Alexandros Makriyannis - Publications

1974- Medicinal Chemistry University of Connecticut, Storrs, CT, United States 
 2004- Northeastern University, Boston, MA, United States 

165 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Malamas MS, Farah SI, Lamani M, Pelekoudas DN, Perry NT, Rajarshi G, Miyabe CY, Chandrashekhar H, West J, Pavlopoulos S, Makriyannis A. Design and synthesis of cyanamides as potent and selective N-acylethanolamine acid amidase inhibitors. Bioorganic & Medicinal Chemistry. 115195. PMID 31761726 DOI: 10.1016/j.bmc.2019.115195  0.44
2019 Imai Y, Meyer KJ, Iinishi A, Favre-Godal Q, Green R, Manuse S, Caboni M, Mori M, Niles S, Ghiglieri M, Honrao C, Ma X, Guo J, Makriyannis A, Linares-Otoya L, et al. A new antibiotic selectively kills Gram-negative pathogens. Nature. PMID 31747680 DOI: 10.1038/s41586-019-1791-1  0.68
2019 Kangas BD, Zakarian AS, Vemuri K, Alapafuja SO, Jiang S, Nikas SP, Makriyannis A, Bergman J. Cannabinoid Antagonist Drug Discrimination in Nonhuman Primates. The Journal of Pharmacology and Experimental Therapeutics. PMID 31641018 DOI: 10.1124/jpet.119.261818  0.44
2019 Lamani M, Malamas MS, Farah SI, Shukla VG, Almeida MF, Weerts CM, Anderson J, Wood JT, Farizatto KLG, Bahr BA, Makriyannis A. Piperidine and piperazine inhibitors of fatty acid amide hydrolase targeting excitotoxic pathology. Bioorganic & Medicinal Chemistry. 115096. PMID 31629610 DOI: 10.1016/j.bmc.2019.115096  0.44
2019 Alapafuja SO, Nikas SP, Ho TC, Tong F, Benchama O, Makriyannis A. Chain Substituted Cannabilactones with Selectivity for the CB2 Cannabinoid Receptor. Molecules (Basel, Switzerland). 24. PMID 31581433 DOI: 10.3390/molecules24193559  0.44
2019 Gaitán AV, Wood JT, Solomons NW, Donohue JA, Ji L, Liu Y, Nikas SP, Zhang F, Allen LH, Makriyannis A, Lammi-Keefe CJ. Endocannabinoid Metabolome Characterization of Milk from Guatemalan Women Living in the Western Highlands. Current Developments in Nutrition. 3: nzz018. PMID 31111118 DOI: 10.1093/cdn/nzz018  0.44
2018 Li X, Hua T, Vemuri K, Ho JH, Wu Y, Wu L, Popov P, Benchama O, Zvonok N, Locke K, Qu L, Han GW, Iyer MR, Cinar R, Coffey NJ, ... ... Makriyannis A, et al. Crystal Structure of the Human Cannabinoid Receptor CB2. Cell. PMID 30639103 DOI: 10.1016/j.cell.2018.12.011  0.32
2018 Li AL, Lin X, Dhopeshwarkar AS, Thomaz AC, Carey LM, Liu Y, Nikas SP, Makriyannis A, Mackie K, Hohmann AG. The cannabinoid CB2 agonist AM1710 differentially suppresses distinct pathological pain states and attenuates morphine tolerance and withdrawal. Molecular Pharmacology. PMID 30504240 DOI: 10.1124/mol.118.113233  0.44
2018 Chopda GR, Nikas SP, Sharma R, Kulkarni S, Makriyannis A, Paronis CA. Cannabinoid-induced lower lip retraction in rats. Psychopharmacology. PMID 30460515 DOI: 10.1007/s00213-018-5125-z  0.44
2018 Alapafuja SO, Malamas MS, Shukla V, Zvonok A, Miller S, Daily L, Rajarshi G, Miyabe CY, Chandrashekhar H, Wood J, Tyukhtenko S, Straiker A, Makriyannis A. Synthesis and evaluation of potent and selective MGL inhibitors as a glaucoma treatment. Bioorganic & Medicinal Chemistry. PMID 30446439 DOI: 10.1016/j.bmc.2018.11.003  0.44
2018 Szymanski D, Papanastasiou M, Pandarinathan L, Zvonok N, Janero DR, Pavlopoulos S, Vouros P, Makriyannis A. Aliphatic Azides as Selective Cysteine Labeling Reagents for Integral Membrane Proteins. Journal of Medicinal Chemistry. PMID 30444608 DOI: 10.1021/acs.jmedchem.8b01302  0.44
2018 Sagheddu C, Scherma M, Congiu M, Fadda P, Carta G, Banni S, Wood JT, Makriyannis A, Malamas MS, Pistis M. Inhibition of N-acylethanolamine acid amidase reduces nicotine-induced dopamine activation and reward. Neuropharmacology. 144: 327-336. PMID 30439418 DOI: 10.1016/j.neuropharm.2018.11.013  0.44
2018 Iliopoulos-Tsoutsouvas C, Kulkarni RN, Makriyannis A, Nikas SP. Fluorescent probes for G-protein-coupled receptor drug discovery. Expert Opinion On Drug Discovery. 1-15. PMID 30249143 DOI: 10.1080/17460441.2018.1518975  0.44
2018 Gaitán AV, Wood JT, Zhang F, Makriyannis A, Lammi-Keefe CJ. Endocannabinoid Metabolome Characterization of Transitional and Mature Human Milk. Nutrients. 10. PMID 30213124 DOI: 10.3390/nu10091294  0.32
2018 Liu Y, Ji L, Eno M, Kudalkar S, Li A, Schimpgen M, Benchama O, Morales P, Xu S, Hurst DP, Wu S, Mohammad KA, Wood JT, Zvonok N, Papahatjis D, ... ... Makriyannis A, et al. (R)-N-(1-Methyl-2-hydroxyethyl)-13-(S)-methyl-arachidonamide (AMG315): A Novel Chiral Potent Endocannabinoid Ligand with Stability to Metabolizing Enzymes. Journal of Medicinal Chemistry. PMID 30196704 DOI: 10.1021/acs.jmedchem.8b00611  0.44
2018 Malamas MS, Raghav JG, Ma X, Honrao C, Wood JT, Benchama O, Zhou H, Mallipeddi S, Makriyannis A. Oximes short-acting CB1 receptor agonists. Bioorganic & Medicinal Chemistry. PMID 30122284 DOI: 10.1016/j.bmc.2018.08.003  0.44
2018 Sticht MA, Lau DD, Keenan CM, Cavin JB, Morena M, Vemuri VK, Makriyannis A, Cravatt BF, Sharkey KA, Hill MN. Endocannabinoid regulation of homeostatic feeding and stress-induced alterations in food intake in male rats. British Journal of Pharmacology. PMID 30051485 DOI: 10.1111/bph.14453  0.36
2018 Miller S, Kulkarni S, Ciesielski A, Nikas SP, Mackie K, Makriyannis A, Straiker A. Controlled-Deactivation CB1 Receptor Ligands as a Novel Strategy to Lower Intraocular Pressure. Pharmaceuticals (Basel, Switzerland). 11. PMID 29786643 DOI: 10.3390/ph11020050  0.44
2018 Mallipeddi S, Zvonok N, Makriyannis A. Expression, Purification and Characterization of the Human Cannabinoid 1 Receptor. Scientific Reports. 8: 2935. PMID 29440756 DOI: 10.1038/s41598-018-19749-5  0.36
2018 Tyukhtenko S, Rajarshi G, Karageorgos I, Zvonok N, Gallagher ES, Huang H, Vemuri K, Hudgens JW, Ma X, Nasr ML, Pavlopoulos S, Makriyannis A. Effects of Distal Mutations on the Structure, Dynamics and Catalysis of Human Monoacylglycerol Lipase. Scientific Reports. 8: 1719. PMID 29379013 DOI: 10.1038/s41598-017-19135-7  0.44
2017 Pavlopoulos S, Pelekoudas DN, Benchama O, Rawlins CM, Agar JN, West JM, Malamas M, Zvonok N, Makriyannis A. Secretion, isotopic labeling and deglycosylation of N-Acylethanolamine acid amidase for biophysical studies. Protein Expression and Purification. PMID 29253688 DOI: 10.1016/j.pep.2017.12.005  0.44
2017 Ruiz de Azua I, Mancini G, Srivastava RK, Rey AA, Cardinal P, Tedesco L, Zingaretti CM, Sassmann A, Quarta C, Schwitter C, Conrad A, Wettschureck N, Vemuri VK, Makriyannis A, Hartwig J, et al. Adipocyte cannabinoid receptor CB1 regulates energy homeostasis and alternatively activated macrophages. The Journal of Clinical Investigation. PMID 29035280 DOI: 10.1172/JCI83626  0.36
2017 Leonard MZ, Alapafuja SO, Ji L, Shukla VG, Liu Y, Nikas SP, Makriyannis A, Bergman J, Kangas BD. Cannabinoid CB1 Discrimination: Effects of Endocannabinoids and Catabolic Enzyme Inhibitors. The Journal of Pharmacology and Experimental Therapeutics. PMID 28947487 DOI: 10.1124/jpet.117.244392  0.44
2017 Farizatto KLG, McEwan SA, Naidoo V, Nikas SP, Shukla VG, Almeida MF, Byrd A, Romine H, Karanian DA, Makriyannis A, Bahr BA. Inhibitor of Endocannabinoid Deactivation Protects Against In Vitro and In Vivo Neurotoxic Effects of Paraoxon. Journal of Molecular Neuroscience : Mn. PMID 28803438 DOI: 10.1007/s12031-017-0963-4  0.44
2017 Hua T, Vemuri K, Nikas SP, Laprairie RB, Wu Y, Qu L, Pu M, Korde A, Jiang S, Ho JH, Han GW, Ding K, Li X, Liu H, Hanson MA, ... ... Makriyannis A, et al. Crystal structures of agonist-bound human cannabinoid receptor CB1. Nature. PMID 28678776 DOI: 10.1038/nature23272  0.44
2017 Ho TC, Shimada N, Tius MA, Nikas SP, Zhang W, Makriyannis A. C1'-Azacycloalkyl Hexahydrocannabinols. The Journal of Organic Chemistry. PMID 28677397 DOI: 10.1021/acs.joc.7b00988  0.44
2017 Mallipeddi S, Kreimer S, Zvonok N, Vemuri VK, Karger BL, Ivanov AR, Makriyannis A. Binding Site Characterization of AM1336, a Novel Covalent Inverse Agonist at Human Cannabinoid 2 Receptor, Using Mass Spectrometric Analysis. Journal of Proteome Research. PMID 28374590 DOI: 10.1021/acs.jproteome.7b00023  0.36
2017 Zhou H, Peng Y, Halikhedkar A, Fan P, Janero DR, Thakur GA, Mercier RW, Sun X, Ma X, Makriyannis A. Human Cannabinoid Receptor 2 Ligand-interaction Motif: Transmembrane Helix 2 Cysteine, C2.59(89), as Determinant of Classical Cannabinoid Agonist Activity and Binding Pose. Acs Chemical Neuroscience. PMID 28220706 DOI: 10.1021/acschemneuro.7b00003  0.48
2017 McLaughlin PJ, Jagielo-Miller JE, Plyler ES, Schutte KK, Vemuri VK, Makriyannis A. Differential effects of cannabinoid CB1 inverse agonists and antagonists on impulsivity in male Sprague Dawley rats: identification of a possibly clinically relevant vulnerability involving the serotonin 5HT1A receptor. Psychopharmacology. PMID 28144708 DOI: 10.1007/s00213-017-4548-2  0.36
2016 Mallipeddi S, Janero DR, Zvonok N, Makriyannis A. Functional selectivity at G-protein coupled receptors: Advancing cannabinoid receptors as drug targets. Biochemical Pharmacology. PMID 27890725 DOI: 10.1016/j.bcp.2016.11.014  0.36
2016 Hua T, Vemuri K, Pu M, Qu L, Han GW, Wu Y, Zhao S, Shui W, Li S, Korde A, Laprairie RB, Stahl EL, Ho JH, Zvonok N, Zhou H, ... ... Makriyannis A, et al. Crystal Structure of the Human Cannabinoid Receptor CB1. Cell. 167: 750-762.e14. PMID 27768894 DOI: 10.1016/j.cell.2016.10.004  0.44
2016 Jacobs DS, Kohut SJ, Jiang S, Nikas SP, Makriyannis A, Bergman J. Acute and chronic effects of cannabidiol on Δ⁹-tetrahydrocannabinol (Δ⁹-THC)-induced disruption in stop signal task performance. Experimental and Clinical Psychopharmacology. 24: 320-330. PMID 27690502 DOI: 10.1037/pha0000081  0.44
2016 Kulkarni S, Nikas SP, Sharma R, Jiang S, Paronis CA, Leonard MZ, Zhang B, Honrao C, Mallipeddi S, Raghav JG, Benchama O, Järbe TU, Bergman J, Makriyannis A. Novel C-Ring-Hydroxy-substituted Controlled Deactivation Cannabinergic Analogues. Journal of Medicinal Chemistry. PMID 27367336 DOI: 10.1021/acs.jmedchem.6b00717  0.44
2016 Chopda GR, Parge VA, Thakur G, Gatley SJ, Makriyannis A, Paronis CA. Tolerance to the diuretic effects of cannabinoids and cross-tolerance to a kappa-opioid agonist in THC-treated mice. The Journal of Pharmacology and Experimental Therapeutics. PMID 27231154 DOI: 10.1124/jpet.116.232132  0.48
2016 Thompson EE, Jagielo-Miller JE, Vemuri VK, Makriyannis A, McLaughlin PJ. CB1 antagonism produces behaviors more consistent with satiety than reduced reward value in food-maintained responding in rats. Journal of Psychopharmacology (Oxford, England). PMID 27005309 DOI: 10.1177/0269881116639287  0.36
2016 Kangas BD, Leonard MZ, Shukla VG, Alapafuja SO, Nikas SP, Makriyannis A, Bergman J. Comparisons of Δ9-tetrahydrocannabinol and Anandamide on a Battery of Cognition-related Behavior in Nonhuman Primates. The Journal of Pharmacology and Experimental Therapeutics. PMID 26826191 DOI: 10.1124/jpet.115.228189  0.44
2016 Schindler CW, Scherma M, Redhi GH, Vadivel SK, Makriyannis A, Goldberg SR, Justinova Z. Self-administration of the anandamide transport inhibitor AM404 by squirrel monkeys. Psychopharmacology. PMID 26803499 DOI: 10.1007/s00213-016-4211-3  0.36
2016 Tyukhtenko S, Karageorgos I, Rajarshi G, Zvonok N, Pavlopoulos S, Janero DR, Makriyannis A. Specific Inter-residue Interactions as Determinants of Human Monoacylglycerol Lipase Catalytic Competency: A ROLE FOR GLOBAL CONFORMATIONAL CHANGES. The Journal of Biological Chemistry. 291: 2556-65. PMID 26555264 DOI: 10.1074/jbc.M115.670257  1
2015 Guo JJ, Yang DP, Tian X, Kiran Vemuri V, Yin D, Li C, Duclos RI, Shen L, Ma X, Janero DR, Makriyannis A. 17β-estradiol (E2) in membranes: Orientation and dynamic properties. Biochimica Et Biophysica Acta. PMID 26607010 DOI: 10.1016/j.bbamem.2015.11.015  1
2015 Panlilio LV, Thorndike EB, Nikas SP, Alapafuja SO, Bandiera T, Cravatt BF, Makriyannis A, Piomelli D, Goldberg SR, Justinova Z. Effects of fatty acid amide hydrolase (FAAH) inhibitors on working memory in rats. Psychopharmacology. PMID 26558620 DOI: 10.1007/s00213-015-4140-6  0.44
2015 Kulkarni PM, Kulkarni AR, Korde A, Tichkule RB, Laprairie RB, Denovan-Wright EM, Zhou H, Janero DR, Zvonok N, Makriyannis A, Cascio MG, Pertwee RG, Thakur GA. Novel Electrophilic and Photoaffinity Covalent Probes for Mapping the Cannabinoid 1 Receptor Allosteric Site(s). Journal of Medicinal Chemistry. PMID 26529344 DOI: 10.1021/acs.jmedchem.5b01303  0.44
2015 Janero DR, Yaddanapudi S, Zvonok N, Subramanian KV, Shukla VG, Stahl E, Zhou L, Hurst D, Wager-Miller J, Bohn LM, Reggio PH, Mackie K, Makriyannis A. Molecular-Interaction and Signaling Profiles of AM3677, a Novel Covalent Agonist Selective for the Cannabinoid 1 Receptor. Acs Chemical Neuroscience. PMID 25978068 DOI: 10.1021/acschemneuro.5b00090  1
2015 Shelnut EL, Nikas SP, Finnegan DF, Chiang N, Serhan CN, Makriyannis A. Design and synthesis of novel prostaglandin E2 ethanolamide and glycerol ester probes for the putative prostamide receptor(s). Tetrahedron Letters. 56: 1411-1415. PMID 25960577 DOI: 10.1016/j.tetlet.2015.01.164  1
2015 Ramsden CE, Zamora D, Makriyannis A, Wood JT, Mann JD, Faurot KR, MacIntosh BA, Majchrzak-Hong SF, Gross JR, Courville AB, Davis JM, Hibbeln JR. Diet-Induced Changes in n-3- and n-6-Derived Endocannabinoids and Reductions in Headache Pain and Psychological Distress. The Journal of Pain : Official Journal of the American Pain Society. PMID 25958314 DOI: 10.1016/j.jpain.2015.04.007  1
2015 Gamaleddin IH, Trigo JM, Gueye AB, Zvonok A, Makriyannis A, Goldberg SR, Le Foll B. Role of the endogenous cannabinoid system in nicotine addiction: novel insights. Frontiers in Psychiatry. 6: 41. PMID 25859226 DOI: 10.3389/fpsyt.2015.00041  1
2015 Tai S, Nikas SP, Shukla VG, Vemuri K, Makriyannis A, Järbe TU. Cannabinoid withdrawal in mice: inverse agonist vs neutral antagonist. Psychopharmacology. 232: 2751-61. PMID 25772338 DOI: 10.1007/s00213-015-3907-0  1
2015 Ogawa G, Tius MA, Zhou H, Nikas SP, Halikhedkar A, Mallipeddi S, Makriyannis A. 3'-functionalized adamantyl cannabinoid receptor probes. Journal of Medicinal Chemistry. 58: 3104-16. PMID 25760146 DOI: 10.1021/jm501960u  0.44
2015 Finnegan DF, Shelnut EL, Nikas SP, Chiang N, Serhan CN, Makriyannis A. Novel tail and head group prostamide probes. Bioorganic & Medicinal Chemistry Letters. 25: 1228-31. PMID 25701254 DOI: 10.1016/j.bmcl.2015.01.064  1
2015 Kudalkar SN, Nikas SP, Kingsley PJ, Xu S, Galligan JJ, Rouzer CA, Banerjee S, Ji L, Eno MR, Makriyannis A, Marnett LJ. 13-Methylarachidonic acid is a positive allosteric modulator of endocannabinoid oxygenation by cyclooxygenase. The Journal of Biological Chemistry. 290: 7897-909. PMID 25648895 DOI: 10.1074/jbc.M114.634014  0.44
2015 Bowles NP, Karatsoreos IN, Li X, Vemuri VK, Wood JA, Li Z, Tamashiro KL, Schwartz GJ, Makriyannis AM, Kunos G, Hillard CJ, McEwen BS, Hill MN. A peripheral endocannabinoid mechanism contributes to glucocorticoid-mediated metabolic syndrome. Proceedings of the National Academy of Sciences of the United States of America. 112: 285-90. PMID 25535367 DOI: 10.1073/pnas.1421420112  0.36
2015 Nikas SP, Sharma R, Paronis CA, Kulkarni S, Thakur GA, Hurst D, Wood JT, Gifford RS, Rajarshi G, Liu Y, Raghav JG, Guo JJ, Järbe TU, Reggio PH, Bergman J, ... Makriyannis A, et al. Probing the carboxyester side chain in controlled deactivation (-)-δ(8)-tetrahydrocannabinols. Journal of Medicinal Chemistry. 58: 665-81. PMID 25470070 DOI: 10.1021/jm501165d  1
2015 Alhouayek M, Bottemanne P, Subramanian KV, Lambert DM, Makriyannis A, Cani PD, Muccioli GG. N-Acylethanolamine-hydrolyzing acid amidase inhibition increases colon N-palmitoylethanolamine levels and counteracts murine colitis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 29: 650-61. PMID 25384424 DOI: 10.1096/fj.14-255208  1
2015 Tyukhtenko S, Chan K, Jiang R, Zhou H, Mercier RW, Yang DP, Makriyannis A, Guo JJ. Hydrogen-bonded His93 as a sensitive probe for identifying inhibitors of the endocannabinoid transport protein FABP7. Chemical Biology & Drug Design. 85: 534-40. PMID 25255720 DOI: 10.1111/cbdd.12440  1
2015 Deng L, Guindon J, Cornett BL, Makriyannis A, Mackie K, Hohmann AG. Chronic cannabinoid receptor 2 activation reverses paclitaxel neuropathy without tolerance or cannabinoid receptor 1-dependent withdrawal. Biological Psychiatry. 77: 475-87. PMID 24853387 DOI: 10.1016/j.biopsych.2014.04.009  1
2014 Fichna J, Bawa M, Thakur GA, Tichkule R, Makriyannis A, McCafferty DM, Sharkey KA, Storr M. Cannabinoids alleviate experimentally induced intestinal inflammation by acting at central and peripheral receptors. Plos One. 9: e109115. PMID 25275313 DOI: 10.1371/journal.pone.0109115  1
2014 Ntountaniotis D, Kellici T, Tzakos A, Kolokotroni P, Tselios T, Becker-Baldus J, Glaubitz C, Lin S, Makriyannis A, Mavromoustakos T. The application of solid-state NMR spectroscopy to study candesartan cilexetil (TCV-116) membrane interactions. Comparative study with the AT1R antagonist drug olmesartan. Biochimica Et Biophysica Acta. 1838: 2439-50. PMID 24946142 DOI: 10.1016/j.bbamem.2014.06.003  0.48
2014 Sharma R, Nikas SP, Guo JJ, Mallipeddi S, Wood JT, Makriyannis A. C-ring cannabinoid lactones: a novel cannabinergic chemotype. Acs Medicinal Chemistry Letters. 5: 400-4. PMID 24900848 DOI: 10.1021/ml4005304  1
2014 Rahn EJ, Deng L, Thakur GA, Vemuri K, Zvonok AM, Lai YY, Makriyannis A, Hohmann AG. Prophylactic cannabinoid administration blocks the development of paclitaxel-induced neuropathic nociception during analgesic treatment and following cessation of drug delivery. Molecular Pain. 10: 27. PMID 24742127 DOI: 10.1186/1744-8069-10-27  1
2014 Nader J, Rapino C, Gennequin B, Chavant F, Francheteau M, Makriyannis A, Duranti A, Maccarrone M, Solinas M, Thiriet N. Prior stimulation of the endocannabinoid system prevents methamphetamine-induced dopaminergic neurotoxicity in the striatum through activation of CB2 receptors. Neuropharmacology. 87: 214-21. PMID 24709540 DOI: 10.1016/j.neuropharm.2014.03.014  1
2014 Järbe TU, LeMay BJ, Halikhedkar A, Wood J, Vadivel SK, Zvonok A, Makriyannis A. Differentiation between low- and high-efficacy CB1 receptor agonists using a drug discrimination protocol for rats. Psychopharmacology. 231: 489-500. PMID 24005529 DOI: 10.1007/s00213-013-3257-8  0.36
2013 Guo JJ, Williams MK, Makriyannis A. Therapeutic Opportunities through the Modulation of Endocannabinoid Transport. Pharmaceutical Regulatory Affairs : Open Access. 3. PMID 25485182 DOI: 10.4172/2167-7689.1000e123  0.68
2013 Zhuang J, Yang DP, Tian X, Nikas SP, Sharma R, Guo JJ, Makriyannis A. Targeting the Endocannabinoid System for Neuroprotection: A (19)F-NMR Study of a Selective FAAH Inhibitor Binding with an Anandamide Carrier Protein, HSA. Journal of Pharmaceutics & Pharmacology. 1. PMID 24533425  0.68
2013 Fichna J, Wood JT, Papanastasiou M, Vadivel SK, Oprocha P, SaÅ‚aga M, Sobczak M, Mokrowiecka A, Cygankiewicz AI, Zakrzewski PK, MaÅ‚ecka-Panas E, Krajewska WM, KoÅ›cielniak P, Makriyannis A, Storr MA. Endocannabinoid and cannabinoid-like fatty acid amide levels correlate with pain-related symptoms in patients with IBS-D and IBS-C: a pilot study. Plos One. 8: e85073. PMID 24386448 DOI: 10.1371/journal.pone.0085073  1
2013 Sharma R, Nikas SP, Paronis CA, Wood JT, Halikhedkar A, Guo JJ, Thakur GA, Kulkarni S, Benchama O, Raghav JG, Gifford RS, Järbe TU, Bergman J, Makriyannis A. Controlled-deactivation cannabinergic ligands. Journal of Medicinal Chemistry. 56: 10142-57. PMID 24286207 DOI: 10.1021/jm4016075  1
2013 Chopda GR, Vemuri VK, Sharma R, Thakur GA, Makriyannis A, Paronis CA. Diuretic effects of cannabinoid agonists in mice. European Journal of Pharmacology. 721: 64-9. PMID 24099963 DOI: 10.1016/j.ejphar.2013.09.053  1
2013 Miller RL, Thakur GA, Stewart WN, Bow JP, Bajaj S, Makriyannis A, McLaughlin PJ. Effects of a novel CB1 agonist on visual attention in male rats: role of strategy and expectancy in task accuracy. Experimental and Clinical Psychopharmacology. 21: 416-25. PMID 24099361 DOI: 10.1037/a0033668  1
2013 Karageorgos I, Wales TE, Janero DR, Zvonok N, Vemuri VK, Engen JR, Makriyannis A. Active-site inhibitors modulate the dynamic properties of human monoacylglycerol lipase: a hydrogen exchange mass spectrometry study. Biochemistry. 52: 5016-26. PMID 23795559 DOI: 10.1021/bi400430k  1
2013 Thakur GA, Bajaj S, Paronis C, Peng Y, Bowman AL, Barak LS, Caron MG, Parrish D, Deschamps JR, Makriyannis A. Novel adamantyl cannabinoids as CB1 receptor probes. Journal of Medicinal Chemistry. 56: 3904-21. PMID 23621789 DOI: 10.1021/jm4000775  1
2013 McLaughlin PJ, Thakur GA, Vemuri VK, McClure ED, Brown CM, Winston KM, Wood JT, Makriyannis A, Salamone JD. Behavioral effects of the novel potent cannabinoid CB1 agonist AM 4054. Pharmacology, Biochemistry, and Behavior. 109: 16-22. PMID 23603029 DOI: 10.1016/j.pbb.2013.04.011  1
2013 Nasr ML, Shi X, Bowman AL, Johnson M, Zvonok N, Janero DR, Vemuri VK, Wales TE, Engen JR, Makriyannis A. Membrane phospholipid bilayer as a determinant of monoacylglycerol lipase kinetic profile and conformational repertoire. Protein Science : a Publication of the Protein Society. 22: 774-87. PMID 23553709 DOI: 10.1002/pro.2257  1
2013 Gamaleddin I, Guranda M, Scherma M, Fratta W, Makriyannis A, Vadivel SK, Goldberg SR, Le Foll B. AM404 attenuates reinstatement of nicotine seeking induced by nicotine-associated cues and nicotine priming but does not affect nicotine- and food-taking. Journal of Psychopharmacology (Oxford, England). 27: 564-71. PMID 23427192 DOI: 10.1177/0269881113477710  1
2013 Marcu J, Shore DM, Kapur A, Trznadel M, Makriyannis A, Reggio PH, Abood ME. Novel insights into CB1 cannabinoid receptor signaling: a key interaction identified between the extracellular-3 loop and transmembrane helix 2. The Journal of Pharmacology and Experimental Therapeutics. 345: 189-97. PMID 23426954 DOI: 10.1124/jpet.112.201046  1
2013 Zhuang J, Yang DP, Nikas SP, Zhao J, Guo J, Makriyannis A. The interaction of fatty acid amide hydrolase (FAAH) inhibitors with an anandamide carrier protein using (19)F-NMR. The Aaps Journal. 15: 477-82. PMID 23344792 DOI: 10.1208/s12248-013-9455-9  0.68
2013 Kangas BD, Delatte MS, Vemuri VK, Thakur GA, Nikas SP, Subramanian KV, Shukla VG, Makriyannis A, Bergman J. Cannabinoid discrimination and antagonism by CB(1) neutral and inverse agonist antagonists. The Journal of Pharmacology and Experimental Therapeutics. 344: 561-7. PMID 23287700 DOI: 10.1124/jpet.112.201962  1
2013 Desai RI, Thakur GA, Vemuri VK, Bajaj S, Makriyannis A, Bergman J. Analysis of tolerance and behavioral/physical dependence during chronic CB1 agonist treatment: effects of CB1 agonists, antagonists, and noncannabinoid drugs. The Journal of Pharmacology and Experimental Therapeutics. 344: 319-28. PMID 23197773 DOI: 10.1124/jpet.112.198374  1
2013 Bowman AL, Makriyannis A. Highly predictive ligand-based pharmacophore and homology models of ABHD6. Chemical Biology & Drug Design. 81: 382-8. PMID 23110439 DOI: 10.1111/cbdd.12086  0.36
2013 Paronis CA, Thakur GA, Bajaj S, Nikas SP, Vemuri VK, Makriyannis A, Bergman J. Diuretic effects of cannabinoids. The Journal of Pharmacology and Experimental Therapeutics. 344: 8-14. PMID 23019138 DOI: 10.1124/jpet.112.199331  1
2013 Wood JT, Smith DM, Janero DR, Zvonok AM, Makriyannis A. Therapeutic modulation of cannabinoid lipid signaling: metabolic profiling of a novel antinociceptive cannabinoid-2 receptor agonist. Life Sciences. 92: 482-91. PMID 22749867 DOI: 10.1016/j.lfs.2012.06.019  1
2012 Nikas SP, D'Souza M, Makriyannis A. Enantioselective synthesis of (10S)- and (10R)-methyl-anandamides. Tetrahedron. 68. PMID 24319298 DOI: 10.1016/j.tet.2012.05.010  0.44
2012 Lu D, Nikas SP, Han XW, Parrish DA, Makriyannis A. Synthesis and characterization of a compact tricyclic resorcinol from (+)- and (-)-3-pinanol. Tetrahedron Letters. 53: 4636-4638. PMID 24052669 DOI: 10.1016/j.tetlet.2012.05.165  1
2012 Whitten KM, Makriyannis A, Vadivel SK. Enzymatic synthesis of N-Acylethanolamines: Direct method for the aminolysis of esters. Tetrahedron Letters. 53: 5753-5755. PMID 23175586 DOI: 10.1016/j.tetlet.2012.08.042  0.36
2012 Alapafuja SO, Nikas SP, Bharathan IT, Shukla VG, Nasr ML, Bowman AL, Zvonok N, Li J, Shi X, Engen JR, Makriyannis A. Sulfonyl fluoride inhibitors of fatty acid amide hydrolase. Journal of Medicinal Chemistry. 55: 10074-89. PMID 23083016 DOI: 10.1021/jm301205j  1
2012 Paronis CA, Nikas SP, Shukla VG, Makriyannis A. Δ(9)-Tetrahydrocannabinol acts as a partial agonist/antagonist in mice. Behavioural Pharmacology. 23: 802-5. PMID 23075707 DOI: 10.1097/FBP.0b013e32835a7c4d  1
2012 Deng L, Guindon J, Vemuri VK, Thakur GA, White FA, Makriyannis A, Hohmann AG. The maintenance of cisplatin- and paclitaxel-induced mechanical and cold allodynia is suppressed by cannabinoid CBâ‚‚ receptor activation and independent of CXCR4 signaling in models of chemotherapy-induced peripheral neuropathy. Molecular Pain. 8: 71. PMID 22998838 DOI: 10.1186/1744-8069-8-71  1
2012 West JM, Zvonok N, Whitten KM, Vadivel SK, Bowman AL, Makriyannis A. Biochemical and mass spectrometric characterization of human N-acylethanolamine-hydrolyzing acid amidase inhibition. Plos One. 7: e43877. PMID 22952796 DOI: 10.1371/journal.pone.0043877  1
2012 Karageorgos I, Zvonok N, Janero DR, Vemuri VK, Shukla V, Wales TE, Engen JR, Makriyannis A. Endocannabinoid enzyme engineering: soluble human thio-monoacylglycerol lipase (sol-S-hMGL). Acs Chemical Neuroscience. 3: 393-9. PMID 22860208 DOI: 10.1021/cn3000263  1
2012 Whitten KM, Makriyannis A, Vadivel SK. Application of Chemoenzymatic Hydrolysis in the Synthesis of 2-Monoacylglycerols. Tetrahedron. 68: 5422-5428. PMID 22822273 DOI: 10.1016/j.tet.2012.04.101  0.36
2012 Dixon DD, Tius MA, Thakur GA, Zhou H, Bowman AL, Shukla VG, Peng Y, Makriyannis A. C3-heteroaroyl cannabinoids as photolabeling ligands for the CB2 cannabinoid receptor. Bioorganic & Medicinal Chemistry Letters. 22: 5322-5. PMID 22796181 DOI: 10.1016/j.bmcl.2012.06.013  1
2012 Johnston M, Bhatt SR, Sikka S, Mercier RW, West JM, Makriyannis A, Gatley SJ, Duclos RI. Assay and inhibition of diacylglycerol lipase activity Bioorganic and Medicinal Chemistry Letters. 22: 4585-4592. PMID 22738638 DOI: 10.1016/j.bmcl.2012.05.101  1
2012 Shen L, Huang H, Makriyannis A, Fisher LS. Integrated ligand based pharmacophore model derived from diverse FAAH covalent ligand classes. Current Computer-Aided Drug Design. 8: 330-4. PMID 22734710 DOI: 10.2174/157340912803519615  1
2012 Wilkerson JL, Gentry KR, Dengler EC, Wallace JA, Kerwin AA, Kuhn MN, Zvonok AM, Thakur GA, Makriyannis A, Milligan ED. Immunofluorescent spectral analysis reveals the intrathecal cannabinoid agonist, AM1241, produces spinal anti-inflammatory cytokine responses in neuropathic rats exhibiting relief from allodynia. Brain and Behavior. 2: 155-77. PMID 22574283 DOI: 10.1002/brb3.44  1
2012 Wilkerson JL, Gentry KR, Dengler EC, Wallace JA, Kerwin AA, Armijo LM, Kuhn MN, Thakur GA, Makriyannis A, Milligan ED. Intrathecal cannabilactone CB(2)R agonist, AM1710, controls pathological pain and restores basal cytokine levels. Pain. 153: 1091-106. PMID 22425445 DOI: 10.1016/j.pain.2012.02.015  1
2012 Gamaleddin I, Zvonok A, Makriyannis A, Goldberg SR, Le Foll B. Effects of a selective cannabinoid CB2 agonist and antagonist on intravenous nicotine self administration and reinstatement of nicotine seeking. Plos One. 7: e29900. PMID 22291896 DOI: 10.1371/journal.pone.0029900  1
2012 Naidoo V, Karanian DA, Vadivel SK, Locklear JR, Wood JT, Nasr M, Quizon PM, Graves EE, Shukla V, Makriyannis A, Bahr BA. Equipotent inhibition of fatty acid amide hydrolase and monoacylglycerol lipase - dual targets of the endocannabinoid system to protect against seizure pathology. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 9: 801-13. PMID 22270809 DOI: 10.1007/s13311-011-0100-y  1
2012 West JM, Zvonok N, Whitten KM, Wood JT, Makriyannis A. Mass spectrometric characterization of human N -acylethanolamine- hydrolyzing acid amidase Journal of Proteome Research. 11: 972-981. PMID 22040171 DOI: 10.1021/pr200735a  1
2012 Järbe TU, Tai S, LeMay BJ, Nikas SP, Shukla VG, Zvonok A, Makriyannis A. AM2389, a high-affinity, in vivo potent CB1-receptor-selective cannabinergic ligand as evidenced by drug discrimination in rats and hypothermia testing in mice. Psychopharmacology. 220: 417-26. PMID 21989802 DOI: 10.1007/s00213-011-2491-1  1
2012 Scherma M, Justinová Z, Zanettini C, Panlilio LV, Mascia P, Fadda P, Fratta W, Makriyannis A, Vadivel SK, Gamaleddin I, Le Foll B, Goldberg SR. The anandamide transport inhibitor AM404 reduces the rewarding effects of nicotine and nicotine-induced dopamine elevations in the nucleus accumbens shell in rats. British Journal of Pharmacology. 165: 2539-48. PMID 21557729 DOI: 10.1111/j.1476-5381.2011.01467.x  1
2011 Janero DR, Lindsley L, Vemuri VK, Makriyannis A. Cannabinoid 1 G protein-coupled receptor (periphero-)neutral antagonists: emerging therapeutics for treating obesity-driven metabolic disease and reducing cardiovascular risk. Expert Opinion On Drug Discovery. 6: 995-1025. PMID 22646861 DOI: 10.1517/17460441.2011.608063  0.36
2011 Bowman AL, Makriyannis A. Approximating protein flexibility through dynamic pharmacophore models: application to fatty acid amide hydrolase (FAAH). Journal of Chemical Information and Modeling. 51: 3247-53. PMID 22098169 DOI: 10.1021/ci200371z  0.36
2011 Makriyannis A, Nikas SP. Aspirin-triggered metabolites of EFAs. Chemistry & Biology. 18: 1208-9. PMID 22035788 DOI: 10.1016/j.chembiol.2011.10.005  0.44
2011 Teng H, Thakur GA, Makriyannis A. Conformationally constrained analogs of BAY 59-3074 as novel cannabinoid receptor ligands. Bioorganic & Medicinal Chemistry Letters. 21: 5999-6002. PMID 21880487 DOI: 10.1016/j.bmcl.2011.07.017  1
2011 Szymanski DW, Papanastasiou M, Melchior K, Zvonok N, Mercier RW, Janero DR, Thakur GA, Cha S, Wu B, Karger B, Makriyannis A. Mass spectrometry-based proteomics of human cannabinoid receptor 2: Covalent cysteine 6.47(257)-ligand interaction affording megagonist receptor activation Journal of Proteome Research. 10: 4789-4798. PMID 21861534 DOI: 10.1021/pr2005583  1
2011 Järbe TU, Deng H, Vadivel SK, Makriyannis A. Cannabinergic aminoalkylindoles, including AM678=JWH018 found in 'Spice', examined using drug (Δ(9)-tetrahydrocannabinol) discrimination for rats. Behavioural Pharmacology. 22: 498-507. PMID 21836461 DOI: 10.1097/FBP.0b013e328349fbd5  0.48
2011 Gutierrez T, Crystal JD, Zvonok AM, Makriyannis A, Hohmann AG. Self-medication of a cannabinoid CB2 agonist in an animal model of neuropathic pain. Pain. 152: 1976-87. PMID 21550725 DOI: 10.1016/j.pain.2011.03.038  1
2011 Rahn EJ, Thakur GA, Wood JA, Zvonok AM, Makriyannis A, Hohmann AG. Pharmacological characterization of AM1710, a putative cannabinoid CB2 agonist from the cannabilactone class: antinociception without central nervous system side-effects. Pharmacology, Biochemistry, and Behavior. 98: 493-502. PMID 21382397 DOI: 10.1016/j.pbb.2011.02.024  1
2011 Duclos RI, Johnston M, Vadivel SK, Makriyannis A, Glaser ST, Gatley SJ. A methodology for radiolabeling of the endocannabinoid 2-arachidonoylglycerol (2-AG). The Journal of Organic Chemistry. 76: 2049-55. PMID 21370840 DOI: 10.1021/jo102277q  1
2011 Järbe TU, LeMay BJ, Vemuri VK, Vadivel SK, Zvonok A, Makriyannis A. Central mediation and differential blockade by cannabinergics of the discriminative stimulus effects of the cannabinoid CB1 receptor antagonist rimonabant in rats. Psychopharmacology. 216: 355-65. PMID 21369753 DOI: 10.1007/s00213-011-2226-3  0.36
2011 Singh SN, Bakshi K, Mercier RW, Makriyannis A, Pavlopoulos S. Binding between a distal C-terminus fragment of cannabinoid receptor 1 and arrestin-2. Biochemistry. 50: 2223-34. PMID 21306178 DOI: 10.1021/bi1018144  1
2011 Tiburu EK, Tyukhtenko S, Zhou H, Janero DR, Struppe J, Makriyannis A. Human cannabinoid 1 GPCR C-terminal domain interacts with bilayer phospholipids to modulate the structure of its membrane environment. The Aaps Journal. 13: 92-8. PMID 21234731 DOI: 10.1208/s12248-010-9244-7  0.44
2011 Tian X, Pavlopoulos S, Yang DP, Makriyannis A. The interaction of cannabinoid receptor agonists, CP55940 and WIN55212-2 with membranes using solid state 2H NMR. Biochimica Et Biophysica Acta. 1808: 2095-101. PMID 21129361 DOI: 10.1016/j.bbamem.2010.11.026  1
2011 Naidoo V, Nikas SP, Karanian DA, Hwang J, Zhao J, Wood JT, Alapafuja SO, Vadivel SK, Butler D, Makriyannis A, Bahr BA. A new generation fatty acid amide hydrolase inhibitor protects against kainate-induced excitotoxicity. Journal of Molecular Neuroscience : Mn. 43: 493-502. PMID 21069475 DOI: 10.1007/s12031-010-9472-4  1
2011 Cluny NL, Chambers AP, Vemuri VK, Wood JT, Eller LK, Freni C, Reimer RA, Makriyannis A, Sharkey KA. The neutral cannabinoid CB₁ receptor antagonist AM4113 regulates body weight through changes in energy intake in the rat. Pharmacology, Biochemistry, and Behavior. 97: 537-43. PMID 21056053 DOI: 10.1016/j.pbb.2010.10.013  1
2010 Guo J, Duclos RI, Vemuri VK, Makriyannis A. The Conformations of 17β-Estradiol (E2) and 17α-Estradiol as Determined by Solution NMR. Tetrahedron Letters. 51: 3465-3469. PMID 21442021 DOI: 10.1016/j.tetlet.2010.04.077  0.68
2010 Godlewski G, Alapafuja SO, Bátkai S, Nikas SP, Cinar R, Offertáler L, Osei-Hyiaman D, Liu J, Mukhopadhyay B, Harvey-White J, Tam J, Pacak K, Blankman JL, Cravatt BF, Makriyannis A, et al. Inhibitor of fatty acid amide hydrolase normalizes cardiovascular function in hypertension without adverse metabolic effects. Chemistry & Biology. 17: 1256-66. PMID 21095576 DOI: 10.1016/j.chembiol.2010.08.013  1
2010 Mercier RW, Pei Y, Pandarinathan L, Janero DR, Zhang J, Makriyannis A. hCB2 ligand-interaction landscape: cysteine residues critical to biarylpyrazole antagonist binding motif and receptor modulation. Chemistry & Biology. 17: 1132-42. PMID 21035736 DOI: 10.1016/j.chembiol.2010.08.010  1
2010 Nikas SP, Alapafuja SO, Papanastasiou I, Paronis CA, Shukla VG, Papahatjis DP, Bowman AL, Halikhedkar A, Han X, Makriyannis A. Novel 1',1'-chain substituted hexahydrocannabinols: 9β-hydroxy-3-(1-hexyl-cyclobut-1-yl)-hexahydrocannabinol (AM2389) a highly potent cannabinoid receptor 1 (CB1) agonist. Journal of Medicinal Chemistry. 53: 6996-7010. PMID 20925434 DOI: 10.1021/jm100641g  1
2010 Järbe TU, Gifford RS, Makriyannis A. Antagonism of ∆⁹-THC induced behavioral effects by rimonabant: time course studies in rats. European Journal of Pharmacology. 648: 133-8. PMID 20854804 DOI: 10.1016/j.ejphar.2010.09.006  1
2010 Selvakumar J, Makriyannis A, Ramanathan CR. An unusual reactivity of BBr(3): Accessing tetrahydroisoquinoline units from N-phenethylimides. Organic & Biomolecular Chemistry. 8: 4056-8. PMID 20664860 DOI: 10.1039/c0ob00269k  1
2010 Tam J, Vemuri VK, Liu J, Bátkai S, Mukhopadhyay B, Godlewski G, Osei-Hyiaman D, Ohnuma S, Ambudkar SV, Pickel J, Makriyannis A, Kunos G. Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity. The Journal of Clinical Investigation. 120: 2953-66. PMID 20664173 DOI: 10.1172/JCI42551  1
2010 Dixon DD, Sethumadhavan D, Benneche T, Banaag AR, Tius MA, Thakur GA, Bowman A, Wood JT, Makriyannis A. Heteroadamantyl cannabinoids. Journal of Medicinal Chemistry. 53: 5656-66. PMID 20593789 DOI: 10.1021/jm100390h  1
2010 Karageorgos I, Tyukhtenko S, Zvonok N, Janero DR, Sallum C, Makriyannis A. Identification by nuclear magnetic resonance spectroscopy of an active-site hydrogen-bond network in human monoacylglycerol lipase (hMGL): implications for hMGL dynamics, pharmacological inhibition, and catalytic mechanism. Molecular Biosystems. 6: 1381-8. PMID 20464001 DOI: 10.1039/c004515b  0.44
2010 Papahatjis DP, Nahmias VR, Nikas SP, Schimpgen M, Makriyannis A. Design and synthesis of (13S)-methyl-substituted arachidonic acid analogues: templates for novel endocannabinoids. Chemistry (Weinheim An Der Bergstrasse, Germany). 16: 4091-9. PMID 20187040 DOI: 10.1002/chem.200902880  0.72
2010 Rahn EJ, Zvonok AM, Makriyannis A, Hohmann AG. Antinociceptive effects of racemic AM1241 and its chirally synthesized enantiomers: lack of dependence upon opioid receptor activation. The Aaps Journal. 12: 147-57. PMID 20127295 DOI: 10.1208/s12248-009-9170-8  1
2010 Wood JT, Williams JS, Pandarinathan L, Janero DR, Lammi-Keefe CJ, Makriyannis A. Dietary docosahexaenoic acid supplementation alters select physiological endocannabinoid-system metabolites in brain and plasma Journal of Lipid Research. 51: 1416-1423. PMID 20071693 DOI: 10.1194/jlr.M002436  1
2010 Järbe TU, Li C, Vadivel SK, Makriyannis A. Discriminative stimulus functions of methanandamide and delta(9)-THC in rats: tests with aminoalkylindoles (WIN55,212-2 and AM678) and ethanol. Psychopharmacology. 208: 87-98. PMID 19902182 DOI: 10.1007/s00213-009-1708-z  0.36
2010 Hwang J, Adamson C, Butler D, Janero DR, Makriyannis A, Bahr BA. Enhancement of endocannabinoid signaling by fatty acid amide hydrolase inhibition: a neuroprotective therapeutic modality. Life Sciences. 86: 615-23. PMID 19527737 DOI: 10.1016/j.lfs.2009.06.003  1
2009 Sharma R, Vadivel SK, Duclos RI, Makriyannis A. Open vessel mode microwave-assisted synthesis of 2-oxazolines from carboxylic acids. Tetrahedron Letters. 50: 5780-5782. PMID 21533007 DOI: 10.1016/j.tetlet.2009.07.079  0.56
2009 Alapafuja SO, Nikas SP, Shukla VG, Papanastasiou I, Makriyannis A. Microwave Assisted Synthesis of Sodium Sulfonates Precursors of Sulfonyl Chlorides and Fluorides. Tetrahedron Letters. 50: 7028-7031. PMID 21132105 DOI: 10.1016/j.tetlet.2009.09.167  1
2009 Thakur GA, Tichkule R, Bajaj S, Makriyannis A. Latest advances in cannabinoid receptor agonists. Expert Opinion On Therapeutic Patents. 19: 1647-73. PMID 19939187 DOI: 10.1517/13543770903436505  1
2009 Tyukhtenko S, Tiburu EK, Deshmukh L, Vinogradova O, Janero DR, Makriyannis A. NMR solution structure of human cannabinoid receptor-1 helix 7/8 peptide: candidate electrostatic interactions and microdomain formation. Biochemical and Biophysical Research Communications. 390: 441-6. PMID 19766594 DOI: 10.1016/j.bbrc.2009.09.053  0.44
2009 Bowman AL, Makriyannis A. Refined homology model of monoacylglycerol lipase: toward a selective inhibitor. Journal of Computer-Aided Molecular Design. 23: 799-806. PMID 19543978 DOI: 10.1007/s10822-009-9289-9  0.36
2008 Duclos RI, Lu D, Guo J, Makriyannis A. Synthesis and characterization of 2-substituted bornane pharmacophores for novel cannabinergic ligands. Tetrahedron Letters. 49: 5587-5589. PMID 23935221 DOI: 10.1016/j.tetlet.2008.07.029  0.68
2008 Guo J, Yang DP, Chari R, Tian X, Pavlopoulos S, Lu D, Makriyannis A. Magnetically aligned bicelles to study the orientation of lipophilic ligands in membrane bilayers. Journal of Medicinal Chemistry. 51: 6793-9. PMID 18834109 DOI: 10.1021/jm800766x  1
2008 Lu D, Guo J, Duclos RI, Bowman AL, Makriyannis A. Bornyl- and isobornyl-Delta8-tetrahydrocannabinols: a novel class of cannabinergic ligands. Journal of Medicinal Chemistry. 51: 6393-9. PMID 18826296 DOI: 10.1021/jm8005299  0.68
2007 Vadivel SK, Vardarajan S, Duclos RI, Wood JT, Guo J, Makriyannis A. Conformationally constrained analogues of 2-arachidonoylglycerol Bioorganic and Medicinal Chemistry Letters. 17: 5959-5963. PMID 17826996 DOI: 10.1016/j.bmcl.2007.07.064  1
2007 Papahatjis DP, Nahmias VR, Nikas SP, Andreou T, Alapafuja SO, Tsotinis A, Guo J, Fan P, Makriyannis A. C1'-cycloalkyl side chain pharmacophore in tetrahydrocannabinols. Journal of Medicinal Chemistry. 50: 4048-60. PMID 17672444 DOI: 10.1021/jm070121a  0.72
2007 Zvonok N, Yaddanapudi S, Williams J, Dai S, Dong K, Rejtar T, Karger BL, Makriyannis A. Comprehensive proteomic mass spectrometric characterization of human cannabinoid CB2 receptor. Journal of Proteome Research. 6: 2068-79. PMID 17472360 DOI: 10.1021/pr060671h  1
2006 Dhawan J, Deng H, Gatley SJ, Makriyannis A, Akinfeleye T, Bruneus M, Dimaio AA, Gifford AN. Evaluation of the in vivo receptor occupancy for the behavioral effects of cannabinoids using a radiolabeled cannabinoid receptor agonist, R-[125/131I]AM2233. Synapse (New York, N.Y.). 60: 93-101. PMID 16715483 DOI: 10.1002/syn.20277  0.48
2005 Deng H, Gifford AN, Zvonok AM, Cui G, Li X, Fan P, Deschamps JR, Flippen-Anderson JL, Gatley SJ, Makriyannis A. Potent cannabinergic indole analogues as radioiodinatable brain imaging agents for the CB1 cannabinoid receptor. Journal of Medicinal Chemistry. 48: 6386-92. PMID 16190764 DOI: 10.1021/jm050135l  0.48
2005 Makriyannis A, Tian X, Guo J. How lipophilic cannabinergic ligands reach their receptor sites. Prostaglandins & Other Lipid Mediators. 77: 210-8. PMID 16099405 DOI: 10.1016/j.prostaglandins.2004.01.010  0.68
2005 Xu W, Filppula SA, Mercier R, Yaddanapudi S, Pavlopoulos S, Cai J, Pierce WM, Makriyannis A. Purification and mass spectroscopic analysis of human CB1 cannabinoid receptor functionally expressed using the baculovirus system. The Journal of Peptide Research : Official Journal of the American Peptide Society. 66: 138-50. PMID 16083441 DOI: 10.1111/j.1399-3011.2005.00283.x  1
2005 Tian X, Guo J, Yao F, Yang DP, Makriyannis A. The conformation, location, and dynamic properties of the endocannabinoid ligand anandamide in a membrane bilayer. The Journal of Biological Chemistry. 280: 29788-95. PMID 15964843 DOI: 10.1074/jbc.M502925200  0.68
2005 Makriyannis A, Guo J, Tian X. Albumin enhances the diffusion of lipophilic drugs into the membrane bilayer. Life Sciences. 77: 1605-11. PMID 15964025 DOI: 10.1016/j.lfs.2005.05.008  0.68
2005 Choi G, Guo J, Makriyannis A. The conformation of the cytoplasmic helix 8 of the CB1 cannabinoid receptor using NMR and circular dichroism. Biochimica Et Biophysica Acta. 1668: 1-9. PMID 15670725 DOI: 10.1016/j.bbamem.2004.10.011  0.68
2004 Nikas SP, Grzybowska J, Papahatjis DP, Charalambous A, Banijamali AR, Chari R, Fan P, Kourouli T, Lin S, Nitowski AJ, Marciniak G, Guo Y, Li X, Wang CL, Makriyannis A. The role of halogen substitution in classical cannabinoids: a CB1 pharmacophore model. The Aaps Journal. 6: e30. PMID 15760095 DOI: 10.1208/aapsj060430  0.72
2004 Filppula S, Yaddanapudi S, Mercier R, Xu W, Pavlopoulos S, Makriyannis A. Purification and mass spectroscopic analysis of human CB2 cannabinoid receptor expressed in the baculovirus system. The Journal of Peptide Research : Official Journal of the American Peptide Society. 64: 225-36. PMID 15613086 DOI: 10.1111/j.1399-3011.2004.00188.x  1
2004 Fegley D, Kathuria S, Mercier R, Li C, Goutopoulos A, Makriyannis A, Piomelli D. Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172. Proceedings of the National Academy of Sciences of the United States of America. 101: 8756-61. PMID 15138300 DOI: 10.1073/pnas.0400997101  1
2003 Guo J, Pavlopoulos S, Tian X, Lu D, Nikas SP, Yang DP, Makriyannis A. Conformational study of lipophilic ligands in phospholipid model membrane systems by solution NMR. Journal of Medicinal Chemistry. 46: 4838-46. PMID 14584935 DOI: 10.1021/jm020385r  1
2003 Ibrahim MM, Deng H, Zvonok A, Cockayne DA, Kwan J, Mata HP, Vanderah TW, Lai J, Porreca F, Makriyannis A, Malan TP. Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS. Proceedings of the National Academy of Sciences of the United States of America. 100: 10529-33. PMID 12917492 DOI: 10.1073/pnas.1834309100  1
2003 Papahatjis DP, Nikas SP, Kourouli T, Chari R, Xu W, Pertwee RG, Makriyannis A. Pharmacophoric requirements for the cannabinoid side chain. Probing the cannabinoid receptor subsite at C1'. Journal of Medicinal Chemistry. 46: 3221-9. PMID 12852753 DOI: 10.1021/jm020558c  0.72
2002 Goutopoulos A, Makriyannis A. From cannabis to cannabinergics: new therapeutic opportunities. Pharmacology & Therapeutics. 95: 103-17. PMID 12182958 DOI: 10.1016/S0163-7258(02)00250-4  1
2001 Malan TP, Ibrahim MM, Deng H, Liu Q, Mata HP, Vanderah T, Porreca F, Makriyannis A. CB2 cannabinoid receptor-mediated peripheral antinociception. Pain. 93: 239-45. PMID 11514083 DOI: 10.1016/S0304-3959(01)00321-9  1
2001 Goutopoulos A, Fan P, Khanolkar AD, Xie XQ, Lin S, Makriyannis A. Stereochemical selectivity of methanandamides for the CB1 and CB2 cannabinoid receptors and their metabolic stability. Bioorganic & Medicinal Chemistry. 9: 1673-84. PMID 11425567 DOI: 10.1016/S0968-0896(01)00088-8  1
2000 Lamb RJ, Järbe TU, Makriyannis A, Lin S, Goutopoulos A. Effects of Delta 9-tetrahydrocannabinol, (R)-methanandamide, SR 141716,and d-amphetamine before and during daily Delta 9-tetrahydrocannabinol dosing. European Journal of Pharmacology. 398: 251-8. PMID 10854837 DOI: 10.1016/S0014-2999(00)00318-6  1
1999 Gifford AN, Bruneus M, Lin S, Goutopoulos A, Makriyannis A, Volkow ND, Gatley SJ. Potentiation of the action of anandamide on hippocampal slices by the fatty acid amide hydrolase inhibitor, palmitylsulphonyl fluoride (AM 374). European Journal of Pharmacology. 383: 9-14. PMID 10556675 DOI: 10.1016/S0014-2999(99)00609-3  1
1999 Piomelli D, Beltramo M, Glasnapp S, Lin SY, Goutopoulos A, Xie XQ, Makriyannis A. Structural determinants for recognition and translocation by the anandamide transporter. Proceedings of the National Academy of Sciences of the United States of America. 96: 5802-7. PMID 10318965 DOI: 10.1073/pnas.96.10.5802  1
1999 Lang W, Qin C, Lin S, Khanolkar AD, Goutopoulos A, Fan P, Abouzid K, Meng Z, Biegel D, Makriyannis A. Substrate Specificity and Stereoselectivity of Rat Brain Microsomal Anandamide Amidohydrolase. Journal of Medicinal Chemistry. 42: 1682. PMID 10231226 DOI: 10.1021/jm990139o  1
1999 Lang W, Qin C, Lin S, Khanolkar AD, Goutopoulos A, Fan P, Abouzid K, Meng Z, Biegel D, Makriyannis A. Substrate specificity and stereoselectivity of rat brain microsomal anandamide amidohydrolase. Journal of Medicinal Chemistry. 42: 896-902. PMID 10072686 DOI: 10.1021/jm980461j  1
1998 Järbe TU, Sheppard R, Lamb RJ, Makriyannis A, Lin S, Goutopoulos A. Effects of delta-9-tetrahydrocannabinol and (R)-methanandamide on open-field behavior in rats. Behavioural Pharmacology. 9: 169-74. PMID 10065936  1
1998 Järbe TU, Lamb RJ, Makriyannis A, Lin S, Goutopoulos A. Delta9-THC training dose as a determinant for (R)-methanandamide generalization in rats. Psychopharmacology. 140: 519-22. PMID 9888629 DOI: 10.1007/s002130050797  1
1998 Lin S, Khanolkar AD, Fan P, Goutopoulos A, Qin C, Papahadjis D, Makriyannis A. Novel analogues of arachidonylethanolamide (anandamide): affinities for the CB1 and CB2 cannabinoid receptors and metabolic stability. Journal of Medicinal Chemistry. 41: 5353-61. PMID 9876105 DOI: 10.1021/jm970257g  1
1998 Qin C, Lin S, Lang W, Goutopoulos A, Pavlopoulos S, Mauri F, Makriyannis A. Determination of anandamide amidase activity using ultraviolet-active amine derivatives and reverse-phase high-performance liquid chromatography. Analytical Biochemistry. 261: 8-15. PMID 9683506 DOI: 10.1006/abio.1998.2713  1
1998 Paria BC, Ma W, Andrenyak DM, Schmid PC, Schmid HH, Moody DE, Deng H, Makriyannis A, Dey SK. Effects of cannabinoids on preimplantation mouse embryo development and implantation are mediated by brain-type cannabinoid receptors. Biology of Reproduction. 58: 1490-5. PMID 9623610  0.48
1998 Papahatjis DP, Kourouli T, Abadji V, Goutopoulos A, Makriyannis A. Pharmacophoric requirements for cannabinoid side chains: multiple bond and C1'-substituted delta 8-tetrahydrocannabinols. Journal of Medicinal Chemistry. 41: 1195-200. PMID 9544219 DOI: 10.1021/jm970277i  1
1998 Landsman RS, Makriyannis A, Deng H, Consroe P, Roeske WR, Yamamura HI. AM630 is an inverse agonist at the human cannabinoid CB1 receptor. Life Sciences. 62: PL109-13. PMID 9496703 DOI: 10.1016/S0024-3205(97)01187-9  1
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