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Curt D. Sigmund - Publications

Affiliations: 
Molecular Physiology & Biophysics University of Iowa, Iowa City, IA 
Area:
Molecular Biology, Physiology Biology, Cell Biology, Genetics
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294 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Sigmund CD. The 2023 Walter B. Cannon Award Lecture: Mechanisms Regulating Vascular Function and Blood Pressure by the PPARγ-RhoBTB1-CUL3 Pathway. Function (Oxford, England). 5: zqad071. PMID 38196837 DOI: 10.1093/function/zqad071  0.303
2023 Ritter ML, Wagner VA, Balapattabi K, Opichka MA, Lu KT, Wackman KK, Reho JJ, Keen HL, Kwitek AE, Morselli LL, Geurts AM, Sigmund CD, Grobe JL. Krüppel-like factor 4 (KLF4) in Transcriptional Control of The Three Unique Isoforms of Agouti-Related Peptide () in Mice. Physiological Genomics. PMID 38145289 DOI: 10.1152/physiolgenomics.00042.2023  0.31
2022 Wu J, Fang S, Lu KT, Kumar G, Reho JJ, Brozoski DT, Otanwa AJ, Hu C, Nair AR, Wackman KK, Agbor LN, Grobe JL, Sigmund CD. Endothelial Cullin3 Mutation Impairs Nitric Oxide-Mediated Vasodilation and Promotes Salt-Induced Hypertension. Function (Oxford, England). 3: zqac017. PMID 35493997 DOI: 10.1093/function/zqac017  0.333
2022 Oliveira V, Riedl RA, Claflin KE, Marin Mathieu N, Ritter ML, Balapattabi K, Wackman KK, Reho JJ, Brozoski DT, Morgan DA, Cui H, Rahmouni K, Burnett CML, Nakagawa P, Sigmund CD, et al. Melanocortin MC4R receptor is required for energy expenditure but not blood pressure effects of angiotensin II within the mouse brain. Physiological Genomics. PMID 35476598 DOI: 10.1152/physiolgenomics.00015.2022  0.599
2022 Fang S, Wu J, Reho JJ, Lu KT, Brozoski DT, Kumar G, Werthman AM, Silva SD, Muskus Veitia PC, Wackman KK, Mathison AJ, Teng BQ, Lin CW, Quelle FW, Sigmund CD. RhoBTB1 reverses established arterial stiffness in angiotensin-II hypertension by promoting actin depolymerization. Jci Insight. PMID 35358093 DOI: 10.1172/jci.insight.158043  0.301
2021 Nakagawa P, Gomez J, Lu KT, Grobe JL, Sigmund CD. Studies of salt and stress sensitivity on arterial pressure in renin-b deficient mice. Plos One. 16: e0250807. PMID 34319999 DOI: 10.1371/journal.pone.0250807  0.312
2021 Fang S, Livergood MC, Nakagawa P, Wu J, Sigmund CD. Role of the Peroxisome Proliferator Activated Receptors in Hypertension. Circulation Research. 128: 1021-1039. PMID 33793338 DOI: 10.1161/CIRCRESAHA.120.318062  0.313
2021 Wu J, Fang S, Lu KT, Wackman K, Schwartzman ML, Dikalov SI, Grobe JL, Sigmund CD. EP3 (E-Prostanoid 3) Receptor Mediates Impaired Vasodilation in a Mouse Model of Salt-Sensitive Hypertension. Hypertension (Dallas, Tex. : 1979). HYPERTENSIONAHA12016. PMID 33641369 DOI: 10.1161/HYPERTENSIONAHA.120.16518  0.341
2020 Wu J, McCormick JA, Sigmund CD. Cullin-3: Renal and Vascular Mechanisms Regulating Blood Pressure. Current Hypertension Reports. 22: 61. PMID 32852625 DOI: 10.1007/S11906-020-01076-8  0.353
2020 Nakagawa P, Nair AR, Agbor LN, Gomez J, Wu J, Zhang SY, Lu KT, Morgan DA, Rahmouni K, Grobe JL, Sigmund CD. Increased Susceptibility of Mice Lacking Renin-b to Angiotensin II-Induced Organ Damage. Hypertension (Dallas, Tex. : 1979). HYPERTENSIONAHA12014. PMID 32507043 DOI: 10.1161/Hypertensionaha.120.14972  0.621
2020 Deng G, Morselli LL, Wagner VA, Balapattabi K, Sapouckey SA, Knudtson KL, Rahmouni K, Cui H, Sigmund CD, Kwitek AE, Grobe JL. Single-Nucleus RNA Sequencing of the Hypothalamic Arcuate Nucleus of C57BL/6J Mice After Prolonged Diet-Induced Obesity. Hypertension (Dallas, Tex. : 1979). HYPERTENSIONAHA12015. PMID 32507042 DOI: 10.1161/Hypertensionaha.120.15137  0.575
2020 Wu J, Agbor LN, Fang S, Mukohda M, Nair AR, Nakagawa P, Sharma A, Morgan DA, Grobe JL, Rahmouni K, Weiss RM, McCormick JA, Sigmund CD. Failure to Vasodilate in Response to Salt Loading Blunts Renal Blood Flow and Causes Salt-Sensitive Hypertension. Cardiovascular Research. PMID 32428209 DOI: 10.1093/Cvr/Cvaa147  0.574
2020 Sapouckey SA, Morselli LL, Deng G, Patil C, Balapattabi K, Oliveira V, Claflin KE, Gomez J, Pearson NA, Potthoff MJ, Gibson-Corley KN, Sigmund CD, Grobe JL. Exploration of cardiometabolic and developmental significance of angiotensinogen expression by cells expressing the leptin receptor or Agouti-related peptide. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. PMID 32186897 DOI: 10.1152/Ajpregu.00297.2019  0.48
2020 Nakagawa P, Gomez J, Grobe JL, Sigmund CD. The Renin-Angiotensin System in the Central Nervous System and Its Role in Blood Pressure Regulation. Current Hypertension Reports. 22: 7. PMID 31925571 DOI: 10.1007/S11906-019-1011-2  0.342
2020 Patil CN, Oliveira V, Opichka M, Ritter ML, Reho JJ, Segar JL, Sigmund CD, Grobe JL. Abstract P239: Diet Modifies Cardiometabolic Effects Of DOCA-salt In C57BL/6J Mice Hypertension. 76. DOI: 10.1161/Hyp.76.Suppl_1.P239  0.319
2020 Fang S, Wu J, Silva SD, Lu K, Sigmund CD. Abstract MP23: Vascular Smooth Muscle Rho-related Btb Domain Containing Protein 1 In Hypertension And Arterial Stiffness Hypertension. 76. DOI: 10.1161/Hyp.76.Suppl_1.Mp23  0.314
2020 Fang S, Wu J, Silva SD, Lu K, Sigmund CD. The Role of Vascular Smooth Muscle RhoBTB1 in Hypertension The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.09221  0.315
2020 Nakagawa P, Nair A, Gomez J, Wu J, Grobe JL, Sigmund CD. Susceptibility of Mice Lacking Renin‐b to Chronic Angiotensin II Infusion The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.06804  0.357
2020 Wu J, Fang S, Hu C, Lu K, Sigmund CD. Endothelial Cullin3 Mutation Causes Vascular Dysfunction, Arterial Stiffening and Hypertension The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.02852  0.315
2020 Balapattabi K, Patil CN, Deng G, Sigmund CD, Grobe JL. CREB and ERK Activation by Leptin and Angiotensin in the GT1‐7 Cell Model by Capillary Electrophoresis‐Based Western Blotting The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.02546  0.333
2020 Oliveira V, Balapattabi K, Patil CN, Hei MV, Silva SD, Reho JJ, Sigmund CD, Grobe JL. Chronic Low‐Dose ICV Infusion of Agrp in Mice May Suppress Indices of Resting Metabolism in Brown Adipose Tissue Independent of Effects on Feeding Behavior The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.02254  0.319
2020 Patil CN, Oliveira V, Balapattabi K, Hei MV, Saravia F, Wackman K, Reho JJ, Kirby JR, Sigmund CD, Grobe JL. Common Laboratory Chow Diets Differentially Affect Energy Homeostasis and Modify Metabolic and Electrolyte Balance Effects of DOCA‐salt in Wildtype Mice The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.02253  0.315
2019 Perschbacher KJ, Deng G, Sandgren JA, Walsh JW, Witcher PC, Sapouckey SA, Owens CE, Zhang SY, Scroggins SM, Pearson NA, Devor EJ, Sebag JA, Pierce GL, Fisher RA, Kwitek AE, ... ... Sigmund CD, et al. Reduced mRNA Expression of RGS2 (Regulator of G Protein Signaling-2) in the Placenta Is Associated With Human Preeclampsia and Sufficient to Cause Features of the Disorder in Mice. Hypertension (Dallas, Tex. : 1979). HYPERTENSIONAHA11914. PMID 31865781 DOI: 10.1161/Hypertensionaha.119.14056  0.408
2019 Fang S, Sigmund CD. PPARγ and RhoBTB1 in hypertension. Current Opinion in Nephrology and Hypertension. PMID 31789920 DOI: 10.1097/Mnh.0000000000000579  0.376
2019 Agbor LN, Nair AR, Wu J, Lu KT, Davis DR, Keen HL, Quelle FW, McCormick JA, Singer JD, Sigmund CD. Conditional deletion of smooth muscle Cullin-3 causes severe progressive hypertension. Jci Insight. 5. PMID 31184598 DOI: 10.1172/Jci.Insight.129793  0.344
2019 Nair AR, Silva SD, Agbor LN, Wu J, Nakagawa P, Mukohda M, Lu KT, Sandgren JA, Pierce GL, Santillan MK, Grobe JL, Sigmund CD. Endothelial PPARγ (Peroxisome Proliferator-Activated Receptor-γ) Protects From Angiotensin II-Induced Endothelial Dysfunction in Adult Offspring Born From Pregnancies Complicated by Hypertension. Hypertension (Dallas, Tex. : 1979). HYPERTENSIONAHA11913. PMID 31104564 DOI: 10.1161/Hypertensionaha.119.13101  0.345
2019 Mukohda M, Fang S, Wu J, Agbor LN, Nair AR, Ibeawuchi SC, Hu C, Liu X, Lu KT, Guo DF, Davis DR, Keen HL, Quelle FW, Sigmund CD. RhoBTB1 protects against hypertension and arterial stiffness by restraining phosphodiesterase 5 activity. The Journal of Clinical Investigation. 130. PMID 30896450 DOI: 10.1172/Jci123462  0.399
2019 Fang S, Mukohda M, Wu J, Nair AR, Liu X, Lu K, Davis DR, Quelle FW, Sigmund CD. Abstract 120: Protective Role of Vascular Smooth Muscle Rho-Related BTB Domain Containing Protein 1 in Hypertension and Arterial Stiffness Hypertension. 74. DOI: 10.1161/Hyp.74.Suppl_1.120  0.323
2019 Nakagawa P, Nair A, Zhang SY, Lu K, Zanaty M, Gomez J, Grobe JL, Sigmund CD. Abstract 098: Susceptibility of Mice Lacking Renin-B to Chronic Angiotensin II Infusion Hypertension. 74. DOI: 10.1161/Hyp.74.Suppl_1.098  0.353
2019 Santillan MK, Santillan DA, Sandgren JA, Pierce GL, Sigmund CD, Grobe JL, Scroggins SM. 105: Regulatory dendritic cell treatment prevents the development of vasopressin-induced preeclampsia in mice American Journal of Obstetrics and Gynecology. 220: S84-S85. DOI: 10.1016/J.Ajog.2018.11.116  0.357
2018 Nair AR, Agbor LN, Mukohda M, Liu X, Hu C, Wu J, Sigmund CD. Interference With Endothelial PPAR (Peroxisome Proliferator-Activated Receptor)-γ Causes Accelerated Cerebral Vascular Dysfunction in Response to Endogenous Renin-Angiotensin System Activation. Hypertension (Dallas, Tex. : 1979). 72: 1227-1235. PMID 30354810 DOI: 10.1161/Hypertensionaha.118.11857  0.444
2018 Sandgren JA, Deng G, Linggonegoro DW, Scroggins SM, Perschbacher KJ, Nair AR, Nishimura TE, Zhang SY, Agbor LN, Wu J, Keen HL, Naber MC, Pearson NA, Zimmerman KA, Weiss RM, ... ... Sigmund CD, et al. Arginine vasopressin infusion is sufficient to model clinical features of preeclampsia in mice. Jci Insight. 3. PMID 30282823 DOI: 10.1172/Jci.Insight.99403  0.427
2018 Cornelius RJ, Zhang C, Erspamer KJ, Agbor LN, Sigmund CD, Singer JD, Yang CL, Ellison DH. Dual gain and loss of cullin 3 function mediates familial hyperkalemic hypertension. American Journal of Physiology. Renal Physiology. PMID 29897280 DOI: 10.1152/Ajprenal.00602.2017  0.321
2018 Forrester SJ, Booz GW, Sigmund CD, Coffman TM, Kawai T, Rizzo V, Scalia R, Eguchi S. Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology. Physiological Reviews. 98: 1627-1738. PMID 29873596 DOI: 10.1152/Physrev.00038.2017  0.331
2018 De Silva TM, Li Y, Kinzenbaw DA, Sigmund CD, Faraci FM. Endothelial PPARγ (Peroxisome Proliferator-Activated Receptor-γ) Is Essential for Preventing Endothelial Dysfunction With Aging. Hypertension (Dallas, Tex. : 1979). PMID 29735632 DOI: 10.1161/Hypertensionaha.117.10799  0.401
2018 Scroggins SM, Santillan DA, Lund JM, Sandgren JA, Krotz LK, Hamilton WS, Devor EJ, Davis HA, Pierce GL, Gibson-Corley KN, Sigmund CD, Grobe JL, Santillan MK. Elevated Vasopressin in Pregnant Mice Induces T Helper Subset Alterations Consistent with Human Preeclampsia. Clinical Science (London, England : 1979). PMID 29371289 DOI: 10.1042/Cs20171059  0.358
2018 Sandgren JA, Linggonegoro DW, Zhang SY, Sapouckey SA, Claflin KE, Pearson NA, Leidinger MR, Pierce GL, Santillan MK, Gibson-Corley KN, Sigmund CD, Grobe JL. Angiotensin AT1A Receptors Expressed in Vasopressin-Producing Cells of the Supraoptic Nucleus Contribute to the Osmotic Control of Vasopressin. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. PMID 29364700 DOI: 10.1152/Ajpregu.00435.2017  0.468
2018 Wu J, Fang S, Hu C, Otanwa AJJ, Nair AR, Agbor LN, Lu K, Mukohda M, Sigmund CD. Abstract P086: Endothelial Cullin3 Mutation Causes Vascular Dysfunction, Arterial Stiffening, And Hypertension Hypertension. 70. DOI: 10.1161/Hyp.76.Suppl_1.P086  0.474
2018 Perschbacher KJ, Deng G, Walsh JW, Santillan DA, Devor EJ, Pierce GL, Sigmund CD, Fisher RA, Gibson-Corley KN, Santillan MK, Grobe JL. Abstract P316: Effects of Paternal Contribution of a Null Allele of Regulator of G Protein Signaling-2 ( Rgs2 ) upon the Placental Transcriptome of C57BL/6J Mice Hypertension. 72. DOI: 10.1161/Hyp.72.Suppl_1.P316  0.348
2018 Gomez JA, Nakagawa P, Sigmund CD. Abstract P204: Induction of Endoplasmic Reticulum Stress Upregulates Renin Expression in Immortalized Mouse Hypothalamic N43/5 Cells Hypertension. 72. DOI: 10.1161/Hyp.72.Suppl_1.P204  0.302
2018 Nakagawa P, Gomez JA, De Azevedo Cruz Seara F, Sigmund CD. Abstract P201: Exposure to Stress and Low Salt Diet Increases Blood Pressure in Mice Lacking the Brain-Specific Renin Isoform Renin-b Hypertension. 72. DOI: 10.1161/Hyp.72.Suppl_1.P201  0.37
2018 Nair AR, Mukohda M, Agbor LN, Lu K, Wu J, Sandgren JA, Grobe JL, Sigmund CD. Abstract 133: Endothelial-Specific Interference With PPARγ Increases the Susceptibility to Angiotensin II-Induced Endothelial Dysfunction in Adult Offspring Born from AVP-Infused Pregnancies Hypertension. 72. DOI: 10.1161/Hyp.72.Suppl_1.133  0.445
2018 Mukohda M, Fang S, Wu J, Agbor LN, Nair AR, Ibeawuchi SC, Hu C, Liu X, Lu K, Guo D, Davis DR, Keen HL, Quelle FW, Sigmund CD. Abstract 110: Vascular Smooth Muscle RhoBTB1 Protects From Hypertension and Arterial Stiffness by Cullin-3 Dependent Ubiquitination of Phosphodiesterase 5 Hypertension. 72. DOI: 10.1161/Hyp.72.Suppl_1.110  0.323
2018 Seara F, Nakagawa P, Gomez JA, Deng G, Sebag JA, Karnik SS, Grobe JL, Sigmund CD. Abstract 104: DOCA Induced Natriorexigenic and Hypertensive Effects are Blunted by Central Infusion of AT1 Receptor Biased Agonist TRV120027 Hypertension. 72. DOI: 10.1161/Hyp.72.Suppl_1.104  0.347
2018 WU J, Agbor LN, Mukohda M, Nair AR, Nakagawa P, Morgan DA, Rahmouni K, Gotlinger KH, Schwartzman ML, Sigmund CD. Abstract 094: Smooth Muscle PPARγ Mutation Causes Impaired Renal Blood Flow and Salt-Sensitive Hypertension Hypertension. 72. DOI: 10.1161/Hyp.72.Suppl_1.094  0.561
2018 Nair AR, Agbor LN, Mukohda M, Liu X, Hu C, Wu J, Sigmund CD. Abstract 036: Interference With PPARγ in the Endothelium Produces Endothelial Dysfunction in the Cerebral Circulation in Response to Activation of the Endogenous Renin-Angiotensin System Hypertension. 72. DOI: 10.1161/Hyp.72.Suppl_1.036  0.335
2017 Peng H, Jensen DD, Li W, Sullivan MN, Buller SA, Worker CJ, Cooper SG, Zheng S, Earley S, Sigmund CD, Feng Y. Overexpression of the Neuronal Human (Pro)renin Receptor Mediates Angiotensin II-Independent Blood Pressure Regulation in the Central Nervous System. American Journal of Physiology. Heart and Circulatory Physiology. PMID 29350998 DOI: 10.1152/Ajpheart.00310.2017  0.453
2017 Ferdaus MZ, Miller LN, Agbor LN, Saritas T, Singer JD, Sigmund CD, McCormick JA. Mutant Cullin 3 causes familial hyperkalemic hypertension via dominant effects. Jci Insight. 2. PMID 29263298 DOI: 10.1172/Jci.Insight.96700  0.394
2017 Sapouckey SA, Deng G, Sigmund CD, Grobe JL. Potential Mechanisms of Hypothalamic Renin-Angiotensin System Activation by Leptin and DOCA-salt for the Control of Resting Metabolism. Physiological Genomics. physiolgenomics.0008. PMID 28986397 DOI: 10.1152/Physiolgenomics.00087.2017  0.403
2017 Shinohara K, Nakagawa P, Gomez J, Morgan DA, Littlejohn NK, Folchert MD, Weidemann BJ, Liu X, Walsh SA, Ponto LL, Rahmouni K, Grobe JL, Sigmund CD. Selective Deletion of Renin-b in the Brain Alters Drinking and Metabolism. Hypertension (Dallas, Tex. : 1979). PMID 28874461 DOI: 10.1161/Hypertensionaha.117.09923  0.616
2017 De Silva TM, Hu C, Kinzenbaw DA, Modrick ML, Sigmund CD, Faraci FM. Genetic Interference With Endothelial Peroxisome Proliferator-Activated Receptor-γ Augments Effects of Angiotensin II While Impairing Responses to Angiotensin 1-7. Hypertension (Dallas, Tex. : 1979). PMID 28674038 DOI: 10.1161/Hypertensionaha.117.09358  0.42
2017 Nakagawa P, Sigmund CD. How Is the Brain Renin-Angiotensin System Regulated? Hypertension (Dallas, Tex. : 1979). 70: 10-18. PMID 28559391 DOI: 10.1161/Hypertensionaha.117.08550  0.391
2017 Mukohda M, Lu KT, Guo DF, Wu J, Keen HL, Liu X, Ketsawatsomkron P, Stump M, Rahmouni K, Quelle FW, Sigmund CD. Hypertension-Causing Mutation in Peroxisome Proliferator-Activated Receptor γ Impairs Nuclear Export of Nuclear Factor-κB p65 in Vascular Smooth Muscle. Hypertension (Dallas, Tex. : 1979). PMID 28507170 DOI: 10.1161/Hypertensionaha.117.09276  0.604
2017 Agassandian K, Grobe JL, Liu X, Agassandian M, Thompson AP, Sigmund CD, Cassell MD. Evidence for Intraventricular Secretion of Angiotensinogen and Angiotensin by the Subfornical Organ Using Transgenic Mice. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. ajpregu.00511.2016. PMID 28490451 DOI: 10.1152/Ajpregu.00511.2016  0.42
2017 Sigmund CD, Diz DI, Chappell MC. No Brain Renin-Angiotensin System: Déjà vu All Over Again? Hypertension (Dallas, Tex. : 1979). PMID 28396531 DOI: 10.1161/Hypertensionaha.117.09167  0.366
2017 Hu C, Keen HL, Lu KT, Liu X, Wu J, Davis DR, Ibeawuchi SC, Vogel S, Quelle FW, Sigmund CD. Retinol-binding protein 7 is an endothelium-specific PPARγ cofactor mediating an antioxidant response through adiponectin. Jci Insight. 2: e91738. PMID 28352663 DOI: 10.1172/Jci.Insight.91738  0.389
2017 Keen HL, Sigmund CD. Microarray Analysis of Hypertension. Methods in Molecular Biology (Clifton, N.J.). 1527: 41-52. PMID 28116705 DOI: 10.1007/978-1-4939-6625-7_3  0.328
2016 Agbor LN, Ibeawuchi SC, Hu C, Wu J, Davis DR, Keen HL, Quelle FW, Sigmund CD. Cullin-3 mutation causes arterial stiffness and hypertension through a vascular smooth muscle mechanism. Jci Insight. 1: e91015. PMID 27882355 DOI: 10.1172/Jci.Insight.91015  0.431
2016 Shinohara K, Liu X, Morgan DA, Davis DR, Sequeira-Lopez ML, Cassell MD, Grobe JL, Rahmouni K, Sigmund CD. Selective Deletion of the Brain-Specific Isoform of Renin Causes Neurogenic Hypertension. Hypertension (Dallas, Tex. : 1979). PMID 27754863 DOI: 10.1161/Hypertensionaha.116.08242  0.66
2016 Prasad AM, Ketsawatsomkron P, Nuno DW, Koval OM, Dibbern ME, Venema AN, Sigmund CD, Lamping KG, Grumbach IM. Role of CaMKII in Ang-II-dependent small artery remodeling. Vascular Pharmacology. PMID 27658984 DOI: 10.1016/J.Vph.2016.09.007  0.373
2016 Stump M, Guo DF, Lu KT, Mukohda M, Cassell MD, Norris AW, Rahmouni K, Sigmund CD. Nervous System Expression of PPARγ and Mutant PPARγ Has Profound Effects on Metabolic Regulation and Brain Development. Endocrinology. en20161524. PMID 27575030 DOI: 10.1210/En.2016-1524  0.613
2016 Littlejohn NK, Keen HL, Weidemann BJ, Claflin KE, Tobin KV, Markan KR, Park S, Naber MC, Gourronc FA, Pearson NA, Liu X, Morgan DA, Klingelhutz AJ, Potthoff MJ, Rahmouni K, ... Sigmund CD, et al. Suppression of Resting Metabolism by the Angiotensin AT2 Receptor. Cell Reports. PMID 27477281 DOI: 10.1016/J.Celrep.2016.07.003  0.616
2016 Song K, Stuart D, Abraham N, Wang F, Wang S, Yang T, Sigmund CD, Kohan DE, Ramkumar N. Collecting Duct Renin Does Not Mediate DOCA-Salt Hypertension or Renal Injury. Plos One. 11: e0159872. PMID 27467376 DOI: 10.1371/Journal.Pone.0159872  0.396
2016 Muta K, Morgan DA, Grobe JL, Sigmund CD, Rahmouni K. mTORC1 Signaling Contributes to Drinking but Not Blood Pressure Responses to Brain Angiotensin II. Endocrinology. en20161243. PMID 27254006 DOI: 10.1210/En.2016-1243  0.599
2016 Stump M, Guo DF, Lu KT, Mukohda M, Liu X, Rahmouni K, Sigmund CD. Effect of Selective Expression of Dominant Negative PPARγ in Proopiomelanocortin Neurons on the Control of Energy Balance. Physiological Genomics. physiolgenomics.0003. PMID 27199455 DOI: 10.1152/Physiolgenomics.00032.2016  0.595
2016 Lu KT, Keen HL, Weatherford ET, Sequeira-Lopez ML, Gomez RA, Sigmund CD. Estrogen Receptor α Is Required for Maintaining Baseline Renin Expression. Hypertension. PMID 26928806 DOI: 10.1161/Hypertensionaha.115.07082  0.776
2016 Muntner P, Becker RC, Calhoun D, Chen D, Cowley AW, Flynn JT, Grobe JL, Kidambi S, Kotchen TA, Lackland DT, Leslie KK, Li Y, Liang M, Lloyd A, Mattson DL, ... ... Sigmund CD, et al. Introduction to the American Heart Association's Hypertension Strategically Focused Research Network. Hypertension. PMID 26902490 DOI: 10.1161/Hypertensionaha.115.06433  0.315
2016 Wu J, Sigmund CD. Hypertension: A Disease That Strikes Around the Clock. Hypertension. 67: 493-5. PMID 26781274 DOI: 10.1161/Hypertensionaha.115.06331  0.327
2016 Chu Y, Lund DD, Doshi H, Keen HL, Knudtson KL, Funk ND, Shao JQ, Cheng J, Hajj GP, Zimmerman KA, Davis MK, Brooks RM, Chapleau MW, Sigmund CD, Weiss RM, et al. Fibrotic Aortic Valve Stenosis in Hypercholesterolemic/Hypertensive Mice. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 26769049 DOI: 10.1161/Atvbaha.115.306912  0.349
2016 Lu KT, Keen HL, Weatherford ET, Sequeira-Lopez MLS, Gomez RA, Sigmund CD. Estrogen Receptor α Is Required for Maintaining Baseline Renin Expression Hypertension. DOI: 10.1161/HYPERTENSIONAHA.115.07082  0.728
2015 Ketsawatsomkron P, Keen HL, Davis DR, Lu KT, Stump M, De Silva TM, Hilzendeger AM, Grobe JL, Faraci FM, Sigmund CD. Protective Role for Tissue Inhibitor of Metalloproteinase-4, a Novel Peroxisome Proliferator-Activated Receptor-γ Target Gene, in Smooth Muscle in Deoxycorticosterone Acetate-Salt Hypertension. Hypertension. PMID 26597823 DOI: 10.1161/Hypertensionaha.115.06391  0.437
2015 Mukohda M, Stump M, Ketsawatsomkron P, Hu C, Quelle FW, Sigmund CD. Endothelial PPARγ Provides Vascular Protection from IL-1β-Induced Oxidative Stress. American Journal of Physiology. Heart and Circulatory Physiology. ajpheart.00490.2015. PMID 26566726 DOI: 10.1152/Ajpheart.00490.2015  0.315
2015 Hu C, Lu KT, Mukohda M, Davis DR, Faraci FM, Sigmund CD. Interference with PPARγ in Endothelium Accelerates Angiotensin II-induced Endothelial Dysfunction. Physiological Genomics. physiolgenomics.0008. PMID 26534936 DOI: 10.1152/Physiolgenomics.00087.2015  0.426
2015 Stump M, Mukohda M, Hu C, Sigmund CD. PPARγ Regulation in Hypertension and Metabolic Syndrome. Current Hypertension Reports. 17: 89. PMID 26462805 DOI: 10.1007/S11906-015-0601-X  0.378
2015 Sequeira-Lopez ML, Nagalakshmi VK, Li M, Sigmund CD, Gomez RA. Vascular versus tubular renin: role in kidney development. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 309: R650-7. PMID 26246508 DOI: 10.1152/Ajpregu.00313.2015  0.409
2015 Ibeawuchi SR, Agbor LN, Quelle FW, Sigmund CD. Hypertension-causing Mutations in Cullin3 Protein Impair RhoA Protein Ubiquitination and Augment the Association with Substrate Adaptors. The Journal of Biological Chemistry. 290: 19208-17. PMID 26100637 DOI: 10.1074/Jbc.M115.645358  0.351
2015 Prasad AM, Morgan DA, Nuno DW, Ketsawatsomkron P, Bair TB, Venema AN, Dibbern ME, Kutschke WJ, Weiss RM, Lamping KG, Chapleau MW, Sigmund CD, Rahmouni K, Grumbach IM. Calcium/Calmodulin-Dependent Kinase II Inhibition in Smooth Muscle Reduces Angiotensin II-Induced Hypertension by Controlling Aortic Remodeling and Baroreceptor Function. Journal of the American Heart Association. 4. PMID 26077587 DOI: 10.1161/Jaha.115.001949  0.567
2015 Hasan DM, Starke RM, Gu H, Wilson K, Chu Y, Chalouhi N, Heistad DD, Faraci FM, Sigmund CD. Smooth Muscle Peroxisome Proliferator-Activated Receptor γ Plays a Critical Role in Formation and Rupture of Cerebral Aneurysms in Mice In Vivo. Hypertension. 66: 211-20. PMID 25916724 DOI: 10.1161/Hypertensionaha.115.05332  0.393
2015 Jo F, Jo H, Hilzendeger AM, Thompson AP, Cassell MD, Rutkowski DT, Davisson RL, Grobe JL, Sigmund CD. Brain endoplasmic reticulum stress mechanistically distinguishes the saline-intake and hypertensive response to deoxycorticosterone acetate-salt. Hypertension. 65: 1341-8. PMID 25895586 DOI: 10.1161/Hypertensionaha.115.05377  0.354
2015 Sandgren JA, Scroggins SM, Santillan DA, Devor EJ, Gibson-Corley KN, Pierce GL, Sigmund CD, Santillan MK, Grobe JL. Vasopressin: the missing link for preeclampsia? American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 309: R1062-4. PMID 25810383 DOI: 10.1152/Ajpregu.00073.2015  0.305
2015 Jin H, Gebska MA, Blokhin IO, Wilson KM, Ketsawatsomkron P, Chauhan AK, Keen HL, Sigmund CD, Lentz SR. Endothelial PPAR-γ protects against vascular thrombosis by downregulating P-selectin expression. Arteriosclerosis, Thrombosis, and Vascular Biology. 35: 838-44. PMID 25675995 DOI: 10.1161/Atvbaha.115.305378  0.377
2015 Santillan MK, Pelham CJ, Ketsawatsomkron P, Santillan DA, Davis DR, Devor EJ, Gibson-Corley KN, Scroggins SM, Grobe JL, Yang B, Hunter SK, Sigmund CD. Pregnant mice lacking indoleamine 2,3-dioxygenase exhibit preeclampsia phenotypes. Physiological Reports. 3. PMID 25602015 DOI: 10.14814/Phy2.12257  0.769
2015 Ketsawatsomkron P, Sigmund CD. Molecular mechanisms regulating vascular tone by peroxisome proliferator activated receptor gamma. Current Opinion in Nephrology and Hypertension. 24: 123-30. PMID 25587903 DOI: 10.1097/Mnh.0000000000000103  0.367
2015 Coble JP, Grobe JL, Johnson AK, Sigmund CD. Mechanisms of brain renin angiotensin system-induced drinking and blood pressure: importance of the subfornical organ. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 308: R238-49. PMID 25519738 DOI: 10.1152/Ajpregu.00486.2014  0.365
2015 Sequeira-Lopez ML, Lin EE, Li M, Hu Y, Sigmund CD, Gomez RA. The earliest metanephric arteriolar progenitors and their role in kidney vascular development. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 308: R138-49. PMID 25427768 DOI: 10.1152/Ajpregu.00428.2014  0.338
2015 De Silva TM, Ketsawatsomkron P, Pelham C, Sigmund CD, Faraci FM. Genetic interference with peroxisome proliferator-activated receptor γ in smooth muscle enhances myogenic tone in the cerebrovasculature via A Rho kinase-dependent mechanism. Hypertension. 65: 345-51. PMID 25385762 DOI: 10.1161/Hypertensionaha.114.04541  0.773
2014 Grobe JL, Sigmund CD. Another reason to eat your greens: cardiopulmonary protection by dietary delivery of angiotensin-converting enzyme-2 and angiotensin-(1-7) made in plants. Hypertension. 64: 1182-3. PMID 25225201 DOI: 10.1161/Hypertensionaha.114.04075  0.349
2014 De Silva TM, Modrick ML, Ketsawatsomkron P, Lynch C, Chu Y, Pelham CJ, Sigmund CD, Faraci FM. Role of peroxisome proliferator-activated receptor-γ in vascular muscle in the cerebral circulation. Hypertension. 64: 1088-93. PMID 25185134 DOI: 10.1161/Hypertensionaha.114.03935  0.773
2014 Ramkumar N, Stuart D, Rees S, Hoek AV, Sigmund CD, Kohan DE. Collecting duct-specific knockout of renin attenuates angiotensin II-induced hypertension. American Journal of Physiology. Renal Physiology. 307: F931-8. PMID 25122048 DOI: 10.1152/Ajprenal.00367.2014  0.43
2014 Carrillo-Sepulveda MA, Keen HL, Davis DR, Grobe JL, Sigmund CD. Role of vascular smooth muscle PPARγ in regulating AT1 receptor signaling and angiotensin II-dependent hypertension. Plos One. 9: e103786. PMID 25122005 DOI: 10.1371/Journal.Pone.0103786  0.449
2014 Coble JP, Cassell MD, Davis DR, Grobe JL, Sigmund CD. Activation of the renin-angiotensin system, specifically in the subfornical organ is sufficient to induce fluid intake. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 307: R376-86. PMID 24965793 DOI: 10.1152/Ajpregu.00216.2014  0.405
2014 Borges GR, Morgan DA, Ketsawatsomkron P, Mickle AD, Thompson AP, Cassell MD, Mohapatra DP, Rahmouni K, Sigmund CD. Interference with peroxisome proliferator-activated receptor-γ in vascular smooth muscle causes baroreflex impairment and autonomic dysfunction. Hypertension. 64: 590-6. PMID 24914194 DOI: 10.1161/Hypertensionaha.114.03553  0.637
2014 Coble JP, Johnson RF, Cassell MD, Johnson AK, Grobe JL, Sigmund CD. Activity of protein kinase C-α within the subfornical organ is necessary for fluid intake in response to brain angiotensin. Hypertension. 64: 141-8. PMID 24777977 DOI: 10.1161/Hypertensionaha.114.03461  0.363
2013 Park S, Lu KT, Liu X, Chatterjee TK, Rudich SM, Weintraub NL, Kwitek AE, Sigmund CD. Allele-specific expression of angiotensinogen in human subcutaneous adipose tissue. Hypertension. 62: 41-7. PMID 23648704 DOI: 10.1161/Hypertensionaha.113.01330  0.336
2013 Littlejohn NK, Siel RB, Ketsawatsomkron P, Pelham CJ, Pearson NA, Hilzendeger AM, Buehrer BA, Weidemann BJ, Li H, Davis DR, Thompson AP, Liu X, Cassell MD, Sigmund CD, Grobe JL. Hypertension in mice with transgenic activation of the brain renin-angiotensin system is vasopressin dependent. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 304: R818-28. PMID 23535460 DOI: 10.1152/Ajpregu.00082.2013  0.791
2013 Sigmund CD. A clinical link between peroxisome proliferator-activated receptor γ and the renin-angiotensin system. Arteriosclerosis, Thrombosis, and Vascular Biology. 33: 676-8. PMID 23486770 DOI: 10.1161/Atvbaha.112.301125  0.433
2013 Pelham CJ, Keen HL, Lentz SR, Sigmund CD. Dominant negative PPARγ promotes atherosclerosis, vascular dysfunction, and hypertension through distinct effects in endothelium and vascular muscle. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 304: R690-701. PMID 23447133 DOI: 10.1152/Ajpregu.00607.2012  0.775
2013 Quelle FW, Sigmund CD. PPARγ: no SirT, no service. Circulation Research. 112: 411-4. PMID 23371897 DOI: 10.1161/Circresaha.113.300870  0.373
2013 Chu Y, Lund DD, Weiss RM, Brooks RM, Doshi H, Hajj GP, Sigmund CD, Heistad DD. Pioglitazone attenuates valvular calcification induced by hypercholesterolemia. Arteriosclerosis, Thrombosis, and Vascular Biology. 33: 523-32. PMID 23288158 DOI: 10.1161/Atvbaha.112.300794  0.324
2013 Hilzendeger AM, Cassell MD, Davis DR, Stauss HM, Mark AL, Grobe JL, Sigmund CD. Angiotensin type 1a receptors in the subfornical organ are required for deoxycorticosterone acetate-salt hypertension. Hypertension. 61: 716-22. PMID 23266541 DOI: 10.1161/Hypertensionaha.111.00356  0.33
2013 Grobe JL, Rahmouni K, Liu X, Sigmund CD. Metabolic rate regulation by the renin-angiotensin system: brain vs. body. PflüGers Archiv : European Journal of Physiology. 465: 167-75. PMID 22491893 DOI: 10.1007/S00424-012-1096-9  0.549
2012 Cai J, Keen HL, Sigmund CD, Casavant TL. Coex-Rank: An approach incorporating co-expression information for combined analysis of microarray data. Journal of Integrative Bioinformatics. 9: 32-43. PMID 29220886 DOI: 10.1515/jib-2012-208  0.505
2012 Pelham CJ, Ketsawatsomkron P, Groh S, Grobe JL, de Lange WJ, Ibeawuchi SR, Keen HL, Weatherford ET, Faraci FM, Sigmund CD. Cullin-3 regulates vascular smooth muscle function and arterial blood pressure via PPARγ and RhoA/Rho-kinase. Cell Metabolism. 16: 462-72. PMID 23040068 DOI: 10.1016/J.Cmet.2012.08.011  0.808
2012 Ketsawatsomkron P, Lorca RA, Keen HL, Weatherford ET, Liu X, Pelham CJ, Grobe JL, Faraci FM, England SK, Sigmund CD. PPARγ regulates resistance vessel tone through a mechanism involving RGS5-mediated control of protein kinase C and BKCa channel activity. Circulation Research. 111: 1446-58. PMID 22962432 DOI: 10.1161/Circresaha.112.271577  0.791
2012 Cai J, Keen HL, Sigmund CD, Casavant TL. Coex-Rank: An approach incorporating co-expression information for combined analysis of microarray data. Journal of Integrative Bioinformatics. 9: 208. PMID 22842118 DOI: 10.2390/Biecoll-Jib-2012-208  0.554
2012 Lin LH, Nitschke Dragon D, Jin J, Tian X, Chu Y, Sigmund C, Talman WT. Decreased expression of neuronal nitric oxide synthase in the nucleus tractus solitarii inhibits sympathetically mediated baroreflex responses in rat. The Journal of Physiology. 590: 3545-59. PMID 22687614 DOI: 10.1113/Jphysiol.2012.237966  0.324
2012 Hilzendeger AM, Morgan DA, Brooks L, Dellsperger D, Liu X, Grobe JL, Rahmouni K, Sigmund CD, Mark AL. A brain leptin-renin angiotensin system interaction in the regulation of sympathetic nerve activity. American Journal of Physiology. Heart and Circulatory Physiology. 303: H197-206. PMID 22610169 DOI: 10.1152/Ajpheart.00974.2011  0.596
2012 Park S, Liu X, Davis DR, Sigmund CD. Gene trapping uncovers sex-specific mechanisms for upstream stimulatory factors 1 and 2 in angiotensinogen expression. Hypertension. 59: 1212-9. PMID 22547438 DOI: 10.1161/Hypertensionaha.112.192971  0.445
2012 Modrick ML, Kinzenbaw DA, Chu Y, Sigmund CD, Faraci FM. Peroxisome proliferator-activated receptor-γ protects against vascular aging. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 302: R1184-90. PMID 22461176 DOI: 10.1152/Ajpregu.00557.2011  0.405
2012 Weatherford ET, Liu X, Sigmund CD. Regulation of renin expression by the orphan nuclear receptors Nr2f2 and Nr2f6. American Journal of Physiology. Renal Physiology. 302: F1025-33. PMID 22278040 DOI: 10.1152/Ajprenal.00362.2011  0.774
2012 Sigmund CD. Divergent mechanism regulating fluid intake and metabolism by the brain renin-angiotensin system. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 302: R313-20. PMID 22049229 DOI: 10.1152/Ajpregu.00575.2011  0.388
2012 Sigmund CD, Fabian JR, Gross KW. Expression and regulation of the renin gene. Trends in Cardiovascular Medicine. 2: 237-45. PMID 21239248 DOI: 10.1016/1050-1738(92)90031-M  0.435
2011 He BJ, Joiner ML, Singh MV, Luczak ED, Swaminathan PD, Koval OM, Kutschke W, Allamargot C, Yang J, Guan X, Zimmerman K, Grumbach IM, Weiss RM, Spitz DR, Sigmund CD, et al. Oxidation of CaMKII determines the cardiotoxic effects of aldosterone. Nature Medicine. 17: 1610-8. PMID 22081025 DOI: 10.1038/Nm.2506  0.301
2011 Li H, Weatherford ET, Davis DR, Keen HL, Grobe JL, Daugherty A, Cassis LA, Allen AM, Sigmund CD. Renal proximal tubule angiotensin AT1A receptors regulate blood pressure. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 301: R1067-77. PMID 21753145 DOI: 10.1152/Ajpregu.00124.2011  0.786
2011 Rahmouni K, Davisson RL, Sigmund CD. Inflaming hypothalamic neurons raises blood pressure. Cell Metabolism. 14: 3-4. PMID 21723497 DOI: 10.1016/J.Cmet.2011.06.006  0.552
2011 Harlan SM, Morgan DA, Agassandian K, Guo DF, Cassell MD, Sigmund CD, Mark AL, Rahmouni K. Ablation of the leptin receptor in the hypothalamic arcuate nucleus abrogates leptin-induced sympathetic activation. Circulation Research. 108: 808-12. PMID 21311043 DOI: 10.1161/Circresaha.111.240226  0.618
2011 Ostedgaard LS, Meyerholz DK, Vermeer DW, Karp PH, Schneider L, Sigmund CD, Welsh MJ. Cystic fibrosis transmembrane conductance regulator with a shortened R domain rescues the intestinal phenotype of CFTR-/- mice. Proceedings of the National Academy of Sciences of the United States of America. 108: 2921-6. PMID 21285372 DOI: 10.1073/Pnas.1019752108  0.301
2011 Grobe JL, Buehrer BA, Hilzendeger AM, Liu X, Davis DR, Xu D, Sigmund CD. Angiotensinergic signaling in the brain mediates metabolic effects of deoxycorticosterone (DOCA)-salt in C57 mice. Hypertension. 57: 600-7. PMID 21263123 DOI: 10.1161/Hypertensionaha.110.165829  0.404
2011 Xu D, Borges GR, Davis DR, Agassandian K, Sequeira Lopez ML, Gomez RA, Cassell MD, Grobe JL, Sigmund CD. Neuron- or glial-specific ablation of secreted renin does not affect renal renin, baseline arterial pressure, or metabolism. Physiological Genomics. 43: 286-94. PMID 21189370 DOI: 10.1152/Physiolgenomics.00208.2010  0.438
2010 Sigmund CD. Structural biology: On stress and pressure. Nature. 468: 46-7. PMID 21048758 DOI: 10.1038/468046A  0.319
2010 Grobe JL, Grobe CL, Beltz TG, Westphal SG, Morgan DA, Xu D, de Lange WJ, Li H, Sakai K, Thedens DR, Cassis LA, Rahmouni K, Mark AL, Johnson AK, Sigmund CD. The brain Renin-angiotensin system controls divergent efferent mechanisms to regulate fluid and energy balance. Cell Metabolism. 12: 431-42. PMID 21035755 DOI: 10.1016/J.Cmet.2010.09.011  0.595
2010 Grobe JL, Dickson ME, Park S, Davis DR, Born EJ, Sigmund CD. Cardiovascular consequences of genetic variation at -6/235 in human angiotensinogen using "humanized" gene-targeted mice. Hypertension. 56: 981-7. PMID 20823378 DOI: 10.1161/Hypertensionaha.110.157354  0.429
2010 Redding KM, Chen BL, Singh A, Re RN, Navar LG, Seth DM, Sigmund CD, Tang WW, Cook JL. Transgenic mice expressing an intracellular fluorescent fusion of angiotensin II demonstrate renal thrombotic microangiopathy and elevated blood pressure. American Journal of Physiology. Heart and Circulatory Physiology. 298: H1807-18. PMID 20363893 DOI: 10.1152/Ajpheart.00027.2010  0.467
2010 Ketsawatsomkron P, Pelham CJ, Groh S, Keen HL, Faraci FM, Sigmund CD. Does peroxisome proliferator-activated receptor-gamma (PPAR gamma) protect from hypertension directly through effects in the vasculature? The Journal of Biological Chemistry. 285: 9311-6. PMID 20129921 DOI: 10.1074/Jbc.R109.025031  0.771
2010 Desch M, Schreiber A, Schweda F, Madsen K, Friis UG, Weatherford ET, Sigmund CD, Sequeira Lopez ML, Gomez RA, Todorov VT. Increased renin production in mice with deletion of peroxisome proliferator-activated receptor-gamma in juxtaglomerular cells. Hypertension. 55: 660-6. PMID 20065157 DOI: 10.1161/Hypertensionaha.109.138800  0.813
2010 Sequeira-Lopez ML, Weatherford ET, Borges GR, Monteagudo MC, Pentz ES, Harfe BD, Carretero O, Sigmund CD, Gomez RA. The microRNA-processing enzyme dicer maintains juxtaglomerular cells. Journal of the American Society of Nephrology : Jasn. 21: 460-7. PMID 20056748 DOI: 10.1681/Asn.2009090964  0.759
2010 Sigmund CD. Endothelial and vascular muscle PPARgamma in arterial pressure regulation: lessons from genetic interference and deficiency. Hypertension. 55: 437-44. PMID 20038751 DOI: 10.1161/Hypertensionaha.109.144170  0.435
2010 Keen HL, Halabi CM, Beyer AM, de Lange WJ, Liu X, Maeda N, Faraci FM, Casavant TL, Sigmund CD. Bioinformatic analysis of gene sets regulated by ligand-activated and dominant-negative peroxisome proliferator-activated receptor gamma in mouse aorta. Arteriosclerosis, Thrombosis, and Vascular Biology. 30: 518-25. PMID 20018933 DOI: 10.1161/Atvbaha.109.200733  0.789
2010 Feng Y, Xia H, Cai Y, Halabi CM, Becker LK, Santos RA, Speth RC, Sigmund CD, Lazartigues E. Brain-selective overexpression of human Angiotensin-converting enzyme type 2 attenuates neurogenic hypertension. Circulation Research. 106: 373-82. PMID 19926873 DOI: 10.1161/Circresaha.109.208645  0.705
2009 Xu D, Borges GR, Grobe JL, Pelham CJ, Yang B, Sigmund CD. Preservation of intracellular renin expression is insufficient to compensate for genetic loss of secreted renin. Hypertension. 54: 1240-7. PMID 19822797 DOI: 10.1161/Hypertensionaha.109.138677  0.774
2009 Chen S, Li G, Zhang W, Wang J, Sigmund CD, Olson JE, Chen Y. Ischemia-induced brain damage is enhanced in human renin and angiotensinogen double-transgenic mice. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 297: R1526-31. PMID 19759335 DOI: 10.1152/Ajpregu.91040.2008  0.331
2009 Bianco RA, Agassandian K, Cassell MD, Spector AA, Sigmund CD. Characterization of transgenic mice with neuron-specific expression of soluble epoxide hydrolase. Brain Research. 1291: 60-72. PMID 19643090 DOI: 10.1016/J.Brainres.2009.07.060  0.41
2009 Itani H, Liu X, Sarsour EH, Goswami PC, Born E, Keen HL, Sigmund CD. Regulation of renin gene expression by oxidative stress. Hypertension. 53: 1070-6. PMID 19433777 DOI: 10.1161/Hypertensionaha.109.130633  0.697
2009 Modrick ML, Didion SP, Sigmund CD, Faraci FM. Role of oxidative stress and AT1 receptors in cerebral vascular dysfunction with aging. American Journal of Physiology. Heart and Circulatory Physiology. 296: H1914-9. PMID 19395552 DOI: 10.1152/Ajpheart.00300.2009  0.411
2009 Grobe JL, Venegas-Pont M, Sigmund CD, Ryan MJ. PPARgamma differentially regulates energy substrate handling in brown vs. white adipose: focus on "The PPARgamma agonist rosiglitazone enhances rat brown adipose tissue lipogenesis from glucose without altering glucose uptake". American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 296: R1325-6. PMID 19261916 DOI: 10.1152/Ajpregu.00123.2009  0.319
2009 Rahmouni K, Sigmund CD, Haynes WG, Mark AL. Hypothalamic ERK mediates the anorectic and thermogenic sympathetic effects of leptin. Diabetes. 58: 536-42. PMID 19066310 DOI: 10.2337/Db08-0822  0.572
2009 Santillan M, Pelham C, Ketsawatsomkron P, Santillan D, Yang B, Hunter S, Sigmund C. 766: Development and characterization of an indoleamine 2,3-dioxygenase (IDO) deficient mouse model of preeclampsia American Journal of Obstetrics and Gynecology. 201: S276. DOI: 10.1016/J.Ajog.2009.10.783  0.723
2008 Sigmund CD. A growing chain of evidence linking genetic variation in angiotensinogen with essential hypertension: focus on "a haplotype of human angiotensinogen gene containing -217A increases blood pressure in transgenic mice compared with -217G," by Jain et al. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 295: R1846-8. PMID 18971347 DOI: 10.1152/Ajpregu.90856.2008  0.382
2008 Harlan SM, Reiter RS, Sigmund CD, Lin JL, Lin JJ. Requirement of TCTG(G/C) Direct Repeats and Overlapping GATA Site for Maintaining the Cardiac-Specific Expression of Cardiac troponin T in Developing and Adult Mice. Anatomical Record (Hoboken, N.J. : 2007). 291: 1574-86. PMID 18951515 DOI: 10.1002/Ar.20772  0.372
2008 Dickson ME, Tian X, Liu X, Davis DR, Sigmund CD. Upstream stimulatory factor is required for human angiotensinogen expression and differential regulation by the A-20C polymorphism. Circulation Research. 103: 940-7. PMID 18802024 DOI: 10.1161/Circresaha.108.180653  0.377
2008 Rahmouni K, Sigmund CD. Id3, E47, and SREBP-1c: fat factors controlling adiponectin expression. Circulation Research. 103: 565-7. PMID 18796641 DOI: 10.1161/Circresaha.108.184366  0.578
2008 Beyer AM, de Lange WJ, Halabi CM, Modrick ML, Keen HL, Faraci FM, Sigmund CD. Endothelium-specific interference with peroxisome proliferator activated receptor gamma causes cerebral vascular dysfunction in response to a high-fat diet. Circulation Research. 103: 654-61. PMID 18676352 DOI: 10.1161/Circresaha.108.176339  0.802
2008 Zhou X, Weatherford ET, Liu X, Born E, Keen HL, Sigmund CD. Dysregulated human renin expression in transgenic mice carrying truncated genomic constructs: evidence supporting the presence of insulators at the renin locus. American Journal of Physiology. Renal Physiology. 295: F642-53. PMID 18632798 DOI: 10.1152/Ajprenal.00384.2007  0.81
2008 de Lange WJ, Halabi CM, Beyer AM, Sigmund CD. Germ line activation of the Tie2 and SMMHC promoters causes noncell-specific deletion of floxed alleles. Physiological Genomics. 35: 1-4. PMID 18612081 DOI: 10.1152/Physiolgenomics.90284.2008  0.775
2008 Shi PP, Cao XR, Sweezer EM, Kinney TS, Williams NR, Husted RF, Nair R, Weiss RM, Williamson RA, Sigmund CD, Snyder PM, Staub O, Stokes JB, Yang B. Salt-sensitive hypertension and cardiac hypertrophy in mice deficient in the ubiquitin ligase Nedd4-2. American Journal of Physiology. Renal Physiology. 295: F462-70. PMID 18524855 DOI: 10.1152/Ajprenal.90300.2008  0.443
2008 Li H, Zhou X, Davis DR, Xu D, Sigmund CD. An androgen-inducible proximal tubule-specific Cre recombinase transgenic model. American Journal of Physiology. Renal Physiology. 294: F1481-6. PMID 18385272 DOI: 10.1152/Ajprenal.00064.2008  0.632
2008 Halabi CM, Beyer AM, de Lange WJ, Keen HL, Baumbach GL, Faraci FM, Sigmund CD. Interference with PPAR gamma function in smooth muscle causes vascular dysfunction and hypertension. Cell Metabolism. 7: 215-26. PMID 18316027 DOI: 10.1016/J.Cmet.2007.12.008  0.793
2008 Wakisaka Y, Miller JD, Chu Y, Baumbach GL, Wilson S, Faraci FM, Sigmund CD, Heistad DD. Oxidative stress through activation of NAD(P)H oxidase in hypertensive mice with spontaneous intracranial hemorrhage. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 28: 1175-85. PMID 18301433 DOI: 10.1038/Jcbfm.2008.7  0.368
2008 Beyer AM, Baumbach GL, Halabi CM, Modrick ML, Lynch CM, Gerhold TD, Ghoneim SM, de Lange WJ, Keen HL, Tsai YS, Maeda N, Sigmund CD, Faraci FM. Interference with PPARgamma signaling causes cerebral vascular dysfunction, hypertrophy, and remodeling. Hypertension. 51: 867-71. PMID 18285614 DOI: 10.1161/Hypertensionaha.107.103648  0.786
2008 Zhou X, Sigmund CD. Chorionic enhancer is dispensable for regulated expression of the human renin gene. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 294: R279-87. PMID 18077515 DOI: 10.1152/Ajpregu.00780.2007  0.642
2008 Beyer AM, Baumbach GL, Halabi CM, Modrick ML, Lynch CM, Gerhold TD, Ghoneim SM, De Lange WJ, Keen HL, Tsai YS, Maeda N, Sigmund CD, Faraci FM. Interference with PPARγ signaling causes cerebral vascular dysfunction, hypertrophy, and remodeling (Hypertension (2008) 51, (867-871)) Hypertension. 51: e33. DOI: 10.1161/Hypertensionaha.108.009862  0.702
2007 Weatherford ET, Itani H, Keen HL, Sigmund CD. Is peroxisome proliferator-activated receptor-gamma a new "pal" of renin? Hypertension. 50: 844-6. PMID 17785627 DOI: 10.1161/Hypertensionaha.107.097519  0.757
2007 Kobori H, Ozawa Y, Satou R, Katsurada A, Miyata K, Ohashi N, Hase N, Suzaki Y, Sigmund CD, Navar LG. Kidney-specific enhancement of ANG II stimulates endogenous intrarenal angiotensinogen in gene-targeted mice. American Journal of Physiology. Renal Physiology. 293: F938-45. PMID 17634399 DOI: 10.1152/Ajprenal.00146.2007  0.415
2007 Sakai K, Agassandian K, Morimoto S, Sinnayah P, Cassell MD, Davisson RL, Sigmund CD. Local production of angiotensin II in the subfornical organ causes elevated drinking. The Journal of Clinical Investigation. 117: 1088-95. PMID 17404622 DOI: 10.1172/Jci31242  0.435
2007 Driskell RR, Goodheart M, Neff T, Liu X, Luo M, Moothart C, Sigmund CD, Hosokawa R, Chai Y, Engelhardt JF. Wnt3a regulates Lef-1 expression during airway submucosal gland morphogenesis. Developmental Biology. 305: 90-102. PMID 17335794 DOI: 10.1016/J.Ydbio.2007.01.038  0.421
2007 Dickson ME, Zimmerman MB, Rahmouni K, Sigmund CD. The -20 and -217 promoter variants dominate differential angiotensinogen haplotype regulation in angiotensinogen-expressing cells. Hypertension. 49: 631-9. PMID 17200439 DOI: 10.1161/01.Hyp.0000254350.62876.B1  0.578
2007 Itani HA, Liu X, Pratt JH, Sigmund CD. Functional characterization of polymorphisms in the kidney enhancer of the human renin gene. Endocrinology. 148: 1424-30. PMID 17158202 DOI: 10.1210/En.2006-1381  0.699
2007 McCray PB, Pewe L, Wohlford-Lenane C, Hickey M, Manzel L, Shi L, Netland J, Jia HP, Halabi C, Sigmund CD, Meyerholz DK, Kirby P, Look DC, Perlman S. Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus. Journal of Virology. 81: 813-21. PMID 17079315 DOI: 10.1128/Jvi.02012-06  0.687
2006 Sinnayah P, Lazartigues E, Sakai K, Sharma RV, Sigmund CD, Davisson RL. Genetic ablation of angiotensinogen in the subfornical organ of the brain prevents the central angiotensinergic pressor response. Circulation Research. 99: 1125-31. PMID 17053195 DOI: 10.1161/01.Res.0000250259.66683.F5  0.43
2006 Zhou X, Davis DR, Sigmund CD. The human renin kidney enhancer is required to maintain base-line renin expression but is dispensable for tissue-specific, cell-specific, and regulated expression. The Journal of Biological Chemistry. 281: 35296-304. PMID 16990260 DOI: 10.1074/Jbc.M608055200  0.653
2006 Liu X, Shi Q, Sigmund CD. Interleukin-1beta attenuates renin gene expression via a mitogen-activated protein kinase kinase-extracellular signal-regulated kinase and signal transducer and activator of transcription 3-dependent mechanism in As4.1 cells. Endocrinology. 147: 6011-8. PMID 16959849 DOI: 10.1210/En.2006-0129  0.426
2006 Dickson ME, Sigmund CD. Genetic basis of hypertension: revisiting angiotensinogen. Hypertension. 48: 14-20. PMID 16754793 DOI: 10.1161/01.Hyp.0000227932.13687.60  0.327
2006 Brand M, Lamandé N, Sigmund CD, Larger E, Corvol P, Gasc JM. Angiotensinogen modulates renal vasculature growth. Hypertension. 47: 1067-74. PMID 16636191 DOI: 10.1161/01.Hyp.0000221065.05670.23  0.423
2006 Cao XR, Shi PP, Sigmund RD, Husted RF, Sigmund CD, Williamson RA, Stokes JB, Yang B. Mice heterozygous for beta-ENaC deletion have defective potassium excretion. American Journal of Physiology. Renal Physiology. 291: F107-15. PMID 16571596 DOI: 10.1152/Ajprenal.00159.2005  0.346
2006 Sachetelli S, Liu Q, Zhang SL, Liu F, Hsieh TJ, Brezniceanu ML, Guo DF, Filep JG, Ingelfinger JR, Sigmund CD, Hamet P, Chan JS. RAS blockade decreases blood pressure and proteinuria in transgenic mice overexpressing rat angiotensinogen gene in the kidney. Kidney International. 69: 1016-23. PMID 16528251 DOI: 10.1038/Sj.Ki.5000210  0.434
2006 Sethi S, Iida S, Sigmund CD, Heistad DD. Renal thrombotic microangiopathy in a genetic model of hypertension in mice. Experimental Biology and Medicine (Maywood, N.J.). 231: 196-203. PMID 16446496 DOI: 10.1177/153537020623100210  0.39
2006 Lavoie JL, Liu X, Bianco RA, Beltz TG, Johnson AK, Sigmund CD. Evidence supporting a functional role for intracellular renin in the brain. Hypertension. 47: 461-6. PMID 16446393 DOI: 10.1161/01.Hyp.0000203308.52919.Dc  0.471
2006 Kiss PJ, Knisz J, Zhang Y, Baltrusaitis J, Sigmund CD, Thalmann R, Smith RJ, Verpy E, Bánfi B. Inactivation of NADPH oxidase organizer 1 results in severe imbalance. Current Biology : Cb. 16: 208-13. PMID 16431374 DOI: 10.1016/J.Cub.2005.12.025  0.304
2006 Sigmund CD, Davisson RL. Targeting brain AT1 receptors by RNA interference. Hypertension. 47: 145-6. PMID 16380514 DOI: 10.1161/01.Hyp.0000200278.64801.4E  0.359
2006 Faraci FM, Lamping KG, Modrick ML, Ryan MJ, Sigmund CD, Didion SP. Cerebral vascular effects of angiotensin II: new insights from genetic models. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 26: 449-55. PMID 16094317 DOI: 10.1038/Sj.Jcbfm.9600204  0.425
2005 Halabi CM, Sigmund CD. Peroxisome proliferator-activated receptor-gamma and its agonists in hypertension and atherosclerosis : mechanisms and clinical implications. American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions. 5: 389-98. PMID 16259527 DOI: 10.2165/00129784-200505060-00006  0.698
2005 Sherrod M, Davis DR, Zhou X, Cassell MD, Sigmund CD. Glial-specific ablation of angiotensinogen lowers arterial pressure in renin and angiotensinogen transgenic mice. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 289: R1763-9. PMID 16109805 DOI: 10.1152/Ajpregu.00435.2005  0.804
2005 Fath MA, Mullins RF, Searby C, Nishimura DY, Wei J, Rahmouni K, Davis RE, Tayeh MK, Andrews M, Yang B, Sigmund CD, Stone EM, Sheffield VC. Mkks-null mice have a phenotype resembling Bardet-Biedl syndrome. Human Molecular Genetics. 14: 1109-18. PMID 15772095 DOI: 10.1093/Hmg/Ddi123  0.661
2005 Sakai K, Sigmund CD. Molecular evidence of tissue renin-angiotensin systems: a focus on the brain. Current Hypertension Reports. 7: 135-40. PMID 15748539 DOI: 10.1007/S11906-005-0088-Y  0.368
2005 Sherrod M, Liu X, Zhang X, Sigmund CD. Nuclear localization of angiotensinogen in astrocytes. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 288: R539-46. PMID 15388495 DOI: 10.1152/Ajpregu.00594.2004  0.772
2004 Sakai K, Chapleau MW, Morimoto S, Cassell MD, Sigmund CD. Differential modulation of baroreflex control of heart rate by neuron- vs. glia-derived angiotensin II. Physiological Genomics. 20: 66-72. PMID 15467015 DOI: 10.1152/Physiolgenomics.00168.2004  0.42
2004 Baumbach GL, Sigmund CD, Faraci FM. Structure of cerebral arterioles in mice deficient in expression of the gene for endothelial nitric oxide synthase. Circulation Research. 95: 822-9. PMID 15388643 DOI: 10.1161/01.Res.0000146279.11923.14  0.429
2004 Rahmouni K, Morgan DA, Morgan GM, Liu X, Sigmund CD, Mark AL, Haynes WG. Hypothalamic PI3K and MAPK differentially mediate regional sympathetic activation to insulin. The Journal of Clinical Investigation. 114: 652-8. PMID 15343383 DOI: 10.1172/Jci21737  0.521
2004 Stunz LL, Busch LK, Munroe ME, Sigmund CD, Tygrett LT, Waldschmidt TJ, Bishop GA. Expression of the cytoplasmic tail of LMP1 in mice induces hyperactivation of B lymphocytes and disordered lymphoid architecture. Immunity. 21: 255-66. PMID 15308105 DOI: 10.1016/J.Immuni.2004.07.008  0.354
2004 Lavoie JL, Bianco RA, Sakai K, Keen HL, Ryan MJ, Sigmund CD. Transgenic mice for studies of the renin-angiotensin system in hypertension Acta Physiologica Scandinavica. 181: 571-577. PMID 15283772 DOI: 10.1111/J.1365-201X.2004.01332.X  0.417
2004 Liu X, Driskell RR, Luo M, Abbott D, Filali M, Cheng N, Sigmund CD, Engelhardt JF. Characterization of Lef-1 promoter segments that facilitate inductive developmental expression in skin. The Journal of Investigative Dermatology. 123: 264-74. PMID 15245424 DOI: 10.1111/J.0022-202X.2004.23201.X  0.376
2004 Driskell RR, Liu X, Luo M, Filali M, Zhou W, Abbott D, Cheng N, Moothart C, Sigmund CD, Engelhardt JF. Wnt-responsive element controls Lef-1 promoter expression during submucosal gland morphogenesis. American Journal of Physiology. Lung Cellular and Molecular Physiology. 287: L752-63. PMID 15194563 DOI: 10.1152/Ajplung.00026.2004  0.378
2004 Dayal S, Arning E, Bottiglieri T, Böger RH, Sigmund CD, Faraci FM, Lentz SR. Cerebral vascular dysfunction mediated by superoxide in hyperhomocysteinemic mice. Stroke; a Journal of Cerebral Circulation. 35: 1957-62. PMID 15178827 DOI: 10.1161/01.Str.0000131749.81508.18  0.353
2004 Li WG, Gavrila D, Liu X, Wang L, Gunnlaugsson S, Stoll LL, McCormick ML, Sigmund CD, Tang C, Weintraub NL. Ghrelin inhibits proinflammatory responses and nuclear factor-kappaB activation in human endothelial cells. Circulation. 109: 2221-6. PMID 15117840 DOI: 10.1161/01.Cir.0000127956.43874.F2  0.326
2004 Lavoie JL, Lake-Bruse KD, Sigmund CD. Increased blood pressure in transgenic mice expressing both human renin and angiotensinogen in the renal proximal tubule. American Journal of Physiology. Renal Physiology. 286: F965-71. PMID 15075192 DOI: 10.1152/Ajprenal.00402.2003  0.458
2004 Keen HL, Ryan MJ, Beyer A, Mathur S, Scheetz TE, Gackle BD, Faraci FM, Casavant TL, Sigmund CD. Gene expression profiling of potential PPARgamma target genes in mouse aorta. Physiological Genomics. 18: 33-42. PMID 15054141 DOI: 10.1152/Physiolgenomics.00027.2004  0.624
2004 Lavoie JL, Cassell MD, Gross KW, Sigmund CD. Adjacent expression of renin and angiotensinogen in the rostral ventrolateral medulla using a dual-reporter transgenic model. Hypertension. 43: 1116-9. PMID 15037561 DOI: 10.1161/01.Hyp.0000125143.73301.94  0.394
2004 Ryan MJ, Didion SP, Mathur S, Faraci FM, Sigmund CD. Angiotensin II-induced vascular dysfunction is mediated by the AT1A receptor in mice. Hypertension. 43: 1074-9. PMID 15007032 DOI: 10.1161/01.Hyp.0000123074.89717.3D  0.392
2004 Wemmie JA, Coryell MW, Askwith CC, Lamani E, Leonard AS, Sigmund CD, Welsh MJ. Overexpression of acid-sensing ion channel 1a in transgenic mice increases acquired fear-related behavior. Proceedings of the National Academy of Sciences of the United States of America. 101: 3621-6. PMID 14988500 DOI: 10.1073/Pnas.0308753101  0.364
2004 Rahmouni K, Mark AL, Haynes WG, Sigmund CD. Adipose depot-specific modulation of angiotensinogen gene expression in diet-induced obesity. American Journal of Physiology. Endocrinology and Metabolism. 286: E891-5. PMID 14749209 DOI: 10.1152/Ajpendo.00551.2003  0.557
2004 Ryan MJ, Didion SP, Mathur S, Faraci FM, Sigmund CD. PPAR(gamma) agonist rosiglitazone improves vascular function and lowers blood pressure in hypertensive transgenic mice. Hypertension. 43: 661-6. PMID 14744930 DOI: 10.1161/01.Hyp.0000116303.71408.C2  0.44
2004 Ryan MJ, Sigmund CD. ACE, ACE inhibitors, and other JNK. Circulation Research. 94: 1-3. PMID 14715529 DOI: 10.1161/01.Res.0000112961.57831.87  0.333
2004 Nistala R, Zhang X, Sigmund CD. Differential expression of the closely linked KISS1, REN, and FLJ10761 genes in transgenic mice. Physiological Genomics. 17: 4-10. PMID 14709678 DOI: 10.1152/Physiolgenomics.00205.2003  0.421
2004 Ma X, Sigmund CD, Hingtgen SD, Tian X, Davisson RL, Abboud FM, Chapleau MW. Ganglionic action of angiotensin contributes to sympathetic activity in renin-angiotensinogen transgenic mice. Hypertension. 43: 312-6. PMID 14699002 DOI: 10.1161/01.Hyp.0000111835.16662.43  0.423
2004 Lavoie JL, Cassell MD, Gross KW, Sigmund CD. Localization of renin expressing cells in the brain, by use of a REN-eGFP transgenic model. Physiological Genomics. 16: 240-6. PMID 14625376 DOI: 10.1152/Physiolgenomics.00131.2003  0.37
2004 Ryan MJ, Sigmund CD. HPRT targeting: "Ets" a powerful tool for investigating endothelial-cell specific gene expression. Arteriosclerosis, Thrombosis, and Vascular Biology. 23: 1960-2. PMID 14617618 DOI: 10.1161/01.Atv.0000096608.44578.D9  0.409
2003 Bianco RA, Keen HL, Lavoie JL, Sigmund CD. Untraditional methods for targeting the kidney in transgenic mice. American Journal of Physiology. Renal Physiology. 285: F1027-33. PMID 14600026 DOI: 10.1152/Ajprenal.00207.2003  0.367
2003 Lavoie JL, Sigmund CD. Minireview: overview of the renin-angiotensin system--an endocrine and paracrine system. Endocrinology. 144: 2179-83. PMID 12746271 DOI: 10.1210/En.2003-0150  0.363
2003 Liu X, Huang X, Sigmund CD. Identification of a nuclear orphan receptor (Ear2) as a negative regulator of renin gene transcription. Circulation Research. 92: 1033-40. PMID 12690040 DOI: 10.1161/01.Res.0000071355.82009.43  0.359
2003 Baumbach GL, Sigmund CD, Faraci FM. Cerebral arteriolar structure in mice overexpressing human renin and angiotensinogen. Hypertension. 41: 50-5. PMID 12511529 DOI: 10.1161/01.Hyp.0000042427.05390.5C  0.446
2002 Didion SP, Ryan MJ, Didion LA, Fegan PE, Sigmund CD, Faraci FM. Increased superoxide and vascular dysfunction in CuZnSOD-deficient mice. Circulation Research. 91: 938-44. PMID 12433839 DOI: 10.1161/01.Res.0000043280.65241.04  0.41
2002 Baumbach GL, Sigmund CD, Bottiglieri T, Lentz SR. Structure of cerebral arterioles in cystathionine beta-synthase-deficient mice. Circulation Research. 91: 931-7. PMID 12433838 DOI: 10.1161/01.Res.0000041408.64867.1D  0.369
2002 Cvetkovic B, Keen HL, Zhang X, Davis D, Yang B, Sigmund CD. Physiological significance of two common haplotypes of human angiotensinogen using gene targeting in the mouse. Physiological Genomics. 11: 253-62. PMID 12388794 DOI: 10.1152/Physiolgenomics.00076.2002  0.454
2002 Morimoto S, Sigmund CD. Angiotensin mutant mice: a focus on the brain renin-angiotensin system. Neuropeptides. 36: 194-200. PMID 12359509 DOI: 10.1054/Npep.2002.0894  0.431
2002 Didion SP, Ryan MJ, Baumbach GL, Sigmund CD, Faraci FM. Superoxide contributes to vascular dysfunction in mice that express human renin and angiotensinogen. American Journal of Physiology. Heart and Circulatory Physiology. 283: H1569-76. PMID 12234811 DOI: 10.1152/Ajpheart.00079.2002  0.395
2002 Sigmund CD. Regulation of renin expression and blood pressure by vitamin D(3). The Journal of Clinical Investigation. 110: 155-6. PMID 12122105 DOI: 10.1172/Jci16160  0.406
2002 Morimoto S, Cassell MD, Sigmund CD. Glia- and neuron-specific expression of the renin-angiotensin system in brain alters blood pressure, water intake, and salt preference. The Journal of Biological Chemistry. 277: 33235-41. PMID 12080069 DOI: 10.1074/Jbc.M204309200  0.469
2002 Morimoto S, Cassell MD, Sigmund CD. Neuron-specific expression of human angiotensinogen in brain causes increased salt appetite. Physiological Genomics. 9: 113-20. PMID 12006677 DOI: 10.1152/Physiolgenomics.00007.2002  0.43
2002 Nistala R, Sigmund CD. A reliable and efficient method for deleting operational sequences in PACs and BACs. Nucleic Acids Research. 30: e41. PMID 12000846 DOI: 10.1093/Nar/30.10.E41  0.378
2002 Lazartigues E, Dunlay SM, Loihl AK, Sinnayah P, Lang JA, Espelund JJ, Sigmund CD, Davisson RL. Brain-selective overexpression of angiotensin (AT1) receptors causes enhanced cardiovascular sensitivity in transgenic mice. Circulation Research. 90: 617-24. PMID 11909827 DOI: 10.1161/01.Res.0000012460.85923.F0  0.45
2002 Ryan MJ, Sigmund CD. Use of transgenic and knockout strategies in mice. Seminars in Nephrology. 22: 154-60. PMID 11891509 DOI: 10.1053/Snep.2002.30220  0.377
2002 Stec DE, Keen HL, Sigmund CD. Lower blood pressure in floxed angiotensinogen mice after adenoviral delivery of Cre-recombinase. Hypertension (Dallas, Tex. : 1979). 39: 629-33. PMID 11882621 DOI: 10.1161/Hy0202.103418  0.421
2002 Ryan MJ, Didion SP, Davis DR, Faraci FM, Sigmund CD. Endothelial dysfunction and blood pressure variability in selected inbred mouse strains. Arteriosclerosis, Thrombosis, and Vascular Biology. 22: 42-8. PMID 11788459 DOI: 10.1161/Hq0102.101098  0.36
2002 Morimoto S, Cassell MD, Sigmund CD. The brain renin-angiotensin system in transgenic mice carrying a highly regulated human renin transgene. Circulation Research. 90: 80-6. PMID 11786522 DOI: 10.1161/Hh0102.102272  0.496
2001 Sigmund CD, Stec DE. Genetic Manipulation of the Renin-Angiotensin System Using Cre-loxP-Recombinase. Methods in Molecular Medicine. 51: 53-65. PMID 21331709 DOI: 10.1385/1-59259-087-X:53  0.409
2001 Myung PS, Derimanov GS, Jordan MS, Punt JA, Liu QH, Judd BA, Meyers EE, Sigmund CD, Freedman BD, Koretzky GA. Differential requirement for SLP-76 domains in T cell development and function. Immunity. 15: 1011-26. PMID 11754821 DOI: 10.1016/S1074-7613(01)00253-9  0.312
2001 Wilson K, Fry GL, Chappell DA, Sigmund CD, Medh JD. Macrophage-specific expression of human lipoprotein lipase accelerates atherosclerosis in transgenic apolipoprotein e knockout mice but not in C57BL/6 mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 21: 1809-15. PMID 11701470 DOI: 10.1161/Hq1101.097805  0.409
2001 Sigmund CD. Genetic manipulation of the renin-angiotensin system in the kidney. Acta Physiologica Scandinavica. 173: 67-73. PMID 11678728 DOI: 10.1046/J.1365-201X.2001.00886.X  0.352
2001 Shi Q, Gross KW, Sigmund CD. NF-Y antagonizes renin enhancer function by blocking stimulatory transcription factors. Hypertension. 38: 332-6. PMID 11566900 DOI: 10.1161/01.Hyp.38.3.332  0.436
2001 Pan L, Black TA, Shi Q, Jones CA, Petrovic N, Loudon J, Kane C, Sigmund CD, Gross KW. Critical roles of a cyclic AMP responsive element and an E-box in regulation of mouse renin gene expression. The Journal of Biological Chemistry. 276: 45530-8. PMID 11564732 DOI: 10.1074/Jbc.M103010200  0.518
2001 Stec DE, Morimoto S, Sigmund CD. Vectors for high-level expression of cDNAs controlled by tissue-specific promoters in transgenic mice. Biotechniques. 31: 256-8, 260. PMID 11515356 DOI: 10.2144/01312Bm03  0.399
2001 Morimoto S, Cassell MD, Beltz TG, Johnson AK, Davisson RL, Sigmund CD. Elevated blood pressure in transgenic mice with brain-specific expression of human angiotensinogen driven by the glial fibrillary acidic protein promoter. Circulation Research. 89: 365-72. PMID 11509454 DOI: 10.1161/Hh1601.094988  0.471
2001 Sigmund CD. Genetic manipulation of the renin-angiotensin system: targeted expression of the renin-angiotensin system in the kidney. American Journal of Hypertension. 14: 33S-37S. PMID 11411763 DOI: 10.1016/S0895-7061(01)02067-2  0.42
2001 Dayal S, Bottiglieri T, Arning E, Maeda N, Malinow MR, Sigmund CD, Heistad DD, Faraci FM, Lentz SR. Endothelial dysfunction and elevation of S-adenosylhomocysteine in cystathionine beta-synthase-deficient mice. Circulation Research. 88: 1203-9. PMID 11397788 DOI: 10.1161/Hh1101.092180  0.387
2001 Stec DE, Sigmund CD. Physiological insights from genetic manipulation of the renin-angiotensin system. News in Physiological Sciences : An International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society. 16: 80-4. PMID 11390954 DOI: 10.1152/Physiologyonline.2001.16.2.80  0.323
2001 Keen HL, Sigmund CD. Paradoxical regulation of short promoter human renin transgene by angiotensin ii. Hypertension (Dallas, Tex. : 1979). 37: 403-7. PMID 11230308 DOI: 10.1161/01.Hyp.37.2.403  0.401
2001 Ding Y, Sigmund CD. Androgen-dependent regulation of human angiotensinogen expression in KAP-hAGT transgenic mice. American Journal of Physiology. Renal Physiology. 280: F54-60. PMID 11133514 DOI: 10.1152/Ajprenal.2001.280.1.F54  0.631
2001 Ding Y, Stec DE, Sigmund CD. Genetic evidence that lethality in angiotensinogen-deficient mice is due to loss of systemic but not renal angiotensinogen. The Journal of Biological Chemistry. 276: 7431-6. PMID 11096065 DOI: 10.1074/Jbc.M003892200  0.65
2001 Shi Q, Gross KW, Sigmund CD. Retinoic acid-mediated activation of the mouse renin enhancer. The Journal of Biological Chemistry. 276: 3597-603. PMID 11058598 DOI: 10.1074/Jbc.M008361200  0.554
2000 Sinn PL, Sigmund CD. Identification of three human renin mRNA isoforms from alternative tissue-specific transcriptional initiation. Physiological Genomics. 3: 25-31. PMID 11015597 DOI: 10.1152/Physiolgenomics.2000.3.1.25  0.416
2000 Lake-Bruse KD, Sigmund CD. Transgenic and knockout mice to study the renin-angiotensin system and other interacting vasoactive pathways. Current Hypertension Reports. 2: 211-6. PMID 10981151 DOI: 10.1007/S11906-000-0084-1  0.425
2000 Davisson RL, Oliverio MI, Coffman TM, Sigmund CD. Divergent functions of angiotensin II receptor isoforms in the brain Journal of Clinical Investigation. 106: 103-106. PMID 10880053 DOI: 10.1172/Jci10022  0.406
2000 Sigmund CD. Viewpoint: are studies in genetically altered mice out of control? Arteriosclerosis, Thrombosis, and Vascular Biology. 20: 1425-9. PMID 10845854 DOI: 10.1161/01.Atv.20.6.1425  0.328
2000 Cvetkovic B, Sigmund CD. Understanding hypertension through genetic manipulation in mice. Kidney International. 57: 863-74. PMID 10720939 DOI: 10.1046/J.1523-1755.2000.057003863.X  0.419
2000 Didion SP, Sigmund CD, Faraci FM. Impaired endothelial function in transgenic mice expressing both human renin and human angiotensinogen. Stroke. 31: 760-4; discussion 76. PMID 10700516 DOI: 10.1161/01.Str.31.3.760  0.394
2000 Wang Q, Sigmund CD, Lin JJ. Identification of cis elements in the cardiac troponin T gene conferring specific expression in cardiac muscle of transgenic mice. Circulation Research. 86: 478-84. PMID 10700454 DOI: 10.1161/01.Res.86.4.478  0.379
2000 Sinn PL, Sigmund CD. Transgenic models as tools for studying the regulation of human renin expression. Regulatory Peptides. 86: 77-82. PMID 10672905 DOI: 10.1016/S0167-0115(99)00097-X  0.433
2000 Cvetkovic B, Yang B, Williamson RA, Sigmund CD. Appropriate tissue- and cell-specific expression of a single copy human angiotensinogen transgene specifically targeted upstream of the HPRT locus by homologous recombination. The Journal of Biological Chemistry. 275: 1073-8. PMID 10625648 DOI: 10.1074/Jbc.275.2.1073  0.422
2000 Faraci FM, Sigmund CD. Vascular biology in genetically altered mice : smaller vessels, bigger insight. Circulation Research. 85: 1214-25. PMID 10590250 DOI: 10.1161/01.Res.85.12.1214  0.426
2000 Sinn PL, Davis DR, Sigmund CD. Highly regulated cell type-restricted expression of human renin in mice containing 140- or 160-kilobase pair P1 phage artificial chromosome transgenes. The Journal of Biological Chemistry. 274: 35785-93. PMID 10585461 DOI: 10.1074/Jbc.274.50.35785  0.497
2000 Keen HL, Sigmund CD. Angiotensin Paradoxically Upregulates a Human Renin Transgene Containing a 900bp Promoter by a Pressure-Independent Mechanism Hypertension. 36: 728-728. DOI: 10.1161/01.Hyp.36.Suppl_1.728-D  0.443
2000 Morimoto S, Beltz TG, Johnson K, Davidson RL, Cassell MD, Sigmund CD. Generation of a Transgenic Mouse Model Exhibiting Brain Specific Expression of Human Angiotensinogen Hypertension. 36: 728-728. DOI: 10.1161/01.Hyp.36.Suppl_1.728-B  0.467
2000 Cvetkovic B, Yang G, Sigmund CD. Partial Tissue-Specific Expression of Two Human Angiotensinogen Promoter-Lacz Transgenes in Mice Hypertension. 36: 695-695. DOI: 10.1161/01.Hyp.36.Suppl_1.695-B  0.408
2000 Ding Y, Sigmund CD. Genetic Evidence That Loss of Intra-Renal Angiotensinogen Is not the Cause of Lethality in Angiotensinogen Deficient Mice Hypertension. 36: 687-687. DOI: 10.1161/01.Hyp.36.Suppl_1.687  0.622
2000 Lazartigues E, Dunlay SM, Sinnayah P, Sigmund CD, Davisson RL. Brain-Selective Expression of Exogenous Angiotensin (AT1) Receptors Causes Enhanced Cardiovascular Sensitivity. Hypertension. 36: 681-681. DOI: 10.1161/01.Hyp.36.Suppl_1.681-B  0.392
2000 Phillips MI, Kimura B, Zhang YC, Gelband CH, Sigmund CD, Mohuczy D. Gene Therapy for Hypertension: Recombinant Adeno-Associated Virus Vector Delivery of Angiotensin Type 1 Receptor Antisense in Hypertensive Double Transgenic Mice Hypertension. 36: 270-270. DOI: 10.1161/01.Hyp.36.Suppl_1.270  0.451
1999 Davisson RL, Ding Y, Stec DE, Catterall JF, Sigmund CD. Novel mechanism of hypertension revealed by cell-specific targeting of human angiotensinogen in transgenic mice. Physiological Genomics. 1: 3-9. PMID 11015555 DOI: 10.1152/Physiolgenomics.1999.1.1.3  0.646
1999 Mark AL, Shaffer RA, Correia ML, Morgan DA, Sigmund CD, Haynes WG. Contrasting blood pressure effects of obesity in leptin-deficient ob/ob mice and agouti yellow obese mice. Journal of Hypertension. 17: 1949-53. PMID 10703894 DOI: 10.1097/00004872-199917121-00026  0.397
1999 Sinn PL, Zhang X, Sigmund CD. JG cell expression and partial regulation of a human renin genomic transgene driven by a minimal renin promoter. The American Journal of Physiology. 277: F634-42. PMID 10516288 DOI: 10.1152/Ajprenal.1999.277.4.F634  0.447
1999 Shi Q, Black TA, Gross KW, Sigmund CD. Species-specific differences in positive and negative regulatory elements in the renin gene enhancer. Circulation Research. 85: 479-88. PMID 10488050 DOI: 10.1161/01.Res.85.6.479  0.486
1999 Lake-Bruse KD, Faraci FM, Shesely EG, Maeda N, Sigmund CD, Heistad DD. Gene transfer of endothelial nitric oxide synthase (eNOS) in eNOS-deficient mice. The American Journal of Physiology. 277: H770-6. PMID 10444505 DOI: 10.1152/Ajpheart.1999.277.2.H770  0.389
1999 Stec DE, Davisson RL, Haskell RE, Davidson BL, Sigmund CD. Efficient liver-specific deletion of a floxed human angiotensinogen transgene by adenoviral delivery of Cre recombinase in vivo. The Journal of Biological Chemistry. 274: 21285-90. PMID 10409686 DOI: 10.1074/Jbc.274.30.21285  0.425
1999 Sinn PL, Sigmund CD. Human renin mRNA stability is increased in response to cAMP in Calu-6 cells. Hypertension (Dallas, Tex. : 1979). 33: 900-5. PMID 10082506 DOI: 10.1161/01.Hyp.33.3.900  0.304
1999 Yang G, Gray TS, Sigmund CD, Cassell MD. The angiotensinogen gene is expressed in both astrocytes and neurons in murine central nervous system. Brain Research. 817: 123-31. PMID 9889347 DOI: 10.1016/S0006-8993(98)01236-0  0.377
1999 Yan Y, Chen R, Pitarresi T, Sigmund CD, Gross KW, Sealey JE, Laragh JH, Catanzaro DF. Kidney is the only source of human plasma renin in 45-kb human renin transgenic mice. Circulation Research. 83: 1279-88. PMID 9851945 DOI: 10.1161/01.Res.83.12.1279  0.432
1999 Stec DE, Sigmund CD. Modifiable gene expression in mice: kidney-specific deletion of a target gene via the cre-loxP system. Experimental Nephrology. 6: 568-75. PMID 9807030 DOI: 10.1159/000020573  0.369
1998 Yang G, Sigmund CD. Developmental expression of human angiotensinogen in transgenic mice. American Journal of Physiology. Renal Physiology. 274: F932-F939. PMID 29586414 DOI: 10.1152/Ajprenal.1998.274.5.F932  0.411
1998 Faraci FM, Sigmund CD, Shesely EG, Maeda N, Heistad DD. Responses of carotid artery in mice deficient in expression of the gene for endothelial NO synthase. American Journal of Physiology. Heart and Circulatory Physiology. 274: H564-H570. PMID 29586063 DOI: 10.1152/Ajpheart.1998.274.2.H564  0.382
1998 Stec DE, Davisson RL, Sigmund CD. Transgenesis and gene targeting in the mouse; tools for studying genetic determinants of hypertension. Trends in Cardiovascular Medicine. 8: 256-64. PMID 14987561 DOI: 10.1016/S1050-1738(98)00016-4  0.355
1998 Davisson RL, Yang G, Beltz TG, Cassell MD, Johnson AK, Sigmund CD. The brain renin-angiotensin system contributes to the hypertension in mice containing both the human renin and human angiotensinogen transgenes. Circulation Research. 83: 1047-58. PMID 9815152 DOI: 10.1161/01.Res.83.10.1047  0.473
1998 Yang G, Sigmund CD. Regulatory elements required for human angiotensinogen expression in HepG2 cells are dispensable in transgenic mice. Hypertension (Dallas, Tex. : 1979). 31: 734-40. PMID 9495255 DOI: 10.1161/01.Hyp.31.3.734  0.434
1997 Ding Y, Davisson RL, Hardy DO, Zhu LJ, Merrill DC, Catterall JF, Sigmund CD. The kidney androgen-regulated protein promoter confers renal proximal tubule cell-specific and highly androgen-responsive expression on the human angiotensinogen gene in transgenic mice. The Journal of Biological Chemistry. 272: 28142-8. PMID 9346970 DOI: 10.1074/Jbc.272.44.28142  0.644
1997 Yan Y, Jones CA, Sigmund CD, Gross KW, Catanzaro DF. Conserved enhancer elements in human and mouse renin genes have different transcriptional effects in As4.1 cells. Circulation Research. 81: 558-66. PMID 9314837 DOI: 10.1161/01.Res.81.4.558  0.384
1997 Petrovic N, Kane CM, Sigmund CD, Gross KW. Downregulation of renin gene expression by interleukin-1. Hypertension (Dallas, Tex. : 1979). 30: 230-5. PMID 9260985 DOI: 10.1161/01.Hyp.30.2.230  0.392
1997 Davisson RL, Kim HS, Krege JH, Lager DJ, Smithies O, Sigmund CD. Complementation of reduced survival, hypotension, and renal abnormalities in angiotensinogen-deficient mice by the human renin and human angiotensinogen genes. The Journal of Clinical Investigation. 99: 1258-64. PMID 9077534 DOI: 10.1172/Jci119283  0.411
1997 Jones CA, Petrovic N, Novak EK, Swank RT, Sigmund CD, Gross KW. Biosynthesis of renin in mouse kidney tumor As4.1 cells. European Journal of Biochemistry. 243: 181-90. PMID 9030738 DOI: 10.1111/J.1432-1033.1997.0181A.X  0.312
1997 Ying L, Morris BJ, Sigmund CD. Transactivation of the human renin promoter by the cyclic AMP/protein kinase A pathway is mediated by both cAMP-responsive element binding protein-1 (CREB)-dependent and CREB-independent mechanisms in Calu-6 cells. The Journal of Biological Chemistry. 272: 2412-20. PMID 8999953 DOI: 10.1074/Jbc.272.4.2412  0.381
1996 Davisson RL, Sigmund CD. Transgenic animal models as tools for studying renal developmental physiology Pediatric Nephrology. 10: 798-803. PMID 8971910 DOI: 10.1007/S004670050220  0.349
1996 Davisson RL, Nuutinen N, Coleman ST, Sigmund CD. Inappropriate splicing of a chimeric gene containing a large internal exon results in exon skipping in transgenic mice Nucleic Acids Research. 24: 4023-4028. PMID 8918807 DOI: 10.1093/Nar/24.20.4023  0.342
1996 Petrovic N, Black TA, Fabian JR, Kane C, Jones CA, Loudon JA, Abonia JP, Sigmund CD, Gross KW. Role of proximal promoter elements in regulation of renin gene transcription. The Journal of Biological Chemistry. 271: 22499-505. PMID 8798416 DOI: 10.1074/Jbc.271.37.22499  0.38
1996 Lang JA, Ying LH, Morris BJ, Sigmund CD. Transcriptional and posttranscriptional mechanisms regulate human renin gene expression in Calu-6 cells. The American Journal of Physiology. 271: F94-100. PMID 8760248 DOI: 10.1152/Ajprenal.1996.271.1.F94  0.369
1996 Thompson MW, Smith SB, Sigmund CD. Regulation of human renin mRNA expression and protein release in transgenic mice Hypertension. 28: 290-296. PMID 8707396 DOI: 10.1161/01.Hyp.28.2.290  0.464
1996 Merrill DC, Thompson MW, Carney CL, Granwehr BP, Schlager G, Robillard JE, Sigmund CD. Chronic hypertension and altered baroreflex responses in transgenic mice containing the human renin and human angiotensinogen genes. The Journal of Clinical Investigation. 97: 1047-55. PMID 8613528 DOI: 10.1172/Jci118497  0.477
1996 Thompson MW, Merrill DC, Sigmund CD. CHARACTERIZATION OF HUMAN RENIN TRANSGENE RESPONSE TO INCREASED CIRCULATING ANGIOTENSIN II AND HYPERTENSION IN TRANSGENIC MICE. • 2209 Pediatric Research. 39: 371-371. DOI: 10.1203/00006450-199604001-02233  0.471
1996 Merrill DC, Smith S, Granwehr B, Carney C, Sigmund C. HUMAN RENIN GENE EXPRESSION DURING PREGNANCY IN TRANSGENIC MICE. † 367 Pediatric Research. 39: 64-64. DOI: 10.1203/00006450-199604001-00387  0.408
1995 Thompson HA, Burson JM, Lang JA, Gross KW, Sigmund CD. Tissue-specific expression of novel messenger ribonucleic acids cloned from a renin-expressing kidney tumor cell line (As4.1) Endocrinology. 136: 3037-3045. PMID 7789330 DOI: 10.1210/Endo.136.7.7789330  0.382
1995 Lang JA, Yang G, Kern JA, Sigmund CD. Endogenous human renin expression and promoter activity in CALU-6, a pulmonary carcinoma cell line. Hypertension (Dallas, Tex. : 1979). 25: 704-10. PMID 7721420 DOI: 10.1161/01.Hyp.25.4.704  0.388
1995 Smith DL, Jeyapalan S, Lang JA, Guo XH, Sigmund CD, Morris BJ. Human renin 5'-flanking DNA to nucleotide-2750. Dna Sequence : the Journal of Dna Sequencing and Mapping. 5: 319-21. PMID 7579588 DOI: 10.3109/10425179509030988  0.349
1995 Thompson MW, Merrill DC, Yang G, Robillard JE, Sigmund CD. Transgenic animals in the study of blood pressure regulation and hypertension. The American Journal of Physiology. 269: E793-803. PMID 7491928 DOI: 10.1152/Ajpendo.1995.269.5.E793  0.366
1994 Sigmund CD. Expression of the human renin gene in transgenic mice throughout ontogeny. Pediatric Nephrology (Berlin, Germany). 7: 639-45. PMID 8251339 DOI: 10.1007/Bf00852572  0.411
1994 Lang JA, Sinclair NL, Burson JM, Sigmund CD. Transgenic animals as tools in hypertension research. Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine (New York, N.Y.). 205: 106-18. PMID 8108459 DOI: 10.3181/00379727-205-43685  0.334
1994 Burson JM, Aguilera G, Gross KW, Sigmund CD. Differential expression of angiotensin receptor 1A and 1B in mouse. The American Journal of Physiology. 267: E260-7. PMID 8074205 DOI: 10.1152/Ajpendo.1994.267.2.E260  0.405
1994 Catanzaro DF, Sun J, Gilbert MT, Yan Y, Black T, Sigmund C, Gross KW. A Pit-1 binding site in the human renin gene promoter stimulates activity in pituitary, placental and juxtaglomerular cells Kidney International. 46: 1513-1515. PMID 7699993 DOI: 10.1038/Ki.1994.433  0.384
1993 Sigmund CD. Major approaches for generating and analyzing transgenic mice. An overview. Hypertension (Dallas, Tex. : 1979). 22: 599-607. PMID 8406666 DOI: 10.1161/01.Hyp.22.4.599  0.342
1992 Sigmund CD, Jones CA, Kane CM, Wu C, Lang JA, Gross KW. Regulated tissue- and cell-specific expression of the human renin gene in transgenic mice. Circulation Research. 70: 1070-9. PMID 1568298 DOI: 10.1161/01.Res.70.5.1070  0.461
1991 Jacob HJ, Sigmund CD, Shockley TR, Gross KW, Dzau VJ. Renin promoter SV40 T-antigen transgenic mouse: A model of primary renal vascular hyperplasia Hypertension. 17: 1167-1172. PMID 2045162 DOI: 10.1161/01.Hyp.17.6.1167  0.379
1991 Sigmund CD, Jones CA, Jacob HJ, Ingelfinger J, Kim U, Gamble D, Dzau VJ, Gross KW. Pathophysiology of vascular smooth muscle in renin promoter-T-antigen transgenic mice. The American Journal of Physiology. 260: F249-57. PMID 1996675 DOI: 10.1152/Ajprenal.1991.260.2.F249  0.442
1991 Sigmund CD, Gross KW. Differential expression of the murine and rat renin genes in peripheral subcutaneous tissue. Biochemical and Biophysical Research Communications. 173: 218-23. PMID 1979487 DOI: 10.1016/S0006-291X(05)81044-7  0.402
1991 Sigmund CD, Gross KW. Structure, expression, and regulation of the murine renin genes. Hypertension (Dallas, Tex. : 1979). 18: 446-57. PMID 1916990 DOI: 10.1161/01.Hyp.18.4.446  0.452
1990 Jones CA, Sigmund CD, McGowan RA, Kane-Haas CM, Gross KW. Expression of murine renin genes during fetal development. Molecular Endocrinology (Baltimore, Md.). 4: 375-83. PMID 2188116 DOI: 10.1210/Mend-4-3-375  0.407
1990 Sigmund CD, Jones CA, Mullins JJ, Kim U, Gross KW. Expression of murine renin genes in subcutaneous connective tissue. Proceedings of the National Academy of Sciences of the United States of America. 87: 7993-7. PMID 2172970 DOI: 10.1073/Pnas.87.20.7993  0.401
1990 Sigmund CD, Jones CA, Fabian JR, Mullins JJ, Gross KW. Tissue and cell specific expression of a renin promoter-reporter gene construct in transgenic mice. Biochemical and Biophysical Research Communications. 170: 344-50. PMID 1695507 DOI: 10.1016/0006-291X(90)91280-6  0.406
1989 Mullins JJ, Sigmund CD, Kane-Haas C, Wu CZ, Pacholec F, Zeng Q, Gross KW. Studies on the regulation of renin genes using transgenic mice. Clinical and Experimental Hypertension. Part a, Theory and Practice. 10: 1157-67. PMID 3066526 DOI: 10.1080/07300077.1988.11878808  0.421
1989 Mullins J, Sigmund C, Kane-Haas C, Gross K, McGowan R. Expression of the DBA/2J Ren-2 gene in the adrenal gland of transgenic mice. The Embo Journal. 8: 4065-4072. DOI: 10.1002/J.1460-2075.1989.Tb08590.X  0.424
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