  0.92
1997 Hazen SL, Gaut JP, Hsu FF, Crowley JR, d'Avignon A, Heinecke JW. p-Hydroxyphenylacetaldehyde, the major product of L-tyrosine oxidation by the myeloperoxidase-H2O2-chloride system of phagocytes, covalently modifies epsilon-amino groups of protein lysine residues. The Journal of Biological Chemistry. 272: 16990-8. PMID 9202012 DOI: 10.1074/jbc.272.27.16990  0.92
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