☰

Jay Heinecke - Publications

Affiliations: 
Washington University, Saint Louis, St. Louis, MO 
Area:
Biochemistry
Tree Info Similar researchers PubMed Report error

81/288 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Henderson JP, Heinecke JW. Myeloperoxidase and eosinophil peroxidase: Phagocyte enzymes for halogenation in humans Handbook of Environmental Chemistry. 3: 201-214. DOI: 10.1007/b10448  0.318
2015 Rosenson RS, Brewer HB, Ansell BJ, Barter P, Chapman MJ, Heinecke JW, Kontush A, Tall AR, Webb NR. Dysfunctional HDL and atherosclerotic cardiovascular disease. Nature Reviews. Cardiology. PMID 26323267 DOI: 10.1038/nrcardio.2015.124  0.306
2014 Lee JT, Pamir N, Liu NC, Kirk EA, Averill MM, Becker L, Larson I, Hagman DK, Foster-Schubert KE, van Yserloo B, Bornfeldt KE, LeBoeuf RC, Kratz M, Heinecke JW. Macrophage metalloelastase (MMP12) regulates adipose tissue expansion, insulin sensitivity, and expression of inducible nitric oxide synthase. Endocrinology. 155: 3409-20. PMID 24914938 DOI: 10.1210/En.2014-1037  0.336
2014 Smith CK, Vivekanandan-Giri A, Tang C, Knight JS, Mathew A, Padilla RL, Gillespie BW, Carmona-Rivera C, Liu X, Subramanian V, Hasni S, Thompson PR, Heinecke JW, Saran R, Pennathur S, et al. Neutrophil extracellular trap-derived enzymes oxidize high-density lipoprotein: an additional proatherogenic mechanism in systemic lupus erythematosus. Arthritis & Rheumatology (Hoboken, N.J.). 66: 2532-44. PMID 24838349 DOI: 10.1002/Art.38703  0.327
2012 Li J, Wang JJ, Peng Q, Chen C, Humphrey MB, Heinecke J, Zhang SX. Macrophage metalloelastase (MMP-12) deficiency mitigates retinal inflammation and pathological angiogenesis in ischemic retinopathy. Plos One. 7: e52699. PMID 23285156 DOI: 10.1371/Journal.Pone.0052699  0.406
2012 Shao B, Pennathur S, Heinecke JW. Myeloperoxidase targets apolipoprotein A-I, the major high density lipoprotein protein, for site-specific oxidation in human atherosclerotic lesions. The Journal of Biological Chemistry. 287: 6375-86. PMID 22219194 DOI: 10.1074/jbc.M111.337345  0.331
2012 Elsøe S, Ahnström J, Christoffersen C, Hoofnagle AN, Plomgaard P, Heinecke JW, Binder CJ, Björkbacka H, Dahlbäck B, Nielsen LB. Apolipoprotein M binds oxidized phospholipids and increases the antioxidant effect of HDL. Atherosclerosis. 221: 91-7. PMID 22204862 DOI: 10.1016/J.Atherosclerosis.2011.11.031  0.31
2011 Shao B, Heinecke JW. Impact of HDL oxidation by the myeloperoxidase system on sterol efflux by the ABCA1 pathway. Journal of Proteomics. 74: 2289-99. PMID 21501700 DOI: 10.1016/j.jprot.2011.04.001  0.36
2011 Heinecke J. HDL and cardiovascular-disease risk--time for a new approach? The New England Journal of Medicine. 364: 170-1. PMID 21226584 DOI: 10.1056/Nejme1012520  0.331
2010 Shao B, Pennathur S, Pagani I, Oda MN, Witztum JL, Oram JF, Heinecke JW. Modifying apolipoprotein A-I by malondialdehyde, but not by an array of other reactive carbonyls, blocks cholesterol efflux by the ABCA1 pathway. The Journal of Biological Chemistry. 285: 18473-84. PMID 20378541 DOI: 10.1074/Jbc.M110.118182  0.315
2010 Crouch EC, Hirche TO, Shao B, Boxio R, Wartelle J, Benabid R, McDonald B, Heinecke J, Matalon S, Belaaouaj A. Myeloperoxidase-dependent inactivation of surfactant protein D in vitro and in vivo. The Journal of Biological Chemistry. 285: 16757-70. PMID 20228064 DOI: 10.1074/Jbc.M109.097048  0.336
2010 Shao B, Tang C, Heinecke JW, Oram JF. Oxidation of apolipoprotein A-I by myeloperoxidase impairs the initial interactions with ABCA1 required for signaling and cholesterol export. Journal of Lipid Research. 51: 1849-58. PMID 20064972 DOI: 10.1194/jlr.M004085  0.313
2010 Shao B, Oda MN, Oram JF, Heinecke JW. Myeloperoxidase: an oxidative pathway for generating dysfunctional high-density lipoprotein. Chemical Research in Toxicology. 23: 447-54. PMID 20043647 DOI: 10.1021/tx9003775  0.366
2009 Rosen H, Klebanoff SJ, Wang Y, Brot N, Heinecke JW, Fu X. Methionine oxidation contributes to bacterial killing by the myeloperoxidase system of neutrophils. Proceedings of the National Academy of Sciences of the United States of America. 106: 18686-91. PMID 19833874 DOI: 10.1073/pnas.0909464106  0.356
2009 Okamura DM, Pennathur S, Pasichnyk K, López-Guisa JM, Collins S, Febbraio M, Heinecke J, Eddy AA. CD36 regulates oxidative stress and inflammation in hypercholesterolemic CKD. Journal of the American Society of Nephrology : Jasn. 20: 495-505. PMID 19211715 DOI: 10.1681/Asn.2008010009  0.348
2009 Vaisar T, Kassim SY, Gomez IG, Green PS, Hargarten S, Gough PJ, Parks WC, Wilson CL, Raines EW, Heinecke JW. MMP-9 sheds the beta2 integrin subunit (CD18) from macrophages. Molecular & Cellular Proteomics : McP. 8: 1044-60. PMID 19116209 DOI: 10.1074/Mcp.M800449-Mcp200  0.742
2009 Heinecke JW. The HDL proteome: a marker--and perhaps mediator--of coronary artery disease. Journal of Lipid Research. 50: S167-71. PMID 19060251 DOI: 10.1194/jlr.R800097-JLR200  0.326
2009 Wang XS, Shao B, Oda MN, Heinecke JW, Mahler S, Stocker R. A sensitive and specific ELISA detects methionine sulfoxide-containing apolipoprotein A-I in HDL. Journal of Lipid Research. 50: 586-94. PMID 18832772 DOI: 10.1194/jlr.D800042-JLR200  0.359
2008 Shao B, Cavigiolio G, Brot N, Oda MN, Heinecke JW. Methionine oxidation impairs reverse cholesterol transport by apolipoprotein A-I. Proceedings of the National Academy of Sciences of the United States of America. 105: 12224-9. PMID 18719109 DOI: 10.1073/pnas.0802025105  0.369
2008 Shao B, Heinecke JW. Using tandem mass spectrometry to quantify site-specific chlorination and nitration of proteins: model system studies with high-density lipoprotein oxidized by myeloperoxidase. Methods in Enzymology. 440: 33-63. PMID 18423210 DOI: 10.1016/S0076-6879(07)00803-8  0.385
2008 Fu X, Parks WC, Heinecke JW. Activation and silencing of matrix metalloproteinases. Seminars in Cell & Developmental Biology. 19: 2-13. PMID 17689277 DOI: 10.1016/j.semcdb.2007.06.005  0.335
2007 Heinecke JW. The role of myeloperoxidase in HDL oxidation and atherogenesis. Current Atherosclerosis Reports. 9: 249-51. PMID 18173946 DOI: 10.1007/s11883-007-0027-2  0.316
2007 Vaisar T, Shao B, Green PS, Oda MN, Oram JF, Heinecke JW. Myeloperoxidase and inflammatory proteins: pathways for generating dysfunctional high-density lipoprotein in humans. Current Atherosclerosis Reports. 9: 417-24. PMID 18001626 DOI: 10.1007/s11883-007-0054-z  0.348
2007 Wang Y, Rosen H, Madtes DK, Shao B, Martin TR, Heinecke JW, Fu X. Myeloperoxidase inactivates TIMP-1 by oxidizing its N-terminal cysteine residue: an oxidative mechanism for regulating proteolysis during inflammation. The Journal of Biological Chemistry. 282: 31826-34. PMID 17726014 DOI: 10.1074/jbc.M704894200  0.413
2007 Vaisar T, Pennathur S, Green PS, Gharib SA, Hoofnagle AN, Cheung MC, Byun J, Vuletic S, Kassim S, Singh P, Chea H, Knopp RH, Brunzell J, Geary R, Chait A, ... ... Heinecke JW, et al. Shotgun proteomics implicates protease inhibition and complement activation in the antiinflammatory properties of HDL. The Journal of Clinical Investigation. 117: 746-56. PMID 17332893 DOI: 10.1172/Jci26206  0.74
2006 Shao B, Oda MN, Vaisar T, Oram JF, Heinecke JW. Pathways for oxidation of high-density lipoprotein in human cardiovascular disease. Current Opinion in Molecular Therapeutics. 8: 198-205. PMID 16774039  0.399
2006 Gaut JP, Belaaouaj A, Byun J, Roberts LJ, Maeda N, Frei B, Heinecke JW. Vitamin C fails to protect amino acids and lipids from oxidation during acute inflammation. Free Radical Biology & Medicine. 40: 1494-501. PMID 16632110 DOI: 10.1016/J.Freeradbiomed.2005.12.013  0.657
2006 Shao B, Oda MN, Bergt C, Fu X, Green PS, Brot N, Oram JF, Heinecke JW. Myeloperoxidase impairs ABCA1-dependent cholesterol efflux through methionine oxidation and site-specific tyrosine chlorination of apolipoprotein A-I. The Journal of Biological Chemistry. 281: 9001-4. PMID 16497665 DOI: 10.1074/jbc.C600011200  0.376
2006 Takeshita J, Byun J, Nhan TQ, Pritchard DK, Pennathur S, Schwartz SM, Chait A, Heinecke JW. Myeloperoxidase generates 5-chlorouracil in human atherosclerotic tissue: a potential pathway for somatic mutagenesis by macrophages. The Journal of Biological Chemistry. 281: 3096-104. PMID 16326702 DOI: 10.1074/Jbc.M509236200  0.57
2005 Shao B, O'brien KD, McDonald TO, Fu X, Oram JF, Uchida K, Heinecke JW. Acrolein modifies apolipoprotein A-I in the human artery wall. Annals of the New York Academy of Sciences. 1043: 396-403. PMID 16037261 DOI: 10.1196/annals.1333.046  0.304
2005 Kassim SY, Fu X, Liles WC, Shapiro SD, Parks WC, Heinecke JW. NADPH oxidase restrains the matrix metalloproteinase activity of macrophages. The Journal of Biological Chemistry. 280: 30201-5. PMID 15983040 DOI: 10.1074/Jbc.M503292200  0.762
2005 Shao B, Belaaouaj A, Verlinde CL, Fu X, Heinecke JW. Methionine sulfoxide and proteolytic cleavage contribute to the inactivation of cathepsin G by hypochlorous acid: an oxidative mechanism for regulation of serine proteinases by myeloperoxidase. The Journal of Biological Chemistry. 280: 29311-21. PMID 15967795 DOI: 10.1074/Jbc.M504040200  0.314
2005 McMillen TS, Heinecke JW, LeBoeuf RC. Expression of human myeloperoxidase by macrophages promotes atherosclerosis in mice. Circulation. 111: 2798-804. PMID 15911707 DOI: 10.1161/Circulationaha.104.516278  0.309
2005 Pennathur S, Ido Y, Heller JI, Byun J, Danda R, Pergola P, Williamson JR, Heinecke JW. Reactive carbonyls and polyunsaturated fatty acids produce a hydroxyl radical-like species: a potential pathway for oxidative damage of retinal proteins in diabetes. The Journal of Biological Chemistry. 280: 22706-14. PMID 15855169 DOI: 10.1074/jbc.M500839200  0.301
2005 Hirche TO, Gaut JP, Heinecke JW, Belaaouaj A. Myeloperoxidase plays critical roles in killing Klebsiella pneumoniae and inactivating neutrophil elastase: effects on host defense. Journal of Immunology (Baltimore, Md. : 1950). 174: 1557-65. PMID 15661916 DOI: 10.4049/Jimmunol.174.3.1557  0.644
2005 Shao B, Bergt C, Fu X, Green P, Voss JC, Oda MN, Oram JF, Heinecke JW. Tyrosine 192 in apolipoprotein A-I is the major site of nitration and chlorination by myeloperoxidase, but only chlorination markedly impairs ABCA1-dependent cholesterol transport. The Journal of Biological Chemistry. 280: 5983-93. PMID 15574409 DOI: 10.1074/Jbc.M411484200  0.332
2005 Aprikyan AA, Vaisar T, Makaryan V, Heinecke J. A Model of Severe Congenital Neutropenia Reveals Signaling Pathways Mediating Mutant Elastase-Triggered Agranulocytosis. Blood. 106: 3070-3070. DOI: 10.1182/Blood.V106.11.3070.3070  0.304
2005 Hirche T, Gaut J, Heinecke J, Wagner T, Belaaouaj A. Myeloperoxidase/Hypochlorsäure hemmt die enzymatische Aktivität der neutrophilen Serin-Proteinasen Pneumologie. 59. DOI: 10.1055/s-2005-864541  0.534
2004 Bergt C, Pennathur S, Fu X, Byun J, O'Brien K, McDonald TO, Singh P, Anantharamaiah GM, Chait A, Brunzell J, Geary RL, Oram JF, Heinecke JW. The myeloperoxidase product hypochlorous acid oxidizes HDL in the human artery wall and impairs ABCA1-dependent cholesterol transport. Proceedings of the National Academy of Sciences of the United States of America. 101: 13032-7. PMID 15326314 DOI: 10.1073/Pnas.0405292101  0.345
2004 Pennathur S, Bergt C, Shao B, Byun J, Kassim SY, Singh P, Green PS, McDonald TO, Brunzell J, Chait A, Oram JF, O'brien K, Geary RL, Heinecke JW. Human atherosclerotic intima and blood of patients with established coronary artery disease contain high density lipoprotein damaged by reactive nitrogen species. The Journal of Biological Chemistry. 279: 42977-83. PMID 15292228 DOI: 10.1074/Jbc.M406762200  0.747
2004 Fu X, Kao JL, Bergt C, Kassim SY, Huq NP, d'Avignon A, Parks WC, Mecham RP, Heinecke JW. Oxidative cross-linking of tryptophan to glycine restrains matrix metalloproteinase activity: specific structural motifs control protein oxidation. The Journal of Biological Chemistry. 279: 6209-12. PMID 14670964 DOI: 10.1074/Jbc.C300506200  0.774
2004 Bergt C, Fu X, Huq NP, Kao J, Heinecke JW. Lysine residues direct the chlorination of tyrosines in YXXK motifs of apolipoprotein A-I when hypochlorous acid oxidizes high density lipoprotein. The Journal of Biological Chemistry. 279: 7856-66. PMID 14660678 DOI: 10.1074/jbc.M309046200  0.354
2003 Anderson MM, Heinecke JW. Production of N(epsilon)-(carboxymethyl)lysine is impaired in mice deficient in NADPH oxidase: a role for phagocyte-derived oxidants in the formation of advanced glycation end products during inflammation. Diabetes. 52: 2137-43. PMID 12882933 DOI: 10.2337/diabetes.52.8.2137  0.332
2003 Fu X, Kassim SY, Parks WC, Heinecke JW. Hypochlorous acid generated by myeloperoxidase modifies adjacent tryptophan and glycine residues in the catalytic domain of matrix metalloproteinase-7 (matrilysin): an oxidative mechanism for restraining proteolytic activity during inflammation. The Journal of Biological Chemistry. 278: 28403-9. PMID 12759346 DOI: 10.1074/Jbc.M304739200  0.776
2003 Henderson JP, Byun J, Takeshita J, Heinecke JW. Phagocytes produce 5-chlorouracil and 5-bromouracil, two mutagenic products of myeloperoxidase, in human inflammatory tissue. The Journal of Biological Chemistry. 278: 23522-8. PMID 12707270 DOI: 10.1074/Jbc.M303928200  0.549
2003 Heinecke JW. Oxidative stress: new approaches to diagnosis and prognosis in atherosclerosis. The American Journal of Cardiology. 91: 12A-16A. PMID 12645639 DOI: 10.1016/S0002-9149(02)03145-4  0.373
2002 Heinecke JW. Tyrosyl radical production by myeloperoxidase: a phagocyte pathway for lipid peroxidation and dityrosine cross-linking of proteins. Toxicology. 177: 11-22. PMID 12126792 DOI: 10.1016/S0300-483X(02)00192-0  0.304
2002 Heinecke JW. Oxidized amino acids: culprits in human atherosclerosis and indicators of oxidative stress. Free Radical Biology & Medicine. 32: 1090-101. PMID 12031894 DOI: 10.1016/S0891-5849(02)00792-X  0.371
2002 Gaut JP, Byun J, Tran HD, Lauber WM, Carroll JA, Hotchkiss RS, Belaaouaj A, Heinecke JW. Myeloperoxidase produces nitrating oxidants in vivo. The Journal of Clinical Investigation. 109: 1311-9. PMID 12021246 DOI: 10.1172/Jci15021  0.623
2002 Fu X, Mueller DM, Heinecke JW. Generation of intramolecular and intermolecular sulfenamides, sulfinamides, and sulfonamides by hypochlorous acid: a potential pathway for oxidative cross-linking of low-density lipoprotein by myeloperoxidase. Biochemistry. 41: 1293-301. PMID 11802729 DOI: 10.1021/bi015777z  0.307
2002 Gaut JP, Byun J, Tran HD, Heinecke JW. Artifact-free quantification of free 3-chlorotyrosine, 3-bromotyrosine, and 3-nitrotyrosine in human plasma by electron capture-negative chemical ionization gas chromatography mass spectrometry and liquid chromatography-electrospray ionization tandem mass spectrometry. Analytical Biochemistry. 300: 252-9. PMID 11779118 DOI: 10.1006/Abio.2001.5469  0.577
2001 Gaut JP, Heinecke JW. Mechanisms for oxidizing low-density lipoprotein. Insights from patterns of oxidation products in the artery wall and from mouse models of atherosclerosis. Trends in Cardiovascular Medicine. 11: 103-12. PMID 11685998 DOI: 10.1016/S1050-1738(01)00101-3  0.649
2001 Gaut JP, Yeh GC, Tran HD, Byun J, Henderson JP, Richter GM, Brennan ML, Lusis AJ, Belaaouaj A, Hotchkiss RS, Heinecke JW. Neutrophils employ the myeloperoxidase system to generate antimicrobial brominating and chlorinating oxidants during sepsis. Proceedings of the National Academy of Sciences of the United States of America. 98: 11961-6. PMID 11593004 DOI: 10.1073/Pnas.211190298  0.629
2001 Fu X, Kassim SY, Parks WC, Heinecke JW. Hypochlorous acid oxygenates the cysteine switch domain of pro-matrilysin (MMP-7). A mechanism for matrix metalloproteinase activation and atherosclerotic plaque rupture by myeloperoxidase. The Journal of Biological Chemistry. 276: 41279-87. PMID 11533038 DOI: 10.1074/Jbc.M106958200  0.771
2001 Bergt C, Marsche G, Panzenboeck U, Heinecke JW, Malle E, Sattler W. Human neutrophils employ the myeloperoxidase/hydrogen peroxide/chloride system to oxidatively damage apolipoprotein A-I. European Journal of Biochemistry / Febs. 268: 3523-31. PMID 11422382 DOI: 10.1046/j.1432-1327.2001.02253.x  0.412
2001 Henderson JP, Byun J, Mueller DM, Heinecke JW. The eosinophil peroxidase-hydrogen peroxide-bromide system of human eosinophils generates 5-bromouracil, a mutagenic thymine analogue. Biochemistry. 40: 2052-9. PMID 11329272 DOI: 10.1021/Bi002015F  0.302
2001 Brennan ML, Anderson MM, Shih DM, Qu XD, Wang X, Mehta AC, Lim LL, Shi W, Hazen SL, Jacob JS, Crowley JR, Heinecke JW, Lusis AJ. Increased atherosclerosis in myeloperoxidase-deficient mice. The Journal of Clinical Investigation. 107: 419-30. PMID 11181641 DOI: 10.1172/Jci8797  0.339
2000 Hazen SL, Gaut JP, Crowley JR, Hsu FF, Heinecke JW. Elevated levels of protein-bound p-hydroxyphenylacetaldehyde, an amino-acid-derived aldehyde generated by myeloperoxidase, are present in human fatty streaks, intermediate lesions and advanced atherosclerotic lesions. The Biochemical Journal. 352: 693-9. PMID 11104675 DOI: 10.1042/0264-6021:3520693  0.651
2000 Kirk EA, Dinauer MC, Rosen H, Chait A, Heinecke JW, LeBoeuf RC. Impaired superoxide production due to a deficiency in phagocyte NADPH oxidase fails to inhibit atherosclerosis in mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 20: 1529-35. PMID 10845868 DOI: 10.1161/01.Atv.20.6.1529  0.329
2000 Heller JI, Crowley JR, Hazen SL, Salvay DM, Wagner P, Pennathur S, Heinecke JW. p-hydroxyphenylacetaldehyde, an aldehyde generated by myeloperoxidase, modifies phospholipid amino groups of low density lipoprotein in human atherosclerotic intima. The Journal of Biological Chemistry. 275: 9957-62. PMID 10744670 DOI: 10.1074/Jbc.275.14.9957  0.386
1999 Anderson MM, Requena JR, Crowley JR, Thorpe SR, Heinecke JW. The myeloperoxidase system of human phagocytes generates Nepsilon-(carboxymethyl)lysine on proteins: a mechanism for producing advanced glycation end products at sites of inflammation. The Journal of Clinical Investigation. 104: 103-13. PMID 10393704 DOI: 10.1172/JCI3042  0.308
1999 Heinecke JW. Mass spectrometric quantification of amino acid oxidation products in proteins: insights into pathways that promote LDL oxidation in the human artery wall. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 13: 1113-20. PMID 10385603 DOI: 10.1096/fasebj.13.10.1113  0.338
1999 Whitman SC, Hazen SL, Miller DB, Hegele RA, Heinecke JW, Huff MW. Modification of type III VLDL, their remnants, and VLDL from ApoE-knockout mice by p-hydroxyphenylacetaldehyde, a product of myeloperoxidase activity, causes marked cholesteryl ester accumulation in macrophages. Arteriosclerosis, Thrombosis, and Vascular Biology. 19: 1238-49. PMID 10323775 DOI: 10.1161/01.Atv.19.5.1238  0.353
1999 Byun J, Henderson JP, Mueller DM, Heinecke JW. 8-Nitro-2'-deoxyguanosine, a specific marker of oxidation by reactive nitrogen species, is generated by the myeloperoxidase-hydrogen peroxide-nitrite system of activated human phagocytes. Biochemistry. 38: 2590-600. PMID 10029554 DOI: 10.1021/bi9822980  0.334
1999 Heinecke JW, Hsu FF, Crowley JR, Hazen SL, Leeuwenburgh C, Mueller DM, Rasmussen JE, Turk J. Detecting oxidative modification of biomolecules with isotope dilution mass spectrometry: sensitive and quantitative assays for oxidized amino acids in proteins and tissues. Methods in Enzymology. 300: 124-44. PMID 9919517 DOI: 10.1016/S0076-6879(99)00121-4  0.32
1999 Hazen SL, Hsu FF, Gaut JP, Crowley JR, Heinecke JW. Modification of proteins and lipids by myeloperoxidase. Methods in Enzymology. 300: 88-105. PMID 9919513 DOI: 10.1016/S0076-6879(99)00117-2  0.671
1998 McCormick ML, Gaut JP, Lin TS, Britigan BE, Buettner GR, Heinecke JW. Electron paramagnetic resonance detection of free tyrosyl radical generated by myeloperoxidase, lactoperoxidase, and horseradish peroxidase. The Journal of Biological Chemistry. 273: 32030-7. PMID 9822676 DOI: 10.1074/Jbc.273.48.32030  0.602
1998 Crowley JR, Yarasheski K, Leeuwenburgh C, Turk J, Heinecke JW. Isotope dilution mass spectrometric quantification of 3-nitrotyrosine in proteins and tissues is facilitated by reduction to 3-aminotyrosine. Analytical Biochemistry. 259: 127-35. PMID 9606153 DOI: 10.1006/Abio.1998.2635  0.305
1997 Hazen SL, Crowley JR, Mueller DM, Heinecke JW. Mass spectrometric quantification of 3-chlorotyrosine in human tissues with attomole sensitivity: a sensitive and specific marker for myeloperoxidase-catalyzed chlorination at sites of inflammation. Free Radical Biology & Medicine. 23: 909-16. PMID 9378370 DOI: 10.1016/S0891-5849(97)00084-1  0.325
1997 Hazen SL, Gaut JP, Hsu FF, Crowley JR, d'Avignon A, Heinecke JW. p-Hydroxyphenylacetaldehyde, the major product of L-tyrosine oxidation by the myeloperoxidase-H2O2-chloride system of phagocytes, covalently modifies epsilon-amino groups of protein lysine residues. The Journal of Biological Chemistry. 272: 16990-8. PMID 9202012 DOI: 10.1074/Jbc.272.27.16990  0.631
1997 Hazen SL, Heinecke JW. 3-Chlorotyrosine, a specific marker of myeloperoxidase-catalyzed oxidation, is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima. The Journal of Clinical Investigation. 99: 2075-81. PMID 9151778 DOI: 10.1172/Jci119379  0.397
1997 Leeuwenburgh C, Hardy MM, Hazen SL, Wagner P, Oh-ishi S, Steinbrecher UP, Heinecke JW. Reactive nitrogen intermediates promote low density lipoprotein oxidation in human atherosclerotic intima. The Journal of Biological Chemistry. 272: 1433-6. PMID 8999808 DOI: 10.1074/Jbc.272.3.1433  0.388
1996 Hazen SL, Hsu FF, Duffin K, Heinecke JW. Molecular chlorine generated by the myeloperoxidase-hydrogen peroxide-chloride system of phagocytes converts low density lipoprotein cholesterol into a family of chlorinated sterols. The Journal of Biological Chemistry. 271: 23080-8. PMID 8798498 DOI: 10.1074/Jbc.271.38.23080  0.306
1996 Berliner JA, Heinecke JW. The role of oxidized lipoproteins in atherogenesis. Free Radical Biology & Medicine. 20: 707-27. PMID 8721615 DOI: 10.1016/0891-5849(95)02173-6  0.365
1996 Jacob JS, Cistola DP, Hsu FF, Muzaffar S, Mueller DM, Hazen SL, Heinecke JW. Human phagocytes employ the myeloperoxidase-hydrogen peroxide system to synthesize dityrosine, trityrosine, pulcherosine, and isodityrosine by a tyrosyl radical-dependent pathway. The Journal of Biological Chemistry. 271: 19950-6. PMID 8702710 DOI: 10.1074/Jbc.271.33.19950  0.351
1994 Heinecke JW. Cellular mechanisms for the oxidative modification of lipoproteins: implications for atherogenesis. Coronary Artery Disease. 5: 205-10. PMID 8199734 DOI: 10.1097/00019501-199403000-00004  0.31
1994 Daugherty A, Dunn JL, Rateri DL, Heinecke JW. Myeloperoxidase, a catalyst for lipoprotein oxidation, is expressed in human atherosclerotic lesions. The Journal of Clinical Investigation. 94: 437-44. PMID 8040285 DOI: 10.1172/JCI117342  0.347
1994 Chait A, Heinecke JW. Lipoprotein modification: cellular mechanisms. Current Opinion in Lipidology. 5: 365-70. PMID 7858911 DOI: 10.1097/00041433-199410000-00008  0.325
1993 Heinecke JW, Li W, Francis GA, Goldstein JA. Tyrosyl radical generated by myeloperoxidase catalyzes the oxidative cross-linking of proteins. The Journal of Clinical Investigation. 91: 2866-72. PMID 8390491 DOI: 10.1172/JCI116531  0.315
1993 Francis GA, Mendez AJ, Bierman EL, Heinecke JW. Oxidative tyrosylation of high density lipoprotein by peroxidase enhances cholesterol removal from cultured fibroblasts and macrophage foam cells. Proceedings of the National Academy of Sciences of the United States of America. 90: 6631-5. PMID 8341680 DOI: 10.1073/Pnas.90.14.6631  0.317
1987 Hiramatsu K, Rosen H, Heinecke JW, Wolfbauer G, Chait A. Superoxide initiates oxidation of low density lipoprotein by human monocytes. Arteriosclerosis (Dallas, Tex.). 7: 55-60. PMID 3028347 DOI: 10.1161/01.ATV.7.1.55  0.327
Low-probability matches (unlikely to be authored by this person)
1996 Hazen SL, Hsu FF, Mueller DM, Crowley JR, Heinecke JW. Human neutrophils employ chlorine gas as an oxidant during phagocytosis. The Journal of Clinical Investigation. 98: 1283-9. PMID 8823292 DOI: 10.1172/Jci118914  0.3
1994 Heinecke JW, Li W, Mueller DM, Bohrer A, Turk J. Cholesterol chlorohydrin synthesis by the myeloperoxidase-hydrogen peroxide-chloride system: potential markers for lipoproteins oxidatively damaged by phagocytes. Biochemistry. 33: 10127-36. PMID 8060981 DOI: 10.1021/bi00199a041  0.298
1998 Heinecke JW. Oxidants and antioxidants in the pathogenesis of atherosclerosis: implications for the oxidized low density lipoprotein hypothesis. Atherosclerosis. 141: 1-15. PMID 9863534 DOI: 10.1016/S0021-9150(98)00173-7  0.297
2002 Rosen H, Crowley JR, Heinecke JW. Human neutrophils use the myeloperoxidase-hydrogen peroxide-chloride system to chlorinate but not nitrate bacterial proteins during phagocytosis. The Journal of Biological Chemistry. 277: 30463-8. PMID 12060654 DOI: 10.1074/jbc.M202331200  0.297
2003 Bergt C, Oram JF, Heinecke JW. Oxidized HDL: the paradox-idation of lipoproteins. Arteriosclerosis, Thrombosis, and Vascular Biology. 23: 1488-90. PMID 12972461 DOI: 10.1161/01.ATV.0000090570.99836.9C  0.296
1997 Tribble DL, Gong EL, Leeuwenburgh C, Heinecke JW, Carlson EL, Verstuyft JG, Epstein CJ. Fatty streak formation in fat-fed mice expressing human copper-zinc superoxide dismutase. Arteriosclerosis, Thrombosis, and Vascular Biology. 17: 1734-40. PMID 9327771 DOI: 10.1161/01.Atv.17.9.1734  0.296
2001 Himmelfarb J, McMenamin ME, Loseto G, Heinecke JW. Myeloperoxidase-catalyzed 3-chlorotyrosine formation in dialysis patients. Free Radical Biology & Medicine. 31: 1163-9. PMID 11705694 DOI: 10.1016/S0891-5849(01)00697-9  0.295
2003 Yeh GC, Henderson JP, Byun J, André d'Avignon D, Heinecke JW. 8-Nitroxanthine, a product of myeloperoxidase, peroxynitrite, and activated human neutrophils, enhances generation of superoxide by xanthine oxidase. Archives of Biochemistry and Biophysics. 418: 1-12. PMID 13679077 DOI: 10.1016/S0003-9861(03)00256-X  0.294
2009 Yuan W, Wang Y, Heinecke JW, Fu X. Hypochlorous acid converts the gamma-glutamyl group of glutathione disulfide to 5-hydroxybutyrolactam, a potential marker for neutrophil activation. The Journal of Biological Chemistry. 284: 26908-17. PMID 19584048 DOI: 10.1074/jbc.M109.005496  0.292
2001 Pennathur S, Wagner JD, Leeuwenburgh C, Litwak KN, Heinecke JW. A hydroxyl radical-like species oxidizes cynomolgus monkey artery wall proteins in early diabetic vascular disease. The Journal of Clinical Investigation. 107: 853-60. PMID 11285304 DOI: 10.1172/Jci11194  0.292
1994 Kawamura M, Heinecke JW, Chait A. Pathophysiological concentrations of glucose promote oxidative modification of low density lipoprotein by a superoxide-dependent pathway. The Journal of Clinical Investigation. 94: 771-8. PMID 8040332 DOI: 10.1172/JCI117396  0.29
2004 Lamharzi N, Renard CB, Kramer F, Pennathur S, Heinecke JW, Chait A, Bornfeldt KE. Hyperlipidemia in concert with hyperglycemia stimulates the proliferation of macrophages in atherosclerotic lesions: potential role of glucose-oxidized LDL. Diabetes. 53: 3217-25. PMID 15561953 DOI: 10.2337/diabetes.53.12.3217  0.288
2004 Aprikyan AA, Vaisar T, Makaryan V, Heinecke J. Cellular Model of Severe Congenital Neutropenia Reveals the Molecular Mechanism of Mutant Elastase-Mediated Agranulocytosis. Blood. 104: 1453-1453. DOI: 10.1182/Blood.V104.11.1453.1453  0.287
2006 Heinecke JW. Lipoprotein oxidation in cardiovascular disease: chief culprit or innocent bystander? The Journal of Experimental Medicine. 203: 813-6. PMID 16606677 DOI: 10.1084/jem.20060218  0.287
1999 Byun J, Mueller DM, Fabjan JS, Heinecke JW. Nitrogen dioxide radical generated by the myeloperoxidase-hydrogen peroxide-nitrite system promotes lipid peroxidation of low density lipoprotein. Febs Letters. 455: 243-6. PMID 10437781 DOI: 10.1016/S0014-5793(99)00893-5  0.283
2005 Chait A, Han CY, Oram JF, Heinecke JW. Thematic review series: The immune system and atherogenesis. Lipoprotein-associated inflammatory proteins: markers or mediators of cardiovascular disease? Journal of Lipid Research. 46: 389-403. PMID 15722558 DOI: 10.1194/jlr.R400017-JLR200  0.282
1997 Heinecke JW. Mechanisms of oxidative damage of low density lipoprotein in human atherosclerosis. Current Opinion in Lipidology. 8: 268-74. PMID 9335950 DOI: 10.1097/00041433-199710000-00005  0.276
1999 Hazen SL, Heller J, Hsu FF, d'Avignon A, Heinecke JW. Synthesis, isolation, and characterization of the adduct formed in the reaction of p-hydroxyphenylacetaldehyde with the amino headgroup of phosphatidylethanolamine and phosphatidylserine. Chemical Research in Toxicology. 12: 19-27. PMID 9894014 DOI: 10.1021/Tx980147S  0.275
2005 Shao B, Fu X, McDonald TO, Green PS, Uchida K, O'Brien KD, Oram JF, Heinecke JW. Acrolein impairs ATP binding cassette transporter A1-dependent cholesterol export from cells through site-specific modification of apolipoprotein A-I. The Journal of Biological Chemistry. 280: 36386-96. PMID 16126721 DOI: 10.1074/jbc.M508169200  0.274
2017 Pamir N, Hutchins PM, Ronsein GE, Wei H, Tang C, Das R, Vaisar T, Plow E, Schuster V, Reardon CA, Weinberg R, Dichek DA, Marcovina S, Getz GS, Heinecke JW. Plasminogen promotes cholesterol efflux by the ABCA1 pathway. Jci Insight. 2. PMID 28768900 DOI: 10.1172/Jci.Insight.92176  0.272
2005 Kadiiska MB, Gladen BC, Baird DD, Germolec D, Graham LB, Parker CE, Nyska A, Wachsman JT, Ames BN, Basu S, Brot N, Fitzgerald GA, Floyd RA, George M, Heinecke JW, et al. Biomarkers of oxidative stress study II: are oxidation products of lipids, proteins, and DNA markers of CCl4 poisoning? Free Radical Biology & Medicine. 38: 698-710. PMID 15721980 DOI: 10.1016/J.Freeradbiomed.2004.09.017  0.272
2005 Oram JF, Heinecke JW. ATP-binding cassette transporter A1: a cell cholesterol exporter that protects against cardiovascular disease. Physiological Reviews. 85: 1343-72. PMID 16183915 DOI: 10.1152/physrev.00005.2005  0.268
2001 Heinecke JW. Is the emperor wearing clothes? Clinical trials of vitamin E and the LDL oxidation hypothesis. Arteriosclerosis, Thrombosis, and Vascular Biology. 21: 1261-4. PMID 11498450 DOI: 10.1161/hq0801.095084  0.266
1999 Henderson JP, Byun J, Heinecke JW. Molecular chlorine generated by the myeloperoxidase-hydrogen peroxide-chloride system of phagocytes produces 5-chlorocytosine in bacterial RNA. The Journal of Biological Chemistry. 274: 33440-8. PMID 10559226 DOI: 10.1074/Jbc.274.47.33440  0.266
1996 Hazen SL, Hsu FF, Heinecke JW. p-Hydroxyphenylacetaldehyde is the major product of L-tyrosine oxidation by activated human phagocytes. A chloride-dependent mechanism for the conversion of free amino acids into reactive aldehydes by myeloperoxidase. The Journal of Biological Chemistry. 271: 1861-7. PMID 8567631 DOI: 10.1074/Jbc.271.4.1861  0.265
2001 Sugiyama S, Okada Y, Sukhova GK, Virmani R, Heinecke JW, Libby P. Macrophage myeloperoxidase regulation by granulocyte macrophage colony-stimulating factor in human atherosclerosis and implications in acute coronary syndromes. The American Journal of Pathology. 158: 879-91. PMID 11238037 DOI: 10.1016/S0002-9440(10)64036-9  0.265
1998 Hazen SL, Hsu FF, d'Avignon A, Heinecke JW. Human neutrophils employ myeloperoxidase to convert alpha-amino acids to a battery of reactive aldehydes: a pathway for aldehyde generation at sites of inflammation. Biochemistry. 37: 6864-73. PMID 9578573 DOI: 10.1021/Bi972449J  0.263
1997 Heinecke JW. Pathways for oxidation of low density lipoprotein by myeloperoxidase: tyrosyl radical, reactive aldehydes, hypochlorous acid and molecular chlorine. Biofactors (Oxford, England). 6: 145-55. PMID 9259996 DOI: 10.1002/biof.5520060208  0.263
2012 Suzuki M, Becker L, Pritchard DK, Gharib SA, Wijsman EM, Bammler TK, Beyer RP, Vaisar T, Oram JF, Heinecke JW. Cholesterol accumulation regulates expression of macrophage proteins implicated in proteolysis and complement activation. Arteriosclerosis, Thrombosis, and Vascular Biology. 32: 2910-8. PMID 23042816 DOI: 10.1161/Atvbaha.112.300383  0.262
2017 Wu X, Tang C, Zhao X, Neradilek M, Isquith D, Chen M, Xu Y, Li H, Heinecke J. Differences in Cholesterol Efflux Capacity Mediated by the ABCA1, ABCG1 and SR-B1 Pathways in Patients With Acute Coronary Syndrome and Stable Coronar Journal of Clinical Lipidology. 11: 775-776. DOI: 10.1016/J.Jacl.2017.04.010  0.26
1995 Shaish A, Daugherty A, O'Sullivan F, Schonfeld G, Heinecke JW. Beta-carotene inhibits atherosclerosis in hypercholesterolemic rabbits. The Journal of Clinical Investigation. 96: 2075-82. PMID 7560102 DOI: 10.1172/JCI118256  0.26
2014 Shao B, Tang C, Sinha A, Mayer PS, Davenport GD, Brot N, Oda MN, Zhao XQ, Heinecke JW. Humans with atherosclerosis have impaired ABCA1 cholesterol efflux and enhanced high-density lipoprotein oxidation by myeloperoxidase. Circulation Research. 114: 1733-42. PMID 24647144 DOI: 10.1161/CIRCRESAHA.114.303454  0.254
2011 Herrero R, Kajikawa O, Matute-Bello G, Wang Y, Hagimoto N, Mongovin S, Wong V, Park DR, Brot N, Heinecke JW, Rosen H, Goodman RB, Fu X, Martin TR. The biological activity of FasL in human and mouse lungs is determined by the structure of its stalk region. The Journal of Clinical Investigation. 121: 1174-90. PMID 21285513 DOI: 10.1172/JCI43004  0.254
2009 Hoofnagle AN, Heinecke JW. Lipoproteomics: using mass spectrometry-based proteomics to explore the assembly, structure, and function of lipoproteins. Journal of Lipid Research. 50: 1967-75. PMID 19738003 DOI: 10.1194/jlr.R900015-JLR200  0.253
2006 Fu X, Wang Y, Kao J, Irwin A, d'Avignon A, Mecham RP, Parks WC, Heinecke JW. Specific sequence motifs direct the oxygenation and chlorination of tryptophan by myeloperoxidase. Biochemistry. 45: 3961-71. PMID 16548523 DOI: 10.1021/Bi052339+  0.253
2020 Vaisar T, Hu JH, Airhart N, Fox KA, Heinecke JW, Nicosia RF, Kohler TR, Potter ZE, Simon GM, Dix M, Cravatt B, Gharib SA, Dichek D. Parallel Murine and Human Plaque Proteomics Reveals Pathways of Plaque Rupture. Circulation Research. PMID 32762496 DOI: 10.1161/Circresaha.120.317295  0.251
2010 Cavigiolio G, Geier EG, Shao B, Heinecke JW, Oda MN. Exchange of apolipoprotein A-I between lipid-associated and lipid-free states: a potential target for oxidative generation of dysfunctional high density lipoproteins. The Journal of Biological Chemistry. 285: 18847-57. PMID 20385548 DOI: 10.1074/Jbc.M109.098434  0.251
2001 Henderson JP, Byun J, Williams MV, McCormick ML, Parks WC, Ridnour LA, Heinecke JW. Bromination of deoxycytidine by eosinophil peroxidase: a mechanism for mutagenesis by oxidative damage of nucleotide precursors. Proceedings of the National Academy of Sciences of the United States of America. 98: 1631-6. PMID 11172002 DOI: 10.1073/Pnas.041146998  0.25
2001 Henderson JP, Byun J, Williams MV, McCormick ML, Parks WC, Ridnour LA, Heinecke JW. Bromination of deoxycytidine by eosinophil peroxidase: A mechanism for mutagenesis by oxidative damage of nucleotide precursors Proceedings of the National Academy of Sciences. 98: 1631-1636. DOI: 10.1073/Pnas.98.4.1631  0.25
2019 He Y, Song HD, Anantharamaiah GM, Palgunachari MN, Bornfeldt KE, Segrest JP, Heinecke JW. Apolipoprotein A1 Forms 5/5 and 5/4 Antiparallel Dimers in Human High-density Lipoprotein. Molecular & Cellular Proteomics : McP. 18: 854-864. PMID 33451786 DOI: 10.1074/mcp.RA118.000878  0.249
1996 Francis GA, Oram JF, Heinecke JW, Bierman EL. Oxidative tyrosylation of HDL enhances the depletion of cellular cholesteryl esters by a mechanism independent of passive sterol desorption. Biochemistry. 35: 15188-97. PMID 8952466 DOI: 10.1021/bi9618169  0.245
2019 He Y, Song HD, Anantharamaiah GM, Palgunachari MN, Bornfeldt K, Segrest JP, Heinecke J. Apolipoprotein A1 forms 5/5 and 5/4 antiparallel dimers in human high-density lipoprotein. Molecular & Cellular Proteomics : McP. PMID 30659061 DOI: 10.1074/Mcp.Ra118.000878  0.245
1997 Leeuwenburgh C, Rasmussen JE, Hsu FF, Mueller DM, Pennathur S, Heinecke JW. Mass spectrometric quantification of markers for protein oxidation by tyrosyl radical, copper, and hydroxyl radical in low density lipoprotein isolated from human atherosclerotic plaques. The Journal of Biological Chemistry. 272: 3520-6. PMID 9013599 DOI: 10.1074/Jbc.272.6.3520  0.244
2021 Josefs T, Basu D, Vaisar T, Arets B, Kanter JE, Huggins LA, Hu Y, Liu J, Clouet-Foraison N, Heinecke JW, Bornfeldt KE, Goldberg IJ, Fisher EA. Atherosclerosis Regression and Cholesterol Efflux in Hypertriglyceridemic Mice. Circulation Research. PMID 33530703 DOI: 10.1161/CIRCRESAHA.120.317458  0.243
2001 Brown KE, Brunt EM, Heinecke JW. Immunohistochemical detection of myeloperoxidase and its oxidation products in Kupffer cells of human liver. The American Journal of Pathology. 159: 2081-8. PMID 11733358 DOI: 10.1016/S0002-9440(10)63059-3  0.243
2015 Pamir N, Hutchins P, Ronsein G, Vaisar T, Reardon CA, Getz GS, Lusis AJ, Heinecke JW. Proteomic analysis of HDL from inbred mice strains implicates APOE associated with HDL in reduced cholesterol efflux capacity via the ABCA1 pathway. Journal of Lipid Research. PMID 26673204 DOI: 10.1194/Jlr.M063701  0.242
1991 Heinecke JW, Suits AG, Aviram M, Chait A. Phagocytosis of lipase-aggregated low density lipoprotein promotes macrophage foam cell formation. Sequential morphological and biochemical events. Arteriosclerosis and Thrombosis : a Journal of Vascular Biology / American Heart Association. 11: 1643-51. PMID 1657129  0.241
2010 Suzuki M, Pritchard DK, Becker L, Hoofnagle AN, Tanimura N, Bammler TK, Beyer RP, Bumgarner R, Vaisar T, de Beer MC, de Beer FC, Miyake K, Oram JF, Heinecke JW. High-density lipoprotein suppresses the type I interferon response, a family of potent antiviral immunoregulators, in macrophages challenged with lipopolysaccharide. Circulation. 122: 1919-27. PMID 20974999 DOI: 10.1161/Circulationaha.110.961193  0.239
2019 BUCKNER T, BORNFELDT K, HEINECKE J, VAISAR T, SNELL-BERGEON JK. 1569-P: Cholesterol Efflux Capacity (CEC) and HDL Subspecies Associate with Estimated Insulin Sensitivity (eIS) in Type 1 Diabetes (T1D) Diabetes. 68: 1569-P. DOI: 10.2337/Db19-1569-P  0.239
2006 Vaisar T, Heinecke JW. Oxidation of Artery Wall Proteins by Myeloperoxidase: A Proteomics Approach Redox Proteomics: From Protein Modifications to Cellular Dysfunction and Diseases. 787-811. DOI: 10.1002/0471973122.ch24  0.239
2001 Henderson JP, Byun J, Williams MV, Mueller DM, McCormick ML, Heinecke JW. Production of brominating intermediates by myeloperoxidase. A transhalogenation pathway for generating mutagenic nucleobases during inflammation. The Journal of Biological Chemistry. 276: 7867-75. PMID 11096071 DOI: 10.1074/Jbc.M005379200  0.237
1989 Suits AG, Chait A, Aviram M, Heinecke JW. Phagocytosis of aggregated lipoprotein by macrophages: low density lipoprotein receptor-dependent foam-cell formation. Proceedings of the National Academy of Sciences of the United States of America. 86: 2713-7. PMID 2704743  0.236
2006 Gurer-Orhan H, Ercal N, Mare S, Pennathur S, Orhan H, Heinecke JW. Misincorporation of free m-tyrosine into cellular proteins: a potential cytotoxic mechanism for oxidized amino acids. The Biochemical Journal. 395: 277-84. PMID 16363993 DOI: 10.1042/Bj20051964  0.236
2007 Shepherd J, Hilderbrand SA, Waterman P, Heinecke JW, Weissleder R, Libby P. A fluorescent probe for the detection of myeloperoxidase activity in atherosclerosis-associated macrophages. Chemistry & Biology. 14: 1221-31. PMID 18022561 DOI: 10.1016/J.Chembiol.2007.10.005  0.235
2019 Fotakis P, Kothari V, Thomas DG, Westerterp M, Molusky MM, Altin E, Abramowicz S, Wang N, He Y, Heinecke JW, Bornfeldt KE, Tall AR. Anti-Inflammatory Effects of HDL (High-Density Lipoprotein) in Macrophages Predominate Over Proinflammatory Effects in Atherosclerotic Plaques. Arteriosclerosis, Thrombosis, and Vascular Biology. ATVBAHA119313253. PMID 31578081 DOI: 10.1161/ATVBAHA.119.313253  0.234
2015 Vaisar T, Tang C, Babenko I, Hutchins P, Wimberger J, Suffredini AF, Heinecke JW. Inflammatory remodeling of the HDL proteome impairs cholesterol efflux capacity. Journal of Lipid Research. 56: 1519-30. PMID 25995210 DOI: 10.1194/jlr.M059089  0.233
2010 Heinecke JW. The protein cargo of HDL: implications for vascular wall biology and therapeutics. Journal of Clinical Lipidology. 4: 371-5. PMID 20975842 DOI: 10.1016/j.jacl.2010.08.005  0.233
2017 Shao B, Heinecke JW. Quantifying HDL proteins by mass spectrometry: how many proteins are there and what are their functions? Expert Review of Proteomics. PMID 29113513 DOI: 10.1080/14789450.2018.1402680  0.232
2010 Cheung MC, Vaisar T, Han X, Heinecke JW, Albers JJ. Phospholipid transfer protein in human plasma associates with proteins linked to immunity and inflammation. Biochemistry. 49: 7314-22. PMID 20666409 DOI: 10.1021/bi100359f  0.232
2015 Ronsein GE, Pamir N, von Haller PD, Kim DS, Oda MN, Jarvik GP, Vaisar T, Heinecke JW. Parallel reaction monitoring (PRM) and selected reaction monitoring (SRM) exhibit comparable linearity, dynamic range and precision for targeted quantitative HDL proteomics. Journal of Proteomics. 113: 388-99. PMID 25449833 DOI: 10.1016/J.Jprot.2014.10.017  0.232
1999 Pennathur S, Jackson-Lewis V, Przedborski S, Heinecke JW. Mass spectrometric quantification of 3-nitrotyrosine, ortho-tyrosine, and o,o'-dityrosine in brain tissue of 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine-treated mice, a model of oxidative stress in Parkinson's disease. The Journal of Biological Chemistry. 274: 34621-8. PMID 10574926 DOI: 10.1074/Jbc.274.49.34621  0.232
2005 Passarelli M, Tang C, McDonald TO, O'Brien KD, Gerrity RG, Heinecke JW, Oram JF. Advanced glycation end product precursors impair ABCA1-dependent cholesterol removal from cells. Diabetes. 54: 2198-205. PMID 15983222 DOI: 10.2337/diabetes.54.7.2198  0.231
2003 Heinecke JW. Clinical trials of vitamin E in coronary artery disease: is it time to reconsider the low-density lipoprotein oxidation hypothesis? Current Atherosclerosis Reports. 5: 83-7. PMID 12573190 DOI: 10.1007/s11883-003-0075-1  0.231
2006 Shao B, Oda MN, Oram JF, Heinecke JW. Myeloperoxidase: an inflammatory enzyme for generating dysfunctional high density lipoprotein. Current Opinion in Cardiology. 21: 322-8. PMID 16755201 DOI: 10.1097/01.hco.0000231402.87232.aa  0.229
2007 Pennathur S, Heinecke JW. Mechanisms for oxidative stress in diabetic cardiovascular disease. Antioxidants & Redox Signaling. 9: 955-69. PMID 17508917 DOI: 10.1089/ars.2007.1595  0.229
1989 Heinecke JW, Shapiro BM. Respiratory burst oxidase of fertilization. Proceedings of the National Academy of Sciences of the United States of America. 86: 1259-63. PMID 2537493 DOI: 10.1073/Pnas.86.4.1259  0.228
2012 Becker L, Liu NC, Averill MM, Yuan W, Pamir N, Peng Y, Irwin AD, Fu X, Bornfeldt KE, Heinecke JW. Unique proteomic signatures distinguish macrophages and dendritic cells. Plos One. 7: e33297. PMID 22428014 DOI: 10.1371/Journal.Pone.0033297  0.227
1999 Heinecke JW. Mechanisms of oxidative damage by myeloperoxidase in atherosclerosis and other inflammatory disorders. The Journal of Laboratory and Clinical Medicine. 133: 321-5. PMID 10218761 DOI: 10.1016/S0022-2143(99)90061-6  0.227
1998 Leeuwenburgh C, Hansen P, Shaish A, Holloszy JO, Heinecke JW. Markers of protein oxidation by hydroxyl radical and reactive nitrogen species in tissues of aging rats. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 274: R453-R461. PMID 29587033 DOI: 10.1152/ajpregu.1998.274.2.R453  0.226
2009 Fu X, Parks WC, Heinecke JW. Retraction notice to "Activation and silencing of matrix metalloproteinases" [Semin. Cell Dev. Biol. 19 (2008) 2-13] (DOI:10.1016/j.semcdb.2007.06.005) Seminars in Cell and Developmental Biology. 20: 375. PMID 19530279 DOI: 10.1016/j.semcdb.2008.10.009  0.225
2020 Costacou T, Vaisar T, Ju J, Bornfeldt K, Orchard TJ, Heinecke J. 1419-P: Lower Medium and Total HDL Particle Concentrations May Contribute to CVD Risk in Type 1 Diabetes Diabetes. 69. DOI: 10.2337/Db20-1419-P  0.225
2019 Pamir N, Pan C, Plubell DL, Hutchins PM, Tang C, Wimberger J, Irwin A, Vallim TQA, Heinecke JW, Lusis AJ. Genetic control of the mouse HDL proteome defines HDL traits, function, and heterogeneity. Journal of Lipid Research. PMID 30622162 DOI: 10.1194/Jlr.M090555  0.224
2015 Shao B, de Boer I, Tang C, Mayer PS, Zelnick L, Afkarian M, Heinecke JW, Himmelfarb J. A Cluster of Proteins Implicated in Kidney Disease Is Increased in High-Density Lipoprotein Isolated from Hemodialysis Subjects. Journal of Proteome Research. 14: 2792-806. PMID 26011469 DOI: 10.1021/Acs.Jproteome.5B00060  0.223
2021 Shimizu-Albergine M, Basu D, Kanter JE, Kramer F, Kothari V, Barnhart S, Thornock C, Mullick AE, Clouet-Foraison N, Vaisar T, Heinecke JW, Hegele RA, Goldberg IJ, Bornfeldt KE. CREBH normalizes dyslipidemia and halts atherosclerosis in diabetes by decreasing circulating remnant lipoproteins. The Journal of Clinical Investigation. PMID 34491909 DOI: 10.1172/JCI153285  0.221
1998 Oh-ishi S, Miyazaki H, Heinecke J, Fujii C, Kizaki T, Ookawara T, Haga S, Nakao C, Sato Y, Ohno H. p-hydroxyphenylacetaldehyde (pHA), a product of l-tyrosine oxidation by the myeloperoxidase system of phagocytes, inhibits angiogenesis Pathophysiology. 5: 172. DOI: 10.1016/S0928-4680(98)80961-9  0.221
1999 Leeuwenburgh C, Hansen PA, Holloszy JO, Heinecke JW. Oxidized amino acids in the urine of aging rats: potential markers for assessing oxidative stress in vivo. The American Journal of Physiology. 276: R128-35. PMID 9887186 DOI: 10.1152/Ajpregu.1999.276.1.R128  0.221
2015 Pamir N, Liu NC, Irwin A, Becker L, Peng Y, Ronsein GE, Bornfeldt KE, Duffield JS, Heinecke JW. Granulocyte/Macrophage Colony-stimulating Factor-dependent Dendritic Cells Restrain Lean Adipose Tissue Expansion. The Journal of Biological Chemistry. 290: 14656-67. PMID 25931125 DOI: 10.1074/Jbc.M115.645820  0.219
2005 Vasilyev N, Williams T, Brennan ML, Unzek S, Zhou X, Heinecke JW, Spitz DR, Topol EJ, Hazen SL, Penn MS. Myeloperoxidase-generated oxidants modulate left ventricular remodeling but not infarct size after myocardial infarction. Circulation. 112: 2812-20. PMID 16267254 DOI: 10.1161/Circulationaha.105.542340  0.217
2000 Manary MJ, Leeuwenburgh C, Heinecke JW. Increased oxidative stress in kwashiorkor. The Journal of Pediatrics. 137: 421-4. PMID 10969271 DOI: 10.1067/Mpd.2000.107512  0.215
2008 Green PS, Vaisar T, Pennathur S, Kulstad JJ, Moore AB, Marcovina S, Brunzell J, Knopp RH, Zhao XQ, Heinecke JW. Combined statin and niacin therapy remodels the high-density lipoprotein proteome. Circulation. 118: 1259-67. PMID 18765395 DOI: 10.1161/CIRCULATIONAHA.108.770669  0.214
2013 Vivekanandan-Giri A, Slocum JL, Byun J, Tang C, Sands RL, Gillespie BW, Heinecke JW, Saran R, Kaplan MJ, Pennathur S. High density lipoprotein is targeted for oxidation by myeloperoxidase in rheumatoid arthritis. Annals of the Rheumatic Diseases. 72: 1725-31. PMID 23313808 DOI: 10.1136/Annrheumdis-2012-202033  0.214
2009 Gross S, Gammon ST, Moss BL, Rauch D, Harding J, Heinecke JW, Ratner L, Piwnica-Worms D. Bioluminescence imaging of myeloperoxidase activity in vivo. Nature Medicine. 15: 455-61. PMID 19305414 DOI: 10.1038/Nm.1886  0.213
1998 Hazen SL, d'Avignon A, Anderson MM, Hsu FF, Heinecke JW. Human neutrophils employ the myeloperoxidase-hydrogen peroxide-chloride system to oxidize alpha-amino acids to a family of reactive aldehydes. Mechanistic studies identifying labile intermediates along the reaction pathway. The Journal of Biological Chemistry. 273: 4997-5005. PMID 9478947 DOI: 10.1074/Jbc.273.9.4997  0.212
2001 Leeuwenburgh C, Heinecke JW. Oxidative stress and antioxidants in exercise. Current Medicinal Chemistry. 8: 829-38. PMID 11375753 DOI: 10.2174/0929867013372896  0.211
2011 Chiba T, Chang MY, Wang S, Wight TN, McMillen TS, Oram JF, Vaisar T, Heinecke JW, De Beer FC, De Beer MC, Chait A. Serum amyloid A facilitates the binding of high-density lipoprotein from mice injected with lipopolysaccharide to vascular proteoglycans. Arteriosclerosis, Thrombosis, and Vascular Biology. 31: 1326-32. PMID 21474830 DOI: 10.1161/Atvbaha.111.226159  0.211
2022 Shao B, Snell-Bergeon JK, Pyle LL, Thomas KE, de Boer IH, Kothari V, Segrest J, Davidson WS, Bornfeldt KE, Heinecke JW. Pulmonary Surfactant Protein B Carried by HDL Predicts Incident Cardiovascular Disease in Patients with Type 1 Diabetes. Journal of Lipid Research. 100196. PMID 35300983 DOI: 10.1016/j.jlr.2022.100196  0.209
1999 Gokce N, Keaney JF, Frei B, Holbrook M, Olesiak M, Zachariah BJ, Leeuwenburgh C, Heinecke JW, Vita JA. Long-term ascorbic acid administration reverses endothelial vasomotor dysfunction in patients with coronary artery disease. Circulation. 99: 3234-40. PMID 10385496 DOI: 10.1161/01.Cir.99.25.3234  0.209
2001 Bhattacharjee S, Pennathur S, Byun J, Crowley J, Mueller D, Gischler J, Hotchkiss RS, Heinecke JW. NADPH oxidase of neutrophils elevates o,o'-dityrosine cross-links in proteins and urine during inflammation. Archives of Biochemistry and Biophysics. 395: 69-77. PMID 11673867 DOI: 10.1006/abbi.2001.2557  0.208
2007 Chang DW, Colucci G, Vaisar T, King T, Hayashi S, Matute-Bello G, Bumgarner R, Heinecke J, Martin TR, Domenighetti GM. Proteomic analysis of two non-bronchoscopic methods of sampling the lungs of patients with the acute respiratory distress syndrome (ARDS) Clinical Proteomics. 3: 30-41. DOI: 10.1007/S12014-007-9002-8  0.208
2013 Oda MN, Budamagunta MS, Geier EG, Chandradas SH, Shao B, Heinecke JW, Voss JC, Cavigiolio G. Conservation of apolipoprotein A-I's central domain structural elements upon lipid association on different high-density lipoprotein subclasses. Biochemistry. 52: 6766-78. PMID 23984834 DOI: 10.1021/Bi4007012  0.207
2012 Gomez IG, Tang J, Wilson CL, Yan W, Heinecke JW, Harlan JM, Raines EW. Metalloproteinase-mediated Shedding of Integrin β2 promotes macrophage efflux from inflammatory sites. The Journal of Biological Chemistry. 287: 4581-9. PMID 22170060 DOI: 10.1074/Jbc.M111.321182  0.207
2023 Merrill NJ, Davidson WS, He Y, Díaz Ludovico I, Sarkar S, Berger MR, McDermott JE, Van Eldik LJ, Wilcock DM, Monroe ME, Kyle JE, Bruce KD, Heinecke JW, Vaisar T, Raber J, et al. Human cerebrospinal fluid contains diverse lipoprotein subspecies enriched in proteins implicated in central nervous system health. Science Advances. 9: eadi5571. PMID 37647397 DOI: 10.1126/sciadv.adi5571  0.204
1999 Leeuwenburgh C, Hansen PA, Holloszy JO, Heinecke JW. Hydroxyl radical generation during exercise increases mitochondrial protein oxidation and levels of urinary dityrosine. Free Radical Biology & Medicine. 27: 186-92. PMID 10443935 DOI: 10.1016/S0891-5849(99)00071-4  0.202
2019 Barrett TJ, Distel E, Murphy AJ, Hu J, Garshick MS, Ogando Y, Liu J, Vaisar T, Heinecke JW, Berger JS, Goldberg IJ, Fisher EA. Apolipoprotein AI) Promotes Atherosclerosis Regression in Diabetic Mice by Suppressing Myelopoiesis and Plaque Inflammation. Circulation. 140: 1170-1184. PMID 31567014 DOI: 10.1161/CIRCULATIONAHA.119.039476  0.202
1999 Heinecke JW. Biochemical evidence for a link between elevated levels of homocysteine and lipid peroxidation in vivo. Current Atherosclerosis Reports. 1: 87-9. PMID 11122696 DOI: 10.1007/s11883-999-0001-2  0.202
2021 Ronsein GE, Vaisar T, Davidson WS, Bornfeldt KE, Probstfield JL, O'Brien KD, Zhao XQ, Heinecke JW. Niacin Increases Atherogenic Proteins in High-Density Lipoprotein of Statin-Treated Subjects. Arteriosclerosis, Thrombosis, and Vascular Biology. ATVBAHA121316278. PMID 34134520 DOI: 10.1161/ATVBAHA.121.316278  0.201
2011 Averill MM, Barnhart S, Becker L, Li X, Heinecke JW, Leboeuf RC, Hamerman JA, Sorg C, Kerkhoff C, Bornfeldt KE. S100A9 differentially modifies phenotypic states of neutrophils, macrophages, and dendritic cells: implications for atherosclerosis and adipose tissue inflammation. Circulation. 123: 1216-26. PMID 21382888 DOI: 10.1161/Circulationaha.110.985523  0.2
2007 Pennathur S, Heinecke JW. Oxidative stress and endothelial dysfunction in vascular disease. Current Diabetes Reports. 7: 257-64. PMID 17686400 DOI: 10.1007/s11892-007-0041-3  0.199
2001 Kirk EA, Heinecke JW, LeBoeuf RC. Iron overload diminishes atherosclerosis in apoE-deficient mice. The Journal of Clinical Investigation. 107: 1545-53. PMID 11413162 DOI: 10.1172/Jci7664  0.198
2018 Cooke AL, Morris JC, Melchior JT, Jerome WG, Street SE, Thompson TB, Smith LE, Shah AS, Herr A, Segrest JP, Heinecke JW, Davidson WS. Abstract 026: Apolipoprotein A-I Helical Registry Modulates Lecithin:cholesterol Acyl Transferase Activity Arteriosclerosis, Thrombosis, and Vascular Biology. 38. DOI: 10.1161/Atvb.38.Suppl_1.026  0.198
2008 Kirk EA, Sagawa ZK, McDonald TO, O'Brien KD, Heinecke JW. Monocyte chemoattractant protein deficiency fails to restrain macrophage infiltration into adipose tissue [corrected]. Diabetes. 57: 1254-61. PMID 18268047 DOI: 10.2337/db07-1061  0.197
1997 Wagner P, Heinecke JW. Copper ions promote peroxidation of low density lipoprotein lipid by binding to histidine residues of apolipoprotein B100, but they are reduced at other sites on LDL. Arteriosclerosis, Thrombosis, and Vascular Biology. 17: 3338-46. PMID 9409331 DOI: 10.1161/01.ATV.17.11.3338  0.195
1986 Heinecke JW, Baker L, Rosen H, Chait A. Superoxide-mediated modification of low density lipoprotein by arterial smooth muscle cells. The Journal of Clinical Investigation. 77: 757-61. PMID 3005364 DOI: 10.1172/JCI112371  0.195
2023 He Y, Pavanello C, Hutchins PM, Tang C, Pourmousa M, Vaisar T, Song HD, Pastor RW, Remaley AT, Goldberg IJ, Costacou T, Davidson WS, Bornfeldt KE, Calabresi L, Segrest JP, ... Heinecke JW, et al. Flipped C-Terminal Ends of APOA1 Promote ABCA1-dependent Cholesterol Efflux by Small HDLs. Medrxiv : the Preprint Server For Health Sciences. PMID 37961344 DOI: 10.1101/2023.11.03.23297986  0.194
2010 Becker L, Gharib SA, Irwin AD, Wijsman E, Vaisar T, Oram JF, Heinecke JW. A macrophage sterol-responsive network linked to atherogenesis. Cell Metabolism. 11: 125-35. PMID 20142100 DOI: 10.1016/J.Cmet.2010.01.003  0.193
2013 Campanholle G, Mittelsteadt K, Nakagawa S, Kobayashi A, Lin SL, Gharib SA, Heinecke JW, Hamerman JA, Altemeier WA, Duffield JS. TLR-2/TLR-4 TREM-1 signaling pathway is dispensable in inflammatory myeloid cells during sterile kidney injury. Plos One. 8: e68640. PMID 23844229 DOI: 10.1371/Journal.Pone.0068640  0.192
2023 He Y, Pavanello C, Hutchins PM, Tang C, Pourmousa M, Vaisar T, Song HD, Pastor RW, Remaley AT, Goldberg IJ, Costacou T, Sean Davidson W, Bornfeldt KE, Calabresi L, Segrest JP, ... Heinecke JW, et al. Flipped C-Terminal Ends of apoA1 Promote ABCA1-Dependent Cholesterol Efflux by Small HDLs. Circulation. PMID 38018436 DOI: 10.1161/CIRCULATIONAHA.123.065959  0.192
2009 Shao B, Heinecke JW. HDL, lipid peroxidation, and atherosclerosis. Journal of Lipid Research. 50: 599-601. PMID 19141435 DOI: 10.1194/jlr.E900001-JLR200  0.192
2005 Choi DK, Pennathur S, Perier C, Tieu K, Teismann P, Wu DC, Jackson-Lewis V, Vila M, Vonsattel JP, Heinecke JW, Przedborski S. Ablation of the inflammatory enzyme myeloperoxidase mitigates features of Parkinson's disease in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 6594-600. PMID 16014720 DOI: 10.1523/Jneurosci.0970-05.2005  0.191
2008 Cavigiolio G, Shao B, Geier EG, Ren G, Heinecke JW, Oda MN. The interplay between size, morphology, stability, and functionality of high-density lipoprotein subclasses. Biochemistry. 47: 4770-9. PMID 18366184 DOI: 10.1021/Bi7023354  0.191
2015 Hutchins PM, Heinecke JW. Cholesterol efflux capacity, macrophage reverse cholesterol transport and cardioprotective HDL. Current Opinion in Lipidology. 26: 388-93. PMID 26270810 DOI: 10.1097/MOL.0000000000000209  0.189
2004 Pennathur S, Heinecke JW. Mechanisms of oxidative stress in diabetes: implications for the pathogenesis of vascular disease and antioxidant therapy. Frontiers in Bioscience : a Journal and Virtual Library. 9: 565-74. PMID 14766391 DOI: 10.2741/1257  0.189
1997 Semenkovich CF, Heinecke JW. The mystery of diabetes and atherosclerosis: time for a new plot. Diabetes. 46: 327-34. PMID 9032085 DOI: 10.2337/Diab.46.3.327  0.188
1998 Byun J, Henderson J, Mueller D, Heinecke J. 8-nitro-2′-deoxyguanosine is generated by the myeloperoxidase-H2O2-nitrite system of activated human phagocytes Free Radical Biology and Medicine. 25: S115. DOI: 10.1016/S0891-5849(98)90353-7  0.186
2015 Tang C, Liu Y, Yang W, Storey C, Mcmillen TS, Houston BA, Heinecke JW, LeBoeuf RC. Hematopoietic ABCA1 deletion promotes monocytosis and worsens diet-induced insulin resistance in mice. Journal of Lipid Research. PMID 26531812 DOI: 10.1194/Jlr.M064303  0.186
1997 Huff M, Whitman S, Hazen S, Heinecke J, Miller D, Hegele R. 3.P.115 Modification of type III VLDL, their remnants and VLDL from apoE-knockout mice by p-hydroxyphenylacetaldehyde, causes marked macrophage cholesteryl ester accumulation Atherosclerosis. 134: 222. DOI: 10.1016/S0021-9150(97)89189-7  0.183
2012 Rubinow KB, Vaisar T, Tang C, Matsumoto AM, Heinecke JW, Page ST. Testosterone replacement in hypogonadal men alters the HDL proteome but not HDL cholesterol efflux capacity. Journal of Lipid Research. 53: 1376-83. PMID 22504910 DOI: 10.1194/jlr.P026005  0.181
1984 Heinecke JW, Rosen H, Chait A. Iron and copper promote modification of low density lipoprotein by human arterial smooth muscle cells in culture. The Journal of Clinical Investigation. 74: 1890-4. PMID 6501577 DOI: 10.1172/JCI111609  0.181
2017 Melchior JT, Walker RG, Cooke AL, Morris J, Castleberry M, Thompson TB, Jones MK, Song HD, Rye KA, Oda MN, Sorci-Thomas MG, Thomas MJ, Heinecke JW, Mei X, Atkinson D, et al. A consensus model of human apolipoprotein A-I in its monomeric and lipid-free state. Nature Structural & Molecular Biology. PMID 29131142 DOI: 10.1038/Nsmb.3501  0.181
2019 Kanter JE, Shao B, Kramer F, Barnhart S, Shimizu-Albergine M, Vaisar T, Graham MJ, Crooke RM, Manuel CR, Haeusler RA, Mar D, Bomsztyk K, Hokanson JE, Kinney GL, Snell-Bergeon JK, ... Heinecke JW, et al. Increased apolipoprotein C3 drives cardiovascular risk in type 1 diabetes. The Journal of Clinical Investigation. 130. PMID 31295146 DOI: 10.1172/Jci127308  0.18
2008 Xiao C, Watanabe T, Zhang Y, Trigatti B, Szeto L, Connelly PW, Marcovina S, Vaisar T, Heinecke JW, Lewis GF. Enhanced cellular uptake of remnant high-density lipoprotein particles: a mechanism for high-density lipoprotein lowering in insulin resistance and hypertriglyceridemia. Circulation Research. 103: 159-66. PMID 18556574 DOI: 10.1161/Circresaha.108.178756  0.18
2018 Pourmousa M, Song HD, He Y, Heinecke JW, Segrest JP, Pastor RW. Tertiary structure of apolipoprotein A-I in nascent high-density lipoproteins. Proceedings of the National Academy of Sciences of the United States of America. PMID 29712830 DOI: 10.1073/pnas.1721181115  0.179
2020 He Y, Ronsein GE, Tang C, Jarvik GP, Davidson WS, Kothari V, Song HD, Segrest J, Bornfeldt KE, Heinecke JW. Diabetes Impairs Cellular Cholesterol Efflux from ABCA1 to Small HDL Particles. Circulation Research. PMID 32819213 DOI: 10.1161/Circresaha.120.317178  0.179
2009 Shao B, Oda M, Oram J, Heinecke J. Abstract: 1457 MODIFICATION OF APOLIPOPROTEIN A-I BY MALONDIALDEHYDE, BUT NOT BY AN ARRAY OF OTHER REACTIVE CARBONYLS, BLOCKS CHOLESTEROL EFFLUX BY THE ABCA1 PATHWAY Atherosclerosis Supplements. 10: e97. DOI: 10.1016/S1567-5688(09)70102-3  0.178
2012 Kanter JE, Kramer F, Barnhart S, Averill MM, Vivekanandan-Giri A, Vickery T, Li LO, Becker L, Yuan W, Chait A, Braun KR, Potter-Perigo S, Sanda S, Wight TN, Pennathur S, ... ... Heinecke JW, et al. Diabetes promotes an inflammatory macrophage phenotype and atherosclerosis through acyl-CoA synthetase 1. Proceedings of the National Academy of Sciences of the United States of America. 109: E715-24. PMID 22308341 DOI: 10.1073/Pnas.1111600109  0.177
2001 Kulcharyk PA, Heinecke JW. Hypochlorous acid produced by the myeloperoxidase system of human phagocytes induces covalent cross-links between DNA and protein. Biochemistry. 40: 3648-56. PMID 11297432 DOI: 10.1021/bi001962l  0.176
2006 Chiba T, Han C, Vaughan a, Heinecke J, Chait A, Oram J. Tu-P7:191 Inflammation impairs the ability of mouse serum to remove cellular lipids by the ABCA1 pathway Atherosclerosis Supplements. 7: 227. DOI: 10.1016/S1567-5688(06)80896-2  0.173
2009 Chiba T, Han CY, Vaisar T, Shimokado K, Kargi A, Chen MH, Wang S, McDonald TO, O'Brien KD, Heinecke JW, Chait A. Serum amyloid A3 does not contribute to circulating SAA levels. Journal of Lipid Research. 50: 1353-62. PMID 19286646 DOI: 10.1194/jlr.M900089-JLR200  0.169
2013 Toth PP, Barter PJ, Rosenson RS, Boden WE, Chapman MJ, Cuchel M, D'Agostino RB, Davidson MH, Davidson WS, Heinecke JW, Karas RH, Kontush A, Krauss RM, Miller M, Rader DJ. High-density lipoproteins: a consensus statement from the National Lipid Association. Journal of Clinical Lipidology. 7: 484-525. PMID 24079290 DOI: 10.1016/J.Jacl.2013.08.001  0.169
2015 Heinecke JW. Small HDL promotes cholesterol efflux by the ABCA1 pathway in macrophages: implications for therapies targeted to HDL. Circulation Research. 116: 1101-3. PMID 25814677 DOI: 10.1161/CIRCRESAHA.115.306052  0.168
2020 Heinecke JW. Does HDL (High-Density Lipoprotein) Play a Causal Role in Host Defenses Against Infection? Arteriosclerosis, Thrombosis, and Vascular Biology. 40: 5-6. PMID 31869273 DOI: 10.1161/ATVBAHA.119.313651  0.167
1990 Heinecke JW, Shapiro BM. Protein kinase C activates the respiratory burst of fertilization, but not cortical granule exocytosis, in ionophore-stimulated sea urchin eggs. Developmental Biology. 142: 216-23. PMID 2227097 DOI: 10.1016/0012-1606(90)90165-F  0.167
2015 Ronsein GE, Reyes-Soffer G, He Y, Oda M, Ginsberg H, Heinecke JW. Targeted Proteomics Identifies PON1 and Apolipoprotein Cs as Potential Risk Factors for Hypoalphalipoproteinemia in Diabetic Subjects Treated with Fenofibrate and Rosiglitazone. Molecular & Cellular Proteomics : McP. PMID 26667175 DOI: 10.1074/mcp.M115.054528  0.166
1999 Heinecke JW. Is lipid peroxidation relevant to atherogenesis? The Journal of Clinical Investigation. 104: 135-6. PMID 10411541 DOI: 10.1172/JCI7633  0.166
2019 Shea S, Stein JH, Jorgensen NW, McClelland RL, Tascau L, Shrager S, Heinecke JW, Yvan-Charvet L, Tall AR. Cholesterol Mass Efflux Capacity, Incident Cardiovascular Disease, and Progression of Carotid Plaque. Arteriosclerosis, Thrombosis, and Vascular Biology. 39: 89-96. PMID 30580560 DOI: 10.1161/Atvbaha.118.311366  0.166
2023 Costacou T, Vaisar T, Miller RG, Davidson WS, Heinecke JW, Orchard TJ, Bornfeldt KE. HDL Particle Concentration and Size Predict Incident Coronary Artery Disease Events in People with Type 1 Diabetes. Medrxiv : the Preprint Server For Health Sciences. PMID 37986833 DOI: 10.1101/2023.11.06.23298165  0.165
2008 Oram JF, Heinecke JW. When good cholesterol turns bad: the evolving saga of CETP inhibitors and clinical strategies to elevate high-density lipoprotein. Current Diabetes Reports. 8: 165-7. PMID 18625111 DOI: 10.1007/s11892-008-0028-8  0.165
2007 Oram JF, Heinecke JW. When good cholesterol turns bad: the evolving saga of CETP inhibitors and clinical strategies to elevate high-density lipoprotein. Current Atherosclerosis Reports. 9: 425-7. PMID 18377780 DOI: 10.1007/s11883-007-0055-y  0.165
2019 Shao B, Zelnick LR, Wimberger J, Himmelfarb J, Brunzell J, Davidson WS, Snell-Bergeon JK, Bornfeldt KE, de Boer IH, Heinecke JW. Albuminuria, the HDL (High-Density Lipoprotein) Proteome, and Coronary Artery Calcification in Type 1 Diabetes Mellitus. Arteriosclerosis, Thrombosis, and Vascular Biology. ATVBAHA119312556. PMID 31092010 DOI: 10.1161/Atvbaha.119.312556  0.164
2018 Plubell DL, Fenton AM, Wilmarth PA, Bergstrom P, Zhao Y, Minnier J, Heinecke JW, Yang X, Pamir N. GM-CSF driven myeloid cells in adipose tissue link weight gain and insulin resistance via formation of 2-aminoadipate. Scientific Reports. 8: 11485. PMID 30065264 DOI: 10.1038/S41598-018-29250-8  0.164
1998 Heinecke JW, Lusis AJ. Paraoxonase-gene polymorphisms associated with coronary heart disease: support for the oxidative damage hypothesis? American Journal of Human Genetics. 62: 20-4. PMID 9443884 DOI: 10.1086/301691  0.164
2023 Segrest JP, Davidson WS, Heinecke JW. Phospholipid transport by ABCA1: the extracellular translocase or alternating access model? Current Opinion in Lipidology. PMID 37548415 DOI: 10.1097/MOL.0000000000000895  0.164
2015 Ronsein GE, Hutchins PM, Isquith D, Vaisar T, Zhao XQ, Heinecke JW. Niacin Therapy Increases High-Density Lipoprotein Particles and Total Cholesterol Efflux Capacity But Not ABCA1-Specific Cholesterol Efflux in Statin-Treated Subjects. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 26681752 DOI: 10.1161/ATVBAHA.115.306268  0.164
2012 Rubinow KB, Tang C, Hoofnagle AN, Snyder CN, Amory JK, Heinecke JW, Page ST. Acute sex steroid withdrawal increases cholesterol efflux capacity and HDL-associated clusterin in men. Steroids. 77: 454-60. PMID 22266332 DOI: 10.1016/j.steroids.2012.01.002  0.163
1987 Heinecke JW. Free radical modification of low-density lipoprotein: mechanisms and biological consequences. Free Radical Biology & Medicine. 3: 65-73. PMID 3040538 DOI: 10.1016/0891-5849(87)90040-2  0.159
2022 Bedi S, Morris J, Shah A, Hart RC, Jerome WG, Aller SG, Tang C, Vaisar T, Bornfeldt KE, Segrest JP, Heinecke JW, Davidson WS. Conformational Flexibility of Apolipoprotein A-I amino- and carboxy-Termini is necessary for Lipid Binding but not Cholesterol Efflux. Journal of Lipid Research. 100168. PMID 35051413 DOI: 10.1016/j.jlr.2022.100168  0.157
2012 Page ST, Krauss RM, Gross C, Ishida B, Heinecke JW, Tang C, Amory JK, Schaefer PM, Cox CJ, Kane J, Purnell JQ, Weinstein RL, Vaisar T. Impact of mifepristone, a glucocorticoid/progesterone antagonist, on HDL cholesterol, HDL particle concentration, and HDL function. The Journal of Clinical Endocrinology and Metabolism. 97: 1598-605. PMID 22399518 DOI: 10.1210/jc.2011-2813  0.156
1997 Leeuwenburgh C, Wagner P, Holloszy JO, Sohal RS, Heinecke JW. Caloric restriction attenuates dityrosine cross-linking of cardiac and skeletal muscle proteins in aging mice. Archives of Biochemistry and Biophysics. 346: 74-80. PMID 9328286 DOI: 10.1006/Abbi.1997.0297  0.153
2004 Green PS, Mendez AJ, Jacob JS, Crowley JR, Growdon W, Hyman BT, Heinecke JW. Neuronal expression of myeloperoxidase is increased in Alzheimer's disease. Journal of Neurochemistry. 90: 724-33. PMID 15255951 DOI: 10.1111/J.1471-4159.2004.02527.X  0.152
1996 Heinecke JW. Atherosclerosis: cell biology and lipoproteins. Current Opinion in Lipidology. 7: U131-6. PMID 8883508 DOI: 10.1097/00041433-199608000-00020  0.152
2014 Hutchins PM, Ronsein GE, Monette JS, Pamir N, Wimberger J, He Y, Anantharamaiah GM, Kim DS, Ranchalis JE, Jarvik GP, Vaisar T, Heinecke JW. Quantification of HDL particle concentration by calibrated ion mobility analysis. Clinical Chemistry. 60: 1393-401. PMID 25225166 DOI: 10.1373/Clinchem.2014.228114  0.151
1998 Leeuwenburgh C, Hansen P, Holloszy JO, Heinecke JW. EXERCISE INDUCES OXIDATIVE DAMAGE OF MITOCHONDRIAL PROTEINS Medicine & Science in Sports & Exercise. 30: 323. DOI: 10.1097/00005768-199805001-01833  0.151
2014 Segrest JP, Jones MK, Shao B, Heinecke JW. An experimentally robust model of monomeric apolipoprotein A-I created from a chimera of two X-ray structures and molecular dynamics simulations. Biochemistry. 53: 7625-40. PMID 25423138 DOI: 10.1021/bi501111j  0.15
2016 Monette JS, Hutchins PM, Ronsein GE, Wimberger J, Irwin AD, Tang C, Sara JD, Shao B, Vaisar T, Lerman A, Heinecke JW. Patients With Coronary Endothelial Dysfunction Have Impaired Cholesterol Efflux Capacity and Reduced HDL Particle Concentration. Circulation Research. PMID 27114438 DOI: 10.1161/CIRCRESAHA.116.308357  0.149
1994 Francis G, Oram J, Heinecke J, Bierman E. Tyrosylation of high density lipoprotein enhances excretion of intracellular cholesterol from cholesterol-loaded fibroblasts Atherosclerosis. 109: 232. DOI: 10.1016/0021-9150(94)93930-6  0.148
2007 Oram JF, Heinecke JW. Role of amphipathic α-helical structural elements in removing cellular cholesterol and protecting against cardiovascular disease Future Lipidology. 2: 185-196. DOI: 10.2217/17460875.2.2.185  0.148
2008 Hoofnagle AN, Becker JO, Wener MH, Heinecke JW. Quantification of thyroglobulin, a low-abundance serum protein, by immunoaffinity peptide enrichment and tandem mass spectrometry. Clinical Chemistry. 54: 1796-804. PMID 18801935 DOI: 10.1373/clinchem.2008.109652  0.147
2008 Fu X, Gharib SA, Green PS, Aitken ML, Frazer DA, Park DR, Vaisar T, Heinecke JW. Spectral index for assessment of differential protein expression in shotgun proteomics. Journal of Proteome Research. 7: 845-54. PMID 18198819 DOI: 10.1021/pr070271+  0.146
2009 Heinecke JW. A "new" thematic series: mass spectrometry-based proteomics of lipid biology. Journal of Lipid Research. 50: 777-80. PMID 19258282 DOI: 10.1194/jlr.E900002-JLR200  0.146
2016 El Khoudary SR, Hutchins PM, Matthews KA, Brooks MM, Orchard TJ, Ronsein GE, Heinecke JW. Cholesterol Efflux Capacity and Subclasses of HDL Particles in Healthy Women Transitioning Through Menopause. The Journal of Clinical Endocrinology and Metabolism. jc20162144. PMID 27399353 DOI: 10.1210/Jc.2016-2144  0.145
2013 Kawakami T, Lichtnekert J, Thompson LJ, Karna P, Bouabe H, Hohl TM, Heinecke JW, Ziegler SF, Nelson PJ, Duffield JS. Resident renal mononuclear phagocytes comprise five discrete populations with distinct phenotypes and functions. Journal of Immunology (Baltimore, Md. : 1950). 191: 3358-72. PMID 23956422 DOI: 10.4049/Jimmunol.1300342  0.145
2018 Rubinow KB, Vaisar T, Chao JH, Heinecke JW, Page ST. Sex steroids mediate discrete effects on HDL cholesterol efflux capacity and particle concentration in healthy men. Journal of Clinical Lipidology. PMID 29793828 DOI: 10.1016/j.jacl.2018.04.013  0.144
2017 Ronsein GE, Heinecke JW. Time to ditch HDL-C as a measure of HDL function? Current Opinion in Lipidology. PMID 28777110 DOI: 10.1097/MOL.0000000000000446  0.143
2006 Heinecke JW. Chemical knockout of C-reactive protein in cardiovascular disease. Nature Chemical Biology. 2: 300-1. PMID 16710337 DOI: 10.1038/nchembio0606-300  0.143
2008 Johansson F, Kramer F, Barnhart S, Kanter JE, Vaisar T, Merrill RD, Geng L, Oka K, Chan L, Chait A, Heinecke JW, Bornfeldt KE. Type 1 diabetes promotes disruption of advanced atherosclerotic lesions in LDL receptor-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. 105: 2082-7. PMID 18252823 DOI: 10.1073/pnas.0709958105  0.143
2013 Heinecke JW. HDL's protein cargo: friend or foe in cardioprotection? Circulation. 127: 868-9. PMID 23439444 DOI: 10.1161/CIRCULATIONAHA.112.000889  0.142
1990 Heinecke JW, Shapiro BM. Superoxidase peroxidase activity of ovoperoxidase Free Radical Biology and Medicine. 9: 2. DOI: 10.1016/0891-5849(90)90173-G  0.141
2020 Vaisar T, Gordon JL, Wimberger J, Heinecke JW, Hinderliter AL, Rubinow DR, Girdler SS, Rubinow KB. Perimenopausal transdermal estradiol replacement reduces serum HDL cholesterol efflux capacity but improves cardiovascular risk factors. Journal of Clinical Lipidology. PMID 33288437 DOI: 10.1016/j.jacl.2020.11.009  0.14
2018 Melchior JT, Street SE, Shah AS, Jerome WJ, Hart R, Heinecke JW, He Y, Andraski AB, Furtado JD, Sacks FM, Davidson WS. Abstract 556: Structural Characterization of Distinct Subparticles of Human High-density Lipoproteins Isolated from Plasma Arteriosclerosis, Thrombosis, and Vascular Biology. 38. DOI: 10.1161/Atvb.38.Suppl_1.556  0.139
2021 Melchior JT, Street SE, Vaisar T, Hart R, Jerome J, Kuklenyik Z, Clouet-Foraison N, Thornock C, Bedi S, Shah AS, Segrest JP, Heinecke JW, Davidson WS. Apolipoprotein A-I modulates HDL particle size in the absence of apolipoprotein A-II. Journal of Lipid Research. 100099. PMID 34324889 DOI: 10.1016/j.jlr.2021.100099  0.139
2020 Chait A, Ginsberg HN, Vaisar T, Heinecke JW, Goldberg IJ, Bornfeldt KE. Remnants of the Triglyceride-Rich Lipoproteins, Diabetes, and Cardiovascular Disease. Diabetes. 69: 508-516. PMID 32198194 DOI: 10.2337/dbi19-0007  0.138
2023 Jerome WGJ, Hart RC, Aller SG, Tang C, Heinecke JW, Davidson WS, Segrest JP. Specialized Cellular Domains for ABCA1-mediated Cholesterol Efflux Detected by Quantitative Electron Microscopy. Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada. 29: 1096-1097. PMID 37613175 DOI: 10.1093/micmic/ozad067.564  0.135
2009 Gharib SA, Vaisar T, Aitken ML, Park DR, Heinecke JW, Fu X. Mapping the lung proteome in cystic fibrosis. Journal of Proteome Research. 8: 3020-8. PMID 19354268 DOI: 10.1021/pr900093j  0.135
2022 Segrest JP, Tang C, Song HD, Jones MK, Davidson WS, Aller SG, Heinecke JW. ABCA1 is an extracellular phospholipid translocase. Nature Communications. 13: 4812. PMID 35974019 DOI: 10.1038/s41467-022-32437-3  0.133
2003 Byun J, Henderson JP, Heinecke JW. Identification and quantification of mutagenic halogenated cytosines by gas chromatography, fast atom bombardment, and electrospray ionization tandem mass spectrometry. Analytical Biochemistry. 317: 201-9. PMID 12758258 DOI: 10.1016/S0003-2697(03)00093-9  0.128
2024 Costacou T, Miller RG, Bornfeldt KE, Heinecke JW, Orchard TJ, Vaisar T. Sex differences in the associations of HDL particle concentration and cholesterol efflux capacity with incident coronary artery disease in type 1 diabetes: The RETRO HDLc cohort study. Journal of Clinical Lipidology. PMID 38320926 DOI: 10.1016/j.jacl.2024.01.004  0.127
1990 Heinecke JW, Meier KE, Lorenzen JA, Shapiro BM. Protein kinase C regulates hydrogen peroxide generation by the respiratory burst oxidase of fertilization Free Radical Biology and Medicine. 9: 107. DOI: 10.1016/0891-5849(90)90555-W  0.126
2019 Vaisar T, Kanter JE, Wimberger J, Irwin AD, Gauthier J, Wolfson E, Bahnam V, Wu IH, Shah H, Keenan HA, Greenbaum CJ, King GL, Heinecke JW, Bornfeldt KE. High Concentration of Medium-Sized HDL Particles and Enrichment in HDL Paraoxonase 1 Associate With Protection From Vascular Complications in People With Long-standing Type 1 Diabetes. Diabetes Care. PMID 31597668 DOI: 10.2337/Dc19-0772  0.122
2024 Shao B, Shimizu-Albergine M, Kramer F, Kanter JE, Heinecke JW, Vaisar T, Mittendorfer B, Patterson BW, Bornfeldt KE. A targeted proteomics method for quantifying plasma apolipoprotein kinetics in individual mice using stable isotope labeling. Journal of Lipid Research. 100531. PMID 38490635 DOI: 10.1016/j.jlr.2024.100531  0.12
2005 Vaisar T, Heinecke JW, Seymour JL, Turecek F. Copper-mediated intra-ligand oxygen transfer in gas-phase complexes with 3-nitrotyrosine. Journal of Mass Spectrometry : Jms. 40: 608-14. PMID 15724273 DOI: 10.1002/Jms.829  0.118
2018 Kothari V, He Y, Kramer F, Barnhart S, Kanter JE, Chait A, Goldberg IJ, Vaisar T, Heinecke JW, Bornfeldt KE. Abstract 390: A New Humanized Mouse Model to Study Lipid Abnormalities and HDL Function in Poorly Controlled Type 1 Diabetes Mellitus Arteriosclerosis, Thrombosis, and Vascular Biology. 38. DOI: 10.1161/atvb.38.suppl_1.390  0.117
2018 Moriarty PM, Vaisar T, Dutton J, Denney LK, Hippe D, Heinecke JW, Zhao X. P5393The change in HDL proteomics following lipid-apheresis therapy European Heart Journal. 39. DOI: 10.1093/eurheartj/ehy566.p5393  0.117
2024 Heinecke JW, Vaisar T, Bornfeldt KE. Does small HDL's function improve when lipid-lowering alters its composition? Journal of Lipid Research. 100505. PMID 38246236 DOI: 10.1016/j.jlr.2024.100505  0.115
2012 Heinecke JW. The not-so-simple HDL story: A new era for quantifying HDL and cardiovascular risk? Nature Medicine. 18: 1346-7. PMID 22961165 DOI: 10.1038/nm.2930  0.114
2012 Keith D, Butler J, Bemer B, Mogle J, Monette J, Hair J, Heinecke J, Sliwinski M, Hagen T. P02.97. Lipoic acid supplementation induces a transient stress response and improves episodic memory and cholesterol efflux in humans Bmc Complementary and Alternative Medicine. 12. DOI: 10.1186/1472-6882-12-S1-P153  0.108
2008 Chang DW, Hayashi S, Gharib SA, Vaisar T, King ST, Tsuchiya M, Ruzinski JT, Park DR, Matute-Bello G, Wurfel MM, Bumgarner R, Heinecke JW, Martin TR. Proteomic and computational analysis of bronchoalveolar proteins during the course of the acute respiratory distress syndrome. American Journal of Respiratory and Critical Care Medicine. 178: 701-9. PMID 18658106 DOI: 10.1164/Rccm.200712-1895Oc  0.105
2002 Deverman BE, Cook BL, Manson SR, Niederhoff RA, Langer EM, Rosová I, Kulans LA, Fu X, Weinberg JS, Heinecke JW, Roth KA, Weintraub SJ. Bcl-xL deamidation is a critical switch in the regulation of the response to DNA damage. Cell. 111: 51-62. PMID 12372300 DOI: 10.1016/S0092-8674(02)00972-8  0.104
2023 Rosenson RS, Cushman M, McKinley EC, Muntner P, Wang Z, Vaisar T, Heinecke J, Tangney C, Judd S, Colantonio LD. Association Between Triglycerides and Incident Cognitive Impairment in Black and White Adults in the Reasons for Geographic and Racial Differences in Stroke Study. Journal of the American Heart Association. e026833. PMID 36802918 DOI: 10.1161/JAHA.122.026833  0.104
2010 Hoofnagle AN, Wu M, Gosmanova AK, Becker JO, Wijsman EM, Brunzell JD, Kahn SE, Knopp RH, Lyons TJ, Heinecke JW. Low clusterin levels in high-density lipoprotein associate with insulin resistance, obesity, and dyslipoproteinemia. Arteriosclerosis, Thrombosis, and Vascular Biology. 30: 2528-34. PMID 20847305 DOI: 10.1161/Atvbaha.110.212894  0.099
2020 Buckner T, Shao B, Eckel RH, Heinecke JW, Bornfeldt KE, Snell-Bergeon J. Association of apolipoprotein C3 with insulin resistance and coronary artery calcium in patients with type 1 diabetes. Journal of Clinical Lipidology. PMID 33257283 DOI: 10.1016/j.jacl.2020.10.006  0.098
2012 Francis GA, Heinecke JW. Advances in high density lipoprotein formation and metabolism: a tribute to John F. Oram (1945-2010). Biochimica Et Biophysica Acta. 1821: 343-4. PMID 22364764 DOI: 10.1016/j.bbalip.2012.02.006  0.098
2009 Posey KA, Clegg DJ, Printz RL, Byun J, Morton GJ, Vivekanandan-Giri A, Pennathur S, Baskin DG, Heinecke JW, Woods SC, Schwartz MW, Niswender KD. Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet. American Journal of Physiology. Endocrinology and Metabolism. 296: E1003-12. PMID 19116375 DOI: 10.1152/Ajpendo.90377.2008  0.096
2006 Chait A, Subramanian S, Han C, Chiba T, Oram J, Heinecke J, Wight T. Mo-W2:1 Diabetes and the vascular wall: Role of inflammatory molecules Atherosclerosis Supplements. 7: 13. DOI: 10.1016/S1567-5688(06)80030-9  0.091
2017 Heinecke JW, Bornfeldt KE. A Long Road Ahead for Discovering New HDL Metrics That Reflect Cardiovascular Disease Risk. Journal of the American College of Cardiology. 70: 179-181. PMID 28683965 DOI: 10.1016/j.jacc.2017.05.038  0.087
2001 Wassef M, Baxter BT, Chisholm RL, Dalman RL, Fillinger MF, Heinecke J, Humphrey JD, Kuivaniemi H, Parks WC, Pearce WH, Platsoucas CD, Sukhova GK, Thompson RW, Tilson MD, Zarins CK. Pathogenesis of abdominal aortic aneurysms: a multidisciplinary research program supported by the National Heart, Lung, and Blood Institute. Journal of Vascular Surgery. 34: 730-8. PMID 11668331 DOI: 10.1067/Mva.2001.116966  0.079
2013 Rosenson RS, Brewer HB, Ansell B, Barter P, Chapman MJ, Heinecke JW, Kontush A, Tall AR, Webb NR. Translation of high-density lipoprotein function into clinical practice: current prospects and future challenges. Circulation. 128: 1256-67. PMID 24019446 DOI: 10.1161/CIRCULATIONAHA.113.000962  0.078
2022 González MF, Burgos-Ravanal R, Shao B, Heinecke J, Valenzuela-Valderrama M, Corvalán AH, Quest AFG. Extracellular vesicles from gastric epithelial GES-1 cells infected with promote changes in recipient cells associated with malignancy. Frontiers in Oncology. 12: 962920. PMID 36313672 DOI: 10.3389/fonc.2022.962920  0.078
2023 Palacios E, Lobos-González L, Guerrero S, Kogan MJ, Shao B, Heinecke JW, Quest AFG, Leyton L, Valenzuela-Valderrama M. Helicobacter pylori outer membrane vesicles induce astrocyte reactivity through nuclear factor-κappa B activation and cause neuronal damage in vivo in a murine model. Journal of Neuroinflammation. 20: 66. PMID 36895046 DOI: 10.1186/s12974-023-02728-7  0.077
2020 Heinecke JW, Parks WC. Integrated Biomarker Discovery and Validation Implicates the Complement Pathway in Early Atherogenesis. Journal of the American College of Cardiology. 75: 1942-1944. PMID 32327105 DOI: 10.1016/j.jacc.2020.03.004  0.076
1999 Henderson JP, Byun J, Heinecke JW. Chlorination of nucleobases, RNA and DNA by myeloperoxidase: a pathway for cytotoxicity and mutagenesis by activated phagocytes. Redox Report : Communications in Free Radical Research. 4: 319-20. PMID 10772075 DOI: 10.1179/135100099101535025  0.066
2023 Heinecke JW, Davidson WS. Size matters: HDL particle populations and the risk of infection. Nature Reviews. Cardiology. PMID 36792718 DOI: 10.1038/s41569-023-00844-8  0.06
1999 Ingbar DH, Bair R, Jung P, Heinecke J, Haddad IY. Hyperoxic lung injury increases HOCl-modified lung proteins and NA,K-adenosine triphosphatase nitrotyrosine content. Chest. 116: 100S. PMID 10424620 DOI: 10.1378/chest.116.suppl_1.100S  0.054
2003 Deverman BE, Cook BL, Manson SR, Niederhoff RA, Langer EM, Rosová I, Kulans LA, Fu X, Weinberg JS, Heinecke JW, Roth KA, Weintraub SJ. Bcl-xL Deamidation Is a Critical Switch in the Regulation of the Response to DNA Damage Cell. 115: 503. DOI: 10.1016/S0092-8674(03)00892-4  0.052
2014 Heinecke JW, Goldberg IJ. Myeloperoxidase: a therapeutic target for preventing insulin resistance and the metabolic sequelae of obesity? Diabetes. 63: 4001-3. PMID 25414015 DOI: 10.2337/db14-1273  0.026
2000 Heinecke JW. Eosinophil-dependent bromination in the pathogenesis of asthma. The Journal of Clinical Investigation. 105: 1331-2. PMID 10811837 DOI: 10.1172/JCI10072  0.026
1985 CORBIN JL, MILLER KF, PARIYADATH N, HEINECKE J, BRUCE AE, WHERLAND S, STIEFEL EI. ChemInform Abstract: SUBSTITUTED CYSTEAMINE LIGANDS AND THEIR COMPLEXES WITH MOLYBDENUM(VI) Chemischer Informationsdienst. 16. DOI: 10.1002/chin.198504260  0.01
1984 Corbin JL, Miller KF, Pariyadath N, Heinecke J, Bruce AE, Wherland S, Stiefel EI. Substituted cysteamine ligands and their complexes with molybdenum(VI) Inorganic Chemistry. 23: 3404-3412. DOI: 10.1002/Chin.198504260  0.01
Hide low-probability matches.